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  1. Content type: Research

    Osteochondral injuries represent a significant clinical problem requiring novel cell-based therapies to restore function of the damaged joint with the use of mesenchymal stromal cells (MSCs) leading research e...

    Authors: Hareklea Markides, Karin J. Newell, Heike Rudorf, Lia Blokpoel Ferreras, James E. Dixon, Robert H. Morris, Martin Graves, Joshua Kaggie, Frances Henson and Alicia J. El Haj

    Citation: Stem Cell Research & Therapy 2019 10:25

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  2. Content type: Research

    Acute liver failure (ALF) is a serious threat to the life of people all over the world. Finding an effective way to manage ALF is important. Human liver stem cells (HLSCs) are early undifferentiated cells that...

    Authors: Yanzhen Bi, Jiannan Li, Yonghong Yang, Quanyi Wang, Quanquan Wang, Xiaobei Zhang, Guanjun Dong, Yibo Wang, Zhongping Duan, Zhenfeng Shu, Tongjun Liu, Yu Chen, Kai Zhang and Feng Hong

    Citation: Stem Cell Research & Therapy 2019 10:22

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  3. Content type: Research

    Until now, there is no effective anti-fibrotic therapy available for liver cirrhosis. Stem cell therapies have been studied for the treatment of hepatic fibrosis. However, the use of embryonic stem cells or in...

    Authors: Suhyun Park, Seon In Hwang, Jonghun Kim, Seoyeon Hwang, Sohee Kang, Sera Yang, Jonghwa Kim, Wonseok Kang, Kyun-Hwan Kim, Dong Wook Han and Yong-Han Paik

    Citation: Stem Cell Research & Therapy 2019 10:21

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  4. Content type: Research

    Mesenchymal stem/stromal cells (MSCs) have been widely used to treat various inflammatory diseases. The immunomodulatory capabilities of MSCs are usually licensed by inflammatory cytokines and may vary dependi...

    Authors: Xiaolei Li, Bingxue Shang, Ya-nan Li, Yufang Shi and Changshun Shao

    Citation: Stem Cell Research & Therapy 2019 10:18

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  5. Content type: Research

    Liver fibrosis is a key phase that will progress to further injuries such as liver cirrhosis or carcinoma. This study aimed to investigate whether transplantation of bone marrow mesenchymal stromal cells (BM-M...

    Authors: Xiao-Yu Luo, Xiang-Jun Meng, Da-Chun Cao, Wei Wang, Kun Zhou, Lei Li, Mei Guo and Ping Wang

    Citation: Stem Cell Research & Therapy 2019 10:16

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  6. Content type: Research

    Distraction osteogenesis (DO) is an effective but lengthy procedure to fully induce bone regeneration in large bone defects. Accumulating evidence supports the role of exosomes secreted by endothelial progenit...

    Authors: Yachao Jia, Yu Zhu, Shuo Qiu, Jia Xu and Yimin Chai

    Citation: Stem Cell Research & Therapy 2019 10:12

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  7. Content type: Research

    Human mesenchymal stem cells are a strong candidate for cell therapies owing to their regenerative potential, paracrine regulatory effects, and immunomodulatory activity. Yet, their scarcity, limited expansion...

    Authors: Madison McGrath, Edmund Tam, Martina Sladkova, Athbah AlManaie, Matthew Zimmer and Giuseppe Maria de Peppo

    Citation: Stem Cell Research & Therapy 2019 10:11

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  8. Content type: Research

    Although mesenchymal stem/stromal cell (MSC) chondrogenic differentiation has been thoroughly investigated, the rudiments for enhancing chondrogenesis have remained largely dependent on external cues. Focus to...

    Authors: Melika Sarem, Oliver Otto, Simon Tanaka and V. Prasad Shastri

    Citation: Stem Cell Research & Therapy 2019 10:10

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  9. Content type: Research

    Mouse somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. It has been reported that Sirtuin 6...

    Authors: Peng Xu, Ting-ting Wang, Xiu-zhen Liu, Nan-Yu Wang, Li-hong Sun, Zhu-qin Zhang, Hou-zao Chen, Xiang Lv, Yue Huang and De-Pei Liu

    Citation: Stem Cell Research & Therapy 2019 10:9

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  10. Content type: Research

    The role of brown fat in non-shivering thermogenesis and the discovery of brown fat depots in adult humans has made it the subject of intense research interest. A renewable source of brown adipocyte (BA) proge...

