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  1. Cell-based therapy was a promising treatment method for disc degenerative diseases. Wharton’s jelly cell (WJC) has been explored to cure various human diseases, while it still remains unknown about this MSC fo...

    Authors: Yan Zhang, Hui Tao, Tao Gu, Mingyue Zhou, Zhiwei Jia, Gangqiang Jiang, Chun Chen, Zhihua Han, Cheng Xu, Deli Wang, Qing He and Dike Ruan
    Citation: Stem Cell Research & Therapy 2015 6:154
    Content type: Research Published on:

  2. Premature ovarian failure and insufficiency are significant long-term side-effects of chemotherapy for female cancer patients. Recently, stem cell transplantation has been identified as a promising treatment f...

    Authors: Qiuwan Zhang, Minhua Xu, Xiaofen Yao, Ting Li, Qian Wang and Dongmei Lai
    Citation: Stem Cell Research & Therapy 2015 6:152
    Content type: Research Published on:

  3. Conventionally cultured mouse bone marrow mesenchymal stromal cells (mBM-MSC) are a heterogeneous population that often initially contain contaminating haematopoietic cells. Variability in isolation methods, c...

    Authors: Claas Baustian, Shirley Hanley and Rhodri Ceredig
    Citation: Stem Cell Research & Therapy 2015 6:151
    Content type: Research Published on:

  4. Multipotent stromal cells (MSCs) are among the key candidates in regenerative medicine. However variety of MSC sources and general heterogeneity lead to controversial data in functional characterization. Furth...

    Authors: Olena Pogozhykh, Denys Pogozhykh, Anna-Lena Neehus, Andrea Hoffmann, Rainer Blasczyk and Thomas Müller
    Citation: Stem Cell Research & Therapy 2015 6:150
    Content type: Research Published on:

  5. Conditionally immortalised human neural progenitor cells (hNPCs) represent a robust source of native neural cells to investigate physiological mechanisms in both health and disease. However, in order to recogn...

    Authors: Greg W. Anderson, P. J. Michael Deans, Ruth D T Taylor, Pooja Raval, Ding Chen, Harrison Lowder, Srishti Murkerji, Laura C. Andreae, Brenda P. Williams and Deepak P. Srivastava
    Citation: Stem Cell Research & Therapy 2015 6:149
    Content type: Research Published on:

  6. Doxorubicin (DOX) is a well-known anticancer drug. However its clinical use has been limited due to cardiotoxic effects. One of the major concerns with DOX therapy is its toxicity in patients who are frail, pa...

    Authors: Hania Ibrahim Ammar, Glen Lester Sequiera, Mira B. Nashed, Rasha I. Ammar, Hala M. Gabr, Hany E. Elsayed, Niketa Sareen, Ejlal Abu-El Rub, Maha B. Zickri and Sanjiv Dhingra
    Citation: Stem Cell Research & Therapy 2015 6:148
    Content type: Research Published on:

  7. Mesenchymal stem cells (MSCs) have therapeutic potential for the repair of myocardial injury. The efficacy of MSC therapy for myocardial regeneration mainly depends on the survival of cells after transplantati...

    Authors: Onju Ham, Se-Yeon Lee, Chang Youn Lee, Jun-Hee Park, Jiyun Lee, Hyang-Hee Seo, Min-Ji Cha, Eunhyun Choi, Soonhag Kim and Ki-Chul Hwang
    Citation: Stem Cell Research & Therapy 2015 6:147
    Content type: Research Published on:

  8. Over the last two decades, a new therapeutic paradigm has emerged which has changed the way debilitating diseases may be treated in the future. Instead of using small-molecule drugs and devices to ameliorate t...

    Authors: Timothy O’Brien, Michael Creane, Anthony J. Windebank, Andre Terzic and Allan B. Dietz
    Citation: Stem Cell Research & Therapy 2015 6:146
    Content type: Review Published on:

  9. Redundant collagen deposition at sites of healing dermal wounds results in hypertrophic scars. Adipose-derived stem cells (ADSCs) exhibit promise in a variety of anti-fibrosis applications by attenuating colla...

    Authors: Qi Zhang, Li-Na Liu, Qi Yong, Jing-Cheng Deng and Wei-Gang Cao
    Citation: Stem Cell Research & Therapy 2015 6:145
    Content type: Research Published on:

  10. Previously, we established a simple method for deriving mesenchymal stem cells (MSCs) from human induced pluripotent stem cells (iPSC-MSCs). These iPSC-MSCs were capable of forming osteogenic structures in sca...

