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  1. Mesenchymal stem cells (MSCs) were considered a regenerative therapeutic approach in both acute and chronic diseases. However, whether MSCs regulate the antioxidant metabolism of CD4+ T cells and weaken immunosen...

    Authors: Yanlian Xiong, Yueming Wang, Jiashen Zhang, Nannan Zhao, Hengchao Zhang, Aiping Zhang, Dongmei Zhao, Zhenhai Yu, Yancun Yin, Lele Song, Yanlei Xiong and Xiying Luan
    Citation: Stem Cell Research & Therapy 2020 11:468
  2. Although mitochondrial functions are essential for cell survival, their critical roles in stem cell fate, including proliferation, differentiation, and senescence, remain elusive. Ginsenoside Rg3 exhibits vari...

    Authors: Taeui Hong, Moon Young Kim, Dat Da Ly, Su Jung Park, Young Woo Eom, Kyu-Sang Park and Soon Koo Baik
    Citation: Stem Cell Research & Therapy 2020 11:467
  3. Premature ovarian insufficiency (POI) is an ovarian dysfunction that seriously affects a woman’s physiological health and reproduction. Mesenchymal stem cell (MSC) transplantation offers a promising treatment ...

    Authors: Yan Zhao, Jiao Ma, Peiye Yi, Jun Wu, Feiyan Zhao, Wan Tu, Wenjing Liu, Tianda Li, Yan Deng, Jie Hao, Hongmei Wang and Long Yan
    Citation: Stem Cell Research & Therapy 2020 11:466
  4. Inflammatory smooth muscle cells (iSMCs) generated from adventitial stem/progenitor cells (AdSPCs) have been recognised as a new player in cardiovascular disease, and microRNA-214-3p (miR-214-3p) has been impl...

    Authors: Shiping He, Feng Yang, Mei Yang, Weiwei An, Eithne Margaret Maguire, Qishan Chen, Rui Xiao, Wei Wu, Li Zhang, Wen Wang and Qingzhong Xiao
    Citation: Stem Cell Research & Therapy 2020 11:465
  5. The aim of this study was to determine whether the combination of MSC implantation with miRNA-126-3p overexpression would further improve the surgical results after vein grafting.

    Authors: Qingxi Qu, Limei Wang, Weidong Bing, Yanwen Bi, Chunmei Zhang, Xuanxuan Jing and Linghong Liu
    Citation: Stem Cell Research & Therapy 2020 11:464
  6. Congenital muscular dystrophies (CMD) are a clinically and genetically heterogeneous group of neuromuscular disorders characterized by muscle weakness. The two most prevalent forms of CMD, collagen VI-related ...

    Authors: Vitali Alexeev, Jacquelyn Olavarria, Paolo Bonaldo, Luciano Merlini and Olga Igoucheva
    Citation: Stem Cell Research & Therapy 2020 11:463
  7. Mesenchymal stem cells (MSCs) activate the endogenous immune regulatory system, inducing a therapeutic effect in recipients. MSCs have demonstrated the ability to modulate the differentiation of myeloid cells ...

    Authors: Maitane Ortiz-Virumbrales, Ramón Menta, Laura M. Pérez, Ornella Lucchesi, Pablo Mancheño-Corvo, Álvaro Avivar-Valderas, Itziar Palacios, Angel Herrero-Mendez, Wilfried Dalemans, Olga de la Rosa and Eleuterio Lombardo
    Citation: Stem Cell Research & Therapy 2020 11:462
  8. Osteogenesis is a complex biological process which requires the coordination of multiple molecular mechanisms. This research aimed to explore the biological role and underlying regulatory mechanism of circSIPA...

    Authors: Yuzhi Li, Minxia Bian, Zhou Zhou, Xiao Wu, Xingyun Ge, Tong Xiao and Jinhua Yu
    Citation: Stem Cell Research & Therapy 2020 11:461
  9. Adipose-derived stem cells (ADSCs) promote tissue regeneration and repair. Cryoprotective agents (CPAs) protect cells from cryodamage during cryopreservation. Safe and efficient cryopreservation of ADSCs is cr...

