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  1. Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic fibroblast-like cells that can differentiate into cells of multiple lineages, such as chondrocytes, osteoblasts, adipocytes, myo...

    Authors: Xiaomo Wu, Ju Jiang, Zhongkai Gu, Jinyan Zhang, Yang Chen and Xiaolong Liu
    Citation: Stem Cell Research & Therapy 2020 11:345
    Content type: Review Published on:

  2. Inadequate vascularization is a challenge in bone tissue engineering because internal cells are prone to necrosis due to a lack of nutrient supply. Rat bone marrow-derived mesenchymal stem cells (rBMSCs) and h...

    Authors: Miaomiao Chai, Ce Gu, Qihua Shen, Jiaxing Liu, Yi Zhou, Ziyang Jin, Wanli Xiong, Yan Zhou and Wensong Tan
    Citation: Stem Cell Research & Therapy 2020 11:343
    Content type: Research Published on:

  3. Differentiation of mouse trophoblast stem cells (TSCs) to trophoblast giant cells (TGCs) has been widely used as a model system to study placental development and function. While several differentially express...

    Authors: Rahim Ullah, Ambreen Naz, Hafiza Sara Akram, Zakir Ullah, Muhammad Tariq, Aziz Mithani and Amir Faisal
    Citation: Stem Cell Research & Therapy 2020 11:342
    Content type: Research Published on:

  4. The skeletal muscle regeneration relays on the satellite cells which are stem cells located between basal lamina and plasmalemma of muscle fiber. In the injured muscles, the satellite cells become activated, s...

    Authors: Bartosz Mierzejewski, Iwona Grabowska, Daniel Jackowski, Aliksandra Irhashava, Zuzanna Michalska, Władysława Stremińska, Katarzyna Jańczyk-Ilach, Maria Anna Ciemerych and Edyta Brzoska
    Citation: Stem Cell Research & Therapy 2020 11:341
    Content type: Research Published on:

  5. In the clinical study by Le Thi Bich et al., allogeneic expanded umbilical cord-derived mesenchymal stem cells (UC-MSCs) were intravenously infused to treat patients with chronic obstructive pulmonary disease ...

    Authors: Talita Stessuk and João Tadeu Ribeiro-Paes
    Citation: Stem Cell Research & Therapy 2020 11:340
    Content type: Commentary Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:60

  6. It has been reported that the high-dosage administration of domestically approved pharmaceutical drugs, especially granulocyte colony-stimulating factor (G-CSF) and romiplostim (RP), is a rapid and appropriate...

    Authors: Masaru Yamaguchi, Marino Suzuki, Moeri Funaba, Akane Chiba and Ikuo Kashiwakura
    Citation: Stem Cell Research & Therapy 2020 11:339
    Content type: Research Published on:

  7. The repair of critical-sized bone defect represents a challenging problem in bone tissue engineering. To address the most important problem in bone defect repair, namely insufficient blood supply, this study a...

    Authors: Yuanjia He, Shuang Lin, Qiang Ao and Xiaoning He
    Citation: Stem Cell Research & Therapy 2020 11:338
    Content type: Research Published on:

  8. Selected placental mesenchymal stromal cells isolated from the fetal mesenchymal placental tissues (f-hPSCs) were tested as cell therapy of lethal acute radiation syndrome (ARS) with bone marrow regeneration a...

    Authors: Evgenia Volinsky, Astar Lazmi-Hailu, Nerel Cohen, Boaz Adani, Mohammad Faroja, Myriam Grunewald and Raphael Gorodetsky
    Citation: Stem Cell Research & Therapy 2020 11:337
    Content type: Research Published on:

  9. Diabetic nephropathy (DN) is one of the most serious complications of diabetes and the leading cause of end-stage chronic kidney disease. Currently, there are no effective drugs for treating DN. Therefore, nov...

    Authors: E Xiang, Bing Han, Quan Zhang, Wei Rao, Zhangfan Wang, Cheng Chang, Yaqi Zhang, Chengshu Tu, Changyong Li and Dongcheng Wu
    Citation: Stem Cell Research & Therapy 2020 11:336
    Content type: Research Published on:

  10. Mesenchymal stem cells, including those derived from human adipose tissue (hASCs), are currently being widely investigated for cell therapy. However, when transplanted at the site of injury, the survival and e...

