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Stem Cell Research & Therapy


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  1. Content type: Research

    The pharmaceutical agent pentosan polysulfate (PPS) is known to induce proliferation and chondrogenesis of mesenchymal progenitor cells (MPCs) in vitro and in vivo. However, the mechanism(s) of action of PPS i...

    Authors: Jiehua Wu, Susan Shimmon, Sharon Paton, Christopher Daly, Tony Goldschlager, Stan Gronthos, Andrew C. W. Zannettino and Peter Ghosh

    Citation: Stem Cell Research & Therapy 2017 8:278

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  2. Content type: Research

    Oxysterols, oxygenated by-products of cholesterol biosynthesis, play roles in various physiological and pathological systems. However, the effects of oxysterols on periodontal regeneration are unknown. This st...

    Authors: Jin-Sun Lee, EunJi Kim, Seonggu Han, Kyung Lhi Kang and Jung Sun Heo

    Citation: Stem Cell Research & Therapy 2017 8:276

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  3. Content type: Research

    Mesenchymal stem cells (MSCs) are capable of immunomodulation and tissue regeneration, highlighting their potential translational application for treating inflammatory bone disorders. MSC-mediated immunomodula...

    Authors: Tzuhua Lin, Jukka Pajarinen, Akira Nabeshima, Laura Lu, Karthik Nathan, Eemeli Jämsen, Zhenyu Yao and Stuart B. Goodman

    Citation: Stem Cell Research & Therapy 2017 8:277

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  4. Content type: Research

    Mesenchymal stem cells (MSCs) possess intrinsic regeneration capacity as part of the repair process in response to injury, such as fracture or other tissue injury. Bone marrow and adipose tissue are the major ...

    Authors: Liangliang Xu, Yamei Liu, Yuxin Sun, Bin Wang, Yunpu Xiong, Weiping Lin, Qiushi Wei, Haibin Wang, Wei He, Bin Wang and Gang Li

    Citation: Stem Cell Research & Therapy 2017 8:275

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  5. Content type: Review

    Novel therapies are urgently needed to address the rising incidence and prevalence of acute kidney injury (AKI) and chronic kidney disease (CKD). Mesenchymal stem/stromal cells (MSCs) have shown promising resu...

    Authors: Arash Aghajani Nargesi, Lilach O. Lerman and Alfonso Eirin

    Citation: Stem Cell Research & Therapy 2017 8:273

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  6. Content type: Research

    We aimed to evaluate the potential enhancing effect of celastrol on the stemness of human tendon-derived stem cells (hTSCs) in vitro and the underlying molecular mechanisms.

    Authors: Tianyi Wu, Shenghe Liu, Gen Wen, Jia Xu, Yaling Yu and Yimin Chai

    Citation: Stem Cell Research & Therapy 2017 8:274

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  7. Content type: Research

    Human amniotic epithelial cells (hAECs) are attractive candidates for regenerative medical therapy, with the potential to replace deficient cells and improve functional recovery after injury. Previous studies ...

    Authors: Qiuwan Zhang, Shixia Bu, Junyan Sun, Minhua Xu, Xiaofen Yao, Kunyan He and Dongmei Lai

    Citation: Stem Cell Research & Therapy 2017 8:270

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  8. Content type: Research

    Titanium surfaces have been modified by various approaches with the aim of improving the stimulation of osseointegration. Laser beam (Yb-YAG) treatment is a controllable and flexible approach to modifying surf...

    Authors: Tatiana A. B. Bressel, Jana Dara Freires de Queiroz, Susana Margarida Gomes Moreira, Jéssyca T. da Fonseca, Edson A. Filho, Antônio Carlos Guastaldi and Silvia Regina Batistuzzo de Medeiros

    Citation: Stem Cell Research & Therapy 2017 8:269

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  9. Content type: Research

    Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, hold enormous promise for many biomedical applications, such as regenerative medicine, drug testing, and disease...

