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  1. Biomaterials used in bone tissue engineering must fulfill the requirements of osteoconduction, osteoinduction, and osseointegration. However, biomaterials with good osteoconductive properties face several chal...

    Authors: Bingqian Wang, Xinfang Xie, Wenbin Jiang, Yichen Zhan, Yifan Zhang, Yaqi Guo, Zhenxing Wang, Nengqiang Guo, Ke Guo and Jiaming Sun
    Citation: Stem Cell Research & Therapy 2024 15:135
  2. Human hematopoietic organoids have a wide application value for modeling human bone marrow diseases, such as acute hematopoietic radiation injury. However, the manufacturing of human hematopoietic organoids is...

    Authors: Keyi Chen, Yunqiao Li, Xumin Wu, Xuan Tang, Bowen Zhang, Tao Fan, Lijuan He, Xuetao Pei and Yanhua Li
    Citation: Stem Cell Research & Therapy 2024 15:133
  3. Induced pluripotent stem cells (iPSCs)-derived kidney organoids are a promising model for studying disease mechanisms and renal development. Despite several protocols having been developed, further improvement...

    Authors: Ekaterina Pecksen, Sergey Tkachuk, Cristoph Schröder, Marc Vives Enrich, Anindita Neog, Cory P. Johnson, Niko Lachmann, Hermann Haller and Yulia Kiyan
    Citation: Stem Cell Research & Therapy 2024 15:132
  4. Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) hold great therapeutic potential in regenerative medicine. Therefore, it is crucial to establish a Good Manufacturing Practice (GMP)-compliant methodolo...

    Authors: Wanglong Chu, Fen Zhang, Xiuping Zeng, Fangtao He, Guanyan Shang, Tao Guo, Qingfang Wang, Jianfu Wu, Tongjing Li, Zhen Zhong Zhong, Xiao Liang, Junyuan Hu and Muyun Liu
    Citation: Stem Cell Research & Therapy 2024 15:131
  5. Hyaluronan (HA) is an extracellular glycosaminoglycan polysaccharide with widespread roles throughout development and in healthy and neoplastic tissues. In pluripotent stem cell culture it can support both ste...

    Authors: Paul A. De Sousa, Leo Perfect, Jinpei Ye, Kay Samuels, Ewa Piotrowska, Martin Gordon, Ryan Mate, Elsa Abranches, Thomas M. Wishart, David H. Dockrell and Aidan Courtney
    Citation: Stem Cell Research & Therapy 2024 15:130
  6. Human bone marrow-derived stem cells (hBMDSCs) are well characterized mediators of tissue repair and regeneration. An increasing body of evidence indicates that these cells exert their therapeutic effects larg...

    Authors: Giulia Bonavina, Ramanaiah Mamillapalli, Graciela Krikun, Yuping Zhou, Nimisha Gawde and Hugh S. Taylor
    Citation: Stem Cell Research & Therapy 2024 15:129
  7. Testicular germ cell tumours (TGCTs) represent a clinical challenge; they are most prevalent in young individuals and are triggered by molecular mechanisms that are not fully understood. The origin of TGCTs ca...

    Authors: Ryan P Cardenas, Ahmad Zyoud, Alan McIntyre, Ramiro Alberio, Nigel P Mongan and Cinzia Allegrucci
    Citation: Stem Cell Research & Therapy 2024 15:128
  8. Endometria are one of the important components of the uterus, which is located in the peritoneal cavity. Endometrial injury usually leads to intrauterine adhesions (IUA), accompanied by inflammation and cell d...

    Authors: Jiali Wang, Jingman Li, Lijie Yin, Xiuzhu Wang, Yue Dong, Guangfeng Zhao, Sunan Shen and Yayi Hou
    Citation: Stem Cell Research & Therapy 2024 15:127
  9. Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for leukemia and a range of non-malignant disorders. The success of the therapy is hampered by occurrence of acute graft-versus...

    Authors: B. Yetkin-Arik, S. A. Jansen, S. Varderidou-Minasian, B. Westendorp, K.-P. Skarp, M. Altelaar, C. A. Lindemans and M. J. Lorenowicz
    Citation: Stem Cell Research & Therapy 2024 15:125
  10. Recombinant human bone morphogenetic protein 2 (rhBMP-2) and human bone marrow mesenchymal stromal cells (hBM-MSCs) have been thoroughly studied for research and translational bone regeneration purposes. rhBMP...

