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  1. Dental implants are widely used to replace missing teeth, providing patients with unparalleled levels of effectiveness, convenience, and affordability. The biological basis for the clinical success of dental i...

    Authors: Yang Ma, Siyuan Wang, Hui Wang, Xiaoyu Chen, Yi Shuai, Huiming Wang, Yingjie Mao and Fuming He
    Citation: Stem Cell Research & Therapy 2023 14:382
  2. With the continuous improvement of human technology, the medical field has gradually moved from molecular therapy to cellular therapy. As a safe and effective therapeutic tool, cell therapy has successfully cr...

    Authors: Jingxuan Li, Zewen Wu, Li Zhao, Yang Liu, Yazhen Su, Xueyan Gong, Fancheng Liu and Liyun Zhang
    Citation: Stem Cell Research & Therapy 2023 14:381
  3. Heart failure (HF) is a major cause of death worldwide. The most effective treatment for HF is heart transplantation, but its use is limited by the scarcity of donor hearts. Recently, stem cell-based therapy h...

    Authors: Jingbo Zhang, Junjun Li, Xiang Qu, Yuting Liu, Akima Harada, Ying Hua, Noriko Yoshida, Masako Ishida, Akiko Tabata, Lifu Sun, Li Liu and Shigeru Miyagawa
    Citation: Stem Cell Research & Therapy 2023 14:380
  4. There are currently no effective clinical therapies to ameliorate the loss of function that occurs after spinal cord injury. Electrical stimulation of the rat spinal cord through the rat tail has previously be...

    Authors: Nandadevi Patil, Olivia Korenfeld, Rachel N. Scalf, Nicolas Lavoie, Anne Huntemer-Silveira, Guebum Han, Riley Swenson and Ann M. Parr
    Citation: Stem Cell Research & Therapy 2023 14:378
  5. Interstitial lung diseases (ILD) are a group of rare lung diseases with severe outcomes. The COST Innovator Grant aims to establish a first-of-a-kind open-access Biorepository of patient-derived induced plurip...

    Authors: Anja Schweikert, Sarah Kenny, Irene Oglesby, Arlene Glasgow, Chiara de Santi, Ingrid Gensch, Nico Lachmann, Tifenn Desroziers, Camille Fletcher, Deborah Snijders, Nadia Nathan and Killian Hurley
    Citation: Stem Cell Research & Therapy 2023 14:377
  6. A 45,X monosomy (Turner syndrome, TS) is the only chromosome haploinsufficiency compatible with life. Nevertheless, the surviving TS patients still suffer from increased morbidity and mortality, with around on...

    Authors: Yumei Luo, Yapei Chen, Lingxia Ge, Guanqing Zhou, Yaoyong Chen and Detu Zhu
    Citation: Stem Cell Research & Therapy 2023 14:376
  7. Recent studies demonstrated that elevated osmolarity could induce adipocyte dedifferentiation, representing an appealing procedure to generate multipotent stem cells. Here we aim to elucidate the molecular mec...

    Authors: Guopan Liu, Ying Wang, Yilin Pan, Li Tian, Ming Ho Choi, Li Wang, Jin Young Kim, Jian Zhang, Shuk Han Cheng and Liang Zhang
    Citation: Stem Cell Research & Therapy 2023 14:333
  8. The meta-analysis by Wang et al. (Stem Cell Res Ther 14(1):103, 2023) aims to explore whether mesenchymal stem cells are effective for perianal fistulas. The authors indicated that the difference in cell types...

    Authors: Fang Cheng
    Citation: Stem Cell Research & Therapy 2023 14:375

    The original article was published in Stem Cell Research & Therapy 2023 14:103

  9. Human iPSCs' derivation and use in clinical studies are transforming medicine. Yet, there is a high cost and long waiting time associated with autologous iPS-based cellular therapy, and the genetic engineering...

    Authors: Maryam Alowaysi, Robert Lehmann, Mohammad Al-Shehri, Moayad Baadhaim, Hajar Alzahrani, Doaa Aboalola, Asima Zia, Dalal Malibari, Mustafa Daghestani, Khaled Alghamdi, Ali Haneef, Dunia Jawdat, Fahad Hakami, David Gomez-Cabrero, Jesper Tegner and Khaled Alsayegh
    Citation: Stem Cell Research & Therapy 2023 14:374
  10. Three-dimensional (3D) cell culture is widely used in various fields of cell biology. In comparison to conventional two-dimensional (2D) cell culture, 3D cell culture facilitates a more accurate replication of...

