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  1. The corneal stroma is being increasingly recognized as a repository for stem cells. Like the limbal and endothelial niches, stromal stem cells often reside in the peripheral cornea and limbus. These peripheral...

    Authors: Khurram Hashmani, Matthew James Branch, Laura Elizabeth Sidney, Permesh Singh Dhillon, Megha Verma, Owen Douglas McIntosh, Andrew Hopkinson and Harminder Singh Dua
    Citation: Stem Cell Research & Therapy 2013 4:75
  2. So far, no effective therapy is available for acute kidney injury (AKI), a common and serious complication with high morbidity and mortality. Interest has recently been focused on the potential therapeutic eff...

    Authors: Xiao Han, Li Zhao, Guodong Lu, Junke Ge, Yalin Zhao, Shulu Zu, Mingzhen Yuan, Yuqiang Liu, Feng Kong, Zhiying Xiao and Shengtian Zhao
    Citation: Stem Cell Research & Therapy 2013 4:74
  3. Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hemat...

    Authors: Wai Feng Lim, Tomoko Inoue-Yokoo, Keai Sinn Tan, Mei I Lai and Daisuke Sugiyama
    Citation: Stem Cell Research & Therapy 2013 4:71
  4. Stroke is a major cause of permanent neurologic damage, with few effective treatments available to restore lost function. Induced pluripotent stem cells (iPSCs) have the potential to generate all cell types in vi...

    Authors: Ting Yuan, Wei Liao, Nian-Hua Feng, Yuan-Lei Lou, Xin Niu, Ai-Jun Zhang, Yang Wang and Zhi-Feng Deng
    Citation: Stem Cell Research & Therapy 2013 4:73
  5. Topical administration of eye drops is the major route for drug delivery to the cornea. Orbital fat-derived stem cells (OFSCs) possess an in vitro corneal epithelial differentiation capacity. Both the safety and ...

    Authors: Ko-Jo Lin, Mei-Xue Loi, Gi-Shih Lien, Chieh-Feng Cheng, Hsiang-Yin Pao, Yun-Chuang Chang, Andrea Tung-Qian Ji and Jennifer Hui-Chun Ho
    Citation: Stem Cell Research & Therapy 2013 4:72
  6. Mesenchymal stem cells (MSCs) are known to migrate to tumor tissues. This behavior of MSCs has been exploited as a tumor-targeting strategy for cell-based cancer therapy. However, the effects of MSCs on tumor ...

    Authors: Ting Zhang, Yuk Wai Lee, Yun Feng Rui, Tin Yan Cheng, Xiao Hua Jiang and Gang Li
    Citation: Stem Cell Research & Therapy 2013 4:70
  7. The use of immortalized neural stem cells either as models of neural development in vitro or as cellular therapies in central nervous system (CNS) disorders has been controversial. This controversy has centered o...

    Authors: Graham Cocks, Nataliya Romanyuk, Takashi Amemori, Pavla Jendelova, Oksana Forostyak, Aaron R Jeffries, Leo Perfect, Sandrine Thuret, Govindan Dayanithi, Eva Sykova and Jack Price
    Citation: Stem Cell Research & Therapy 2013 4:69
  8. A growing number of studies have highlighted the potential of stem cell and more-differentiated neural cell transplantation as intriguing therapeutic approaches for neural repair after spinal cord injury (SCI).

    Authors: Takashi Amemori, Nataliya Romanyuk, Pavla Jendelova, Vit Herynek, Karolina Turnovcova, Pavel Prochazka, Miroslava Kapcalova, Graham Cocks, Jack Price and Eva Sykova
    Citation: Stem Cell Research & Therapy 2013 4:68
  9. Platelet-rich plasma (PRP) is nowadays widely applied in different clinical scenarios, such as orthopedics, ophthalmology and healing therapies, as a growth factor pool for improving tissue regeneration. Studi...

    Authors: Paola Romina Amable, Rosana Bizon Vieira Carias, Marcus Vinicius Telles Teixeira, Ítalo da Cruz Pacheco, Ronaldo José Farias Corrêa do Amaral, José Mauro Granjeiro and Radovan Borojevic
    Citation: Stem Cell Research & Therapy 2013 4:67
  10. Because of their multi/pluripotency and immunosuppressive properties, mesenchymal stem/stromal cells (MSCs) are important tools for treating immune disorders and for tissue repair. The increasing use of MSCs, ...