    Authors: Neda Kathami, Carolina Moreno-Vicente, Pablo Martín, Jhonatan A. Vergara-Arce, Raquel Ruiz-Hernández, Daniela Gerovska, Ana M. Aransay, Marcos J. Araúzo-Bravo, Sandra Camarero-Espinosa and Ander Abarrategi
    Citation: Stem Cell Research & Therapy 2024 15:124
  11. Acute radiation syndrome (ARS) manifests after exposure to high doses of radiation in the instances of radiologic accidents or incidents. Facilitating regeneration of the bone marrow (BM), namely the hematopoi...

    Authors: Justin Vercellino, Beata Małachowska, Shilpa Kulkarni, Brett I. Bell, Shahin Shajahan, Kosaku Shinoda, Gary Eichenbaum, Amit K. Verma, Sanchita P. Ghosh, Weng-Lang Yang, Paul S. Frenette and Chandan Guha
    Citation: Stem Cell Research & Therapy 2024 15:123
  12. Mesenchymal stem cells (MSCs) hold a great promise for cell-based therapy in the field of regenerative medicine. In this study, we aimed to evaluate the safety and efficacy of intravenous infusion of human umb...

    Authors: Yingqian Zhu, Ce Huang, Liang Zheng, Qingqing Li, Jianli Ge, ShaSha Geng, Miaomiao Zhai, Xin Chen, Huixiao Yuan, Yang Li, Wenwen Jia, Keping Sun, Yan Li, Tong Ye, Zhengmei Zhao, Hailiang Liu…
    Citation: Stem Cell Research & Therapy 2024 15:122
  13. Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer and, despite its adverse effects, chemotherapy is the standard systemic treatment option for TNBC. Since, it is of utmost import...

    Authors: Noemi Eiro, Maria Fraile, Sara Escudero-Cernuda, Juan Sendon-Lago, Luis O. Gonzalez, Maria Luisa Fernandez-Sánchez and Francisco J. Vizoso
    Citation: Stem Cell Research & Therapy 2024 15:121
  14. Diabetic cardiomyopathy (DCM) is a serious health-threatening complication of diabetes mellitus characterized by myocardial fibrosis and abnormal cardiac function. Human umbilical cord mesenchymal stromal cell...

    Authors: Boxin Liu, Yan Wei, Jingjing He, Baofeng Feng, Yimeng Chen, Ruiyun Guo, Matthew D. Griffin, Seán O. Hynes, Sanbing Shen, Yan Liu, Huixian Cui, Jun Ma and Timothy O’Brien
    Citation: Stem Cell Research & Therapy 2024 15:120
  15. Adipose stromal cells (ASC) are a form of mesenchymal stromal cells that elicit effects primarily via secreted factors, which may have advantages for the treatment of injury or disease. Several previous studie...

    Authors: Md Mahbub Ullah, Jason A. Collett, Jacob C. Monroe, Dmitry Traktuev, Michael Coleman, Keith L. March and David P. Basile
    Citation: Stem Cell Research & Therapy 2024 15:119
  16. Cerebral organoids (COs) are the most advanced in vitro models that resemble the human brain. The use of COs as a model for Alzheimer’s disease (AD), as well as other brain diseases, has recently gained attent...

    Authors: Mu Seog Choe, Han Cheol Yeo, Joong Sun Kim, Jean Lee, Hae Jun Lee, Hyung-Ryong Kim, Kyung Min Baek, Na-Yeon Jung, Murim Choi and Min Young Lee
    Citation: Stem Cell Research & Therapy 2024 15:118
  17. The detection rate of superficial non-ampullary duodenal epithelial tumors (SNADETs) has recently been increasing. Large tumors may contain malignant lesions and early therapeutic intervention is recommended. ...

    Authors: Kengo Kanetaka, Yasuhiro Maruya, Miki Higashi, Shun Yamaguchi, Ryo Matsumoto, Shinichiro Kobayashi, Keiichi Hashiguchi, Fumiya Oohashi, Masaki Matsumura, Takahiro Naka, Yusuke Sakai, Kazuhiko Nakao, Shigeru Miyagawa and Susumu Eguchi
    Citation: Stem Cell Research & Therapy 2024 15:117
  18. Haploid cells are a kind of cells with only one set of chromosomes. Compared with traditional diploid cells, haploid cells have unique advantages in gene screening and drug-targeted therapy, due to their pheno...

    Authors: Hai-Song Wang, Xin-Rui Ma and Yi-Hong Guo
    Citation: Stem Cell Research & Therapy 2024 15:116
  19. Studies have shown that chemotherapy and radiotherapy can cause premature ovarian failure and loss of fertility in female cancer patients. Ovarian cortex cryopreservation is a good choice to preserve female fe...

