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  1. Radiation-induced lung injury (RILI) is considered one of the most common complications of thoracic radiation. Recent studies have focused on stem cell properties to obtain ideal therapeutic effects, and Sox9 ...

    Authors: Shuang Chen, Kang Li, Xinqi Zhong, Ganping Wang, Xiaocheng Wang, Maosheng Cheng, Jie Chen, Zhi Chen, Jianwen Chen, Caihua Zhang, Gan Xiong, Xiuyun Xu, Demeng Chen, Heping Li and Liang Peng

    Citation: Stem Cell Research & Therapy 2021 12:381

    Content type: Research

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  2. Small blood stem cells (SB cells), isolated from human peripheral blood, demonstrated the ability to benefit bone regeneration and osseointegration. The primary goal of our study is to examine the safety and t...

    Authors: Sheng-Wei Feng, Yi-Han Su, Yen-Kuang Lin, Yu-Chih Wu, Yen-Hua Huang, Fu-Hung Yang, Hsi-Jen Chiang, Yun Yen and Peter Da-Yen Wang

    Citation: Stem Cell Research & Therapy 2021 12:380

    Content type: Research

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  3. Embryonic stem cell-derived extracellular vesicles (ESC-EVs) possess therapeutic potential for a variety of diseases and are considered as an alternative of ES cells. Acute kidney injury (AKI) is a common acut...

    Authors: Lu Yu, Siying Liu, Chen Wang, Chuanyu Zhang, Yajie Wen, Kaiyue Zhang, Shang Chen, Haoyan Huang, Yue Liu, Lingling Wu, Zhongchao Han, Xiangmei Chen, Zongjin Li and Na Liu

    Citation: Stem Cell Research & Therapy 2021 12:379

    Content type: Research

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  4. Idiopathic pneumonia syndrome (IPS) is a non-infectious fatal complication characterized by a massive infiltration of leukocytes in lungs and diffuse pulmonary injury after allogeneic hematopoietic stem cell t...

    Authors: Min Cao, Huihui Liu, Yujun Dong, Wei Liu, Zhengyu Yu, Qingya Wang, Qingyun Wang, Zeying Liang, Yuan Li and Hanyun Ren

    Citation: Stem Cell Research & Therapy 2021 12:378

    Content type: Research

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  5. There is a huge controversy about whether xenograft or allograft in the “immune-privileged” brain needs immunosuppression. In animal studies, the prevailing sophisticated use of immunosuppression or immunodefi...

    Authors: Chunhua Liu, Xiaoyun Wang, Wenhao Huang, Wei Meng, Zhenghui Su, Qi Xing, Heng Shi, Di Zhang, Min Zhou, Yifan Zhao, Haitao Wang, Guangjin Pan, Xiaofen Zhong, Duanqing Pei and Yiping Guo

    Citation: Stem Cell Research & Therapy 2021 12:376

    Content type: Research

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  6. Direct reprogramming of human fibroblasts to hepatocyte-like cells was proposed to generate large-scale functional hepatocytes demanded by liver tissue engineering. However, the difficulty in obtaining large q...

    Authors: Jie Deng, Kai Luo, Pengchao Xu, Qingyuan Jiang, Yuan Wang, Yunqi Yao, Xiaolei Chen, Fuyi Cheng, Dan Xie and Hongxin Deng

    Citation: Stem Cell Research & Therapy 2021 12:375

    Content type: Research

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  7. Adoptive cell therapy has received a great deal of interest in the treatment of advanced cancers that are resistant to traditional therapy. The tremendous success of chimeric antigen receptor (CAR)-engineered ...

    Authors: Faroogh Marofi, Marwan Mahmood Saleh, Heshu Sulaiman Rahman, Wanich Suksatan, Moaed E. Al-Gazally, Walid Kamal Abdelbasset, Lakshmi Thangavelu, Alexei Valerievich Yumashev, Ali Hassanzadeh, Mahboubeh Yazdanifar, Roza Motavalli, Yashwant Pathak, Adel Naimi, Behzad Baradaran, Marzieh Nikoo and Farhad Motavalli Khiavi

    Citation: Stem Cell Research & Therapy 2021 12:374

    Content type: Review

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  8. Even though the manufacturing processes of the stromal vascular fraction for clinical use are performed in compliance with the good manufacturing practices applying to advanced therapy medicinal products, spec...

