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  1. Mesenchymal stem cells (MSCs) are pluripotent mesenchymal cells present in various adult tissues. MSCs secrete exosomes as regulators of the tumor niche, with involvement in tumorigenesis and metastasis. The r...

    Authors: Yuan Liang, Dalin Zhang, Linlin Li, Tian Xin, Yuwei Zhao, Rui Ma and Jiang Du

    Citation: Stem Cell Research & Therapy 2020 11:87

    Content type: Research

    Published on:

  2. Parthenogenetic stem cells (PSCs) are a promising source of regenerated cardiomyocytes; however, their application may be limited without a paternal genome. Insulin-like growth factor-II (IGF-II), a paternally...

    Authors: Yi Sui, Wei Zhang, Tao Tang, Lili Gao, Ting Cao, Hongbo Zhu, Qinghua You, Bo Yu and Tao Yang

    Citation: Stem Cell Research & Therapy 2020 11:86

    Content type: Research

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  3. Embryonic Sertoli cells (eSCs) have been known for playing important roles in male reproductive development system. In current studies, eSCs were mainly generated from induced intermediate mesoderm. The derivi...

    Authors: Chenze Xu, Yichen Dai, Ali Mohsin, Haifeng Hang, Yingping Zhuang and Meijin Guo

    Citation: Stem Cell Research & Therapy 2020 11:85

    Content type: Research

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  4. The cancer stem cell hypothesis is an old idea which has been revived in recent years for many cancers, including gliomas. However, this concept has become controversial due to a series of studies with conflic...

    Authors: Lei Zhang, Hongwei Yu, Yuhui Yuan, John S. Yu, Zhenkun Lou, Yixue Xue and Yunhui Liu

    Citation: Stem Cell Research & Therapy 2020 11:84

    Content type: Review

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  5. Autologous peripheral blood stem cell (auto-PBSC) transplantation is an effective therapeutic for the osteonecrosis of the femoral head (ONFH) but without prognosis estimation. This study mainly aimed to (1) d...

    Authors: Jiafei Pan, Quanwei Ding, Shuaijie Lv, Bingjiang Xia, Hongting Jin, Di Chen, Luwei Xiao and Peijian Tong

    Citation: Stem Cell Research & Therapy 2020 11:83

    Content type: Research

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  6. Many studies have elegantly shown that murine and rat bone marrow-derived mesenchymal stromal cells (bmMSCs) contribute to muscle regeneration and improve muscle function. Yet, the ability of transplanted huma...

    Authors: Dominik Barisic, Marita Erb, Marie Follo, Dahlia Al-Mudaris, Bernd Rolauffs and Melanie L. Hart

    Citation: Stem Cell Research & Therapy 2020 11:79

    Content type: Research

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  7. Keloid formation occurs in Caucasian, African, and Asian populations and is a severe psychosocial burden on patients. There is no permanent treatment for this problem as its pathogenesis is not properly unders...

    Authors: Subramanian Arjunan, Shu Uin Gan, Mahesh Choolani, Vaishnevi Raj, Jane Lim, Arijit Biswas, Ariff Bongso and Chui Yee Fong

    Citation: Stem Cell Research & Therapy 2020 11:78

    Content type: Research

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  8. Induced pluripotent stem cells (iPSCs) exhibit limitless pluripotent plasticity and proliferation capability to provide an abundant cell source for tissue regenerative medicine. Thus, inducing iPSCs toward a s...

    Authors: Yaqian Hu, Lei Chen, Yi Gao, Pengzhen Cheng, Liu Yang, Chengtie Wu and Qiang Jie

    Citation: Stem Cell Research & Therapy 2020 11:77

    Content type: Research

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  9. The unmet medical needs in repairing large muscle defects promote the development of tissue regeneration strategy. The use of bioactive molecules in combination with biomaterial scaffold has become an area of ...

