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  1. Mesenchymal stem cell therapy for osteoarthritis (OA) has been widely investigated, but the mechanisms are still unclear. Exosomes that serve as carriers of genetic information have been implicated in many dis...

    Authors: Yafei Wang, Dongsheng Yu, Zhiming Liu, Fang Zhou, Jun Dai, Bingbing Wu, Jing Zhou, Boon Chin Heng, Xiao Hui Zou, Hongwei Ouyang and Hua Liu
    Citation: Stem Cell Research & Therapy 2017 8:189
    Content type: Research Published on:

  2. Islet dysfunction and destruction are the common cause for both type 1 and type 2 diabetes mellitus (T2DM). The islets of Langerhans are highly vascularized miniorgans, and preserving the structural integrity ...

    Authors: Lingshu Wang, Li Qing, He Liu, Na Liu, Jingting Qiao, Chen Cui, Tianyi He, Ruxing Zhao, Fuqiang Liu, Fei Yan, Chuan Wang, Kai Liang, Xinghong Guo, Ying H. Shen, Xinguo Hou and Li Chen
    Citation: Stem Cell Research & Therapy 2017 8:188
    Content type: Research Published on:

  3. Chemotherapy-induced premature ovarian failure (POF) is a severe complication affecting tumor patients at a childbearing age. Mesenchymal stem cells (MSCs) can partially restore the ovarian structure and funct...

    Authors: Xiafei Fu, Yuanli He, Xuefeng Wang, Dongxian Peng, Xiaoying Chen, Xinran Li and Qing Wang
    Citation: Stem Cell Research & Therapy 2017 8:187
    Content type: Research Published on:

  4. Human adipose-derived stem cells (hASCs) are multipotent progenitor cells with self-renewal capabilities and multilineage differentiation potential, including osteogenesis. Although protein deubiquitinases hav...

    Authors: Yiman Tang, Longwei Lv, Wenyue Li, Xiao Zhang, Yong Jiang, Wenshu Ge and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2017 8:186
    Content type: Research Published on:

  5. Lineage commitment of mesenchymal stem cells (MSCs) to cardiac differentiation is controlled by transcription factors that are regulated by epigenetic events, mainly histone deacetylation and promoter DNA meth...

    Authors: G. Bhuvanalakshmi, Frank Arfuso, Alan Prem Kumar, Arun Dharmarajan and Sudha Warrier
    Citation: Stem Cell Research & Therapy 2017 8:185
    Content type: Research Published on:

  6. Due to limitations of current angiogenesis assays, we aimed to develop a novel application of the rat aortic ring assay to assess the angiogenic potential of mesenchymal stromal cells (MSCs). First-trimester h...

    Authors: Farwah Iqbal, Peter Szaraz, Matthew Librach, Andrée Gauthier-Fisher and Clifford L. Librach
    Citation: Stem Cell Research & Therapy 2017 8:184
    Content type: Research Published on:

  7. Neovascularization is impaired in diabetes mellitus, which leads to the development of peripheral arterial disease and is mainly attributed to the dysfunction of endothelial progenitor cells (EPCs). Previous s...

    Authors: Jinzhi You, Jiacheng Sun, Teng Ma, Ziying Yang, Xu Wang, Zhiwei Zhang, Jingjing Li, Longgang Wang, Masaaki Ii, Junjie Yang and Zhenya Shen
    Citation: Stem Cell Research & Therapy 2017 8:182
    Content type: Research Published on:

  8. A hypoxic-preconditioned secretome from stem cells reportedly promotes the functional and regenerative capacity of the liver more effectively than a control secretome. However, the optimum oxygen partial press...

    Authors: Sang Chul Lee, Kee-Hwan Kim, Ok-Hee Kim, Sang Kuon Lee, Ha-Eun Hong, Seong Su Won, Sang-Jin Jeon, Byung Jo Choi, Wonjun Jeong and Say-June Kim
    Citation: Stem Cell Research & Therapy 2017 8:181
    Content type: Research Published on:

  9. Surfactant therapy has become the standard of care for preterm infants with respiratory distress syndrome. Preclinical studies have reported the therapeutic benefits of mesenchymal stem cells (MSCs) in experim...

