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  1. Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis in Asia. Japanese encephalitis (JE) caused by JEV is characterized by extensive inflammatory cytokine secretion, microglia activatio...

    Authors: Peiyu Bian, Chuantao Ye, Xuyang Zheng, Jing Yang, Wei Ye, Yuan Wang, Yun Zhou, Hongwei Ma, Peijun Han, Hai Zhang, Ying Zhang, Fanglin Zhang, Yingfeng Lei and Zhansheng Jia
    Citation: Stem Cell Research & Therapy 2017 8:38
    Content type: Research Published on:

  2. First trimester (FTM) and term human umbilical cord-derived perivascular cells (HUCPVCs), which are rich sources of mesenchymal stem cells (MSCs), can give rise to Sertoli cell (SC)-like as well as haploid ger...

    Authors: Ekaterina Shlush, Leila Maghen, Sonja Swanson, Shlomit Kenigsberg, Sergey Moskovtsev, Tanya Barretto, Andrée Gauthier-Fisher and Clifford L. Librach
    Citation: Stem Cell Research & Therapy 2017 8:37
    Content type: Research Published on:

  3. Heart failure represents an important public health issue due to its high costs and growing incidence worldwide. Evidence showing the regenerative potential of postmitotic heart tissue has suggested the existe...

    Authors: Taís Hanae Kasai-Brunswick, Andréa Rodrigues da Costa, Raiana Andrade Quintanilha Barbosa, Bruna Farjun, Fernanda Cristina Paccola Mesquita, Danúbia Silva dos Santos, Isalira Peroba Ramos, Grazielle Suhett, Guilherme Visconde Brasil, Sandro Torrentes da Cunha, José Oscar R. Brito, Juliana do Amaral Passipieri, Adriana Bastos Carvalho and Antonio Carlos Campos de Carvalho
    Citation: Stem Cell Research & Therapy 2017 8:36
    Content type: Research Published on:

  5. Cell-based gene therapy has become a subject of interest for the treatment of pulmonary arterial hypertension (PAH), a devastating disease characterized by pulmonary artery smooth muscle cell (PASMC) hyperplas...

    Authors: Gesheng Cheng, Xingye Wang, Yongxin Li and Lu He
    Citation: Stem Cell Research & Therapy 2017 8:34
    Content type: Research Published on:

  6. CD133+ stem cells represent a promising subpopulation for innovative cell-based therapies in cardiovascular regeneration. Several clinical trials have shown remarkable beneficial effects following their intramyoc...

    Authors: Anna Skorska, Paula Müller, Ralf Gaebel, Jana Große, Heiko Lemcke, Cornelia A. Lux, Manuela Bastian, Frauke Hausburg, Nicole Zarniko, Sandra Bubritzki, Ulrike Ruch, Gudrun Tiedemann, Robert David and Gustav Steinhoff
    Citation: Stem Cell Research & Therapy 2017 8:33
    Content type: Research Published on:

  8. The study of lipid metabolism in stem cell physiology has recently raised great interest. The role of lipids goes beyond the mere structural involvement in assembling extra- and intra-cellular compartments. Ne...

    Authors: Alexandros Chatgilialoglu, Martina Rossi, Francesco Alviano, Paola Poggi, Chiara Zannini, Cosetta Marchionni, Francesca Ricci, Pier Luigi Tazzari, Valentina Taglioli, Philip C. Calder and Laura Bonsi
    Citation: Stem Cell Research & Therapy 2017 8:31
    Content type: Research Published on:

  9. Mesenchymal stem cells (MSCs) are the most promising cell types for bone regeneration and repair due to their osteogenic potential. MSC differentiation is precisely regulated and orchestrated by the mechanical...

    Authors: Wenyuan Zhang, Rui Dong, Shu Diao, Juan Du, Zhipeng Fan and Fu Wang
    Citation: Stem Cell Research & Therapy 2017 8:30
    Content type: Research Published on:

  10. Bone marrow mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) are used to repair hypoxic or ischemic tissue. However, the underlining mechanism of resistance in the hypoxic microenvironment...