    Authors: Ran Kang, Yan Zhou, Shuang Tan, Guangqian Zhou, Lars Aagaard, Lin Xie, Cody Bünger, Lars Bolund and Yonglun Luo
    Citation: Stem Cell Research & Therapy 2015 6:144
    Content type: Research Published on:

  12. An effective immune response to severe bacterial infections requires a robust production of the innate immunity cells from hematopoietic stem and progenitor cells (HSPCs) in a process called emergency myelopoi...

    Authors: Tomasz Skirecki, Jerzy Kawiak, Eugeniusz Machaj, Zygmunt Pojda, Danuta Wasilewska, Jarosław Czubak and Grażyna Hoser
    Citation: Stem Cell Research & Therapy 2015 6:142
    Content type: Research Published on:

  14. To this end human MSCs were isolated from adipose tissue and the MSC:CD4+ T-cell suppression was assessed in a co-culture system. In summary, this study demonstrates that advanced age, atherosclerosis and type 2 ...

    Authors: Ozge Kizilay Mancini, Dominique Shum-Tim, Ursula Stochaj, José A. Correa and Inés Colmegna
    Citation: Stem Cell Research & Therapy 2015 6:140
    Content type: Short report Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2017 8:35

  15. Endothelial colony-forming cells (ECFCs) significantly improve tissue repair by providing regeneration potential within injured cardiovascular tissue. However, ECFC transplantation into ischemic tissue exhibit...

    Authors: Sang Hun Lee, Jun Hee Lee, Yong-Seok Han, Jung Min Ryu, Yeo Min Yoon and Ho Jae Han
    Citation: Stem Cell Research & Therapy 2015 6:139
    Content type: Research Published on:

  16. Therapeutic angiogenesis by transplantation of autologous/allogeneic adipose-derived stem cells (ADSCs) is a potential approach for severe ischemic diseases. However, poor viability, adhesion, migration and di...

    Authors: Jinbao Qin, Fukang Yuan, Zhiyou Peng, Kaichuang Ye, Xinrui Yang, Lijia Huang, Mier Jiang and Xinwu Lu
    Citation: Stem Cell Research & Therapy 2015 6:138
    Content type: Research Published on:

  17. Crohn’s disease (CD) is a disabling chronic enteropathy sustained by a harmful T-cell response toward antigens of the gut microbiota in genetically susceptible subjects. Growing evidence highlights the safety ...

    Authors: Rachele Ciccocioppo, Giuseppina C. Cangemi, Peter Kruzliak, Alessandra Gallia, Elena Betti, Carla Badulli, Miryam Martinetti, Marila Cervio, Alessandro Pecci, Valeria Bozzi, Paolo Dionigi, Livia Visai, Antonella Gurrado, Costanza Alvisi, Cristina Picone, Manuela Monti…
    Citation: Stem Cell Research & Therapy 2015 6:137
    Content type: Research Published on:

  18. Bone marrow-derived stromal cells (BMSCs), also known as mesenchymal stem cells, are the focus of intensive efforts worldwide to elucidate their function and biology. Despite the importance of BMSC migration f...

    Authors: Caroline M. Ryan, James A. L. Brown, Emer Bourke, Áine M. Prendergast, Claire Kavanagh, Zhonglin Liu, Peter Owens, Georgina Shaw, Walter Kolch, Timothy O’Brien and Frank P. Barry
    Citation: Stem Cell Research & Therapy 2015 6:136
    Content type: Research Published on:

  19. Tumor microenvironment conferred by stromal (mesenchymal) stem cells (MSCs) plays a key role in tumor development, progression, and response to therapy. Defining the role of MSCs in tumorigenesis is crucial fo...

    Authors: Mashael Al-toub, Radhakrishnan Vishnubalaji, Rimi Hamam, Moustapha Kassem, Abdullah Aldahmash and Nehad M. Alajez
    Citation: Stem Cell Research & Therapy 2015 6:135
    Content type: Research Published on:

  20. The aim of our study is to identify the contribution of hematopoietic-derived cells to burn-wound healing in a non-severe injury. There are many conflicting reports of the contribution of bone marrow-derived c...

    Authors: Suzanne Rea, Andrew Stevenson, Natalie L. Giles, Fiona M. Wood and Mark W. Fear
    Citation: Stem Cell Research & Therapy 2015 6:134
    Content type: Research Published on:

  21. The use of human umbilical cord Wharton Jelly-derived mesenchymal stem cells (hWJ-MSCs) has been considered a new potential source for future safe applications in regenerative medicine. Indeed, the application...