    Authors: Jiazhao Li, Haonan Fan, Wei Liu, Jing Zhang, Yue Xiao, Yue Peng, Weijie Yang, Wenwen Liu, Yuanlin He, Lianju Qin, Xiang Ma and Jing Li
    Citation: Stem Cell Research & Therapy 2024 15:115
  20. Spinal cord injury (SCI) is an intractable neurological disease in which functions cannot be permanently restored due to nerve damage. Stem cell therapy is a promising strategy for neuroregeneration after SCI....

    Authors: Jang-Woon Kim, Juryun Kim, Hyunkyung Mo, Heeju Han, Yeri Alice Rim and Ji Hyeon Ju
    Citation: Stem Cell Research & Therapy 2024 15:114
  21. Oral submucous fibrosis (OSF) is a precancerous lesion characterized by fibrous tissue deposition, the incidence of which correlates positively with the frequency of betel nut chewing. Prolonged betel nut chew...

    Authors: S. Y. Wang, S. J. Zhang, H. F. Meng, H. Q. Xu, Z. X. Guo, J. F. Yan, J. L. Gao, L. N. Niu, S. L. Wang and K. Jiao
    Citation: Stem Cell Research & Therapy 2024 15:113
  22. Mesenchymal stem/stromal cells (MSCs) are a promising therapeutic tool in cell therapy and tissue engineering because of their multi-lineage differentiation capacity, immunomodulatory effects, and tissue prote...

    Authors: Ghada Maged, Menna A. Abdelsamed, Hongjun Wang and Ahmed Lotfy
    Citation: Stem Cell Research & Therapy 2024 15:112
  23. Graft failure (GF) is a rare but serious complication after allogeneic hematopoietic stem cell transplantation (HSCT). Prevention of graft failure remains the most advisable approach as there is no clear recom...

    Authors: Tahereh Rostami, Mohammad Reza Rostami, Amir Hossein Mirhosseini, Saeed Mohammadi, Mohsen Nikbakht, Hediyeh Alemi, Naghmeh Khavandgar, Soroush Rad, Ghasem Janbabai, Seied Asadollah Mousavi, Azadeh Kiumarsi and Amir Kasaeian
    Citation: Stem Cell Research & Therapy 2024 15:111
  24. The STROMA-CoV-2 study was a French phase 2b, multicenter, double-blind, randomized, placebo-controlled clinical trial that did not identify a significant efficacy of umbilical cord-derived mesenchymal stromal...

    Authors: Alexandre Sitbon, Caroline Hauw-Berlemont, Miryam Mebarki, Nicholas Heming, Julien Mayaux, Jean-Luc Diehl, Alexandre Demoule, Djillali Annane, Clémence Marois, Sophie Demeret, Emmanuel Weiss, Guillaume Voiriot, Muriel Fartoukh, Jean‐Michel Constantin, Bruno Mégarbane, Gaëtan Plantefève…
    Citation: Stem Cell Research & Therapy 2024 15:109
  25. Epilepsy affects ∼60 million people worldwide. Most antiseizure medications in the market act on voltage-gated sodium or calcium channels, indirectly modulating neurotransmitter GABA or glutamate levels or mul...

    Authors: Abhijna Ballal R, Shivakumar Reddy K, Divya Chandran, Sumukha Hegde, Raghavendra Upadhya, Praveen Kumar SE, Smita Shenoy, Vasudha Devi and Dinesh Upadhya
    Citation: Stem Cell Research & Therapy 2024 15:108
  26. The detailed transcriptomic profiles during human serotonin neuron (SN) differentiation remain elusive. The establishment of a reporter system based on SN terminal selector holds promise to produce highly-puri...

    Authors: Yingqi Li, Jinjin Duan, You Li, Meihui Zhang, Jiaan Wu, Guanhao Wang, Shuanqing Li, Zhangsen Hu, Yi Qu, Yunhe Li, Xiran Hu, Fei Guo, Lining Cao and Jianfeng Lu
    Citation: Stem Cell Research & Therapy 2024 15:107
  27. Although oncogenic RAS mutants are thought to exert mutagenic effects upon blood cells, it remains uncertain how a single oncogenic RAS impacts non-transformed multipotent hematopoietic stem or progenitor cells (...

    Authors: Huan-Ting Lin, Masatoshi Takagi, Kenji Kubara, Kazuto Yamazaki, Fumiko Michikawa, Takashi Okumura, Takuya Naruto, Tomohiro Morio, Koji Miyazaki, Hideki Taniguchi and Makoto Otsu
    Citation: Stem Cell Research & Therapy 2024 15:106
  28. Acute hypoxic proximal tubule (PT) injury and subsequent maladaptive repair present high mortality and increased risk of acute kidney injury (AKI) - chronic kidney disease (CKD) transition. Human bone marrow m...