    Authors: Cheng Liu, An-Ly Tsai, Ping-Chia Li, Chia-Wei Huang and Chia-Ching Wu
    Citation: Stem Cell Research & Therapy 2017 8:29
    Content type: Research Published on:

  12. Stem cells are capable of unlimited self-renewal and are able to remain undifferentiated for extended periods of time prior to their differentiation into specific cell lineages. Because of the issues (ethical ...

    Authors: Jéssica Borghesi, Lara Carolina Mario, Ana Claudia Oliveira Carreira, Maria Angélica Miglino and Phelipe Oliveira Favaron
    Citation: Stem Cell Research & Therapy 2017 8:27
    Content type: Research Published on:

  13. Neonatal hypoxia-ischemia induces massive brain damage during the perinatal period, resulting in long-term consequences to central nervous system structural and functional maturation. Although neural progenito...

    Authors: Feifei Wang, Nobuyasu Baba, Yuan Shen, Tatsuyuki Yamashita, Emi Tsuru, Masayuki Tsuda, Nagamasa Maeda and Yusuke Sagara
    Citation: Stem Cell Research & Therapy 2017 8:26
    Content type: Research Published on:

  14. Transplantation of endothelial progenitor cells (EPCs)/endothelial cells (ECs) has been used for the treatment of ischemic diseases and hemophilia A, due to their great capacity for producing factor VIII and f...

    Authors: Meng Qin, Xin Guan, Huihui Wang, Yu Zhang, Bin Shen, Qingyu Zhang, Wei Dai, Yupo Ma and Yongping Jiang
    Citation: Stem Cell Research & Therapy 2017 8:25
    Content type: Research Published on:

  15. Mesenchymal stromal cells (MSCs) and renal stem/progenitors improve the recovery of acute kidney injury (AKI) mainly through the release of paracrine mediators including the extracellular vesicles (EVs). Sever...

    Authors: Andrea Ranghino, Stefania Bruno, Benedetta Bussolati, Aldo Moggio, Veronica Dimuccio, Marta Tapparo, Luigi Biancone, Paolo Gontero, Bruno Frea and Giovanni Camussi
    Citation: Stem Cell Research & Therapy 2017 8:24
    Content type: Research Published on:

  16. Adipose-derived stem cells (ADSCs) are emerging as an alternative stem cell source for cell-based therapies. Recent data suggest that autologous ADSC-enriched micrografting improves the effects of facial invol...

    Authors: Michelle Griffin, Caroline M. Ryan, Omar Pathan, David Abraham, Christopher P. Denton and Peter E. M. Butler
    Citation: Stem Cell Research & Therapy 2017 8:23
    Content type: Research Published on:

  17. The purpose of this study was to investigate the therapeutic efficacy of intravenously administered immunoselected STRO-3 + mesenchymal precursor cells (MPCs) on clinical scores, joint pathology and cytokine p...

    Authors: Anwar Abdalmula, Laura M. Dooley, Claire Kaufman, Elizabeth A. Washington, Jacqueline V. House, Barbara A. Blacklaws, Peter Ghosh, Silviu Itescu, Simon R. Bailey and Wayne G. Kimpton
    Citation: Stem Cell Research & Therapy 2017 8:22
    Content type: Research Published on:

  18. Mesenchymal stromal cells (MSCs) are considered to have a modest benefit on left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction (AMI). However, the optimal injection timing a...

    Authors: Zi Wang, Lingling Wang, Xuan Su, Jun Pu, Meng Jiang and Ben He
    Citation: Stem Cell Research & Therapy 2017 8:21
    Content type: Research Published on:

  19. The liver has the remarkable capacity to regenerate in order to compensate for lost or damaged hepatic tissue. However, pre-existing pathological abnormalities, such as hepatic steatosis (HS), inhibits the end...

