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  1. The evolution of articular cartilage repair procedures has resulted in a variety of cell-based therapies that use both autologous and allogeneic mesenchymal stromal cells (MSCs). As these cells are increasingl...

    Authors: Lucienne A. Vonk, Tommy S. de Windt, Ineke C. M. Slaper-Cortenbach and Daniël B. F. Saris
    Citation: Stem Cell Research & Therapy 2015 6:94
    Content type: Review Published on:

  2. Diffuse axonal injury is an extremely common type of traumatic brain injury encountered in motor vehicle crashes, sports injuries, and in combat. Although many cases of diffuse axonal injury result in chronic ...

    Authors: Leyan Xu, Jiwon Ryu, Hakim Hiel, Adarsh Menon, Ayushi Aggarwal, Elizabeth Rha, Vasiliki Mahairaki, Brian J Cummings and Vassilis E Koliatsos
    Citation: Stem Cell Research & Therapy 2015 6:93
    Content type: Research Published on:

  3. Growing evidence has brought stem cell therapy to the forefront as new promising approaches towards stroke treatment. Of all candidate seeding cells, adipose-derived stem cells (ADSCs) are considered as one of...

    Authors: Fei Zhou, Shane Gao, Lin Wang, Chenxi Sun, Lu Chen, Ping Yuan, Haiyang Zhao, Yi Yi, Ying Qin, Zhiqiang Dong, Limei Cao, Haiyan Ren, Liang Zhu, Qiang Li, Bing Lu, Aibin Liang…
    Citation: Stem Cell Research & Therapy 2015 6:92
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:76

  4. Transplantation of bone marrow mesenchymal stem cells (BMSCs) can repair injured hearts. However, whether BMSC populations contain cells with cardiac stem cell characteristics is ill-defined. We report here th...

    Authors: Ranran Ding, Xiaofan Jiang, Yanping Ha, Zhenliang Wang, Junli Guo, Hanguo Jiang, Shaojiang Zheng, Zhihua Shen and Wei Jie
    Citation: Stem Cell Research & Therapy 2015 6:91
    Content type: Research Published on:

  5. The secretion of trophic factors by mesenchymal stromal cells has gained increased interest given the benefits it may bring to the treatment of a variety of traumatic injuries such as skin wounds. Herein, we r...

    Authors: Jorge M Santos, Sérgio P Camões, Elysse Filipe, Madalena Cipriano, Rita N Barcia, Mariana Filipe, Mariana Teixeira, Sandra Simões, Manuela Gaspar, Diogo Mosqueira, Diana S Nascimento, Perpétua Pinto-do-Ó, Pedro Cruz, Helder Cruz, Matilde Castro and Joana P Miranda
    Citation: Stem Cell Research & Therapy 2015 6:90
    Content type: Research Published on:

  6. Advances in tendon engineering with mesenchymal stem cells (MSCs) are hindered by a need for cues to direct tenogenesis, and markers to assess tenogenic state. We examined the effects of factors involved in em...

    Authors: Jeffrey P Brown, Thomas V Galassi, Matteo Stoppato, Nathan R Schiele and Catherine K Kuo
    Citation: Stem Cell Research & Therapy 2015 6:89
    Content type: Research Published on:

  7. Human mesenchymal stem cells (hMSCs) reside in a perivascular niche of the body, suggesting that they interact closely with vascular endothelial cells (ECs) through cell-cell interaction or paracrine signaling...

    Authors: Tsung-Lin Tsai, Bowen Wang, Matthew W Squire, Lian-Wang Guo and Wan-Ju Li
    Citation: Stem Cell Research & Therapy 2015 6:88
    Content type: Research Published on:

  8. Breast cancer progression is promoted by stromal cells that populate the tumors, including cancer-associated fibroblasts (CAFs) and mesenchymal stem/stromal cells (MSCs). The activities of CAFs and MSCs in bre...

