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  1. Acute kidney injury (AKI) is a complex disease and can be generally divided into prerenal, intrarenal, and postrenal AKI (PR-AKI). Previous studies have shown that mesenchymal stem cells (MSCs)-derived extrace...

    Authors: Weihui Li, Wei Wang, Xin He, Zheng Liao, Aili Aierken, Jinlian Hua, Yan Wang, Dezhang Lu and Shiqiang Zhang
    Citation: Stem Cell Research & Therapy 2022 13:379
    Content type: Research Published on:

  2. Stroke is the leading cause of disability worldwide, resulting in severe damage to the central nervous system and disrupting neurological functions. There is no effective therapy for promoting neurological rec...

    Authors: Yi-Chao Ye, Zhe-Han Chang, Peng Wang, You-Wei Wang, Jun Liang, Chong Chen, Jing-Jing Wang, Hong-Tao Sun, Yi Wang and Xiao-Hong Li
    Citation: Stem Cell Research & Therapy 2022 13:378
    Content type: Research Published on:

  3. Breast cancer is the most common malignancy in women worldwide, and its treatment largely depends on mastectomy. Patients after mastectomy suffer from crippled body image, self-esteem, and quality of life. Pos...

    Authors: Xueqin Dai, Xinye Wang, Chuanyu Yang, Maobo Huang, Zhongmei Zhou, Ying Qu, Xiaojiang Cui, Rong Liu and Ceshi Chen
    Citation: Stem Cell Research & Therapy 2022 13:377
    Content type: Research Published on:

  4. All-trans retinoic acid (ATRA) plays an essential role during human eye development, being temporally and spatially adjusted to create gradient concentrations that guide embryonic anterior and posterior axis f...

    Authors: Helena Isla-Magrané, Maddalen Zufiaurre-Seijo, José García-Arumí and Anna Duarri
    Citation: Stem Cell Research & Therapy 2022 13:376
    Content type: Short report Published on:

  5. Renal tubular epithelial–myofibroblast transdifferentiation (EMT) plays a key role in the regulation of renal fibrosis. Exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs) play a crucia...

    Authors: Zhenhua Qiu, Zhihui Zhong, Yuehan Zhang, Haoling Tan, Bo Deng and Guohuang Meng
    Citation: Stem Cell Research & Therapy 2022 13:373
    Content type: Research Published on:

  6. Hair follicle mesenchymal stem cells (HF-MSCs) have great potential for cell therapy. Traditional method to isolate whisker HF-MSC is time-consuming and few in cell numbers. How to quickly and conveniently obt...

    Authors: Yuyang Gan, Hailin Wang, Lijuan Du, Zhexiang Fan, Pingping Sun, Kaitao Li, Qian Qu, Jin Wang, Ruosi Chen, Zhiqi Hu and Yong Miao
    Citation: Stem Cell Research & Therapy 2022 13:372
    Content type: Research Published on:

  7. Parkinson's disease (PD) is the second most predominant neurodegenerative disease worldwide. It is recognized clinically by severe complications in motor function caused by progressive degeneration of dopamine...

    Authors: Reza Mosaddeghi Heris, Milad Shirvaliloo, Sanaz Abbaspour-Aghdam, Ali Hazrati, Ali Shariati, Hamed Rahmani Youshanlouei, Farhad Jadidi Niaragh, Hamed Valizadeh and Majid Ahmadi
    Citation: Stem Cell Research & Therapy 2022 13:371
    Content type: Review Published on:

  8. Islet transplantation is an excellent method for the treatment of type I diabetes mellitus. However, due to the limited number of donors, cumbersome isolation and purification procedures, and immune rejection,...

    Authors: Pengxiu Dai, Guixiang Qi, Haojie Xu, Mingde Zhu, Jiakai Li, Yijing Chen, Luwen Zhang, Xinke Zhang and Yihua Zhang
    Citation: Stem Cell Research & Therapy 2022 13:370
    Content type: Research Published on:

  9. RUNX1T1 (Runt-related transcription factor 1, translocated to 1), a myeloid translocation gene (MTG) family member, is usually investigated as part of the fusion protein RUNX1-RUNX1T1 for its role in acute mye...

    Authors: Nan Hu, Linqing Zou, Cheng Wang and Guoqi Song
    Citation: Stem Cell Research & Therapy 2022 13:369
    Content type: Review Published on:

  10. Salivary glands produce saliva that play essential roles in digestion and oral health. Derivation of salivary gland organoids from pluripotent stem cells (PSCs) provides a powerful platform to model the organo...