    Authors: Fernando Ezquer, Javiera Bahamonde, Ya-Lin Huang and Marcelo Ezquer
    Citation: Stem Cell Research & Therapy 2017 8:20
    Content type: Research Published on:

  20. Mesenchymal stromal cells (MSCs) represent an option for the treatment of acute kidney injury (AKI). It is known that young stem cells are better than are aged stem cells at reducing the incidence of the senes...

    Authors: Camila Eleuterio Rodrigues, José Manuel Condor Capcha, Ana Carolina de Bragança, Talita Rojas Sanches, Priscila Queiroz Gouveia, Patrícia Aparecida Ferreira de Oliveira, Denise Maria Avancini Costa Malheiros, Rildo Aparecido Volpini, Mirela Aparecida Rodrigues Santinho, Bárbara Amélia Aparecida Santana, Rodrigo do Tocantins Calado, Irene de Lourdes Noronha and Lúcia Andrade
    Citation: Stem Cell Research & Therapy 2017 8:19
    Content type: Research Published on:

  21. Stem cells provide a promising candidate for the treatment of the fatal pediatric dilated cardiomyopathy (DCM). This study aimed to investigate the effects of intramuscular injection of human umbilical cord-de...

    Authors: Chenggang Mao, Xu Hou, Benzhen Wang, Jingwei Chi, Yanjie Jiang, Caining Zhang and Zipu Li
    Citation: Stem Cell Research & Therapy 2017 8:18
    Content type: Research Published on:

  22. Transplantation of cardiosphere-derived cells (CDCs) has been shown to exert a therapeutic effect in patients with myocardial infarction (MI). However, poor survival of transplanted CDCs limits their beneficia...

    Authors: Rongchuan Yue, Wenbin Fu, Xiang Liao, Cong Lan, Qiao Liao, Liangpeng Li, Dezhong Yang, Xuewei Xia, Xiongwen Chen, Chunyu Zeng and Wei Eric Wang
    Citation: Stem Cell Research & Therapy 2017 8:17
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:530

  23. The native articular cartilage lacks the ability to heal. Currently, ex vivo expanded chondrocytes or bone marrow-derived mesenchymal stem cells are used to regenerate the damaged cartilage. With unlimited sel...

    Authors: Yoojun Nam, Yeri Alice Rim, Seung Min Jung and Ji Hyeon Ju
    Citation: Stem Cell Research & Therapy 2017 8:16
    Content type: Research Published on:

  24. Metabolic plasticity and the versatility of different lineages of stem cells as they satisfy their energy demands are not completely understood. In this study we investigated the metabolic changes in mesenchym...

    Authors: Aleksandra V. Meleshina, Varvara V. Dudenkova, Alena S. Bystrova, Daria S. Kuznetsova, Marina V. Shirmanova and Elena V. Zagaynova
    Citation: Stem Cell Research & Therapy 2017 8:15
    Content type: Research Published on:

  25. Increasing evidence suggests the safety and efficacy of mesenchymal stromal cells (MSC) as advanced therapy medicinal products because of their immunomodulatory properties and supportive role in hematopoiesis....

    Authors: Eliana Amati, Sabrina Sella, Omar Perbellini, Alberta Alghisi, Martina Bernardi, Katia Chieregato, Chiara Lievore, Denise Peserico, Manuela Rigno, Anna Zilio, Marco Ruggeri, Francesco Rodeghiero and Giuseppe Astori
    Citation: Stem Cell Research & Therapy 2017 8:14
    Content type: Research Published on:

  26. Transcription factor-mediated reprogramming can reset the epigenetics of somatic cells into a pluripotency compatible state. Recent studies show that induced pluripotent stem cells (iPSCs) always inherit start...