    Authors: Chung-Ming Chen, Hsiu-Chu Chou, Willie Lin and Chris Tseng
    Citation: Stem Cell Research & Therapy 2017 8:180
    Content type: Research Published on:

  10. Chronic periodontal disease is an infectious disease consisting of prolonged inflammation of the supporting tooth tissue and resulting in bone loss. Guided bone regeneration procedures have become common and s...

    Authors: Laura Tomasello, Rodolfo Mauceri, Antonina Coppola, Maria Pitrone, Giuseppe Pizzo, Giuseppina Campisi, Giuseppe Pizzolanti and Carla Giordano
    Citation: Stem Cell Research & Therapy 2017 8:179
    Content type: Research Published on:

  11. Acquired aplastic anemia (AA) is characterized by deficiency or dysfunction of the bone marrow (BM) microenvironment. However, little is known about the impairment of BM-derived mesenchymal stem cells (MSCs) i...

    Authors: Shihong Lu, Meili Ge, Yizhou Zheng, Jianping Li, Xiaoming Feng, Sizhou Feng, Jinbo Huang, Ying Feng, Donglin Yang, Jun Shi, Fang Chen and Zhongchao Han
    Citation: Stem Cell Research & Therapy 2017 8:178
    Content type: Research Published on:

  13. Argininosuccinate synthase (ASS)1 is a urea cycle enzyme that catalyzes the conversion of citrulline and aspartate to argininosuccinate. Mutations in the ASS1 gene cause citrullinemia type I, a rare autosomal ...

    Authors: Maria Beatriz Herrera Sanchez, Sara Previdi, Stefania Bruno, Valentina Fonsato, Maria Chiara Deregibus, Sharad Kholia, Sara Petrillo, Emanuela Tolosano, Rossana Critelli, Marco Spada, Renato Romagnoli, Mauro Salizzoni, Ciro Tetta and Giovanni Camussi
    Citation: Stem Cell Research & Therapy 2017 8:176
    Content type: Research Published on:

  14. Dental pulp represents an easily accessible autologous source of adult stem cells. A subset of these cells, named dental pulp pluripotent-like stem cells (DPPSC), shows high plasticity and can undergo multiple...

    Authors: Ester Martínez-Sarrà, Sheyla Montori, Carlos Gil-Recio, Raquel Núñez-Toldrà, Domiziana Costamagna, Alessio Rotini, Maher Atari, Aernout Luttun and Maurilio Sampaolesi
    Citation: Stem Cell Research & Therapy 2017 8:175
    Content type: Research Published on:

  15. Human adult stem cells hold the potential for the cure of numerous conditions and degenerative diseases. They possess major advantages over pluripotent stem cells as they can be derived from donors at any age,...

    Authors: Raju Khatri, Michal Arad, Timothy Ortlip, Benjamin A. Portney, W. Alex Meltzer, Silviu Diaconu, Lorna E. Silipino, Ying Wang, David M. Kaetzel, Rodney J. Taylor and Michal Zalzman
    Citation: Stem Cell Research & Therapy 2017 8:174
    Content type: Research Published on:

  16. Many reports have shown that various kinds of stem cells have the ability to recover premature ovarian aging (POA) function. Transplantation of human amniotic epithelial cells (hAECs) improves ovarian function...

    Authors: Chenyue Ding, Hong Li, Yun Wang, Fuxin Wang, Huihua Wu, Rulei Chen, Jinghuan Lv, Wei Wang and Boxian Huang
    Citation: Stem Cell Research & Therapy 2017 8:173
    Content type: Research Published on:

  17. Transplantation of insulin-producing cells is considered an important diabetes therapy. Many research studies have shown that insulin-producing cells can be derived from the in-vitro cultured pancreatic coloni...

