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  1. An increasing number of private clinics in Australia are marketing and providing autologous stem cell therapies to patients. Although advocates point to the importance of medical innovation and the primacy of ...

    Authors: Alison K McLean, Cameron Stewart and Ian Kerridge
    Citation: Stem Cell Research & Therapy 2015 6:12
    Content type: Review Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:69

  2. The immunomodulatory properties of human amnion epithelial cells (hAECs) have been previously described in several disease models. We previously reported on the ability of hAECs to influence macrophage phenoty...

    Authors: Jean L Tan, Siow T Chan, Camden Y Lo, James A Deane, Courtney A McDonald, Claude CA Bernard, Euan M Wallace and Rebecca Lim
    Citation: Stem Cell Research & Therapy 2015 6:8
    Content type: Research Published on:

  3. Intra-arterial cell infusion is an efficient delivery route with which to target organs such as the ischemic brain. However, adverse events including microembolisms and decreased cerebral blood flow were recen...

    Authors: Li-li Cui, Erja Kerkelä, Abdulhameed Bakreen, Franziska Nitzsche, Anna Andrzejewska, Adam Nowakowski, Miroslaw Janowski, Piotr Walczak, Johannes Boltze, Barbara Lukomska and Jukka Jolkkonen
    Citation: Stem Cell Research & Therapy 2015 6:11
    Content type: Research Published on:

  4. Percutaneous transluminal renal angioplasty (PTRA) fails to fully improve cardiac injury and dysfunction in patients with renovascular hypertension (RVH). Mesenchymal stem cells (MSCs) restore renal function, ...

    Authors: Alfonso Eirin, Xiang-Yang Zhu, Christopher M Ferguson, Scott M Riester, Andre J van Wijnen, Amir Lerman and Lilach O Lerman
    Citation: Stem Cell Research & Therapy 2015 6:7
    Content type: Research Published on:

  5. Mesenchymal stem cells (MSCs) are a promising source of cells for regenerative therapies. Although they can be isolated easily from several tissues, cell expansion is limited since their properties are lost wi...

    Authors: Carlos Luzzani, Gabriel Neiman, Ximena Garate, María Questa, Claudia Solari, Darío Fernandez Espinosa, Marcela García, Ana Lía Errecalde, Alejandra Guberman, María Elida Scassa, Gustavo Emilio Sevlever, Leonardo Romorini and Santiago Gabriel Miriuka
    Citation: Stem Cell Research & Therapy 2015 6:6
    Content type: Research Published on:

  6. Urine-derived stem cells (USCs) have the ability to differentiate into osteogenic lineage. Previous studies have raised the possibility that USCs could be used for bone repair. To harness the power of USCs in ...

    Authors: Junjie Guan, Jieyuan Zhang, Zhenzhong Zhu, Xin Niu, Shangchun Guo, Yang Wang and Changqing Zhang
    Citation: Stem Cell Research & Therapy 2015 6:5
    Content type: Research Published on:

  7. Increased levels of angiotensin II (Ang II) and activity of Ang II receptor type 1 (AT1R) elicit detrimental effects in cardiovascular disease. However, the role of Ang II receptor type 2 (AT2R) remains poorly...

    Authors: Izuagie Attairu Ikhapoh, Christopher J Pelham and Devendra K Agrawal
    Citation: Stem Cell Research & Therapy 2015 6:4
    Content type: Research Published on:

  8. The different distribution of T cells among activation/differentiation stages in immune disorders may condition the outcome of mesenchymal stromal cell (MSC)-based therapies. Indeed, the effect of MSCs in the ...

    Authors: Paula Laranjeira, Monia Pedrosa, Susana Pedreiro, Joana Gomes, Antonio Martinho, Brigida Antunes, Tania Ribeiro, Francisco Santos, Helder Trindade and Artur Paiva
    Citation: Stem Cell Research & Therapy 2015 6:3
    Content type: Research Published on:

  9. Autologous fat grafting is commonly used to correct soft-tissue contour deformities. However, results are impaired by a variable and unpredictable resorption rate. Autologous adipose-derived stromal cells in c...

    Authors: Rossana Domenis, Lara Lazzaro, Sarah Calabrese, Damiano Mangoni, Annarita Gallelli, Evgenia Bourkoula, Ivana Manini, Natascha Bergamin, Barbara Toffoletto, Carlo A Beltrami, Antonio P Beltrami, Daniela Cesselli and Pier Camillo Parodi
    Citation: Stem Cell Research & Therapy 2015 6:2
    Content type: Research Published on:

  10. Pluripotent stem cells are increasingly used to build therapeutic models, including the transplantation of neural progenitors derived from human embryonic stem cells (hESCs). Recently, long non-coding RNAs (ln...

