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  1. Large area skin trauma has always been a great challenge for both patients and clinicians. Exosomes originating from human adipose-derived mesenchymal stem cells (hADSCs) have been a novel promising cell-free ...

    Authors: Yang Zhou, Xing-Liao Zhang, Shou-Tao Lu, Ning-Yan Zhang, Hai-Jun Zhang, Jing Zhang and Jun Zhang
    Citation: Stem Cell Research & Therapy 2022 13:407
    Content type: Research Published on:

  2. The therapeutic potential of mesenchymal stem cells (MSCs) in type 1 diabetes (T1D) has been demonstrated in both preclinical and clinical studies. MSCs that have been used in research on T1D are derived from ...

    Authors: Wei Zhang, Qing Ling, Bin Wang, Kai Wang, Jianbo Pang, Jing Lu, Yan Bi and Dalong Zhu
    Citation: Stem Cell Research & Therapy 2022 13:406
    Content type: Research Published on:

  3. During aging, perturbation of muscle progenitor cell (MPC) constituents leads to progressive loss of muscle mass and accumulation of adipose and fibrotic tissue. Mesenchymal stem cells (MSCs) give rise to adip...

    Authors: Aiping Lu, Chieh Tseng, Ping Guo, Zhanguo Gao, Kaitlyn E. Whitney, Mikhail G. Kolonin and Johnny Huard
    Citation: Stem Cell Research & Therapy 2022 13:405
    Content type: Research Published on:

  4. Smokers directly inhale mainstream cigarette smoke, which contains numerous known and potential toxic substances, and thus, smoking is expected to have broad harmful effects that cause tissue injury and dysfun...

    Authors: Se-Ra Park, Seong-Kwan Kim, Soo-Rim Kim, Wook-Joon Yu, Seung-Jin Lee and Hwa-Yong Lee
    Citation: Stem Cell Research & Therapy 2022 13:404
    Content type: Research Published on:

  5. Mesenchymal stem cell (MSC) therapy has been shown to be a promising option for liver fibrosis treatment. However, critical factors affecting the efficacy of MSC therapy for liver fibrosis remain unknown. Foll...

    Authors: Xiaohong Zheng, Xia Zhou, Gang Ma, Jiahao Yu, Miao Zhang, Chunmei Yang, Yinan Hu, Shuoyi Ma, Zheyi Han, Wen Ning, Boquan Jin, Xinmin Zhou, Jingbo Wang and Ying Han
    Citation: Stem Cell Research & Therapy 2022 13:403
    Content type: Research Published on:

  7. The basis of orthodontic tooth movement (OTM) is the reconstruction of periodontal tissue under stress. Increasing the speed of OTM has always been the focus of attention.

    Authors: Li Wang, Hong Liang, Bingjing Sun, Jing Mi, Xianqin Tong, Yuhui Wang, Meihua Chen, Liming Yu, Jie Pan, Shangfeng Liu, Yan-Jun Liu and Yuehua Liu
    Citation: Stem Cell Research & Therapy 2022 13:401
    Content type: Research Published on:

  8. Traumatic impacts to the articular joint surface are known to lead to cartilage degeneration, as in post-traumatic osteoarthritis (PTOA). Limited progress in the development of disease-modifying OA drugs (DMOA...

    Authors: Chunrong He, Karen L. Clark, Jian Tan, Hecheng Zhou, Rocky S. Tuan, Hang Lin, Song Wu and Peter G. Alexander
    Citation: Stem Cell Research & Therapy 2022 13:400
    Content type: Research Published on:

  9. Premature ovarian insufficiency (POI) is the main cause of female infertility. Adipose-derived stem cells (ADSCs) are ideal candidates for the treatment of POI. However, some deficient biological characteristi...

    Authors: Qiao-yi Huang, Shao-rong Chen, Yun-xia Zhao, Jia-ming Chen, Wei-hong Chen, Shu Lin and Qi-yang Shi
    Citation: Stem Cell Research & Therapy 2022 13:399
    Content type: Research Published on:

  11. Diabetes-related osteoporosis (DOP) is a chronic disease caused by the high glucose environment that induces a metabolic disorder of osteocytes and osteoblast-associated mesenchymal stem cells. The processes o...

