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  1. Mesenchymal stem cell (MSC) therapy shows great promise for diabetic kidney disease (DKD) patients. Research has been carried out on this topic in recent years. The main goals of this paper are to evaluate the...

    Authors: Wenshan Lin, Hong-Yan Li, Qian Yang, Guangyong Chen, Shujun Lin, Chunling Liao and Tianbiao Zhou

    Citation: Stem Cell Research & Therapy 2021 12:43

    Content type: Research

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  2. A skin flap is one of the most critical surgical techniques for the restoration of cutaneous defects. However, the distal necrosis of the skin flap severely restricts the clinical application of flap surgery. ...

    Authors: Yuan Li, Qi-lin Jiang, Leanne Van der Merwe, Dong-hao Lou and Cai Lin

    Citation: Stem Cell Research & Therapy 2021 12:28

    Content type: Review

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  3. Acute liver failure (ALF) is an acute inflammatory liver disease with high mortality. Previous preclinical and clinical trials have confirmed that mesenchymal stem cell (MSC) is a promising therapeutic approac...

    Authors: Jinglin Wang, Yang Liu, Haoran Ding, Xiaolei Shi and Haozhen Ren

    Citation: Stem Cell Research & Therapy 2021 12:15

    Content type: Research

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  4. Spinal cord injury (SCI) presents a significant challenge for the field of neurotherapeutics. Stem cells have shown promise in replenishing the cells lost to the injury process, but the release of axon growth-...

    Authors: Benjamin Jevans, Nicholas D. James, Emily Burnside, Conor J. McCann, Nikhil Thapar, Elizabeth J. Bradbury and Alan J. Burns

    Citation: Stem Cell Research & Therapy 2021 12:10

    Content type: Research

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  5. Abnormalities in apoptosis, cell cycle, proliferation, and differentiation of human bone marrow mesenchymal stem cells (hBMSCs) significantly impact bone metabolism and remodeling, resulting in various skeleta...

    Authors: Tao Li, Yingxing Xu, Yingzhen Wang and Yaping Jiang

    Citation: Stem Cell Research & Therapy 2021 12:9

    Content type: Research

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  6. Recent developments in adipose-derived stromal/stem cell (ADSC) biology provide new hopes for tissue engineering and regeneration medicine. Due to their pluripotent activity, paracrine activity, and immunomodu...

    Authors: Jun Fang, Feng Chen, Dong Liu, Feiying Gu and Yuezhen Wang

    Citation: Stem Cell Research & Therapy 2021 12:8

    Content type: Review

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  7. The impressive progress in the field of stem cell research in the past decades has provided the ground for the development of cell-based therapy. Mesenchymal stromal cells obtained from adipose tissue (AD-MSCs...

    Authors: Daisy D. Canepa, Elisa A. Casanova, Eirini Arvaniti, Vinko Tosevski, Sonja Märsmann, Benjamin Eggerschwiler, Sascha Halvachizadeh, Johanna Buschmann, André A. Barth, Jan A. Plock, Manfred Claassen, Hans-Christoph Pape and Paolo Cinelli

    Citation: Stem Cell Research & Therapy 2021 12:7

    Content type: Research

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  8. Multipotent progenitor cells have been harvested from different human tissues, including the bone marrow, adipose tissue, and umbilical cord blood. Previously, we identified a population of mesenchymal progeni...

    Authors: Marvin Dingle, Stephen D. Fernicola, Jaira F. de Vasconcellos, Sonia Zicari, Christopher Daniels, John C. Dunn, Alexander Dimtchev and Leon J. Nesti

    Citation: Stem Cell Research & Therapy 2021 12:6

    Content type: Research

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  9. Parkinson’s disease (PD), the second most common neurodegenerative disease worldwide, is caused by the loss of dopaminergic (DAergic) neurons in the substantia nigra resulting in a series of motor or non-motor...

    Authors: Zhuangzhuang Xiao, Tong Lei, Yanyan Liu, Yanjie Yang, Wangyu Bi and Hongwu Du

    Citation: Stem Cell Research & Therapy 2021 12:5

    Content type: Review

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  10. As one of the main functional forms of mesenchymal stem cells (MSCs), MSC-derived extracellular vesicles (MSC-EVs) have shown an alternative therapeutic option in experimental models of allergic asthma. Oxygen...

