Volume 4 Supplement 1

Stem cells on bioengineered microphysiological platforms for disease modeling and drug testing


Edited by Rocky S Tuan and Timothy O'Brien

Publication of this supplement has not been supported by sponsorship. Articles have undergone the journal's standard peer review process. The Editors declare that they have no competing interests.

  1. Introduction

    The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline

    The National Institutes of Health has partnered with the US Food and Drug Administration and the Defense Advanced Research Projects Agency to accelerate the development of human microphysiological systems (MPS...

    Margaret L Sutherland, Kristin M Fabre and Danilo A Tagle

    Stem Cell Research & Therapy 2013 4(Suppl 1):I1

    Published on: 20 December 2013

  2. Review

    Building additional complexity to in vitro-derived intestinal tissues

    Gastrointestinal (GI) disorders affect up to 25% of the US population. Common intestinal disorders include malabsorption, irritable bowel syndrome and fecal incontinence. Some GI disorders such as Hirschsprung...

    Samantha A Brugmann and James M Wells

    Stem Cell Research & Therapy 2013 4(Suppl 1):S1

    Published on: 20 December 2013

  3. Review

    Building a microphysiological skin model from induced pluripotent stem cells

    The discovery of induced pluripotent stem cells (iPSCs) in 2006 was a major breakthrough for regenerative medicine. The establishment of patient-specific iPSCs has created the opportunity to model diseases in ...

    Zongyou Guo, Claire A Higgins, Brian M Gillette, Munenari Itoh, Noriko Umegaki, Karl Gledhill, Samuel K Sia and Angela M Christiano

    Stem Cell Research & Therapy 2013 4(Suppl 1):S2

    Published on: 20 December 2013

  4. Review

    Human enteroids: preclinical models of non-inflammatory diarrhea

    Researchers need an available and easy-to-use model of the human intestine to better understand human intestinal physiology and pathophysiology of diseases, and to offer an enhanced platform for developing dru...

    Olga Kovbasnjuk, Nicholas C Zachos, Julie In, Jennifer Foulke-Abel, Khalil Ettayebi, Joseph M Hyser, James R Broughman, Xi-Lei Zeng, Sabine Middendorp, Hugo R de Jonge, Mary K Estes and Mark Donowitz

    Stem Cell Research & Therapy 2013 4(Suppl 1):S3

    Published on: 20 December 2013

  5. Review

    Toward a 3D model of human brain development for studying gene/environment interactions

    This project aims to establish and characterize an in vitro model of the developing human brain for the purpose of testing drugs and chemicals. To accurately assess risk, a model needs to recapitulate the complex...

    Helena T Hogberg, Joseph Bressler, Kimberly M Christian, Georgina Harris, Georgia Makri, Cliona O'Driscoll, David Pamies, Lena Smirnova, Zhexing Wen and Thomas Hartung

    Stem Cell Research & Therapy 2013 4(Suppl 1):S4

    Published on: 20 December 2013

  6. Review

    Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems

    Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointesti...

    Kira G Hartman, James D Bortner Jr, Gary W Falk, Jian Yu, Martín G Martín, Anil K Rustgi and John P Lynch

    Stem Cell Research & Therapy 2013 4(Suppl 1):S5

    Published on: 20 December 2013

  7. Review

    Three-dimensional osteochondral microtissue to model pathogenesis of osteoarthritis

    Osteoarthritis (OA), the most prevalent form of arthritis, affects up to 15% of the adult population and is principally characterized by degeneration of the articular cartilage component of the joint, often wi...

    Thomas P Lozito, Peter G Alexander, Hang Lin, Riccardo Gottardi, Anthony Wai-Ming Cheng and Rocky S Tuan

    Stem Cell Research & Therapy 2013 4(Suppl 1):S6

    Published on: 20 December 2013

  8. Review

    Microphysiological systems and low-cost microfluidic platform with analytics

    A multiorgan, functional, human in vitro assay system or 'Body-on-a-Chip' would be of tremendous benefit to the drug discovery and toxicology industries, as well as providing a more biologically accurate model fo...

    Alec ST Smith, Christopher J Long, Bonnie J Berry, Christopher McAleer, Maria Stancescu, Peter Molnar, Paula G Miller, Mandy B Esch, Jean-Matthieu Prot, James J Hickman and Michael L Shuler

    Stem Cell Research & Therapy 2013 4(Suppl 1):S9

    Published on: 20 December 2013

  9. Review

    Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing

    Microphysiological systems provide a tool to simulate normal and pathological function of organs for prolonged periods. These systems must incorporate the key functions of the individual organs and enable inte...