    Authors: Christina Katanov, Shalom Lerrer, Yulia Liubomirski, Leonor Leider-Trejo, Tsipi Meshel, Jair Bar, Rotem Feniger-Barish, Iris Kamer, Gali Soria-Artzi, Hadar Kahani, Debabrata Banerjee and Adit Ben-Baruch
    Citation: Stem Cell Research & Therapy 2015 6:87
    Content type: Research Published on:

  10. Skin as the largest and easily accessible organ of the body represents an abundant source of adult stem cells. Among them, dermal stem cells hold great promise in tissue repair and the skin granulation tissue ...

    Authors: Zelin Chen, Tingyu Dai, Xia Chen, Li Tan and Chunmeng Shi
    Citation: Stem Cell Research & Therapy 2015 6:85
    Content type: Research Published on:

  11. The quality of cartilaginous tissue derived from bone marrow mesenchymal stromal stem cell (BMSC) transplantation has been correlated with clinical outcome. Therefore, culture conditions capable of modulating ...

    Authors: Troy D Bornes, Nadr M Jomha, Aillette Mulet-Sierra and Adetola B Adesida
    Citation: Stem Cell Research & Therapy 2015 6:84
    Content type: Research Published on:

  12. Induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) may be suitable for myocardial repair. While their functional and structural properties have been extensively investigated, their response to isch...

    Authors: Andreja Brodarac, Tomo Šarić, Barbara Oberwallner, Shokoufeh Mahmoodzadeh, Klaus Neef, Julie Albrecht, Karsten Burkert, Matteo Oliverio, Filomain Nguemo, Yeong-Hoon Choi, Wolfram F Neiss, Ingo Morano, Jürgen Hescheler and Christof Stamm
    Citation: Stem Cell Research & Therapy 2015 6:83
    Content type: Research Published on:

  13. Mesenchymal stem cells (MSCs)-based therapies have had positive outcomes in animal models of cardiovascular diseases. However, the number and function of MSCs decline with age, reducing their ability to contri...

    Authors: Wenzheng Xia, Fengyun Zhang, Congying Xie, Miaomiao Jiang and Meng Hou
    Citation: Stem Cell Research & Therapy 2015 6:82
    Content type: Research Published on:

  14. Osteosarcoma is the most common primary malignant bone tumor, and the grading of osteosarcoma cells relies on traditional histopathology and molecular biology methods, which require RNA extraction, protein iso...

    Authors: Yi-Hung Chiang, Stewart H Wu, Yi-Chun Kuo, How-Foo Chen, Arthur Chiou and Oscar K Lee
    Citation: Stem Cell Research & Therapy 2015 6:81
    Content type: Research Published on:

  15. Deciduous and permanent human teeth represent an excellent model system to study aging of stromal populations. Aging is tightly connected to self-renewal and proliferation and thus, mapping potential molecular...

    Authors: Nina Kaukua, Mo Chen, Paolo Guarnieri, Markus Dahl, Mei Ling Lim, Tülay Yucel-Lindberg, Erik Sundström, Igor Adameyko, Jeremy J Mao and Kaj Fried
    Citation: Stem Cell Research & Therapy 2015 6:59
    Content type: Research Published on:

  16. A still not well defined proportion of patients with multiple myeloma (MM) and eligible for autologous stem cell transplantation (AuSCT) fails to mobilize CD34+ peripheral blood stem cells (PBSC) at all or to ...

    Authors: Pellegrino Musto, Vittorio Simeon, Alberto Grossi, Francesca Gay, Sara Bringhen, Alessandra Larocca, Roberto Guariglia, Giuseppe Pietrantuono, Oreste Villani, Giovanni D’Arena, Carmela Cuomo, Clelia Musto, Fortunato Morabito, Maria Teresa Petrucci, Massimo Offidani, Elena Zamagni…
    Citation: Stem Cell Research & Therapy 2015 6:64
    Content type: Research Published on:

  17. Transplantation of endothelial progenitor cells (EPCs) restores endothelial function in patients with endothelial dysfunction and initial denudation. The goal of the present study was to determine the effect o...

