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  1. Human exposure to high doses of radiation resulting in acute radiation syndrome and death can rapidly escalate to a mass casualty catastrophe in the event of nuclear accidents or terrorism. The primary reason ...

    Authors: Alison Accarie, Bruno l’Homme, Mohamed Amine Benadjaoud, Sai Kiang Lim, Chandan Guha, Marc Benderitter, Radia Tamarat and Alexandra Sémont

    Citation: Stem Cell Research & Therapy 2020 11:371

    Content type: Research

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  2. The stem cell is the foundation of regenerative medicine and tissue engineering. Regulating specific stem cell fate, such as cell attachment, proliferation, differentiation, and even death, undergoes continuou...

    Authors: Fei Tan, Yin Fang, Liwei Zhu and Mohamed Al-Rubeai

    Citation: Stem Cell Research & Therapy 2020 11:368

    Content type: Review

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  3. Malaria is one of the most critical global infectious diseases. Severe systemic inflammatory diseases, such as cerebral malaria, lead to the development of cognitive and behavioral alterations, such as learnin...

    Authors: Maiara N. Lima, Helena A. Oliveira, Paula M. Fagundes, Vanessa Estato, Adriano Y. O. Silva, Rodrigo J. R. X. Freitas, Beatriz A. B. R. Passos, Karina S. Oliveira, Camila N. Batista, Adriana L. Vallochi, Patricia R. M. Rocco, Hugo C. Castro-Faria-Neto and Tatiana Maron-Gutierrez

    Citation: Stem Cell Research & Therapy 2020 11:367

    Content type: Research

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  4. Significant progress has been made in cell replacement therapy for neural retinal diseases using retinal cells differentiated from human pluripotent stem cells. Low tumorigenicity and the ability to mature to ...

    Authors: Deng Pan, Xi-Xi Xia, Heng Zhou, Si-Qian Jin, Yang-Yan Lu, Hui Liu, Mei-Ling Gao and Zi-Bing Jin

    Citation: Stem Cell Research & Therapy 2020 11:366

    Content type: Research

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  5. Transfer RNA-derived small RNAs (tsRNAs) are a recently discovered form of non-coding RNA capable of regulating myriad physiological processes. The role of tsRNAs in hMSC adipogenic differentiation, however, r...

    Authors: Tao Wang, Jun Mei, Xingnuan Li, Xiaoyuan Xu, Baicheng Ma and Weidong Li

    Citation: Stem Cell Research & Therapy 2020 11:365

    Content type: Research

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  6. Bone regeneration is preferred for bone loss caused by tumors, bone defects, fractures, etc. Recently, mesenchymal stem cells are considered as optimistic tools for bone defect therapy. Dental pulp stem cells ...

    Authors: Xingyun Ge, Zehan Li, Zhou Zhou, Yibo Xia, Minxia Bian and Jinhua Yu

    Citation: Stem Cell Research & Therapy 2020 11:364

    Content type: Research

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  7. Chronic low back pain is a prevalent disability, often caused by intervertebral disc (IVD) degeneration. Mesenchymal stem cell (MSC) therapy could be a safe and feasible option for repairing the degenerated di...

    Authors: Manjunatha S. Muttigi, Byoung Ju Kim, Hemant Kumar, Sunghyun Park, Un Yong Choi, Inbo Han, Hansoo Park and Soo-Hong Lee

    Citation: Stem Cell Research & Therapy 2020 11:363

    Content type: Research

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  8. Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis (PD). Combination therapies are emerging as a promising treatment for tissue damage. Here, we investigated the therapeutic potenti...

    Authors: Yanhong Guo, Liuwei Wang, Rong Gou, Yulin Wang, Xiujie Shi, Xinxin Pang and Lin Tang

    Citation: Stem Cell Research & Therapy 2020 11:362

    Content type: Research

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  9. COVID-19 is a highly infectious respiratory disease. No therapeutics have yet been proven effective for treating severe COVID-19.

    Authors: Lei Shu, Changming Niu, Ruyou Li, Tingrong Huang, Yan Wang, Mao Huang, Ningfei Ji, You Zheng, Xiaolin Chen, Lei Shi, Mingjing Wu, Kaili Deng, Jing Wei, Xueli Wang, Yang Cao, Jiaxin Yan…

    Citation: Stem Cell Research & Therapy 2020 11:361

    Content type: Research

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  10. The development of new treatment strategies to improve peripheral nerve repair after injury, especially those that accelerate axonal nerve regeneration, is very important. The aim of this study is to elucidate...