    Authors: Siqi Zhang, Yi Sui, Shuang Yan, Yifei Zhang, Chong Ding, Xiaodong Su, Jingwei Xiong and Shicheng Wei
    Citation: Stem Cell Research & Therapy 2022 13:368
    Content type: Research Published on:

  11. Ischemia–reperfusion injury (IRI)-induced acute kidney injury (AKI) can repair itself completely. However, most moderate and severe patients undergoing IRI-AKI progress to chronic kidney disease due to incompl...

    Authors: Xiangcheng Xie, Xiu Yang, Junxia Wu, Shengjie Tang, LiLi Yang, Xiao Fei and Ming Wang
    Citation: Stem Cell Research & Therapy 2022 13:367
    Content type: Research Published on:

  12. The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide consideration because of their immense potential for immunomodulation and their therapeutic function in tissue regeneration. MS...

    Authors: Ria Margiana, Alexander Markov, Angelina O. Zekiy, Mohammed Ubaid Hamza, Khalid A. Al-Dabbagh, Sura Hasan Al-Zubaidi, Noora M. Hameed, Irshad Ahmad, R. Sivaraman, Hamzah H. Kzar, Moaed E. Al-Gazally, Yasser Fakri Mustafa and Homayoon Siahmansouri
    Citation: Stem Cell Research & Therapy 2022 13:366
    Content type: Review Published on:

  13. High morbidity and mortality rates of the COVID-19 pandemic have made it a global health priority. Acute respiratory distress syndrome (ARDS) is one of the most important causes of death in COVID-19 patients. ...

    Authors: Hamid Reza Aghayan, Fatemeh Salimian, Atefeh Abedini, Samrand Fattah Ghazi, Masud Yunesian, Sepideh Alavi-Moghadam, Jalil Makarem, Keivan Majidzadeh-A, Ali Hatamkhani, Maryam Moghri, Abbas Danesh, Mohammad Reza Haddad-Marandi, Hassan Sanati, Fereshteh Abbasvandi, Babak Arjmand, Pourya Azimi…
    Citation: Stem Cell Research & Therapy 2022 13:365
    Content type: Research Published on:

  17. Authors: Bo-Feng Yin, Zhi-Ling Li, Zi-Qiao Yan, Zheng Guo, Jia-Wu Liang, Qian Wang, Zhi-Dong Zhao, Pei-Lin Li, Rui-Cong Hao, Meng-Yue Han, Xiao-Tong Li, Ning Mao, Li Ding, Da-Fu Chen, Yue Gao and Heng Zhu
    Citation: Stem Cell Research & Therapy 2022 13:361
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2022 13:241

  19. Osteoporosis affects the mandible resulting in bone loss. Though impairments are not life threatening, they affect a person's quality-of-life particularly vulnerable elderly. MicroRNAs (miRNAs) are novel regul...

    Authors: Shaoming Li, Ling Gao, Weidong Zhang, Yanbin Yu, Jingjing Zheng, Xiao Liang, Shanshan Xin, Wenhao Ren and Keqian Zhi
    Citation: Stem Cell Research & Therapy 2022 13:359
    Content type: Research Published on:

  20. Human mesenchymal stromal cells (MSCs) have immunomodulatory, anti-inflammatory, and tolerogenic effects. Long-term in vitro expansion of MSCs to generate clinical grade products results in the accumulation of...

    Authors: Rose Triantafillia Psaroudis, Urvashi Singh, Maximilien Lora, Peter Jeon, Abigail Boursiquot, Ursula Stochaj, David Langlais and Inés Colmegna
    Citation: Stem Cell Research & Therapy 2022 13:358
    Content type: Research Published on:

  21. Adipose tissue inflammation is considered as one of the major mechanisms underlying the pathogenesis of insulin resistance and complications in diabetes. Here, we aimed to study the effects of adipose-derived ...

    Authors: Lee-Wei Chen, Pei-Hsuan Chen, Chia-Hua Tang and Jui-Hung Yen
    Citation: Stem Cell Research & Therapy 2022 13:357
    Content type: Research Published on:

  23. In diabetic kidney disease, high glucose damages specialized cells called podocytes that filter blood in the glomerulus. In vitro culture of podocytes is crucial for modeling of diabetic nephropathy and geneti...

    Authors: Julie Bejoy, Justin M. Farry, Jennifer L. Peek, Mariana C. Cabatu, Felisha M. Williams, Richard C. Welch, Eddie S. Qian and Lauren E. Woodard
    Citation: Stem Cell Research & Therapy 2022 13:355
    Content type: Research Published on:

  24. Mesenchymal stem cells (MSCs) are considered to be a potential therapeutic tool for liver fibrosis. Inhibiting the activation of hepatic stellate cells (HSCs) and protecting hepatocytes are important mechanism...

