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  1. Heart failure has become a global health problem with increasing incidences worldwide. Traditional pharmacological treatments can delay but cannot reverse the underlying disease processes. The clinical applica...

    Authors: Fei Zhang, Yuan Xie and Yuhao Bian
    Citation: Stem Cell Research & Therapy 2018 9:358
    Content type: Research Published on:

  2. Methotrexate (MTX) is widely used for the treatment of rheumatoid arthritis (RA). The drug is cost-effective, but sometimes causes hepatotoxicity, requiring a physician’s attention. In this study, we simulated...

    Authors: Juryun Kim, Yena Kim, Jinhyeok Choi, Hyerin Jung, Kijun Lee, Jaewoo Kang, Narae Park, Yeri Alice Rim, Yoojun Nam and Ji Hyeon Ju
    Citation: Stem Cell Research & Therapy 2018 9:357
    Content type: Research Published on:

  3. Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) are considered attractive sources of pancreatic β cells and islet organoids. Recently, several reports presented that hESC/iPSC-deri...

    Authors: Hussain Md. Shahjalal, Ahmed Abdal Dayem, Kyung Min Lim, Tak-il Jeon and Ssang-Goo Cho
    Citation: Stem Cell Research & Therapy 2018 9:355
    Content type: Review Published on:

  4. This article [1] has been retracted by the authors because, contrary to the statement in the article, ethical approval was not obtained to conduct this study.

    Authors: Ihn Han, Miyong Yun, Eun-Ok Kim, Bonglee Kim, Min-Hyung Jung and Sung-Hoon Kim
    Citation: Stem Cell Research & Therapy 2018 9:354
    Content type: Retraction Note Published on:

    The original article was published in Stem Cell Research & Therapy 2014 5:54

  5. A 27-year-old male with HIV-associated naïve and high-risk Burkitt’s lymphoma sequentially received short-term, high-dose non-myeloablative chemotherapy and autologous CD34-positive stem cell transfusion in th...

    Authors: Haiyan Min, Jianwei Yang, Sanbin Wang, Pengfei Tao, Yuqin Song, Xiaopei Wang, Huiqin Li, Xinping Yang, Xingqi Dong, Fu-Sheng Wang, Ming Shi, Xicheng Wang and Ruonan Xu
    Citation: Stem Cell Research & Therapy 2018 9:353
    Content type: Short report Published on:

  6. Adipose tissue is an excellent source for isolation of stem cells for treating various clinical conditions including injuries to the neuromuscular system. Many previous studies have focused on differentiating ...

    Authors: R. El-Habta, M. Sloniecka, P. J. Kingham and L. J. Backman
    Citation: Stem Cell Research & Therapy 2018 9:352
    Content type: Research Published on:

  7. Human bone marrow-derived mesenchymal stem/stromal cells (hBM MSCs) have multiple functions, critical for skeletal formation and function. Their functional heterogeneity, however, represents a major challenge ...

    Authors: Alison T. Merryweather-Clarke, David Cook, Barbara Joo Lara, Peng Hua, Emmanouela Repapi, Neil Ashley, Shiang Y. Lim and Suzanne M. Watt
    Citation: Stem Cell Research & Therapy 2018 9:351
    Content type: Research Published on:

  8. Ischemic vascular diseases are the major cause of death worldwide. In recent years, endothelial cell (EC)-based approaches to vascular regeneration are increasingly viable strategies for treating ischemic dise...

    Authors: Fuyi Cheng, Yujing Zhang, Yuan Wang, Qingyuan Jiang, Cheng jian Zhao, Jie Deng, Xiaolei Chen, Yunqi Yao, Zhemin Xia, Lin Cheng, Lei Dai, Gang Shi, Yang Yang, Shuang Zhang, Dechao Yu, Yuquan Wei…
    Citation: Stem Cell Research & Therapy 2018 9:350
    Content type: Research Published on:

  9. The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation by cell reprogramming and the emerging view that ag...

    Authors: Rodolfo G. Goya, Marianne Lehmann, Priscila Chiavellini, Martina Canatelli-Mallat, Claudia B. Hereñú and Oscar A. Brown
    Citation: Stem Cell Research & Therapy 2018 9:349
    Content type: Review Published on:

  10. This study was aimed to investigate the role and specific molecular mechanism of HIF1A-AS2/miR-665/IL6 axis in regulating osteogenic differentiation of adipose-derived stem cells (ASCs) via the PI3K/Akt signal...