    Authors: Pauline François, Giulio Rusconi, Laurent Arnaud, Luca Mariotta, Laurent Giraudo, Greta Minonzio, Julie Veran, Baptiste Bertrand, Chloé Dumoulin, Fanny Grimaud, Luc Lyonnet, Dominique Casanova, Camille Giverne, Audrey Cras, Guy Magalon, Françoise Dignat-George…

    Citation: Stem Cell Research & Therapy 2021 12:373

    Content type: Research

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  9. Manipulation of neural stem and progenitor cells (NSPCs) is critical for the successful treatment of spinal cord injury (SCI) by NSPC transplantation, since their differentiation into neurons and oligodendrocy...

    Authors: Chen-Guang Zhao, Jie Qin, Jia Li, Shan Jiang, Fen Ju, Wei Sun, Zhen Ren, Yu-Qiang Ji, Rui Wang, Xiao-Long Sun, Xiang Mou and Hua Yuan

    Citation: Stem Cell Research & Therapy 2021 12:372

    Content type: Research

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  10. This study tested the hypothesis that double overexpression of miR-19a and miR-20a (dOex-mIRs) in human induced pluripotent stem cell (iPS)-derived mesenchymal stem cells (MSCs) effectively preserved left vent...

    Authors: Jiunn-Jye Sheu, Han-Tan Chai, Pei-Hsun Sung, John Y. Chiang, Tien-Hung Huang, Pei-Lin Shao, Shun-Cheng Wu and Hon-Kan Yip

    Citation: Stem Cell Research & Therapy 2021 12:371

    Content type: Research

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  11. This study tested the hypothesis that combined melatonin (Mel) and adipose-derived mesenchymal stem cells (ADMSCs) treatment was superior to either one alone on protecting the testis against acute testicular t...

    Authors: Yen-Ta Chen, Fei-Chi Chuang, Chih-Chao Yang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Chi-Ruei Huang, Kuan-Hui Huang and Hon-Kan Yip

    Citation: Stem Cell Research & Therapy 2021 12:370

    Content type: Research

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  12. The cerebellum is the sensitive region of the brain to developmental abnormalities related to the effects of oxidative stresses. Abnormal cerebellar lobe formation, found in Jun dimerization protein 2 (Jdp2)-knoc...

    Authors: Chia-Chen Ku, Kenly Wuputra, Kohsuke Kato, Jia-Bin Pan, Chia-Pei Li, Ming-Ho Tsai, Michiya Noguchi, Yukio Nakamura, Chung-Jung Liu, Te-Fu Chan, Ming-Feng Hou, Shigeharu Wakana, Yang-Chang Wu, Chang-Shen Lin, Deng-Chyang Wu and Kazunari K. Yokoyama

    Citation: Stem Cell Research & Therapy 2021 12:369

    Content type: Research

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  13. The activation of T cells and imbalanced redox metabolism enhances the development of graft-versus-host disease (GVHD). Human placenta-derived mesenchymal stromal cells (hPMSCs) can improve GVHD through regula...

    Authors: Aiping Zhang, Jiashen Zhang, Xiaohua Li, Hengchao Zhang, Yanlian Xiong, Zhuoya Wang, Nannan Zhao, Feifei Wang and Xiying Luan

    Citation: Stem Cell Research & Therapy 2021 12:368

    Content type: Research

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  14. Acute kidney injury (AKI) is an emerging global healthcare issue without effective therapy yet. Autophagy recycles damaged organelles and helps maintain tissue homeostasis in acute renal ischemia-reperfusion (...