    Authors: Tian-Yu Zhang, Poh-Ching Tan, Yun Xie, Xiao-Jie Zhang, Pei-Qi Zhang, Yi-Ming Gao, Shuang-Bai Zhou and Qing-Feng Li
    Citation: Stem Cell Research & Therapy 2020 11:460
  10. Previous studies have demonstrated that no-option angiitis-induced critical limb ischemia (NO-AICLI) could be significantly improved by transplantation of peripheral blood-derived stem cells (PBDSCs). Addition...

    Authors: Gang Fang, Xiaolang Jiang, Yuan Fang, Tianyue Pan, Hao Liu, Bichen Ren, Zheng Wei, Shiyang Gu, Bin Chen, Junhao Jiang, Yun Shi, Daqiao Guo, Peng Liu, Weiguo Fu and Zhihui Dong
    Citation: Stem Cell Research & Therapy 2020 11:458
  11. Bladder cancer (BLCA) is the fifth most common type of cancer worldwide, with high recurrence and progression rates. Although considerable progress has been made in the treatment of BLCA through accurate typin...

    Authors: Chaozhi Tang, Jiakang Ma, Xiuli Liu and Zhengchun Liu
    Citation: Stem Cell Research & Therapy 2020 11:457
  12. Efficient osteogenic differentiation of mesenchymal stem cells (MSCs) is a critical step in the treatment of bone defects and skeletal disorders, which present challenges for cell-based therapy and regenerativ...

    Authors: Mahsa Ghorbaninejad, Maliheh Khademi-Shirvan, Samaneh Hosseini and Mohamadreza Baghaban Eslaminejad
    Citation: Stem Cell Research & Therapy 2020 11:456
  13. Cervical cancer is the most prevalent gynecological malignancies accompanied by high mortality, where finding a more effective therapeutic option for cervical cancer is necessary. The inhibitory role of microR...

    Authors: Feng Ding, Jinhua Liu and Xiaofei Zhang
    Citation: Stem Cell Research & Therapy 2020 11:455
  14. Human hair follicle mesenchymal stem cells (hHFMSCs) isolated from hair follicles possess multilineage differentiation potential. OCT4 is a gene critically associated with pluripotency properties. The cell mor...

    Authors: Xiaozhen Yu, Pengpeng Sun, Xingang Huang, Hua Chen, Weiqing Huang, Yingchun Ruan, Weina Jiang, Xiaohua Tan and Zhijing Liu
    Citation: Stem Cell Research & Therapy 2020 11:454

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:61

  15. Primary immunodeficiency diseases (PIDs) are rare diseases that are characterized by genetic mutations that damage immunological function, defense, or both. Some of these rare diseases are caused by aberration...

    Authors: C. Eguizabal, L. Herrera, M. Inglés-Ferrándiz and J. C. Izpisua Belmonte
    Citation: Stem Cell Research & Therapy 2020 11:453

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:250

  16. We have previously verified the beneficial effects of exosomes from endothelial progenitor cells (EPC-EXs) in ischemic stroke. However, the effects of EPC-EXs in hemorrhagic stroke have not been investigated. ...

    Authors: Yuchen Li, Jinju Wang, Shuzhen Chen, Pei Wu, Shancai Xu, Chunlei Wang, Huaizhang Shi and Ji Bihl
    Citation: Stem Cell Research & Therapy 2020 11:330
  17. Scar formation, which may be caused by myofibroblast aggregations, is the greatest challenge during skin wound healing in the clinical setting. Studies have indicated that epidermal stem cells (EPSC) improve w...

    Authors: Mengna Duan, Yan Zhang, Haiyang Zhang, Yupeng Meng, Ming Qian and Guokun Zhang
    Citation: Stem Cell Research & Therapy 2020 11:452
  18. Respiratory tract fistulas (or fistulae) are abnormal communications between the respiratory system and the digestive tract or the adjacent organs. The origin can be congenital or, more frequently, iatrogenic ...

    Authors: Angelo Trivisonno, Dania Nachira, Ivo Boškoski, Venanzio Porziella, Giuliana Di Rocco, Silvia Baldari and Gabriele Toietta
    Citation: Stem Cell Research & Therapy 2020 11:451
  19. Acute liver failure (ALF) is a complicated condition that is characterized by global hepatocyte death and often requires immediate liver transplantation. However, this therapy is limited by shortage of donor o...

