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  1. BMP9-stimulated DPSCs, SCAPs and PDLSCs are effective candidates for repairing maxillofacial bone defects in tissue engineering, while the most suitable seed cell source among these three hDMSCs and the optima...

    Authors: Yuxin Zhang, Wenping Luo, Liwen Zheng, Jing Hu, Li Nie, Huan Zeng, Xi Tan, Yucan Jiang, Yeming Li, Tianyu Zhao, Zhuohui Yang, Tong-Chuan He and Hongmei Zhang
    Citation: Stem Cell Research & Therapy 2022 13:535
    Content type: Research Published on:

  2. Rett syndrome (RTT), mainly caused by mutations in methyl-CpG binding protein 2 (MECP2), is one of the most prevalent neurodevelopmental disorders in girls. However, the underlying mechanism of MECP2 remains l...

    Authors: Ya-Jie Xu, Pei-Pei Liu, Zhong-Ze Yan, Ting-Wei Mi, Ying-Ying Wang, Qian Li, Zhao-Qian Teng and Chang-Mei Liu
    Citation: Stem Cell Research & Therapy 2022 13:534
    Content type: Research Published on:

  3. Bone marrow mesenchymal stromal cells (BMSCs) are promising for therapeutic use in cartilage repair, because of their capacity to differentiate into chondrocytes. Often, in vitro differentiation protocols empl...

    Authors: Daniele Zuncheddu, Elena Della Bella, Dalila Petta, Cecilia Bärtschi, Sonja Häckel, Moritz C. Deml, Martin J. Stoddart, Sibylle Grad and Valentina Basoli
    Citation: Stem Cell Research & Therapy 2022 13:533
    Content type: Research Published on:

  4. Sprouting angiogenesis is an important mechanism for morphogenetic phenomena, including organ development, wound healing, and tissue regeneration. In regenerative medicine, therapeutic angiogenesis is a clinic...

    Authors: Takanori Sano, Tadaaki Nakajima, Koharu Alicia Senda, Shizuka Nakano, Mizuho Yamato, Yukinori Ikeda, Hedele Zeng, Jun-ichi Kawabe and Yukiko T. Matsunaga
    Citation: Stem Cell Research & Therapy 2022 13:532
    Content type: Research Published on:

  5. Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPSC-CMs) do not display all hallmarks of mature primary cardiomyocytes, especially the ability to use fatty acids (FA) as an energy source, c...

    Authors: Nino Chirico, Elise L. Kessler, Renée G. C. Maas, Juntao Fang, Jiabin Qin, Inge Dokter, Mark Daniels, Tomo Šarić, Klaus Neef, Jan-Willem Buikema, Zhiyong Lei, Pieter A. Doevendans, Joost P. G. Sluijter and Alain van Mil
    Citation: Stem Cell Research & Therapy 2022 13:531
    Content type: Research Published on:

  6. Authors: Rongchuan Yue, Wenbin Fu, Xiang Liao, Cong Lan, Qiao Liao, Liangpeng Li, Dezhong Yang, Xuewei Xia, Xiongwen Chen, Chunyu Zeng and Wei Eric Wang
    Citation: Stem Cell Research & Therapy 2022 13:530
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2017 8:17

  7. Tissue organoids generated from human pluripotent stem cells are valuable tools for disease modelling and to understand developmental processes. While recent progress in human cardiac organoids revealed the ab...

    Authors: Beatrice Xuan Ho, Jeremy Kah Sheng Pang, Ying Chen, Yuin-Han Loh, Omer An, Henry He Yang, Veerabrahma Pratap Seshachalam, Judice L. Y. Koh, Woon-Khiong Chan, Shi Yan Ng and Boon Seng Soh
    Citation: Stem Cell Research & Therapy 2022 13:529
    Content type: Research Published on:

  8. Nowadays, diabetes mellitus is known as a silent killer because individual is not aware that he has the disease till the development of its complications. Many researchers have studied the use of stem cells in...

    Authors: Alyaa Farid, Hebatallah Haridyy, Salma Ashraf, Selim Ahmed and Gehan Safwat
    Citation: Stem Cell Research & Therapy 2022 13:528
    Content type: Research Published on:

  9. Brain tumors are one of the most mortal cancers, leading to many deaths among kids and adults. Surgery, chemotherapy, and radiotherapy are available options for brain tumor treatment. However, these methods ar...

