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  1. The female reproductive tract produces hormones for reproductive function and cardiovascular, bone and sexual health; the tract supplies a finite number of gametes, and it supports fetal development. Diseases ...

    Authors: Monica M Laronda, Joanna E Burdette, J Julie Kim and Teresa K Woodruff
    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S13

    This article is part of a Supplement: Volume 4 Supplement 1

  2. The vast majority of cancer mortalities result from distant metastases. The metastatic microenvironment provides unique protection to ectopic tumors as the primary tumors often respond to specific agents. Alth...

    Authors: Sarah E Wheeler, Jeffrey T Borenstein, Amanda M Clark, Mohammad R Ebrahimkhani, Ira J Fox, Linda Griffith, Walker Inman, Douglas Lauffenburger, Transon Nguyen, Venkateswaran C Pillai, Rachelle Prantil-Baun, Donna B Stolz, Donald Taylor, Theresa Ulrich, Raman Venkataramanan, Alan Wells…
    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S11

    This article is part of a Supplement: Volume 4 Supplement 1

  3. A multiorgan, functional, human in vitro assay system or 'Body-on-a-Chip' would be of tremendous benefit to the drug discovery and toxicology industries, as well as providing a more biologically accurate model fo...

    Authors: Alec ST Smith, Christopher J Long, Bonnie J Berry, Christopher McAleer, Maria Stancescu, Peter Molnar, Paula G Miller, Mandy B Esch, Jean-Matthieu Prot, James J Hickman and Michael L Shuler
    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S9

    This article is part of a Supplement: Volume 4 Supplement 1

  4. Detailed studies of lung pathology in patients during the course of development of acute lung injury or respiratory distress are limited, and in the past information related to lung-specific responses has been...

    Authors: Joan E Nichols, Jean A Niles, Stephanie P Vega and Joaquin Cortiella
    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S7

    This article is part of a Supplement: Volume 4 Supplement 1

  5. Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointesti...

    Authors: Kira G Hartman, James D Bortner Jr, Gary W Falk, Jian Yu, Martín G Martín, Anil K Rustgi and John P Lynch
    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S5

    This article is part of a Supplement: Volume 4 Supplement 1

  6. Researchers need an available and easy-to-use model of the human intestine to better understand human intestinal physiology and pathophysiology of diseases, and to offer an enhanced platform for developing dru...

    Authors: Olga Kovbasnjuk, Nicholas C Zachos, Julie In, Jennifer Foulke-Abel, Khalil Ettayebi, Joseph M Hyser, James R Broughman, Xi-Lei Zeng, Sabine Middendorp, Hugo R de Jonge, Mary K Estes and Mark Donowitz
    Citation: Stem Cell Research & Therapy 2013 4(Suppl 1):S3

    This article is part of a Supplement: Volume 4 Supplement 1

  7. Retrograde coronary venous infusion is a promising delivery method for cellular cardiomyoplasty. Poor cell retention is the major obstacle to the establishment of this method as the preferred route for cell de...

    Authors: Zheyong Huang, Yunli Shen, Aijun Sun, Gangyong Huang, Hongmin Zhu, Bingqing Huang, Jianfeng Xu, Yanan Song, Ning Pei, Jing Ma, Xiangdong Yang, Yunzeng Zou, Juying Qian and Junbo Ge
    Citation: Stem Cell Research & Therapy 2013 4:149
  8. Adipose-derived stem cells (ASCs) are progenitor cells used in bone tissue engineering and regenerative medicine. Despite subcutaneous adipose tissue being more abundant, the buccal fat pad (BFP) is easily acc...

    Authors: Stefania Niada, Lorena Maria Ferreira, Elena Arrigoni, Alessandro Addis, Marino Campagnol, Eugenio Broccaioli and Anna Teresa Brini
    Citation: Stem Cell Research & Therapy 2013 4:148
  9. Human amniotic fluid stem (hAFS) cells have been shown to differentiate into multiple lineages, including myoblasts. However, molecular mechanisms underlying the myogenic differentiation of hAFS cells and thei...

    Authors: Ju Ang Kim, Yun Hee Shon, Jeong Ok Lim, James J Yoo, Hong-In Shin and Eui Kyun Park
    Citation: Stem Cell Research & Therapy 2013 4:147
  10. The existence of breast cancer stem-like cells (BCSCs) has profound implications for cancer prevention. Genistein, a predominant isoflavone found in soy products, has multiple robust anti-tumor effects in vari...