    Authors: Jiuhong Zhao, Yali Ding, Rui He, Kui Huang, Lu Liu, Chaona Jiang, Zhuozhou Liu, Yuanlan Wang, Xiaokai Yan, Fuyang Cao, Xueying Huang, Yanan Peng, Rui Ren, Yuebin He, Tianwei Cui, Quanpeng Zhang…

    Citation: Stem Cell Research & Therapy 2020 11:360

    Content type: Research

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  11. Mesenchymal stem cells (MSCs) have been widely used for stem cell therapy, and serial passage of stem cells is often required to obtain sufficient cell numbers for practical applications in regenerative medici...

    Authors: Da Hyeon Choi, Se-Young Oh, Ju Kwang Choi, Kyeong Eun Lee, Ju Yeon Lee, Yoon Jeong Park, Inho Jo and Yoon Shin Park

    Citation: Stem Cell Research & Therapy 2020 11:359

    Content type: Research

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  12. Although cord blood (CB) offers promise for treatment of patients with high-risk hematological malignancies and immune disorders, the limited numbers of hematopoietic stem cell (HSC)/progenitor cell in a CB un...

    Authors: Huilin Li, Haiyun Pei, Sihan Wang, Bowen Zhang, Zeng Fan, Yiming Liu, Xiaoyan Xie, Zhou Yang, Lei Xu, Yali Jia, Yun Bai, Yi Han, Lin Chen, Lijuan He, Xue Nan, Wen Yue…

    Citation: Stem Cell Research & Therapy 2020 11:358

    Content type: Research

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  13. Mesenchymal stromal cells (MSCs) are rapidly advancing as commercial therapeutics. However, there are still no adequate tools to validate the identity of MSCs and support standardization of MSC-based products....

    Authors: Danielle M. Wiese and Lorena R. Braid

    Citation: Stem Cell Research & Therapy 2020 11:357

    Content type: Short report

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  14. Extensive passage of adipose-derived stem cells (ASCs) in vitro leads to loss of function. Endothelial colony-forming cells (ECFCs) can be isolated from adult peripheral blood. A 3D co-culture system may rescu...

    Authors: Wansheng Hu, Shengqian Zhu, Mimi Lalrimawii Fanai, Jing Wang, Junrong Cai and Jingwei Feng

    Citation: Stem Cell Research & Therapy 2020 11:355

    Content type: Research

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  15. Deep venous thrombosis (DVT) constitutes a major global disease burden. Endothelial progenitor cells (EPCs) have been described in association with recanalization of venous thrombus. Furthermore, emerging evid...

    Authors: Xiaolong Du, Nan Hu, Huiying Yu, Lei Hong, Feng Ran, Dian Huang, Min Zhou, Chenglong Li and Xiaoqiang Li

    Citation: Stem Cell Research & Therapy 2020 11:354

    Content type: Research

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  16. The aim of the study was to investigate annual structural and functional results, and their correlation with inheritance pattern of retinitis pigmentosa (RP) patients who were treated with Wharton’s jelly-deri...

    Authors: Emin Özmert and Umut Arslan

    Citation: Stem Cell Research & Therapy 2020 11:353

    Content type: Research

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  17. The renal endothelium is a prime target for ischemia-reperfusion injury (IRI) during donation and transplantation procedures. Mesenchymal stromal cells (MSC) have been shown to ameliorate kidney function after...

    Authors: Jesus M. Sierra-Parraga, Ana Merino, Marco Eijken, Henri Leuvenink, Rutger Ploeg, Bjarne K. Møller, Bente Jespersen, Carla C. Baan and Martin J. Hoogduijn

    Citation: Stem Cell Research & Therapy 2020 11:352

    Content type: Research

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  18. Mesenchymal stem cell (MSC)-derived exosomes emerge as promising candidates for treating delayed wound healing in diabetes due to the promotion of angiogenesis. Preconditioned MSC with chemical or biological f...

    Authors: Muyu Yu, Wei Liu, Junxian Li, Junxi Lu, Huijuan Lu, Weiping Jia and Fang Liu

    Citation: Stem Cell Research & Therapy 2020 11:350

    Content type: Research

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  19. The biological role of miR-203 and the underlying mechanisms on the proliferation of epidermal stem cells (ESCs) have not yet been reported during the progression of chronic wound healing in diabetes mellitus....

