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  1. Stem cell transplantation is emerging as a potential therapy to treat heart diseases. Promising results from early animal studies led to an explosion of small, non-controlled clinical trials that created even ...

    Authors: Samer Arnous, Abdul Mozid, John Martin and Anthony Mathur
    Citation: Stem Cell Research & Therapy 2012 3:2
  2. For many years, the hematopoietic stem cell (HSC) has been well characterized in mice as a cell that can singly reconstitute the whole hematopoietic system of primary recipient animals as well as that of secon...

    Authors: Rhodri Ceredig
    Citation: Stem Cell Research & Therapy 2012 3:1
  3. Distinct stem cell types have been established from embryos and identified in the fetal tissues and umbilical cord blood as well as in specific niches in many adult mammalian tissues and organs such as bone ma...

    Authors: Rubens Camargo Siqueira
    Citation: Stem Cell Research & Therapy 2011 2:50
  4. A clinical trial using human embryonic stem cell (hESC) therapy for an inherited retinal degenerative disease is about to commence. The Advanced Cell Technology (ACT) trial will treat patients with Stargardt's...

    Authors: Reinhold J Medina, Desmond B Archer and Alan W Stitt
    Citation: Stem Cell Research & Therapy 2011 2:47
  5. End-stage renal disease (ESRD) is a major public health problem. Although kidney transplantation is a viable therapeutic option, this therapy is associated with significant limitations, including a shortage of...

    Authors: Tayaramma Thatava, Adam S Armstrong, Josep Genebriera De Lamo, Ramakrishna Edukulla, Yulia Krotova Khan, Toshie Sakuma, Seiga Ohmine, Jamie L Sundsbak, Peter C Harris, Yogish C Kudva and Yasuhiro Ikeda
    Citation: Stem Cell Research & Therapy 2011 2:48
  6. Specialized microenvironments called niches help maintain stem cells in an undifferentiated and self-renewing state. The existence of niches has long been predicted from mammalian studies, but identifying stem...

    Authors: Susan Eliazer and Michael Buszczak
    Citation: Stem Cell Research & Therapy 2011 2:45
  7. The induced pluripotent stem cell (iPSC) technology allows generation of patient-specific pluripotent stem cells, thereby providing a novel cell-therapy platform for severe degenerative diseases. One of the ke...

    Authors: Seiga Ohmine, Allan B Dietz, Michael C Deeds, Katherine A Hartjes, David R Miller, Tayaramma Thatava, Toshie Sakuma, Yogish C Kudva and Yasuhiro Ikeda
    Citation: Stem Cell Research & Therapy 2011 2:46
  8. Mesenchymal stem cells (MSCs) play a central role in mediating endogenous repair of cell and tissue damage. Biologic aging is a universal process that results in changes at the cellular and molecular levels. I...

    Authors: Amitabh C Pandey, Julie A Semon, Deepak Kaushal, Regina P O'Sullivan, Julie Glowacki, Jeffery M Gimble and Bruce A Bunnell
    Citation: Stem Cell Research & Therapy 2011 2:49
  9. Chronic ischemic heart disease is a major cause of patient morbidity and healthcare expenditure. The development of therapies aimed to enhance angiogenesis is targeted for patients with severe ischemic symptom...

    Authors: Peter J Psaltis and Robert D Simari
    Citation: Stem Cell Research & Therapy 2011 2:43
  10. Owing to their potential for differentiation into multiple cell types, multipotent stem cells extracted from many adult tissues are an attractive stem cell resource for the replacement of damaged tissues in re...

    Authors: María Berdasco and Manel Esteller
    Citation: Stem Cell Research & Therapy 2011 2:42
  11. There are many similarities between health issues affecting military and civilian patient populations, with the exception of the relatively small but vital segment of active soldiers who experience high-energy...

    Authors: Gregory T Christopherson and Leon J Nesti
    Citation: Stem Cell Research & Therapy 2011 2:40
  12. Amyloid precursor protein (APP) fascinates cell biologists because it is proteolytically processed to generate multiple peptides, including amyloid-β, which is implicated in Alzheimer's disease. However, a lar...

    Authors: Sanjay W Pimplikar and Kaushik Ghosal
    Citation: Stem Cell Research & Therapy 2011 2:39
  13. Stem cell transplantation is a promising therapeutic strategy for the treatment of stroke. Mesenchymal stem cells (MSCs) are a potential cell source for clinical application because they can be easily obtained...