    Authors: Defu Kong, Huiming Xu, Mo Chen, Yeping Yu, Yongbing Qian, Tian Qin, Ying Tong, Qiang Xia and Hualian Hang
    Citation: Stem Cell Research & Therapy 2020 11:449
  20. Gene therapy is being investigated for a range of serious lung diseases, such as cystic fibrosis and emphysema. Recombinant adeno-associated virus (rAAV) is a well-established, safe, viral vector for gene deli...

    Authors: Helena Meyer-Berg, Lucia Zhou Yang, María Pilar de Lucas, Alberto Zambrano, Stephen C. Hyde and Deborah R. Gill
    Citation: Stem Cell Research & Therapy 2020 11:448
  21. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Mengge Wang, Hongtao Wang, Yuqi Wen, Xiaoyuan Chen, Xin Liu, Jie Gao, Pei Su, Yuanfu Xu, Wen Zhou, Lihong Shi and Jiaxi Zhou
    Citation: Stem Cell Research & Therapy 2020 11:446

    The original article was published in Stem Cell Research & Therapy 2018 9:340

  22. Osteonecrosis of femoral head (ONFH) is a seriously degenerative disease with no effective therapies to slow its progression. Several studies have reported short-term efficacy of stem cells on early-stage ONFH...

    Authors: Lianghao Mao, Pan Jiang, Xuan Lei, Chenlie Ni, Yiming Zhang, Bing Zhang, Qiping Zheng and Dapeng Li
    Citation: Stem Cell Research & Therapy 2020 11:445
  23. Dysfunction of the DNA methylation was associated with stem cell reprogramming. Moreover, DNA methyltransferase 1 (DNMT1) deficiency was involved in the differentiation of hair follicle stem cell (HFSc), but t...

    Authors: Fangcao Jin, Min Li, Xuyang Li, Yunpeng Zheng, Kun Zhang, Xiaojun Liu, Bingjie Cai and Guangwen Yin
    Citation: Stem Cell Research & Therapy 2020 11:444
  24. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Daphne Hingert, Karin Ekström, Jonathan Aldridge, Rossella Crescitelli and Helena Brisby
    Citation: Stem Cell Research & Therapy 2020 11:443

    The original article was published in Stem Cell Research & Therapy 2020 11:323

  25. Bone marrow mesenchymal stem cells (BMSCs) have been used as important cell-based tools for clinical applications. Oxidative stress-induced apoptosis causes a low survival rate after transplantation, and the u...

    Authors: Chongxi Fan, Jianyu Feng, Chi Tang, Zhengbin Zhang, Yingtong Feng, Weixun Duan, Mingming Zhai, Zedong Yan, Liwen Zhu, Lele Feng, Hanzhao Zhu and Erping Luo
    Citation: Stem Cell Research & Therapy 2020 11:442
  26. Diabetes is associated with the dysfunction of endothelial progenitor cells (EPCs), characterized as impaired angiogenesis, a phenomenon thought to be involved in the development of diabetic foot. lncRNA plays...

    Authors: Yang Li, Kangkang Zhi, Shilong Han, Xue Li, Maoquan Li, Weishuai Lian, Haijun Zhang and Xiaoping Zhang
    Citation: Stem Cell Research & Therapy 2020 11:441
  27. Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) from the human umbilical cord have been studied extensively due to their immunomodulatory functions. Large-conductance Ca2+-activated K+ (BKCa channels) ch...

    Authors: Ahui Song, Jingjing Wang, Yan Tong, Junyan Fang, Yi Zhang, Huiping Zhang, Hongqiang Ruan, Kai Wang and Yingli Liu
    Citation: Stem Cell Research & Therapy 2020 11:440
  28. Lineage tracing is the most widely used technique to track the migration, proliferation, and differentiation of specific cells in vivo. The currently available gene-targeting technologies have been developing ...