    Authors: Fábio G. Teixeira, Krishna M. Panchalingam, Sandra Isabel Anjo, Bruno Manadas, Ricardo Pereira, Nuno Sousa, António J. Salgado and Leo A. Behie
    Citation: Stem Cell Research & Therapy 2015 6:133
    Content type: Research Published on:

  22. Histone H3 lysine 27 trimethylation (H3K27me3) and H3 lysine 36 trimethylation (H3K36me3) are important epigenetic modifications correlated with transcription repression and activation, respectively. These two...

    Authors: Hailei Mao, Gang Han, Longyong Xu, Duming Zhu, Hanqing Lin, Xiongwen Cao, Yi Yu and Charlie Degui Chen
    Citation: Stem Cell Research & Therapy 2015 6:132
    Content type: Research Published on:

  23. Stem cells have been evaluated as a potential therapeutic approach for several neurological disorders of the central and peripheral nervous system as well as for traumatic brain and spinal cord injury. Current...

    Authors: Maria-Adelaide Micci, Debbie R. Boone, Margaret A. Parsley, Jingna Wei, Igor Patrikeev, Massoud Motamedi and Helen L. Hellmich
    Citation: Stem Cell Research & Therapy 2015 6:131
    Content type: Research Published on:

  25. Cell replacement therapy may be considered as an alternate approach to provide therapeutic dose of plasma factor VIII (FVIII) in patients with hemophilia A (HA). However, immune rejection limits the use of all...

    Authors: Veena Kochat, Sumod Kanjirakkuzhiyil, Prakash Baligar, Perumal Nagarajan and Asok Mukhopadhyay
    Citation: Stem Cell Research & Therapy 2015 6:129
    Content type: Research Published on:

  26. Peripheral nerves may fail to regenerate across tube implants because these lack the microarchitecture of native nerves. Bone marrow mesenchymal stem cells (MSC) secrete soluble factors that improve the regene...

    Authors: A. Carrier-Ruiz, F. Evaristo-Mendonça, R. Mendez-Otero and V. T. Ribeiro-Resende
    Citation: Stem Cell Research & Therapy 2015 6:128
    Content type: Research Published on:

  27. In light of pioneering findings in the 1980s and an estimation of more than 130 million global annual births, umbilical cord blood (UCB) is considered to be the most plentiful reservoir of cells and to have re...

    Authors: Santiago Roura, Josep-Maria Pujal, Carolina Gálvez-Montón and Antoni Bayes-Genis
    Citation: Stem Cell Research & Therapy 2015 6:123
    Content type: Review Published on:

  28. Administration of mesenchymal stem cells (MSCs) represents a promising treatment option for patients suffering from immunological and degenerative disorders. Accumulating evidence indicates that the healing ef...

    Authors: Serena Rubina Baglio, Koos Rooijers, Danijela Koppers-Lalic, Frederik J. Verweij, M Pérez Lanzón, Nicoletta Zini, Benno Naaijkens, Francesca Perut, Hans W. M. Niessen, Nicola Baldini and D. Michiel Pegtel
    Citation: Stem Cell Research & Therapy 2015 6:127
    Content type: Research Published on:

  29. Autologous blood-derived biologicals, including autologous conditioned serum (ACS), are frequently used to treat tendinopathies in horses despite limited evidence for their efficacy. The purpose of this study ...

    Authors: Florian Geburek, Maren Lietzau, Andreas Beineke, Karl Rohn and Peter M. Stadler
    Citation: Stem Cell Research & Therapy 2015 6:126
    Content type: Research Published on:

  30. Induced pluripotent stem cells (iPSCs) have emerged as a promising cell source for immune-compatible cell therapy. Although a variety of somatic cells have been tried for iPSC generation, it is still of great ...

    Authors: Jinsoo Oh, Kang-In Lee, Hyeong-Taek Kim, Youngsang You, Do Heum Yoon, Ki Yeong Song, Eunji Cheong, Yoon Ha and Dong-Youn Hwang
    Citation: Stem Cell Research & Therapy 2015 6:125
    Content type: Research Published on:

  31. Chemotherapy has made an essential contribution to cancer treatment in recent decades despite its adverse effects. As cancer survivors have increased, concern about ex-patient lifespan has become more importan...

