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  1. Osteoporosis affects the mandible resulting in bone loss. Though impairments are not life threatening, they affect a person's quality-of-life particularly vulnerable elderly. MicroRNAs (miRNAs) are novel regul...

    Authors: Shaoming Li, Ling Gao, Weidong Zhang, Yanbin Yu, Jingjing Zheng, Xiao Liang, Shanshan Xin, Wenhao Ren and Keqian Zhi
    Citation: Stem Cell Research & Therapy 2022 13:359
  2. Human mesenchymal stromal cells (MSCs) have immunomodulatory, anti-inflammatory, and tolerogenic effects. Long-term in vitro expansion of MSCs to generate clinical grade products results in the accumulation of...

    Authors: Rose Triantafillia Psaroudis, Urvashi Singh, Maximilien Lora, Peter Jeon, Abigail Boursiquot, Ursula Stochaj, David Langlais and Inés Colmegna
    Citation: Stem Cell Research & Therapy 2022 13:358
  3. Adipose tissue inflammation is considered as one of the major mechanisms underlying the pathogenesis of insulin resistance and complications in diabetes. Here, we aimed to study the effects of adipose-derived ...

    Authors: Lee-Wei Chen, Pei-Hsuan Chen, Chia-Hua Tang and Jui-Hung Yen
    Citation: Stem Cell Research & Therapy 2022 13:357
  4. In diabetic kidney disease, high glucose damages specialized cells called podocytes that filter blood in the glomerulus. In vitro culture of podocytes is crucial for modeling of diabetic nephropathy and geneti...

    Authors: Julie Bejoy, Justin M. Farry, Jennifer L. Peek, Mariana C. Cabatu, Felisha M. Williams, Richard C. Welch, Eddie S. Qian and Lauren E. Woodard
    Citation: Stem Cell Research & Therapy 2022 13:355
  5. Mesenchymal stem cells (MSCs) are considered to be a potential therapeutic tool for liver fibrosis. Inhibiting the activation of hepatic stellate cells (HSCs) and protecting hepatocytes are important mechanism...

    Authors: Qing Zhou, Chao Rong, Tengfei Gu, Hongda Li, Lei Wu, Xuemei Zhuansun, Xin Zhao, Zuorun Xiao, Yuting Kuang, Sanrong Xu and Shouli Wang
    Citation: Stem Cell Research & Therapy 2022 13:354
  6. Hemophilia B is a rare inherited genetic bleeding disorder caused by a deficiency or lack of coagulation factor IX, the gene for which (F9) is located on the X chromosome. Hemophilia B is currently incurable and ...

    Authors: Yanchun Ma, Wenwen Sun, Lidong Zhao, Mingze Yao, Changxin Wu, Pengfei Su, Linhua Yang and Gang Wang
    Citation: Stem Cell Research & Therapy 2022 13:353
  7. In our previous research, we found that overexpression of miR-126-3p in human umbilical cord MSCs (hucMSCs) promoted human umbilical vein endothelial cells angiogenic activities through exosome-mediated mechan...

    Authors: Qingxi Qu, Linghong Liu, Yuqian Cui, Hongli Liu, Jingyang Yi, Weidong Bing, Chunxiao Liu, Detian Jiang and Yanwen Bi
    Citation: Stem Cell Research & Therapy 2022 13:352
  8. Stem cell niche maintains stem cell population identity and is essential for the homeostasis of self-renewal and differentiation in Drosophila testes. However, the mechanisms of CySC lineage signals-mediated soma...

    Authors: Zhiran Li, Yunhao Wu, Yangbo Fu, Xia Chen, Xi Zhao, Xiaolong Wu, Yajuan Lu, Hui He, Cong Shen, Bo Zheng, Jun Yu and Fei Sun
    Citation: Stem Cell Research & Therapy 2022 13:351
  9. The purpose of this study was to investigate allogenic immune responses following the transplantation of insulin-producing cells (IPCs) differentiated from human adipose tissue-derived stem cells (hAT-MSCs) in...