    Authors: Chu-Fan Mo, Fang-Chun Wu, Kang-Yu Tai, Wei-Chun Chang, Kai-Wei Chang, Hung-Chih Kuo, Hong-Nerng Ho, Hsin-Fu Chen and Shau-Ping Lin
    Citation: Stem Cell Research & Therapy 2015 6:1
    Content type: Research Published on:

  11. Microcomputed tomography (microCT) has become a standard and essential tool for quantifying structure-function relationships, disease progression, and regeneration in preclinical models and has facilitated num...

    Authors: Joel D Boerckel, Devon E Mason, Anna M McDermott and Eben Alsberg
    Citation: Stem Cell Research & Therapy 2014 5:144
    Content type: Review Published on:

  12. Inflammation plays a crucial role in tissue regeneration, wound healing, and the success of tissue-engineered constructs. The aim of this study was to investigate the influence of human umbilical vein endothel...

    Authors: Sushma Bartaula-Brevik, Torbjorn O Pedersen, Anna L Blois, Panagiota Papadakou, Anna Finne-Wistrand, Ying Xue, Anne Isine Bolstad and Kamal Mustafa
    Citation: Stem Cell Research & Therapy 2014 5:143
    Content type: Research Published on:

  13. Mesenchymal cells are emerging as a promising cell platform for regenerative therapies. However, the fate of cells after transplantation in many different disease settings and tissue beds remains unclear.

    Authors: Hitesh Agrawal, Hulan Shang, Anna Parker Sattah, Ning Yang, Shayn M Peirce and Adam J Katz
    Citation: Stem Cell Research & Therapy 2014 5:142
    Content type: Research Published on:

  14. Heart disease remains the number one cause of death in developed countries. Loss of cardiomyocytes (CMs) due to aging or pathophysiological conditions (for example, myocardial infarction) is generally consider...

    Authors: Ronald A Li
    Citation: Stem Cell Research & Therapy 2014 5:141
    Content type: Editorial Published on:

  15. Bone marrow mesenchymal stem cells/multipotent stromal cells (MSCs) are recruited to sites of injury and subsequently support regeneration through differentiation or paracrine activity. During periods of stres...

    Authors: Austin Nuschke, Melanie Rodrigues, Donna B Stolz, Charleen T Chu, Linda Griffith and Alan Wells
    Citation: Stem Cell Research & Therapy 2014 5:140
    Content type: Research Published on:

  16. Mesenchymal stem cells (MSCs) are multipotent and have been derived from various tissues. Although MSCs share many basic features, they often display subtle tissue specific differences. We previously demonstra...

    Authors: Orly Ravid, Ofer Shoshani, Meirav Sela, Ada Weinstock, Tommy Weiss Sadan, Eyal Gur, Dov Zipori and Nir Shani
    Citation: Stem Cell Research & Therapy 2014 5:139
    Content type: Research Published on:

  17. Scleroderma is characterized by cutaneous manifestations that mainly affect the hands, arms and face. As of today, there is no treatment for fibrotic skin lesions of scleroderma. Previously we generated and va...

    Authors: Nicolas Serratrice, Laurie Bruzzese, Jérémy Magalon, Julie Véran, Laurent Giraudo, Houssein Aboudou, Djaffar Ould-Ali, Pierre Sébastien Nguyen, Olivier Bausset, Aurélie Daumas, Dominique Casanova, Brigitte Granel, Lucile Andrac-Meyer, Florence Sabatier and Guy Magalon
    Citation: Stem Cell Research & Therapy 2014 5:138
    Content type: Research Published on:

  19. Mesenchymal stem cells (MSCs) are considered to play important roles in wound repair and tissue remodeling. Hypertrophic scar (HTS) is a cutaneous condition characterized by deposits of excessive amount of col...

    Authors: Yi-Lun Liu, Wei-Hua Liu, Jin Sun, Tuan-Jie Hou, Yue-Ming Liu, Hai-Rong Liu, Yong-Hui Luo, Ning-Ning Zhao, Ying Tang and Feng-Mei Deng
    Citation: Stem Cell Research & Therapy 2014 5:136
    Content type: Research Published on:

  20. Dental follicle gives rise to one or several tissues of the periodontium including the periodontal ligament, cementum and/or alveolar bone. Whether Wnt5a is expressed in the postnatal periodontium or regulates...

