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  1. Clinical applications have shown extracellular vesicles (EVs) to be a major paracrine effector in therapeutic responses produced by human mesenchymal stromal/stem cells (hMSCs). As the regenerative capacity of...

    Authors: Afnan Munshi, Jelica Mehic, Marybeth Creskey, Jonathan Gobin, Jun Gao, Emma Rigg, Gauri Muradia, Christian C. Luebbert, Carole Westwood, Andrew Stalker, David S. Allan, Michael J. W. Johnston, Terry Cyr, Michael Rosu-Myles and Jessie R. Lavoie

    Citation: Stem Cell Research & Therapy 2019 10:401

    Content type: Research

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  2. Myocardial infarction (MI) is a severe disease with increased mortality and disability rates, posing heavy economic burden for society. Exosomes were uncovered to mediate intercellular communication after MI. ...

    Authors: Qing Mao, Xiu-Lin Liang, Chuan-Long Zhang, Yi-Heng Pang and Yong-Xiang Lu

    Citation: Stem Cell Research & Therapy 2019 10:393

    Content type: Research

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  3. Chondrogenesis represents a highly dynamic cellular process that leads to the establishment of various types of cartilage. However, when stress-related injuries occur, a rapid and efficient regeneration of the...

    Authors: Lynda Bourebaba, Izabela Michalak, Meriem Baouche, Katarzyna Kucharczyk and Krzysztof Marycz

    Citation: Stem Cell Research & Therapy 2019 10:392

    Content type: Research

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  4. Methods based on site-specific recombinases are widely used in studying gene activities in vivo and in vitro. In these studies, constitutively active or inducible variants of these recombinases are expressed u...

    Authors: Andrey A. Kuzmin, Veronika V. Ermakova, Sergey A. Sinenko, Sergey V. Ponomartsev, Tatiana Y. Starkova, Elena V. Skvortsova, Olga Cherepanova and Alexey N. Tomilin

    Citation: Stem Cell Research & Therapy 2019 10:391

    Content type: Short report

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  5. Spinal cord injury (SCI) is a complex and severe neurological condition. Mesenchymal stem cells (MSCs) and their secreted factors show promising potential for regenerative medicine. Many studies have investiga...

    Authors: Ya-Tzu Chen, May-Jywan Tsai, Nini Hsieh, Ming-Jei Lo, Meng-Jen Lee, Henrich Cheng and Wen-Cheng Huang

    Citation: Stem Cell Research & Therapy 2019 10:390

    Content type: Research

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  6. Neural tube defects (NTDs) are the most serious and common birth defects in the clinic. The SRY-related HMG box B1 (SoxB1) gene family has been implicated in different processes of early embryogenesis. Sox19b ...

    Authors: Xian Li, Wenjuan Zhou, Xinyue Li, Ming Gao, Shufang Ji, Wenyu Tian, Guangyu Ji, Jingyi Du and Aijun Hao

    Citation: Stem Cell Research & Therapy 2019 10:389

    Content type: Research

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  7. Animal cell-based systems have been critical tools in understanding tissue development and physiology, but they are less successful in more practical tasks, such as predicting human toxicity to pharmacological...

    Authors: Alessandro Pirosa, Karen L. Clark, Jian Tan, Shuting Yu, Yuanheng Yang, Rocky S. Tuan and Peter G. Alexander

    Citation: Stem Cell Research & Therapy 2019 10:388

    Content type: Research

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  8. Incomplete recovery from acute kidney injury (AKI) can result in long-term functional deficits and has been recognized as a major contributor to chronic kidney disease (CKD), which is termed the AKI-CKD transi...

    Authors: Lingfei Zhao, Fei Han, Junni Wang and Jianghua Chen

    Citation: Stem Cell Research & Therapy 2019 10:385

    Content type: Review

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  9. MicroRNA (miR)-containing exosomes released by acute myeloid leukemia (AML) cells can be delivered into hematopoietic progenitor cells to suppress normal hematopoiesis. Herein, our study was performed to evalu...

    Authors: Chen Zhao, Feng Du, Yang Zhao, Shanshan Wang and Ling Qi

    Citation: Stem Cell Research & Therapy 2019 10:384

    Content type: Research

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  10. Radiation dermatitis is a refractory skin injury caused by radiotherapy. Human fetal skin-derived stem cell (hFSSC) is a preferable source for cell therapy and skin tissue regeneration. In the present study, w...