    Authors: Yue Zhang, Fanhong Zeng, Xu Han, Jun Weng and Yi Gao
    Citation: Stem Cell Research & Therapy 2020 11:438
  29. The COVID-19 pandemic has negatively impacted the global public health and the international economy; therefore, there is an urgent need for an effective therapy to treat COVID-19 patients. Mesenchymal stem ce...

    Authors: Sara Al-Khawaga and Essam M. Abdelalim
    Citation: Stem Cell Research & Therapy 2020 11:437
  30. Mesenchymal stem cells are a promising cell source for chondrogenic differentiation and have been widely used in several preclinical and clinical studies. However, they are prone to an unwanted differentiation...

    Authors: Shahrbanoo Jahangir, David Eglin, Naomi Pötter, Mojtaba Khozaei Ravari, Martin J. Stoddart, Ali Samadikuchaksaraei, Mauro Alini, Mohammadreza Baghaban Eslaminejad and Majid Safa
    Citation: Stem Cell Research & Therapy 2020 11:436
  31. The transplantation of bone marrow mesenchymal stem cells (BMSCs) is a promising therapeutic strategy for wound healing. However, the poor migration capacity and low survival rate of transplanted BMSCs in woun...

    Authors: Ling Guo, Juan Du, Dan-feng Yuan, Ya Zhang, Shu Zhang, Hua-cai Zhang, Jun-wei Mi, Ya-lei Ning, Min-jia Chen, Da-lin Wen, Jian-hui Sun, Di Liu, Ling Zeng, Anqiang Zhang, Jianxin Jiang and Hong Huang
    Citation: Stem Cell Research & Therapy 2020 11:434
  32. Current strategies for craniofacial defect are faced with unmet outcome. Combining 3D-printing with safe, noninvasive magnetic therapy could be a promising breakthrough.

    Authors: Chang Tu, Jingyuan Chen, Chunwei Huang, Yifan Xiao, Xiangyu Tang, Hao Li, Yongzhuang Ma, Jiyuan Yan, Weigang Li, Hua Wu and Chaoxu Liu
    Citation: Stem Cell Research & Therapy 2020 11:433
  33. The autologous nerve graft, despite its donor site morbidity and unpredictable functional recovery, continues to be the gold standard in peripheral nerve repair. Rodent research studies have shown promising re...

    Authors: Silvia Palombella, Martino Guiotto, Gillian C. Higgins, Laurent L. Applegate, Wassim Raffoul, Mario Cherubino, Andrew Hart, Mathis O. Riehle and Pietro G. di Summa
    Citation: Stem Cell Research & Therapy 2020 11:432
  34. Considerable progress has been made in converting human pluripotent stem cells (hPSCs) into cortical neurons for disease modeling and regenerative medicine. However, these procedures are hard to provide suffic...

    Authors: Shumei Zhao, Kui Duan, Zongyong Ai, Baohua Niu, Yanying Chen, Ruize Kong and Tianqing Li
    Citation: Stem Cell Research & Therapy 2020 11:431
  35. Bronchioalveolar stem cells (BASCs) located at the bronchioalveolar-duct junction (BADJ) are stem cells residing in alveoli and terminal bronchioles that can self-renew and differentiate into alveolar type (AT...

    Authors: Naoya Kawakita, Hiroaki Toba, Keiko Miyoshi, Shinichi Sakamoto, Daisuke Matsumoto, Mika Takashima, Mariko Aoyama, Seiya Inoue, Masami Morimoto, Takeshi Nishino, Hiromitsu Takizawa and Akira Tangoku
    Citation: Stem Cell Research & Therapy 2020 11:430
  36. Cancer stem cells (CSCs) are considered to be responsible for tumor initiation, formation, and poor prognosis of cancer patients. However, the rarity of CSCs in clinical samples makes it difficult to elucidate...

    Authors: Shuichi Fujiwara, Teruya Kawamoto, Yohei Kawakami, Yasufumi Koterazawa, Hitomi Hara, Toshiyuki Takemori, Kazumichi Kitayama, Shunsuke Yahiro, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Michiyo Koyanagi-Aoi, Takashi Aoi, Ryosuke Kuroda and Toshihiro Akisue
    Citation: Stem Cell Research & Therapy 2020 11:429
  37. Stem cell transplantation has been proposed as an alternative treatment for intractable optic nerve disorders characterized by irrecoverable loss of cells. Mesenchymal stem cells, with varying tissue regenerat...