    Authors: Yuanqiang Dong, Yuan Li, Chuan Zhang, Haibin Chen, Lijia Liu and Simeng Chen

    Citation: Stem Cell Research & Therapy 2020 11:76

    Content type: Research

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  10. Human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have shed great light on cardiac regenerative medicine and specifically myocardial repair in heart failure patients. However, the treatment...

    Authors: Xumin Guan, Wanzi Xu, He Zhang, Qian Wang, Jiuyang Yu, Ruyi Zhang, Yamin Chen, Yunlong Xia, Jiaxian Wang and Dongjin Wang

    Citation: Stem Cell Research & Therapy 2020 11:73

    Content type: Research

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  11. Generation of red blood cells (RBCs) from hematopoietic stem cells (HSCs) in vitro takes about 21 days, making it unaffordable for clinical applications. Acceleration of the in vitro erythropoiesis process by ...

    Authors: Rutuja Kuhikar, Nikhat Khan, Joseph Philip, Sameer Melinkeri, Vaijayanti Kale and Lalita Limaye

    Citation: Stem Cell Research & Therapy 2020 11:71

    Content type: Research

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  12. Mesenchymal stem cell-derived extracellular vesicles (EVs) are one of the most promising therapeutics in protective and/or regenerative therapy in animal models of stroke using a dose of 100 μg. However, wheth...

    Authors: Laura Otero-Ortega, Fernando Laso-García, Mari Carmen Gómez-de Frutos, Luke Diekhorst, Arturo Martínez-Arroyo, Elisa Alonso-López, María Laura García-Bermejo, Macarena Rodríguez-Serrano, Mercedes Arrúe-Gonzalo, Exuperio Díez-Tejedor, Blanca Fuentes and María Gutiérrez-Fernández

    Citation: Stem Cell Research & Therapy 2020 11:70

    Content type: Research

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  13. Transplantation of skeletal myoblast sheets is a promising strategy for the treatment of heart failure, and its therapeutic effects have already been proven in both animal disease models and clinical trials. M...

    Authors: Hiroko Iseoka, Shigeru Miyagawa, Atsuhiro Saito, Akima Harada and Yoshiki Sawa

    Citation: Stem Cell Research & Therapy 2020 11:69

    Content type: Research

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  14. Angiogenesis plays an important role in tissue repair and regeneration, and conditioned medium (CM) derived from mesenchymal stem cells (MSC-CM) possesses pro-angiogenesis. Nevertheless, the profile and concen...

    Authors: Shanshan Jin, Chengzhe Yang, Jiahui Huang, Lianlian Liu, Yu Zhang, Shutong Li, Liguo Zhang, Qinfeng Sun and Pishan Yang

    Citation: Stem Cell Research & Therapy 2020 11:68

    Content type: Research

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  15. NANOG functions as the gateway for the generation of pluripotent stem cells (PSCs) in mice and humans. NANOG is a transcription factor highly expressed in pig pre-implantation embryos, indicating that it is a con...

    Authors: Junjun Xu, Zheng Zheng, Xuguang Du, Bingbo Shi, Jichang Wang, Dengfeng Gao, Qianqian Zhu, Xinze Chen and Jianyong Han

    Citation: Stem Cell Research & Therapy 2020 11:67

    Content type: Research

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  16. Articular cartilage shows little or no capacity for intrinsic repair, generating a critical need of regenerative therapies for joint injuries and diseases such as osteoarthritis. Human-induced pluripotent stem...

    Authors: Amanda Dicks, Chia-Lung Wu, Nancy Steward, Shaunak S. Adkar, Charles A. Gersbach and Farshid Guilak

    Citation: Stem Cell Research & Therapy 2020 11:66

    Content type: Research

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  17. Somatic cell nuclear transfer (SCNT) has shown a wide application in the generation of transgenic animals, protection of endangered animals, and therapeutic cloning. However, the efficiency of SCNT remains ver...

    Authors: Pengxiang Qu, Yongsheng Wang, Chengsheng Zhang and Enqi Liu

    Citation: Stem Cell Research & Therapy 2020 11:65

    Content type: Review

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  18. Graft-versus-host disease (GvHD) is the main life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT). Thirty to 80% of GvHD patients do not respond to first-line treatment an...