    Authors: Patricia Garrido-Pascual, Ana Alonso-Varona, Begoña Castro, María Burón and Teodoro Palomares
    Citation: Stem Cell Research & Therapy 2020 11:335
    Content type: Research Published on:

  11. Stem cells, including induced pluripotent stem cells (iPSCs), have tremendous potential in health care, though with several significant limitations. Each of the limitations, including immunogenicity, may block...

    Authors: Xiaokai Wang, Meng Lu, Xiaoyu Tian, Yansong Ren, Yijun Li, Meng Xiang and Sifeng Chen
    Citation: Stem Cell Research & Therapy 2020 11:334
    Content type: Research Published on:

  12. Pulpitis is a common dental disease characterized by sustained inflammation and impaired pulp self-repair. Mesenchymal stem cell-based minimally invasive vital pulp therapy (MSC-miVPT) is a potential treatment...

    Authors: Hong Hong, Xiaochuan Chen, Kun Li, Nan Wang, Mengjie Li, Bo Yang, Xiaoqi Yu and Xi Wei
    Citation: Stem Cell Research & Therapy 2020 11:333
    Content type: Research Published on:

  13. Cell therapy using hepatocytes derived from stem cells has been regarded as a promising alternate to liver transplantation. However, the heterogeneity of these hepatocytes makes them unsuitable for therapeutic...

    Authors: Ja Sung Choi, In Sil Jeong, Young-Jin Park and Sung-Whan Kim
    Citation: Stem Cell Research & Therapy 2020 11:332
    Content type: Research Published on:

  15. Mesenchymal stem cells (MSCs) have a limited self-renewal ability, impaired multi-differentiation potential, and undetermined cell senescence during in vitro series expansion. To address this concern, we inves...

    Authors: Zeyuan Cao, Yunyi Xie, Le Yu, Yi Li and Yan Wang
    Citation: Stem Cell Research & Therapy 2020 11:329
    Content type: Research Published on:

  16. Cell-based tissue engineering represents a promising management for meniscus repair and regeneration. The present study aimed to investigate whether the injection of parathyroid hormone (PTH) (1-34) could prom...

    Authors: Wen Zhao, Tong Zou, Hao Cui, Yangou Lv, Dengke Gao, Chenmei Ruan, Xia Zhang and Yihua Zhang
    Citation: Stem Cell Research & Therapy 2020 11:328
    Content type: Research Published on:

  17. Despite the potential, bone marrow-derived mesenchymal stem cells (BMSCs) show limitations for beta (ß)-cell replacement therapy due to inefficient methods to deliver BMSCs into pancreatic lineage. In this stu...

    Authors: Nidheesh Dadheech, Abhay Srivastava, Mitul Vakani, Paresh Shrimali, Ramesh Bhonde and Sarita Gupta
    Citation: Stem Cell Research & Therapy 2020 11:327
    Content type: Research Published on:

  18. Periodontal ligament stem cells (PDLSCs) have many applications in the field of cytotherapy, tissue engineering, and regenerative medicine. However, the effect of age on the biological and immunological charac...

    Authors: Xiaoyu Li, Bowen Zhang, Hong Wang, Xiaolu Zhao, Zijie Zhang, Gang Ding and Fulan Wei
    Citation: Stem Cell Research & Therapy 2020 11:326
    Content type: Research Published on:

  19. Mesenchymal stem cells (MSCs) can regulate innate and adaptive immune systems through interacting with immune cells directly and secreting multiple soluble factors. Due to their immunosuppressive properties, M...

    Authors: Jingjing Qi, Xiaojun Tang, Wenchao Li, Weiwei Chen, Genhong Yao and Lingyun Sun
    Citation: Stem Cell Research & Therapy 2020 11:325
    Content type: Research Published on:

  20. Treating patients with end-stage diffuse coronary artery disease (EnD-CAD) unsuitable for coronary intervention remains a clinical challenge. They usually express refractory angina and have a high risk of mort...

    Authors: Pei-Hsun Sung, Hsin-Ju Chiang, Yi-Chen Li, John Y. Chiang, Chi-Hsiang Chu, Pei-Lin Shao, Fan-Yen Lee, Mel S. Lee and Hon-Kan Yip
    Citation: Stem Cell Research & Therapy 2020 11:324
    Content type: Research Published on:

  21. Extracellular vesicles (EVs) from human mesenchymal stem cells (hMSCs) are known to be mediators of intercellular communication and have been suggested as possible therapeutic agents in many diseases. Their po...