    Authors: Kyungmin Koh, Mira Park, Eun Soo Bae, Van-An Duong, Jong-Moon Park, Hookeun Lee and Helen Lew
    Citation: Stem Cell Research & Therapy 2020 11:428
  38. Periodontal tissue regeneration (PTR) is the ultimate goal of periodontal therapy. Currently, stem cell therapy is considered a promising strategy for achieving PTR. However, there is still no conclusive compa...

    Authors: Qiang Li, Guangwen Yang, Jialing Li, Meng Ding, Na Zhou, Heng Dong and Yongbin Mou
    Citation: Stem Cell Research & Therapy 2020 11:427
  39. Mesenchymal stem/stromal cells (MSC) have immunomodulatory properties, studied in a wide range of diseases. Validated quality controls must confirm this activity in the context of clinical trials. This study p...

    Authors: Tess Nicotra, Aurélie Desnos, Justine Halimi, Hélène Antonot, Loïc Reppel, Thomas Belmas, Alice Freton, Floriane Stranieri, Miryam Mebarki, Jérôme Larghero, Audrey Cras and Lionel Faivre
    Citation: Stem Cell Research & Therapy 2020 11:426
  40. As a critical cellular component in the hepatic stem cell niche, hepatic stellate cells (HSCs) play critical roles in regulating the expansion of hepatic stem cells, liver regeneration, and fibrogenesis. Howev...

    Authors: Jian-Yun Ge, Yun-Wen Zheng, Tomonori Tsuchida, Kinji Furuya, Hiroko Isoda, Hideki Taniguchi, Nobuhiro Ohkohchi and Tatsuya Oda
    Citation: Stem Cell Research & Therapy 2020 11:425
  41. Mesenchymal stem cells (MSCs) are adult stromal cells that reside in virtually all postnatal tissues. Due to their regenerative and immunomodulatory capacities, MSCs have attracted growing attention during the...

    Authors: Jiangmei Wang, Jie Xia, Ruoqiong Huang, Yaoqin Hu, Jiajie Fan, Qiang Shu and Jianguo Xu
    Citation: Stem Cell Research & Therapy 2020 11:424
  42. Currently, numerous animal studies have shown that exposure to commonly used general anesthetics during pregnancy may cause neurocognitive impairment in the offspring. Reportedly, exposure to sevoflurane durin...

    Authors: Yi Zhang, Ziyi Wu, Xingyue Li, Yuxiao Wan, Yinong Zhang and Ping Zhao
    Citation: Stem Cell Research & Therapy 2020 11:423
  43. Renal tubulointerstitial fibrosis (TIF) plays an important role in the progression of chronic kidney disease (CKD) and its pathogenesis involves epithelial-to-mesenchymal transition (EMT) upon renal injury. Re...

    Authors: Mirae Lee, Seok-hyung Kim, Jong Hyun Jhee, Tae Yeon Kim, Hoon Young Choi, Hyung Jong Kim and Hyeong Cheon Park
    Citation: Stem Cell Research & Therapy 2020 11:422
  44. Extracellular vesicles (EVs) are secretory lipid membranes with the ability to regulate cellular functions by exchanging biological components between different cells. Resident skin cells such as keratinocytes...

    Authors: Golara Nasiri, Negar Azarpira, Aliakbar Alizadeh, Sanaz Goshtasbi and Lobat Tayebi
    Citation: Stem Cell Research & Therapy 2020 11:421
  45. Patients with severe acute pancreatitis (SAP), which is characterized by high morbidity and mortality, account for an increasing medical burden worldwide. We previously found that mesenchymal stem cells (MSCs)...

    Authors: Guodong Song, Jia Zhou, Ruimei Song, Dalu Liu, Weidi Yu, Wangcheng Xie, Zhilong Ma, Jian Gong, Hongbo Meng, Tingsong Yang and Zhenshun Song
    Citation: Stem Cell Research & Therapy 2020 11:420

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