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  1. The advent of next-generation genome engineering tools like CRISPR-Cas9 has transformed the field of gene therapy, rendering targeted treatment for several incurable diseases. Hematopoietic stem and progenitor...

    Authors: Manoj Kumar K. Azhagiri, Prathibha Babu, Vigneshwaran Venkatesan and Saravanabhavan Thangavel

    Citation: Stem Cell Research & Therapy 2021 12:500

    Content type: Review

    Published on:

  2. Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS). MS affects millions of people and causes a great economic and societal burden. There is no cure for MS. We use...

    Authors: Christina Brown, Christina McKee, Sophia Halassy, Suleiman Kojan, Doug L. Feinstein and G. Rasul Chaudhry

    Citation: Stem Cell Research & Therapy 2021 12:499

    Content type: Research

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  3. Cross talk between cancer cells and the immune system is determinant for cancer progression. Emerging evidence demonstrates that GC characteristics such as metastasis, treatment resistance, and disease recurre...

    Authors: Jared Becerril-Rico, Eduardo Alvarado-Ortiz, Mariel E. Toledo-Guzmán, Rosana Pelayo and Elizabeth Ortiz-Sánchez

    Citation: Stem Cell Research & Therapy 2021 12:498

    Content type: Review

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  4. Adipose-derived mesenchymal stem cells (ADSC)-based therapy is an outstanding treatment strategy for ischaemic disease. However, the therapeutic efficacy of this strategy is not ideal due to the poor paracrine...

    Authors: Yanan Tang, Jiayan Li, Weiyi Wang, Bingyi Chen, Jinxing Chen, Zekun Shen, Jiaxuan Hou, Yifan Mei, Shuang Liu, Liwei Zhang, Zongjin Li and Shaoying Lu

    Citation: Stem Cell Research & Therapy 2021 12:497

    Content type: Research

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  5. Fulminant hepatitis is a severe life-threatening clinical condition with rapid progressive loss of liver function. It is characterized by massive activation and infiltration of immune cells into the liver and ...

    Authors: Lijie Pan, Chang Liu, Qiuli Liu, Yanli Li, Cong Du, Xinmei Kang, Shuai Dong, Zhuowei Zhou, Huaxin Chen, Xiaoqi Liang, Jiajie Chu, Yan Xu and Qi Zhang

    Citation: Stem Cell Research & Therapy 2021 12:496

    Content type: Research

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  6. Feline adipose-derived mesenchymal stem cells (ASCs) engage with a variety of immune cells and have been used in several clinical trials for the treatment of inflammatory and immune-dysregulated diseases in ca...

    Authors: Nopmanee Taechangam, Naomi J. Walker and Dori L. Borjesson

    Citation: Stem Cell Research & Therapy 2021 12:495

    Content type: Research

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  7. Authors: Bing-zhou Xue, Wei Xiang, Qing Zhang, Hao-fei Wang, Yu-jie Zhou, Han Tian, Ahmed Abdelmaksou, Jian Xue, Min-xuan Sun, Dong-ye Yi, Nan-xiang Xiong, Xiao-bing Jiang, Hong-yang Zhao and Peng Fu

    Citation: Stem Cell Research & Therapy 2021 12:493

    Content type: Correction

    Published on:

    The original article was published in Stem Cell Research & Therapy 2021 12:394

  8. It is postulated as a general concept of cancer stem cells (CSCs) that they can produce cancer cells overtly and repopulate cancer progenitor cells indefinitely. The CSC niche is part of a specialized cancer m...

    Authors: Kenly Wuputra, Chia-Chen Ku, Kohsuke Kato, Deng-Chyang Wu, Shigeo Saito and Kazunari K. Yokoyama

    Citation: Stem Cell Research & Therapy 2021 12:492

    Content type: Review

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  9. Authors: Yan Li, Jian Zhang, Jihong Shi, Kaituo Liu, Xujie Wang, Yanhui Jia, Ting He, Kuo Shen, Yunchuan Wang, Jiaqi Liu, Wei Zhang, Hongtao Wang, Zhao Zheng and Dahai Hu

    Citation: Stem Cell Research & Therapy 2021 12:490

    Content type: Correction

    Published on:

    The original article was published in Stem Cell Research & Therapy 2021 12:221

  10. Adipose-derived stem cells are frequently used for bone regeneration both in vitro and in vivo. N6-methyladenosine (m6A) is the most abundant post-transcriptional modification on eukaryotic RNAs and plays multifa...