    Authors: Dongshen Ma, Shanshan Tang, Jing Song, Qiong Wu, Fangfang Zhang, Yun Xing, Yi Pan, Yanfeng Zhang, Jingwei Jiang, Yubin Zhang and Liang Jin
    Citation: Stem Cell Research & Therapy 2017 8:172
    Content type: Research Published on:

  18. Mesenchymal stromal/stem cells (MSCs) have demonstrated pro-healing properties due to their anti-inflammatory, angiogenic, and even antibacterial properties. We have shown previously that minocycline enhances ...

    Authors: Alberto Daniel Guerra, Warren E. Rose, Peiman Hematti and W. John Kao
    Citation: Stem Cell Research & Therapy 2017 8:171
    Content type: Research Published on:

  19. Keloid is one kind of benign skin disease caused by hyperplasia of fibroblasts and collagen fibrils. It is refractory due to the lack of an effective treatment at present, which puts pressure on seeking a new ...

    Authors: Ya Jiao, Xiao Wang, Jixun Zhang, Yongjun Qi, Hongmin Gong and Duyin Jiang
    Citation: Stem Cell Research & Therapy 2017 8:170
    Content type: Short report Published on:

  20. Accumulated evidence supports the potent stimulating effects of multiple small molecules on the expansion of hematopoietic stem cells (HSCs) which are important for the therapy of various hematological disorde...

    Authors: Lan Wang, Xin Guan, Huihui Wang, Bin Shen, Yu Zhang, Zhihua Ren, Yupo Ma, Xinxin Ding and Yongping Jiang
    Citation: Stem Cell Research & Therapy 2017 8:169
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:458

  21. Mesenchymal stem cells (MSCs) represent an important source for cell therapy in regenerative medicine. MSCs have shown promising results for repair of damaged tissues in various degenerative diseases in animal...

    Authors: Amruta Barhanpurkar-Naik, Suhas T. Mhaske, Satish T. Pote, Kanupriya Singh and Mohan R. Wani
    Citation: Stem Cell Research & Therapy 2017 8:168
    Content type: Research Published on:

  22. Type 1 diabetes (T1D) is a multifactorial autoimmune disorder where pancreatic beta cells are lost before the clinical manifestations of the disease. Administration of mesenchymal stem cells (MSCs) or MSCs dif...

    Authors: Anshu Sharma and Rajni Rani
    Citation: Stem Cell Research & Therapy 2017 8:167
    Content type: Research Published on:

  23. Equine mesenchymal stromal/stem cells (MSCs) are most commonly harvested from bone marrow (BM) or adipose tissue, requiring the use of surgical procedures. By contrast, the uterus can be accessed nonsurgically...

    Authors: B. Elisabeth Rink, Karin R. Amilon, Cristina L. Esteves, Hilari M. French, Elaine Watson, Christine Aurich and F. Xavier Donadeu
    Citation: Stem Cell Research & Therapy 2017 8:166
    Content type: Research Published on:

  24. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, acts as an inhibitor of angiogenesis and is associated with an increased risk of cardiovascular mortality. Administration o...

    Authors: Juraj Madaric, Martina Valachovicova, Ludovit Paulis, Jana Pribojova, Renata Mateova, Katarina Sebekova, Luba Postulkova, Terezia Madaricova, Maria Bucova, Martin Mistrik and Ivan Vulev
    Citation: Stem Cell Research & Therapy 2017 8:165
    Content type: Research Published on:

  25. Mesenchymal stem cells (MSCs) migrate via the bloodstream to sites of injury and are possibly attracted by inflammatory factors. As a proinflammatory mediator, angiotensin II (Ang II) reportedly enhances the m...

    Authors: Xiu-ping Xu, Hong-li He, Shu-ling Hu, Ji-bin Han, Li-li Huang, Jing-yuan Xu, Jian-feng Xie, Ai-ran Liu, Yi Yang and Hai-bo Qiu
    Citation: Stem Cell Research & Therapy 2017 8:164
    Content type: Research Published on:

  26. Blood-brain barrier impairment is a major indicator of endothelial dysfunction in diabetes. Studies showed that endothelial progenitor cell (EPC) transplantation promoted angiogenesis and improved function rec...