    Authors: Daphne Hingert, Karin Ekström, Jonathan Aldridge, Rosella Crescitelli and Helena Brisby
    Citation: Stem Cell Research & Therapy 2020 11:323
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:443

  22. Burns remain a serious public health problem with high morbidity and mortality rates worldwide. Although there are various treatment options available, there is no consensus on the best treatment for severe bu...

    Authors: Yuan Li, Wei-dong Xia, Leanne Van der Merwe, Wen-tong Dai and Cai Lin
    Citation: Stem Cell Research & Therapy 2020 11:322
    Content type: Review Published on:

  23. Bone marrow stromal cells (BMSC) have promise in cartilage tissue engineering, but for their potential to be fully realised, the propensity to undergo hypertrophy must be mitigated. The literature contains div...

    Authors: Ena Music, Kathryn Futrega, James S. Palmer, Mackenzie Kinney, Bill Lott, Travis J. Klein and Michael R. Doran
    Citation: Stem Cell Research & Therapy 2020 11:321
    Content type: Research Published on:

  24. There are multiple promising treatment strategies for central nervous system trauma and disease. However, to develop clinically potent and safe treatments, models of human-specific conditions are needed to com...

    Authors: Chenhong Lin, Cinzia Calzarossa, Teresa Fernandez-Zafra, Jia Liu, Xiaofei Li, Åsa Ekblad-Nordberg, Erika Vazquez-Juarez, Simone Codeluppi, Lena Holmberg, Maria Lindskog, Per Uhlén and Elisabet Åkesson
    Citation: Stem Cell Research & Therapy 2020 11:320
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:369

  25. Gestational diabetes (GDM) is a common complication of pregnancy. The impact of pregnancy complications on placental function suggests that extraembryonic stem cells in the placenta may also be affected during...

    Authors: Liyun Chen, Chung-Teng Wang, Nicholas R. Forsyth and Pensee Wu
    Citation: Stem Cell Research & Therapy 2020 11:319
    Content type: Research Published on:

  26. MicroRNAs (miRNAs) play a role in regulating osteogenic differentiation (OD) of mesenchymal stem cells by inhibiting mRNAs translation under cyclic strain. miR-503-3p was downregulated in OD of human adipose-d...

    Authors: Yadong Luo, Xu Ding, Huan Ji, Meng Li, Haiyang Song, Sheng Li, Chenxing Wang, Heming Wu and Hongming Du
    Citation: Stem Cell Research & Therapy 2020 11:318
    Content type: Research Published on:

  27. Upon migrating to the injured sites, bone marrow mesenchymal stem cells (BMSCs) play critical roles in the repair of bone lesion caused by chronic apical periodontitis. Emerging evidences have shown that Enteroco...

    Authors: Mingwei Li, Lifan Wei, Wei Zhou, Zhiyan He, Shujun Ran and Jingping Liang
    Citation: Stem Cell Research & Therapy 2020 11:317
    Content type: Research Published on:

  28. MSCs isolated from bone marrow (BM-MSCs) have well-established chondrogenic potential, but MSCs derived from the synovial membrane (SM-MSCs) and synovial fluid (SF-MSCs) are thought to possess superior chondro...

    Authors: Paul Neybecker, Christel Henrionnet, Elise Pape, Laurent Grossin, Didier Mainard, Laurent Galois, Damien Loeuille, Pierre Gillet and Astrid Pinzano
    Citation: Stem Cell Research & Therapy 2020 11:316
    Content type: Research Published on:

  30. Embryonic stem cells (ESCs) are important source of clinical stem cells for therapy, so dissecting the functional gene regulatory network involved in their self-renewal and proliferation is an urgent task. We ...

    Authors: Jingwen Wang, Jiahui Liu, Miaoman Ye, Feng Liu, Su Wu, Junjiu Huang and Guang Shi
    Citation: Stem Cell Research & Therapy 2020 11:314
    Content type: Research Published on:

  31. Small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSC) derived from human induced pluripotent stem cells (iPSC, iMSC-sEV) are considered to have great potential in treating ischemic diseas...