    Authors: Sefa Burak Çam, Eda Çiftci, Nazlıhan Gürbüz, Bülent Altun and Petek Korkusuz
    Citation: Stem Cell Research & Therapy 2024 15:105
  29. Microglia, the brain’s resident immune cells, play vital roles in brain development, and disorders like Alzheimer’s disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these pro...

    Authors: Imdadul Haq, Jason C. Ngo, Nainika Roy, Richard L. Pan, Nadiya Nawsheen, Rebecca Chiu, Ya Zhang, Masashi Fujita, Rajesh K. Soni, Xuebing Wu, David A. Bennett, Vilas Menon, Marta Olah and Falak Sher
    Citation: Stem Cell Research & Therapy 2024 15:104
  30. Oral ulcers are a common side effect of chemotherapy and affect patients’ quality of life. While stem cell transplantation is a potential treatment for oral ulcers, its efficacy is limited as the stem cells te...

    Authors: Hyun Seok Ryu, Celine Abueva, Andrew Padalhin, So Young Park, Seung Hyeon Yoo, Hwee Hyon Seo, Phil-Sang Chung and Seung Hoon Woo
    Citation: Stem Cell Research & Therapy 2024 15:103
  31. Premature ovarian insufficiency (POI) is a major cause of infertility. In this study, we aimed to investigate the effects of the combination of bone marrow mesenchymal stem cells (BMSCs) and moxibustion (BMSCs...

    Authors: Ge Lu, Hong-xiao Li, Zi-wei Song, Jia Luo, Yan-liang Fan, Yao-li Yin, Jie Shen and Mei-hong Shen
    Citation: Stem Cell Research & Therapy 2024 15:102
  32. In response to the growing demand for organ substitutes, tissue engineering has evolved significantly. However, it is still challenging to create functional tissues and organs. Tissue engineering from the ‘bot...

    Authors: Yichen Zhan, Wenbin Jiang, Zhirong Liu, Zhenxing Wang, Ke Guo and Jiaming Sun
    Citation: Stem Cell Research & Therapy 2024 15:101
  33. Erythroid and myeloid differentiation disorders are commonly occurred in leukemia. Given that the relationship between erythroid and myeloid lineages is still unclear. To find the co-regulators in erythroid an...

    Authors: Yimeng Zhang, Ya Zhou, Xiaohong Li, Xu Pan, Ju Bai, Yijin Chen, Zhenyang Lai, Qiang Chen, Feng Ma and Yong Dong
    Citation: Stem Cell Research & Therapy 2024 15:100
  34. Human induced pluripotent stem cell (iPSC)-derived peripheral sensory neurons present a valuable tool to model human diseases and are a source for applications in drug discovery and regenerative medicine. Clin...

    Authors: Anil Kumar Kalia, Corinna Rösseler, Rafael Granja-Vazquez, Ayesha Ahmad, Joseph J. Pancrazio, Anika Neureiter, Mei Zhang, Daniel Sauter, Irina Vetter, Asa Andersson, Gregory Dussor, Theodore J. Price, Benedict J. Kolber, Vincent Truong, Patrick Walsh and Angelika Lampert
    Citation: Stem Cell Research & Therapy 2024 15:99
  35. In vitro chondrogenesis of mesenchymal stromal cells (MSCs) driven by the essential chondro-inducer transforming growth factor (TGF)-β is instable and yields undesired hypertrophic cartilage predisposed to bon...

    Authors: Solvig Diederichs, Simon I. Dreher, Sarah Anna Nüesch, Sven Schmidt, Christian Merle and Wiltrud Richter
    Citation: Stem Cell Research & Therapy 2024 15:98
  36. DNA damage and oxidative stress induced by chemotherapy are important factors in the onset of premature ovarian insufficiency (POI). Studies have shown that mitochondria derived from mesenchymal stem cells (MS...

    Authors: Shengjie Liu, Yuanmei Wang, Hanlin Yang, Jun Tan, Jingkaiwen Zhang and Dan Zi
    Citation: Stem Cell Research & Therapy 2024 15:97
  37. Ovarian ageing is one of the major issues that impacts female fertility. Mesenchymal stem cell (MSC)-based therapy has made impressive progress in recent years. However, the efficacy and safety of MSCs, as non...

    Authors: Wendi Pei, Lin Fu, Wenhuan Guo, Yibo Wang, Yong Fan, Rui Yang, Rong Li, Jie Qiao and Yang Yu
    Citation: Stem Cell Research & Therapy 2024 15:96
  38. Human adipose stromal cells-derived extracellular vesicles (haMSC-EVs) have been shown to alleviate inflammation in acute lung injury (ALI) animal models. However, there are few systemic studies on clinical-gr...