    Authors: Luc Sensebé, Mélanie Gadelorge and Sandrine Fleury-Cappellesso
    Citation: Stem Cell Research & Therapy 2013 4:66
  11. Mesenchymal stem cells (MSCs) are adult, multipotent, stem cells with immunomodulatory properties. The mechanisms involved in the capacity of MSCs to inhibit the proliferation of proinflammatory T lymphocytes,...

    Authors: Patricia Luz-Crawford, Monica Kurte, Javiera Bravo-Alegría, Rafael Contreras, Estefania Nova-Lamperti, Gautier Tejedor, Danièle Noël, Christian Jorgensen, Fernando Figueroa, Farida Djouad and Flavio Carrión
    Citation: Stem Cell Research & Therapy 2013 4:65
  12. Based on some well-documented reports, we attempted to clarify the antifibrotic mechanisms of human Wharton’s-jelly-derived mesenchymal stromal cells (WJ-MSCs) from the perspective of induction of hepatocyte g...

    Authors: Tao Du, Xiangyu Zou, Jun Cheng, Shuai Wu, Liang Zhong, Guanqun Ju, Jiang Zhu, Guohua Liu, Yingjian Zhu and Shujie Xia
    Citation: Stem Cell Research & Therapy 2013 4:59
  13. Accumulating evidence indicates that the protective effect of mesenchymal stem cells in models of tissue injury is related to the endocrine/pcrine release of factors. The delivery of growth factors, cytokines,...

    Authors: Stefania Bruno and Benedetta Bussolati
    Citation: Stem Cell Research & Therapy 2013 4:55
  14. This study tested the hypothesis that cyclosporine (CsA)-supported syngeneic adipose-derived mesenchymal stem cell (ADMSC) therapy offered superior attenuation of acute ischemia–reperfusion (IR) kidney injury ...

    Authors: Yen-Ta Chen, Chih-Chau Yang, Yen-Yi Zhen, Christopher Glenn Wallace, Jenq-Lin Yang, Cheuk-Kwan Sun, Tzu-Hsien Tsai, Jiunn-Jye Sheu, Sarah Chua, Chia-Lo Chang, Chung-Lung Cho, Steve Leu and Hon-Kan Yip
    Citation: Stem Cell Research & Therapy 2013 4:62
  15. Intraspinal grafting of human neural stem cells represents a promising approach to promote recovery of function after spinal trauma. Such a treatment may serve to: I) provide trophic support to improve surviva...

    Authors: Sebastiaan van Gorp, Marjolein Leerink, Osamu Kakinohana, Oleksandr Platoshyn, Camila Santucci, Jan Galik, Elbert A Joosten, Marian Hruska-Plochan, Danielle Goldberg, Silvia Marsala, Karl Johe, Joseph D Ciacci and Martin Marsala
    Citation: Stem Cell Research & Therapy 2013 4:57
  16. Human hematopoietic stem cells (HSCs) have been clinically used for transplantation and gene and cellular therapy for more than 4 decades. However, this use is limited because of the challenges in the ex vivo cul...

    Authors: Kiranpreet Kaur, Mohammad Reza Mirlashari, Gunnar Kvalheim and Jens Kjeldsen-Kragh
    Citation: Stem Cell Research & Therapy 2013 4:60
  17. Mesenchymal stem cells (MSCs) have the potential for treatment of diabetic cardiomyopathy; however, the repair capability of MSCs declines with age and disease. MSCs from diabetic animals exhibit impaired surv...

    Authors: Mohsin Khan, Fatima Ali, Sadia Mohsin, Shoaib Akhtar, Azra Mehmood, Mahmood S Choudhery, Shaheen N Khan and Sheikh Riazuddin
    Citation: Stem Cell Research & Therapy 2013 4:58
  18. Neural stem cells (NSCs) are among the most promising candidates for cell replacement therapy in neuronal injury and neurodegenerative diseases. One of the remaining obstacles for NSC therapy is to overcome th...

    Authors: Eun Mi Lee, Sunghoon Hurh, Bumrae Cho, Kook-Hwan Oh, Seung U Kim, Charles D Surh, Jonathan Sprent, Jaeseok Yang, Jae Young Kim and Curie Ahn
    Citation: Stem Cell Research & Therapy 2013 4:56
  19. The main aim of this study is to evaluate potential human stem cells, such as dental pulp stem cells and amniotic fluid stem cells, combined with collagen scaffold to reconstruct critical-size cranial bone def...