    Authors: Mohamed A. Ghoneim, Mahmoud M. Gabr, Ayman F. Refaie, Sawsan M. El-Halawani, Mohga M. Al-issawi, Batoul L. Elbassiouny, Mai A. Abd El Kader, Amani M. Ismail, Mona F. Zidan, Mary S. Karras, Raghda W. Magar, Sherry M. Khater, Sylvia A. Ashamallah, Mahmoud M. Zakaria and Malgorzata Kloc
    Citation: Stem Cell Research & Therapy 2022 13:350
  10. Preclinical studies have suggested that adipose-derived mesenchymal stem cells (ADSCs) transplantation can suppress abdominal aortic inflammation and aneurysm expansion through paracrine factors. Yet, the mech...

    Authors: Jiateng Hu, Yihong Jiang, Xiaoyu Wu, Zhaoyu Wu, Jinbao Qin, Zhen Zhao, Bo Li, Zhijue Xu, Xinwu Lu, Xin Wang and Xiaobing Liu
    Citation: Stem Cell Research & Therapy 2022 13:349
  11. Bone marrow mesenchymal stromal cells (BM-MSCs) have anti-inflammatory and pro-survival properties. Naturally, they do not express human leukocyte antigen class II surface antigens and have immunosuppressive c...

    Authors: Zahra Azizi, Roya Abbaszadeh, Roxana Sahebnasagh, Amir Norouzy, Elahe Motevaseli and Kathrin Maedler
    Citation: Stem Cell Research & Therapy 2022 13:348
  12. Emerging drug-free in vitro activation (IVA) technique enables patients with premature ovarian insufficiency (POI) to restore ovarian function and conceive their own genetic offspring. However, various issues ...

    Authors: Qian Li, Jiahua Zheng, Zhongkang Li, Yanlai Xiao, Mingle Zhang, Wenxin Shi, He Gao, Xianghua Huang and Jingkun Zhang
    Citation: Stem Cell Research & Therapy 2022 13:347
  13. Cryostorage of spermatogonial stem cells (SSCs) is an appropriate procedure for long-term storage of SSCs for fertility preservation. However, it causes damage to cellular structures through overproduction of ...

    Authors: Shokoofeh Kazemzadeh, Shahram Mohammadpour, Soheila Madadi, Azar Babakhani, Maryam Shabani and Maryam Khanehzad
    Citation: Stem Cell Research & Therapy 2022 13:346
  14. Peripheral arterial disease is atherosclerotic occlusive disease of the lower extremity arteries and afflicts hundreds of millions of individuals worldwide. Its most severe manifestation is chronic limb-threat...

    Authors: Laura V. Lozano Navarro, Xueyi Chen, Lady Tatiana Giratá Viviescas, Andrea K. Ardila-Roa, Maria L. Luna-Gonzalez, Claudia L. Sossa and Martha L. Arango-Rodríguez
    Citation: Stem Cell Research & Therapy 2022 13:345
  15. Mesenchymal-based therapy has been utilized as a practical approach in the treatment of renal ischemia/reperfusion (I/R) injury. However, low cell retention and survival in the ischemic site have remained chal...

    Authors: Haniyeh Najafi, Samira Sadat Abolmaali, Reza Heidari, Hadi Valizadeh, Ali Mohammad Tamaddon and Negar Azarpira
    Citation: Stem Cell Research & Therapy 2022 13:344
  16. The imbalance of osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is closely related to steroid-induced avascular necrosis of the femoral head (SANFH). We aimed to investigat...

    Authors: Ping Duan, Hanyu Wang, Xinzeyu Yi, Hao Zhang, Hui Chen and Zhenyu Pan
    Citation: Stem Cell Research & Therapy 2022 13:342
  17. Traumatic brain injury (TBI) leads to cell and tissue impairment, as well as functional deficits. Stem cells promote structural and functional recovery and thus are considered as a promising therapy for variou...