    Authors: Shuai Gao, Xinfeng Hou, Yonghua Jiang, Zijian Xu, Tao Cai, Jiajie Chen and Gang Chang
    Citation: Stem Cell Research & Therapy 2017 8:13
    Content type: Research Published on:

  27. Acute necrotizing pancreatitis (ANP) is often complicated by multiple organ failure. The small intestine is frequently damaged during ANP. Capillary leakage in multiple organs during ANP is one of the most imp...

    Authors: Fengchun Lu, Feng Wang, Zhiyao Chen and Heguang Huang
    Citation: Stem Cell Research & Therapy 2017 8:12
    Content type: Research Published on:

  28. Young female patients who receive chemotherapy frequently face premature ovarian failure (POF). The therapeutic potential of stem cells in these patients has been explored in stem cells derived from different ...

    Authors: Zhen Wang, Yueling Wang, Ting Yang, Jing Li and Xinyuan Yang
    Citation: Stem Cell Research & Therapy 2017 8:11
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2017 8:49

  29. Adequate vascularization is crucial for supplying nutrition and discharging metabolic waste in freshly transplanted tissue-engineered constructs. Obtaining the appropriate building blocks for vascular tissue e...

    Authors: Jian Guang Xu, Shao Yue Zhu, Boon Chin Heng, Waruna Lakmal Dissanayaka and Cheng Fei Zhang
    Citation: Stem Cell Research & Therapy 2017 8:10
    Content type: Research Published on:

  30. Human menstrual blood-derived stem cells (MenSCs) are a novel source of MSCs that provide the advantage of being easy to collect and isolate. Exosomes contain some mRNAs and adhesion molecules that can potenti...

    Authors: Lu Chen, Bingyu Xiang, Xiaojun Wang and Charlie Xiang
    Citation: Stem Cell Research & Therapy 2017 8:9
    Content type: Research Published on:

  31. In a previous study, we demonstrated that intravenous administration of adipose tissue stem cells (ASCs) could significantly reduce allergic symptoms and suppress eosinophilic inflammation.

    Authors: Hak Sun Yu, Mi-Kyung Park, Shin Ae Kang, Kyu-Sup Cho, Sue Jean Mun and Hwan-Jung Roh
    Citation: Stem Cell Research & Therapy 2017 8:8
    Content type: Research Published on:

  32. The hematopoietic system is especially sensitive to total body irradiation (TBI), and myelosuppression is one of the major effects of TBI. Astaxanthin (ATX) is a powerful natural anti-oxidant with low toxicity...

    Authors: Xiao-Lei Xue, Xiao-Dan Han, Yuan Li, Xiao-Fei Chu, Wei-Min Miao, Jun-Ling Zhang and Sai-Jun Fan
    Citation: Stem Cell Research & Therapy 2017 8:7
    Content type: Research Published on:

  33. Generation of large quantities of endothelial cells is highly desirable for vascular research, for the treatment of ischemia diseases, and for tissue regeneration. To achieve this goal, we developed a simple, ...

    Authors: Fengzhi Zhang, Lin Wang, Yaqian Li, Wei Liu, Fuyu Duan, Rujin Huang, Xi Chen, Sophia Chia-Ning Chang, Yanan Du and Jie Na
    Citation: Stem Cell Research & Therapy 2017 8:6
    Content type: Research Published on:

  34. Mesenchymal stromal cells (MSCs) and Ophiophagus hannah l-amino acid oxidase (Oh-LAAO) have been reported to exhibit antimicrobial activity against methicillin-resistant Staphylococcus...

    Authors: Yee Yik Mot, Iekhsan Othman and Syed Hassan Sharifah
    Citation: Stem Cell Research & Therapy 2017 8:5
    Content type: Research Published on:

  35. Mesenchymal stem cells (MSCs) have limited potential of cardiogenic differentiation. In this study, we investigated the influence of long noncoding RNA Braveheart (lncRNA-Bvht) on cardiogenic differentiation o...