    Authors: Yangguang Yin, Huanyun Liu, Fangjuan Wang, Lufeng Li, Mengyang Deng, Lan Huang and Xiaohui Zhao
    Citation: Stem Cell Research & Therapy 2015 6:37
    Content type: Research Published on:

  18. Implantation of mesenchymal stem cells (MSCs) has recently been reported to repair tissue injuries through anti-inflammatory and immunosuppressive effects. We established dedifferentiated fat (DFAT) cells that...

    Authors: Takashi Maruyama, Noboru Fukuda, Taro Matsumoto, Koichiro Kano, Morito Endo, Minako Kazama, Tomohiko Kazama, Jin Ikeda, Hiroyuki Matsuda, Takahiro Ueno, Masanori Abe, Kazuyoshi Okada, Masayoshi Soma, Koichi Matsumoto and Hiroshi Kawachi
    Citation: Stem Cell Research & Therapy 2015 6:80
    Content type: Research Published on:

  19. Inflammatory bowel diseases (IBD) are complex multi-factorial diseases with increasing incidence worldwide but their treatment is far from satisfactory. Unconventional strategies have consequently been investi...

    Authors: Antara Banerjee, Debora Bizzaro, Patrizia Burra, Rosa Di Liddo, Surajit Pathak, Diletta Arcidiacono, Andrea Cappon, Patrizio Bo, Maria Teresa Conconi, Marika Crescenzi, Claudia Maria Assunta Pinna, Pier Paolo Parnigotto, Malcolm R Alison, Giacomo Carlo Sturniolo, Renata D’Incà and Francesco Paolo Russo
    Citation: Stem Cell Research & Therapy 2015 6:79
    Content type: Research Published on:

  20. Macrophage-driven inflammation is a key feature of the early period following tendon repair, but excessive inflammation has been associated with poor clinical outcomes. Modulation of the inflammatory environme...

    Authors: Cionne N Manning, Catherine Martel, Shelly E Sakiyama-Elbert, Matthew J Silva, Shivam Shah, Richard H Gelberman and Stavros Thomopoulos
    Citation: Stem Cell Research & Therapy 2015 6:74
    Content type: Research Published on:

  21. Paracrine effects can be exploited in cell-based therapies that secrete factors, such as chemokines and cytokines, and can recruit inflammatory cells to transplants. In this study, mouse adipose tissue-derived...

    Authors: Hidemi Hattori and Masayuki Ishihara
    Citation: Stem Cell Research & Therapy 2015 6:70
    Content type: Research Published on:

  22. Recent studies in the literature have highlighted the critical role played by cell signalling in determining haemopoietic stem cell (HSC) fate within ex vivo culture systems. Stimulatory signals can enhance proli...

    Authors: Joseph D Berry, Pankaj Godara, Petar Liovic and David N Haylock
    Citation: Stem Cell Research & Therapy 2015 6:58
    Content type: Research Published on:

  24. Mesenchymal stem cells (MSCs) have the ability to proliferate in vivo with a large variety of differentiation potentials and therefore are widely used as an ideal material for cell therapy. MSCs derived from pig ...

    Authors: Lei Huang, Chenguang Niu, Belinda Willard, Weimin Zhao, Lan Liu, Wei He, Tianwen Wu, Shulin Yang, Shutang Feng, Yulian Mu, Lemin Zheng and Kui Li
    Citation: Stem Cell Research & Therapy 2015 6:77
    Content type: Research Published on:

  25. Intravenous (IV) injection of mesenchymal stem cells (MSCs) is used to treat systemic human diseases and disorders but is not routinely used in equine therapy. In horses, MSCs are isolated primarily from adipo...

    Authors: Amir Kol, Joshua A Wood, Danielle D Carrade Holt, Jessica A Gillette, Laurie K Bohannon-Worsley, Sarah M Puchalski, Naomi J Walker, Kaitlin C Clark, Johanna L Watson and Dori L Borjesson
    Citation: Stem Cell Research & Therapy 2015 6:73
    Content type: Research Published on:

  26. Healthy bone marrow cell (BMC) infusion improves renal function and limits renal injury in a model of chronic kidney disease (CKD) in rats. However, BMCs derived from rats with CKD fail to retain beneficial ef...

