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  1. Primary mesenchymal stem cells (MSCs) are fraught with aging-related shortfalls. Human-induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) have been shown to be a useful clinically relevant source of MSC...

    Authors: Lucas-Sebastian Spitzhorn, Matthias Megges, Wasco Wruck, Md Shaifur Rahman, Jörg Otte, Özer Degistirici, Roland Meisel, Rüdiger Volker Sorg, Richard O. C. Oreffo and James Adjaye
    Citation: Stem Cell Research & Therapy 2019 10:100
  2. The manufacture of mesenchymal stem/stromal cells (MSCs) for clinical use needs to be cost effective, safe and scaled up. Current methods of expansion on tissue culture plastic are labour-intensive and involve...

    Authors: Claire Mennan, John Garcia, Sally Roberts, Charlotte Hulme and Karina Wright
    Citation: Stem Cell Research & Therapy 2019 10:99
  3. The original article [1] was submitted and published without co-author Hong Chen’s permission.

    Authors: Xuejiao Sun, Jianyuan Song, Hailong Huang, Hong Chen and Kun Qian
    Citation: Stem Cell Research & Therapy 2019 10:97

    The original article was published in Stem Cell Research & Therapy 2018 9:315

  4. Studies have shown that transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) protects against brain damage. However, the low survival number of transplanted BMSCs remains a pertinent challenge...

    Authors: Jiangnan Hu, Lefu Chen, Xujun Huang, Ke Wu, Saidan Ding, Weikan Wang, Brian Wang, Charity Smith, Changhong Ren, Haoqi Ni, Qichuan ZhuGe and Jianjing Yang
    Citation: Stem Cell Research & Therapy 2019 10:96
  5. It is confirmed that adipose-derived stem cells (ADSCs) transplantation effectively relieves kidney fibrosis and type 2 diabetes disease in mice. Currently, exosome from urine-derived stem cells (USCs) can pro...

    Authors: Juan Jin, Yifen Shi, Jianguang Gong, Li Zhao, Yiwen Li, Qiang He and He Huang
    Citation: Stem Cell Research & Therapy 2019 10:95
  6. The skin is the largest organ of the body, which meets the environment most directly. Thus, the skin is vulnerable to various damages, particularly burn injury. Skin wound healing is a serious interaction betw...

    Authors: Anastasia Shpichka, Denis Butnaru, Evgeny A. Bezrukov, Roman B. Sukhanov, Anthony Atala, Vitaliy Burdukovskii, Yuanyuan Zhang and Peter Timashev
    Citation: Stem Cell Research & Therapy 2019 10:94
  7. Adipose-derived mesenchymal stromal cells (ADSCs) are multipotent stromal cells. The cells secrete a number of cytokines and growth factors and show immunoregulatory and proangiogenic properties. Their propert...

    Authors: Ewelina Pilny, Ryszard Smolarczyk, Magdalena Jarosz-Biej, Alina Hadyk, Agnieszka Skorupa, Mateusz Ciszek, Łukasz Krakowczyk, Natalia Kułach, Danuta Gillner, Maria Sokół, Stanisław Szala and Tomasz Cichoń
    Citation: Stem Cell Research & Therapy 2019 10:93
  8. Vascular injury is one of the most common detrimental effects of cancer radiotherapy on healthy tissues. Since the efficacy of current preventive and therapeutic strategies remains limited, the exploration of ...

    Authors: Xuan Tao, Mingyang Sun, Min Chen, Rongchao Ying, Wenjie Su, Jian Zhang, Xiaodong Xie, Wei Wei and Xiaohu Meng
    Citation: Stem Cell Research & Therapy 2019 10:92
  9. Adipose-derived mesenchymal stem cells (ADMSCs) are considered an efficient and important candidate for male infertility treatment because they contain pluripotent stem cells, which can differentiate into all ...