    Authors: Qiaozhen Qin, Ting Wang, Zhenhua Xu, Shuirong Liu, Heyang Zhang, Zhangzhen Du, Jianing Wang, Yadi Wang, Zhenning Wang, Shanshan Yuan, Jiamei Wu, Wenyan He, Changzhen Wang, Xinlong Yan, Yan Wang and Xiaoxia Jiang
    Citation: Stem Cell Research & Therapy 2022 13:341
  18. Nucleus pulposus mesenchymal stem cells (NPMSCs) transplantation is a promising treatment for intervertebral disc degeneration (IVDD). However, the transplanted NPMSCs exhibited weak cell proliferation, high c...

    Authors: Yu-yao Zhang, Zhi-lei Hu, Yu-han Qi, Hai-yin Li, Xian Chang, Xiao-xin Gao, Chen-hao Liu, Yue-yang Li, Jin-hui Lou, Yu Zhai and Chang-qing Li
    Citation: Stem Cell Research & Therapy 2022 13:340
  19. The differentiation of human induced pluripotent stem cells (iPSCs) into oocytes, which involves the transformation from mitosis to meiosis, has been a hotspot of biological research for many years and represe...

    Authors: Sheng Yang, Zhen Liu, Shengda Wu, Lang Zou, Yanpei Cao, Hongjia Xu, Jingfeng Huang, Qingyan Tian, Fanggui Wu, Panpan Li, Shuping Peng and Cijun Shuai
    Citation: Stem Cell Research & Therapy 2022 13:339
  20. Organoids are 3D structures grown from pluripotent stem cells derived from human tissue and serve as in vitro miniature models of human organs. Organoids are expected to revolutionize biomedical research and c...

    Authors: Dide de Jongh, Emma K. Massey and Eline M. Bunnik
    Citation: Stem Cell Research & Therapy 2022 13:337
  21. Diabetic foot ulcer (DFU) is a chronic infectious disease caused by diabetes mellitus (DM). Angiogenesis plays the decisive role in wound healing of DFU. Adipose-derived stem cells (ADSCs) can ameliorate angio...

    Authors: Zun-Hong Liang, Nan-Fang Pan, Shi-Shuai Lin, Zhi-Yang Qiu, Ping Liang, Jun Wang, Zhi Zhang and Yun-Chuan Pan
    Citation: Stem Cell Research & Therapy 2022 13:336
  22. There is increasing evidence that mesenchymal stem cells (MSCs) help shape the tumor microenvironment and promote tumor progression, and ion channels might play a critical role in this process. The objective o...

    Authors: Chunling Xue, Yang Gao, Xuechun Li, Mingjia Zhang, Ying Yang, Qin Han, Zhao Sun, Chunmei Bai and Robert Chunhua Zhao
    Citation: Stem Cell Research & Therapy 2022 13:335
  23. Acne is a chronic facial disease caused by Propionibacterium acnes, which proliferates within sebum-blocked skin follicles and increases inflammatory cytokine production. Several therapeutic drugs and products ha...

    Authors: Xiaoxi Li, Sai Luo, Xinyao Chen, Shasha Li, Lijun Hao and Dan Yang
    Citation: Stem Cell Research & Therapy 2022 13:334
  24. Mesenchymal stromal cells (MSCs) activated with IFN-γ elicit stronger physical effects. Exosomes (Exos) secreted from MSCs show protective effects against myocardial injury. This study aimed to determine wheth...

    Authors: Jian Zhang, Yao Lu, Yangming Mao, Yue Yu, Tianyu Wu, Wei Zhao, Yeqian Zhu, Pengcheng Zhao and Fengxiang Zhang
    Citation: Stem Cell Research & Therapy 2022 13:333
  25. Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have emerged as a powerful tool for disease modeling, though their immature nature currently limits translation into clinical practice. Maturatio...