    Authors: Fernando Ezquer, Jaime Gutiérrez, Marcelo Ezquer, Christian Caglevic, Helio C Salgado and Sebastián D Calligaris
    Citation: Stem Cell Research & Therapy 2015 6:116
    Content type: Review Published on:

  32. Surface modification of titanium (Ti) implants promotes bone formation and shortens the osseointegration period. The aim of this study was to promote bone regeneration and stability around implants using atmos...

    Authors: Masahiro Omori, Shuhei Tsuchiya, Kenji Hara, Kensuke Kuroda, Hideharu Hibi, Masazumi Okido and Minoru Ueda
    Citation: Stem Cell Research & Therapy 2015 6:124
    Content type: Research Published on:

  33. The prospect of therapeutic applications of the induced pluripotent stem cells (iPSCs) is based on their ability to generate virtually any cell type present in human body. Generation of iPSCs from somatic cell...

    Authors: Anna M. Drozd, Maciej P. Walczak, Sylwester Piaskowski, Ewelina Stoczynska-Fidelus, Piotr Rieske and Dawid P. Grzela
    Citation: Stem Cell Research & Therapy 2015 6:122
    Content type: Research Published on:

  34. Despite its high incidence, nerve fiber (axon and myelin) damage after cerebral infarct has not yet been extensively investigated. The aim of this study was to investigate white matter repair after adipose-der...

    Authors: Laura Otero-Ortega, María Gutiérrez-Fernández, Jaime Ramos-Cejudo, Berta Rodríguez-Frutos, Blanca Fuentes, Tomás Sobrino, Teresa Navarro Hernanz, Francisco Campos, Juan Antonio López, Sebastián Cerdán, Jesús Vázquez and Exuperio Díez-Tejedor
    Citation: Stem Cell Research & Therapy 2015 6:121
    Content type: Research Published on:

  35. Wnt and Notch signaling pathways are critically involved in relative cell fate decisions within the development of cutaneous tissues. Moreover, several studies identified the above two pathways as having a sig...

    Authors: Yan Shi, Bin Shu, Ronghua Yang, Yingbin Xu, Bangrong Xing, Jian Liu, Lei Chen, Shaohai Qi, Xusheng Liu, Peng Wang, Jinming Tang and Julin Xie
    Citation: Stem Cell Research & Therapy 2015 6:120
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2015 6:254

  36. Nuclear accumulation of a mutant form of the nuclear protein Lamin-A, called Progerin (PG) or Lamin AΔ50, occurs in Hutchinson-Gilford Progeria Syndrome (HGPS) or Progeria, an accelerated aging disease. One of...

    Authors: Jesús Mateos, Arancha Landeira-Abia, Juan Antonio Fafián-Labora, Pablo Fernández-Pernas, Iván Lesende-Rodríguez, Patricia Fernández-Puente, Mercedes Fernández-Moreno, Aitor Delmiro, Miguel A. Martín, Francisco J. Blanco and María C. Arufe
    Citation: Stem Cell Research & Therapy 2015 6:119
    Content type: Research Published on:

  37. The worldwide shortage of donor livers has prompted the search for alternative cell therapies. Previous data from our laboratory proved a supportive role for stem cell therapy in the treatment of end-stage liv...

    Authors: Abdel-Rahman N. Zekri, Hosny Salama, Eman Medhat, Sherief Musa, Hanan Abdel-Haleem, Ola S. Ahmed, Hanan Abdel Hafez Khedr, Mai M. Lotfy, Khaled S. Zachariah and Abeer A. Bahnassy
    Citation: Stem Cell Research & Therapy 2015 6:118
    Content type: Research Published on:

  39. The increasing interest in 99m-technetium (99mTc)-labeled stem cells encouraged us to study the 99mTc binding sites in stem cell compartments.

    Authors: Grazielle Dias Suhett, Sergio Augusto Lopes de Souza, Adriana Bastos Carvalho, Rachel de Pinho Rachid, Narcisa Leal da Cunha-E-Silva, Antonio Carlos Campos de Carvalho, Lea Mirian Barbosa da Fonseca, Regina Coeli dos Santos Goldenberg and Bianca Gutfilen
    Citation: Stem Cell Research & Therapy 2015 6:115
    Content type: Research Published on:

  40. The bursa subacromialis (BS) provides the gliding mechanism of the shoulder and regenerates itself after surgical removal. Therefore, we explored the presence of mesenchymal stem cells (MSCs) within the human ...