    Authors: Xiaoli Rong, Jiannan Li, Yanyan Yang, Liyan Shi and Tiechao Jiang

    Citation: Stem Cell Research & Therapy 2019 10:383

    Content type: Research

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  11. Spermatogonial stem cell (SSC) transplantation technology as a promising option for male fertility preservation has received increasing attention, along with efficient SSC purification technology as a necessar...

    Authors: Jia Tian, Ke Ma, Cheng-bin Pei, Shao-hua Zhang, Xue Li, Yue Zhou, Bei Yan, Hong-yan Wang and Liang-hong Ma

    Citation: Stem Cell Research & Therapy 2019 10:382

    Content type: Research

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  12. Mesenchymal stem cells (MSCs) play a significant role in cancer initiation and metastasis, sometimes by releasing exosomes that mediate cell communication by delivering microRNAs (miRNAs). This study aimed to ...

    Authors: Haiyang Xu, Guifang Zhao, Yu Zhang, Hong Jiang, Weiyao Wang, Donghai Zhao, Jin Hong, Hongquan Yu and Ling Qi

    Citation: Stem Cell Research & Therapy 2019 10:381

    Content type: Research

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  13. Spinal cord injury (SCI) results in glial scar formation and irreversible neuronal loss, which finally leads to functional impairments and long-term disability. Our previous studies have demonstrated that the ...

    Authors: Masoumeh Zarei-Kheirabadi, Mahdi Hesaraki, Sahar Kiani and Hossein Baharvand

    Citation: Stem Cell Research & Therapy 2019 10:380

    Content type: Research

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  14. Restoration of massive bone defects remains a huge challenge for orthopedic surgeons. Insufficient vascularization and slow bone regeneration limited the application of tissue engineering in bone defect. The e...

    Authors: Jingyuan Chen, Chang Tu, Xiangyu Tang, Hao Li, Jiyuan Yan, Yongzhuang Ma, Hua Wu and Chaoxu Liu

    Citation: Stem Cell Research & Therapy 2019 10:379

    Content type: Research

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  15. Magnesium (Mg2+)-enriched microenvironment promotes odontogenic differentiation in human dental pulp stem cells (DPSCs), but the regulatory mechanisms remain undefined. The aim of this work was to assess magnesiu...

    Authors: Yuanyuan Kong, Xiaoli Hu, Yingqun Zhong, Ke Xu, Buling Wu and Jianmao Zheng

    Citation: Stem Cell Research & Therapy 2019 10:378

    Content type: Research

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  16. Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into several tissues, such as bone, cartilage, and fat. Glucocorticoids affect a variety of biological processes such as prolifera...

    Authors: Lizhi Han, Bo Wang, Ruoyu Wang, Song Gong, Guo Chen and Weihua Xu

    Citation: Stem Cell Research & Therapy 2019 10:377

    Content type: Review

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  17. The umbilical cord blood (UCB) has been widely accepted as an alternative source of hematopoietic stem/progenitor cells (HSPCs) for transplantation, and its use in adults is still restricted because of low abs...

    Authors: Qiuyang Li, Dewan Zhao, Qiang Chen, Maowen Luo, Jingcao Huang, Cao Yang, Fangfang Wang, Wenxian Li and Ting Liu

    Citation: Stem Cell Research & Therapy 2019 10:376

    Content type: Research

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  18. Aspirin has been demonstrated to promote osteoblast-mediated bone formation and inhibit osteoclast (OC)-mediated bone resorption. However, it remains unclear whether aspirin influences other immune cells durin...

    Authors: Lili Wu, Zhenhua Luo, Yitong Liu, Lu Jia, Yiyang Jiang, Juan Du, Lijia Guo, Yuxing Bai and Yi Liu

    Citation: Stem Cell Research & Therapy 2019 10:375

    Content type: Research

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  19. Limbal stem cells (LSC) sustain the corneal integrity and homeostasis. LSC deficiency (LSCD) leads to loss of corneal transparency and blindness. A clinical approach to treat unilateral LSCD comprises autologo...

    Authors: Nuria Nieto-Nicolau, Eva M. Martínez-Conesa, Alba M. Velasco-García, Caterina Aloy-Reverté, Anna Vilarrodona and Ricardo P. Casaroli-Marano

    Citation: Stem Cell Research & Therapy 2019 10:374

    Content type: Research

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  20. Delivery of stem cells to the failing heart is a promising therapeutic strategy. However, the improvement in cardiac function in animal studies has not fully translated to humans. To help bridge the gap betwee...

