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  1. Osteoporosis is a syndrome of excessive skeletal fragility characterized by the loss of mass and deterioration of microarchitecture in bone. Single use of aspirin or adipose-derived stromal cells (ASCs) has be...

    Authors: Hao Liu, Wei Li, Yunsong Liu, Xiao Zhang and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2015 6:200
    Content type: Research Published on:

  2. Sepsis is a clinical syndrome associated with a severe systemic inflammation induced by infection. Although different anti-microbial drugs have been used as treatments, morbidity and mortality rates remain hig...

    Authors: Francisca Alcayaga-Miranda, Jimena Cuenca, Aldo Martin, Luis Contreras, Fernando E. Figueroa and Maroun Khoury
    Citation: Stem Cell Research & Therapy 2015 6:199
    Content type: Research Published on:

  3. Cancer stem cells (CSCs) possess characteristics associated with normal stem cells, specifically the abilities to renew themselves and to give rise to all cell types (differentiation). It is assumed that induc...

    Authors: Shuqiang Yuan, Yunxin Lu, Jing Yang, Gang Chen, Sangbae Kim, Li Feng, Marcia Ogasawara, Naima Hammoudi, Weiqin Lu, Hui Zhang, Jinyun Liu, Howard Colman, Ju-Seog Lee, Xiao-Nan Li, Rui-hua Xu, Peng Huang…
    Citation: Stem Cell Research & Therapy 2015 6:198
    Content type: Research Published on:

  5. There is a clinical need for developing systemic transplantation protocols for use of human skeletal stem cells (also known bone marrow stromal stem cells) (hBMSC) in tissue regeneration. In systemic transplan...

    Authors: Rikke K. Andersen, Walid Zaher, Kenneth H. Larsen, Nicholas Ditzel, Katharina Drews, Wasco Wruck, James Adjaye, Basem M. Abdallah and Moustapha Kassem
    Citation: Stem Cell Research & Therapy 2015 6:196
    Content type: Research Published on:

  6. Mesenchymal stem cell (MSC)-based therapies have had positive outcomes both in animal models of cardiovascular diseases and in clinical patients. However, the number and function of MSCs decline during hypoxia...

    Authors: Fengyun Zhang, Jinjin Cui, Xiaojing Liu, Bo Lv, Xinxin Liu, Zulong Xie and Bo Yu
    Citation: Stem Cell Research & Therapy 2015 6:195
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:331

  7. Mesenchymal stem cells (MSCs) are of particular interest for the treatment of immune-related diseases because of their immunosuppressive capacities. However, few clinical trials of MSCs have yielded satisfacto...

    Authors: Myoung Woo Lee, Somi Ryu, Dae Seong Kim, Ki Woong Sung, Hong Hoe Koo and Keon Hee Yoo
    Citation: Stem Cell Research & Therapy 2015 6:179
    Content type: Review Published on:

  8. The goal of cancer chemotherapy is targeting tumor cells and/or tumor-associated microvessels with the lowest systemic toxicity. Mesenchymal stromal cells (MSCs) are promising vehicles for selective drug deliv...

    Authors: Simone Pacioni, Quintino Giorgio D’Alessandris, Stefano Giannetti, Liliana Morgante, Ivana De Pascalis, Valentina Coccè, Arianna Bonomi, Luisa Pascucci, Giulio Alessandri, Augusto Pessina, Maria Laura Falchetti and Roberto Pallini
    Citation: Stem Cell Research & Therapy 2015 6:194
    Content type: Research Published on:

  9. The generation of functional hepatocytes is a major challenge for regenerative medicine and drug discovery. Here we show a method that facilitates generation of induced functional hepatocytes (iHeps) from adip...