    Authors: Elham Ghasempour, Shilan Hesami, Elaheh Movahed, Saeed Heidari keshel and Mohammad Doroudian
    Citation: Stem Cell Research & Therapy 2022 13:527
    Content type: Review Published on:

  11. The effects of traumatic brain injury (TBI) can include physical disability and even death. The development of effective therapies to promote neurological recovery is still a challenging problem. 3D-printed bi...

    Authors: Xiao-Yin Liu, Zhe-Han Chang, Chong Chen, Jun Liang, Jian-Xin Shi, Xiu Fan, Qi Shao, Wei-Wei Meng, Jing-Jing Wang and Xiao-Hong Li
    Citation: Stem Cell Research & Therapy 2022 13:525
    Content type: Research Published on:

  13. Heterotopic ossification (HO) is the formation of bone in non-osseous tissues, such as skeletal muscles. The HO could have a genetic or a non-genetic (acquired) background, that is, it could be caused by muscu...

    Authors: Łukasz Pulik, Bartosz Mierzejewski, Aleksandra Sibilska, Iwona Grabowska, Maria Anna Ciemerych, Paweł Łęgosz and Edyta Brzóska
    Citation: Stem Cell Research & Therapy 2022 13:523
    Content type: Review Published on:

  15. MicroRNAs (miRNAs) are non-coding single-stranded RNA molecules encoded by endogenous genes, which play a vital role in cell generation, metabolism, apoptosis and stem cell differentiation. C3H10T1/2, a mesenc...

    Authors: Wei Huang, Xiaoyue Wu, Shuaixi Xiang, Mingxin Qiao, Hanfei Li, Yujie Zhu, Zhou Zhu and Zhihe Zhao
    Citation: Stem Cell Research & Therapy 2022 13:521
    Content type: Review Published on:

  17. Mesenchymal stem cells (MSCs) driven gene directed enzyme prodrug therapy is a promising approach to deliver therapeutic agents to target heterogenous solid tumours. To democratize such a therapy, cryopreserva...

    Authors: Yoon Khei Ho, Kin Man Loke, Jun Yung Woo, Yee Lin Lee and Heng-Phon Too
    Citation: Stem Cell Research & Therapy 2022 13:519
    Content type: Research Published on:

  18. Bone-related diseases are major contributors to morbidity and mortality in elderly people and the current treatments result in insufficient healing and several complications. One of the promising areas of rese...

    Authors: Armin Ahmadi, Radman Mazloomnejad, Mohammadreza Kasravi, Babak Gholamine, Soheyl Bahrami, Mohammad Mahdi Sarzaeem and Hassan Niknejad
    Citation: Stem Cell Research & Therapy 2022 13:518
    Content type: Review Published on:

  19. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are increasingly being studied in clinical trials of end-stage liver disease because of their good tissue repair and anti-inflammatory effects. hUC-MSC ex...

    Authors: Ying Shi, Xiaoguang Yang, Shuyue Wang, Yulun Wu, Lihua Zheng, Yufang Tang, Yanhang Gao and Junqi Niu
    Citation: Stem Cell Research & Therapy 2022 13:517
    Content type: Research Published on:

  20. Endothelial progenitor cells (EPCs) contribute to the recovery of neurological function after ischemic stroke. Indirect revascularization has exhibited promising effects in the treatment of cerebral ischemia r...

    Authors: Kuo-Chuan Wang, Ling-Yu Yang, Jing-Er Lee, Vicent Wu, Te-Fu Chen, Sung-Tsang Hsieh and Meng-Fai Kuo
    Citation: Stem Cell Research & Therapy 2022 13:516
    Content type: Research Published on:

  21. Tendon regeneration is difficult because detailed knowledge about tendon progenitor cells (TPCs), which produce tenocytes to repair tendon tissue, has not been revealed. Mohawk homeobox (MKX) is a marker of TP...

    Authors: Yuki Fujisawa, Lu Ming, Daisuke Yamada, Tomoka Takao and Takeshi Takarada
    Citation: Stem Cell Research & Therapy 2022 13:515
    Content type: Short report Published on:

  24. The mesenchymal stem cells (MSCs) were used to repair tissue injury. However, the treatment effect was not satisfactory. We investigated whether lncRNA MIR155HG could promote survival and migration of MSCs und...