    Authors: Jack F. Murphy, Joshua Mayourian, Francesca Stillitano, Sadek Munawar, Kathleen M. Broughton, Esperanza Agullo-Pascual, Mark A. Sussman, Roger J. Hajjar, Kevin D. Costa and Irene C. Turnbull

    Citation: Stem Cell Research & Therapy 2019 10:373

    Content type: Research

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  21. Mesenchymal stem cells (MSCs) have been shown to alleviate acute lung injury (ALI) via paracrine hepatocyte growth factor (HGF) and to induce the differentiation of dendritic cells (DCs) into tolerogenic dendr...

    Authors: Zhonghua Lu, Wei Chang, Shanshan Meng, Xiuping Xu, Jianfeng Xie, Fengmei Guo, Yi Yang, Haibo Qiu and Ling Liu

    Citation: Stem Cell Research & Therapy 2019 10:372

    Content type: Research

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  22. Mesenchymal stromal cells (MSCs), due to their regenerative and immunomodulatory properties, are therapeutically used for diseases, including heart failure. As early gestational-phase embryonic tissues exhibit...

    Authors: Karl-Henrik Grinnemo, Marie Löfling, Lubov Nathanson, Roland Baumgartner, Daniel F. J. Ketelhuth, Vladimir Beljanski, Lindsay C. Davies and Cecilia Österholm

    Citation: Stem Cell Research & Therapy 2019 10:371

    Content type: Research

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  23. We have recently demonstrated that amniotic fluid stem cells (AFSC) express renal progenitor markers and can be differentiated in vitro into renal lineage cell types, viz, juxtaglomerular and renal proximal tu...

    Authors: Ekta Minocha, Rohit Anthony Sinha, Manali Jain, Chandra Prakash Chaturvedi and Soniya Nityanand

    Citation: Stem Cell Research & Therapy 2019 10:370

    Content type: Research

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  24. Cartilage tissue engineering is a promising technique for repairing cartilage defect. Due to the limitation of cell number and proliferation, mesenchymal stem cells (MSCs) have been developed as a substitute t...

    Authors: Imam Rosadi, Karina Karina, Iis Rosliana, Siti Sobariah, Irsyah Afini, Tias Widyastuti and Anggraini Barlian

    Citation: Stem Cell Research & Therapy 2019 10:369

    Content type: Research

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  25. Gingiva-derived mesenchymal stem cells (GMSCs) obtained multipotent differentiation and immunomodulatory properties. However, collecting healthy gingival tissues may be challenging in the clinical situation. T...

    Authors: Tingting Yu, Boxi Yan, Jing Li, Ting Zhang, Ruili Yang, Xuedong Wang, Yan Liu and Dawei Liu

    Citation: Stem Cell Research & Therapy 2019 10:368

    Content type: Research

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  26. Anal sphincter injury leads to fecal incontinence. Based on the regenerative capability of laser and human adipose-derived stem cells (hADSCs), this study was designed to assess the effects of co-application o...

    Authors: Arash Sarveazad, Asrin Babahajian, Abazar Yari, Chris K. Rayner, Marjan Mokhtare, Arash Babaei-Ghazani, Shahram Agah, Bahar Mahjoubi, Jebreil Shamseddin and Mahmoud Yousefifard

    Citation: Stem Cell Research & Therapy 2019 10:367

    Content type: Research

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  27. The airways of mammalian lung are lined with highly specialized cell types that are the target of airborne toxicants and injury. Several epithelial cell types and bone marrow-derived mesenchymal stem cells hav...

    Authors: Suyun Fang, Suhong Zhang, Haiting Dai, Xiaoxiang Hu, Changgong Li and Yiming Xing

    Citation: Stem Cell Research & Therapy 2019 10:366

    Content type: Research

    Published on:

  28. Inner ear supporting cells (SCs) in the neonatal mouse cochlea are a potential source for hair cell (HC) regeneration, but several studies have shown that the regeneration ability of SCs decreases dramatically...

    Authors: Cheng Cheng, Yunfeng Wang, Luo Guo, Xiaoling Lu, Weijie Zhu, Waqas Muhammad, Liyan Zhang, Ling Lu, Junyan Gao, Mingliang Tang, Fangyi Chen, Xia Gao, Huawei Li and Renjie Chai

    Citation: Stem Cell Research & Therapy 2019 10:365

    Content type: Research

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  29. The limited proliferative ability of hepatocytes is a major limitation to meet their demand for cell-based therapy, bio-artificial liver device, and drug tests. One strategy is to amplify cells at the hepatobl...

    Authors: Tingcai Pan, Yan Chen, Yuanqi Zhuang, Fan Yang, Yingying Xu, Jiawang Tao, Kai You, Ning Wang, Yuhang Wu, Xianhua Lin, Feima Wu, Yanli Liu, Yingrui Li, Guodong Wang and Yin-xiong Li

    Citation: Stem Cell Research & Therapy 2019 10:364

    Content type: Research

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  30. Diabetic nephropathy (DN) is one of the most severe chronic diabetic complications and the main cause of end-stage renal disease. Chronic inflammation plays a key role in the development of DN. However, few tr...