    Authors: Michael D. West, Ching-Fang Chang, Dana Larocca, Jie Li, Jianjie Jiang, Pamela Sim, Ivan Labat, Karen B. Chapman, Kari E. Wong, James Nicoll, Michael J. Van Kanegan, Aubrey D. N. J. de Grey, Igor O. Nasonkin, Andreas Stahl and Hal Sternberg

    Citation: Stem Cell Research & Therapy 2019 10:7

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  11. Content type: Correction

    The original article [1] contained errors in the presentation of Figure 7.

    Authors: Lian Ru Gao, Ning Kun Zhang, Yan Zhang, Yu Chen, Li Wang, Ying Zhu and Hai Hong Tang

    Citation: Stem Cell Research & Therapy 2019 10:6

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    The original article was published in Stem Cell Research & Therapy 2018 9:339

  12. Content type: Research

    The etiology and pathology osteonecrosis of the femoral head (ONFH) are not completely clarified. As a cytokine participating in systemic inflammation, tumor necrosis factor alpha (TNFα) has been shown to be i...

    Authors: Bin Fang, Ding Wang, Jiaqian Zheng, Qiushi Wei, Dongxiang Zhan, Yamei Liu, Xuesong Yang, Haibin Wang, Gang Li, Wei He and Liangliang Xu

    Citation: Stem Cell Research & Therapy 2019 10:5

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  13. Content type: Research

    To explore the effect of mesenchymal stem cells isolated from menstrual blood (MB-MSCs) on epirubicin-induced damage to human ovarian granulosa cells (GCs) and its potential mechanisms.

    Authors: Zhongrui Yan, Fengyi Guo, Qing Yuan, Yu Shao, Yedan Zhang, Huiyan Wang, Shaohua Hao and Xue Du

    Citation: Stem Cell Research & Therapy 2019 10:4

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  14. Content type: Research

    Hertwig’s epithelial root sheath (HERS) is important in guiding tooth root formation by differentiating into cementoblasts through epithelial–mesenchymal transition (EMT) and inducing odontoblastic differentia...

    Authors: Xuebing Li, Sicheng Zhang, Zirui Zhang, Weihua Guo, Guoqing Chen and Weidong Tian

    Citation: Stem Cell Research & Therapy 2019 10:3

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  15. Content type: Research

    Tendon stem/progenitor cells (TSPC) exhibit a low proliferative response to heal tendon injury, leading to limited regeneration outcomes. Exogenous growth factors that activate TSPC proliferation have emerged ...

    Authors: Tsung-Chuan Ho, Shawn H. Tsai, Shu-I Yeh, Show-Li Chen, Kwang-Yi Tung, Hsin-Yu Chien, Yung-Chang Lu, Chang-Hung Huang and Yeou-Ping Tsao

    Citation: Stem Cell Research & Therapy 2019 10:2

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  16. Content type: Research

    Heart failure has become a global health problem with increasing incidences worldwide. Traditional pharmacological treatments can delay but cannot reverse the underlying disease processes. The clinical applica...

    Authors: Fei Zhang, Yuan Xie and Yuhao Bian

    Citation: Stem Cell Research & Therapy 2018 9:358

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  17. Content type: Research

    Methotrexate (MTX) is widely used for the treatment of rheumatoid arthritis (RA). The drug is cost-effective, but sometimes causes hepatotoxicity, requiring a physician’s attention. In this study, we simulated...

    Authors: Juryun Kim, Yena Kim, Jinhyeok Choi, Hyerin Jung, Kijun Lee, Jaewoo Kang, Narae Park, Yeri Alice Rim, Yoojun Nam and Ji Hyeon Ju

    Citation: Stem Cell Research & Therapy 2018 9:357

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  18. Content type: Research

    Bone marrow mesenchymal stem cells (BMSCs) can provide an additional source of therapeutic stem cells for regeneration of liver cells during acute liver injury (ALI). However, the insufficient hepatic homing b...

    Authors: Ting Sun, Feng Gao, Xin Li, Yingyu Cai, Min Bai, Fan Li and Lianfang Du

    Citation: Stem Cell Research & Therapy 2018 9:356

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  19. Content type: Review

    Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) are considered attractive sources of pancreatic β cells and islet organoids. Recently, several reports presented that hESC/iPSC-deri...