    Authors: Xiao Bai, Zaiwen Qi, Mingzhen Zhu, Zhuangzhuang Lu, Xin Zhao, Lining Zhang and Guangmin Song
    Citation: Stem Cell Research & Therapy 2022 13:512
    Content type: Research Published on:

  25. Bone injury plagues millions of patients worldwide every year, and it demands a heavy portion of expense from the public medical insurance system. At present, orthopedists think that autologous bone transplant...

    Authors: Yu-Hao Wang, Cheng-Zhi Zhao, Ren-Yi Wang, Qian-Xin Du, Ji-Yuan Liu and Jian Pan
    Citation: Stem Cell Research & Therapy 2022 13:511
    Content type: Review Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:524

  29. Mesenchymal stem cells (MSCs) have shown immense therapeutic potential for various brain diseases. Intrathecal administration of MSCs may enhance their recruitment to lesions in the central nervous system, but...

    Authors: Ye Ran, Yankai Dong, Yuejiao Li, Jundong Xie, Shubin Zeng, Chuanlei Liang, Wei Dai, Wenjing Tang, Yaojiong Wu and Shengyuan Yu
    Citation: Stem Cell Research & Therapy 2022 13:507
    Content type: Research Published on:

  31. Authors: Qin He, Lingshu Wang, Ruxing Zhao, Fei Yan, Sha Sha, Chen Cui, Jia Song, Huiqing Hu, Xinghong Guo, Mengmeng Yang, Yixin Cui, Yujing Sun, Zheng Sun, Fuqiang Liu, Ming Dong, Xinguo Hou…
    Citation: Stem Cell Research & Therapy 2022 13:505
    Content type: Retraction Note Published on:

  33. Cell-based therapy using adipose-derived mesenchymal stem cells (ADSCs) is a promising treatment strategy for neurogenic bladder (NB) associated with spinal cord injury (SCI). However, therapeutic efficacy is ...

    Authors: Jiasheng Chen, Lin Wang, Meng Liu, Guo Gao, Weixin Zhao, Qiang Fu and Ying Wang
    Citation: Stem Cell Research & Therapy 2022 13:503
    Content type: Research Published on:

  34. Allogeneic therapeutic cells may be rejected if they express HLA alleles not found in the recipient. As finding cell donors with a full HLA match to a recipient requires vast donor pools, the use of HLA homozy...

    Authors: Jonna Clancy, Kati Hyvärinen, Jarmo Ritari, Tiina Wahlfors, Jukka Partanen and Satu Koskela
    Citation: Stem Cell Research & Therapy 2022 13:502
    Content type: Research Published on:

  35. Human dermal fibroblasts (HDFs) have the potential to differentiate into vascular endothelial cells (VECs), but their differentiation rate is low and the mechanism involved is not clear. The small molecule pat...

    Authors: XiaoLing Cui, XiaoTan Wang, Jie Wen, Xiao Li, Nan Li, XuXiao Hao, BaoXiang Zhao, Xunwei Wu and JunYing Miao
    Citation: Stem Cell Research & Therapy 2022 13:501
    Content type: Research Published on:

  36. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important curative therapy for adult acute lymphoblastic leukemia (ALL). For patients who lack a human leukocyte antigen (HLA)-matched sibli...

    Authors: Guangyu Sun, Baolin Tang, Kaidi Song, Yue Wu, Meijuan Tu, Xiang Wan, Wen Yao, Liangquan Geng, Ping Qiang and Xiaoyu Zhu
    Citation: Stem Cell Research & Therapy 2022 13:500
    Content type: Research Published on:

  37. Localized scleroderma causes cosmetic disfigurement, joint contractures, and other functional impairment, but no currently available medications can reverse the resulting skin lesions. Fat grafting is benefici...

    Authors: Jing Wang, Junrong Cai, Qian Zhang, Jiaqing Wen, Yunjun Liao and Feng Lu
    Citation: Stem Cell Research & Therapy 2022 13:499
    Content type: Research Published on:

  38. In enteric neural stem cell (ENSC) therapy for enteric neuropathy, the gut is ostensibly accessible via laparotomy, laparoscopy or endoscopy, whereas its elongated configuration and multilayered structures sub...