    Authors: O. Krasnova, A. Kovaleva, A. Saveleva, K. Kulakova, O. Bystrova, M. Martynova, A. Domnina, J. Sopova and I. Neganova
    Citation: Stem Cell Research & Therapy 2023 14:373
  11. Systemic sclerosis (SSc) and sclerodermatous graft-versus-host disease (Scl-GVHD)—characterized by similar developmental fibrosis, vascular abnormalities, and innate and adaptive immune response, resulting in ...

    Authors: Han Yang, Sousan Cheong, Yunfan He and Feng Lu
    Citation: Stem Cell Research & Therapy 2023 14:372
  12. Autoimmune hepatitis is a chronic inflammatory hepatic disorder with no effective treatment. Mesenchymal stromal cells (MSCs) have emerged as a promising treatment owing to their unique advantages. However, th...

    Authors: Xilong Bai, Tingwei Chen, Yuqi Li, Xiaofan Ge, Caie Qiu, Huili Gou, Sili Wei, Tingting Liu, Wei Yang, Liting Yang, Yingmin Liang, Zhansheng Jia, Liangshan Lv and Tianqing Li
    Citation: Stem Cell Research & Therapy 2023 14:370
  13. Allergic airway inflammation is prevalent worldwide and imposes a considerable burden on both society and affected individuals. This study aimed to investigate the therapeutic advantages of mesenchymal stem ce...

    Authors: Peng-Peng Kuang, Xiao-Qing Liu, Chan-Gu Li, Bi-Xin He, Ying-Chun Xie, Zi-Cong Wu, Cheng-Lin Li, Xiao-Hui Deng and Qing-Ling Fu
    Citation: Stem Cell Research & Therapy 2023 14:369
  14. Limbal stem cells (LSCs) are crucial for the regeneration of the corneal epithelium in patients with limbal stem cell deficiency (LSCD). Thus, LSCs during cultivation in vitro should be in highly homogeneous a...

    Authors: Marija Zekušić, Marina Bujić Mihica, Marija Skoko, Kruno Vukušić, Patrik Risteski, Jelena Martinčić, Iva M. Tolić, Krešo Bendelja, Snježana Ramić, Tamara Dolenec, Ivana Vrgoč Zimić, Dominik Puljić, Ivanka Petric Vicković, Renata Iveković, Ivanka Batarilo, Uršula Prosenc Zmrzljak…
    Citation: Stem Cell Research & Therapy 2023 14:368
  15. Human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) hold great promise for cardiac disease modelling, drug discovery and regenerative medicine. Despite the advancement in various differentiation pr...

    Authors: Lee Chuen Liew, Boon Min Poh, Omer An, Beatrice Xuan Ho, Christina Ying Yan Lim, Jeremy Kah Sheng Pang, Leslie Y. Beh, Henry He Yang and Boon-Seng Soh
    Citation: Stem Cell Research & Therapy 2023 14:367
  16. Induced pluripotent stem cell (iPSC)-derived cell therapies are an interesting new area in the field of regenerative medicine. One of the approaches to decrease the costs of iPSC-derived therapies is the use o...

    Authors: B. Kuebler, B. Alvarez-Palomo, B. Aran, J. Castaño, L. Rodriguez, A. Raya, S. Querol Giner and A. Veiga
    Citation: Stem Cell Research & Therapy 2023 14:366
  17. The term sepsis refers to a complex and heterogeneous syndrome. Although great progress has been made in improving the diagnosis and treatment of this condition, it continues to have a huge impact on morbidity...

    Authors: J. F. Vélez-Pinto, M. Garcia-Arranz, D. García-Bernal, S. García Gómez-Heras, P. Villarejo-Campos, A. M. García-Hernández, L. Vega-Clemente, S. Jiménez-Galanes, H. Guadalajara, J. M. Moraleda and D. García-Olmo
    Citation: Stem Cell Research & Therapy 2023 14:365
  18. Human mesenchymal stem cells (hMSCs) utilize discrete biosynthetic pathways to self-renew and differentiate into specific cell lineages, with undifferentiated hMSCs harbouring reliance on glycolysis and hMSCs ...

    Authors: Nuno G. B. Neto, Meenakshi Suku, David A. Hoey and Michael G. Monaghan
    Citation: Stem Cell Research & Therapy 2023 14:364
  19. Despite a long history of investigation and sustained efforts in clinical testing, the number of market authorisations for mesenchymal stromal cell (MSC) therapies remains limited, with none approved by the Un...