    Authors: Panhong Fan, Shujun Fan, Huan Wang, Jun Mao, Yu Shi, Mohammed M Ibrahim, Wei Ma, Xiaotang Yu, Zhenhuan Hou, Bo Wang and Lianhong Li
    Citation: Stem Cell Research & Therapy 2013 4:146
  11. Embryonic stem (ES) cells are considered a potentially advantageous source of hepatocytes for both transplantation and the development of bioartificial livers. However, the efficient large-scale generation of ...

    Authors: Shichang Zhang, Yunping Zhang, Li Chen, Tao Liu, Yangxin Li, Yingjie Wang and Yongjian Geng
    Citation: Stem Cell Research & Therapy 2013 4:145
  12. Multiple myeloma is a common hematological malignancy that leads to the occurrence of bone lesions. The combination of traditional cytotoxic and novel agents is usually taken to treat multiple myeloma-related ...

    Authors: Jinhua Yu and Yao Li
    Citation: Stem Cell Research & Therapy 2013 4:144
  13. Acute respiratory distress syndrome (ARDS) is one of the devastating sequelae of sepsis, and so far no specific promising pharmacotherapies have been proven to decrease mortality from it. Stem cell therapy is ...

    Authors: Paolo Pelosi and Yuda Sutherasan
    Citation: Stem Cell Research & Therapy 2013 4:143
  14. With the shortage of donor organs for islet transplantation, insulin-producing cells have been generated from different types of stem cell. Human fetal pancreatic stem cells have a better self-renewal capacity...

    Authors: Wen-Jian Zhang, Shi-Qing Xu, Han-Qing Cai, Xiu-Li Men, Zai Wang, Hua Lin, Li Chen, Yong-Wei Jiang, Hong-Lin Liu, Cheng-Hui Li, Wei-Guo Sui, Hong-Kui Deng and Jin-Ning Lou
    Citation: Stem Cell Research & Therapy 2013 4:141
  15. Cell therapy using mesenchymal stromal cells (MSCs) is a promising new avenue of treatment for critical limb ischemia (CLI). Preclinical studies have suggested that MSCs enhance neovascularization in ischemic ...

    Authors: Hendrik Gremmels, Joost O Fledderus, Martin Teraa and Marianne C Verhaar
    Citation: Stem Cell Research & Therapy 2013 4:140
  16. Impaction allograft with cement is a common technique used in revision hip surgeries for the last 20 years. However, its clinical results are inconsistent. Recent studies have shown that mesenchymal stem cells...

    Authors: Yannis Reissis, Elena García-Gareta, Michelle Korda, Gordon W Blunn and Jia Hua
    Citation: Stem Cell Research & Therapy 2013 4:139
  17. Primordial germ cells (PGCs) are the major population of cells in the developing bilateral embryonic gonads. Little is known about the cellular responses of PGCs after treatment with toxic chemicals such as bu...

    Authors: Hyung Chul Lee, Sung Kyu Kim, Tae Sub Park, Deivendran Rengaraj, Kyung Je Park, Hong Jo Lee, Soo Bong Park, Sung Woo Kim, Seong Bok Choi and Jae Yong Han
    Citation: Stem Cell Research & Therapy 2013 4:136
  18. Advanced atherosclerotic lesions are characterized by lipid accumulation, inflammation, and defective efferocytosis. An ideal therapy should address all aspects of this multifactorial disease. Ixmyelocel-T the...

    Authors: Kelly J Ledford, Nikki Murphy, Frank Zeigler and Ronnda L Bartel
    Citation: Stem Cell Research & Therapy 2013 4:135
  19. M2 macrophages promote tissue repair and regeneration through various mechanisms including immunomodulation and scavenging of tissue debris. Delivering increased numbers of these cells to ischemic tissues may ...

    Authors: Kelly J Ledford, Frank Zeigler and Ronnda L Bartel
    Citation: Stem Cell Research & Therapy 2013 4:134
  20. While amniotic mesenchymal cells have been isolated and characterized in different species, amniotic epithelial cells (AECs) have been found only in humans and horses and are recently considered valid candidat...

    Authors: Lucia Rutigliano, Bruna Corradetti, Luisa Valentini, Davide Bizzaro, Aurora Meucci, Fausto Cremonesi and Anna Lange-Consiglio
    Citation: Stem Cell Research & Therapy 2013 4:133
  21. High expression of aldehyde dehydrogenase1A1 (ALDH1A1) is observed in many organs and tumors and may identify benign and cancer stem cell populations.