    Authors: Maorui Zhang, Yujin Gao, Qing Li, Huayue Cao, Jianghua Yang, Xiaoxiao Cai and Jingang Xiao
    Citation: Stem Cell Research & Therapy 2022 13:397
    Content type: Research Published on:

  13. In diabetes, delayed wound healing was considered as the result of excessive recruitment and retention of pro-inflammatory cells and factors. Hematopoietic prostaglandin D synthase (HPGDS) was identified from ...

    Authors: Long Ouyang, Daojing Qiu, Xin Fu, Aiping Wu, Pengyuan Yang, Zhigang Yang, Qian Wang, Li Yan and Ran Xiao
    Citation: Stem Cell Research & Therapy 2022 13:395
    Content type: Research Published on:

  14. Retinitis pigmentosa is a rod-cone degenerative disease that induces irreversible vision loss. This study probed the protective capacity of mesenchymal stem cell-derived small EVs (MSC-EVs) on the retinas of r...

    Authors: Jia Zhang, Pengdong Li, Guifang Zhao, Siqi He, Di Xu, Weijie Jiang, Qian Peng, Zhaohui Li, Zhongjian Xie, Han Zhang, Ying Xu and Ling Qi
    Citation: Stem Cell Research & Therapy 2022 13:394
    Content type: Research Published on:

  15. Psoriasis is a chronic inflammatory skin disease. Tissue stem cells have exhibited a therapeutic effect on psoriatic mice. However, the therapeutic effect of topical administration of the secretome derived fro...

    Authors: Mengbo Yang, Lanqi Wang, Zhimin Chen, Weijie Hao, Qian You, Jianhua Lin, Jingzhi Tang, Xin Zhao, Wei-Qiang Gao and Huiming Xu
    Citation: Stem Cell Research & Therapy 2022 13:393
    Content type: Research Published on:

  16. Human mesenchymal stem cells (hMSCs) have been proven to have inherent chondrogenic differentiation potential, which appears to be used in cartilage regeneration. Increasing evidence suggests that irisin enhan...

    Authors: Taiqiu Chen, Yan Peng, Wenjun Hu, Huihong Shi, Pengfei Li, Yichen Que, Jincheng Qiu, Xianjian Qiu, Bo Gao, Hang Zhou, Yanbo Chen, Yuanxin Zhu, Shaoguang Li, Anjing Liang, Wenjie Gao and Dongsheng Huang
    Citation: Stem Cell Research & Therapy 2022 13:392
    Content type: Research Published on:

  17. Mesenchymal stem cells (MSCs) have a great potential ability for endothelial differentiation, contributing to an effective means of therapeutic angiogenesis. Placenta-derived mesenchymal stem cells (PMSCs) hav...

    Authors: Yang Zhang, Yanqi Zhong, Weifang Liu, Fanghui Zheng, Yin Zhao, Li Zou and Xiaoxia Liu
    Citation: Stem Cell Research & Therapy 2022 13:391
    Content type: Research Published on:

  18. Peyronie’s disease (PD) is a fibrotic disorder of the penis, but effective treatments are lacking. Here, we observed the effects of rat-derived bone marrow mesenchymal stem cells (BMSCs) injection in the activ...

    Authors: Wenting Wang, Weifang Ding, Xuebao Zhang, Shuang Wu, Tianxi Yu, Xin Cui, Yaqi Xie, Diandong Yang and Chunhua Lin
    Citation: Stem Cell Research & Therapy 2022 13:390
    Content type: Research Published on:

  19. Induced pluripotent stem cells (iPSCs) have the potential to promote wound healing; however, their adhesion to the extracellular matrix (ECM) might decrease iPSC migration, thereby limiting their therapeutic p...

    Authors: Yansong Ren, Jinbo Liu, Huijun Xu, Shun Wang, Shirui Li, Meng Xiang and Sifeng Chen
    Citation: Stem Cell Research & Therapy 2022 13:389
    Content type: Research Published on:

  20. Diabetic retinopathy, a major complication of diabetes mellitus, is a leading cause of sigh-loss in working age adults. Progressive loss of integrity of the retinal neurovascular unit is a central element in t...