    Authors: Jieli Geng, Liping Wang, Meijie Qu, Yaying Song, Xiaojie Lin, Yajing Chen, Muyassar Mamtilahun, Shengdi Chen, Zhijun Zhang, Yongting Wang and Guo-Yuan Yang
    Citation: Stem Cell Research & Therapy 2017 8:163
    Content type: Research Published on:

  27. Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) has emerged as a novel therapy for acute liver failure (ALF). However, the homing efficiency of BMSCs to the injured liver sites appears to...

    Authors: Kun Wang, Yuwen Li, Tiantian Zhu, Yongting Zhang, Wenting Li, Wenyu Lin, Jun Li and Chuanlong Zhu
    Citation: Stem Cell Research & Therapy 2017 8:162
    Content type: Research Published on:

  28. The umbilical cord is becoming a notable alternative to bone marrow (BM) as a source of mesenchymal stromal cells (MSC). Although age-dependent variations in BM-MSC are well described, less data are available ...

    Authors: Léonore Avercenc-Léger, Philippe Guerci, Jean-Marc Virion, Ghislaine Cauchois, Sébastien Hupont, Rachid Rahouadj, Jacques Magdalou, Jean-François Stoltz, Danièle Bensoussan, Céline Huselstein and Loïc Reppel
    Citation: Stem Cell Research & Therapy 2017 8:161
    Content type: Research Published on:

  29. Human embryonic stem cells (hESCs) potentially offer new routes to study, on the basis of the Developmental Origins of Health and Disease (DOHaD) concept, how the maternal environment during pregnancy influenc...

    Authors: Maria Barandalla, Hui Shi, Hui Xiao, Silvia Colleoni, Cesare Galli, Pietro Lio, Matthew Trotter and Giovanna Lazzari
    Citation: Stem Cell Research & Therapy 2017 8:160
    Content type: Research Published on:

  30. Primary graft dysfunction (PGD) is considered to be the end result of an inflammatory response targeting the new lung allograft after transplant. Previous research has indicated that MAPC cell therapy might at...

    Authors: An Martens, Sofie Ordies, Bart M. Vanaudenaerde, Stijn E. Verleden, Robin Vos, Dirk E. Van Raemdonck, Geert M. Verleden, Valerie D. Roobrouck, Sandra Claes, Dominique Schols, Eric Verbeken, Catherine M. Verfaillie and Arne P. Neyrinck
    Citation: Stem Cell Research & Therapy 2017 8:159
    Content type: Research Published on:

  31. The development of cellular therapies to treat muscle wastage with disease or age is paramount. Resident muscle satellite cells are not currently regarded as a viable cell source due to their limited migration...

    Authors: Beverley J. Cottle, Fiona C. Lewis, Victoria Shone and Georgina M. Ellison-Hughes
    Citation: Stem Cell Research & Therapy 2017 8:158
    Content type: Research Published on:

  32. The prevalence of chronic skin wounds in humans is high, and treatment is often complicated by the presence of pathogenic bacteria. Therefore, safe and innovative treatments to reduce the bacterial load in cut...

    Authors: Rebecca M. Harman, Steven Yang, Megan K. He and Gerlinde R. Van de Walle
    Citation: Stem Cell Research & Therapy 2017 8:157
    Content type: Research Published on:

  33. Smooth muscle progenitor cells (pSMCs) differentiated from human pluripotent stem cells (hPSCs) hold great promise for treating diseases or degenerative conditions involving smooth muscle pathologies. However,...

    Authors: Yanhui Li, Yan Wen, Morgaine Green, Elise K. Cabral, Prachi Wani, Fan Zhang, Yi Wei, Thomas M. Baer and Bertha Chen
    Citation: Stem Cell Research & Therapy 2017 8:156
    Content type: Research Published on:

  34. Transplantation of cultured epidermal cell sheets (CES) has long been used to treat patients with burns, chronic wounds, and stable vitiligo. In patients with large area burns this can be a life-saving procedu...