    Authors: Kalyan J Gangavarapu, Gissou Azabdaftari, Carl D Morrison, Austin Miller, Barbara A Foster and Wendy J Huss
    Citation: Stem Cell Research & Therapy 2013 4:132
  22. Murine models of hind-limb ischemia are frequently used to assess interventions aimed at improving therapeutic angiogenesis in critical limb ischemia. Much of the current focus of angiogenesis lies with mesenc...

    Authors: Garry P Duffy and Caroline C Herron
    Citation: Stem Cell Research & Therapy 2013 4:131
  23. Huntington’s disease (HD) is an autosomal dominant disorder caused by an expanded CAG repeat on the short arm of chromosome 4 resulting in cognitive decline, motor dysfunction, and death, typically occurring 1...

    Authors: Kyle D Fink, Julien Rossignol, Andrew T Crane, Kendra K Davis, Matthew C Bombard, Angela M Bavar, Steven Clerc, Steven A Lowrance, Cheng Song, Laurent Lescaudron and Gary L Dunbar
    Citation: Stem Cell Research & Therapy 2013 4:130
  24. Mesenchymal stem cells (MSCs) have immunosuppressive activity. They do not induce allospecific T cell responses, making them promising tools for reducing the severity of graft versus host disease (GVHD) as wel...

    Authors: Cristina Nazarov, Jessica Lo Surdo, Steven R Bauer and Cheng-Hong Wei
    Citation: Stem Cell Research & Therapy 2013 4:128
  25. The development of an appropriate procedure for lentiviral gene transduction into keratinocyte stem cells is crucial for stem cell biology and regenerative medicine for genetic disorders of the skin. However, ...

    Authors: Daisuke Nanba, Natsuki Matsushita, Fujio Toki and Shigeki Higashiyama
    Citation: Stem Cell Research & Therapy 2013 4:127
  26. The application of mesenchymal stem cells (MSCs) in treating rheumatoid arthritis (RA) has been made possible by the immunosuppressive and differentiation abilities of these cells. A non-invasive means of asse...

    Authors: Hareklea Markides, Oksana Kehoe, Robert H Morris and Alicia J El Haj
    Citation: Stem Cell Research & Therapy 2013 4:126
  27. The ability to self-renew, be easily expanded in vitro and differentiate into different mesenchymal tissues, render mesenchymal stem cells (MSCs) an attractive therapeutic method for degenerative diseases. The su...

    Authors: Andreia Ribeiro, Paula Laranjeira, Sandrine Mendes, Isabel Velada, Cristiana Leite, Pedro Andrade, Francisco Santos, Ana Henriques, Mário Grãos, Carla M P Cardoso, António Martinho, M Luísa Pais, Cláudia Lobato da Silva, Joaquim Cabral, Hélder Trindade and Artur Paiva
    Citation: Stem Cell Research & Therapy 2013 4:125
  28. Ovarian dysfunction frequently occurs in female cancer patients after chemotherapy, but human amniotic epithelial cells (hAECs) that can differentiate into cell types that arise from all three germ layers may ...

    Authors: Fangyuan Wang, Li Wang, Xiaofen Yao, Dongmei Lai and Lihe Guo
    Citation: Stem Cell Research & Therapy 2013 4:124
  29. Administration of bone marrow-derived cells produces beneficial effects in experimental extrapulmonary acute respiratory distress syndrome (ARDS). However, there are controversies regarding the effects of timi...

    Authors: Tatiana Maron-Gutierrez, Johnatas Dutra Silva, Fernanda Ferreira Cruz, Samantha Alegria, Debora Gonçalves Xisto, Edson Fernandes Assis, Hugo Caire Castro-Faria-Neto, Claudia Chimisso Dos Santos, Marcelo Marcos Morales and Patricia Rieken Macedo Rocco
    Citation: Stem Cell Research & Therapy 2013 4:123
  30. On 23 May 2013, the Italian health minister decided to endorse a law regarding controversial stem cell-based therapies in 32 young terminally ill patients, shocking many scientists. According to the internatio...

    Authors: Paola Frati, Giacomo Frati, Matteo Gulino, Gianluca Montanari Vergallo, Alessandro Di Luca and Vittorio Fineschi
    Citation: Stem Cell Research & Therapy 2013 4:122
  31. Tissue factor (TF) is expressed in various types of cells. TF expression is essential for many biological processes, such as blood coagulation and embryonic development, while its high expression in stem cells...