    Authors: Jian Liu, Bin Shu, Ziheng Zhou, Yingbin Xu, Yiling Liu, Peng Wang, Kun Xiong and Julin Xie

    Citation: Stem Cell Research & Therapy 2020 11:348

    Content type: Research

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  20. Significant developments in stem cell therapy for Parkinson’s disease (PD) have already been achieved; however, methods for reliable assessment of dopamine neuron maturation in vivo are lacking. Establishing t...

    Authors: Julian L. Goggi, Lifeng Qiu, Mei Chih Liao, Shivashankar Khanapur, Lingfan Jiang, Ramasamy Boominathan, Siddesh V. Hartimath, Peter Cheng, Fui Fong Yong, Vanessa Soh, Xiaozhou Deng, Youshan Melissa Lin, Anna Haslop, Peng Wen Tan, Xiaoxia Zeng, Jolene W. L. Lee…

    Citation: Stem Cell Research & Therapy 2020 11:347

    Content type: Research

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  21. Research into the pathogenesis of endometriosis (EMs) would substantially promote its effective treatment and early diagnosis. However, the aetiology of EMs is poorly understood and controversial despite the p...

    Authors: Yanli Liu, Shengying Liang, Fen Yang, Yuliang Sun, Lidan Niu, Yakun Ren, Hongmei Wang, Yanan He, Jiang Du, Jun Yang and Juntang Lin

    Citation: Stem Cell Research & Therapy 2020 11:346

    Content type: Research

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  22. Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic fibroblast-like cells that can differentiate into cells of multiple lineages, such as chondrocytes, osteoblasts, adipocytes, myo...

    Authors: Xiaomo Wu, Ju Jiang, Zhongkai Gu, Jinyan Zhang, Yang Chen and Xiaolong Liu

    Citation: Stem Cell Research & Therapy 2020 11:345

    Content type: Review

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  23. Full-thickness wounds severely affect patients’ life quality and become challenging problems for clinicians. Stem cells have great prospects in the treatment of wounds. Our previous study confirmed that autolo...

    Authors: Shaobin Huang, Zhicheng Hu, Peng Wang, Yi Zhang, Xiaoling Cao, Yunxian Dong, Pu Cheng, Hailin Xu, Wenkai Zhu, Bing Tang and Jiayuan Zhu

    Citation: Stem Cell Research & Therapy 2020 11:344

    Content type: Research

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  24. Inadequate vascularization is a challenge in bone tissue engineering because internal cells are prone to necrosis due to a lack of nutrient supply. Rat bone marrow-derived mesenchymal stem cells (rBMSCs) and h...

    Authors: Miaomiao Chai, Ce Gu, Qihua Shen, Jiaxing Liu, Yi Zhou, Ziyang Jin, Wanli Xiong, Yan Zhou and Wensong Tan

    Citation: Stem Cell Research & Therapy 2020 11:343

    Content type: Research

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  25. Differentiation of mouse trophoblast stem cells (TSCs) to trophoblast giant cells (TGCs) has been widely used as a model system to study placental development and function. While several differentially express...

    Authors: Rahim Ullah, Ambreen Naz, Hafiza Sara Akram, Zakir Ullah, Muhammad Tariq, Aziz Mithani and Amir Faisal

    Citation: Stem Cell Research & Therapy 2020 11:342

    Content type: Research

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  26. The skeletal muscle regeneration relays on the satellite cells which are stem cells located between basal lamina and plasmalemma of muscle fiber. In the injured muscles, the satellite cells become activated, s...

    Authors: Bartosz Mierzejewski, Iwona Grabowska, Daniel Jackowski, Aliksandra Irhashava, Zuzanna Michalska, Władysława Stremińska, Katarzyna Jańczyk-Ilach, Maria Anna Ciemerych and Edyta Brzoska

    Citation: Stem Cell Research & Therapy 2020 11:341

    Content type: Research

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  27. In the clinical study by Le Thi Bich et al., allogeneic expanded umbilical cord-derived mesenchymal stem cells (UC-MSCs) were intravenously infused to treat patients with chronic obstructive pulmonary disease ...

    Authors: Talita Stessuk and João Tadeu Ribeiro-Paes

    Citation: Stem Cell Research & Therapy 2020 11:340

    Content type: Commentary

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    The original article was published in Stem Cell Research & Therapy 2020 11:60

  28. It has been reported that the high-dosage administration of domestically approved pharmaceutical drugs, especially granulocyte colony-stimulating factor (G-CSF) and romiplostim (RP), is a rapid and appropriate...