    Authors: Liyang Dong, Ying Wang, Tingting Zheng, Yanan Pu, Yongbin Ma, Xin Qi, Wenzhe Zhang, Fei Xue, Zirui Shan, Jiameng Liu, Xuefeng Wang and Chaoming Mao

    Citation: Stem Cell Research & Therapy 2021 12:4

    Content type: Research

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  11. Although pancreatic islet transplantation therapy is ideal for diabetes patients, several hurdles have prevented it from becoming a standard treatment, including donor shortage and low engraftment efficacy. In...

    Authors: Yu Na Lee, Hye-Jin Yi, Eun Hye Seo, Jooyun Oh, Song Lee, Sarah Ferber, Teruo Okano, In Kyong Shim and Song Cheol Kim

    Citation: Stem Cell Research & Therapy 2021 12:3

    Content type: Research

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  12. Cerebral infarction ranks as the second leading cause of disability and death globally, and inflammatory response of glial cells is the main cause of brain damage during cerebral infarction.

    Authors: Guofeng Cai, Guoliang Cai, Haichun Zhou, Zhe Zhuang, Kai Liu, Siying Pei, Yanan Wang, Hong Wang, Xin Wang, Shengnan Xu, Cheng Cui, Manchao Sun, Sihui Guo, Kunping Jia, Xiuzhen Wang and Dianquan Zhang

    Citation: Stem Cell Research & Therapy 2021 12:2

    Content type: Research

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  13. Adipose-derived stem cells (ADSCs) have raised big interest in therapeutic applications in regenerative medicine and appear to fulfill the criteria for a successful cell therapy. Their low immunogenicity and t...

    Authors: Loubna Mazini, Mohamed Ezzoubi and Gabriel Malka

    Citation: Stem Cell Research & Therapy 2021 12:1

    Content type: Review

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  14. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Selami Demirci, Juan J. Haro-Mora, Alexis Leonard, Claire Drysdale, Daniela Malide, Keyvan Keyvanfar, Khaled Essawi, Raul Vizcardo, Naritaka Tamaoki, Nicholas P. Restifo, John F. Tisdale and Naoya Uchida

    Citation: Stem Cell Research & Therapy 2020 11:544

    Content type: Correction

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    The original article was published in Stem Cell Research & Therapy 2020 11:493

  15. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Behnaz Ashtari, Azar Shams, Narges Esmaeilzadeh, Sara Tanbakooei, Morteza Koruji, Mojtaba Johari Moghadam, Javad Mohajer Ansari, Adel Johari Moghadam and Ronak Shabani

    Citation: Stem Cell Research & Therapy 2020 11:543

    Content type: Correction

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    The original article was published in Stem Cell Research & Therapy 2020 11:191

  16. Stem cell transplantation of exogenous neural progenitor cells (NPCs) derived from mesenchymal stem cells (MSCs) has emerged as a promising approach for neurodegenerative disease. Human stem cells from apical ...

    Authors: Anupong Songsaad, Thanasup Gonmanee, Nisarat Ruangsawasdi, Chareerut Phruksaniyom and Charoensri Thonabulsombat

    Citation: Stem Cell Research & Therapy 2020 11:542

    Content type: Research

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  17. Mesenchymal stem cells (MSCs) have exerted their brilliant potential to promote heart repair following myocardial infarction. However, low survival rate of MSCs after transplantation due to harsh conditions wi...

    Authors: Jiaying Fu, Xuxiang Chen, Xin Liu, Daishi Xu, Huan Yang, Chaotao Zeng, Huibao Long, Changqing Zhou, Haidong Wu, Guanghui Zheng, Hao Wu, Wuming Wang and Tong Wang

    Citation: Stem Cell Research & Therapy 2020 11:541

    Content type: Research

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  18. The effects of cryopreservation on human bone marrow-derived mesenchymal stem cells (hBM-MSCs) are still ill-defined. In this study, a quantitative approach was adopted to measure several post-thaw cell attrib...

    Authors: Soukaina Bahsoun, Karen Coopman and Elizabeth C. Akam

    Citation: Stem Cell Research & Therapy 2020 11:540

    Content type: Research

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  19. The paracrine effects of multipotent mesenchymal stromal cells (MSCs) are mediated by their secretome composed by soluble factors (i.e., cytokines, growth factors, hormones) and extracellular vesicles (EVs). E...

    Authors: Anastasia Cheng, Dongsic Choi, Maximilien Lora, Dominique Shum-Tim, Janusz Rak and Inés Colmegna

    Citation: Stem Cell Research & Therapy 2020 11:539

    Content type: Research

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  20. Arteriosclerosis is an age-related disease and a leading cause of cardiovascular disease. In animal experiments, mesenchymal stem cells and its culture-conditioned medium have been shown to be promising tools ...