    Authors: Elvira Parrotta, Maria Teresa De Angelis, Stefania Scalise, Patrizio Candeloro, Gianluca Santamaria, Mariagrazia Paonessa, Maria Laura Coluccio, Gerardo Perozziello, Stefania De Vitis, Antonella Sgura, Elisa Coluzzi, Vincenzo Mollace, Enzo Mario Di Fabrizio and Giovanni Cuda

    Citation: Stem Cell Research & Therapy 2017 8:271

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  10. Content type: Research

    Our study aim was to evaluate the therapeutic efficacy and mechanisms of miR-133-overexpressing mesenchymal stem cells (MSCs) on acute myocardial infarction.

    Authors: Yueqiu Chen, Yunfeng Zhao, Weiqian Chen, Lincen Xie, Zhen-Ao Zhao, Junjie Yang, Yihuan Chen, Wei Lei and Zhenya Shen

    Citation: Stem Cell Research & Therapy 2017 8:268

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  11. Content type: Research

    Intrauterine adhesion (IUA) is a common uterine cavity disease which can be caused by mechanical damage that may eventually lead to infertility and pregnancy abnormalities. Since the effect of therapeutic drug...

    Authors: Huan Yang, Su Wu, Ran Feng, Junjiu Huang, Lixiang Liu, Feng Liu and Yuqing Chen

    Citation: Stem Cell Research & Therapy 2017 8:267

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  12. Content type: Research

    This study aimed to investigate the tolerogenic mechanisms induced by semimature dendritic cells (smDCs) and regulatory dendritic cells (regDCs) after transplantation of hepatocytes differentiated from mouse e...

    Authors: Cheng Zhang, Wenwei Liao, Bing Cai, Furong Liu, Qiong Ke, Xiaofeng Zhu, Xiaoshun He and Anbin Hu

    Citation: Stem Cell Research & Therapy 2017 8:266

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  13. Content type: Research

    Osteoinduction and subsequent bone formation rely on efficient mesenchymal stem cell (MSC) recruitment. It is also known that migration is induced by gradients of growth factors and cytokines. Degradation of Ca2+

    Authors: Rubén Aquino-Martínez, Alcira P. Angelo and Francesc Ventura Pujol

    Citation: Stem Cell Research & Therapy 2017 8:265

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  14. Content type: Research

    Radiation exposure poses a significant threat to public health. Hematopoietic injury is one of the major manifestations of acute radiation sickness. Protection and/or mitigation of hematopoietic stem cells (HS...

    Authors: Pasupathi Sundaramoorthy, Qinhong Wang, Zhihong Zheng, Yiqun Jiao, Benny J. Chen, Phuong L. Doan, Nelson J. Chao and Yubin Kang

    Citation: Stem Cell Research & Therapy 2017 8:263

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  15. Content type: Research

    Effective prevention and treatment of hypertrophic scars (HTSs), a common consequence of deep-partial thickness injury, remain a significant clinical challenge. Previous studies from our group have shown that ...

    Authors: Philippe Foubert, Diana Zafra, Mike Liu, Rohit Rajoria, Damian Gutierrez, Mayer Tenenhaus and John K. Fraser

    Citation: Stem Cell Research & Therapy 2017 8:261

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  16. Content type: Research

    Cell source plays a key role in cell-based cartilage repair and regeneration. Recent efforts in cell coculture have attempted to combine the advantages and negate the drawbacks of the constituent cell types. T...

    Authors: Shu Huang, Xiongbo Song, Tao Li, Jingfang Xiao, Yemiao Chen, Xiaoyuan Gong, Weinan Zeng, Liu Yang and Cheng Chen

    Citation: Stem Cell Research & Therapy 2017 8:264

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  17. Content type: Research

    Adipose tissue-derived mesenchymal stem cells (AT-MSCs) offer potential as a therapeutic option for chronic discogenic low back pain (LBP) because of their immunomodulatory functions and capacity for cartilage...