    Authors: Lusai Xiang, Mo Chen, Ling He, Bin Cai, Yu Du, Xinchun Zhang, Chen Zhou, Chenglin Wang, Jeremy J Mao and Junqi Ling
    Citation: Stem Cell Research & Therapy 2014 5:135
    Content type: Research Published on:

  21. Mesenchymal stem cells (MSCs) are a multipotent population of adult stem cells, which may represent a promising therapeutic approach for neurological autoimmune diseases such as multiple sclerosis. The mouse i...

    Authors: Carmen Marin-Bañasco, Margarita Suardíaz García, Issac Hurtado Guerrero, Rafael Maldonado Sánchez, Guillermo Estivill-Torrús, Laura Leyva Fernández and Oscar Fernández Fernández
    Citation: Stem Cell Research & Therapy 2014 5:134
    Content type: Research Published on:

  22. Rhinosinusitis is characterized by inflammation extending from the mucosa of the nasal cavity into the paranasal sinuses. There are some aggravating features, such as immunosuppression, that can cause the nasa...

    Authors: Erica Ortiz, Albina Altemani, Afonso Celso Vigorito, Eulalia Sakano and Ester Maria Danielli Nicola
    Citation: Stem Cell Research & Therapy 2014 5:133
    Content type: Research Published on:

  23. Mesenchymal stem cells (MSCs) are widely investigated in clinical researches to treat various diseases. Classic culture medium for MSCs, even for clinical use, contains fetal bovine serum. The serum-containing...

    Authors: Youwei Wang, Hehe Wu, Zhouxin Yang, Ying Chi, Lei Meng, Aibin Mao, Shulin Yan, Shanshan Hu, Jianzhong Zhang, Yun Zhang, Wenbo Yu, Yue Ma, Tao Li, Yan Cheng, Yongjuan Wang, Shanshan Wang…
    Citation: Stem Cell Research & Therapy 2014 5:132
    Content type: Research Published on:

  24. The present study aimed to elucidate the therapeutic effects of mesenchymal stem cells (MSCs) derived from the bone marrow of rats (BM) against toxic effects of lead (Pb) on the male gonads of experimental rats.

    Authors: Amal I Hassan and Sally S Alam
    Citation: Stem Cell Research & Therapy 2014 5:131
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2017 8:32

  25. Mesenchymal stem cells (MSCs) transplantation has been demonstrated to be an effective strategy for the treatment of cardiovascular disease. However, the low survival rate of MSCs at local diseased tissue redu...

    Authors: Yue Xing, Jingying Hou, Tianzhu Guo, Shaoxin Zheng, Changqing Zhou, Hui Huang, Yuyang Chen, Kan Sun, Tingting Zhong, Jingfeng Wang, Honghao Li and Tong Wang
    Citation: Stem Cell Research & Therapy 2014 5:130
    Content type: Research Published on:

  26. Clinically, a good deal of injury from stroke results from ischemic-reperfusion. There is a loss of cerebral parenchyma and its associated cells, disruption of neuronal connections, compromise of the blood-bra...

    Authors: Lei Huang, Sunnie Wong, Evan Y Snyder, Milton H Hamblin and Jean-Pyo Lee
    Citation: Stem Cell Research & Therapy 2014 5:129
    Content type: Research Published on:

  28. There is a growing interest in the therapeutic utility of compounds derived from Curcuma longa, an herb of the Zingiberaceae family that has been part of traditional medicine for centuries. Recent reports suggest...

    Authors: Steven W Poser and Andreas Androutsellis-Theotokis
    Citation: Stem Cell Research & Therapy 2014 5:127
    Content type: Commentary Published on:

  29. The administration of stem cells holds promise as a potential therapy for spinal cord injury (SCI). Mesenchymal stem cells have advantages for clinical applications, since they can be easily obtained, are suit...

    Authors: Marcus Vinícius Pinheiro Mendonça, Ticiana Ferreira Larocca, Bruno Solano de Freitas Souza, Cristiane Flora Villarreal, Luiz Flávio Maia Silva, André Costa Matos, Marco Antonio Novaes, Cláudia Maria Pinheiro Bahia, Ana Carine de Oliveira Melo Martinez, Carla Martins Kaneto, Sissi Brandão Carneiro Furtado, Geraldo Pedral Sampaio, Milena Botelho Pereira Soares and Ricardo Ribeiro dos Santos
    Citation: Stem Cell Research & Therapy 2014 5:126
    Content type: Research Published on:

  30. Estrogen plays an important role in the osteogenic differentiation of mesenchymal stem cells, while stem cells from apical papilla (SCAP) can contribute to the formation of dentin/bone-like tissues. To date, t...