    Authors: Qing Zhou, Chao Rong, Tengfei Gu, Hongda Li, Lei Wu, Xuemei Zhuansun, Xin Zhao, Zuorun Xiao, Yuting Kuang, Sanrong Xu and Shouli Wang
    Citation: Stem Cell Research & Therapy 2022 13:354
    Content type: Research Published on:

  25. Hemophilia B is a rare inherited genetic bleeding disorder caused by a deficiency or lack of coagulation factor IX, the gene for which (F9) is located on the X chromosome. Hemophilia B is currently incurable and ...

    Authors: Yanchun Ma, Wenwen Sun, Lidong Zhao, Mingze Yao, Changxin Wu, Pengfei Su, Linhua Yang and Gang Wang
    Citation: Stem Cell Research & Therapy 2022 13:353
    Content type: Research Published on:

  26. In our previous research, we found that overexpression of miR-126-3p in human umbilical cord MSCs (hucMSCs) promoted human umbilical vein endothelial cells angiogenic activities through exosome-mediated mechan...

    Authors: Qingxi Qu, Linghong Liu, Yuqian Cui, Hongli Liu, Jingyang Yi, Weidong Bing, Chunxiao Liu, Detian Jiang and Yanwen Bi
    Citation: Stem Cell Research & Therapy 2022 13:352
    Content type: Research Published on:

  27. Stem cell niche maintains stem cell population identity and is essential for the homeostasis of self-renewal and differentiation in Drosophila testes. However, the mechanisms of CySC lineage signals-mediated soma...

    Authors: Zhiran Li, Yunhao Wu, Yangbo Fu, Xia Chen, Xi Zhao, Xiaolong Wu, Yajuan Lu, Hui He, Cong Shen, Bo Zheng, Jun Yu and Fei Sun
    Citation: Stem Cell Research & Therapy 2022 13:351
    Content type: Research Published on:

  28. The purpose of this study was to investigate allogenic immune responses following the transplantation of insulin-producing cells (IPCs) differentiated from human adipose tissue-derived stem cells (hAT-MSCs) in...

    Authors: Mohamed A. Ghoneim, Mahmoud M. Gabr, Ayman F. Refaie, Sawsan M. El-Halawani, Mohga M. Al-issawi, Batoul L. Elbassiouny, Mai A. Abd El Kader, Amani M. Ismail, Mona F. Zidan, Mary S. Karras, Raghda W. Magar, Sherry M. Khater, Sylvia A. Ashamallah, Mahmoud M. Zakaria and Malgorzata Kloc
    Citation: Stem Cell Research & Therapy 2022 13:350
    Content type: Research Published on:

  29. Preclinical studies have suggested that adipose-derived mesenchymal stem cells (ADSCs) transplantation can suppress abdominal aortic inflammation and aneurysm expansion through paracrine factors. Yet, the mech...

    Authors: Jiateng Hu, Yihong Jiang, Xiaoyu Wu, Zhaoyu Wu, Jinbao Qin, Zhen Zhao, Bo Li, Zhijue Xu, Xinwu Lu, Xin Wang and Xiaobing Liu
    Citation: Stem Cell Research & Therapy 2022 13:349
    Content type: Research Published on:

  30. Bone marrow mesenchymal stromal cells (BM-MSCs) have anti-inflammatory and pro-survival properties. Naturally, they do not express human leukocyte antigen class II surface antigens and have immunosuppressive c...

    Authors: Zahra Azizi, Roya Abbaszadeh, Roxana Sahebnasagh, Amir Norouzy, Elahe Motevaseli and Kathrin Maedler
    Citation: Stem Cell Research & Therapy 2022 13:348
    Content type: Review Published on:

  31. Emerging drug-free in vitro activation (IVA) technique enables patients with premature ovarian insufficiency (POI) to restore ovarian function and conceive their own genetic offspring. However, various issues ...

    Authors: Qian Li, Jiahua Zheng, Zhongkang Li, Yanlai Xiao, Mingle Zhang, Wenxin Shi, He Gao, Xianghua Huang and Jingkun Zhang
    Citation: Stem Cell Research & Therapy 2022 13:347
    Content type: Research Published on:

  32. Cryostorage of spermatogonial stem cells (SSCs) is an appropriate procedure for long-term storage of SSCs for fertility preservation. However, it causes damage to cellular structures through overproduction of ...