    Authors: Wei-Cheng Tseng, Pei-Ying Lee, Ming-Tsun Tsai, Fu-Pang Chang, Nien-Jung Chen, Chiang-Ting Chien, Shih-Chieh Hung and Der-Cherng Tarng

    Citation: Stem Cell Research & Therapy 2021 12:367

    Content type: Research

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  15. Stem cells are the main choice for seed cells in tissue engineering, but using most traditional stem cells requires invasive and complicated procedures. Human urine-derived stem cells (hUSCs) are an alternativ...

    Authors: Jiachen Sun, Fei Xing, Min Zou, Min Gong, Lang Li and Zhou Xiang

    Citation: Stem Cell Research & Therapy 2021 12:366

    Content type: Research

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  16. State-of-the-art advances have indicated the pivotal characteristics of bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) in hematopoietic microenvironment as well as coordinate contribution to hema...

    Authors: Leisheng Zhang, Ying Chi, Yimeng Wei, Wenxia Zhang, Fuxu Wang, Lei Zhang, Linglin Zou, Baoquan Song, Xing Zhao and Zhongchao Han

    Citation: Stem Cell Research & Therapy 2021 12:365

    Content type: Research

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  17. Obesity is a metabolic disorder syndrome characterized by excessive fat accumulation that is related to many diseases. Human amniotic mesenchymal stem cells (hAMSCs) have a great potential for cell-based thera...

    Authors: Hui-Lan Tan, Xiao-Hui Guan, Min Hu, Jie Wu, Rong-Zhen Li, Ling-Fang Wang, Hou-Da Huang, Zhen-Ping Yu, Xiao-Yu Wang, Yun-Fei Xiao, Ke-Yu Deng and Hong-Bo Xin

    Citation: Stem Cell Research & Therapy 2021 12:364

    Content type: Research

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  18. Overall, 5–10% of fractures result in delayed unions or non-unions, causing major disabilities and a huge socioeconomic burden. Since rescue surgery with autologous bone grafts can cause additional challenges,...

    Authors: Marc Jayankura, Arndt Peter Schulz, Olivier Delahaut, Richard Witvrouw, Lothar Seefried, Bruno Vande Berg, Guy Heynen and Wendy Sonnet

    Citation: Stem Cell Research & Therapy 2021 12:363

    Content type: Research

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  19. Vitamin B3 (nicotinamide) plays important roles in metabolism as well as in SIRT and PARP pathways. It is also recently reported as a novel kinase inhibitor with multiple targets. Nicotinamide promotes pancrea...

    Authors: Yumeng Zhang, Jiaqi Xu, Zhili Ren, Ya Meng, Weiwei Liu, Ligong Lu, Zhou Zhou and Guokai Chen

    Citation: Stem Cell Research & Therapy 2021 12:362

    Content type: Short report

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  20. While existing remedies failed to fully address the consequences of heart failure, stem cell therapy has been introduced as a promising approach. The present review is a comprehensive appraisal of the impacts ...

    Authors: Iman Razeghian-Jahromi, Anthony G. Matta, Ronan Canitrot, Mohammad Javad Zibaeenezhad, Mahboobeh Razmkhah, Anahid Safari, Vanessa Nader and Jerome Roncalli

    Citation: Stem Cell Research & Therapy 2021 12:361

    Content type: Review

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  21. Mesenchymal stem or stromal cells are the most widely used cell therapy to date. They are heterogeneous, with variations in growth potential, differentiation capacity and protein expression profile depending o...

    Authors: Alison J. Wilson, Emma Rand, Andrew J. Webster and Paul G. Genever

    Citation: Stem Cell Research & Therapy 2021 12:360

    Content type: Research

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  22. To investigate the heterogeneities of human umbilical cord mesenchymal stromal cells (HUCMSCs) derived from different donors and their therapeutic variations when applied to mouse liver fibrosis model.

    Authors: Yuanyuan Xie, Shuo Liu, Liudi Wang, Hui Yang, Chenxu Tai, Li Ling, Libo Chen, Shanshan Liu and Bin Wang

    Citation: Stem Cell Research & Therapy 2021 12:359

    Content type: Research

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  23. We show previously that three-dimensional (3D) spheroid cultured mesenchymal stem cells (MSCs) exhibit reduced cell size thus devoid of lung entrapment following intravenous (IV) infusion. In this study, we de...