    Authors: Joan C. Fitzgerald, Georgina Shaw, J. Mary Murphy and Frank Barry
    Citation: Stem Cell Research & Therapy 2023 14:363
  20. This 1-year open-label extension study aimed to identify the persistent synergistic effects of allogeneic umbilical cord blood (UCB) cells and erythropoietin (EPO) in children with cerebral palsy (CP) for up t...

    Authors: Mi Ri Suh, Kyunghoon Min, Kye Hee Cho, Jongwook Kim, Ikhyun Lim, Mijin Park, Eun-Min Noh and Min Young Kim
    Citation: Stem Cell Research & Therapy 2023 14:362
  21. The ongoing coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on our societies. Moreover, the disease’s extensive and sustained symptoms are now becoming a nonnegligible medical challenge...

    Authors: Xiao Li, Hengrui Hu, Wanlin Liu, Qiyu Zhang, Yujie Wang, Xingjuan Chen, Yunping Zhu, Zhihong Hu, Manli Wang, Jie Ma and Ling Leng
    Citation: Stem Cell Research & Therapy 2023 14:361
  22. Safety evaluations in preclinical studies are needed to confirm before translating a cell-based product into clinical application. We previously developed a serum-free, xeno-free, and chemically defined media ...

    Authors: Xiaoyun Wu, Zhijie Ma, Yuxiao Yang, Yongxu Mu and Daocheng Wu
    Citation: Stem Cell Research & Therapy 2023 14:360
  23. Hepatic osteodystrophy (HOD) is a metabolically associated bone disease mainly manifested as osteoporosis with the characteristic of bone loss induced by chronic liver disease (CLD). Due to its high incidence ...

    Authors: Senzhe Xia, Xueqian Qin, Jinglin Wang and Haozhen Ren
    Citation: Stem Cell Research & Therapy 2023 14:359
  24. Increasing evidence suggests that multipotent mesenchymal stem/stromal cells (MSCs) are a promising intervention strategy in treating autoimmune inflammatory diseases. It should be stated that systemic immunor...

    Authors: Akram Hoseinzadeh, Mahmoud Mahmoudi, Houshang Rafatpanah, Zahra Rezaieyazdi, Jalil Tavakol Afshari, Sara Hosseini and Seyed-Alireza Esmaeili
    Citation: Stem Cell Research & Therapy 2023 14:358
  25. Cardiac remodeling is the initiating factor for the development of heart failure, which can result from various cardiomyopathies. Cytochrome c oxidase subunit 6A2 (COX6A2) is one of the components of cytochrom...

    Authors: Mengqi Jiang, Yuanxiu Song, Xi Chen, Wenjing Lu, Min Zhu, Mingyu Wei, Feng Lan, Ming Cui and Yun Bai
    Citation: Stem Cell Research & Therapy 2023 14:357
  26. Breast cancer (BC) is one of the diseases with the highest female mortality rates in the world and is closely related to breast cancer stem cells (BCSCs). Conventional breast cancer chemotherapy drugs target n...

    Authors: Xinyu Lin, Ying Wang, Kai Fang, Zijian Guo, Nan Lin and Lihua Li
    Citation: Stem Cell Research & Therapy 2023 14:356
  27. Urine-derived stem cells (UDSCs) can be easily isolated from urine and possess excellent stem cell characteristics, making them a promising source for cell therapeutics. Due to their kidney origin specificity,...

    Authors: Sang-Heon Kim, Sung-Hoon Lee, Jeong-Ah Jin, Hyung-Joon So, Jae-Ung Lee, Min-Jae Ji, Eun-Joong Kwon, Pyo-Sung Han, Hong-Ki Lee and Tae-Wook Kang
    Citation: Stem Cell Research & Therapy 2023 14:355
  28. Ventral midbrain (VM) dopaminergic progenitor cells derived from human pluripotent stem cells have the potential to replace endogenously lost dopamine neurons and are currently in preclinical and clinical deve...

    Authors: Pedro Rifes, Marc Isaksson, Charlotte Rusimbi, Adrián Ramón Santonja, Jenny Nelander, Thomas Laurell and Agnete Kirkeby
    Citation: Stem Cell Research & Therapy 2023 14:354
  29. Ischemia/reperfusion injury is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to ...