    Authors: Wentian Sun, Yidan Song, Kai Xia, Liyuan Yu, Xinqi Huang, Zhihe Zhao and Jun Liu

    Citation: Stem Cell Research & Therapy 2021 12:489

    Content type: Research

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  11. Human mesenchymal stem cells from dental pulp (hMSC-DP), including dental pulp stem cells from permanent teeth and exfoliated deciduous teeth, possess unique MSC characteristics such as expression of specific ...

    Authors: Lan Ma, Zhiqing Huang, Di Wu, Xiaoxing Kou, Xueli Mao and Songtao Shi

    Citation: Stem Cell Research & Therapy 2021 12:488

    Content type: Research

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  12. Acute lung injury (ALI) is a common lung disorder that affects millions of people every year. The infiltration of inflammatory cells into the lungs and death of the alveolar epithelial cells are key factors to...

    Authors: Junwen Han, Gu Li, Minmin Hou, Julie Ng, Min-Young Kwon, Kevin Xiong, Xiaoliang Liang, Elizabeth Taglauer, Yuanyuan Shi, S. Alex Mitsialis, Stella Kourembanas, Souheil El-Chemaly, James A. Lederer, Ivan O. Rosas, Mark A. Perrella and Xiaoli Liu

    Citation: Stem Cell Research & Therapy 2021 12:487

    Content type: Research

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  13. Alopecia refers to a condition developed by gradual reduction of hair loss by various abnormal causes such as endocrine system, genetic factors, and stress. Stromal vascular fraction (SVF) isolated from the fa...

    Authors: Sun Jong Kim, Myung Jin Kim, Young Jun Lee, Joo Chan Lee, Ji Hyang Kim, Do Ha Kim, Young Hoo Do, Jun Woo Choi, Sung Ill Chung and Byung-Rok Do

    Citation: Stem Cell Research & Therapy 2021 12:486

    Content type: Short report

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  14. Achondroplasia (ACH) is the most common genetic form of dwarfism and belongs to dominant monogenic disorder caused by a gain-of-function point mutation in the transmembrane region of FGFR3. There are no effective...

    Authors: Huan Zou, Mingfeng Guan, Yundong Li, Fang Luo, Wenyuan Wang and Yiren Qin

    Citation: Stem Cell Research & Therapy 2021 12:485

    Content type: Research

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  15. Senile osteoporosis can cause bone fragility and increased risk for fractures and has been one of the most prevalent and severe diseases affecting the elderly population worldwidely. The underlying mechanisms ...

    Authors: Chao Ma, Juan Gao, Jun Liang, Weixiang Dai, Zhenfei Wang, Mengjiao Xia, Tao Chen, Sen Huang, Jian Na, Long Xu, Shiming Feng, Kerong Dai and Guangwang Liu

    Citation: Stem Cell Research & Therapy 2021 12:484

    Content type: Research

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  16. The administration of mesenchymal stem cells (MSCs) remains the most promising approach for cardiac repair after myocardial infarct (MI). However, their poor survival and potential in the ischemic environment ...

    Authors: Zhou Ji, Songsheng Chen, Jin Cui, Weiguang Huang, Rui Zhang, Jianrui Wei and Shaoheng Zhang

    Citation: Stem Cell Research & Therapy 2021 12:483

    Content type: Research

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  17. Human mesenchymal stem cells (hMSCs) therapy has recently been considered a promising treatment for atopic dermatitis (AD) due to their immunomodulation and tissue regeneration ability. In our previous studies...

    Authors: Nari Shin, Namhee Jung, Seung-Eun Lee, Dasom Kong, Nam Gyo Kim, Myung Geun Kook, Hwanhee Park, Soon Won Choi, Seunghee Lee and Kyung-Sun Kang

    Citation: Stem Cell Research & Therapy 2021 12:482

    Content type: Research

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  18. Adipose tissue (AT) has become a source of mesenchymal stromal/stem cells (MSC) for regenerative medicine applications, in particular skeletal disorders. Several enzymatic or mechanical procedures have been pr...

    Authors: Giulia Casari, Elisa Resca, Andrea Giorgini, Olivia Candini, Tiziana Petrachi, Maria Serena Piccinno, Elisabetta Manuela Foppiani, Lucrezia Pacchioni, Marta Starnoni, Massimo Pinelli, Giorgio De Santis, Filippo Selleri, Fabio Catani, Massimo Dominici and Elena Veronesi

    Citation: Stem Cell Research & Therapy 2021 12:481

    Content type: Research

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  19. In human subcutaneous adipose tissue, the superficial fascia distinguishes superficial and deep microenvironments showing extensions called retinacula cutis. The superficial subcutaneous adipose tissue has bee...