    Authors: Jingying Hou, Huibao Long, Changqing Zhou, Shaoxin Zheng, Hao Wu, Tianzhu Guo, Quanhua Wu, Tingting Zhong and Tong Wang
    Citation: Stem Cell Research & Therapy 2017 8:4
    Content type: Research Published on:

  36. Human bone marrow-derived mesenchymal stem cells (MSC) are adult progenitor cells with great potential for application in cell-based therapies. From a cell-based therapy perspective, there are two limitations ...

    Authors: Alessandro Bertolo, Simona Capossela, Gion Fränkl, Martin Baur, Tobias Pötzel and Jivko Stoyanov
    Citation: Stem Cell Research & Therapy 2017 8:3
    Content type: Research Published on:

  37. We have previously reported that induced pluripotent stem cell (iPSC)-mesenchymal stem cells (MSCs) alleviated asthma inflammation in mice. Long noncoding RNAs (lncRNAs) were recently reported as being involve...

    Authors: Shu-Yue Wang, Xing-Liang Fan, Qiu-Ning Yu, Meng-Xia Deng, Yue-Qi Sun, Wen-Xiang Gao, Cheng-Lin Li, Jian-Bo Shi and Qing-Ling Fu
    Citation: Stem Cell Research & Therapy 2017 8:2
    Content type: Research Published on:

  38. Cell therapy for intrinsic urinary sphincter deficiency (ISD) in women has been moderately effective, and improvements are needed. To improve treatment efficacy, it is important to better understand determinat...

    Authors: James Koudy Williams, Ashley Dean, Shannon Lankford, Tracy Criswell, Gopal Badlani and Karl-Erik Andersson
    Citation: Stem Cell Research & Therapy 2017 8:1
    Content type: Research Published on:

  39. Despite diverse pathogenesis, the common pathological change observed in age-related macular degeneration and in most hereditary retinal degeneration (RD) diseases is photoreceptor loss. Photoreceptor replacem...

    Authors: Xi Chen, Zehua Chen, Zhengya Li, Chen Zhao, Yuxiao Zeng, Ting Zou, Caiyun Fu, Xiaoli Liu, Haiwei Xu and Zheng Qin Yin
    Citation: Stem Cell Research & Therapy 2016 7:191
    Content type: Research Published on:

  40. Human embryonic stem cells (hESCs) partially recapitulate early embryonic three germ layer development, allowing testing of potential teratogenic hazards. Because use of hESCs is ethically debated, we investig...

    Authors: Vaibhav Shinde, Sureshkumar Perumal Srinivasan, Margit Henry, Tamara Rotshteyn, Jürgen Hescheler, Jörg Rahnenführer, Marianna Grinberg, Johannes Meisig, Nils Blüthgen, Tanja Waldmann, Marcel Leist, Jan Georg Hengstler and Agapios Sachinidis
    Citation: Stem Cell Research & Therapy 2016 7:190
    Content type: Research Published on:

  41. Although promising for graft-versus-host disease (GvHD) treatment, MSC therapy still faces important challenges. For instance, increasing MSC migratory capacity as well as potentializing immune response suppre...

    Authors: Martha Oliveira-Bravo, Bruno Braga Sangiorgi, Josiane Lilian dos Santos Schiavinato, Juliana Lott Carvalho, Dimas Tadeu Covas, Rodrigo Alexandre Panepucci, Francisco de Assis Rocha Neves, Octávio Luiz Franco, Rinaldo Wellerson Pereira and Felipe Saldanha-Araujo
    Citation: Stem Cell Research & Therapy 2016 7:189
    Content type: Research Published on:

  42. The functionality of stem cells is tightly regulated by cues from the niche, comprising both intrinsic and extrinsic cell signals. Besides chemical and growth factors, biophysical signals are important compone...

    Authors: Lekshmi Krishna, Kamesh Dhamodaran, Chaitra Jayadev, Kaushik Chatterjee, Rohit Shetty, S. S. Khora and Debashish Das
    Citation: Stem Cell Research & Therapy 2016 7:188
    Content type: Review Published on:

  43. Babies born to mothers with pregestational diabetes have a high risk for congenital heart defects (CHD). Embryonic stem cells (ESCs) are excellent in vitro models for studying the effect of high glucose on car...