    Authors: Ruoyu Wu, Jihao Ruan, Yongjin Sun, Mengyu Liu, Zhuang Sha, Cunyi Fan and Qingkai Wu
    Citation: Stem Cell Research & Therapy 2018 9:348
    Content type: Research Published on:

  12. Millions of people are affected with retinal diseases that eventually cause blindness, and retinal progenitor cell (RPC) transplantation is a promising therapeutic avenue. However, RPC expansion and the underl...

    Authors: Caixia Jin, Qingjian Ou, Zongyi Li, Juan Wang, Jieping Zhang, Haibin Tian, Jing-Ying Xu, Furong Gao, Lixia Lu and Guo-Tong Xu
    Citation: Stem Cell Research & Therapy 2018 9:346
    Content type: Research Published on:

  13. Basic fibroblast growth factor (bFGF) regulates maintenance of stemness and modulation of osteo/odontogenic differentiation and mineralization in stem cells from human exfoliated deciduous teeth (SHEDs). Miner...

    Authors: Nunthawan Nowwarote, Waleerat Sukarawan, Prasit Pavasant, Brian L. Foster and Thanaphum Osathanon
    Citation: Stem Cell Research & Therapy 2018 9:345
    Content type: Research Published on:

  14. Renal ischemia–reperfusion (I/R) injury is a major cause of acute kidney injury (AKI), which is associated with high morbidity and mortality. AKI is a serious and costly medical condition. Effective therapy fo...

    Authors: Wen-Ching Shen, Yu-Hsiang Chou, Hsiang-Po Huang, Jenn-Feng Sheen, Shih-Chieh Hung and Hsin-Fu Chen
    Citation: Stem Cell Research & Therapy 2018 9:344
    Content type: Research Published on:

  15. Bone marrow-derived mesenchymal stem cells (BMSCs) are gradually getting attention because of its multi-directional differentiation potential, hematopoietic support, and promotion of stem cell implantation. Ho...

    Authors: Lihong Wang, Xianjing Han, Guojing Qu, Le Su, Baoxiang Zhao and Junying Miao
    Citation: Stem Cell Research & Therapy 2018 9:343
    Content type: Research Published on:

  16. Three-dimensional (3D) floating culture clumps of mesenchymal stem cell (MSC)/extracellular matrix (ECM) complexes (C-MSCs) consist of cells and self-produced ECM. Previous studies have demonstrated that C-MSC...

    Authors: Nao Komatsu, Mikihito Kajiya, Souta Motoike, Manabu Takewaki, Susumu Horikoshi, Tomoyuki Iwata, Kazuhisa Ouhara, Katsuhiro Takeda, Shinji Matsuda, Tsuyoshi Fujita and Hidemi Kurihara
    Citation: Stem Cell Research & Therapy 2018 9:342
    Content type: Research Published on:

  17. During differentiation of stem cells, it is recognized that molecular mechanisms of transcription factors manage stem cells towards the intended lineage. In this study, using microarray-based technology, gene ...

    Authors: Se Won Yi, Hye Jin Kim, Hyun Jyung Oh, Heejun Shin, Jung Sun Lee, Ji Sun Park and Keun-Hong Park
    Citation: Stem Cell Research & Therapy 2018 9:341
    Content type: Research Published on:

  18. Despite considerable progress in the development of methods for hematopoietic differentiation, efficient generation of transplantable hematopoietic stem cells (HSCs) and other genuine functional blood cells fr...