    Authors: Sofija Vučković, Rafeeh Dinani, Edgar E. Nollet, Diederik W. D. Kuster, Jan Willem Buikema, Riekelt H. Houtkooper, Miranda Nabben, Jolanda van der Velden and Birgit Goversen
    Citation: Stem Cell Research & Therapy 2022 13:332
  26. Due to the large area and deep width of the artificial neovagina after vaginoplasty, it takes a considerable amount of time to achieve complete epithelization of the neovagina. Currently, the clinical therapie...

    Authors: Yiyun Xu, Yu Qiu, Qiuning Lin, Chengsheng Huang, Jie Li, Liqi Chen, Zhuowei Xue, Qingkai Wu and Yang Wang
    Citation: Stem Cell Research & Therapy 2022 13:331
  27. Despite emerging evidence on the therapeutic potential of mesenchymal stem cells (MSCs) for liver fibrosis, the underlying mechanisms remain unclear. At present, MSC-derived exosomes (MSC-EXOs) are widely acce...

    Authors: Siyuan Tian, Xia Zhou, Miao Zhang, Lina Cui, Bo Li, Yansheng Liu, Rui Su, Keshuai Sun, Yinan Hu, Fangfang Yang, Guoyun Xuan, Shuoyi Ma, Xiaohong Zheng, Xinmin Zhou, Changcun Guo, Yulong Shang…
    Citation: Stem Cell Research & Therapy 2022 13:330
  28. The requirement of the Mek1 inhibitor (iMek1) during naïve pluripotency maintenance results from the activation of the Mek1-Erk1/2 (Mek/Erk) signaling pathway upon leukemia inhibitory factor (LIF) stimulation.

    Authors: Seong-Min Kim, Eun-Ji Kwon, Yun-Jeong Kim, Young-Hyun Go, Ji-Young Oh, Seokwoo Park, Jeong Tae Do, Keun-Tae Kim and Hyuk-Jin Cha
    Citation: Stem Cell Research & Therapy 2022 13:329
  29. The mechanism by which mesenchymal stem cell (MSC) transplantation alleviates atherosclerosis in systemic lupus erythematosus (SLE) remains elusive. In this study, we aim to explore the efficacy and mechanism ...

    Authors: Genhong Yao, Jingjing Qi, Xiaojing Li, Xiaojun Tang, Wenchao Li, Weiwei Chen, Nan Xia, Shiying Wang and Lingyun Sun
    Citation: Stem Cell Research & Therapy 2022 13:328
  30. Angiogenesis is required in many physiological conditions, including bone regeneration, wound healing, and tissue regeneration. Mesenchymal stem cells-derived extracellular matrix (MSCs-ECM) could guide intric...

    Authors: Beilei Ma, Tengkai Wang, Juan Li and Qian Wang
    Citation: Stem Cell Research & Therapy 2022 13:327
  31. Bone marrow mesenchymal stem cell (BMSCs) therapy is an important cell transplantation strategy in the regenerative medicine field. However, a severely ischemic microenvironment, such as nutrient depletion and...

    Authors: Yanting Sun, Hao Xu, Bin Tan, Qin Yi, Huiwen Liu, Tangtian Chen, Han Xiang, Rui Wang, Qiumin Xie, Jie Tian and Jing Zhu
    Citation: Stem Cell Research & Therapy 2022 13:326
  32. Flap transplantation is commonly used in reconstructive surgery. A prerequisite for skin flap survival is sufficient blood supply. However, such approaches remain unclear. This study aimed to explore the under...

    Authors: Linlin Guo, Yuxuan Chen, Xiaoling Feng, Di Sun, Jiaming Sun, Shan Mou, Kangcheng Zhao and Ran An
    Citation: Stem Cell Research & Therapy 2022 13:325
  33. The source of SAN is debated among researchers. Many studies have shown that RA and Wnt signaling are involved in heart development. In this study, we investigated the role of retinoic acid (RA) and Wnt signal...

    Authors: Lin Yin, Feng-yuan Wang, Wei Zhang, Xi Wang, Yan-hong Tang, Teng Wang, Yu-ting Chen and Cong-xin Huang
    Citation: Stem Cell Research & Therapy 2022 13:324
  34. In tissue engineering, mesenchymal stem cells (MSCs) are common seed cells because of abundant sources, strong proliferation ability and immunomodulatory function. Numerous researches have demonstrated that MS...