    Authors: Yuejiao Li, Yankai Dong, Ye Ran, Yanan Zhang, Boyao Wu, Jundong Xie, Yanpei Cao, Miaohua Mo, Sen Li, Hao Deng, Wenbo Hao, Shengyuan Yu and Yaojiong Wu

    Citation: Stem Cell Research & Therapy 2021 12:358

    Content type: Research

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  24. The dentin–pulp complex is essential for the long-term integrity and viability of teeth but it is susceptible to damage caused by external factors. Because traditional approaches for preserving the dentin–pulp...

    Authors: Zixia Li, Liu Liu, Liu Wang and Dongzhe Song

    Citation: Stem Cell Research & Therapy 2021 12:357

    Content type: Review

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  25. It is known that in countries, in which basic research on human embryos is in fact prohibited by law, working with imported human embryonic stem cells (hESCs) can still be permitted. As long as hESCs are not c...

    Authors: Markus Hengstschläger and Margit Rosner

    Citation: Stem Cell Research & Therapy 2021 12:356

    Content type: Commentary

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  26. The adverse health effects of fine particulate matter (PM2.5) exposure are associated with marked inflammatory responses. Adipose-derived stem cells (ADSCs) have immunosuppressive effects, and ADSC transplantatio...

    Authors: Junling Gao, Juntao Yuan, Qun Liu, Yuanli Wang, Huiwen Wang, Yingjie Chen, Wenjun Ding, Guangju Ji and Zhongbing Lu

    Citation: Stem Cell Research & Therapy 2021 12:355

    Content type: Research

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  27. Treatment of avascular necrosis of the femoral head (ANFH) in young patients remains a clinical challenge. A current controversy is whether hip-preserving surgery results in better outcomes. The adverse effect...

    Authors: Qingtian Li, Weihong Liao, Guangtao Fu, Junxing Liao, Ruiying Zhang, Mengyuan Li, Yuhui Yang, Yuanchen Ma, Minghao Zheng and Qiujian Zheng

    Citation: Stem Cell Research & Therapy 2021 12:354

    Content type: Research

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  28. Decades of efforts have attempted to differentiate the pluripotent stem cells (PSCs) into truly functional hematopoietic stem cells (HSCs), yet the problems of low differentiation efficiency in vitro and poor ...

    Authors: Wei Shan, Qin Yu, Yan Long, Qian Luo, Honghu Li, Yingli Han, Yulin Xu, Shan Fu, Xiangjun Zeng, Cong Wei, Yang Gao, Xiaoqing Li, Xia Li, Lifei Zhang, Lizhen Liu, Ming Chen…

    Citation: Stem Cell Research & Therapy 2021 12:353

    Content type: Research

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  29. Hearing loss affects 25% of the population at ages 60–69 years. Loss of the hair cells of the inner ear commonly underlies deafness and once lost this cell type cannot spontaneously regenerate in higher verteb...

    Authors: Hiroki Takeda, Anna Dondzillo, Jessica A. Randall and Samuel P. Gubbels

    Citation: Stem Cell Research & Therapy 2021 12:352

    Content type: Research

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  30. Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system capable of immune surveillance. Given their ability to rapidly and effectively recognize and kill aberrant cells, especially tran...

    Authors: Gabrielle M. Robbins, Minjing Wang, Emily J. Pomeroy and Branden S. Moriarity

    Citation: Stem Cell Research & Therapy 2021 12:350

    Content type: Review

    Published on:

  31. Glioma is one of the most common central nervous system malignant tumors, accounting for 45~60% of adult intracranial tumors. However, the clinical treatment of glioma is limited. It is of great significance t...

    Authors: Ruijie Zhang, Peng Li, Heli Lv, Nana Li, Suliang Ren and Wentao Xu

    Citation: Stem Cell Research & Therapy 2021 12:349

    Content type: Research

    Published on:

  32. Patients with osteoporosis have a high risk of implant loosening due to poor osteointegration, possibly leading to implant failure, implant revision, and refracture. RNA interference therapy is an emerging epi...