    Authors: Leandra Santos Baptista, Isis Côrtes, Bianca Montenegro, Cesar Claudio-da-Silva, Marielle Bouschbacher, Lara Jobeili, Celine Auxenfans and Dominique Sigaudo-Roussel

    Citation: Stem Cell Research & Therapy 2021 12:480

    Content type: Research

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  20. Authors: Ryota Chijimatsu, Satoshi Miwa, Gensuke Okamura, Junya Miyahara, Naohiro Tachibana, Hisatoshi Ishikura, Junya Higuchi, Yuji Maenohara, Shinsaku Tsuji, Shin Sameshima, Kentaro Takagi, Keiu Nakazato, Kohei Kawaguchi, Ryota Yamagami, Hiroshi Inui, Shuji Taketomi…

    Citation: Stem Cell Research & Therapy 2021 12:479

    Content type: Correction

    Published on:

    The original article was published in Stem Cell Research & Therapy 2021 12:405

  21. Sjögren's syndrome (SS) is a chronic, systemic autoimmune disorder characterized by sicca syndrome and/or systemic manifestations. The disease severely affects the health and life of patients, and the treatmen...

    Authors: Boya Li, Yixiao Xing, Yehua Gan, Jing He and Hong Hua

    Citation: Stem Cell Research & Therapy 2021 12:478

    Content type: Research

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  22. Osteoarthritis (OA) is the most common joint degenerative disorder, with little effective therapy to date. Nanofat is a cocktail of cells obtained from fat tissue, which possesses regenerative capacity and has...

    Authors: Zuxiang Chen, Yanzhi Ge, Li Zhou, Ting Li, Bo Yan, Junjie Chen, Jiefeng Huang, Wenxi Du, Shuaijie Lv, Peijian Tong and Letian Shan

    Citation: Stem Cell Research & Therapy 2021 12:477

    Content type: Research

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  23. An extra copy of chromosome 21 in humans can alter cellular phenotypes as well as immune and metabolic systems. Down syndrome is associated with many health-related problems and age-related disorders including...

    Authors: Akiko Tanuma-Takahashi, Momoko Inoue, Kazuhiro Kajiwara, Ryo Takagi, Ayumi Yamaguchi, Osamu Samura, Hidenori Akutsu, Haruhiko Sago, Tohru Kiyono, Aikou Okamoto and Akihiro Umezawa

    Citation: Stem Cell Research & Therapy 2021 12:476

    Content type: Research

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  24. Uterine tissue engineering can provide the opportunity for curing female infertility. Natural scaffold is a good choice to recapitulate the architecture and functionality of the native tissue. In this study, w...

    Authors: Nouri Arezoo, Hajian Mohammad and Monsefi Malihezaman

    Citation: Stem Cell Research & Therapy 2021 12:475

    Content type: Research

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  25. Endometrial stem/progenitor cells have been proved to exist in periodically regenerated female endometrium and can be divided into three categories: endometrial epithelial stem/progenitor cells, CD140b+CD146+ or ...

    Authors: Yue Kong, Yang Shao, Chunxia Ren and Gong Yang

    Citation: Stem Cell Research & Therapy 2021 12:474

    Content type: Review

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  26. Adipose tissue-derived stem cells (ADSCs) autologous transplantation has been a promising strategy for aging-related disorders. However, the relationship between ADSCs senescence and organismal aging has not b...

    Authors: Keya Li, Guiying Shi, Xuepei Lei, Yiying Huang, Xinyue Li, Lin Bai and Chuan Qin

    Citation: Stem Cell Research & Therapy 2021 12:473

    Content type: Research

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  27. Mesenchymal stem cells (MSCs) repair injured tissue in a paracrine manner. To enhance their therapeutic properties, preconditioning with various factors has been researched. We have previously showed that MSCs...

    Authors: Naoki Ishiuchi, Ayumu Nakashima, Shigehiro Doi, Ryo Kanai, Satoshi Maeda, Shinya Takahashi, Masataka Nagao and Takao Masaki

    Citation: Stem Cell Research & Therapy 2021 12:472

    Content type: Research

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  28. Aldehyde dehydrogenase (ALDH) is highly expressed in stem/progenitor cells in various tissues, and cell populations with high ALDH activity (ALDHbr) are associated with tissue repair. However, little is known abo...

    Authors: Hiroshi Takahashi, Taku Nakashima, Takeshi Masuda, Masashi Namba, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada and Noboru Hattori

    Citation: Stem Cell Research & Therapy 2021 12:471

    Content type: Research

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  29. Pulmonary fibrosis (PF) is a chronic, progressive, fibrotic interstitial disease of the lung with poor prognosis and without effective treatment currently. Data from previous coronavirus infections, such as th...