    Authors: Yuan Zhu, Xiao Zhang, Kunkun Yang, Yuzi Shao, Ranli Gu, Xuenan Liu, Hao Liu, Yunsong Liu and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2022 13:323
  35. Osteoarthritis (OA) is a prevalent degenerative joint disease that not only significantly impairs the quality of life of middle-aged and elderly individuals but also imposes a significant financial burden on p...

    Authors: Hao Zhou, Xun Shen, Chen Yan, Wu Xiong, Zemeng Ma, Zhenggang Tan, Jinwen Wang, Yao Li, Jiuxiang Liu, Ao Duan and Feng Liu
    Citation: Stem Cell Research & Therapy 2022 13:322
  36. The novel coronavirus is still mutating, and the pandemic continues. Meanwhile, many COVID-19 survivors have residual postinfection clinical manifestations. Human umbilical cord mesenchymal stem cells (hUC-MSC...

    Authors: Lei Shi, You Zheng, Zhi Cheng, Ningfei Ji, Changming Niu, Yan Wang, Tingrong Huang, Ruyou Li, Mao Huang, Xiaolin Chen, Lei Shu, Mingjing Wu, Kaili Deng, Jing Wei, Xueli Wang, Yang Cao…
    Citation: Stem Cell Research & Therapy 2022 13:321
  37. Premature ovarian insufficiency (POI) is a refractory disease that seriously affects the reproductive health of women and is increasing in incidence and prevalence globally. There is enormous demand to improve...

    Authors: Mengyu Liu, Dan Zhang, Xiaowei Zhou, Jingru Duan, Yanqin Hu, Wenjie Zhang, Qiang Liu, Bufang Xu and Aijun Zhang
    Citation: Stem Cell Research & Therapy 2022 13:320
  38. The implantation of dedifferentiated fat (DFAT) cells has been shown to exert immunosuppressive effects. To develop DFAT cell therapy for antineutrophil cytoplasmic antibody (ANCA) glomerulonephritis, the effe...

    Authors: Kei Utsunomiya, Takashi Maruyama, Satoshi Shimizu, Taro Matsumoto, Morito Endo, Hiroki Kobayashi, Koichiro Kano, Masanori Abe and Noboru Fukuda
    Citation: Stem Cell Research & Therapy 2022 13:319
  39. Notch signaling plays important roles in regulating innate immunity. However, little is known about the role of Notch in mesenchymal stromal/stem cell (MSC)-mediated immunomodulation during liver inflammatory ...

    Authors: Mengxue Yu, Min Zhou, Jiahui Li, Ruobin Zong, Yufei Yan, Liangyi Kong, Qiang Zhu and Changyong Li
    Citation: Stem Cell Research & Therapy 2022 13:318
  40. One of the severe complications occurring because of the patient’s intubation is tracheal stenosis. Its incidence has significantly risen because of the COVID-19 pandemic and tends only to increase. Here, we p...

    Authors: Alexey Fayzullin, Georgiy Vladimirov, Anastasia Kuryanova, Elvira Gafarova, Sergei Tkachev, Nastasia Kosheleva, Elena Istranova, Leonid Istranov, Yuri Efremov, Ivan Novikov, Polina Bikmulina, Kirill Puzakov, Pavel Petrov, Ivan Vyazankin, Andrey Nedorubov, Tatyana Khlebnikova…
    Citation: Stem Cell Research & Therapy 2022 13:317
  41. Pulmonary arterial hypertension (PAH) is associated with oxidative stress and affects the survival and homing of transplanted mesenchymal stem cells (MSCs) as well as cytokine secretion by the MSCs, thereby al...