    Authors: Hussain Md. Shahjalal, Ahmed Abdal Dayem, Kyung Min Lim, Tak-il Jeon and Ssang-Goo Cho

    Citation: Stem Cell Research & Therapy 2018 9:355

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  20. Content type: Retraction Note

    This article [1] has been retracted by the authors because, contrary to the statement in the article, ethical approval was not obtained to conduct this study.

    Authors: Ihn Han, Miyong Yun, Eun-Ok Kim, Bonglee Kim, Min-Hyung Jung and Sung-Hoon Kim

    Citation: Stem Cell Research & Therapy 2018 9:354

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    The original article was published in Stem Cell Research & Therapy 2014 5:54

  21. Content type: Short report

    A 27-year-old male with HIV-associated naïve and high-risk Burkitt’s lymphoma sequentially received short-term, high-dose non-myeloablative chemotherapy and autologous CD34-positive stem cell transfusion in th...

    Authors: Haiyan Min, Jianwei Yang, Sanbin Wang, Pengfei Tao, Yuqin Song, Xiaopei Wang, Huiqin Li, Xinping Yang, Xingqi Dong, Fu-Sheng Wang, Ming Shi, Xicheng Wang and Ruonan Xu

    Citation: Stem Cell Research & Therapy 2018 9:353

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  22. Content type: Research

    Adipose tissue is an excellent source for isolation of stem cells for treating various clinical conditions including injuries to the neuromuscular system. Many previous studies have focused on differentiating ...

    Authors: R. El-Habta, M. Sloniecka, P. J. Kingham and L. J. Backman

    Citation: Stem Cell Research & Therapy 2018 9:352

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  23. Content type: Research

    Human bone marrow-derived mesenchymal stem/stromal cells (hBM MSCs) have multiple functions, critical for skeletal formation and function. Their functional heterogeneity, however, represents a major challenge ...

    Authors: Alison T. Merryweather-Clarke, David Cook, Barbara Joo Lara, Peng Hua, Emmanouela Repapi, Neil Ashley, Shiang Y. Lim and Suzanne M. Watt

    Citation: Stem Cell Research & Therapy 2018 9:351

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  24. Content type: Research

    Ischemic vascular diseases are the major cause of death worldwide. In recent years, endothelial cell (EC)-based approaches to vascular regeneration are increasingly viable strategies for treating ischemic dise...

    Authors: Fuyi Cheng, Yujing Zhang, Yuan Wang, Qingyuan Jiang, Cheng jian Zhao, Jie Deng, Xiaolei Chen, Yunqi Yao, Zhemin Xia, Lin Cheng, Lei Dai, Gang Shi, Yang Yang, Shuang Zhang, Dechao Yu, Yuquan Wei…

    Citation: Stem Cell Research & Therapy 2018 9:350

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  25. Content type: Review

    The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation by cell reprogramming and the emerging view that ag...

    Authors: Rodolfo G. Goya, Marianne Lehmann, Priscila Chiavellini, Martina Canatelli-Mallat, Claudia B. Hereñú and Oscar A. Brown

    Citation: Stem Cell Research & Therapy 2018 9:349

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  26. Content type: Research

    This study was aimed to investigate the role and specific molecular mechanism of HIF1A-AS2/miR-665/IL6 axis in regulating osteogenic differentiation of adipose-derived stem cells (ASCs) via the PI3K/Akt signal...

    Authors: Ruoyu Wu, Jihao Ruan, Yongjin Sun, Mengyu Liu, Zhuang Sha, Cunyi Fan and Qingkai Wu

    Citation: Stem Cell Research & Therapy 2018 9:348

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  27. Content type: Research

    Millions of people are affected with retinal diseases that eventually cause blindness, and retinal progenitor cell (RPC) transplantation is a promising therapeutic avenue. However, RPC expansion and the underl...

    Authors: Caixia Jin, Qingjian Ou, Zongyi Li, Juan Wang, Jieping Zhang, Haibin Tian, Jing-Ying Xu, Furong Gao, Lixia Lu and Guo-Tong Xu

    Citation: Stem Cell Research & Therapy 2018 9:346

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  28. Content type: Research

    Basic fibroblast growth factor (bFGF) regulates maintenance of stemness and modulation of osteo/odontogenic differentiation and mineralization in stem cells from human exfoliated deciduous teeth (SHEDs). Miner...