    Authors: Penghua Yang, Xi Chen, Sunjay Kaushal, E. Albert Reece and Peixin Yang
    Citation: Stem Cell Research & Therapy 2016 7:187
    Content type: Research Published on:

  44. Certain early-phase clinical trials have suggested that bone marrow-derived stem cell transplantation might improve left ventricular function in patients with non-ischaemic dilated cardiomyopathy (NIDCM), wher...

    Authors: Yi Lu, Yiqin Wang, Menglu Lin, Jiale Zhou, Zi Wang, Meng Jiang and Ben He
    Citation: Stem Cell Research & Therapy 2016 7:186
    Content type: Research Published on:

  45. Cartilage formation from self-assembling mesenchymal stem cells (MSCs) in vitro recapitulate important cellular events during mesenchymal condensation that precedes native cartilage development. The goal of th...

    Authors: Johnathan Ng, Yiyong Wei, Bin Zhou, Aonnicha Burapachaisri, Edward Guo and Gordana Vunjak-Novakovic
    Citation: Stem Cell Research & Therapy 2016 7:183
    Content type: Research Published on:

  46. Cartilage does not have the capability to regenerate itself. Therefore, stem cell transplantation is a promising therapeutic approach for impaired cartilage. For stem cell transplantation, in vitro enrichment ...

    Authors: Yeonsue Jang, Hyerin Jung, Yoojun Nam, Yeri Alice Rim, Juryun Kim, Sang Hoon Jeong and Ji Hyeon Ju
    Citation: Stem Cell Research & Therapy 2016 7:184
    Content type: Research Published on:

  47. Tid1 is a mitochondrial co-chaperone protein and its transcript is abundantly expressed in skeletal muscle tissues. However, the physiological function of Tid1 during skeletal myogenesis remains unclear.

    Authors: Li-Hao Cheng, Kai-Feng Hung, Te-Chang Lee, Chih-Yang Huang, Wen-Ting Chiu, Jeng-Fan Lo and Tung-Fu Huang
    Citation: Stem Cell Research & Therapy 2016 7:185
    Content type: Research Published on:

  48. Nitric oxide (NO) plays a role in a number of physiological processes including stem cell differentiation and osteogenesis. Endothelial nitric oxide synthase (eNOS), one of three NO-producing enzymes, is locat...

    Authors: Nadeeka Bandara, Saliya Gurusinghe, Shiang Yong Lim, Haying Chen, Shuangfeng Chen, Dawei Wang, Bryan Hilbert, Le-Xin Wang and Padraig Strappe
    Citation: Stem Cell Research & Therapy 2016 7:182
    Content type: Research Published on:

  49. Although the unconjugated secondary bile acids, specifically deoxycholic acid (DCA) and lithocholic acid (LCA), are considered to be risk factors for colorectal cancer, the precise mechanism(s) by which they r...

    Authors: Lulu Farhana, Pratima Nangia-Makker, Evan Arbit, Kathren Shango, Sarah Sarkar, Hamidah Mahmud, Timothy Hadden, Yingjie Yu and Adhip P. N. Majumdar
    Citation: Stem Cell Research & Therapy 2016 7:181
    Content type: Research Published on:

  50. Epithelial to mesenchymal transition, especially to myofibroblasts, plays an important role in wound healing, fibrosis, and carcinogenesis. Epidermal stem cells (EpSCs) are responsible for epidermal renewal an...

    Authors: Haisheng Li, Zhihui Yao, Weifeng He, Hongyan Gao, Yang Bai, Sisi Yang, Lu Zhang, Rixing Zhan, Jianglin Tan, Junyi Zhou, Masao Takata, Jun Wu and Gaoxing Luo
    Citation: Stem Cell Research & Therapy 2016 7:175
    Content type: Research Published on:
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