    Authors: Shokoofeh Kazemzadeh, Shahram Mohammadpour, Soheila Madadi, Azar Babakhani, Maryam Shabani and Maryam Khanehzad
    Citation: Stem Cell Research & Therapy 2022 13:346
    Content type: Research Published on:

  33. Peripheral arterial disease is atherosclerotic occlusive disease of the lower extremity arteries and afflicts hundreds of millions of individuals worldwide. Its most severe manifestation is chronic limb-threat...

    Authors: Laura V. Lozano Navarro, Xueyi Chen, Lady Tatiana Giratá Viviescas, Andrea K. Ardila-Roa, Maria L. Luna-Gonzalez, Claudia L. Sossa and Martha L. Arango-Rodríguez
    Citation: Stem Cell Research & Therapy 2022 13:345
    Content type: Review Published on:

  34. Mesenchymal-based therapy has been utilized as a practical approach in the treatment of renal ischemia/reperfusion (I/R) injury. However, low cell retention and survival in the ischemic site have remained chal...

    Authors: Haniyeh Najafi, Samira Sadat Abolmaali, Reza Heidari, Hadi Valizadeh, Ali Mohammad Tamaddon and Negar Azarpira
    Citation: Stem Cell Research & Therapy 2022 13:344
    Content type: Research Published on:

  35. Impairment in neurogenesis correlates with memory and  cognitive dysfunction in AD patients. In the recent decade, therapies with stem cell bases are growing and proved to be efficient. This study is a prelimi...

    Authors: Gozal Bahlakeh, Reza Rahbarghazi, Ali Abedelahi, Saeed Sadigh-Eteghad and Mohammad Karimipour
    Citation: Stem Cell Research & Therapy 2022 13:343
    Content type: Research Published on:

  36. The imbalance of osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is closely related to steroid-induced avascular necrosis of the femoral head (SANFH). We aimed to investigat...

    Authors: Ping Duan, Hanyu Wang, Xinzeyu Yi, Hao Zhang, Hui Chen and Zhenyu Pan
    Citation: Stem Cell Research & Therapy 2022 13:342
    Content type: Research Published on:

  37. Traumatic brain injury (TBI) leads to cell and tissue impairment, as well as functional deficits. Stem cells promote structural and functional recovery and thus are considered as a promising therapy for variou...

    Authors: Qiaozhen Qin, Ting Wang, Zhenhua Xu, Shuirong Liu, Heyang Zhang, Zhangzhen Du, Jianing Wang, Yadi Wang, Zhenning Wang, Shanshan Yuan, Jiamei Wu, Wenyan He, Changzhen Wang, Xinlong Yan, Yan Wang and Xiaoxia Jiang
    Citation: Stem Cell Research & Therapy 2022 13:341
    Content type: Research Published on:

  38. Nucleus pulposus mesenchymal stem cells (NPMSCs) transplantation is a promising treatment for intervertebral disc degeneration (IVDD). However, the transplanted NPMSCs exhibited weak cell proliferation, high c...

    Authors: Yu-yao Zhang, Zhi-lei Hu, Yu-han Qi, Hai-yin Li, Xian Chang, Xiao-xin Gao, Chen-hao Liu, Yue-yang Li, Jin-hui Lou, Yu Zhai and Chang-qing Li
    Citation: Stem Cell Research & Therapy 2022 13:340
    Content type: Research Published on:

  39. The differentiation of human induced pluripotent stem cells (iPSCs) into oocytes, which involves the transformation from mitosis to meiosis, has been a hotspot of biological research for many years and represe...

    Authors: Sheng Yang, Zhen Liu, Shengda Wu, Lang Zou, Yanpei Cao, Hongjia Xu, Jingfeng Huang, Qingyan Tian, Fanggui Wu, Panpan Li, Shuping Peng and Cijun Shuai
    Citation: Stem Cell Research & Therapy 2022 13:339
    Content type: Research Published on:

  40. Authors: Charlotte Sarre, Rafael Contreras-Lopez, Nitirut Nernpermpisooth, Christian Barrere, Sarah Bahraoui, Claudia Terraza, Gautier Tejedor, Anne Vincent, Patricia Luz-Crawford, Kantapich Kongpol, Sarawut Kumphune, Christophe Piot, Joel Nargeot, Christian Jorgensen, Farida Djouad and Stéphanie Barrere-Lemaire
    Citation: Stem Cell Research & Therapy 2022 13:338
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2022 13:167

  41. Organoids are 3D structures grown from pluripotent stem cells derived from human tissue and serve as in vitro miniature models of human organs. Organoids are expected to revolutionize biomedical research and c...