    Authors: Fen Xu, Junli Liu, Jie Deng, Xiaolei Chen, Yuan Wang, Pengchao Xu, Lin Cheng, Yanli Fu, Fuyi Cheng, Yunqi Yao, Yujing Zhang, Meijuan Huang, Dechao Yu, Yuquan Wei and Hongxin Deng
    Citation: Stem Cell Research & Therapy 2015 6:193
    Content type: Method Published on:

  10. Regenerative medicine studies using autologous bone marrow mononuclear cells (BM-MNCs) have shown improved clinical outcomes that correlate to in vitro BM-MNC invasive capacity. The current Boyden-chamber assay f...

    Authors: Michael J. Rutten, Bryan Laraway, Cynthia R. Gregory, Hua Xie, Christian Renken, Charles Keese and Kenton W. Gregory
    Citation: Stem Cell Research & Therapy 2015 6:192
    Content type: Method Published on:

  12. Mesenchymal stem cells (MSCs) are widely considered to hold promise for the treatment of intervertebral disc (IVD) degeneration. However, variation in the therapeutic efficacy of MSCs is a major problem and th...

    Authors: Jongchan Ahn, Eun-mi Park, Byeong Ju Kim, Jin-Soo Kim, Bogyu Choi, Soo-Hong Lee and Inbo Han
    Citation: Stem Cell Research & Therapy 2015 6:190
    Content type: Research Published on:

  14. Mesenchymal stem cells (MSC) are well described for their role in tissue regeneration following injury. Migratory properties of endogenous or administrated MSC are critical for tissue repair processes. Platele...

    Authors: Valérie Chabot, Cécile Dromard, Angélique Rico, Alain Langonné, Julien Gaillard, Fabien Guilloton, Louis Casteilla and Luc Sensebé
    Citation: Stem Cell Research & Therapy 2015 6:188
    Content type: Research Published on:

  15. The blood–brain barrier (BBB) protects the brain against potentially neurotoxic molecules in the circulation, and loss of its integrity may contribute to disease progression in neurodegenerative conditions. Re...

    Authors: Hyun Jung Park, Jin Young Shin, Ha Na Kim, Se Hee Oh, Sook K. Song and Phil Hyu Lee
    Citation: Stem Cell Research & Therapy 2015 6:187
    Content type: Research Published on:

  16. Despite attempts to prevent brain injury during the hyperacute phase of stroke, most sufferers end up with significant neuronal loss and functional deficits. The use of cell-based therapies to recover the inju...

    Authors: Hima C. S. Abeysinghe, Laita Bokhari, Anita Quigley, Mahesh Choolani, Jerry Chan, Gregory J. Dusting, Jeremy M. Crook, Nao R. Kobayashi and Carli L. Roulston
    Citation: Stem Cell Research & Therapy 2015 6:186
    Content type: Research Published on:

  17. The prevalence of renal fibrosis is higher in older than in younger individuals. Through paracrine activity, bone marrow mesenchymal stem cell-derived microvesicles (BM-MSC-MVs) influence the process of renal ...

    Authors: Yan Wang, Bo Fu, Xuefeng Sun, Diangeng Li, Qi Huang, Weihong Zhao and Xiangmei Chen
    Citation: Stem Cell Research & Therapy 2015 6:185
    Content type: Research Published on:

  18. Allogenic dendritic cells (DCs) generated from healthy donors, who are complete or partially HLA-matched, have been used for clinical trials. One of the sources for allogenic DCs is umbilical cord blood (UCB) ...

    Authors: Jeetendra Kumar, Vaijayanti Kale and Lalita Limaye
    Citation: Stem Cell Research & Therapy 2015 6:184
    Content type: Research Published on:

  20. Therapy-associated onset of stemness-maintenance in surviving tumor-cells dictates tumor relapse/recurrence. Recently, we recognized the anti-pancreatic cancer (PC) potential of seaweed polyphenol manifolds an...