    Authors: Cynthia Morata-Tarifa, María del Mar Macías-Sánchez, Antonio Gutiérrez-Pizarraya and Rosario Sanchez-Pernaute

    Citation: Stem Cell Research & Therapy 2020 11:64

    Content type: Research

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  19. The process of bone repair is heavily dependent on the ability of human bone marrow mesenchymal stem cells (hMSCs) to undergo osteogenic differentiation. MicroRNAs have been shown to regulate this osteogenic p...

    Authors: Tao Wang, Chao Zhang, Cihu Wu, Jianyun Liu, Hui Yu, Xiaoou Zhou, Jie Zhang, Xinping Wang, Shan He, Xiaoyuan Xu, Baicheng Ma, Xiangxin Che and Weidong Li

    Citation: Stem Cell Research & Therapy 2020 11:62

    Content type: Research

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  20. The homeostasis of oral pathogenic bacteria and probiotics plays a crucial role in maintaining the well-being and healthy status of human host. Our previous study confirmed that imbalanced oral microbiota coul...

    Authors: Nannan Han, Lu Jia, Lijia Guo, Yingying Su, Zhenhua Luo, Juan Du, Shenghui Mei and Yi Liu

    Citation: Stem Cell Research & Therapy 2020 11:61

    Content type: Research

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  21. Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. COPD results from chronic inflammation of the lungs. Current treatments, including physical and chemical therapies, p...

    Authors: Phuong Le Thi Bich, Ha Nguyen Thi, Hoang Dang Ngo Chau, Tien Phan Van, Quyet Do, Hung Dong Khac, Dong Le Van, Luc Nguyen Huy, Khan Mai Cong, Thang Ta Ba, Trung Do Minh, Ngoc Vu Bich, Nhat Truong Chau and Phuc Van Pham

    Citation: Stem Cell Research & Therapy 2020 11:60

    Content type: Research

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  22. Longitudinal studies have verified the pivotal role of mesenchymal stem/stromal cells (MSCs) in the bone marrow microenvironment for hematopoiesis and coordinate contribution to leukemia pathogenesis. However,...

    Authors: Jiali Huo, Leisheng Zhang, Xiang Ren, Chengwen Li, Xingxin Li, Peiyuan Dong, Xuan Zheng, Jinbo Huang, Yingqi Shao, Meili Ge, Jing Zhang, Min Wang, Neng Nie, Peng Jin and Yizhou Zheng

    Citation: Stem Cell Research & Therapy 2020 11:59

    Content type: Research

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  23. Skeletal unloading can induce severe disuse osteopenia that often occurs in spaceflight astronauts or in patients subjected to prolonged bed-rest or immobility. Previously, we revealed a mechano-sensitive fact...

    Authors: Zebing Hu, Lijun Zhang, Han Wang, Yixuan Wang, Yingjun Tan, Lei Dang, Ke Wang, Zhongyang Sun, Gaozhi Li, Xinsheng Cao, Shu Zhang, Fei Shi and Ge Zhang

    Citation: Stem Cell Research & Therapy 2020 11:58

    Content type: Research

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  24. The mechanisms by which macrophage phenotype contributes to mesenchymal stem cells (MSC)-mediated bone repair remain unclear. In this work, we investigated the influence of factors released by human macrophage...

    Authors: Gema Vallés, Fátima Bensiamar, Leila Maestro-Paramio, Eduardo García-Rey, Nuria Vilaboa and Laura Saldaña

    Citation: Stem Cell Research & Therapy 2020 11:57

    Content type: Research

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  25. Wound healing is a complex pathophysiological process that involves a variety of cells and cytokines. In this study, we found that local injection of human amnion mesenchymal stem cells into wounds in rats cou...