    Authors: Catherine J. Jackson, Kim Alexander Tønseth and Tor Paaske Utheim
    Citation: Stem Cell Research & Therapy 2017 8:155
    Content type: Review Published on:

  35. Due to their “natural immune privilege” and immunoregulatory properties human fibroblast-like limbal stem cells (f-LSCs) have acquired great interest as a potential tool for achieving immunotolerance. Hashimot...

    Authors: Antonina Coppola, Laura Tomasello, Maria Pitrone, Salvatore Cillino, Pierina Richiusa, Giuseppe Pizzolanti and Carla Giordano
    Citation: Stem Cell Research & Therapy 2017 8:154
    Content type: Research Published on:

  36. Mesenchymal stem cells (MSCs) have been widely used in cytotherapy and tissue engineering due to their immunosuppressive ability and regenerative potential. Recently, the immunomodulatory influence of MSCs has...

    Authors: Yuan Yin, Rui-Xin Wu, Xiao-Tao He, Xin-Yue Xu, Jia Wang and Fa-Ming Chen
    Citation: Stem Cell Research & Therapy 2017 8:153
    Content type: Research Published on:

  37. To reduce young female fertility loss, the in-vitro culture of cryopreserved ovarian cortical tissues (OCTs) is considered an effective approach without delaying treatment and undergoing stimulation medicine. ...

    Authors: Yingxian Jia, Xiaohan Shi, Yidong Xie, Xiaochuan Xie, Yan Wang and Shangwei Li
    Citation: Stem Cell Research & Therapy 2017 8:152
    Content type: Research Published on:

  38. Asthma is a chronic inflammatory disease that can be difficult to treat due to its complex pathophysiology. Most current drugs focus on controlling the inflammatory process, but are unable to revert the change...

    Authors: Ligia Lins de Castro, Debora Gonçalves Xisto, Jamil Zola Kitoko, Fernanda Ferreira Cruz, Priscilla Christina Olsen, Patricia Albuquerque Garcia Redondo, Tatiana Paula Teixeira Ferreira, Daniel Jay Weiss, Marco Aurélio Martins, Marcelo Marcos Morales and Patricia Rieken Macedo Rocco
    Citation: Stem Cell Research & Therapy 2017 8:151
    Content type: Research Published on:

  39. Disorders of the oxidative phosphorylation (OXPHOS) system represent a large group among the inborn errors of metabolism. The most frequently observed biochemical defect is isolated deficiency of mitochondrial...

    Authors: Marlen Melcher, Katharina Danhauser, Annette Seibt, Özer Degistirici, Fabian Baertling, Arun Kumar Kondadi, Andreas S. Reichert, Werner J. H. Koopman, Peter H. G. M. Willems, Richard J. Rodenburg, Ertan Mayatepek, Roland Meisel and Felix Distelmaier
    Citation: Stem Cell Research & Therapy 2017 8:150
    Content type: Research Published on:

  40. Due to the multilineage differentiation ability and paracrine role of adipose-derived stem cells (ASCs) for bladder defect repair, various scaffolds have been applied in combination with ASCs to promote bladde...

    Authors: Qiong Wang, Dong-dong Xiao, Hao Yan, Yang Zhao, Shi Fu, Juan Zhou, Zhong Wang, Zhe Zhou, Ming Zhang and Mu-Jun Lu
    Citation: Stem Cell Research & Therapy 2017 8:149
    Content type: Research Published on:

  41. Polycaprolactone (PCL) has been regarded as a promising synthetic material for bone tissue engineering application. Owing to its unique biochemical properties and great compatibility, PCL fibers have come to b...

    Authors: Ruyue Xue, Yuna Qian, Linhao Li, Guidong Yao, Li Yang and Yingpu Sun
    Citation: Stem Cell Research & Therapy 2017 8:148
    Content type: Research Published on:

  42. Craniofacial mesenchymal stem cells (MSCs), isolated from an abundant and accessible source of craniofacial tissues, possess self-renewal and multilineage differentiation potential. It has been reported that c...