    Authors: Yan-Hui Yu, Deng-Shu Wu, Fang-Fang Huang, Zheng Zhang, Lin-Xin Liu, Jian Zhang, Hui-En Zhan, Min-Yuan Peng, Hui Zeng and Fang-Ping Chen
    Citation: Stem Cell Research & Therapy 2013 4:121
  32. Cell supplementation to the herniated or degenerated intervertebral disc (IVD) is a potential strategy to promote tissue regeneration and slow disc pathology. Human umbilical cord mesenchymal stromal cells (HU...

    Authors: Brian H Chon, Esther J Lee, Liufang Jing, Lori A Setton and Jun Chen
    Citation: Stem Cell Research & Therapy 2013 4:120
  33. The standard procedure for the osteogenic differentiation of multipotent stem cells is treatment of a confluent monolayer with a cocktail of dexamethasone (Dex), ascorbic acid (Asc) and β-glycerophosphate (β-G...

    Authors: Fabian Langenbach and Jörg Handschel
    Citation: Stem Cell Research & Therapy 2013 4:117
  34. Rat middle cerebral artery occlusion (MCAO) model is the most commonly used animal model in ischemic stroke studies. In the model, to increase the amount of stem cells or drugs to enter the brain after deliver...

    Authors: Ling Guo, Jianfeng Ge, Shan Wang, Ying Zhou, Xiaoxiao Wang and Yaojiong Wu
    Citation: Stem Cell Research & Therapy 2013 4:116
  35. Studying cancer tumors’ microenvironment may reveal a novel role in driving cancer progression and metastasis. The biological interaction between stromal (mesenchymal) stem cells (MSCs) and cancer cells remain...

    Authors: Mashael Al-toub, Abdulaziz Almusa, Mohammed Almajed, May Al-Nbaheen, Moustapha Kassem, Abdullah Aldahmash and Nehad M Alajez
    Citation: Stem Cell Research & Therapy 2013 4:114
  36. Treatment of chronic skin wounds is difficult and largely ineffective. Little improvement has been shown in promoting the healing of these wounds in the past few decades. Innovative treatments to enhance chron...

    Authors: Yunling Li, Lei Zheng, Xia Xu, Lili Song, Yin Li, Wei Li, Suhan Zhang, Feng Zhang and Haiyan Jin
    Citation: Stem Cell Research & Therapy 2013 4:113
  37. Knowing the repertoire of cell signaling receptors would provide pivotal insight into the developmental and regenerative capabilities of bone marrow cell (BMC)-derived hematopoietic stem/progenitor cells (HSPC...

    Authors: Khairul Anam and Thomas A Davis
    Citation: Stem Cell Research & Therapy 2013 4:112
  38. Cell-based therapy represents a new frontier in the treatment of a wide variety of human diseases traditionally associated with morbidity outcomes, including those involving inflammation, autoimmunity, tissue ...

    Authors: Ikiru Atsuta, Shiyu Liu, Yasuo Miura, Kentaro Akiyama, Chider Chen, Ying An, Songtao Shi and Fa-Ming Chen
    Citation: Stem Cell Research & Therapy 2013 4:111
  39. MicroRNA-21 (miR-21) functions have been linked to cancer progression and chemo- or radiotherapy resistance. While an increasing number of studies have reported a potential role of miR-21 expression in promoti...

    Authors: Hong-Yo Kang
    Citation: Stem Cell Research & Therapy 2013 4:110
  40. Microspheres fabricated from natural materials serve as a promising biodegradable and biocompatible carrier in a small volume for efficient cell delivery to the lesion of the injured neural tissue to generate ...

    Authors: Li Yao, Francis Phan and Yongchao Li
    Citation: Stem Cell Research & Therapy 2013 4:109
  41. Bones adapt to accommodate the physical forces they experience through changes in architecture and mass. Stem cells differentiate into bone-forming osteoblasts, and mechanical stimulation is involved in this p...

    Authors: Julia C Chen and Christopher R Jacobs
    Citation: Stem Cell Research & Therapy 2013 4:107
  42. Advances in the fields of stem cell biology, biomaterials, and tissue engineering over the last decades have brought the possibility of constructing tissue substitutes with a broad range of applications in reg...

    Authors: Giuseppe Maria de Peppo and Darja Marolt
    Citation: Stem Cell Research & Therapy 2013 4:106

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