    Authors: Tullia Maraldi, Massimo Riccio, Alessandra Pisciotta, Manuela Zavatti, Gianluca Carnevale, Francesca Beretti, Giovanni B La Sala, Antonella Motta and Anto De Pol
    Citation: Stem Cell Research & Therapy 2013 4:53
  20. A major determinant of the potential size of cell/scaffold constructs in tissue engineering is vascularization. The aims of this study were twofold: first to determine the in vitro angiogenic and osteogenic gene-...

    Authors: Torbjorn O Pedersen, Anna L Blois, Zhe Xing, Ying Xue, Yang Sun, Anna Finne-Wistrand, Lars A Akslen, James B Lorens, Knut N Leknes, Inge Fristad and Kamal Mustafa
    Citation: Stem Cell Research & Therapy 2013 4:52
  21. Neurons have the intrinsic capacity to produce insulin, similar to pancreatic cells. Adult neural stem cells (NSCs), which give rise to functional neurons, can be established and cultured not only by intracere...

    Authors: Ryo Hidaka, Masanao Machida, Shin Fujimaki, Kazuyuki Terashima, Makoto Asashima and Tomoko Kuwabara
    Citation: Stem Cell Research & Therapy 2013 4:51
  22. Sufficient uterine blood supply is essential for the fetus to develop normally in the uterus. Several mechanisms are involved in the process of vessel development in deciduas and villus. We focus on whether fi...

    Authors: Qiushi Wang, Licong Shen, Wei Huang, Yong Song, Li Xiao, Wenming Xu and Ying Liu
    Citation: Stem Cell Research & Therapy 2013 4:50
  23. SALL4 and BMI-1 are important factors in hematopoiesis. Placental tissue (PT) and umbilical cord blood (CB) are rich in hematopoietic stem/progenitor cells (HSCs/HPCs), but their SALL4 and BMI-1 expression levels...

    Authors: Shaohua Chen, Sichu Liu, Ling Xu, Lijian Yang, Zhenyi Jin, Yu Ma, Bo Li, Xiuli Wu, Jianchang Yang, Yupo Ma and Yangqiu Li
    Citation: Stem Cell Research & Therapy 2013 4:49
  24. Administration of mesenchymal stem cells (MSCs) has been shown to improve renal function in rodent models of chronic kidney disease (CKD), in part by reducing intrarenal inflammation and suppressing fibrosis. ...

    Authors: Jessica M Quimby, Tracy L Webb, Lauren M Habenicht and Steven W Dow
    Citation: Stem Cell Research & Therapy 2013 4:48
  25. Mesenchymal stem cells (MSCs) have attracted increasing interest in the field of oncology because of their inherent capacity to migrate and home tumor tissues. The remarkable tropism of MSCs for tumor microenv...

    Authors: Célia Maria Freitas Gomes
    Citation: Stem Cell Research & Therapy 2013 4:42
  26. Understanding the multiple biological functions played by human mesenchymal stem cells (hMSCs) as well as their development as therapeutics in regenerative medicine or in cancer treatment are major fields of r...

    Authors: Michelle Kéramidas, Florence de Fraipont, Anastassia Karageorgis, Anaïck Moisan, Virginie Persoons, Marie-Jeanne Richard, Jean-Luc Coll and Claire Rome
    Citation: Stem Cell Research & Therapy 2013 4:41
  27. Administration of bone marrow mesenchymal stem cells (MSCs) or secreted microvesicles improves recovery from acute kidney injury (AKI). However, the potential roles and mechanisms are not well understood. In t...

    Authors: Ying Zhou, Huitao Xu, Wenrong Xu, Bingying Wang, Huiyi Wu, Yang Tao, Bin Zhang, Mei Wang, Fei Mao, Yongmin Yan, Shuo Gao, Hongbing Gu, Wei Zhu and Hui Qian
    Citation: Stem Cell Research & Therapy 2013 4:34
  28. Differentiation of vascular endothelial cells (ECs) in clinically relevant numbers for injection into ischaemic areas could offer therapeutic potential in the treatment of cardiovascular conditions, including ...