    Authors: João Faria, Sandra Calcat-i-Cervera, Renata Skovronova, Bonnie C. Broeksma, Alinda J. Berends, Esther A. Zaal, Benedetta Bussolati, Timothy O’Brien, Silvia M. Mihăilă and Rosalinde Masereeuw
    Citation: Stem Cell Research & Therapy 2023 14:353
  30. Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) sheets have recently attracted attention as an alternative approach to injected cell suspensions for stem cell therapy. However, cell engraftment an...

    Authors: Mitsuyoshi Nakao, Makoto Matsui, Kyungsook Kim, Nobuhiro Nishiyama, David W. Grainger, Teruo Okano, Hideko Kanazawa and Kenichi Nagase
    Citation: Stem Cell Research & Therapy 2023 14:352
  31. Kupffer cells (KCs) originate from yolk-sac progenitors before birth. Throughout adulthood, they self-maintain independently from the input of circulating monocytes (MOs) at a steady state and are replenished ...

    Authors: Xu Fan, Pei Lu, Xiang-Hua Cui, Peng Wu, Wei-Ran Lin, Dong Zhang, Shong-Zong Yuan, Bing Liu, Fang-Yan Chen, Hong You, Han-Dong Wei, Fu-Chu He, Ji-Dong Jia and Ying Jiang
    Citation: Stem Cell Research & Therapy 2023 14:351
  32. The objective of this study was to identify potential biomarkers for predicting response to MSC therapy by pre-MSC treatment plasma proteomic profile in severe COVID-19 in order to optimize treatment choice.

    Authors: Tian-Tian Li, Wei-Qi Yao, Hai-Bo Dong, Ze-Rui Wang, Zi-Ying Zhang, Meng-Qi Yuan, Lei Shi and Fu-Sheng Wang
    Citation: Stem Cell Research & Therapy 2023 14:350
  33. Various methods for ex utero culture systems have been explored. However, limitations remain regarding the in vitro culture platforms used before implanting mouse embryos and the normal development of mouse bl...

    Authors: Junjun Xu, Linye Zhang, Zihui Ye, Binwen Chang, Zheng Tu, Xuguang Du, Xi Wen and Yili Teng
    Citation: Stem Cell Research & Therapy 2023 14:349
  34. Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is a fatal neurodegenerative disease with currently no treatment options. Stem cell therapy for neurodegenerative diseases is eme...

    Authors: Katie Williams, Simote T. Foliaki, Brent Race, Anna Smith, Tina Thomas, Bradley R. Groveman and Cathryn L. Haigh
    Citation: Stem Cell Research & Therapy 2023 14:348
  35. Mesenchymal stromal cells (MSCs) show considerable promise in regenerative medicine with superior anti-fibrotic, immunomodulatory, and angiogenic functions. More recently, discovered with the tumor tropism, MS...

    Authors: Yizuo Song, Hejing Liu, Shuya Pan, Xinli Xiang, Miaomiao Ye and Xueqiong Zhu
    Citation: Stem Cell Research & Therapy 2023 14:347
  36. The CRX-associated autosomal dominant retinopathies suggest a possible pathogenic mechanism of gene haploinsufficiency. However, based on reported human patient cases and studies with mouse models, it is hard to ...

    Authors: Deng Pan, Xiao Zhang, Kangxin Jin and Zi-Bing Jin
    Citation: Stem Cell Research & Therapy 2023 14:346
  37. Genomic sequencing in congenital heart disease (CHD) patients often discovers novel genetic variants, which are classified as variants of uncertain significance (VUS). Functional analysis of each VUS is requir...

    Authors: Vanessa S. Fear, Catherine A. Forbes, Nicole C. Shaw, Kathryn O. Farley, Jessica L. Mantegna, Jasmin P. Htun, Genevieve Syn, Helena Viola, Henrietta Cserne Szappanos, Livia Hool, Michelle Ward, Gareth Baynam and Timo Lassmann
    Citation: Stem Cell Research & Therapy 2023 14:345
  38. Mesenchymal stromal cells (MSCs) have regenerative and immunomodulatory properties, making them suitable for cell therapy. Toll-like receptors (TLRs) in MSCs respond to viral load by secreting immunosuppressiv...

    Authors: Tatiana Tolstova, Ekaterina Dotsenko, Peter Kozhin, Svetlana Novikova, Victor Zgoda, Alexander Rusanov and Nataliya Luzgina
    Citation: Stem Cell Research & Therapy 2023 14:344
  39. The Wnt signaling pathway has been implicated in the pathogenesis of fibrotic disorders and malignancies. Hence, we aimed to assess the potential of the induced pluripotent stem cells (IPS) in modulating the e...