    Authors: Judith Lechner, Reinhold J. Medina, Noemi Lois and Alan W. Stitt
    Citation: Stem Cell Research & Therapy 2022 13:388
    Content type: Review Published on:

  21. Chronic kidney disease (CKD) is a worldwide health problem that its incidence increases nowadays with the increase in the risk of environmental pollution. CKD can progress to end-stage renal disease (ESRD) whi...

    Authors: Hala M. F. El Miniawy, Haithem A. Farghali, Marwa S. Khattab, Ibrahim A. Emam, Essam M. Ibrahem, Dina Sabry and Tahany A. Ismail
    Citation: Stem Cell Research & Therapy 2022 13:387
    Content type: Research Published on:

  22. Seeding cells are key factors in cell-based cartilage tissue regeneration. Monoculture of either chondrocyte or mesenchymal stem cells has several limitations. In recent years, co-culture strategies have provi...

    Authors: Kaiwen Zheng, Yiyang Ma, Cheng Chiu, Yidan Pang, Junjie Gao, Changqing Zhang and Dajiang Du
    Citation: Stem Cell Research & Therapy 2022 13:386
    Content type: Research Published on:

  23. Bone morphogenetic protein 4 (BMP4) promotes the osteogenic differentiation and the bone regenerative potential of muscle-derived stem cells (MDSCs). BMP4 also promotes the self-renewal of both embryonic and s...

    Authors: Haizi Cheng, Xueqin Gao, Matthieu Huard, Aiping Lu, Joseph J. Ruzbarsky, Sara Amra, Bing Wang and Johnny Huard
    Citation: Stem Cell Research & Therapy 2022 13:385
    Content type: Research Published on:

  24. Hyaluronan (HA) has previously been identified as an integral component of the limbal stem cell niche in vivo. In this study, we investigated whether a similar HA matrix is also expressed in vitro providing a ...

    Authors: Sudan Puri, Isabel Y. Moreno, Mingxia Sun, Sudhir Verma, Xiao Lin, Tarsis F. Gesteira and Vivien J. Coulson-Thomas
    Citation: Stem Cell Research & Therapy 2022 13:384
    Content type: Research Published on:

  26. Tissue engineering focuses on reconstructing the damaged meniscus by mimicking the native meniscus. The application of mechanical loading on chondrocyte-laden decellularized whole meniscus is providing the nat...

    Authors: Mehri Shadi, Tahereh Talaei-Khozani, Mahsa Sani, Radmarz Hosseinie, Hossein Parsaei and Zahra Vojdani
    Citation: Stem Cell Research & Therapy 2022 13:382
    Content type: Research Published on:

  27. Authors: Feng Zhi, Yi Ding, Rong Wang, Yujiao Yang, Kaiming Luo and Fei Hua
    Citation: Stem Cell Research & Therapy 2022 13:381
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2021 12:157

  28. Tendon healing is clinically challenging largely due to its inferior regenerative capacity. We have previously prepared a soluble, DNA-free, urea-extracted bovine tendon-derived extracellular matrix (tECM) tha...

    Authors: Ying Rao, Chenxian Zhu, Hoi Ching Suen, Shuting Huang, Jinyue Liao, Dai Fei Elmer Ker, Rocky S. Tuan and Dan Wang
    Citation: Stem Cell Research & Therapy 2022 13:380
    Content type: Research Published on:

  29. Acute kidney injury (AKI) is a complex disease and can be generally divided into prerenal, intrarenal, and postrenal AKI (PR-AKI). Previous studies have shown that mesenchymal stem cells (MSCs)-derived extrace...

    Authors: Weihui Li, Wei Wang, Xin He, Zheng Liao, Aili Aierken, Jinlian Hua, Yan Wang, Dezhang Lu and Shiqiang Zhang
    Citation: Stem Cell Research & Therapy 2022 13:379
    Content type: Research Published on:

  30. Stroke is the leading cause of disability worldwide, resulting in severe damage to the central nervous system and disrupting neurological functions. There is no effective therapy for promoting neurological rec...