    Authors: De-Tian Jiang, Lei Tuo, Xiao Bai, Wei-Dong Bing, Qing-Xi Qu, Xin Zhao, Guang-Min Song, Yan-Wen Bi and Wen-Yu Sun
    Citation: Stem Cell Research & Therapy 2022 13:316
  42. Exosomes derived from mesenchymal stem cells (MSCs) have shown to have effective application prospects in the medical field, but exosome yield is very low. The production of exosome mimetic vesicles (EMVs) by ...

    Authors: Zhaoxia Zhang, Tao Mi, Liming Jin, Mujie Li, Chenghao Zhanghuang, Jinkui Wang, Xiaojun Tan, Hongxu Lu, Lianju Shen, Chunlan Long, Guanghui Wei and Dawei He
    Citation: Stem Cell Research & Therapy 2022 13:312
  43. Type 1 diabetes mellitus (T1D) is a chronic disease characterized by an autoimmune destruction of insulin-producing β-pancreatic cells. Although many advances have been achieved in T1D treatment, current therapy ...

    Authors: Isaura Beatriz Borges Silva, Camila Harumi Kimura, Vitor Prado Colantoni and Mari Cleide Sogayar
    Citation: Stem Cell Research & Therapy 2022 13:309
  44. Current treatments for salivary gland (SG) hypofunction are palliative and do not address the underlying cause or progression of the disease. SG-derived stem cells have the potential to treat SG hypofunction, ...

    Authors: Olivia N. Tran, Hanzhou Wang, Shengxian Li, Andrey Malakhov, Yuyang Sun, Parveez A. Abdul Azees, Aaron O. Gonzalez, Brian Cao, Milos Marinkovic, Brij B. Singh, David D. Dean, Chih-Ko Yeh and Xiao-Dong Chen
    Citation: Stem Cell Research & Therapy 2022 13:306
  45. Myelomeningocele (MMC) is a spinal cord congenital defect that leads to paraplegia, sphincter disorders and potential neurocognitive disabilities. Prenatal surgery of MMC provides a significant benefit compare...

    Authors: Yoann Athiel, Justine Nasone, Lousineh Arakelian, Lionel Faivre, Anaïs Dugas, Jean-Marie Jouannic, Jérôme Larghero and Lucie Guilbaud
    Citation: Stem Cell Research & Therapy 2022 13:300
  46. Human urine-derived stem cells (USCs)-derived exosomes (USC-Exo) could improve kidney ischemia/reperfusion injury (IRI), while the underlying mechanisms of this protective effect remain unclear.

    Authors: Zejia Sun, Jiyue Wu, Qing Bi and Wei Wang
    Citation: Stem Cell Research & Therapy 2022 13:297
  47. Ovarian tissue cryopreservation and transplantation are novel therapeutic approaches for fertility preservation. However, follicle loss caused by ischemic and hypoxic damage is one of the issues after frozen-t...

    Authors: Wenjuan Xu, Caiyun Wu, Xiaoqian Zhu, Jingjing Wu, Zhiguo Zhang, Zhaolian Wei, Yunxia Cao, Ping Zhou and Jianye Wang
    Citation: Stem Cell Research & Therapy 2022 13:296
  48. Recent studies have shown that bone marrow stromal cell-derived exosomes (BMSC-Exos) can be used for tissue repair. However, whether the BMSC-Exos can promote tendon-bone healing after anterior cruciate ligame...

    Authors: Zhenyu Li, Qingxian Li, Kai Tong, Jiayong Zhu, Hui Wang, Biao Chen and Liaobin Chen
    Citation: Stem Cell Research & Therapy 2022 13:295
  49. Endometriosis (EMs) is a common benign gynecological disease that affects approximately 10% of females of reproductive age. Endometriosis ectopic lesions could recruit macrophages, which in turn facilitates en...

    Authors: Jiahuan Tan, Tenghan Xu, Yanling Gou, Honglin Wang, Zongwen Liang, Yingying Cao, Han Wang, Yangyang Yu, Na Jiao and Zongfeng Zhang
    Citation: Stem Cell Research & Therapy 2022 13:294

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