    Authors: Yanxia Luo, Lili Xie, Ali Mohsin, Waqas Ahmed, Chenze Xu, Yan Peng, Haifeng Hang, Yingping Zhuang, Ju Chu and Meijin Guo
    Citation: Stem Cell Research & Therapy 2019 10:91
  10. Sulfur mustard (SM) is a notorious chemical warfare agent that can cause severe acute lung injury (ALI), in addition to other lesions. Currently, effective medical countermeasures for SM are lacking. Bone marr...

    Authors: Yongwei Feng, Qingqiang Xu, Yuyan Yang, Wenwen Shi, Wenqi Meng, Hao Zhang, Xiaowen He, Mingxue Sun, Yongchun Chen, Jie Zhao, Zhenhong Guo and Kai Xiao
    Citation: Stem Cell Research & Therapy 2019 10:90
  11. Human dental pulp stem cell (DPSC)-mediated regenerative endodontics is a promising therapy for damaged teeth; however, the hypoxic environment in root canals can affect tissue regeneration. In this study, we ...

    Authors: Ruitang Shi, Haoqing Yang, Xiao Lin, Yangyang Cao, Chen Zhang, Zhipeng Fan and Benxiang Hou
    Citation: Stem Cell Research & Therapy 2019 10:89
  12. Human mesenchymal stem cell (MSC)-based tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene delivery is regarded as an effective treatment for glioblastoma (GBM). However, adverse-free target ...

    Authors: Man Li, Shoujia Sun, Sean Dangelmajer, Quan Zhang, Junwen Wang, Feng Hu, Fangyong Dong, Ulf D. Kahlert, Mingxin Zhu and Ting Lei
    Citation: Stem Cell Research & Therapy 2019 10:88
  13. Wound healing is the physiologic response to a disruption in normal skin architecture and requires both spatial and temporal coordination of multiple cell types and cytokines. This complex process is prone to ...

    Authors: Jolanta Gorecka, Valentyna Kostiuk, Arash Fereydooni, Luis Gonzalez, Jiesi Luo, Biraja Dash, Toshihiko Isaji, Shun Ono, Shirley Liu, Shin Rong Lee, Jianbiao Xu, Jia Liu, Ryosuke Taniguchi, Bogdan Yastula, Henry C. Hsia, Yibing Qyang…
    Citation: Stem Cell Research & Therapy 2019 10:87
  14. Senescent cells exert a significant influence over their surrounding cellular environment. Senescent chondrocytes (SnChos) were found to be accumulated in degenerated cartilage present in joints affected by os...

    Authors: Xu Cao, Pan Luo, Junjie Huang, Chi Liang, Jinshen He, Zili Wang, Dongyong Shan, Cheng Peng and Song Wu
    Citation: Stem Cell Research & Therapy 2019 10:86
  15. Islets of Langerhans transplantation is a promising therapy for type 1 diabetes mellitus, but this technique is compromised by transplantation stresses including inflammation. In other tissues, co-transplantat...

    Authors: Camille Laporte, Emily Tubbs, Justine Cristante, Anne-Sophie Gauchez, Sandra Pesenti, Frédéric Lamarche, Cécile Cottet-Rousselle, Catherine Garrel, Anaick Moisan, Jean-Marc Moulis, Eric Fontaine, Pierre-Yves Benhamou and Sandrine Lablanche
    Citation: Stem Cell Research & Therapy 2019 10:85
  16. Acute liver failure (ALF) is a complicated clinical syndrome associated with high mortality, with liver transplantation as the only treatment option. Treatment of mesenchymal stem cells has shown a potential t...

    Authors: Gang Guo, Xiang Zhuang, Qing Xu, Zhenru Wu, Yongjie Zhu, Yongjie Zhou, Yuanmin Li, Yanrong Lu, Bo Zhang, Prue Talbot, Jiayu Liao, Junjun She, Hong Bu and Yujun Shi
    Citation: Stem Cell Research & Therapy 2019 10:84
  17. A well-characterized method has not yet been established to reproducibly, efficiently, and safely isolate large numbers of clinical-grade multipotent human neural stem cells (hNSCs) from embryonic stem cells (...