    Authors: Mengge Wang, Hongtao Wang, Yuqi Wen, Xiaoyuan Chen, Xin Liu, Jie Gao, Pei Su, Yuanfu Xu, Wen Zhou, Lihong Shi and Jiaxi Zhou
    Citation: Stem Cell Research & Therapy 2018 9:340
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:446

  19. Apelin plays a key beneficial role in energy metabolism by increasing glucose uptake and insulin sensitivity; however, apelin has a short half-life because it is rapidly cleared from the circulation limiting i...

    Authors: Lian Ru Gao, Ning Kun Zhang, Yan Zhang, Yu Chen, Li Wang, Ying Zhu and Hai Hong Tang
    Citation: Stem Cell Research & Therapy 2018 9:339
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:6

  20. The Wnt/β-catenin signaling pathway plays an important role in the development of second heart field (SHF Isl1+) that gives rise to the anterior heart field (AHF) cardiac progenitor cells (CPCs) for the format...

    Authors: Yong Fan, Beatrice Xuan Ho, Jeremy Kah Sheng Pang, Nicole Min Qian Pek, Jin Hui Hor, Shi-Yan Ng and Boon-Seng Soh
    Citation: Stem Cell Research & Therapy 2018 9:338
    Content type: Research Published on:

  21. As the implantation and long-term existence of tumor-specific T cells in host are the prerequisite for adoptive immunotherapy, memory stem T cells (TSCM) with self-renewal and differentiation capacity show the gr...

    Authors: Liping Guan, Xiaoyi Li, Jiali Wei, Zhihui Liang, Jing Yang, Xiufang Weng and Xiongwen Wu
    Citation: Stem Cell Research & Therapy 2018 9:337
    Content type: Research Published on:

  22. Mesenchymal stem cells (MSC) comprise a heterogeneous population of rapidly proliferating cells that can be isolated from adult (e.g., bone marrow, adipose tissue) as well as fetal (e.g., umbilical cord) tissu...

    Authors: Ioannis Christodoulou, Maria Goulielmaki, Marina Devetzi, Mihalis Panagiotidis, Georgios Koliakos and Vassilis Zoumpourlis
    Citation: Stem Cell Research & Therapy 2018 9:336
    Content type: Review Published on:

  23. Silicosis is a common occupational disease, characterized by silicotic nodules and diffuse pulmonary fibrosis. We demonstrated an anti-fibrotic effect of bone marrow mesenchymal stem cells (BMSCs) in silica-in...

    Authors: Xiaoli Li, Guoliang An, Yan Wang, Di Liang, Zhonghui Zhu and Lin Tian
    Citation: Stem Cell Research & Therapy 2018 9:335
    Content type: Research Published on:

  24. Stem cells from apical papilla (SCAP) are a subpopulation of mesenchymal stem cells (MSCs) isolated from the apical papilla of the developing tooth root apex of human teeth. Because of their osteogenic/dentino...

    Authors: Yosuke Tanaka, Soichiro Sonoda, Haruyoshi Yamaza, Sara Murata, Kento Nishida, Shion Hama, Yukari Kyumoto-Nakamura, Norihisa Uehara, Kazuaki Nonaka, Toshio Kukita and Takayoshi Yamaza
    Citation: Stem Cell Research & Therapy 2018 9:334
    Content type: Research Published on:

  26. Cell-based regenerative medicine therapies are now frequently tested in clinical trials. In many conditions, cell therapies are administered systemically, but there is little understanding of their fate, and a...

    Authors: Lauren Scarfe, Arthur Taylor, Jack Sharkey, Rachel Harwood, Michael Barrow, Joan Comenge, Lydia Beeken, Cai Astley, Ilaria Santeramo, Claire Hutchinson, Lorenzo Ressel, Jon Smythe, Eric Austin, Raphael Levy, Matthew J. Rosseinsky, Dave J. Adams…
    Citation: Stem Cell Research & Therapy 2018 9:332
    Content type: Research Published on:

  27. Bone tissue engineering is not widely used in clinical treatment. Two main reasons hide behind this: (1) the seed cells are difficult to obtain and (2) the process of tissue engineering bone construction is to...