    Authors: Wei Liu, Jinghuan Huang, Feng Chen, Dong Xie, Longqing Wang, Cheng Ye, Qi Zhu, Xiang Li, Xiaolin Li and Lili Yang

    Citation: Stem Cell Research & Therapy 2021 12:348

    Content type: Research

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  33. Human bone marrow-derived mesenchymal stem cells (hBMSCs) can differentiate into adipocytes upon stimulation and are considered an appropriate cell source for adipose tissue engineering. In addition to biochem...

    Authors: Shiqi Xiang, Zhong Li, Madalyn R. Fritch, La Li, Sachin Velankar, Yuwei Liu, Jihee Sohn, Natasha Baker, Hang Lin and Rocky S. Tuan

    Citation: Stem Cell Research & Therapy 2021 12:347

    Content type: Research

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  34. The human skin-derived precursors (SKPs) are a good cell source for regeneration. However, the isolation of SKP from human skin is limited. To overcome this drawback, we hypothesized that the component of plan...

    Authors: Yoo-Wook Kwon, Shin-Hyae Lee, Ah-Reum Kim, Beom Joon Kim, Won-Seok Park, Jin Hur, Hyunduk Jang, Han-Mo Yang, Hyun-Jai Cho and Hyo-Soo Kim

    Citation: Stem Cell Research & Therapy 2021 12:346

    Content type: Research

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  35. Adult hippocampal neurogenesis (AHN) is restricted under the pathological conditions of neurodegenerative diseases, especially in Alzheimer’s disease (AD). The drop of AHN reduces neural circuit plasticity, re...

    Authors: Xiaolei Wu, Qi Shen, Zhan Zhang, Di Zhang, Ying Gu and Da Xing

    Citation: Stem Cell Research & Therapy 2021 12:345

    Content type: Research

    Published on:

  36. The human endometrium in premenopausal women is an active site of physiological angiogenesis, with regenerative cells present, suggesting that the endometrium contains adult angiogenic stem cells. In the conte...

    Authors: Xuemei Fan, Sheng He, Huifang Song, Wenjuan Yin, Jie Zhang, Zexu Peng, Kun Yang, Xiaoyan Zhai, Lingxia Zhao, Hui Gong, Yi Ping, Xiangying Jiao, Sanyuan Zhang, Changping Yan, Hongliang Wang, Ren-Ke Li…

    Citation: Stem Cell Research & Therapy 2021 12:344

    Content type: Research

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  37. The liver possesses a powerful regeneration ability, which is correlated with the stemness of hepatocytes in the portal vein (PV). However, the mechanism underlying the maintenance of hepatocyte stemness has n...

    Authors: Changchun Shao, Xue Yang, Yingying Jing, Xiaojuan Hou, Yihua Huang, Chen Zong, Lu Gao, Wenting Liu, Jinghua Jiang, Fei Ye, Junxia Shi, Qiudong Zhao, Rong Li, Xiaoren Zhang and Lixin Wei

    Citation: Stem Cell Research & Therapy 2021 12:342

    Content type: Research

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  38. Epidermal stem cells (EpSCs) play a vital role in wound healing and skin renewal. Although biomaterial scaffolds have been used for transplantation of EpSCs in wound healing, the ex vivo differentiation of EpS...

    Authors: Zhixiao Lin, Congying Zhao, Zhanjun Lei, Yuheng Zhang, Rong Huang, Bin Lin, Yuchen Dong, Hao Zhang, Jinqing Li and Xueyong Li

    Citation: Stem Cell Research & Therapy 2021 12:341

    Content type: Research

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  39. The preservation or restoration of β cell function in type 1 diabetes (T1D) remains as an attractive and challengeable therapeutic target. Mesenchymal stromal cells (MSCs) are multipotent cells with high capac...

    Authors: Jing Lu, Shan-mei Shen, Qing Ling, Bin Wang, Li-rong Li, Wei Zhang, Duo-duo Qu, Yan Bi and Da-long Zhu

    Citation: Stem Cell Research & Therapy 2021 12:340

    Content type: Research

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  40. The spatiotemporal regulation of essential genes is crucial for controlling the growth and differentiation of cells in a precise manner during regeneration. Recently, optogenetics was considered as a potent te...