    Authors: Andre F. Steinert, Manuela Kunz, Patrick Prager, Sascha Göbel, Ludger Klein-Hitpass, Regina Ebert, Ulrich Nöth, Franz Jakob and Frank Gohlke
    Citation: Stem Cell Research & Therapy 2015 6:114
    Content type: Research Published on:

  42. Irreversible end-stage organ failure represents one of the leading causes of death, and organ transplantation is currently the only curative solution. Donor organ shortage and adverse effects of immunosuppress...

    Authors: Andrea Peloso, Abritee Dhal, Joao P Zambon, Peng Li, Giuseppe Orlando, Anthony Atala and Shay Soker
    Citation: Stem Cell Research & Therapy 2015 6:107
    Content type: Review Published on:

  43. Testicular torsion is a urological emergency and infertility is a common complication due to ischemic injury. Surgical reduction and orchiopexy is indicated, but to date there is no effective method for restor...

    Authors: Chi-Hao Hsiao, Andrea Tung-Qian Ji, Chih-Cheng Chang, Chien-Jui Cheng, Liang-Ming Lee and Jennifer Hui-Chun Ho
    Citation: Stem Cell Research & Therapy 2015 6:113
    Content type: Research Published on:

  44. Most studies on intracoronary bone marrow mononuclear cell transplantation for acute myocardial infarction involve treatment 3–7 days after primary percutaneous coronary intervention (PCI); however, the optima...

    Authors: Rongchong Huang, Kang Yao, Aijun Sun, Juying Qian, Lei Ge, Yiqi Zhang, Yuhong Niu, Keqiang Wang, Yunzeng Zou and Junbo Ge
    Citation: Stem Cell Research & Therapy 2015 6:112
    Content type: Research Published on:

  45. The release of trophic factors from mesenchymal stem cells (MSCs) is critical for tissue regeneration. A systematic investigation of the regenerative potential of trophic factors from different MSCs, however, ...

    Authors: Y Hayashi, M Murakami, R Kawamura, R Ishizaka, O Fukuta and M Nakashima
    Citation: Stem Cell Research & Therapy 2015 6:111
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:86

  46. Stem cell therapy with bone marrow-derived mononuclear cells (BMMCs) is an option for improving joint function in osteonecrosis of the femoral head (ONFH). Bone marrow-derived mesenchymal stromal cell (MSC) nu...

    Authors: Gildasio Cerqueira Daltro, Vitor Fortuna, Eliane Silva de Souza, Marcela Miranda Salles, Ana Claudia Carreira, Roberto Meyer, Songeli Menezes Freire and Radovan Borojevic
    Citation: Stem Cell Research & Therapy 2015 6:110
    Content type: Research Published on:

  48. Engineered bioimplants for cardiac repair require functional vascularization and innervation for proper integration with the surrounding myocardium. The aim of this work was to study nerve sprouting and neovas...

    Authors: Carolina Gálvez-Montón, M. Teresa Fernandez-Figueras, Mercè Martí, Carolina Soler-Botija, Santiago Roura, Isaac Perea-Gil, Cristina Prat-Vidal, Aida Llucià-Valldeperas, Ángel Raya and Antoni Bayes-Genis
    Citation: Stem Cell Research & Therapy 2015 6:108
    Content type: Short report Published on:

  49. Severe spinal cord injury often causes temporary or permanent damages in strength, sensation, or autonomic functions below the site of the injury. So far, there is still no effective treatment for spinal cord ...

    Authors: Xue-Cheng Qiu, Hui Jin, Rong-Yi Zhang, Ying Ding, Xiang Zeng, Bi-Qin Lai, Eng-Ang Ling, Jin-Lang Wu and Yuan-Shan Zeng
    Citation: Stem Cell Research & Therapy 2015 6:105
    Content type: Research Published on:

  50. Secondary osteoporosis is common in systemic lupus erythematosus and leads to a reduction in quality of life due to fragility fractures, even in patients with improvement of the primary disorder. Systemic tran...

    Authors: Lan Ma, Reona Aijima, Yoshihiro Hoshino, Haruyoshi Yamaza, Erika Tomoda, Yosuke Tanaka, Soichiro Sonoda, Guangtai Song, Wei Zhao, Kazuaki Nonaka, Songtao Shi and Takayoshi Yamaza
    Citation: Stem Cell Research & Therapy 2015 6:104
    Content type: Research Published on:
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