    Authors: Yuguo Xia, Xiaozheng Ling, Guowen Hu, Qingwei Zhu, Juntao Zhang, Qing Li, Bizeng Zhao, Yang Wang and Zhifeng Deng
    Citation: Stem Cell Research & Therapy 2020 11:313
    Content type: Research Published on:

  32. Adipose-derived stem cells (ADSCs) have become one of the most utilized adult stem cells due to their abundance and accessibility. Recent studies have shown that paracrine cytokines, exosomes, and other active...

    Authors: Yuan Cai, Jianyi Li, Changsha Jia, Yunfan He and Chengliang Deng
    Citation: Stem Cell Research & Therapy 2020 11:312
    Content type: Review Published on:

  33. T helper 17 cells (Th17)/regulatory T cells (Treg), as subtypes of CD4+ T cells, play an important role in the inflammatory response of acute respiratory distress syndrome (ARDS). However, there is still a lack o...

    Authors: Jianxiao Chen, Xiwen Zhang, Jianfeng Xie, Ming Xue, Ling Liu, Yi Yang and Haibo Qiu
    Citation: Stem Cell Research & Therapy 2020 11:311
    Content type: Research Published on:

  34. Adipose-derived mesenchymal stem cells (AD-MSCs) are a type of stem cell that is abundant and widely used. The molecular characteristics of AD-MSCs from different passages from donors of different ages have no...

    Authors: Guan-Ming Lu, Yong-Xian Rong, Zhi-Jie Liang, Dong-Lin Hunag, Yan-Fei Ma, Zhi-Zhai Luo, Fang-Xiao Wu, Xin-Heng Liu, Yu Liu, Steven Mo, Zhong-Quan Qi and Hong-Mian Li
    Citation: Stem Cell Research & Therapy 2020 11:310
    Content type: Research Published on:

  35. Organoids play an important role in basic research, drug screening, and regenerative medicine. Here, we aimed to develop a novel kind of three-dimensional (3D) organoids generated from urine-derived stem cells...

    Authors: Guoliang Sun, Beichen Ding, Meimei Wan, Liang Chen, John Jackson and Anthony Atala
    Citation: Stem Cell Research & Therapy 2020 11:309
    Content type: Research Published on:

  36. Multiple strategies have been proposed to promote the differentiation potential of mesenchymal stem cells (MSCs), which is the fundamental property in tissue formation and regeneration. However, these strategi...

    Authors: Kejia Li, Tong Ning, Hao Wang, Yangzi Jiang, Jue Zhang and Zigang Ge
    Citation: Stem Cell Research & Therapy 2020 11:308
    Content type: Research Published on:

  37. Stem cells have a vast range of functions from tissue regeneration to immunoregulation. They have the ability to modulate immune responses and change the progression of different inflammatory and autoimmune di...

    Authors: Sara Shamdani, Georges Uzan and Sina Naserian
    Citation: Stem Cell Research & Therapy 2020 11:307
    Content type: Viewpoint Published on:

  38. 7-Methylguanosine (m7G) is one of the most conserved modifications in nucleosides within tRNAs and rRNAs. It plays essential roles in the regulation of mRNA export, splicing, and translation. Recent studies highl...

    Authors: Yujie Deng, Zhongyang Zhou, Weidong Ji, Shuibin Lin and Min Wang
    Citation: Stem Cell Research & Therapy 2020 11:306
    Content type: Research Published on:

  39. Acute respiratory distress syndrome (ARDS) develops rapidly and has a high mortality rate. Survivors usually have low quality of life. Current clinical management strategies are respiratory support and restric...

    Authors: Kun Xiao, Fei Hou, Xiuyu Huang, Binbin Li, Zhi Rong Qian and Lixin Xie
    Citation: Stem Cell Research & Therapy 2020 11:305
    Content type: Review Published on:

  40. Canine inflammatory brain disease (IBD) is a severe inflammatory disorder characterized by infiltration of activated immune cell subsets into the brain and spinal cord. Multipotent mesenchymal stromal cells (M...

    Authors: Rogério Martins Amorim, Kaitlin C. Clark, Naomi J. Walker, Priyadarsini Kumar, Kyle Herout, Dori L. Borjesson and Aijun Wang
    Citation: Stem Cell Research & Therapy 2020 11:304
    Content type: Research Published on:

  41. The epidermis, which is the outermost layer of mammalian skin, provides an essential barrier that is essential for maintenance of life. The epidermis is a stratified epithelium, which is maintained by the prol...