    Authors: Masaru Yamaguchi, Marino Suzuki, Moeri Funaba, Akane Chiba and Ikuo Kashiwakura

    Citation: Stem Cell Research & Therapy 2020 11:339

    Content type: Research

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  29. The repair of critical-sized bone defect represents a challenging problem in bone tissue engineering. To address the most important problem in bone defect repair, namely insufficient blood supply, this study a...

    Authors: Yuanjia He, Shuang Lin, Qiang Ao and Xiaoning He

    Citation: Stem Cell Research & Therapy 2020 11:338

    Content type: Research

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  30. Selected placental mesenchymal stromal cells isolated from the fetal mesenchymal placental tissues (f-hPSCs) were tested as cell therapy of lethal acute radiation syndrome (ARS) with bone marrow regeneration a...

    Authors: Evgenia Volinsky, Astar Lazmi-Hailu, Nerel Cohen, Boaz Adani, Mohammad Faroja, Myriam Grunewald and Raphael Gorodetsky

    Citation: Stem Cell Research & Therapy 2020 11:337

    Content type: Research

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  31. Diabetic nephropathy (DN) is one of the most serious complications of diabetes and the leading cause of end-stage chronic kidney disease. Currently, there are no effective drugs for treating DN. Therefore, nov...

    Authors: E Xiang, Bing Han, Quan Zhang, Wei Rao, Zhangfan Wang, Cheng Chang, Yaqi Zhang, Chengshu Tu, Changyong Li and Dongcheng Wu

    Citation: Stem Cell Research & Therapy 2020 11:336

    Content type: Research

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  32. Mesenchymal stem cells, including those derived from human adipose tissue (hASCs), are currently being widely investigated for cell therapy. However, when transplanted at the site of injury, the survival and e...

    Authors: Patricia Garrido-Pascual, Ana Alonso-Varona, Begoña Castro, María Burón and Teodoro Palomares

    Citation: Stem Cell Research & Therapy 2020 11:335

    Content type: Research

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  33. Stem cells, including induced pluripotent stem cells (iPSCs), have tremendous potential in health care, though with several significant limitations. Each of the limitations, including immunogenicity, may block...

    Authors: Xiaokai Wang, Meng Lu, Xiaoyu Tian, Yansong Ren, Yijun Li, Meng Xiang and Sifeng Chen

    Citation: Stem Cell Research & Therapy 2020 11:334

    Content type: Research

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  34. Pulpitis is a common dental disease characterized by sustained inflammation and impaired pulp self-repair. Mesenchymal stem cell-based minimally invasive vital pulp therapy (MSC-miVPT) is a potential treatment...

    Authors: Hong Hong, Xiaochuan Chen, Kun Li, Nan Wang, Mengjie Li, Bo Yang, Xiaoqi Yu and Xi Wei

    Citation: Stem Cell Research & Therapy 2020 11:333

    Content type: Research

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  35. Cell therapy using hepatocytes derived from stem cells has been regarded as a promising alternate to liver transplantation. However, the heterogeneity of these hepatocytes makes them unsuitable for therapeutic...

    Authors: Ja Sung Choi, In Sil Jeong, Young-Jin Park and Sung-Whan Kim

    Citation: Stem Cell Research & Therapy 2020 11:332

    Content type: Research

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  36. Mesenchymal stem cells (MSCs) have a limited self-renewal ability, impaired multi-differentiation potential, and undetermined cell senescence during in vitro series expansion. To address this concern, we inves...

    Authors: Zeyuan Cao, Yunyi Xie, Le Yu, Yi Li and Yan Wang

    Citation: Stem Cell Research & Therapy 2020 11:329

    Content type: Research

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  37. Cell-based tissue engineering represents a promising management for meniscus repair and regeneration. The present study aimed to investigate whether the injection of parathyroid hormone (PTH) (1-34) could prom...

    Authors: Wen Zhao, Tong Zou, Hao Cui, Yangou Lv, Dengke Gao, Chenmei Ruan, Xia Zhang and Yihua Zhang

    Citation: Stem Cell Research & Therapy 2020 11:328

    Content type: Research

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  38. Despite the potential, bone marrow-derived mesenchymal stem cells (BMSCs) show limitations for beta (ß)-cell replacement therapy due to inefficient methods to deliver BMSCs into pancreatic lineage. In this stu...