    Authors: Yao Li, Ming Yan, Zilu Wang, Yangyu Zheng, Junjun Li, Shu Ma, Genxia Liu and Jinhua Yu
    Citation: Stem Cell Research & Therapy 2014 5:125
    Content type: Research Published on:

  31. Several cellular sources of stem cells have been tested in the attempt to yield innovative interventions in acute kidney injury (AKI). Human liver stem cells (HLSCs) are cells isolated from the normal adult hu...

    Authors: Maria Beatriz Herrera Sanchez, Stefania Bruno, Cristina Grange, Marta Tapparo, Vincenzo Cantaluppi, Ciro Tetta and Giovanni Camussi
    Citation: Stem Cell Research & Therapy 2014 5:124
    Content type: Research Published on:

  32. Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible fibrotic lung disease, resulting in respiratory insufficiency and reduced survival. Pulmonary fibrosis is a result of repeated alveolar epi...

    Authors: Amiq Gazdhar, Iwona Grad, Luca Tamò, Mathias Gugger, Anis Feki and Thomas Geiser
    Citation: Stem Cell Research & Therapy 2014 5:123
    Content type: Research Published on:

  33. Fibrosis, or scar formation, is a pathological condition characterized by excessive production and accumulation of collagen, loss of tissue architecture, and organ failure in response to uncontrolled wound hea...

    Authors: Alexander Birbrair, Tan Zhang, Daniel Clark Files, Sandeep Mannava, Thomas Smith, Zhong-Min Wang, Maria Laura Messi, Akiva Mintz and Osvaldo Delbono
    Citation: Stem Cell Research & Therapy 2014 5:122
    Content type: Research Published on:

  34. The use of hematopoietic cell transplantation (HCT) has previously been shown to ameliorate cutaneous blistering in pediatric patients with recessive dystrophic epidermolysis bullosa (RDEB), an inherited skin ...

    Authors: Christopher Perdoni, John A McGrath and Jakub Tolar
    Citation: Stem Cell Research & Therapy 2014 5:121
    Content type: Research Published on:

  36. Ocular trauma is defined as a trauma caused by blunt or penetrating mechanisms on the eyeball and its peripheral structures, causing damage with different degrees of affection with temporary or permanent visua...

    Authors: Gustavo Jesús Vázquez-Zapién, Marlon Rojas-López, Raúl Jacobo Delgado-Macuil, Luis Rubén Martínez-Nava, David Guillermo Pérez-Ishiwara and Mónica Maribel Mata-Miranda
    Citation: Stem Cell Research & Therapy 2014 5:119
    Content type: Research Published on:

  37. In the field of skin tissue engineering, gelatin-chondroitin-6-sulfate-hyaluronic acid (Gel-C6S-HA) stents are a suitable bio skin substitute. The purpose was to investigate the effect of genetically-modified ...

    Authors: Renfu Quan, Xuan Zheng, Shichao Xu, Liang Zhang and Disheng Yang
    Citation: Stem Cell Research & Therapy 2014 5:118
    Content type: Research Published on:

  38. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are the most promising source of cardiomyocytes (CMs) for experimental and clinical applications, but their use is largely limited by a structurall...

    Authors: Renjun Zhu, Adriana Blazeski, Ellen Poon, Kevin D Costa, Leslie Tung and Kenneth R Boheler
    Citation: Stem Cell Research & Therapy 2014 5:117
    Content type: Review Published on:

  39. The existence of cancer stem cells (CSCs) has been associated with tumor initiation, therapy resistance, tumor relapse, angiogenesis, and metastasis. Curcumin, a plant ployphenol, has several anti-tumor effect...

    Authors: Shravanti Mukherjee, Minakshi Mazumdar, Samik Chakraborty, Argha Manna, Shilpi Saha, Poulami Khan, Pushpak Bhattacharjee, Deblina Guha, Arghya Adhikary, Sanhita Mukhjerjee and Tanya Das
    Citation: Stem Cell Research & Therapy 2014 5:116
    Content type: Research Published on:

  40. Avascular necrosis of femoral head (ANFH) is a progressive disease that often leads to hip joint dysfunction and even disability in young patients. Although the standard treatment, which is core decompression,...

    Authors: Yuanchen Ma, Tao Wang, Junxing Liao, Honglin Gu, Xinpeng Lin, Qing Jiang, Max K Bulsara, Minghao Zheng and Qiujian Zheng
    Citation: Stem Cell Research & Therapy 2014 5:115
    Content type: Research Published on:

  41. Repair of large bone defects remains a significant clinical challenge. Bone marrow stromal cells (BMSCs), a subset of which is known as bone marrow-derived mesenchymal stem cells, show therapeutic potential fo...