    Authors: Yi-Chao Ye, Zhe-Han Chang, Peng Wang, You-Wei Wang, Jun Liang, Chong Chen, Jing-Jing Wang, Hong-Tao Sun, Yi Wang and Xiao-Hong Li
    Citation: Stem Cell Research & Therapy 2022 13:378
    Content type: Research Published on:

  31. Breast cancer is the most common malignancy in women worldwide, and its treatment largely depends on mastectomy. Patients after mastectomy suffer from crippled body image, self-esteem, and quality of life. Pos...

    Authors: Xueqin Dai, Xinye Wang, Chuanyu Yang, Maobo Huang, Zhongmei Zhou, Ying Qu, Xiaojiang Cui, Rong Liu and Ceshi Chen
    Citation: Stem Cell Research & Therapy 2022 13:377
    Content type: Research Published on:

  32. All-trans retinoic acid (ATRA) plays an essential role during human eye development, being temporally and spatially adjusted to create gradient concentrations that guide embryonic anterior and posterior axis f...

    Authors: Helena Isla-Magrané, Maddalen Zufiaurre-Seijo, José García-Arumí and Anna Duarri
    Citation: Stem Cell Research & Therapy 2022 13:376
    Content type: Short report Published on:

  34. Inflammatory microenvironment promotes odontoblastic differentiation in human dental pulp stem cells (hDPSCs), but the regulatory mechanisms remain unclear. In this study, we aimed to explore the role of TAS2R...

    Authors: Wen Kang, Yiwen Wang, Jiaying Li, Weige Xie, Dan Zhao, Li Wu, Hongwei Wang and Sijing Xie
    Citation: Stem Cell Research & Therapy 2022 13:374
    Content type: Research Published on:

  35. Renal tubular epithelial–myofibroblast transdifferentiation (EMT) plays a key role in the regulation of renal fibrosis. Exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs) play a crucia...

    Authors: Zhenhua Qiu, Zhihui Zhong, Yuehan Zhang, Haoling Tan, Bo Deng and Guohuang Meng
    Citation: Stem Cell Research & Therapy 2022 13:373
    Content type: Research Published on:

  36. Hair follicle mesenchymal stem cells (HF-MSCs) have great potential for cell therapy. Traditional method to isolate whisker HF-MSC is time-consuming and few in cell numbers. How to quickly and conveniently obt...

    Authors: Yuyang Gan, Hailin Wang, Lijuan Du, Zhexiang Fan, Pingping Sun, Kaitao Li, Qian Qu, Jin Wang, Ruosi Chen, Zhiqi Hu and Yong Miao
    Citation: Stem Cell Research & Therapy 2022 13:372
    Content type: Research Published on:

  37. Parkinson's disease (PD) is the second most predominant neurodegenerative disease worldwide. It is recognized clinically by severe complications in motor function caused by progressive degeneration of dopamine...

    Authors: Reza Mosaddeghi Heris, Milad Shirvaliloo, Sanaz Abbaspour-Aghdam, Ali Hazrati, Ali Shariati, Hamed Rahmani Youshanlouei, Farhad Jadidi Niaragh, Hamed Valizadeh and Majid Ahmadi
    Citation: Stem Cell Research & Therapy 2022 13:371
    Content type: Review Published on:

  38. Islet transplantation is an excellent method for the treatment of type I diabetes mellitus. However, due to the limited number of donors, cumbersome isolation and purification procedures, and immune rejection,...

    Authors: Pengxiu Dai, Guixiang Qi, Haojie Xu, Mingde Zhu, Jiakai Li, Yijing Chen, Luwen Zhang, Xinke Zhang and Yihua Zhang
    Citation: Stem Cell Research & Therapy 2022 13:370
    Content type: Research Published on:

  39. RUNX1T1 (Runt-related transcription factor 1, translocated to 1), a myeloid translocation gene (MTG) family member, is usually investigated as part of the fusion protein RUNX1-RUNX1T1 for its role in acute mye...