    Authors: Sheeja Aravindan, Satish Kumar Ramraj, Somasundaram T. Somasundaram, Terence S. Herman and Natarajan Aravindan
    Citation: Stem Cell Research & Therapy 2015 6:182
    Content type: Research Published on:

  21. Mesenchymal stem cells (MSCs) are adult multipotent stem cells that possess regenerative and immunomodulatory properties. They have been widely investigated as therapeutic agents for a variety of disease condi...

    Authors: Linan Liu, Shirley X. Zhang, Rangoli Aeran, Wenbin Liao, Mengrou Lu, George Polovin, Egest J. Pone and Weian Zhao
    Citation: Stem Cell Research & Therapy 2015 6:181
    Content type: Research Published on:

  22. Authors: Yang Yu, Qian Gao, Hong-cui Zhao, Rong Li, Jiang-man Gao, Ting Ding, Si-yu Bao, Yue Zhao, Xiao-fang Sun, Yong Fan and Jie Qiao
    Citation: Stem Cell Research & Therapy 2015 6:180
    Content type: Erratum Published on:

    The original article was published in Stem Cell Research & Therapy 2015 6:69

  23. In recent years, cancer stem cells (CSCs)/tumor initiating cells (TICs) have been identified inside different tumors. However, currently used anti-cancer therapies are mostly directed against somatic tumor cel...

    Authors: Mohammed I. Khan, Anna M. Czarnecka, Igor Helbrecht, Ewa Bartnik, Fei Lian and Cezary Szczylik
    Citation: Stem Cell Research & Therapy 2015 6:178
    Content type: Review Published on:

  24. Glaucoma is a sight-threatening retinal neuropathy associated with elevated intraocular pressure (IOP) due to degeneration and fibrosis of the trabecular meshwork (TM). Glaucoma medications aim to reduce IOP w...

    Authors: Christophe Roubeix, David Godefroy, Céline Mias, Anaïs Sapienza, Luisa Riancho, Julie Degardin, Valérie Fradot, Ivana Ivkovic, Serge Picaud, Florian Sennlaub, Alexandre Denoyer, William Rostene, José Alain Sahel, Stéphane Melik Parsadaniantz, Françoise Brignole-Baudouin and Christophe Baudouin
    Citation: Stem Cell Research & Therapy 2015 6:177
    Content type: Research Published on:

  25. Stem cell-based therapies are currently widely explored as a tool to treat neuroimmune diseases. Multipotent adult progenitor cells (MAPC) have been suggested to have strong immunomodulatory and neuroprotectiv...

    Authors: Stylianos Ravanidis, Jeroen F. J. Bogie, Raf Donders, David Craeye, Robert W. Mays, Robert Deans, Kristel Gijbels, Annelies Bronckaers, Piet Stinissen, Jef Pinxteren and Niels Hellings
    Citation: Stem Cell Research & Therapy 2015 6:176
    Content type: Research Published on:

  26. Hematopoietic stem/progenitor cells (HSPCs) reside in a tightly controlled local microenvironment called bone marrow niche. The specialized microenvironment or niche not only provides a favorable habitat for H...

    Authors: Sidan Li, Dehui Zou, Changhong Li, Hengxing Meng, Weiwei Sui, Sizhou Feng, Tao Cheng, Qiongli Zhai and Lugui Qiu
    Citation: Stem Cell Research & Therapy 2015 6:175
    Content type: Research Published on:

  27. Despite the success of interventional processes such as drug-eluting stents, complete prevention of restenosis is still hindered by impaired or delayed endothelialization or both. Here, we report that 1H-pyrrole-...

    Authors: Byeong-Wook Song, Il-Kwon Kim, Seahyoung Lee, Eunhyun Choi, Onju Ham, Se-Yeon Lee, Chang Yeon Lee, Jun-Hee Park, Jiyun Lee, Hyang-Hee Seo, Woochul Chang, Cheesoon Yoon and Ki-Chul Hwang
    Citation: Stem Cell Research & Therapy 2015 6:174
    Content type: Research Published on:

  28. Platelet-rich plasma (PRP) is widely used to treat tendon injuries in clinics. These PRP preparations often contain white blood cells or leukocytes, and the precise cellular effects of leukocyte-rich PRP (L-PR...