    Authors: Yunyu Zhao, Zhipeng Yan, Ying Liu, Yue Zhang, Jie Shi, Jingtao Li and Fanpu Ji

    Citation: Stem Cell Research & Therapy 2021 12:470

    Content type: Review

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  30. Novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2. The virus causes an exaggerated immune response, resulting in a cytokine storm and acute respiratory dist...

    Authors: Mai Abdelgawad, Nourhan Saied Bakry, Ahmed A. Farghali, Ahmed Abdel-Latif and Ahmed Lotfy

    Citation: Stem Cell Research & Therapy 2021 12:469

    Content type: Review

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  31. To investigate the safety for clinic use and therapeutic effects of basic fibroblast growth factor (bFGF)-overexpressing human umbilical cord-derived mesenchymal stem cells (HUCMSCs) in mice with completely tr...

    Authors: Feifei Huang, Tianyun Gao, Wenqing Wang, Liudi Wang, Yuanyuan Xie, Chenxun Tai, Shuo Liu, Yi Cui and Bin Wang

    Citation: Stem Cell Research & Therapy 2021 12:468

    Content type: Research

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  32. Hypertrophy is a critical process for chondrocyte differentiation and maturation during endochondral ossification, which is responsible for the formation of long bone and postnatal longitudinal growth. Increas...

    Authors: Xuan Wang, Tianwei He, Lei He, Bu Yang, Zhongyu Liu, Mao Pang, Peigen Xie, Liangming Zhang and Limin Rong

    Citation: Stem Cell Research & Therapy 2021 12:467

    Content type: Research

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  33. The results of a previous study verified that umbilical cord mesenchymal stem cells (UCMSCs) have good therapeutic effects for the treatment of HBV-related acute-on-chronic liver failure (ACLF) and liver cirrh...

    Authors: Ka Zhang, Haixia Sun, Huijuan Cao, Yifan Jia, Xin Shu, Hong Cao, Yufeng Zhang and Xiaoan Yang

    Citation: Stem Cell Research & Therapy 2021 12:466

    Content type: Research

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  34. Acute myeloid leukemia (AML) is a serious, life-threatening, and hardly curable hematological malignancy that affects the myeloid cell progenies and challenges patients of all ages but mostly occurs in adults....

    Authors: Faroogh Marofi, Heshu Sulaiman Rahman, Zaid Mahdi Jaber Al-Obaidi, Abduladheem Turki Jalil, Walid Kamal Abdelbasset, Wanich Suksatan, Aleksei Evgenievich Dorofeev, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Ali Hassanzadeh, Behzad Baradaran, Majid Ahmadi, Hossein Saeedi, Safa Tahmasebi and Mostafa Jarahian

    Citation: Stem Cell Research & Therapy 2021 12:465

    Content type: Review

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  35. Retinal regenerative therapies hold great promise for the treatment of inherited retinal degenerations (IRDs). Studies in preclinical lower mammal models of IRDs have suggested visual improvement following ret...

    Authors: Swathi Lingam, Zengping Liu, Binxia Yang, Wendy Wong, Bhav Harshad Parikh, Jun Yi Ong, Debbie Goh, Daniel Soo Lin Wong, Queenie Shu Woon Tan, Gavin S. W. Tan, Graham E. Holder, Kakkad Regha, Veluchamy Amutha Barathi, Walter Hunziker, Gopal Lingam, Xianmin Zeng…

    Citation: Stem Cell Research & Therapy 2021 12:464

    Content type: Research

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  36. The dual inhibitors of receptor interacting protein kinase-1 and -3 (RIP1 and RIP3) play an important role in cell death processes and inflammatory responses. White matter injury (WMI), a leading cause of neur...

    Authors: Chu Zhang, Qian Guan, Hao Shi, Lingsheng Cao, Jing Liu, Zixuan Gao, Wenxi Zhu, Yinxiang Yang, Zuo Luan and Ruiqin Yao

    Citation: Stem Cell Research & Therapy 2021 12:462

    Content type: Research

    Published on:

  37. Pulmonary fibrosis (PF) is a devastating disease characterized by remodeling of lung architecture and abnormal deposition of fibroblasts in parenchymal tissue and ultimately results in respiratory failure and ...