    Authors: Nunthawan Nowwarote, Waleerat Sukarawan, Prasit Pavasant, Brian L. Foster and Thanaphum Osathanon

    Citation: Stem Cell Research & Therapy 2018 9:345

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  29. Content type: Research

    Renal ischemia–reperfusion (I/R) injury is a major cause of acute kidney injury (AKI), which is associated with high morbidity and mortality. AKI is a serious and costly medical condition. Effective therapy fo...

    Authors: Wen-Ching Shen, Yu-Hsiang Chou, Hsiang-Po Huang, Jenn-Feng Sheen, Shih-Chieh Hung and Hsin-Fu Chen

    Citation: Stem Cell Research & Therapy 2018 9:344

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  30. Content type: Research

    Bone marrow-derived mesenchymal stem cells (BMSCs) are gradually getting attention because of its multi-directional differentiation potential, hematopoietic support, and promotion of stem cell implantation. Ho...

    Authors: Lihong Wang, Xianjing Han, Guojing Qu, Le Su, Baoxiang Zhao and Junying Miao

    Citation: Stem Cell Research & Therapy 2018 9:343

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  31. Content type: Research

    Three-dimensional (3D) floating culture clumps of mesenchymal stem cell (MSC)/extracellular matrix (ECM) complexes (C-MSCs) consist of cells and self-produced ECM. Previous studies have demonstrated that C-MSC...

    Authors: Nao Komatsu, Mikihito Kajiya, Souta Motoike, Manabu Takewaki, Susumu Horikoshi, Tomoyuki Iwata, Kazuhisa Ouhara, Katsuhiro Takeda, Shinji Matsuda, Tsuyoshi Fujita and Hidemi Kurihara

    Citation: Stem Cell Research & Therapy 2018 9:342

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  32. Content type: Research

    During differentiation of stem cells, it is recognized that molecular mechanisms of transcription factors manage stem cells towards the intended lineage. In this study, using microarray-based technology, gene ...

    Authors: Se Won Yi, Hye Jin Kim, Hyun Jyung Oh, Heejun Shin, Jung Sun Lee, Ji Sun Park and Keun-Hong Park

    Citation: Stem Cell Research & Therapy 2018 9:341

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  33. Content type: Research

    Despite considerable progress in the development of methods for hematopoietic differentiation, efficient generation of transplantable hematopoietic stem cells (HSCs) and other genuine functional blood cells fr...

    Authors: Mengge Wang, Hongtao Wang, Yuqi Wen, Xiaoyuan Chen, Xin Liu, Jie Gao, Pei Su, Yuanfu Xu, Wen Zhou, Lihong Shi and Jiaxi Zhou

    Citation: Stem Cell Research & Therapy 2018 9:340

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  34. Content type: Research

    Apelin plays a key beneficial role in energy metabolism by increasing glucose uptake and insulin sensitivity; however, apelin has a short half-life because it is rapidly cleared from the circulation limiting i...

    Authors: Lian Ru Gao, Ning Kun Zhang, Yan Zhang, Yu Chen, Li Wang, Ying Zhu and Hai Hong Tang

    Citation: Stem Cell Research & Therapy 2018 9:339

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    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:6

  35. Content type: Research

    The Wnt/β-catenin signaling pathway plays an important role in the development of second heart field (SHF Isl1+) that gives rise to the anterior heart field (AHF) cardiac progenitor cells (CPCs) for the format...

    Authors: Yong Fan, Beatrice Xuan Ho, Jeremy Kah Sheng Pang, Nicole Min Qian Pek, Jin Hui Hor, Shi-Yan Ng and Boon-Seng Soh

    Citation: Stem Cell Research & Therapy 2018 9:338

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  36. Content type: Research

    As the implantation and long-term existence of tumor-specific T cells in host are the prerequisite for adoptive immunotherapy, memory stem T cells (TSCM) with self-renewal and differentiation capacity show the gr...

    Authors: Liping Guan, Xiaoyi Li, Jiali Wei, Zhihui Liang, Jing Yang, Xiufang Weng and Xiongwen Wu

    Citation: Stem Cell Research & Therapy 2018 9:337

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  37. Content type: Review

    Mesenchymal stem cells (MSC) comprise a heterogeneous population of rapidly proliferating cells that can be isolated from adult (e.g., bone marrow, adipose tissue) as well as fetal (e.g., umbilical cord) tissu...