    Authors: Dide de Jongh, Emma K. Massey and Eline M. Bunnik
    Citation: Stem Cell Research & Therapy 2022 13:337
    Content type: Review Published on:

  42. Diabetic foot ulcer (DFU) is a chronic infectious disease caused by diabetes mellitus (DM). Angiogenesis plays the decisive role in wound healing of DFU. Adipose-derived stem cells (ADSCs) can ameliorate angio...

    Authors: Zun-Hong Liang, Nan-Fang Pan, Shi-Shuai Lin, Zhi-Yang Qiu, Ping Liang, Jun Wang, Zhi Zhang and Yun-Chuan Pan
    Citation: Stem Cell Research & Therapy 2022 13:336
    Content type: Research Published on:

  43. There is increasing evidence that mesenchymal stem cells (MSCs) help shape the tumor microenvironment and promote tumor progression, and ion channels might play a critical role in this process. The objective o...

    Authors: Chunling Xue, Yang Gao, Xuechun Li, Mingjia Zhang, Ying Yang, Qin Han, Zhao Sun, Chunmei Bai and Robert Chunhua Zhao
    Citation: Stem Cell Research & Therapy 2022 13:335
    Content type: Research Published on:

  44. Acne is a chronic facial disease caused by Propionibacterium acnes, which proliferates within sebum-blocked skin follicles and increases inflammatory cytokine production. Several therapeutic drugs and products ha...

    Authors: Xiaoxi Li, Sai Luo, Xinyao Chen, Shasha Li, Lijun Hao and Dan Yang
    Citation: Stem Cell Research & Therapy 2022 13:334
    Content type: Research Published on:

  45. Mesenchymal stromal cells (MSCs) activated with IFN-γ elicit stronger physical effects. Exosomes (Exos) secreted from MSCs show protective effects against myocardial injury. This study aimed to determine wheth...

    Authors: Jian Zhang, Yao Lu, Yangming Mao, Yue Yu, Tianyu Wu, Wei Zhao, Yeqian Zhu, Pengcheng Zhao and Fengxiang Zhang
    Citation: Stem Cell Research & Therapy 2022 13:333
    Content type: Research Published on:

  46. Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have emerged as a powerful tool for disease modeling, though their immature nature currently limits translation into clinical practice. Maturatio...

    Authors: Sofija Vučković, Rafeeh Dinani, Edgar E. Nollet, Diederik W. D. Kuster, Jan Willem Buikema, Riekelt H. Houtkooper, Miranda Nabben, Jolanda van der Velden and Birgit Goversen
    Citation: Stem Cell Research & Therapy 2022 13:332
    Content type: Review Published on:

  47. Due to the large area and deep width of the artificial neovagina after vaginoplasty, it takes a considerable amount of time to achieve complete epithelization of the neovagina. Currently, the clinical therapie...

    Authors: Yiyun Xu, Yu Qiu, Qiuning Lin, Chengsheng Huang, Jie Li, Liqi Chen, Zhuowei Xue, Qingkai Wu and Yang Wang
    Citation: Stem Cell Research & Therapy 2022 13:331
    Content type: Research Published on:

  48. Despite emerging evidence on the therapeutic potential of mesenchymal stem cells (MSCs) for liver fibrosis, the underlying mechanisms remain unclear. At present, MSC-derived exosomes (MSC-EXOs) are widely acce...

    Authors: Siyuan Tian, Xia Zhou, Miao Zhang, Lina Cui, Bo Li, Yansheng Liu, Rui Su, Keshuai Sun, Yinan Hu, Fangfang Yang, Guoyun Xuan, Shuoyi Ma, Xiaohong Zheng, Xinmin Zhou, Changcun Guo, Yulong Shang…
    Citation: Stem Cell Research & Therapy 2022 13:330
    Content type: Research Published on:

  49. Flap transplantation is commonly used in reconstructive surgery. A prerequisite for skin flap survival is sufficient blood supply. However, such approaches remain unclear. This study aimed to explore the under...

    Authors: Linlin Guo, Yuxuan Chen, Xiaoling Feng, Di Sun, Jiaming Sun, Shan Mou, Kangcheng Zhao and Ran An
    Citation: Stem Cell Research & Therapy 2022 13:325
    Content type: Research Published on:

  50. The source of SAN is debated among researchers. Many studies have shown that RA and Wnt signaling are involved in heart development. In this study, we investigated the role of retinoic acid (RA) and Wnt signal...

    Authors: Lin Yin, Feng-yuan Wang, Wei Zhang, Xi Wang, Yan-hong Tang, Teng Wang, Yu-ting Chen and Cong-xin Huang
    Citation: Stem Cell Research & Therapy 2022 13:324
    Content type: Research Published on:
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