    Authors: Yiqin Zhou, Jianying Zhang, Haishan Wu, MaCalus V. Hogan and James H-C. Wang
    Citation: Stem Cell Research & Therapy 2015 6:173
    Content type: Research Published on:

  29. Activation of endogenous stem cell mobilization can contribute to myocardial regeneration after ischemic injury. This study aimed to evaluate the possible role of Avemar or Echinacea extracts in inducing mobiliza...

    Authors: Maha Abdelmonem, Samar H. Kassem, Hala Gabr, Amira A. Shaheen and Tarek Aboushousha
    Citation: Stem Cell Research & Therapy 2015 6:172
    Content type: Research Published on:

  31. Liver transplantation is a gold standard treatment for intractable liver diseases. Because of the shortage of donor organs, alternative therapies have been required. Due to their potential to differentiate int...

    Authors: Takayoshi Yamaza, Fatima Safira Alatas, Ratih Yuniartha, Haruyoshi Yamaza, Junko K. Fujiyoshi, Yusuke Yanagi, Koichiro Yoshimaru, Makoto Hayashida, Toshiharu Matsuura, Reona Aijima, Kenji Ihara, Shouichi Ohga, Songtao Shi, Kazuaki Nonaka and Tomoaki Taguchi
    Citation: Stem Cell Research & Therapy 2015 6:171
    Content type: Research Published on:

  32. Due to their immunomodulatory properties, mesenchymal stromal cells (MSCs) have been used for auto-immune disease treatment. Crohn disease (CD) and ulcerative colitis are two major inflammatory bowel diseases ...

    Authors: Dorian Forte, Marilena Ciciarello, Maria Chiara Valerii, Luigia De Fazio, Elena Cavazza, Rosaria Giordano, Valentina Parazzi, Lorenza Lazzari, Silvio Laureti, Fernando Rizzello, Michele Cavo, Antonio Curti, Roberto M. Lemoli, Enzo Spisni and Lucia Catani
    Citation: Stem Cell Research & Therapy 2015 6:170
    Content type: Research Published on:

  33. Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and multilineage differentiation. Their multipotential capacity and immunomodulatory properties have led to an increasing interest in...

    Authors: Carmen Muñiz, Cristina Teodosio, Andrea Mayado, Ana Teresa Amaral, Sergio Matarraz, Paloma Bárcena, Maria Luz Sanchez, Iván Alvarez-Twose, María Diez-Campelo, Andrés C. García-Montero, Juan F. Blanco, Maria Consuelo Del Cañizo, Javier del Pino Montes and Alberto Orfao
    Citation: Stem Cell Research & Therapy 2015 6:169
    Content type: Research Published on:

  34. We have recently found that miR-17 is necessary in the cell-extrinsic control of cord blood (CB) CD34+ cell function. Here, we demonstrated that the proper level of miR-17 is also necessary in the cell-intrinsic ...

    Authors: Yuxia Yang, Saifeng Wang, Zhenchuan Miao, Wei Ma, Yanju Zhang, Li Su, Mengyu Hu, Junhua Zou, Yuxin Yin and Jianyuan Luo
    Citation: Stem Cell Research & Therapy 2015 6:168
    Content type: Research Published on:

  35. Bone marrow-derived mesenchymal stromal cells (MSCs) have been intensely studied for the purpose of developing solutions for clinical tissue engineering. Autologous MSCs can potentially be used to replace tiss...

    Authors: Eeva Castrén, Tarvo Sillat, Sofia Oja, Ariel Noro, Anita Laitinen, Yrjö T Konttinen, Petri Lehenkari, Mika Hukkanen and Matti Korhonen
    Citation: Stem Cell Research & Therapy 2015 6:167
    Content type: Research Published on:

  36. Tumor necrosis factor alpha (TNFα) plays a physiological role in controlling synaptic transmission and plasticity in the healthy central nervous system by modulating glutamate receptor trafficking to the plasm...