    Authors: Deng-Yuan Li, Ru-Fang Li, Dan-Xiong Sun, Dan-Dan Pu and Yun-Hui Zhang

    Citation: Stem Cell Research & Therapy 2021 12:461

    Content type: Research

    Published on:

  38. Female sex hormone secretion and reproductive ability decrease with ageing. Bone marrow mesenchymal stem cells (BMMSCs) have been postulated to play a key role in treating ovarian ageing.

    Authors: Chuan Tian, Jie He, Yuanyuan An, Zailing Yang, Donghai Yan, Hang Pan, Guanke Lv, Ye Li, Yanying Wang, Yukun Yang, Gaohong Zhu, Zhixu He, Xiangqing Zhu and Xinghua Pan

    Citation: Stem Cell Research & Therapy 2021 12:460

    Content type: Research

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  39. Acute radiation syndrome (ARS) is caused by acute exposure to ionizing radiation that damages multiple organ systems but especially the bone marrow (BM). We have previously shown that human macrophages educate...

    Authors: Matthew H. Forsberg, John A. Kink, Anna S. Thickens, Bryson M. Lewis, Charlie J. Childs, Peiman Hematti and Christian M. Capitini

    Citation: Stem Cell Research & Therapy 2021 12:459

    Content type: Research

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  40. Stem cell therapy has shown great efficacy in many diseases. However, the treatment mechanism is still unclear, which is a big obstacle for promoting clinical research. Therefore, it is particularly important ...

    Authors: Xiaoshuang Zhang, Tong Lei and Hongwu Du

    Citation: Stem Cell Research & Therapy 2021 12:457

    Content type: Review

    Published on:

  41. The efficacy of stem cell therapy for ischemia repair has been limited by low cell retention rate. Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β super family, which h...

    Authors: Chi Zhang, Yinuo Lin, Ke Zhang, Luyang Meng, Xinyang Hu, Jinghai Chen, Wei Zhu and Hong Yu

    Citation: Stem Cell Research & Therapy 2021 12:456

    Content type: Research

    Published on:

  42. Culturing cells as cell spheres results in a tissue-like environment that drives unique cell phenotypes, making it useful for generating cell populations intended for therapeutic use. Unfortunately, common met...

    Authors: Daniel Rodriguez-Granrose, Jeff Zurawski, Will Heaton, Terry Tandeski, Galina Dulatov, Angelica Adrian Highsmith, Mason Conen, Garrett Clark, Amanda Jones, Hannah Loftus, Cameron LeBaron, Erin Scull, Niloo Farhang, Isaac Erickson, Justin Bingham, Paula Decaria…

    Citation: Stem Cell Research & Therapy 2021 12:455

    Content type: Research

    Published on:

  43. As one of the problems and diseases for women before 40 years, premature ovarian failure (POF) could be characterized by amenorrhea, low estrogen levels, infertility, high gonadotropin levels, and lack of matu...

    Authors: Oldouz Shareghi-oskoue, Leili Aghebati-Maleki and Mehdi Yousefi

    Citation: Stem Cell Research & Therapy 2021 12:454

    Content type: Review

    Published on:

  44. Hair follicle stem cells (HFSCs) are among the most widely available resources and most frequently approved model systems used for studying adult stem cells. HFSCs are particularly useful because of their self...

    Authors: Xi-Min Hu, Zhi-Xin Li, Dan-Yi Zhang, Yi-Chao Yang, Shen-ao Fu, Zai-Qiu Zhang, Rong-Hua Yang and Kun Xiong

    Citation: Stem Cell Research & Therapy 2021 12:453

    Content type: Review

    Published on:

  45. Polytrauma is a major clinical problem due to its impact on morbidity and mortality, especially among the younger population. Its pathophysiology is not completely elucidated, and the study of the involvement ...

    Authors: Raúl López, Gerardo J. Martí-Chillón, Juan F. Blanco, Carmen da Casa, Javier González-Robledo, David Pescador, Silvia Preciado, Sandra Muntión and Fermín Sánchez-Guijo

    Citation: Stem Cell Research & Therapy 2021 12:451

    Content type: Research

    Published on:

  46. Mesenchymal stem cells (MSCs) show promising therapeutic potential in treating type 2 diabetes mellitus (T2DM) in clinical studies. Accumulating evidence has suggested that the therapeutic effects of MSCs are ...

    Authors: Qin He, Jia Song, Chen Cui, Jinbang Wang, Huiqing Hu, Xinghong Guo, Mengmeng Yang, Lingshu Wang, Fei Yan, Kai Liang, Zhaojian Liu, Fuqiang Liu, Zheng Sun, Ming Dong, Xinguo Hou and Li Chen

    Citation: Stem Cell Research & Therapy 2021 12:449

    Content type: Research

    Published on:

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