    Authors: Dingyu Wu, Zhenxing Wang, Jinbing Wang, Yingnan Geng, Zhanzhao Zhang, Yu Li, Qiannan Li, Zhiwei Zheng, Yilin Cao and Zhi-Yong Zhang
    Citation: Stem Cell Research & Therapy 2018 9:331
    Content type: Research Published on:

  28. Menstrual blood-derived endometrial stem cells (MenSCs) emerge as an ideal source for cell-based treatment in regenerative medicine and immunotherapy. However, the major obstacle is the low survival rate in ti...

    Authors: Jiang Du, Xinxing Zhu, Rui Guo, Zhihao Xu, Fang Fang Cheng, Qing Liu, Fen Yang, Lihong Guan, Yanli Liu and Juntang Lin
    Citation: Stem Cell Research & Therapy 2018 9:330
    Content type: Research Published on:

  29. Mesenchymal stem cells (MSCs) are found in synovial fluid (SF) and can easily be harvested during arthrocentesis or arthroscopy. However, SF-MSC characterization and chondrogenicity in collagen sponges have be...

    Authors: Paul Neybecker, Christel Henrionnet, Elise Pape, Didier Mainard, Laurent Galois, Damien Loeuille, Pierre Gillet and Astrid Pinzano
    Citation: Stem Cell Research & Therapy 2018 9:329
    Content type: Research Published on:

  30. The tissue engineering of urinary bladder advances rapidly reflecting clinical need for a new kind of therapeutic solution for patients requiring urinary bladder replacement. Majority of the bladder augmentati...

    Authors: Marta Pokrywczynska, Arkadiusz Jundzill, Marta Rasmus, Jan Adamowicz, Daria Balcerczyk, Monika Buhl, Karolina Warda, Lukasz Buchholz, Maciej Gagat, Dariusz Grzanka and Tomasz Drewa
    Citation: Stem Cell Research & Therapy 2018 9:328
    Content type: Research Published on:

  31. Lung cancer stem cells have the ability to self-renew and are resistant to conventional chemotherapy. MicroRNAs (miRNAs) regulate and control the expression and function of many target genes; therefore, miRNA ...

    Authors: Xiaoyuan Wang, Qingwei Meng, Wenbo Qiao, Ruishuang Ma, Weiwei Ju, Jing Hu, Hailing Lu, Jianqi Cui, Zhao Jin, Yanbin Zhao and Yan Wang
    Citation: Stem Cell Research & Therapy 2018 9:327
    Content type: Research Published on:

  32. Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) have been shown to prevent brain damage and improve neurocognition following intraventricular hemorrhage (IVH). However, the molecular mech...

    Authors: Hyo Rim Ko, So Yoon Ahn, Yun Sil Chang, Inwoo Hwang, Taegwan Yun, Dong Kyung Sung, Se In Sung, Won Soon Park and Jee-Yin Ahn
    Citation: Stem Cell Research & Therapy 2018 9:326
    Content type: Research Published on:

  34. Regenerative medicine potentially offers the opportunity for curing male infertility. Native extracellular matrix (ECM) creates a reconstruction platform to replace the organs. In this study, we aimed to evalu...

    Authors: Elias Kargar-Abarghouei, Zahra Vojdani, Ashraf Hassanpour, Sanaz Alaee and Tahereh Talaei-Khozani
    Citation: Stem Cell Research & Therapy 2018 9:324
    Content type: Research Published on:

  35. The use of secretome may be a new strand of cell therapy, which is equal to or even superior to the injection of live cells, called cell-free therapy. In ovarian transplantation, this approach may be a therape...