    Authors: Arianne van Koppen, Diana A Papazova, Nynke R Oosterhuis, Hendrik Gremmels, Rachel H Giles, Joost O Fledderus, Jaap A Joles and Marianne C Verhaar
    Citation: Stem Cell Research & Therapy 2015 6:63
    Content type: Research Published on:

  27. The preliminary results of ovarian transplantation in clinical practice are encouraging. However, the follicular depletion caused by ischemic injury is a main concern and is directly related to short-term graf...

    Authors: Luciana Lamarão Damous, Juliana Sanajotti Nakamuta, Ana Elisa Teófilo Saturi de Carvalho, José Maria Soares-Jr, Manuel de Jesus Simões, José Eduardo Krieger and Edmund C Baracat
    Citation: Stem Cell Research & Therapy 2015 6:57
    Content type: Short report Published on:

  28. Human adipose tissue-derived stem cells (hASCs) are attractive cells for therapeutic applications and are currently being evaluated in multiple clinical trials. Prior to their clinical application, hASCs must ...

    Authors: Ana CC Paula, Thaís MM Martins, Alessandra Zonari, Soraia PPJ Frade, Patrícia C Angelo, Dawidson A Gomes and Alfredo M Goes
    Citation: Stem Cell Research & Therapy 2015 6:76
    Content type: Research Published on:

  29. Growing recognition of paracrine mechanisms in stem cell plasticity has resulted in considerable interest in stem cell-derived secretome. The aim of this study was to investigate the effects of lipopolysacchar...

    Authors: Sang Chul Lee, Hye Jin Jeong, Sang Kuon Lee and Say-June Kim
    Citation: Stem Cell Research & Therapy 2015 6:75
    Content type: Research Published on:

  30. Subcutaneous adipose tissue is an interesting source of autologous stem cells with a fundamental role in the pathophysiology of obesity, metabolic syndromes and insulin resistance. We hypothesize that obesity ...

    Authors: Karina R Silva, Sally Liechocki, João R Carneiro, Cesar Claudio-da-Silva, Clarissa M Maya-Monteiro, Radovan Borojevic and Leandra S Baptista
    Citation: Stem Cell Research & Therapy 2015 6:72
    Content type: Research Published on:

  31. Human parthenogenetic embryonic stem cells (hpESCs) are generated from artificially activated oocytes, however, the issue of whether hpESCs have equivalent differentiation ability to human fertilized embryonic...

    Authors: Yang Yu, Qian Gao, Hong-cui Zhao, Rong Li, Jiang-man Gao, Ting Ding, Si-yu Bao, Yue Zhao, Xiao-fang Sun, Yong Fan and Jie Qiao
    Citation: Stem Cell Research & Therapy 2015 6:69
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2015 6:180

  32. Mesenchymal progenitor cells interact with immune cells and modulate inflammatory responses. The cellular characteristics required for this modulation are under fervent investigation. Upon interaction with mac...

    Authors: Jodi F Evans, Veronica Salvador, Sheela George, Cristina Trevino-Gutierrez and Catherine Nunez
    Citation: Stem Cell Research & Therapy 2015 6:56
    Content type: Research Published on:

  33. Previous studies have produced controversial results regarding whether mesenchymal stem cells (MSCs) promote or inhibit tumor development. Given the dual role of MSCs in inflammation and cancer, in this study ...

    Authors: Rui-jing Tang, Su-nan Shen, Xiao-yin Zhao, Yun-zhong Nie, Yu-jun Xu, Jing Ren, Ming-ming Lv, Ya-yi Hou and Ting-ting Wang
    Citation: Stem Cell Research & Therapy 2015 6:71
    Content type: Research Published on:

  34. Osteonecrosis of the femoral head (ONFH) is a degenerative disease progressing to a femoral head (FH) collapse. Injection of osteoprogenitor cells like bone marrow mesenchymal stromal cells (BMSCs) into the FH...

    Authors: Angélique Lebouvier, Alexandre Poignard, Madeleine Cavet, Jérôme Amiaud, Julie Leotot, Philippe Hernigou, Alain Rahmouni, Philippe Bierling, Pierre Layrolle, Hélène Rouard and Nathalie Chevallier
    Citation: Stem Cell Research & Therapy 2015 6:68
    Content type: Research Published on:

  35. Stimulation of mesenchymal stromal cells and adipose tissue-derived stromal cells (ASCs) with vascular endothelial growth factor (VEGF) has been used in multiple animal studies and clinical trials for regenera...