    Authors: Raffaella Morini, Elsa Ghirardini, Erica Butti, Claudia Verderio, Gianvito Martino and Michela Matteoli
    Citation: Stem Cell Research & Therapy 2015 6:166
    Content type: Research Published on:

  37. Studies have proposed that mesenchymal stem cells (MSCs) improve the hematopoietic engraftment in allogeneic or xenogeneic transplants and this is probably due to the MSCs’ immunosuppressive properties. Our st...

    Authors: María Fernández-García, Rosa M. Yañez, Rebeca Sánchez-Domínguez, Miriam Hernando-Rodriguez, Miguel Peces-Barba, Guadalupe Herrera, Jose E. O’Connor, José C. Segovia, Juan A. Bueren and María L. Lamana
    Citation: Stem Cell Research & Therapy 2015 6:165
    Content type: Research Published on:

  38. The in vivo therapeutic effect of mesenchymal stromal cells (MSCs) is currently believed to be tightly linked to their paracrine secretion ability. However, insufficient or imprecise cell delivery, low cell su...

    Authors: Xin Lin, Mikella Robinson, Tye Petrie, Veronica Spandler, W. Douglas Boyd and Claus Svane Sondergaard
    Citation: Stem Cell Research & Therapy 2015 6:164
    Content type: Research Published on:

  39. In this study, we planned to assess if adult stem cell-based suicide gene therapy can efficiently eliminate glioblastoma cells in vivo. We investigated the therapeutic potential of mouse Oct4− bone marrow multipo...

    Authors: Cindy Leten, Jesse Trekker, Tom Struys, Tom Dresselaers, Rik Gijsbers, Greetje Vande Velde, Ivo Lambrichts, Annemie Van Der Linden, Catherine M. Verfaillie and Uwe Himmelreich
    Citation: Stem Cell Research & Therapy 2015 6:163
    Content type: Research Published on:

  40. Dental pulp stem cells (DPSCs) are mesenchymal stem cells located in dental pulp and are thought to be a potential source for cell therapy since DPSCs can be easily obtained from teeth extracted for orthodonti...

    Authors: Masaki Hata, Maiko Omi, Yasuko Kobayashi, Nobuhisa Nakamura, Takahiro Tosaki, Megumi Miyabe, Norinaga Kojima, Katsutoshi Kubo, Shogo Ozawa, Hatsuhiko Maeda, Yoshinobu Tanaka, Tatsuaki Matsubara and Keiko Naruse
    Citation: Stem Cell Research & Therapy 2015 6:162
    Content type: Research Published on:

  41. Bone abnormalities, one of the primary manifestations of Menkes disease (MD), include a weakened bone matrix and low mineral density. However, the molecular and cellular mechanisms underlying these bone defect...

    Authors: Dongkyu Kim, Jieun Choi, Kyu-Min Han, Beom Hee Lee, Jin-Ho Choi, Han-Wook Yoo and Yong-Mahn Han
    Citation: Stem Cell Research & Therapy 2015 6:160
    Content type: Research Published on:

  42. Growing evidence suggests that transcriptional regulators and secreted RNA molecules encapsulated within membrane vesicles modify the phenotype of target cells. Membrane vesicles, actively released by cells, r...

    Authors: Peter J. Quesenberry, Jason Aliotta, Maria Chiara Deregibus and Giovanni Camussi
    Citation: Stem Cell Research & Therapy 2015 6:153
    Content type: Review Published on:

  43. Despite multimodal regimens and diverse treatment options alleviating disease symptoms, morbidity and mortality associated with advanced ischemic heart failure remain high. Recently, technological innovation h...