    Authors: Ioannis Christodoulou, Maria Goulielmaki, Marina Devetzi, Mihalis Panagiotidis, Georgios Koliakos and Vassilis Zoumpourlis

    Citation: Stem Cell Research & Therapy 2018 9:336

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  38. Content type: Research

    Silicosis is a common occupational disease, characterized by silicotic nodules and diffuse pulmonary fibrosis. We demonstrated an anti-fibrotic effect of bone marrow mesenchymal stem cells (BMSCs) in silica-in...

    Authors: Xiaoli Li, Guoliang An, Yan Wang, Di Liang, Zhonghui Zhu and Lin Tian

    Citation: Stem Cell Research & Therapy 2018 9:335

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  39. Content type: Research

    Stem cells from apical papilla (SCAP) are a subpopulation of mesenchymal stem cells (MSCs) isolated from the apical papilla of the developing tooth root apex of human teeth. Because of their osteogenic/dentino...

    Authors: Yosuke Tanaka, Soichiro Sonoda, Haruyoshi Yamaza, Sara Murata, Kento Nishida, Shion Hama, Yukari Kyumoto-Nakamura, Norihisa Uehara, Kazuaki Nonaka, Toshio Kukita and Takayoshi Yamaza

    Citation: Stem Cell Research & Therapy 2018 9:334

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  40. Content type: Research

    Cell-based regenerative medicine therapies are now frequently tested in clinical trials. In many conditions, cell therapies are administered systemically, but there is little understanding of their fate, and a...

    Authors: Lauren Scarfe, Arthur Taylor, Jack Sharkey, Rachel Harwood, Michael Barrow, Joan Comenge, Lydia Beeken, Cai Astley, Ilaria Santeramo, Claire Hutchinson, Lorenzo Ressel, Jon Smythe, Eric Austin, Raphael Levy, Matthew J. Rosseinsky, Dave J. Adams…

    Citation: Stem Cell Research & Therapy 2018 9:332

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  41. Content type: Research

    Bone tissue engineering is not widely used in clinical treatment. Two main reasons hide behind this: (1) the seed cells are difficult to obtain and (2) the process of tissue engineering bone construction is to...

    Authors: Dingyu Wu, Zhenxing Wang, Jinbing Wang, Yingnan Geng, Zhanzhao Zhang, Yu Li, Qiannan Li, Zhiwei Zheng, Yilin Cao and Zhi-Yong Zhang

    Citation: Stem Cell Research & Therapy 2018 9:331

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  42. Content type: Research

    Menstrual blood-derived endometrial stem cells (MenSCs) emerge as an ideal source for cell-based treatment in regenerative medicine and immunotherapy. However, the major obstacle is the low survival rate in ti...

    Authors: Jiang Du, Xinxing Zhu, Rui Guo, Zhihao Xu, Fang Fang Cheng, Qing Liu, Fen Yang, Lihong Guan, Yanli Liu and Juntang Lin

    Citation: Stem Cell Research & Therapy 2018 9:330

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  43. Content type: Research

    Mesenchymal stem cells (MSCs) are found in synovial fluid (SF) and can easily be harvested during arthrocentesis or arthroscopy. However, SF-MSC characterization and chondrogenicity in collagen sponges have be...

    Authors: Paul Neybecker, Christel Henrionnet, Elise Pape, Didier Mainard, Laurent Galois, Damien Loeuille, Pierre Gillet and Astrid Pinzano

    Citation: Stem Cell Research & Therapy 2018 9:329

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  44. Content type: Research

    The tissue engineering of urinary bladder advances rapidly reflecting clinical need for a new kind of therapeutic solution for patients requiring urinary bladder replacement. Majority of the bladder augmentati...

    Authors: Marta Pokrywczynska, Arkadiusz Jundzill, Marta Rasmus, Jan Adamowicz, Daria Balcerczyk, Monika Buhl, Karolina Warda, Lukasz Buchholz, Maciej Gagat, Dariusz Grzanka and Tomasz Drewa

    Citation: Stem Cell Research & Therapy 2018 9:328

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  45. Content type: Research

    Lung cancer stem cells have the ability to self-renew and are resistant to conventional chemotherapy. MicroRNAs (miRNAs) regulate and control the expression and function of many target genes; therefore, miRNA ...

    Authors: Xiaoyuan Wang, Qingwei Meng, Wenbo Qiao, Ruishuang Ma, Weiwei Ju, Jing Hu, Hailing Lu, Jianqi Cui, Zhao Jin, Yanbin Zhao and Yan Wang

    Citation: Stem Cell Research & Therapy 2018 9:327

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