    Authors: Dasa Bohaciakova, Marian Hruska-Plochan, Rachel Tsunemoto, Wesley D. Gifford, Shawn P. Driscoll, Thomas D. Glenn, Stephanie Wu, Silvia Marsala, Michael Navarro, Takahiro Tadokoro, Stefan Juhas, Jana Juhasova, Oleksandr Platoshyn, David Piper, Vickie Sheckler, Dara Ditsworth…
    Citation: Stem Cell Research & Therapy 2019 10:83
  18. Bone marrow stromal cells (BMSCs) are extensively used in regeneration therapy and cytology experiments simulate how BMSCs respond to radiation. Due to the small number and the heterogeneity of primary isolate...

    Authors: Yang Xiang, Chun Wu, Jiang Wu, Weili Quan, Chao Cheng, Jian Zhou, Li Chen, Lixin Xiang, Fengjie Li, Kebin Zhang, Qian Ran, Yi Zhang and Zhongjun Li
    Citation: Stem Cell Research & Therapy 2019 10:82
  19. Embryonic Sertoli cells (eSCs) play an important role in sex determination and in male gonad development which makes them a very useful cell type for therapeutic applications. However, the deriving mechanism o...

    Authors: Chenze Xu, Ali Mohsin, Yanxia Luo, Lili Xie, Yan Peng, Qizheng Wang, Haifeng Hang, Yingping Zhuang and Meijin Guo
    Citation: Stem Cell Research & Therapy 2019 10:81
  20. Previous studies revealed that urine-derived stem cells (USCs) could promote myogenesis after the impairment of the sphincter muscles. However, the effects of exosomes secreted by USCs (USCs-Exo) were not eluc...

    Authors: Ruoyu Wu, Chengsheng Huang, Qingkai Wu, Xiang Jia, Mengyu Liu, Zhuowei Xue, Yu Qiu, Xin Niu and Yang Wang
    Citation: Stem Cell Research & Therapy 2019 10:80
  21. Mesenchymal stromal cells (MSCs) are considered potential candidates that hold great promise in the treatment of immune-related diseases. For therapeutic applications, it is necessary to isolate and expand MSC...

    Authors: Sermporn Thaweesapphithak, Chairat Tantrawatpan, Pakpoom Kheolamai, Duangrat Tantikanlayaporn, Sittiruk Roytrakul and Sirikul Manochantr
    Citation: Stem Cell Research & Therapy 2019 10:79
  22. Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation of human embryonic stem cell-derived car...

    Authors: Songyan Liao, Yuelin Zhang, Sherwin Ting, Zhe Zhen, Fan Luo, Ziyi Zhu, Yu Jiang, Sijia Sun, Wing-Hon Lai, Qizhou Lian and Hung-Fat Tse
    Citation: Stem Cell Research & Therapy 2019 10:78
  23. Numerous studies from different labs around the world report human cardiac progenitor cells (hCPCs) as having a role in myocardial repair upon ischemia/reperfusion (I/R) injury, mainly through auto/paracrine s...

    Authors: Maria J. Sebastião, Margarida Serra, Rute Pereira, Itziar Palacios, Patrícia Gomes-Alves and Paula M. Alves
    Citation: Stem Cell Research & Therapy 2019 10:77
  24. The original article [1] contains an accidental omission in the Acknowledgements.

    Authors: Fei Zhou, Shane Gao, Lin Wang, Chenxi Sun, Lu Chen, Ping Yuan, Haiyang Zhao, Yi Yi, Ying Qin, Zhiqiang Dong, Limei Cao, Haiyan Ren, Liang Zhu, Qiang Li, Bing Lu, Aibin Liang…
    Citation: Stem Cell Research & Therapy 2019 10:76

    The original article was published in Stem Cell Research & Therapy 2015 6:92

  25. Pulmonary arterial hypertension (PAH) is a rare disease characterized by widespread loss of the pulmonary microcirculation and elevated pulmonary arterial pressures leading to pathological right ventricular re...