    Authors: Luciana Lamarão Damous, Ana Elisa Teófilo Saturi de Carvalho, Juliana Sanajotti Nakamuta, Marcos Eiji Shiroma, Andressa Cristina Sposato Louzada, José Maria Soares-Jr, José Eduardo Krieger and Edmund C. Baracat
    Citation: Stem Cell Research & Therapy 2018 9:323
    Content type: Short report Published on:

  36. Early-stage diabetic retinopathy (DR) is characterized by neurovascular defects. In this study, we hypothesized that human adipose-derived stem cells (ASCs) positive for the pericyte marker CD140b, or their se...

    Authors: Sally L. Elshaer, William Evans, Mickey Pentecost, Raji Lenin, Ramesh Periasamy, Kumar Abhiram Jha, Shanta Alli, Jordy Gentry, Samuel M. Thomas, Nicolas Sohl and Rajashekhar Gangaraju
    Citation: Stem Cell Research & Therapy 2018 9:322
    Content type: Research Published on:

  37. Hepatocyte transplantation has been proposed as an effective treatment for patients with acute liver failure (ALF), but its application is limited by a severe shortage of donor livers. Human pluripotent stem c...

    Authors: Quan-Wen Liu, Qian-Yu Liu, Jing-Yuan Li, Li Wei, Kang-Kang Ren, Xiang-Cheng Zhang, Ting Ding, Ling Xiao, Wen-Jie Zhang, Han-You Wu and Hong-Bo Xin
    Citation: Stem Cell Research & Therapy 2018 9:321
    Content type: Research Published on:

  38. Mesenchymal stem cells (MSCs) are adult stromal cells with the capacity to differentiate into multiple types of cells. MSCs represent an attractive option in regenerative medicine due to their multifaceted abi...

    Authors: Guanguan Qiu, Guoping Zheng, Menghua Ge, Jiangmei Wang, Ruoqiong Huang, Qiang Shu and Jianguo Xu
    Citation: Stem Cell Research & Therapy 2018 9:320
    Content type: Review Published on:

  39. Better understanding of the signaling pathways that regulate human bone marrow stromal stem cell (hBMSC) differentiation into bone-forming osteoblasts is crucial for their clinical use in regenerative medicine...

    Authors: Nihal AlMuraikhi, Dalia Ali, Aliah Alshanwani, Radhakrishnan Vishnubalaji, Muthurangan Manikandan, Muhammad Atteya, Abdulaziz Siyal, Musaad Alfayez, Abdullah Aldahmash, Moustapha Kassem and Nehad M. Alajez
    Citation: Stem Cell Research & Therapy 2018 9:319
    Content type: Research article Published on:

  40. Developing cartilage constructed with the appropriate matrix composition and persistent chondrogenesis remains an enduring challenge in cartilage defects. Cartilage progenitor cell (CPC)-based tissue engineeri...

    Authors: Yahong Chen, Ke Xue, Xiaodie Zhang, Zhiwei Zheng and Kai Liu
    Citation: Stem Cell Research & Therapy 2018 9:318
    Content type: Research Published on:

  41. Spermatogonial stem cell transplantation (SSCT) could become a fertility restoration tool for childhood cancer survivors. However, since in mice, the colonization efficiency of transplanted spermatogonial stem...

    Authors: Prashant Kadam, Elissavet Ntemou, Yoni Baert, Sven Van Laere, Dorien Van Saen and Ellen Goossens
    Citation: Stem Cell Research & Therapy 2018 9:317
    Content type: Research Published on:

  42. Human muscle-derived stem cells (hMDSCs) have been shown to regenerate bone efficiently when they were transduced with Lenti-viral bone morphogenetic protein 2 (LBMP2). However, whether the age of hMDSCs and t...

    Authors: Xueqin Gao, Aiping Lu, Ying Tang, Johannes Schneppendahl, Andrea B. Liebowitz, Alex C. Scibetta, Elizabeth R. Morris, Haizi Cheng, Charles Huard, Sarah Amra, Bing Wang, Mary A. Hall, Walter R. Lowe and Johnny Huard
    Citation: Stem Cell Research & Therapy 2018 9:316
    Content type: Research Published on:

  43. Amyotrophic lateral sclerosis (ALS) represents a devastating, progressive, heterogeneous, and the most common motor neuron (MN) disease. To date, no cure has been available for the condition. Studies with tran...