    George A Truskey, Hardean E Achneck, Nenad Bursac, Hon Fai Chan, Cindy S Cheng, Cristina Fernandez, Sungmin Hong, Youngmee Jung, Tim Koves, William E Kraus, Kam Leong, Lauran Madden, William M Reichert and Xuanhe Zhao

    Stem Cell Research & Therapy 2013 4(Suppl 1):S10

    Published on: 20 December 2013

  10. Review

    All-human microphysical model of metastasis therapy

    The vast majority of cancer mortalities result from distant metastases. The metastatic microenvironment provides unique protection to ectopic tumors as the primary tumors often respond to specific agents. Alth...

    Sarah E Wheeler, Jeffrey T Borenstein, Amanda M Clark, Mohammad R Ebrahimkhani, Ira J Fox, Linda Griffith, Walker Inman, Douglas Lauffenburger, Transon Nguyen, Venkateswaran C Pillai, Rachelle Prantil-Baun, Donna B Stolz, Donald Taylor, Theresa Ulrich, Raman Venkataramanan, Alan Wells…

    Stem Cell Research & Therapy 2013 4(Suppl 1):S11

    Published on: 20 December 2013

  11. Review

    A human pluripotent stem cell platform for assessing developmental neural toxicity screening

    A lack of affordable and effective testing and screening procedures mean surprisingly little is known about the health hazards of many of the tens of thousands of chemicals in use in the world today. The recen...

    Zhonggang Hou, Jue Zhang, Michael P Schwartz, Ron Stewart, C David Page, William L Murphy and James A Thomson

    Stem Cell Research & Therapy 2013 4(Suppl 1):S12

    Published on: 20 December 2013

  12. Review

    Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development

    Drug discovery and development to date has relied on animal models, which are useful but are often expensive, slow, and fail to mimic human physiology. The discovery of human induced pluripotent stem (iPS) cel...

    Anurag Mathur, Peter Loskill, SoonGweon Hong, Jae Young Lee, Sivan G Marcus, Laure Dumont, Bruce R Conklin, Holger Willenbring, Luke P Lee and Kevin E Healy

    Stem Cell Research & Therapy 2013 4(Suppl 1):S14

    Published on: 20 December 2013

  13. Review

    An integrated in vitro model of perfused tumor and cardiac tissue

    Cancer and cardiovascular disease remain the two leading causes of death in the United States. Progress in treatment to reduce morbidity and mortality will include the development of new drugs. Recent advances...

    Monica Moya, David Tran and Steven C George

    Stem Cell Research & Therapy 2013 4(Suppl 1):S15

    Published on: 20 December 2013

  14. Review

    Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans

    Although the process of drug development requires efficacy and toxicity testing in animals prior to human testing, animal models have limited ability to accurately predict human responses to xenobiotics and ot...

    Abhinav Bhushan, Nina Senutovitch, Shyam S Bale, William J McCarty, Manjunath Hegde, Rohit Jindal, Inna Golberg, O Berk Usta, Martin L Yarmush, Lawrence Vernetti, Albert Gough, Ahmet Bakan, Tong Ying Shun, Richard Biasio and D Lansing Taylor

    Stem Cell Research & Therapy 2013 4(Suppl 1):S16

    Published on: 20 December 2013

  15. Review

    Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system

    Kidney disease is a public health problem that affects more than 20 million people in the US adult population, yet little is understood about the impact of kidney disease on drug disposition. Consequently ther...

    Edward J Kelly, Zhican Wang, Jenna L Voellinger, Cathy K Yeung, Danny D Shen, Kenneth E Thummel, Ying Zheng, Giovanni Ligresti, David L Eaton, Kimberly A Muczynski, Jeremy S Duffield, Thomas Neumann, Anna Tourovskaia, Mark Fauver, Greg Kramer, Elizabeth Asp…

    Stem Cell Research & Therapy 2013 4(Suppl 1):S17

    Published on: 20 December 2013

  16. Review

    Neurovascular unit on a chip: implications for translational applications

    The blood-brain barrier (BBB) dynamically controls exchange between the brain and the body, but this interaction cannot be studied directly in the intact human brain or sufficiently represented by animal model...

    Donald J Alcendor, Frank E Block III, David E Cliffel, John Scott Daniels, Kate LJ Ellacott, Cody R Goodwin, Lucas H Hofmeister, Deyu Li, Dmitry A Markov, Jody C May, Lisa J McCawley, BethAnn McLaughlin, John A McLean, Kevin D Niswender, Virginia Pensabene, Kevin T Seale…

    Stem Cell Research & Therapy 2013 4(Suppl 1):S18

    Published on: 20 December 2013