    Authors: Colin M. Suen, Duncan J. Stewart, Joshua Montroy, Christopher Welsh, Brendan Levac, Neil Wesch, Alexander Zhai, Dean Fergusson, Lauralyn McIntyre and Manoj M. Lalu
    Citation: Stem Cell Research & Therapy 2019 10:75
  26. Low differentiation rates of mesenchymal stem cells (MSCs) limit their therapeutic effects on patients in clinical studies. Our previous study demonstrated that overexpressing p130 or E2F4 affected the multipo...

    Authors: Xiwen Zhang, Jianxiao Chen, Ming Xue, Yuying Tang, Jingyuan Xu, Ling Liu, Yingzi Huang, Yi Yang, Haibo Qiu and Fengmei Guo
    Citation: Stem Cell Research & Therapy 2019 10:74
  27. Mesenchymal stromal cells isolated from bone marrow (MSC) represent an attractive source of adult stem cells for regenerative medicine. However, thorough research is required into their clinical application sa...

    Authors: Svitlana Melnik, Nadine Werth, Stephane Boeuf, Eva-Maria Hahn, Tobias Gotterbarm, Martina Anton and Wiltrud Richter
    Citation: Stem Cell Research & Therapy 2019 10:73
  28. The body is unable to repair and regenerate large area bone defects. Moreover, the repair capacity of articular cartilage is very limited. There has long been a lack of effective treatments for osteochondral l...

    Authors: Xiaowei Wei, Baoyi Liu, Ge Liu, Fan Yang, Fang Cao, Xiaojie Dou, Weiting Yu, Benjie Wang, Guoshuang Zheng, Liangliang Cheng, Zhijie Ma, Yu Zhang, Jiahui Yang, Zihua Wang, Junlei Li, Daping Cui…
    Citation: Stem Cell Research & Therapy 2019 10:72
  29. Transplantation of mesenchymal stem cells has created enormous opportunities as a potential treatment for various diseases including neurodegenerative diseases. Given current techniques, such as Hoechst labeli...

    Authors: Nikolas Munro, Bhairavi Srinageshwar, Firas Shalabi, Maria Florendo, Paulina Otero, Cassandra Thompson, Jordyn Kippe, Clayton Malkowski, Sydney Climie, Andrew N. Stewart, Rachel Kim, Joseph Zhou, Douglas Swanson, Gary L. Dunbar, Ajit Sharma and Julien Rossignol
    Citation: Stem Cell Research & Therapy 2019 10:71
  30. The objective of this study is to determine if exuberant sympathetic nerve activity is involved in muscle satellite cell differentiation and myoblast fusion.

    Authors: Shao-juan Chen, Jing Yue, Jing-Xuan Zhang, Miao Jiang, Tu-qiang Hu, Wei-dong Leng, Li Xiang, Xin-yuan Li, Lei Zhang, Fei Zheng, Ye Yuan, Lin-yun Guo, Ya-mu Pan, Yu-wen Yan, Jia-ning Wang, Shi-You Chen…
    Citation: Stem Cell Research & Therapy 2019 10:70
  31. Multipotent mesenchymal stem cells (MSCs) have the potential to repair and regenerate damaged tissues and are considered as attractive candidates for the development of cell-based regenerative therapies. Curre...

    Authors: Benjamin Eggerschwiler, Daisy D. Canepa, Hans-Christoph Pape, Elisa A. Casanova and Paolo Cinelli
    Citation: Stem Cell Research & Therapy 2019 10:69
  32. In recent years, stem cell therapy has become a very promising and advanced scientific research topic. The development of treatment methods has evoked great expectations. This paper is a review focused on the ...

    Authors: Wojciech Zakrzewski, Maciej Dobrzyński, Maria Szymonowicz and Zbigniew Rybak
    Citation: Stem Cell Research & Therapy 2019 10:68
  33. Human bone marrow-derived mesenchymal stem cells (HBMSCs) are characterized by multiple differentiation potential and potent self-renewal ability, yet much remains to be elucidated on what determines these pro...