    Authors: Shaoying Gao, Tao Chen, Yi Hao, Feifei Zhang, Xiujun Tang, Dali Wang, Zairong Wei and Jianping Qi

    Citation: Stem Cell Research & Therapy 2020 11:56

    Content type: Research

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  26. In a number of disease processes, the body is unable to repair injured tissue, promoting the need to develop strategies for tissue repair and regeneration, including the use of cellular therapeutics. Trophobla...

    Authors: Minmin Hou, Junwen Han, Gu Li, Min-Young Kwon, Jiani Jiang, Sirisha Emani, Elizabeth S. Taglauer, Jin-Ah Park, Eun-Bee Choi, Munender Vodnala, Yick W. Fong, Sitaram M. Emani, Ivan O. Rosas, Mark A. Perrella and Xiaoli Liu

    Citation: Stem Cell Research & Therapy 2020 11:55

    Content type: Research

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  27. Due to the prominent role of the liver in the body and detoxification, its functionality can be affected in an irreversible manner by diseases. This phenomenon renders the liver to stop working, leading to mor...

    Authors: Afsoon Afshari, Sara Shamdani, Georges Uzan, Sina Naserian and Negar Azarpira

    Citation: Stem Cell Research & Therapy 2020 11:54

    Content type: Review

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  28. The simultaneous contribution of several etiopathogenic disturbances makes amyotrophic lateral sclerosis (ALS) a fatal and challenging disease. Here, we studied two different cell therapy protocols to protect ...

    Authors: Anna Martínez-Muriana, Diego Pastor, Renzo Mancuso, Amaya Rando, Rosario Osta, Salvador Martínez, Rubèn López-Vales and Xavier Navarro

    Citation: Stem Cell Research & Therapy 2020 11:53

    Content type: Research

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  29. Antibody production after allogeneic administration of mesenchymal stem cells (MSCs) could impact their clinical application. Proinflammatory priming of MSCs can potentiate their regulatory ability in vivo but...

    Authors: Laura Barrachina, Alina Cequier, Antonio Romero, Arantza Vitoria, Pilar Zaragoza, Francisco José Vázquez and Clementina Rodellar

    Citation: Stem Cell Research & Therapy 2020 11:52

    Content type: Research

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  30. Mesenchymal stem cell (MSC) transplantation is a fast-developing therapy in regenerative medicine. However, some concerns have been raised regarding their safety and the infusion-related pro-coagulant activity...

    Authors: Louise C. F. Coppin, Françoise Smets, Jérome Ambroise, Etienne E. M. Sokal and Xavier Stéphenne

    Citation: Stem Cell Research & Therapy 2020 11:51

    Content type: Research

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  31. Tissue expansion techniques play an important role in plastic surgery. How to improve the quality of the expanded skin and shorten the expansion period are still worth investigating. Our previous studies found...

    Authors: Mingwu Deng, Xiangsheng Wang, Ziyou Yu, Yizuo Cai, Wei Liu, Guangdong Zhou, Xiansong Wang, Zheyuan Yu, Wei Li and Wen Jie Zhang

    Citation: Stem Cell Research & Therapy 2020 11:50

    Content type: Research

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  32. Umbilical cord-derived mesenchymal stem cell (UCMSCs) transplantation has been widely studied in premature ovarian failure (POF). However, the underlying mechanism remains elusive. This study aims to investiga...

    Authors: Na Yin, Chenting Wu, Jianping Qiu, Yueming Zhang, Le Bo, Ying Xu, Mengdie Shi, Songyue Zhu, Guangzhao Yang and Caiping Mao

    Citation: Stem Cell Research & Therapy 2020 11:49

    Content type: Research

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  33. Lupus nephritis is usually manifested by proteinuria, active urinary sediment, hypertension, and renal failure and is a serious complication with more than 50% occurrence in systemic lupus erythematosus patien...

    Authors: Tianbiao Zhou, Chunling Liao, Hong-Yan Li, Wenshan Lin, Shujun Lin and Hongzhen Zhong

    Citation: Stem Cell Research & Therapy 2020 11:48

    Content type: Research

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  34. Despite increasing demand, current protocols for human pluripotent stem cell (hPSC)-derived retinal pigment epithelium (RPE) remain time, labor, and cost intensive. Additionally, absence of robust methods for ...