    Authors: Xuejiao Sun, Jianyuan Song, Hailong Huang, Hong Chen and Kun Qian
    Citation: Stem Cell Research & Therapy 2018 9:315
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:97

  44. Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) exhibit strong and powerful potential in repairing different diseases. The expression profile of circular RNA (circRNA) provides valuable insight for re...

    Authors: Baolan Sun, Lei Shi, Qin Shi, Yao Jiang, Zhangyao Su, Xiaoqing Yang and Yuquan Zhang
    Citation: Stem Cell Research & Therapy 2018 9:314
    Content type: Research Published on:

  45. We have shown that the differentiation of human-induced pluripotent stem cells (hiPSCs) into endothelial cells (ECs) is more efficient when performed with a 3-dimensional (3D) scaffold of biomaterial than in m...

    Authors: Liping Su, Xiaocen Kong, Szeyun Lim, Szejie Loo, Shihua Tan, Kiankeong Poh, James Dutton, Colin Stewart, Stuart Cook, Xiaofei Su, Jianhua Ma, Jianyi Zhang and Lei Ye
    Citation: Stem Cell Research & Therapy 2018 9:313
    Content type: Research Published on:

  46. The aim of this study was to evaluate the safety of mesenchymal stem cell infusion in patients with autoimmune diseases.

    Authors: Jun Liang, Huayong Zhang, Wei Kong, Wei Deng, Dandan Wang, Xuebing Feng, Cheng Zhao, Bingzhu Hua, Hong Wang and Lingyun Sun
    Citation: Stem Cell Research & Therapy 2018 9:312
    Content type: Research Published on:

  47. Pulmonary fibrosis induced by silica dust is an irreversible, chronic, and fibroproliferative lung disease with no effective treatment at present. Previous studies have shown that early intervention with bone ...

    Authors: Enguo Zhang, Ye Yang, Shangya Chen, Cheng Peng, Martin F. Lavin, Abrey J. Yeo, Chao Li, Xiaoshan Liu, Yingjun Guan, Xinjing Du, Zhongjun Du and Hua Shao
    Citation: Stem Cell Research & Therapy 2018 9:311
    Content type: Research Published on:

  48. Previous studies have demonstrated remarkable tropism of mesenchymal stem cells (MSCs) toward malignant gliomas, making these cells a potential vehicle for delivery of therapeutic agents to disseminated gliobl...

    Authors: Lorena Favaro Pavon, Tatiana Tais Sibov, Andrea Vieira de Souza, Edgar Ferreira da Cruz, Suzana M. F. Malheiros, Francisco Romero Cabral, Jean Gabriel de Souza, Pamela Boufleur, Daniela Mara de Oliveira, Silvia Regina Caminada de Toledo, Luciana C. Marti, Jackeline Moraes Malheiros, Fernando F. Paiva, Alberto Tannús, Sérgio Mascarenhas de Oliveira, Ana Marisa Chudzinski-Tavassi…
    Citation: Stem Cell Research & Therapy 2018 9:310
    Content type: Research Published on:

  49. The positive effects of human bone marrow–derived mesenchymal stem cells (hBM-MSCs) and minocycline on ischemic stroke models have been well described through numerous studies. The aim of this study was to eva...

    Authors: Dong Young Cho and Sin-Soo Jeun
    Citation: Stem Cell Research & Therapy 2018 9:309
    Content type: Research Published on:

  50. The generation of hematopoietic stem cells (HSCs) and blood cells from human embryonic stem cells (hESCs) is a major goal for regenerative medicine; however, the differentiation mechanisms are largely undefine...

    Authors: Pengfei Li, Mengyao Wu, Qiwang Lin, Shu Wang, Tong Chen and Hua Jiang
    Citation: Stem Cell Research & Therapy 2018 9:301
    Content type: Research Published on:
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