    Authors: Bo Jia, Zhiping Wang, Xiang Sun, Jun Chen, Jianjiang Zhao and Xiaoling Qiu
    Citation: Stem Cell Research & Therapy 2019 10:67
  34. Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease. Great efforts have been recently made to treat AD using mesenchymal stem cells (MSCs), which have immunomodulatory functions. Howeve...

    Authors: Arum Park, Hyojung Park, Jisun Yoon, Dayeon Kang, Myoung-Hee Kang, Y-Y Park, Nayoung Suh and Jinho Yu
    Citation: Stem Cell Research & Therapy 2019 10:66
  35. Functional reconstruction of maxillofacial bone defects is a considerable clinical challenge. Many studies have emphasized the osteogenic and angiopoietic abilities of stem cells for tissue regeneration. We pr...

    Authors: Chi Yang, Xiaohan Liu, Kai Zhao, Youming Zhu, Bin Hu, Yong Zhou, Mohan Wang, Yiqun Wu, Chengfei Zhang, Jianguang Xu, Yujie Ning and Duohong Zou
    Citation: Stem Cell Research & Therapy 2019 10:65
  36. BAM15 is a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced microtubule damage. The purpose of our study was to investigate...

    Authors: Mingjun Tang, Ziming Luo, Yihui Wu, Jing Zhuang, Kaijing Li, Dongpeng Hu, Huifeng Rong, Bikun Xian and Jian Ge
    Citation: Stem Cell Research & Therapy 2019 10:64
  37. Posterolateral spinal fusion with autologous bone graft is considered the “gold standard” for lumbar degenerative disc disease (DDD) when surgical treatment is indicated. The potential role of mesenchymal stro...

    Authors: Juan F. Blanco, Eva M. Villarón, David Pescador, Carmen da Casa, Victoria Gómez, Alba M. Redondo, Olga López-Villar, Miriam López-Parra, Sandra Muntión and Fermín Sánchez-Guijo
    Citation: Stem Cell Research & Therapy 2019 10:63
  38. Intrauterine adhesion (IUA) is a major cause of female secondary infertility. We previously demonstrated that menstrual blood-derived stromal cell (MenSC) transplantation helped severe IUA patients have pregna...

    Authors: Siwen Zhang, Pingping Li, Zhengwei Yuan and Jichun Tan
    Citation: Stem Cell Research & Therapy 2019 10:61
  39. Exosomes are nanoscale membrane vesicles secreted by both normal and cancer cells, and cancer cell-derived exosomes play an important role in the cross-talk between cancer c...

    Authors: Zhanjun Ma, Xue Cui, Li Lu, Guohu Chen, Yang Yang, Yan Hu, Yubao Lu, Zhangqi Cao, Yan Wang and Xuexi Wang
    Citation: Stem Cell Research & Therapy 2019 10:60

    The Retraction Note to this article has been published in Stem Cell Research & Therapy 2021 12:237

  40. The regulatory mechanism of insulin-producing cells (IPCs) differentiation from induced pluripotent stem cells (iPSCs) in vitro is very important in the phylogenetics of pancreatic islets, the molecular pathog...

    Authors: Yang Xu, Yan Huang, Yibing Guo, Yicheng Xiong, Shajun Zhu, Liancheng Xu, Jingjing Lu, Xiaohong Li, Jian Wan, Yuhua Lu and Zhiwei Wang
    Citation: Stem Cell Research & Therapy 2019 10:59
  41. Immunoregulatory capacity of mesenchymal stem cells (MSC) is triggered by the inflammatory environment, which changes during tissue repair. Macrophages are essential in mediating the inflammatory response afte...

    Authors: Laura Saldaña, Fátima Bensiamar, Gema Vallés, Francisco J. Mancebo, Eduardo García-Rey and Nuria Vilaboa
    Citation: Stem Cell Research & Therapy 2019 10:58
  42. Tissue inflammation is an important problem in the field of human adipose-derived stem cell (ASC)-based therapeutic bone regeneration. Many studies indicate that inflammatory cytokines are disadvantageous for ...