    Authors: Hiroki Ohta, Xiaolan Liu and Miho Maeda

    Citation: Stem Cell Research & Therapy 2020 11:538

    Content type: Research

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  21. The role of bone tissue engineering is to regenerate tissue using biomaterials and stem cell-based approaches. Combination of two or more cell types is one of the strategies to promote bone formation. Endothel...

    Authors: Chu Xu, Haijie Liu, Yuanjia He, Yuanqing Li and Xiaoning He

    Citation: Stem Cell Research & Therapy 2020 11:537

    Content type: Research

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  22. Skeletal muscle is a complex and heterogeneous tissue accounting for approximately 40% of body weight. Excessive ectopic lipid accumulation in the muscle fascicle would undermine the integrity of skeletal musc...

    Authors: Xin Zhang, Wenjuan Sun, Linjuan He, Liqi Wang, Kai Qiu and Jingdong Yin

    Citation: Stem Cell Research & Therapy 2020 11:536

    Content type: Research

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  23. Tissue engineering is a promising alternative for urethral reconstruction, and adipose-derived stem cells (ADSCs) are widely used as seeding cells. Hypoxia preconditioning can significantly enhance the therape...

    Authors: Xiang Wan, Min-kai Xie, Huan Xu, Zi-wei Wei, Hai-jun Yao, Zhong Wang and Da-chao Zheng

    Citation: Stem Cell Research & Therapy 2020 11:535

    Content type: Research

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  24. Mesenchymal stem/stromal cells can modulate the effector immune cells especially T lymphocytes. Due to this important feature, they can regulate the development of a variety of disorders including inflammatory...

    Authors: Sina Naserian, Sara Shamdani, Nassim Arouche and Georges Uzan

    Citation: Stem Cell Research & Therapy 2020 11:534

    Content type: Short report

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  25. Biological composite scaffolds are increasingly being used in abdominal wall reconstruction but still have certain shortcomings. The present study describes here a novel three-dimensional (3D) scaffold fabrica...

    Authors: Zhi Yang, Zhicheng Song, Xin Nie, Kaijin Guo and Yan Gu

    Citation: Stem Cell Research & Therapy 2020 11:533

    Content type: Research

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  26. Human mesenchymal stromal cells (MSC) hold hopes for cartilage regenerative therapy due to their chondrogenic differentiation potential. However, undesirable occurrence of calcification after ectopic transplan...

    Authors: Svitlana Melnik, Jessica Gabler, Simon I. Dreher, Nicole Hecht, Nina Hofmann, Tobias Großner and Wiltrud Richter

    Citation: Stem Cell Research & Therapy 2020 11:532

    Content type: Research

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  27. Human dental pulp stromal cells (hDPSCs) are promising sources of mesenchymal stem cells (MSCs) for bone tissue regeneration. Circular RNAs (circRNAs) have been demonstrated to play critical roles in stem cell...

    Authors: Bo Zhang, Sibei Huo, Xiao Cen, Xuefeng Pan, Xinqi Huang and Zhihe Zhao

    Citation: Stem Cell Research & Therapy 2020 11:531

    Content type: Research

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  28. Chronic kidney disease (CKD) is a global public health problem. Cell therapy using pluripotent stem cells represents an attractive therapeutic approach for the treatment of CKD.

    Authors: Patrícia de Carvalho Ribeiro, Fernando Henrique Lojudice, Ida Maria Maximina Fernandes-Charpiot, Maria Alice Sperto Ferreira Baptista, Stanley de Almeida Araújo, Gloria Elisa Florido Mendes, Mari Cleide Sogayar, Mario Abbud-Filho and Heloisa Cristina Caldas

    Citation: Stem Cell Research & Therapy 2020 11:530

    Content type: Research

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  29. During development, excessive osteogenic differentiation of mesenchymal progenitor cells (MPC) within the cranial sutures can lead to premature suture fusion or craniosynostosis, leading to craniofacial and co...

    Authors: Clara Pribadi, Esther Camp, Dimitrios Cakouros, Peter Anderson, Carlotta Glackin and Stan Gronthos

    Citation: Stem Cell Research & Therapy 2020 11:529

    Content type: Research

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  30. Ectopic expression of a defined set of transcription factors allows the reprogramming of mammalian somatic cells to pluripotency. Despite continuous progress in primate and rodent reprogramming, limited attent...