    Authors: Josefine Tratwal, Anders Bruun Mathiasen, Morten Juhl, Sonja Kim Brorsen, Jens Kastrup and Annette Ekblond
    Citation: Stem Cell Research & Therapy 2015 6:62
    Content type: Research Published on:

  36. Mesenchymal stem cells (MSCs) are promising candidates for cell-based therapies. Human platelet lysate represents an efficient alternative to fetal bovine serum for clinical-scale expansion of MSCs. Different ...

    Authors: Chun-yu Li, Xiao-yun Wu, Jia-bei Tong, Xin-xin Yang, Jing-li Zhao, Quan-fu Zheng, Guo-bin Zhao and Zhi-jie Ma
    Citation: Stem Cell Research & Therapy 2015 6:55
    Content type: Research Published on:

  37. Following injury such as stroke, adult mammalian subependymal neural precursor cells (NPCs) are induced to proliferate and migrate toward the lesion site where they differentiate into neural cells, albeit with...

    Authors: Robart Babona-Pilipos, Alex Pritchard-Oh, Milos R Popovic and Cindi M Morshead
    Citation: Stem Cell Research & Therapy 2015 6:67
    Content type: Research Published on:

  38. Diabetes is associated with reduced expression of heme oxygenase-1 (HO-1), a heme-degrading enzyme with cytoprotective and proangiogenic properties. In myoblasts and muscle satellite cells HO-1 improves surviv...

    Authors: Magdalena Kozakowska, Jerzy Kotlinowski, Anna Grochot-Przeczek, Maciej Ciesla, Bartosz Pilecki, Rafal Derlacz, Jozef Dulak and Alicja Jozkowicz
    Citation: Stem Cell Research & Therapy 2015 6:61
    Content type: Research Published on:

  39. This study tested the hypothesis that Major Histocompatibility Complex (MHC) incompatible equine mesenchymal stromal cells (MSCs) would induce cytotoxic antibodies to donor MHC antigens in recipient horses aft...

    Authors: Lynn M Pezzanite, Lisa A Fortier, Douglas F Antczak, Jennifer M Cassano, Margaret M Brosnahan, Donald Miller and Lauren V Schnabel
    Citation: Stem Cell Research & Therapy 2015 6:54
    Content type: Research Published on:

  40. The prevalence of impaired cutaneous wound healing is high and treatment is difficult and often ineffective, leading to negative social and economic impacts for our society. Innovative treatments to improve cu...

    Authors: Leen Bussche, Rebecca M Harman, Bethany A Syracuse, Eric L Plante, Yen-Chun Lu, Theresa M Curtis, Minglin Ma and Gerlinde R Van de Walle
    Citation: Stem Cell Research & Therapy 2015 6:66
    Content type: Research Published on:

  41. Mesenchymal stem cells (MSCs) have potential for re-epithelization and recovery in acute respiratory distress syndrome (ARDS). In a previous in vitro study, the results showed that the canonical Wnt/β-catenin pat...

    Authors: Shi-xia Cai, Ai-ran Liu, Song Chen, Hong-li He, Qi-hong Chen, Jing-yuan Xu, Chun Pan, Yi Yang, Feng-mei Guo, Ying-zi Huang, Ling Liu and Hai-bo Qiu
    Citation: Stem Cell Research & Therapy 2015 6:65
    Content type: Research Published on:

  42. The beta-amyloid (Aβ) peptide and the Aβ-oligomer receptor, prion protein (PrP), both influence neurogenesis. Using in vitro murine neural stem cells (NSCs), we investigated whether Aβ and PrP interact to modify ...