    Authors: Marko Banovic, Zlatibor Loncar, Atta Behfar, Marc Vanderheyden, Branko Beleslin, Andreas Zeiher, Marco Metra, Andre Terzic and Jozef Bartunek
    Citation: Stem Cell Research & Therapy 2015 6:159
    Content type: Review Published on:

  44. Zellweger spectrum disorder (PBD-ZSD) is a disease continuum caused by mutations in a subset of PEX genes required for normal peroxisome assembly and function. They highlight the importance of peroxisomes in the ...

    Authors: Xiao-Ming Wang, Wing Yan Yik, Peilin Zhang, Wange Lu, Ning Huang, Bo Ram Kim, Darryl Shibata, Madison Zitting, Robert H. Chow, Ann B. Moser, Steven J. Steinberg and Joseph G. Hacia
    Citation: Stem Cell Research & Therapy 2015 6:158
    Content type: Research Published on:

  45. Cancers are believed to adapt to continual changes in glucose and oxygen availability by relying almost exclusively on glycolytic metabolism for energy (i.e. the Warburg effect). The process by which breast ca...

    Authors: Nicole Gordon, Amy M. Skinner, Rodney F. Pommier, Robynn V. Schillace, Steven O’Neill, Jennifer L. Peckham, Patrick Muller, Mary E. Condron, Cory Donovan, Arpana Naik, Juliana Hansen and SuEllen J. Pommier
    Citation: Stem Cell Research & Therapy 2015 6:157
    Content type: Research Published on:

  46. Duchenne muscular dystrophy (DMD), caused by a lack of the functional structural protein dystrophin, leads to severe muscle degeneration where the patients are typically wheelchair-bound and die in their mid-t...

    Authors: Alessandra Pisciotta, Massimo Riccio, Gianluca Carnevale, Aiping Lu, Sara De Biasi, Lara Gibellini, Giovanni B. La Sala, Giacomo Bruzzesi, Adriano Ferrari, Johnny Huard and Anto De Pol
    Citation: Stem Cell Research & Therapy 2015 6:156
    Content type: Research Published on:

  47. In the context of drug delivery, mesenchymal stromal cells (MSCs) from bone marrow and adipose tissue have emerged as interesting candidates due to their homing abilities and capacity to carry toxic loads, whi...

    Authors: Arianna Bonomi, Antonietta Silini, Elsa Vertua, Patrizia Bonassi Signoroni, Valentina Coccè, Loredana Cavicchini, Francesca Sisto, Giulio Alessandri, Augusto Pessina and Ornella Parolini
    Citation: Stem Cell Research & Therapy 2015 6:155
    Content type: Research Published on:

  48. Cell-based therapy was a promising treatment method for disc degenerative diseases. Wharton’s jelly cell (WJC) has been explored to cure various human diseases, while it still remains unknown about this MSC fo...

    Authors: Yan Zhang, Hui Tao, Tao Gu, Mingyue Zhou, Zhiwei Jia, Gangqiang Jiang, Chun Chen, Zhihua Han, Cheng Xu, Deli Wang, Qing He and Dike Ruan
    Citation: Stem Cell Research & Therapy 2015 6:154
    Content type: Research Published on:

  49. Premature ovarian failure and insufficiency are significant long-term side-effects of chemotherapy for female cancer patients. Recently, stem cell transplantation has been identified as a promising treatment f...

    Authors: Qiuwan Zhang, Minhua Xu, Xiaofen Yao, Ting Li, Qian Wang and Dongmei Lai
    Citation: Stem Cell Research & Therapy 2015 6:152
    Content type: Research Published on:

  50. Conventionally cultured mouse bone marrow mesenchymal stromal cells (mBM-MSC) are a heterogeneous population that often initially contain contaminating haematopoietic cells. Variability in isolation methods, c...

    Authors: Claas Baustian, Shirley Hanley and Rhodri Ceredig
    Citation: Stem Cell Research & Therapy 2015 6:151
    Content type: Research Published on:
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