    Authors: Jung Yeon Lim, Chang Hyun Jeong, Jin Ae Jun, Seong Muk Kim, Chung Heon Ryu, Yun Hou, Wonil Oh, Jong Wook Chang and Sin-Soo Jeun
    Citation: Stem Cell Research & Therapy 2011 2:38
  14. Soluble amyloid precursor protein α (sAPPα) is a proteolyte of APP cleavage by α-secretase. The significance of the cleavage and the physiological role of sAPPα are unknown. A crystal structure of a region of ...

    Authors: Michael P Demars, Amelia Bartholomew, Zuzana Strakova and Orly Lazarov
    Citation: Stem Cell Research & Therapy 2011 2:36
  15. Mesenchymal stem (stromal) cells (MSCs) are rare, multipotent progenitor cells that can be isolated and expanded from bone marrow and other tissues. Strikingly, MSCs modulate the functions of immune cells, inc...

    Authors: Michelle M Duffy, Thomas Ritter, Rhodri Ceredig and Matthew D Griffin
    Citation: Stem Cell Research & Therapy 2011 2:34
  16. A great number of patients around the world experience tooth loss that is attributed to irretrievable damage of the periodontium caused by deep caries, severe periodontal diseases or irreversible trauma. The p...

    Authors: Hidefumi Maeda, Atsushi Tomokiyo, Shinsuke Fujii, Naohisa Wada and Akifumi Akamine
    Citation: Stem Cell Research & Therapy 2011 2:33
  17. We have found that when muscle-derived stem cells (MDSCs) are implanted into a variety of tissues only a small fraction of the donor cells can be found within the regenerated tissues and the vast majority of c...

    Authors: Burhan Gharaibeh, Mitra Lavasani, James H Cummins and Johnny Huard
    Citation: Stem Cell Research & Therapy 2011 2:31
  18. The MRL (Murphy Roths Large) mouse has provided a unique model of adult mammalian regeneration as multiple tissues show this important phenotype. Furthermore, the healing employs a blastema-like structure simi...

    Authors: Larry Matthew Arthur and Ellen Heber-Katz
    Citation: Stem Cell Research & Therapy 2011 2:30
  19. Wong and Reiter have explored the possibility that hair follicle stem cells can give rise to basal cell carcinoma (BCC). They expressed in mice an inducible human BCC-derived oncogenic allele of Smoothened, SmoM2

    Authors: Maya Sieber-Blum
    Citation: Stem Cell Research & Therapy 2011 2:29
  20. Amphibians and zebrafish are able to regenerate lost myocardial tissue without loss of cardiac function; whereas mammals, in response to myocardial injury, develop scar and lose cardiac function. This dichotom...

    Authors: Marc S Penn, Martiza E Mayorga and Feng Dong
    Citation: Stem Cell Research & Therapy 2011 2:24
  21. Multipotent stromal cells (MSCs) are currently in clinical trials for a number of inflammatory diseases. Recent studies have demonstrated the ability of MSCs to attenuate inflammation in rodent models of acute...

    Authors: Svitlana Danchuk, Joni H Ylostalo, Fokhrul Hossain, Randy Sorge, Austin Ramsey, Ryan W Bonvillain, Joseph A Lasky, Bruce A Bunnell, David A Welsh, Darwin J Prockop and Deborah E Sullivan
    Citation: Stem Cell Research & Therapy 2011 2:27
  22. Octamer-binding transcription factor 4 (Oct4) is a master regulator of early mammalian development. Its expression begins from the oocyte stage, becomes restricted to the inner cell mass of the blastocyst and ...

    Authors: Clara Yujing Cheong, Patricia Miang Lon Ng, Rhonda Ponnampalam, Heng-Hang Tsai, Guillaume Bourque and Thomas Lufkin
    Citation: Stem Cell Research & Therapy 2011 2:26
  23. Mesenchymal stem cells (MSCs) are now known to display not only adult stem cell multipotency but also robust anti-inflammatory and regenerative properties. After widespread in vitro and in vivo preclinical testin...

    Authors: Flavio A Carrion and Fernando E Figueroa
    Citation: Stem Cell Research & Therapy 2011 2:23
  24. Owing to wide availability, low cost and avoidance of ethical concerns, umbilical cord blood (UCB) provides an attractive source of stem cells for investigational and therapeutic uses. In this study, we sought...

    Authors: Michael J Berger, Sharon R Minnerath, Sheryl D Adams, Barbara M Tigges, Stacey L Sprague and David H McKenna Jr
    Citation: Stem Cell Research & Therapy 2011 2:19
  25. Unrestricted somatic stem cells (USSC) derived from umbilical cord blood are an attractive alternative to human embryonic stem cells (hESC) for cellular therapy. USSC are capable of forming cells representativ...