    Authors: Xingxing An, Guangneng Liao, Younan Chen, Ai Luo, Jingping Liu, Yujia Yuan, Lan Li, Lichuan Yang, Hong Wang, Fang Liu, Guang Yang, Shounan Yi, Yuanmin Li, Jingqiu Cheng and Yanrong Lu

    Citation: Stem Cell Research & Therapy 2019 10:363

    Content type: Research

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  31. With the development of regenerative medicine and tissue engineering technology, almost all stem cell therapy is efficacious for the treatment of premature ovarian failure (POF) or premature ovarian insufficie...

    Authors: Boxian Huang, Chunfeng Qian, Chenyue Ding, Qingxia Meng, Qinyan Zou and Hong Li

    Citation: Stem Cell Research & Therapy 2019 10:362

    Content type: Research

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  32. The composition and function of the adipose tissue covering the heart are poorly known. In this study, we have investigated the epicardial adipose tissue (EAT) covering the cardiac ventricular muscle and the E...

    Authors: Carmen Lambert, Gemma Arderiu, Maria Teresa Bejar, Javier Crespo, Maribel Baldellou, Oriol Juan-Babot and Lina Badimon

    Citation: Stem Cell Research & Therapy 2019 10:361

    Content type: Research

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  33. Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs, and phospholipids, and are a novel mechanism of intercellular communication. It has been proposed that the immunomodulator...

    Authors: Guanguan Qiu, Guoping Zheng, Menghua Ge, Jiangmei Wang, Ruoqiong Huang, Qiang Shu and Jianguo Xu

    Citation: Stem Cell Research & Therapy 2019 10:359

    Content type: Review

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  34. The therapeutic potential of mesenchymal stem cells (MSCs) may be attributed partly to the secreted paracrine factors, which comprise exosomes. Exosomes are small, saucer-shaped vesicles containing miRNAs, mRN...

    Authors: Kun Yang, Dong Li, Meitian Wang, Zhiliang Xu, Xiao Chen, Qiao Liu, Wenjie Sun, Jiangxia Li, Yaoqin Gong, Duo Liu, Changshun Shao, Qiji Liu and Xi Li

    Citation: Stem Cell Research & Therapy 2019 10:358

    Content type: Research

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  35. The degenerative disc disease (DDD) is a major cause of low back pain. The physiological low-glucose microenvironment of the cartilage endplate (CEP) is disrupted in DDD. Glucose influences protein O-GlcNAcylatio...

    Authors: Chao Sun, Weiren Lan, Bin Li, Rui Zuo, Hui Xing, Minghan Liu, Jie Li, Yuan Yao, Junlong Wu, Yu Tang, Huan Liu and Yue Zhou

    Citation: Stem Cell Research & Therapy 2019 10:357

    Content type: Research

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  36. Orthopaedic diseases are one of the major targets for regenerative medicine. In this context, Wharton’s jelly (WJ) is an alternative source to bone marrow (BM) for allogeneic transplantation since its isolatio...

    Authors: Raquel Cabrera-Pérez, Marta Monguió-Tortajada, Ana Gámez-Valero, Raquel Rojas-Márquez, Francesc Enric Borràs, Santiago Roura and Joaquim Vives

    Citation: Stem Cell Research & Therapy 2019 10:356

    Content type: Research

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  37. White adipose tissue includes subcutaneous and visceral adipose tissue (SAT and VAT) with different metabolic features. SAT protects from metabolic disorders, while VAT promotes them. The proliferative and adi...

    Authors: Zhenzhen Pan, Zixin Zhou, Huiying Zhang, Hui Zhao, Peixuan Song, Di Wang, Jilong Yin, Wanyi Zhao, Zhaoxiang Xie, Fuwu Wang, Yan Li, Chun Guo, Faliang Zhu, Lining Zhang and Qun Wang

    Citation: Stem Cell Research & Therapy 2019 10:355

    Content type: Research

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  38. Mesenchymal stem cells are heterogenous populations with hematopoietic supporting and immunomodulating capacities. Enormous studies have focused on their preclinical or clinical therapeutic effects, yet the sy...