    Authors: Hemant Kumar, Doo-Hoe Ha, Eun-Jong Lee, Jun Hee Park, Jeong Hyun Shim, Tae-Keun Ahn, Kyoung-Tae Kim, Alexander E. Ropper, Seil Sohn, Chung-Hun Kim, Devang Kashyap Thakor, Soo-Hong Lee and In-Bo Han

    Citation: Stem Cell Research & Therapy 2017 8:262

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  18. Content type: Research

    We aimed to generate a bioengineered multi-lamellar human corneal stroma tissue in vitro by differentiating periodontal ligament stem cells (PDLSCs) towards keratocytes on an aligned silk membrane.

    Authors: Jialin Chen, Wei Zhang, Peyman Kelk, Ludvig J. Backman and Patrik Danielson

    Citation: Stem Cell Research & Therapy 2017 8:260

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  19. Content type: Research

    Administration of bone marrow mononuclear cells (BMMCs) modulates lung inflammation and fibrosis in experimental silicosis. However, no studies have evaluated whether silicosis affects the efficacy of autologo...

    Authors: Helena D’Anunciação de Oliveira, Elga Bernardo Bandeira de Melo, Johnatas Dutra Silva, Jamil Zola Kitoko, Bianca Gutfilen, Thiago Barboza, Sergio Augusto Lopes de Souza, Christina Maeda Takiya, Patricia Rieken Macedo Rocco, Miquéias Lopes-Pacheco and Marcelo Marcos Morales

    Citation: Stem Cell Research & Therapy 2017 8:259

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  20. Content type: Research

    The recruitment of a sufficient number of endogenous mesenchymal stem cells (MSCs) is the first stage of in-situ tissue regeneration. Transforming growth factor beta-3 (TGFβ3) could recruit stem or progenitor ...

    Authors: Moyuan Deng, Tieniu Mei, Tianyong Hou, Keyu Luo, Fei Luo, Aijun Yang, Bo Yu, Hao Pang, Shiwu Dong and Jianzhong Xu

    Citation: Stem Cell Research & Therapy 2017 8:258

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  21. Content type: Research

    Despite advances in neonatal care, bronchopulmonary dysplasia (BPD) remains a significant contributor to infant mortality and morbidity. While human amnion epithelial cells (hAECs) have shown promise in small ...

    Authors: Dandan Zhu, Jean Tan, Amina S. Maleken, Ruth Muljadi, Siow T. Chan, Sin N. Lau, Kirstin Elgass, Bryan Leaw, Joanne Mockler, Daniel Chambers, Kristen T. Leeman, Carla F. Kim, Euan M. Wallace and Rebecca Lim

    Citation: Stem Cell Research & Therapy 2017 8:257

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  22. Content type: Research

    Bi-potential hepatic progenitor cells can give rise to both hepatocytes and cholangiocytes, which is the last phase and critical juncture in terms of sequentially hepatic lineage restriction from any kind of s...

    Authors: Haiyun Pei, Chao Zhai, Huilin Li, Fang Yan, Jinhua Qin, Hongfeng Yuan, Rui Zhang, Shuyong Wang, Wencheng Zhang, Mingyang Chang, Yunfang Wang and Xuetao Pei

    Citation: Stem Cell Research & Therapy 2017 8:252

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  23. Content type: Short report

    Regulation of adipose tissue stem cells (ASCs) and adipogenesis impact the development of excess body fat-related metabolic complications. Animal studies have suggested the presence of distinct subtypes of ASC...

    Authors: Juan R. Acosta, Simon Joost, Kasper Karlsson, Anna Ehrlund, Xidan Li, Myriam Aouadi, Maria Kasper, Peter Arner, Mikael Rydén and Jurga Laurencikiene

    Citation: Stem Cell Research & Therapy 2017 8:250

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