    Authors: Nidheesh Dadheech, Abhay Srivastava, Mitul Vakani, Paresh Shrimali, Ramesh Bhonde and Sarita Gupta

    Citation: Stem Cell Research & Therapy 2020 11:327

    Content type: Research

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  39. Periodontal ligament stem cells (PDLSCs) have many applications in the field of cytotherapy, tissue engineering, and regenerative medicine. However, the effect of age on the biological and immunological charac...

    Authors: Xiaoyu Li, Bowen Zhang, Hong Wang, Xiaolu Zhao, Zijie Zhang, Gang Ding and Fulan Wei

    Citation: Stem Cell Research & Therapy 2020 11:326

    Content type: Research

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  40. Mesenchymal stem cells (MSCs) can regulate innate and adaptive immune systems through interacting with immune cells directly and secreting multiple soluble factors. Due to their immunosuppressive properties, M...

    Authors: Jingjing Qi, Xiaojun Tang, Wenchao Li, Weiwei Chen, Genhong Yao and Lingyun Sun

    Citation: Stem Cell Research & Therapy 2020 11:325

    Content type: Research

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  41. Treating patients with end-stage diffuse coronary artery disease (EnD-CAD) unsuitable for coronary intervention remains a clinical challenge. They usually express refractory angina and have a high risk of mort...

    Authors: Pei-Hsun Sung, Hsin-Ju Chiang, Yi-Chen Li, John Y. Chiang, Chi-Hsiang Chu, Pei-Lin Shao, Fan-Yen Lee, Mel S. Lee and Hon-Kan Yip

    Citation: Stem Cell Research & Therapy 2020 11:324

    Content type: Research

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  42. Extracellular vesicles (EVs) from human mesenchymal stem cells (hMSCs) are known to be mediators of intercellular communication and have been suggested as possible therapeutic agents in many diseases. Their po...

    Authors: Daphne Hingert, Karin Ekström, Jonathan Aldridge, Rosella Crescitelli and Helena Brisby

    Citation: Stem Cell Research & Therapy 2020 11:323

    Content type: Research

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  43. Burns remain a serious public health problem with high morbidity and mortality rates worldwide. Although there are various treatment options available, there is no consensus on the best treatment for severe bu...

    Authors: Yuan Li, Wei-dong Xia, Leanne Van der Merwe, Wen-tong Dai and Cai Lin

    Citation: Stem Cell Research & Therapy 2020 11:322

    Content type: Review

    Published on:

  44. Bone marrow stromal cells (BMSC) have promise in cartilage tissue engineering, but for their potential to be fully realised, the propensity to undergo hypertrophy must be mitigated. The literature contains div...

    Authors: Ena Music, Kathryn Futrega, James S. Palmer, Mackenzie Kinney, Bill Lott, Travis J. Klein and Michael R. Doran

    Citation: Stem Cell Research & Therapy 2020 11:321

    Content type: Research

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  45. There are multiple promising treatment strategies for central nervous system trauma and disease. However, to develop clinically potent and safe treatments, models of human-specific conditions are needed to com...

    Authors: Chenhong Lin, Cinzia Calzarossa, Teresa Fernandez-Zafra, Jia Liu, Xiaofei Li, Åsa Ekblad-Nordberg, Erika Vazquez-Juarez, Simone Codeluppi, Lena Holmberg, Maria Lindskog, Per Uhlén and Elisabet Åkesson

    Citation: Stem Cell Research & Therapy 2020 11:320

    Content type: Research

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    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:369

  46. Gestational diabetes (GDM) is a common complication of pregnancy. The impact of pregnancy complications on placental function suggests that extraembryonic stem cells in the placenta may also be affected during...

    Authors: Liyun Chen, Chung-Teng Wang, Nicholas R. Forsyth and Pensee Wu

    Citation: Stem Cell Research & Therapy 2020 11:319

    Content type: Research

    Published on:

  47. MicroRNAs (miRNAs) play a role in regulating osteogenic differentiation (OD) of mesenchymal stem cells by inhibiting mRNAs translation under cyclic strain. miR-503-3p was downregulated in OD of human adipose-d...

    Authors: Yadong Luo, Xu Ding, Huan Ji, Meng Li, Haiyang Song, Sheng Li, Chenxing Wang, Heming Wu and Hongming Du

    Citation: Stem Cell Research & Therapy 2020 11:318

    Content type: Research

    Published on:

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