    Authors: Qinjun Zhao, Leisheng Zhang, Yimeng Wei, Hao Yu, Linglin Zou, Jiali Huo, Hongju Yang, Baoquan Song, Teng Wei, Dan Wu, Wenxia Zhang, Lei Zhang, Dengke Liu, Zongjin Li, Ying Chi, Zhibo Han…

    Citation: Stem Cell Research & Therapy 2019 10:354

    Content type: Research

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  39. In most stem cell therapy strategies reported to date, stem cells are introduced to damaged tissue sites to repair and regenerate the original tissue structure and function. MSC therapeutic efficacies are inco...

    Authors: Mitsuyoshi Nakao, Kyungsook Kim, Kenichi Nagase, David W. Grainger, Hideko Kanazawa and Teruo Okano

    Citation: Stem Cell Research & Therapy 2019 10:353

    Content type: Research

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  40. Traumatic brain injury (TBI) is a common neurotrauma leading to brain dysfunction and death. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) hold promise in the treatment of TBI. However, their ...

    Authors: Fangxia Guan, Tuanjie Huang, Xinxin Wang, Qu Xing, Kristyn Gumpper, Peng Li, Jishi Song, Tao Tan, Greta Luyuan Yang, Xingxing Zang, Jiewen Zhang, Yuming Wang, Yunlei Yang, Yashi Liu, Yanting Zhang, Bo Yang…

    Citation: Stem Cell Research & Therapy 2019 10:352

    Content type: Research

    Published on:

  41. Silicon-modified biomaterials have been extensively studied in bone tissue engineering. In recent years, the toxicity of silicon-doped biomaterials has gradually attracted attention but requires further elucid...

    Authors: Zheng Li, Shuhao Liu, Tengfei Fu, Yi Peng and Jian Zhang

    Citation: Stem Cell Research & Therapy 2019 10:351

    Content type: Research

    Published on:

  42. Human adipose-derived stem cells (hASCs) are a subset of mesenchymal stem cells (MSCs); it has been regarded as one of the most promising stem cells. We previously found that fibroblast growth factor-2 (FGF-2)...

    Authors: Yuanyuan Ma, Natsuko Kakudo, Naoki Morimoto, Fangyuan Lai, Shigeru Taketani and Kenji Kusumoto

    Citation: Stem Cell Research & Therapy 2019 10:350

    Content type: Research

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  43. Distinct mechanical stimuli are known to manipulate the behaviors of embryonic stem cells (ESCs). Fundamental rationale of how ESCs respond to mechanical forces and the potential biological effects remain elus...

    Authors: Jiawen Wang, Yi Wu, Xiao Zhang, Fan Zhang, Dongyuan Lü, Bing Shangguan, Yuxin Gao and Mian Long

    Citation: Stem Cell Research & Therapy 2019 10:349

    Content type: Research

    Published on:

  44. Bone marrow mesenchymal stem cells (BMSCs) can partially repair chemotherapy-induced ovarian damage. However, low survival rate after transplantation hampers the therapeutic efficiency of BMSCs. Heat shock pre...

    Authors: Qing Wang, Xinran Li, Qingru Wang, Jiaxin Xie, Chuhai Xie and Xiafei Fu

    Citation: Stem Cell Research & Therapy 2019 10:348

    Content type: Research

    Published on:

  45. Extracellular vesicles (EVs) are cellular-derived versatile transporters with a specialized property for trafficking a variety of cargo, including metabolites, growth factors, cytokines, proteins, lipids, and ...

    Authors: Mujib Ullah, Yang Qiao, Waldo Concepcion and Avnesh S. Thakor

    Citation: Stem Cell Research & Therapy 2019 10:347

    Content type: Review

    Published on:

  46. Osteoarthritis and cartilage injury treatment is an unmet clinical need. Therefore, development of new approaches to treat these diseases is critically needed. Previous work in our laboratory has shown that mu...

    Authors: Xueqin Gao, Haizi Cheng, Hassan Awada, Ying Tang, Sarah Amra, Aiping Lu, Xuying Sun, Guijin Lv, Charles Huard, Bing Wang, Xiaohong Bi, Yadong Wang and Johnny Huard

    Citation: Stem Cell Research & Therapy 2019 10:346

    Content type: Research

    Published on:

  47. An uncontrolled inflammatory response is a critical pathophysiological feature of sepsis. Mesenchymal stem cells (MSCs) induce macrophage phenotype polarization and reduce inflammation in sepsis. MSC-secreted ...

    Authors: Feng Liu, Haibo Qiu, Ming Xue, Shi Zhang, Xiwen Zhang, Jingyuan Xu, Jianxiao Chen, Yi Yang and Jianfeng Xie

    Citation: Stem Cell Research & Therapy 2019 10:345

    Content type: Research

    Published on:

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