    Authors: Ian C. Tobias, Mian-Mian C. Kao, Thomas Parmentier, Hailey Hunter, Jonathan LaMarre and Dean H. Betts

    Citation: Stem Cell Research & Therapy 2020 11:528

    Content type: Research

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  31. The transplantation of human umbilical cord blood (UCB) CD34+ cells has been successfully used to treat hematological disorders but one major limitation has been the low cell numbers available. Mesenchymal ste...

    Authors: Hao Daniel Lin, Chui-Yee Fong, Arijit Biswas and Ariff Bongso

    Citation: Stem Cell Research & Therapy 2020 11:527

    Content type: Research

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  32. Bone marrow mesenchymal stem cell (BM-MSC) has been shown to treat pulmonary arterial hypertension (PAH). However, excessive reactive oxygen species (ROS) increases the apoptosis of BM-MSCs, leading to poor su...

    Authors: Qian Zhang, Xianfeng Cheng, Haizhou Zhang, Tao Zhang, Zhengjun Wang, Wenlong Zhang and Wancheng Yu

    Citation: Stem Cell Research & Therapy 2020 11:526

    Content type: Research

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  33. Mesenchymal stem cells (MSCs) were shown to harbor therapeutic potential in models of respiratory diseases, such as bronchopulmonary dysplasia (BPD), the most common sequel of preterm birth. In these studies, ...

    Authors: Janine Obendorf, Claire Fabian, Ulrich H. Thome and Mandy Laube

    Citation: Stem Cell Research & Therapy 2020 11:525

    Content type: Research

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  34. The efficacy of mesenchymal stromal cell (MSC) therapy is thought to depend on the intrinsic heterogeneity of MSC cultures isolated from different tissue sources as well as individual MSCs isolated from the sa...

    Authors: Rebecca M. Harman, Roosheel S. Patel, Jennifer C. Fan, Jee E. Park, Brad R. Rosenberg and Gerlinde R. Van de Walle

    Citation: Stem Cell Research & Therapy 2020 11:524

    Content type: Research

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  35. The corneal endothelium located on the posterior corneal surface is responsible for regulating stromal hydration. This is contributed by a monolayer of corneal endothelial cells (CECs), which are metabolically...

    Authors: Nicole Ming Sie, Gary Hin-Fai Yam, Yu Qiang Soh, Matthew Lovatt, Deepinder Dhaliwal, Viridiana Kocaba and Jodhbir S. Mehta

    Citation: Stem Cell Research & Therapy 2020 11:523

    Content type: Review

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  36. The physical factors of the extracellular matrix have a profound influence on the differentiation behavior of mesenchymal stem cells. In this study, the effect of the biophysical microenvironment on rat bone m...

    Authors: Yuchao Yang, Yanting Feng, Rongmei Qu, Qingtao Li, Dongming Rong, Tingyu Fan, Yiting Yang, Bing Sun, Zhenyu Bi, Asmat Ullah Khan, Ting Deng, Jingxing Dai and Jun Ouyang

    Citation: Stem Cell Research & Therapy 2020 11:522

    Content type: Research

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  37. In the last years, several clinical trials have proved the safety and efficacy of adipose-derived stem/stromal cells (ASC) in contrasting osteoarthritis (OA). Since ASC act mainly through paracrine mechanisms,...

    Authors: Chiara Giannasi, Stefania Niada, Cinzia Magagnotti, Enrico Ragni, Annapaola Andolfo and Anna Teresa Brini

    Citation: Stem Cell Research & Therapy 2020 11:521

    Content type: Research

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  38. Accumulating evidence indicates that mesenchymal stem cells (MSCs) exert tissue repair effects and therapeutic angiogenesis through their noncoding RNAs (ncRNAs). Our previous studies showed that MSCs derived ...

    Authors: Qin Shi, Baolan Sun, Di Wang, Yi Zhu, Xinxin Zhao, Xiaoqing Yang and Yuquan Zhang

    Citation: Stem Cell Research & Therapy 2020 11:520

    Content type: Research

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  39. Human umbilical cord mesenchymal stem cells (HUC-MSCs) present in the umbilical cord tissue are self-renewing and multipotent. They can renew themselves continuously and, under certain conditions, differentiat...

    Authors: Qixin Xie, Rui Liu, Jia Jiang, Jing Peng, Chunyan Yang, Wen Zhang, Sheng Wang and Jing Song

    Citation: Stem Cell Research & Therapy 2020 11:519

    Content type: Review

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  40. To investigate the odonto-immunomodulatory properties of dental pulp stem cell-derived small extracellular vesicles (DPSCs-sEV), which promote odontogenesis by switching macrophages toward the pro-healing M2 p...