    Authors: Paria Bayati, Marjan Taherian, Mansoureh Soleimani, Hamid Farajifard and Nazanin Mojtabavi
    Citation: Stem Cell Research & Therapy 2023 14:343
  40. Epithelial–mesenchymal transition (EMT) is a cell remodeling process in which epithelial cells undergo a reversible phenotype switch via the loss of adhesion capacity and acquisition of mesenchymal characteris...

    Authors: Raheleh Farahzadi, Behnaz Valipour, Ezzatollah Fathi, Samaneh Pirmoradi, Ommoleila Molavi, Soheila Montazersaheb and Zohreh Sanaat
    Citation: Stem Cell Research & Therapy 2023 14:342
  41. The functional impairment of adipose stem cells (ASCs) during aging limits their clinical transformation. Studies have shown that extrachromosomal circular DNAs (eccDNAs) are associated with tumor progression ...

    Authors: Sen Ren, Du Wu, Xiaoyong Shen, Qian Wu, Chengcheng Li, Hewei Xiong, Zhongwei Xiong, Rui Gong, Zheng Liu, Wei Wang and Jincao Chen
    Citation: Stem Cell Research & Therapy 2023 14:341
  42. Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration and impose a considerable economic burden on patients and society, making efforts to cure blindness imperative. Transg...

    Authors: Yuqin Liang, Xihao Sun, Chunwen Duan, Shibo Tang and Jiansu Chen
    Citation: Stem Cell Research & Therapy 2023 14:340
  43. The secretome of mesenchymal stromal cells isolated from the amniotic membrane (hAMSCs) has been extensively studied for its in vitro immunomodulatory activity as well as for the treatment of several preclinic...

    Authors: Alexandra Muntiu, Andrea Papait, Federica Vincenzoni, Alberto Vitali, Wanda Lattanzi, Pietro Romele, Anna Cargnoni, Antonietta Silini, Ornella Parolini and Claudia Desiderio
    Citation: Stem Cell Research & Therapy 2023 14:339
  44. Contrast-induced nephropathy (CIN) is a major clinical problem associated with acute kidney injury during hospitalization. However, effective treatments for CIN are currently lacking. Mesenchymal stem cells (M...

    Authors: Mitsuki Kadono, Ayumu Nakashima, Naoki Ishiuchi, Kensuke Sasaki, Yoshie Miura, Satoshi Maeda, Asuka Fujita, Ayano Sasaki, Shogo Nagamatsu and Takao Masaki
    Citation: Stem Cell Research & Therapy 2023 14:337
  45. Kidney organoids derived from human pluripotent stem cells (HiPSCs) hold huge applications for drug screening, disease modeling, and cell transplanting therapy. However, these applications are limited since ki...

    Authors: Kexin Peng, Wanqin Xie, Tingting Wang, Yamei Li, Jean de Dieu Habimana, Obed Boadi Amissah, Jufang Huang, Yong Chen, Bin Ni and Zhiyuan Li
    Citation: Stem Cell Research & Therapy 2023 14:336
  46. The metabolic reprogramming of mesenchymal stem/stromal cells (MSC) favoring glycolysis has recently emerged as a new approach to improve their immunotherapeutic abilities. This strategy is associated with gre...

    Authors: Carolina Pradenas, Noymar Luque-Campos, Karina Oyarce, Rafael Contreras-Lopez, Felipe A. Bustamante-Barrientos, Andrés Bustos, Felipe Galvez-Jiron, María Jesús Araya, Catalina Asencio, Raúl Lagos, Yeimi Herrera-Luna, Daouda Abba Moussa, Charlotte Nicole Hill, Eliana Lara-Barba, Claudia Altamirano, Alexander Ortloff…
    Citation: Stem Cell Research & Therapy 2023 14:335
  47. Mesenchymal stem cells (MSCs) are adult stem cells with self-renewal and multi-directional differentiation potential and possess the functions of immunomodulation, regulation of cell growth, and repair of dama...

    Authors: Jingfang Xiao, Xiaoyuan Gong, Zhenlan Fu, Xiongbo Song, Qinghua Ma, Jingya Miao, Ruili Cai, Zexuan Yan, Shuai Wang, Qian Li, Yaokai Chen, Liu Yang, Xiuwu Bian and Yemiao Chen
    Citation: Stem Cell Research & Therapy 2023 14:334

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