    Authors: Meadhbh Á Brennan, Audrey Renaud, Jérôme Amiaud, Markus T Rojewski, Hubert Schrezenmeier, Dominique Heymann, Valerie Trichet and Pierre Layrolle
    Citation: Stem Cell Research & Therapy 2014 5:114
    Content type: Research Published on:

  42. Adipose-derived stroma cells (ASCs) are attractive cells for cell-based gene therapy but are generally difficult to transfect. Nucleofection has proven to be an efficient method for transfection of primary cel...

    Authors: Angela Fülbier, Reinhild Schnabel, Stefanie Michael, Peter M Vogt, Sarah Strauß, Kerstin Reimers and Christine Radtke
    Citation: Stem Cell Research & Therapy 2014 5:113
    Content type: Research Published on:

  43. Mesenchymal stem cells have been increasingly used for cell-based therapies. Adipose-derived stem/stromal cells (ASCs) from the stromal vascular fraction (SVF) of fat tissue are a particularly attractive optio...

    Authors: Hetal D Marble, Bryan A Sutermaster, Manisha Kanthilal, Vera C Fonseca and Eric M Darling
    Citation: Stem Cell Research & Therapy 2014 5:145
    Content type: Research Published on:

  44. Mesenchymal stem cells (MSCs) have the ability to differentiate into osteoblasts, chondroblasts, adipocytes, and even myoblasts. Most studies have focused on finding MSCs in different parts of the body for med...

    Authors: Eduardo Branco de Sousa, Priscila Ladeira Casado, Vivaldo Moura Neto, Maria Eugenia Leite Duarte and Diego Pinheiro Aguiar
    Citation: Stem Cell Research & Therapy 2014 5:112
    Content type: Review Published on:

  45. Aromatic (ar-) turmerone is a major bioactive compound of the herb Curcuma longa. It has been suggested that ar-turmerone inhibits microglia activation, a property that may be useful in treating neurodegenerative...

    Authors: Joerg Hucklenbroich, Rebecca Klein, Bernd Neumaier, Rudolf Graf, Gereon Rudolf Fink, Michael Schroeter and Maria Adele Rueger
    Citation: Stem Cell Research & Therapy 2014 5:100
    Content type: Research Published on:

  46. Poor cell survival and limited functional benefits have restricted the efficacy of bone marrow mesenchymal stem cells (BMSCs) in the treatment of myocardial infarction. We showed recently that hypoxia precondi...

    Authors: Xian-Bao Liu, Jian-An Wang, Xiao-Ya Ji, Shan Ping Yu and Ling Wei
    Citation: Stem Cell Research & Therapy 2014 5:111
    Content type: Research Published on:

  47. Myocardial infarction is accompanied by a significant loss of cardiomyocytes (CMs). Functional CMs, differentiated from human embryonic stem cells (hESCs), offer a potentially unlimited cell source for cardiac...

    Authors: Alan Tin-Lun Lam, Allen Kuan-Liang Chen, Jian Li, William R Birch, Shaul Reuveny and Steve Kah-Weng Oh
    Citation: Stem Cell Research & Therapy 2014 5:110
    Content type: Research Published on:

  48. Systemic administration of mesenchymal stem (stromal) cells (MSCs) has shown benefit in a range of experimental models of acute kidney injury, although the reported mechanisms of action and requirement for MSC...

    Authors: Michelle M Duffy and Matthew D Griffin
    Citation: Stem Cell Research & Therapy 2014 5:109
    Content type: Commentary Published on:

  49. Asthma is characterized by a chronic inflammatory process which may lead to several changes in bone marrow cell composition. We hypothesized that bone marrow mononuclear cells (BMMCs) obtained from ovalbumin (...

    Authors: Soraia C Abreu, Mariana A Antunes, Lucas Mendonça, Vivian C Branco, Elga Bandeira de Melo, Priscilla C Olsen, Bruno L Diaz, Daniel J Weiss, Bruno D Paredes, Debora G Xisto, Marcelo M Morales and Patricia RM Rocco
    Citation: Stem Cell Research & Therapy 2014 5:108
    Content type: Research Published on:

  50. Preterm newborns often require mechanical respiratory support that can result in ventilation-induced lung injury (VILI), despite exogenous surfactant treatment. Human amnion epithelial cells (hAECs) reduce lun...

    Authors: Courtney A McDonald, Jacqueline M Melville, Graeme R Polglase, Graham Jenkin and Timothy JM Moss
    Citation: Stem Cell Research & Therapy 2014 5:107
    Content type: Research Published on:
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