    Authors: Jianmao Zheng, Yuanyuan Kong, Xiaoli Hu, Zhishan Li, Yaoyin Li, Yingqun Zhong, Xi Wei and Junqi Ling

    Citation: Stem Cell Research & Therapy 2020 11:517

    Content type: Research

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  41. Bone destruction is a hallmark of multiple myeloma (MM). It has been reported that proteasome inhibitors (PIs) can reduce bone resorption and increase bone formation in MM patients, but the underlying mechanis...

    Authors: Dan Zhang, Kim De Veirman, Rong Fan, Qiang Jian, Yuchen Zhang, Li Lei, Holly Evans, Yanmeng Wang, Lei Lei, Baiyan Wang, Ramone A. Williamson, Andrew Chantry, Pengcheng He, Ang Li, Hendrik De Raeve, Karin Vanderkerken…

    Citation: Stem Cell Research & Therapy 2020 11:516

    Content type: Research

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  42. Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global pandemic. The prevalence/severity of COVID-19 is higher among patients with cardiovasc...

    Authors: Youjeong Kwon, Sarath Babu Nukala, Shubhi Srivastava, Hiroe Miyamoto, Nur Izzah Ismail, Jordan Jousma, Jalees Rehman, Sang-Bing Ong, Won Hee Lee and Sang-Ging Ong

    Citation: Stem Cell Research & Therapy 2020 11:514

    Content type: Letter

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  43. The present study compared the effects of antifibrotic medications, pirfenidone, and nintedanib, with transplantation of human umbilical mesenchymal stem cells (HUMSCs) in restoring rat pulmonary fibrosis (PF).

    Authors: Kuo-An Chu, Chang-Ching Yeh, Fu-Hsien Kuo, Wen-Ren Lin, Chien-Wei Hsu, Tien-Hua Chen and Yu-Show Fu

    Citation: Stem Cell Research & Therapy 2020 11:513

    Content type: Research

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  44. Mesenchymal stem cell (MSC)-derived exosomes have shown comprehensive application prospects over the years. Despite performing similar functions, exosomes from different origins present heterogeneous character...

    Authors: Zheng-gang Wang, Zhi-yi He, Shuang Liang, Qing Yang, Peng Cheng and An-min Chen

    Citation: Stem Cell Research & Therapy 2020 11:511

    Content type: Research

    Published on:

  45. Stem cell therapies represent a promising tool in regenerative medicine. Considering the drawbacks of direct stem cell injections (e.g. poor cell localisation), extracellular matrix-based biomaterials (e.g. sc...

    Authors: Héctor Capella-Monsonís, Andrea De Pieri, Rita Peixoto, Stefanie Korntner and Dimitrios I. Zeugolis

    Citation: Stem Cell Research & Therapy 2020 11:510

    Content type: Research

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  46. As the major interface between the body and the external environment, the skin is liable to various injuries. Skin injuries often lead to severe disability, and the exploration of promising therapeutic strateg...

    Authors: Jin Liu, Xinyu Qiu, Yajie Lv, Chenxi Zheng, Yan Dong, Geng Dou, Bin Zhu, Anqi Liu, Wei Wang, Jun Zhou, Siying Liu, Shiyu Liu, Bo Gao and Yan Jin

    Citation: Stem Cell Research & Therapy 2020 11:507

    Content type: Research

    Published on:

  47. Despite years of research, porcine-induced pluripotent stem cells (piPSCs) with germline chimeric capacity have not been established. Furthermore, the key transcription factors (TFs) defining the naïve state i...

    Authors: Bingbo Shi, Dengfeng Gao, Liang Zhong, Minglei Zhi, Xiaogang Weng, Junjun Xu, Junhong Li, Xuguang Du, Yanli Xin, Jie Gao, Qianqian Zhu, Suying Cao, Zhonghua Liu and Jianyong Han

    Citation: Stem Cell Research & Therapy 2020 11:505

    Content type: Research

    Published on:

  48. De novo mutations (DNMs) have been implicated in the etiology of schizophrenia (SZ), a chronic debilitating psychiatric disorder characterized by hallucinations, delusions, cognitive dysfunction, and decreased...

    Authors: Edit Hathy, Eszter Szabó, Nóra Varga, Zsuzsa Erdei, Csongor Tordai, Boróka Czehlár, Máté Baradits, Bálint Jezsó, Júlia Koller, László Nagy, Mária Judit Molnár, László Homolya, Zsófia Nemoda, Ágota Apáti and János M. Réthelyi

    Citation: Stem Cell Research & Therapy 2020 11:504

    Content type: Research

    Published on:

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