    Authors: Jing Wang, Zhong-jin Chen, Ze-yi Zhang, Mei-ping Shen, Bo Zhao, Wei Zhang, Ye Zhang, Ji-gang Lei, Cheng-jie Ren, Jing Chang, Cui-li Xu, Meng Li, Yang-yang Pi, Tian-lun Lu, Cheng-xiang Dai, Su-ke Li…
    Citation: Stem Cell Research & Therapy 2024 15:95
  39. Spinal Muscular Atrophy (SMA) is an autosomal-recessive neuromuscular disease affecting children. It is caused by the mutation or deletion of the survival motor neuron 1 (SMN1) gene resulting in lower motor neuro...

    Authors: Federica Virla, Ermanna Turano, Ilaria Scambi, Lorenzo Schiaffino, Marina Boido and Raffaella Mariotti
    Citation: Stem Cell Research & Therapy 2024 15:94

    The Correction to this article has been published in Stem Cell Research & Therapy 2024 15:126

  40. Spermatogonial stem cells (SSCs) were considered to be stem cells with limited potencies due to their existence in adult organisms. However, the production of spermatogonial stem cell colonies with broader dif...

    Authors: Sivankutty Indu, Anandavally N. Devi, Mahitha Sahadevan, Jeeva Sengottaiyan, Asmita Basu, Shabith Raj K and Pradeep G. Kumar
    Citation: Stem Cell Research & Therapy 2024 15:93
  41. Previously, we have demonstrated that the batch variations of human platelet lysate (conventional MSC expansion medium) induce MSC heterogeneity and therapeutic inconsistency. On the other hand, the MSCs expan...

    Authors: Shaoquan Shi, Si Chen, Bowei Liang, Yumeng Li, Qi Ma, Meiqi Li, Jingting Zhang, Lan Yao and Jianyong Xu
    Citation: Stem Cell Research & Therapy 2024 15:92
  42. Musculoskeletal disorders are the leading causes of physical disabilities worldwide. The poor self-repair capacity of musculoskeletal tissues and the absence of effective therapies have driven the development ...

    Authors: Chenrui Yuan, Wei Song, Xiping Jiang, Yifei Wang, Chenkai Li, Weilin Yu and Yaohua He
    Citation: Stem Cell Research & Therapy 2024 15:91
  43. Premature ovarian insufficiency (POI) is an essential cause of reduced fertility and quality of life in young women. Mesenchymal stem cells (MSCs) and MSCs-derived extracellular vesicles (EVs) have the ability...

    Authors: Yinhua Song, Jiachen Wu, Yang Liu, Na Xu, Hualin Bai, Lingjuan Wang, Jihui Ai and Kezhen Li
    Citation: Stem Cell Research & Therapy 2024 15:90
  44. Human pluripotent stem cells (hPSCs) have an enormous therapeutic potential, but large quantities of cells will need to be supplied by reliable, economically viable production processes. The suspension culture...

    Authors: Kevin Ullmann, Felix Manstein, Wiebke Triebert, Nils Kriedemann, Annika Franke, Jana Teske, Mira Mertens, Victoria Lupanow, Gudrun Göhring, Alexandra Haase, Ulrich Martin and Robert Zweigerdt
    Citation: Stem Cell Research & Therapy 2024 15:89
  45. Authors: Mathew Blurton-Jones, Brian Spencer, Sara Michael, Nicholas A. Castello, Andranik A. Agazaryan, Joy L. Davis, Franz-Josef Müller, Jeanne F. Loring, Eliezer Masliah and Frank M. LaFerla
    Citation: Stem Cell Research & Therapy 2024 15:88

    The original article was published in Stem Cell Research & Therapy 2014 5:46

  46. The clinical application of human bone-marrow derived mesenchymal stem cells (MSCs) for the treatment of refractory diseases has achieved remarkable results. However, there is a need for a systematic evaluatio...

    Authors: Miao Hao, Hongyu Jiang, Yuan Zhao, Chunyi Li and Jinlan Jiang
    Citation: Stem Cell Research & Therapy 2024 15:87
  47. In the study published by Sun et al., a systematic review and meta-analysis illustrated the advantageous of stem cell therapy in diabetic foot and can improve the quality of life of patients. Nevertheless, the...

    Authors: Yan Bai and Fan Zhang
    Citation: Stem Cell Research & Therapy 2024 15:85

    The original article was published in Stem Cell Research & Therapy 2022 13:416

    The Commentary to this article has been published in Stem Cell Research & Therapy 2024 15:86

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