    Authors: Steven J Collins, Carolin Tumpach, Qiao-Xin Li, Victoria Lewis, Timothy M Ryan, Blaine Roberts, Simon C Drew, Victoria A Lawson and Cathryn L Haigh
    Citation: Stem Cell Research & Therapy 2015 6:60
    Content type: Short report Published on:

  43. Chemokine-directed migration is crucial for homing of regenerative cells to the infarcted heart and correlates with outcomes of cell therapy trials. Hence, transplantation of chemokine-responsive bone marrow c...

    Authors: Raimondo Ascione, Jonathan Rowlinson, Elisa Avolio, Rajesh Katare, Marco Meloni, Helen L Spencer, Giuseppe Mangialardi, Caroline Norris, Nicolle Kränkel, Gaia Spinetti, Costanza Emanueli and Paolo Madeddu
    Citation: Stem Cell Research & Therapy 2015 6:53
    Content type: Research Published on:

  44. The study of hematopoiesis has been a focus for developmental biologists for over 100 years. What started as a series of microscopic observations in different animal model systems has since evolved into studie...

    Authors: Haydn C-Y Liang and Juan Carlos Zúñiga-Pflücker
    Citation: Stem Cell Research & Therapy 2015 6:52
    Content type: Review Published on:

  45. ‘Patient-specific’ induced pluripotent stem cells (iPSCs) are attractive because they can generate abundant cells without the risk of immune rejection for cell therapy. Studies have shown that iPSC-derived mes...

    Authors: Guo-wen Hu, Qing Li, Xin Niu, Bin Hu, Juan Liu, Shu-min Zhou, Shang-chun Guo, Hai-li Lang, Chang-qing Zhang, Yang Wang and Zhi-feng Deng
    Citation: Stem Cell Research & Therapy 2015 6:10
    Content type: Research Published on:

  46. The therapeutic potential of acyclic retinoid (ACR), a synthetic retinoid, has been confirmed in experimental and clinical studies. Therapeutic targets include precancerous and cancer stem cells. As ACR is als...

    Authors: Hong-Bin Guan, Yun-Zhong Nie, Yun-Wen Zheng, Kazuya Takiguchi, Hong-Wei Yu, Ran-Ran Zhang, Bin Li, Tomonori Tsuchida and Hideki Taniguchi
    Citation: Stem Cell Research & Therapy 2015 6:51
    Content type: Research Published on:

  47. Stem cell therapy has emerged as potential therapeutic strategy for damaged heart muscles. Umbilical cord blood (UCB) cells are the most prevalent stem cell source available, yet have not been fully tested in ...

    Authors: Saji Oommen, Satsuki Yamada, Susana Cantero Peral, Katherine A Campbell, Elizabeth S Bruinsma, Andre Terzic and Timothy J Nelson
    Citation: Stem Cell Research & Therapy 2015 6:50
    Content type: Research Published on:

  48. Chimeric mice with humanized livers were recently established by transplanting human hepatocytes. This mouse model that is repopulated with functional human hepatocytes could be a useful tool for investigating...

    Authors: Ran-Ran Zhang, Yun-Wen Zheng, Bin Li, Tomonori Tsuchida, Yasuharu Ueno, Yun-Zhong Nie and Hideki Taniguchi
    Citation: Stem Cell Research & Therapy 2015 6:49
    Content type: Research Published on:

  49. Advances in the field of stem cells have led to novel avenues for generating induced pluripotent stem cells (iPSCs) from differentiated somatic cells. iPSCs are typically obtained by the introduction of four f...

    Authors: Christopher B Driscoll, Jason M Tonne, Moustafa El Khatib, Roberto Cattaneo, Yasuhiro Ikeda and Patricia Devaux
    Citation: Stem Cell Research & Therapy 2015 6:48
    Content type: Research Published on:

  50. The therapeutic potential of mesenchymal stem cells (MSCs) for traumatic brain injury (TBI) is attractive. Conducting systematic review and meta-analyses based on data from animal studies can be used to inform...

    Authors: Weijun Peng, Jing Sun, Chenxia Sheng, Zhe Wang, Yang Wang, Chunhu Zhang and Rong Fan
    Citation: Stem Cell Research & Therapy 2015 6:47
    Content type: Research Published on:
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Stem Cell Research & Therapy

ISSN: 1757-6512