    Authors: Ronghua Yang, Shuai Yang, Jingling Zhao, Ximin Hu, Xiaodong Chen, Jingru Wang, Julin Xie and Kun Xiong
    Citation: Stem Cell Research & Therapy 2020 11:303
    Content type: Review Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:183

  42. Intracavernous injection of mesenchymal stem cells (MSCs) is a promising method for diabetic mellitus-induced erectile dysfunction (DMED), but short survival time of MSCs in cavernous is a fatal defect for the...

    Authors: Haoran Wang, Keqin Zhang, Zheng Ruan, Dingqi Sun, Hui Zhang, Guiting Lin, Liangliang Hu, Shengtian Zhao and Qiang Fu
    Citation: Stem Cell Research & Therapy 2020 11:302
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:47

  43. Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first transplantation of ex vivo cult...

    Authors: Joao Victor Cabral, Catherine Joan Jackson, Tor Paaske Utheim and Katerina Jirsova
    Citation: Stem Cell Research & Therapy 2020 11:301
    Content type: Review Published on:

  44. Despite recent advances in neonatal care, sepsis remains a leading cause of mortality in neonates. Mesenchymal stem cells derived from various tissues, such as bone marrow, umbilical cord, and adipose tissue, ...

    Authors: Yu Sato, Daigo Ochiai, Yushi Abe, Hirotaka Masuda, Marie Fukutake, Satoru Ikenoue, Yoshifumi Kasuga, Masayuki Shimoda, Yae Kanai and Mamoru Tanaka
    Citation: Stem Cell Research & Therapy 2020 11:300
    Content type: Research Published on:

  45. Stem cell therapies have been widely investigated for their healing effects. However, the translation of these therapies has been hampered by the requirement to deliver live allogeneic or autologous cells dire...

    Authors: Parinaz Ahangar, Stuart J. Mills, Louise E. Smith, Xanthe L. Strudwick, Anthony E. Ting, Bart Vaes and Allison J. Cowin
    Citation: Stem Cell Research & Therapy 2020 11:299
    Content type: Research Published on:

  46. Diabetic patients suffer from impaired wound healing. Mesenchymal stem cell (MSC) therapy represents a promising approach toward improving skin wound healing through the release of soluble growth factors and c...

    Authors: Yongfa Sun, Lili Song, Yong Zhang, Hongjun Wang and Xiao Dong
    Citation: Stem Cell Research & Therapy 2020 11:298
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:82

  47. Cellular replacement strategies using human induced pluripotent stem cells (iPSCs) and their cardiac derivatives are emerging as novel treatments for post-myocardial infarction (MI) heart failure (HF); however...

    Authors: Xin Jiang, Ziyi Yang and Ming Dong
    Citation: Stem Cell Research & Therapy 2020 11:297
    Content type: Research Published on:

  48. The oral cavity is a complex environment in which periodontal tissue is constantly stimulated by external microorganisms and mechanical forces. Proper mechanical force helps maintain periodontal tissue homeost...

    Authors: Pei-ying Lv, Peng-fei Gao, Guang-jie Tian, Yan-yan Yang, Fei-fei Mo, Zi-hui Wang, Lu Sun, Ming-jie Kuang and Yong-lan Wang
    Citation: Stem Cell Research & Therapy 2020 11:295
    Content type: Research Published on:

  49. This study was designed to determine the effect of human umbilical cord multipotent mesenchymal stromal cells (hUC-MSC) on acute ischemia/reperfusion (I/R) injury of spermatogenic cells.

    Authors: Liang Zhong, Mengbo Yang, Xiangyu Zou, Tao Du, Huiming Xu and Jie Sun
    Citation: Stem Cell Research & Therapy 2020 11:294
    Content type: Research Published on:

  50. There have been limited advances in the treatment of bone and joint infections, which currently involves a combination of surgery and antibiotic administration. There is a timely need in orthopedics to develop...

    Authors: Haruyo Yagi, Antonia F. Chen, David Hirsch, Adam C. Rothenberg, Jian Tan, Peter G. Alexander and Rocky S. Tuan
    Citation: Stem Cell Research & Therapy 2020 11:293
    Content type: Research Published on:
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