    Authors: Lynsey Howard, Ruth M Mackenzie, Nikolay A Pchelintsev, Tony McBryan, John D McClure, Martin W McBride, Nicole M Kane, Peter D Adams, Graeme Milligan and Andrew H Baker
    Citation: Stem Cell Research & Therapy 2013 4:36
  29. No comparative study of adipose-derived stem cells (ADSCs) and bone marrow mesenchymal stem cells (BMSCs) by using superparamagnetic iron oxide nanoparticles (SPIOs)-labeling and magnetic resonance imaging (MR...

    Authors: Jingjing Fan, Yanbin Tan, Liyong Jie, Xinying Wu, Risheng Yu and Minming Zhang
    Citation: Stem Cell Research & Therapy 2013 4:44
  30. Administration of bone marrow-derived mesenchymal stem cells (MSCs) after myocardial infarction (MI) results in modest functional improvements. However; the effect of microenvironment changes after MI, such as...

    Authors: Archana V Boopathy, Karl D Pendergrass, Pao Lin Che, Young-Sup Yoon and Michael E Davis
    Citation: Stem Cell Research & Therapy 2013 4:43
  31. In the event of chronic diabetes or burn wounds, accomplishing skin regeneration is a major concern. Autologous skin grafting is the most effective remedy, but the tissue harvest may create more nonhealing wou...

    Authors: Renjith P Nair and Lissy K Krishnan
    Citation: Stem Cell Research & Therapy 2013 4:38
  32. Invariant left-right (LR) patterning or chirality is critical for embryonic development. The loss or reversal of LR asymmetry is often associated with malformations and disease. Although several theories have ...

    Authors: Leo Q Wan, Kacey Ronaldson, Mark Guirguis and Gordana Vunjak-Novakovic
    Citation: Stem Cell Research & Therapy 2013 4:24
  33. Recently, cell-based therapy has gained significant attention for the treatment of central nervous system diseases. Although bone marrow stromal cells (BMSCs) are considered to have good engraftment potential,...

    Authors: Takafumi Mitsuhara, Masaaki Takeda, Satoshi Yamaguchi, Tomotaka Manabe, Masaya Matsumoto, Yumi Kawahara, Louis Yuge and Kaoru Kurisu
    Citation: Stem Cell Research & Therapy 2013 4:35
  34. The field of regenerative medicine is approaching translation to clinical practice, and significant safety concerns and knowledge gaps have become clear as clinical practitioners are considering the potential ...

    Authors: John Harding, R Michael Roberts and Oleg Mirochnitchenko
    Citation: Stem Cell Research & Therapy 2013 4:23
  35. Loss of adult stem cell function during aging contributes to impaired tissue regeneration. Here, we tested the aging-related decline in regeneration potential of adult stem cells residing in the skeletal muscle.

    Authors: Minjung Song, Mitra Lavasani, Seth D Thompson, Aiping Lu, Bahar Ahani and Johnny Huard
    Citation: Stem Cell Research & Therapy 2013 4:33
  36. Cell therapy using adipose-derived stem cells has been reported to improve chronic wounds via differentiation and paracrine effects. One such strategy is to deliver stem cells in hydrogels, which are studied i...

    Authors: Waqar Hassan, Yixiao Dong and Wenxin Wang
    Citation: Stem Cell Research & Therapy 2013 4:32
  37. We hypothesized that dipeptidyl peptidase-IV (DPP4) may impair angiogenesis, endothelial function, and the circulating number of endothelial progenitor cells (EPC) in a model of critical limb ischemia (CLI) th...

    Authors: Cheuk-Kwan Sun, Steve Leu, Jiunn-Jye Sheu, Tzu-Hsien Tsai, Hsin-Chin Sung, Yung-Lung Chen, Sheng-Ying Chung, Sheung-Fat Ko, Hsueh-Wen Chang and Hon-Kan Yip
    Citation: Stem Cell Research & Therapy 2013 4:31
  38. Prior in vivo murine studies suggest circadian oscillations for hematopoietic stem cell release, which are maintained following administration of granulocyte colony-stimulating factor (G-CSF) or plerixafor. Furth...

    Authors: Patricia A Shi, Luis M Isola, Janice L Gabrilove, Erin L Moshier, James H Godbold, Lorraine K Miller and Paul S Frenette
    Citation: Stem Cell Research & Therapy 2013 4:30

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