    Authors: Caitlin E Filby, Robert Williamson, Peter van Kooy, Alice Pébay, Mirella Dottori, Ngaire J Elwood and Faten Zaibak
    Citation: Stem Cell Research & Therapy 2011 2:16
  26. Growing knowledge on the biology of mesenchymal stem cells (MSCs) has provided new insights into their potential clinical applications, particularly for rheumatologic disorders. Historically, their potential t...

    Authors: Marie Maumus, David Guérit, Karine Toupet, Christian Jorgensen and Danièle Noël
    Citation: Stem Cell Research & Therapy 2011 2:14
  27. Local synthesis of interferon within B16 tumors mediates anti-tumor effects. Based on reports that stem cells are recruited to tumors, and because systemic administration of interferon causes dose-limiting und...

    Authors: Christopher D Krause, Lara S Izotova, Gwangwen Ren, Zeng-Rong Yuan, Yufang Shi, Chiann-Chyi Chen, Yacov Ron and Sidney Pestka
    Citation: Stem Cell Research & Therapy 2011 2:15
  28. A combination of gene and cell therapies has the potential to significantly enhance the therapeutic value of mesenchymal stem cells (MSCs). The development of efficient gene delivery methods is essential if MS...

    Authors: Lisa McGinley, Jill McMahon, Padraig Strappe, Frank Barry, Mary Murphy, Daniel O'Toole and Timothy O'Brien
    Citation: Stem Cell Research & Therapy 2011 2:12
  29. The controlled expression of many genes, including G-protein coupled receptors (GPCRs), is important for delineating gene functions in complex model systems. Binary systems for inducible regulation of transgen...

    Authors: Edward C Hsiao, Trieu D Nguyen, Jennifer K Ng, Mark J Scott, Wei Chun Chang, Hengameh Zahed and Bruce R Conklin
    Citation: Stem Cell Research & Therapy 2011 2:11
  30. The stem cell field in veterinary medicine continues to evolve rapidly both experimentally and clinically. Stem cells are most commonly used in clinical veterinary medicine in therapeutic applications for the ...

    Authors: Lisa A Fortier and Alexander J Travis
    Citation: Stem Cell Research & Therapy 2011 2:9
  31. Pluripotent, human stem cells hold tremendous promise as a source of progenitor and terminally differentiated cells for application in future regenerative therapies. However, such therapies will be dependent u...

    Authors: Yulia Shamis, Kyle J Hewitt, Mark W Carlson, Mariam Margvelashvilli, Shumin Dong, Catherine K Kuo, Laurence Daheron, Christophe Egles and Jonathan A Garlick
    Citation: Stem Cell Research & Therapy 2011 2:10
  32. Mesenchymal progenitor cells, a multipotent adult stem cell population, have the ability to differentiate into cells of connective tissue lineages, including fat, cartilage, bone and muscle, and therefore gene...

    Authors: Janice O'Sullivan, Sinéad D'Arcy, Frank P Barry, JMary Murphy and Cynthia M Coleman
    Citation: Stem Cell Research & Therapy 2011 2:8
  33. Endogenous cell proliferation and gliogenesis have been extensively documented in spinal cord injury, particularly in terms of proliferating oligodendrocyte progenitor cells. Despite the characterization of di...

    Authors: Dana M McTigue and FRezan Sahinkaya
    Citation: Stem Cell Research & Therapy 2011 2:7
  34. The control of differential gene expression is central to all metazoan biology. Haematopoiesis represents one of the best understood developmental systems where multipotent blood stem cells give rise to a rang...

    Authors: Nicola K Wilson, Fernando J Calero-Nieto, Rita Ferreira and Berthold Göttgens
    Citation: Stem Cell Research & Therapy 2011 2:6
  35. Recent development of a synthetic mRNA-based technology for efficient reprogramming to pluripotency and cell fate conversion without any modification to the genome has generated great interest among researcher...

    Authors: Mo Li, Ignacio Sancho-Martinez and Juan Carlos Izpisua Belmonte
    Citation: Stem Cell Research & Therapy 2011 2:5
  36. In the body, tissue homeostasis is established and maintained by resident tissue-specific adult stem cells (aSCs). Through preservation of bidirectional communications with the surrounding niche and integratio...

    Authors: Penny M Gilbert and Helen M Blau
    Citation: Stem Cell Research & Therapy 2011 2:3
  37. Tendon injury is a common problem in athletes, with poor tissue regeneration and a high rate of re-injury. Stem cell therapy is an attractive treatment modality as it may induce tissue regeneration rather than...

    Authors: Ashlee E Watts, Amy E Yeager, Oleg V Kopyov and Alan J Nixon
    Citation: Stem Cell Research & Therapy 2011 2:4

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