    Authors: Nan Hu, Linqing Zou, Cheng Wang and Guoqi Song
    Citation: Stem Cell Research & Therapy 2022 13:369
    Content type: Review Published on:

  40. Salivary glands produce saliva that play essential roles in digestion and oral health. Derivation of salivary gland organoids from pluripotent stem cells (PSCs) provides a powerful platform to model the organo...

    Authors: Siqi Zhang, Yi Sui, Shuang Yan, Yifei Zhang, Chong Ding, Xiaodong Su, Jingwei Xiong and Shicheng Wei
    Citation: Stem Cell Research & Therapy 2022 13:368
    Content type: Research Published on:

  41. Ischemia–reperfusion injury (IRI)-induced acute kidney injury (AKI) can repair itself completely. However, most moderate and severe patients undergoing IRI-AKI progress to chronic kidney disease due to incompl...

    Authors: Xiangcheng Xie, Xiu Yang, Junxia Wu, Shengjie Tang, LiLi Yang, Xiao Fei and Ming Wang
    Citation: Stem Cell Research & Therapy 2022 13:367
    Content type: Research Published on:

  42. The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide consideration because of their immense potential for immunomodulation and their therapeutic function in tissue regeneration. MS...

    Authors: Ria Margiana, Alexander Markov, Angelina O. Zekiy, Mohammed Ubaid Hamza, Khalid A. Al-Dabbagh, Sura Hasan Al-Zubaidi, Noora M. Hameed, Irshad Ahmad, R. Sivaraman, Hamzah H. Kzar, Moaed E. Al-Gazally, Yasser Fakri Mustafa and Homayoon Siahmansouri
    Citation: Stem Cell Research & Therapy 2022 13:366
    Content type: Review Published on:

  43. High morbidity and mortality rates of the COVID-19 pandemic have made it a global health priority. Acute respiratory distress syndrome (ARDS) is one of the most important causes of death in COVID-19 patients. ...

    Authors: Hamid Reza Aghayan, Fatemeh Salimian, Atefeh Abedini, Samrand Fattah Ghazi, Masud Yunesian, Sepideh Alavi-Moghadam, Jalil Makarem, Keivan Majidzadeh-A, Ali Hatamkhani, Maryam Moghri, Abbas Danesh, Mohammad Reza Haddad-Marandi, Hassan Sanati, Fereshteh Abbasvandi, Babak Arjmand, Pourya Azimi…
    Citation: Stem Cell Research & Therapy 2022 13:365
    Content type: Research Published on:

  47. Authors: Bo-Feng Yin, Zhi-Ling Li, Zi-Qiao Yan, Zheng Guo, Jia-Wu Liang, Qian Wang, Zhi-Dong Zhao, Pei-Lin Li, Rui-Cong Hao, Meng-Yue Han, Xiao-Tong Li, Ning Mao, Li Ding, Da-Fu Chen, Yue Gao and Heng Zhu
    Citation: Stem Cell Research & Therapy 2022 13:361
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2022 13:241

  49. Impairment in neurogenesis correlates with memory and  cognitive dysfunction in AD patients. In the recent decade, therapies with stem cell bases are growing and proved to be efficient. This study is a prelimi...

    Authors: Gozal Bahlakeh, Reza Rahbarghazi, Ali Abedelahi, Saeed Sadigh-Eteghad and Mohammad Karimipour
    Citation: Stem Cell Research & Therapy 2022 13:343
    Content type: Research Published on:

  50. Authors: Charlotte Sarre, Rafael Contreras-Lopez, Nitirut Nernpermpisooth, Christian Barrere, Sarah Bahraoui, Claudia Terraza, Gautier Tejedor, Anne Vincent, Patricia Luz-Crawford, Kantapich Kongpol, Sarawut Kumphune, Christophe Piot, Joel Nargeot, Christian Jorgensen, Farida Djouad and Stéphanie Barrere-Lemaire
    Citation: Stem Cell Research & Therapy 2022 13:338
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2022 13:167

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