    Authors: Fabio Michelet, Aishwarya Balasankar, Nickolas Teo, Lawrence W. Stanton and Shweta Singhal

    Citation: Stem Cell Research & Therapy 2020 11:47

    Content type: Research

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  35. The mesenchymal stem cell (MSC) secretome, via the combined actions of its plethora of biologically active factors, is capable of orchestrating the regenerative responses of numerous tissues by both eliciting ...

    Authors: Dinesh Parate, Nurul Dinah Kadir, Cenk Celik, Eng Hin Lee, James H. P. Hui, Alfredo Franco-Obregón and Zheng Yang

    Citation: Stem Cell Research & Therapy 2020 11:46

    Content type: Research

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  36. Mesenchymal stromal cell (MSC) stemness capacity diminishes over prolonged in vitro culture, which negatively affects their application in regenerative medicine. To slow down the senescence of MSCs, here, we h...

    Authors: Mohammadhossein Khorraminejad-Shirazi, Mahsa Sani, Tahereh Talaei-Khozani, Mohammadreza Dorvash, Malihe Mirzaei, Mohammad Ali Faghihi, Ahmad Monabati and Armin Attar

    Citation: Stem Cell Research & Therapy 2020 11:45

    Content type: Research

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  37. Sepsis is a global inflammatory disease that causes death. It has been reported that mesenchymal stem cell (MSC) treatment can attenuate inflammatory and septic symptoms. In this study, we investigated how int...

    Authors: Sung Yong Ahn, Yong-Sun Maeng, Yu Rim Kim, Young Ho Choe, Han Sung Hwang and Young-Min Hyun

    Citation: Stem Cell Research & Therapy 2020 11:44

    Content type: Research

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  38. Cerebral palsy (CP) is a syndrome of childhood movement and posture disorders. Clinical evidence is still limited and sometimes inconclusive about the benefits of human umbilical cord mesenchymal stem cells (h...

    Authors: Jiaowei Gu, Li Huang, Che Zhang, Yong Wang, Ruibo Zhang, Ziliang Tu, Hengdong Wang, Xihui Zhou, Zhousheng Xiao, Zegan Liu, Xiang Hu, Zunchen Ke, Dabin Wang and Li Liu

    Citation: Stem Cell Research & Therapy 2020 11:43

    Content type: Research

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  39. Evidence has demonstrated conditioned medium (CM) from periodontal ligament stem cells (PDLSCs) improved periodontal regeneration. Gingival mesenchymal stem cells (GMSCs) have been considered an alternative st...

    Authors: Jiling Qiu, Xiaotong Wang, Haowen Zhou, Chunshu Zhang, Yijia Wang, Jiahui Huang, Meng Liu, Pishan Yang and Aimei Song

    Citation: Stem Cell Research & Therapy 2020 11:42

    Content type: Research

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  40. Alveolar bone loss is a frequent occurrence. Dental pulp stem cells (DPSCs) which have invasive accessibility and high osteogenic potential is a promising source for cell-based bone regeneration. EphrinB2 is i...

    Authors: Wen Wang, Changyong Yuan, Tengyu Geng, Yi Liu, Shaoyue Zhu, Chengfei Zhang, Zongxiang Liu and Penglai Wang

    Citation: Stem Cell Research & Therapy 2020 11:40

    Content type: Research

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  41. Chronic nonhealing wounds represent one of the most common complications of diabetes and require advanced treatment strategies. Increasing evidence supports the important role of mesenchymal stem cells in diab...

    Authors: Shichang Zhang, Li Chen, Guoying Zhang and Bo Zhang

    Citation: Stem Cell Research & Therapy 2020 11:39

    Content type: Research

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  42. As important players in cell-to-cell communication, exosomes (exo) are believed to play a similar role in promoting fracture healing. This study investigated whether exosomes derived from bone marrow mesenchym...