    Authors: Jeng-Chang Chen
    Citation: Stem Cell Research & Therapy 2022 13:498
    Content type: Short report Published on:

  40. Microvesicles (MVs) derived from human bone marrow mesenchymal stem cell (MSC) were demonstrated to restore lung protein permeability and attenuate acute lung injury. In our previous study, we found that MSC M...

    Authors: Lifang Ye, Jieqiong Song, Yijun Zheng, Ming Zhong, Jun Liu, Duming Zhu and Shuling Hu
    Citation: Stem Cell Research & Therapy 2022 13:496
    Content type: Research Published on:

  41. The repair of cranio-maxillofacial bone defects remains a formidable clinical challenge. The Ets variant 2 (ETV2) transcription factor, which belongs to the E26 transformation-specific (ETS) family, has been r...

    Authors: Jing Li, Haoran Du, Xin Ji, Yihan Chen, Yishuai Li, Boon Chin Heng and Jianguang Xu
    Citation: Stem Cell Research & Therapy 2022 13:495
    Content type: Research Published on:

  42. Hepatic fibrosis is a common pathologic stage in chronic liver disease development, which might ultimately lead to liver cirrhosis. Accumulating evidence suggests that adipose-derived stromal cells (ADSCs)-bas...

    Authors: Baitong Wu, Jiuxing Feng, Jingyi Guo, Jian Wang, Guanghui Xiu, Jiaqi Xu, Ke Ning, Bin Ling, Qingchun Fu and Jun Xu
    Citation: Stem Cell Research & Therapy 2022 13:494
    Content type: Research Published on:

  43. Postmastectomy radiotherapy is considered to be a necessary treatment in the therapy of breast cancer, while it will cause soft tissue damage and complications, which are closely related to the success rate an...

    Authors: Haojing Tang, Yufei He, Zhuokai Liang, Jian Li, Ziqing Dong and Yunjun Liao
    Citation: Stem Cell Research & Therapy 2022 13:493
    Content type: Review Published on:

  44. Pulmonary fibrosis (PF) is a chronic and relentlessly progressive interstitial lung disease in which the accumulation of fibroblasts and extracellular matrix (ECM) induces the destruction of normal alveolar st...

    Authors: Wenzhao Cheng, Yiming Zeng and Dachun Wang
    Citation: Stem Cell Research & Therapy 2022 13:492
    Content type: Review Published on:

  45. Mesenchymal stem/stromal cells (MSCs) acquire immunosuppressive capacity only in an inflammatory microenvironment. This can be recapitulated in vitro by treating MSCs with inflammatory cytokines TNFα and IFNγ, wh...

    Authors: Chenchang Xu, Chao Feng, Peiqing Huang, Yinghong Li, Rui Liu, Chunxiao Liu, Yuyi Han, Lei Chen, Yayun Ding, Changshun Shao and Yufang Shi
    Citation: Stem Cell Research & Therapy 2022 13:491
    Content type: Research Published on:

  46. Human amniotic mesenchymal stem cells (hAMSCs) are splendid cell sources for clinical application in the administration of numerous refractory and relapse diseases. Despite the preferable prospect of serum-fre...

    Authors: Yunyan Sun, Ti-er Wang, Qianwen Hu, Wenxia Zhang, Yun Zeng, Xun Lai, Leisheng Zhang and Mingxia Shi
    Citation: Stem Cell Research & Therapy 2022 13:490
    Content type: Research Published on:

  49. Acute spinal cord injury (SCI) is a devastating result of neurological trauma with subsequent microenvironment dyshomeostasis that induces neurotoxic phenotype acquisition by astrocytes, exacerbating neurologi...

    Authors: Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu and Limin Rong
    Citation: Stem Cell Research & Therapy 2022 13:487
    Content type: Research Published on:

  50. Dental follicles are necessary for tooth eruption, surround the enamel organ and dental papilla, and regulate both the formation and resorption of alveolar bone. Dental follicle progenitor cells (DFPCs), which...

    Authors: Li Zeng, Hong He, Mingjie Sun, Xinyi Gong, Mengqi Zhou, Yaya Hong, Yongjia Wu, Xuepeng Chen and Qianming Chen
    Citation: Stem Cell Research & Therapy 2022 13:486
    Content type: Review Published on:
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Stem Cell Research & Therapy

ISSN: 1757-6512