    Authors: Ruili Yang, Tingting Yu and Yanheng Zhou
    Citation: Stem Cell Research & Therapy 2017 8:147
    Content type: Review Published on:

  43. Recent studies have indicated that microRNA-223 (miR-223) plays a role in the tissue-protective effect of mesenchymal stem cells (MSCs). NLR family-pyrin domain containing 3 (NLRP3) was reported to affect a re...

    Authors: Xiaopeng Yuan, Xiaoping Wang, Chuanbao Chen, Jian Zhou and Ming Han
    Citation: Stem Cell Research & Therapy 2017 8:146
    Content type: Research Published on:

  45. In our clinical practice, we perform transplantations of autologous synovial mesenchymal stem cells (MSCs) for cartilage and meniscus regenerative medicine. One of the most important issues to ensuring clinica...

    Authors: Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yuji Kohno, Shizuka Fujii, Nobutake Ozeki, Masafumi Horie, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta and Ichiro Sekiya
    Citation: Stem Cell Research & Therapy 2017 8:144
    Content type: Research Published on:

  46. Mesenchymal stromal cells (MSCs) from various tissues have shown moderate therapeutic efficacy in reversing liver fibrosis in preclinical models. Here, we compared the relative therapeutic potential of pooled,...

    Authors: Mathiyazhagan Rengasamy, Gurbind Singh, Noor Atiqah Fakharuzi, Siddikuzzaman, Sudha Balasubramanian, Priyanka Swamynathan, Charan Thej, Gopinath Sasidharan, Pawan Kumar Gupta, Anjan Kumar Das, Ahmad Zuhairi Abd Rahman, Kamal Shaik Fakiruddin, Lim Moon Nian, Zubaidah Zakaria and Anish S. Majumdar
    Citation: Stem Cell Research & Therapy 2017 8:143
    Content type: Research Published on:

  47. The delivery of alternative myogenic cell sources to enhance the efficacy of minced muscle grafts (MG) for the treatment of volumetric muscle loss (VML) injuries is a promising strategy to overcome the demand ...

    Authors: Stephen M. Goldman, Beth E. P. Henderson and Benjamin T. Corona
    Citation: Stem Cell Research & Therapy 2017 8:142
    Content type: Short report Published on:

  48. A number of studies have shown that tooth-like structures can be regenerated using induced pluripotent stem cells and mouse embryonic stem (mES) cells. However, few studies have reported the regeneration of to...

    Authors: Yancong Zhang, Yongliang Li, Ruirui Shi, Siqi Zhang, Hao Liu, Yunfei Zheng, Yan Li, Jinglei Cai, Duanqing Pei and Shicheng Wei
    Citation: Stem Cell Research & Therapy 2017 8:141
    Content type: Research Published on:

  49. Mesenchymal stromal cells (MSC) possess immunomodulatory properties and low immunogenicity, both crucial properties for their development into an effective cellular immunotherapy. They have shown benefit in cl...

    Authors: Samantha F. H. de Witte, Ana M. Merino, Marcella Franquesa, Tanja Strini, Johanna A. A. van Zoggel, Sander S. Korevaar, Franka Luk, Madhu Gargesha, Lisa O’Flynn, Debashish Roy, Steve J. Elliman, Philip N. Newsome, Carla C. Baan and Martin J. Hoogduijn
    Citation: Stem Cell Research & Therapy 2017 8:140
    Content type: Research Published on:

  50. Mechanical stimuli play important roles in the proliferation and differentiation of adult stem cells. However, few studies on their effects on induced pluripotent stem cells (iPSCs) have been published.

    Authors: Young Mi Kim, Yun Gyeong Kang, So Hee Park, Myung-Kwan Han, Jae Ho Kim, Ji Won Shin and Jung-Woog Shin
    Citation: Stem Cell Research & Therapy 2017 8:139
    Content type: Research Published on:
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