    Authors: Delan Huang, Runze Li, Jianhan Ren, Haotian Luo, Weicai Wang and Chen Zhou

    Citation: Stem Cell Research & Therapy 2021 12:339

    Content type: Research

    Published on:

  41. The use of adipose-derived mesenchymal stromal cell-derived exosomes (ADSC-Exos) may become a new therapeutic method in biomedicine owing to their important role in regenerative medicine. However, the role of ...

    Authors: Hengchen Liu, Mingzhao Zhang, Manyu Shi, Tingting Zhang, Wenjun Lu, Shulong Yang, Qingbo Cui and Zhaozhu Li

    Citation: Stem Cell Research & Therapy 2021 12:338

    Content type: Research

    Published on:

  42. Mesenchymal stem cells (MSCs) hold promising potential to treat systemic inflammatory diseases including severe acute pancreatitis (SAP). In our previous study, placental chorionic plate-derived MSCs (CP-MSCs)...

    Authors: Qilin Huang, Xiumei Cheng, Chen Luo, Shuxu Yang, Shuai Li, Bing Wang, Xiaohui Yuan, Yi Yang, Yi Wen, Ruohong Liu, Lijun Tang and Hongyu Sun

    Citation: Stem Cell Research & Therapy 2021 12:337

    Content type: Research

    Published on:

  43. Intra-bone marrow injection (IBMI) in rats is adopted in many studies for stem cell and hematopoietic cell transplantation. IBMI in the tibia or the femur results in severe distress to the animal. Therefore, t...

    Authors: Marwa S. Khattab, Huda O. AbuBakr, Kassem G. El Iraqi, Naglaa A. AbdElKader, Mervat M. Kamel, Khaled Hamed Salem, Julia Steitz and Mamdouh Afify

    Citation: Stem Cell Research & Therapy 2021 12:336

    Content type: Research

    Published on:

  44. Loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) underlines much of the pathology of Parkinson’s disease (PD), but the existence of an endogenous neurogenic system that could be target...

    Authors: Theodora Mourtzi, Dimitrios Dimitrakopoulos, Dimitrios Kakogiannis, Charalampos Salodimitris, Konstantinos Botsakis, Danai Kassandra Meri, Maria Anesti, Aggeliki Dimopoulou, Ioannis Charalampopoulos, Achilleas Gravanis, Nikolaos Matsokis, Fevronia Angelatou and Ilias Kazanis

    Citation: Stem Cell Research & Therapy 2021 12:335

    Content type: Research

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  45. How to obtain a small interfering RNA (siRNA) vector has become a moot point in recent years. Exosomes (Exo) show advantages of long survival time in vivo, high transmission efficiency, and easy penetration ac...

    Authors: Wei Huang, Mingjia Qu, Lu Li, Tao Liu, Miaoman Lin and Xiaobing Yu

    Citation: Stem Cell Research & Therapy 2021 12:334

    Content type: Research

    Published on:

  46. Renal fibrosis commonly leads to glomerulosclerosis and renal interstitial fibrosis and the main pathological basis involves tubular atrophy and the abnormal increase and excessive deposition of extracellular ...

    Authors: Yiping Liu, Yan-Yan Su, Qian Yang and Tianbiao Zhou

    Citation: Stem Cell Research & Therapy 2021 12:333

    Content type: Review

    Published on:

  47. Complement factor H (FH) is the main plasma regulator of the alternative pathway of complement. Genetic and acquired abnormalities in FH cause uncontrolled complement activation amplifying, with the consequent...

    Authors: Federica Casiraghi, Pamela Yossenaidy Rodriguez Ordonez, Nadia Azzollini, Marta Todeschini, Daniela Rottoli, Roberta Donadelli, Roberto Gramignoli, Ariela Benigni, Marina Noris and Giuseppe Remuzzi

    Citation: Stem Cell Research & Therapy 2021 12:332

    Content type: Short report

    Published on:

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