    Authors: Yuejun Wang, Yunsong Liu, Min Zhang, Longwei Lv, Xiao Zhang, Ping Zhang and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2019 10:57
  43. Mesenchymal stem/stromal cells (MSCs) delivered as cell therapy to individuals with degenerative and/or inflammatory disorders can help improve organ features and resolve inflammation, as demonstrated in precl...

    Authors: Abderrahim Naji, Benoit Favier, Frédéric Deschaseaux, Nathalie Rouas-Freiss, Masamitsu Eitoku and Narufumi Suganuma
    Citation: Stem Cell Research & Therapy 2019 10:56
  44. Despite significant progress in drug treatment, the prognosis of patients with advanced pulmonary arterial hypertension (PAH) remains extremely poor. Many preclinical studies have reported the efficacy of stem...

    Authors: Xian-Fei Ding, Huo-Yan Liang, Bo Yuan, Li-Feng Li, Tian Wang, Quan-Cheng Kan, Le-Xin Wang and Tong-Wen Sun
    Citation: Stem Cell Research & Therapy 2019 10:55
  45. Psoriasis is a chronic and systemic, immune-mediated, inflammatory disease. Mesenchymal stem cells have effects on the inflammatory microenvironment, including regulating the proliferation, differentiation, re...

    Authors: Xuping Niu, Junqing Li, Xincheng Zhao, Qiang Wang, Gang Wang, Ruixia Hou, Xinhua Li, Peng An, Guohua Yin and Kaiming Zhang
    Citation: Stem Cell Research & Therapy 2019 10:54
  46. Insulin-dependent diabetes is a multifactorial disorder that could be theoretically cured by functional pancreatic islets and insulin-producing cell (IPC) implantation. Regenerative medicine approaches include...

    Authors: Irit Meivar-Levy, Fatima Zoabi, Gil Nardini, Eugenia Manevitz-Mendelson, Gil S. Leichner, Oranit Zadok, Michael Gurevich, Eytan Mor, Simona Dima, Irinel Popescu, Aviv Barzilai, Sarah Ferber and Shoshana Greenberger
    Citation: Stem Cell Research & Therapy 2019 10:53
  47. The original article [1] contains an error in the legend of Fig 5 whereby the descriptions for panels 5d and 5e are incorrect; as such, the corrected legend can be viewed below with its respective figure images.

    Authors: Roni A. Hazim, Saravanan Karumbayaram, Mei Jiang, Anupama Dimashkie, Vanda S. Lopes, Douran Li, Barry L. Burgess, Preethi Vijayaraj, Jackelyn A. Alva-Ornelas, Jerome A. Zack, Donald B. Kohn, Brigitte N. Gomperts, April D. Pyle, William E. Lowry and David S. Williams
    Citation: Stem Cell Research & Therapy 2019 10:52

    The original article was published in Stem Cell Research & Therapy 2017 8:217

  48. Mesenchymal stem cell (MSC) encapsulation technique has long been emerged in tissue engineering as it plays an important role in implantation of stem cells to regenerate a damaged tissue. MSC encapsulation pro...

    Authors: Hyerim Kim, Chaewon Bae, Yun-Min Kook, Won-Gun Koh, Kangwon Lee and Min Hee Park
    Citation: Stem Cell Research & Therapy 2019 10:51
  49. Mesenchymal stem cells derived from the chorionic villi of human placentae (pMSCs) produce a unique array of mediators that regulate the essential cellular functions of their target cells. These properties mak...

    Authors: M. H. Abumaree, N. A. Alshehri, A. Almotery, A. M. Al Subayyil, E. Bahattab, F. M. Abomaray, T. Khatlani, B. Kalionis, D. Jawdat, M. F. El-Muzaini, M. A. Al Jumah and A. S. AlAskar
    Citation: Stem Cell Research & Therapy 2019 10:50

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