    Authors: Lu Zhang, Guangjun Jiao, Shanwu Ren, Xiaoqian Zhang, Ci Li, Wenliang Wu, Hongliang Wang, Haichun Liu, Hongming Zhou and Yunzhen Chen

    Citation: Stem Cell Research & Therapy 2020 11:38

    Content type: Research

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  43. Using a toxin-induced nonhuman primate model of acute liver failure (ALF), we previously reported that peripheral infusion of human umbilical cord mesenchymal stem cells (hUC-MSCs) strongly suppresses the acti...

    Authors: Mingyang Shao, Qing Xu, Zhenru Wu, Yuwei Chen, Yuke Shu, Xiaoyue Cao, Menglin Chen, Bo Zhang, Yongjie Zhou, Rong Yao, Yujun Shi and Hong Bu

    Citation: Stem Cell Research & Therapy 2020 11:37

    Content type: Research

    Published on:

  44. A growing body of evidence suggests that stem cell-derived exosomal microRNAs (miRNAs) could be a promising cardioprotective therapy in the context of hypoxic conditions. The present study aims to explore how ...

    Authors: Zhuzhi Wen, Zun Mai, Xiaolin Zhu, Tao Wu, Yangxin Chen, Dengfeng Geng and Jingfeng Wang

    Citation: Stem Cell Research & Therapy 2020 11:36

    Content type: Research

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  45. Adipose-derived stem cell (ASC) expansion under atmospheric oxygen levels (21%) was previously shown to cause increased reactive oxygen species (ROS) accumulation and genetic instability compared to cells cult...

    Authors: Gal Tirza, Inna Solodeev, Meirav Sela, Ilanit Greenberg, Metsada Pasmanik-Chor, Eyal Gur and Nir Shani

    Citation: Stem Cell Research & Therapy 2020 11:35

    Content type: Research

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  46. Vascularization is important for the clinical application of tissue engineered products. Both adipose-derived stem cells (ASCs) and surgical prefabrication can be used to induce angiogenesis in scaffolds. Our ...

    Authors: Tomasz Dębski, Agata Kurzyk, Barbara Ostrowska, Juliusz Wysocki, Jakub Jaroszewicz, Wojciech Święszkowski and Zygmunt Pojda

    Citation: Stem Cell Research & Therapy 2020 11:34

    Content type: Research

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  47. The original article [1] contains an error in Fig. 5 whereby sub-Fig. 5c, d & 5e are mistakenly mixed-up.

    Authors: Rui Zuo, Minghan Liu, Yanqiu Wang, Jie Li, Wenkai Wang, Junlong Wu, Chao Sun, Bin Li, Ziwen Wang, Weiren Lan, Chao Zhang, Chunmeng Shi and Yue Zhou

    Citation: Stem Cell Research & Therapy 2020 11:33

    Content type: Correction

    Published on:

    The original article was published in Stem Cell Research & Therapy 2019 10:30

  48. Extracellular vesicles, especially exosomes, have emerged as key mediators of intercellular communication with the potential to improve cardiac function as part of cell-based therapies. We previously demonstra...

    Authors: Hanbin Chen, Wenzheng Xia and Meng Hou

    Citation: Stem Cell Research & Therapy 2020 11:31

    Content type: Research

    Published on:

  49. Mesenchymal stem cells (MSCs) secrete a cocktail of growth factors and cytokines, which could promote tissue regeneration and wound healing. Therefore, in clinical practice, post-culture MSC supernatant treatm...

    Authors: Honorata Kraskiewicz, Maria Paprocka, Aleksandra Bielawska-Pohl, Agnieszka Krawczenko, Kinga Panek, Judyta Kaczyńska, Agnieszka Szyposzyńska, Mateusz Psurski, Piotr Kuropka and Aleksandra Klimczak

    Citation: Stem Cell Research & Therapy 2020 11:29

    Content type: Research

    Published on:

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