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  1. Diabetic patients suffer from impaired wound healing. Mesenchymal stem cell (MSC) therapy represents a promising approach toward improving skin wound healing through the release of soluble growth factors and c...

    Authors: Yongfa Sun, Lili Song, Yong Zhang, Hongjun Wang and Xiao Dong
    Citation: Stem Cell Research & Therapy 2020 11:298
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:82

  2. Skeletal muscle-derived stem cells (SC) have become a promising approach for investigating myogenic differentiation and optimizing tissue regeneration. Muscle regeneration is performed by SC, a self-renewal ce...

    Authors: Mohamed I. Elashry, Mebrie Kinde, Michele C. Klymiuk, Asmaa Eldaey, Sabine Wenisch and Stefan Arnhold
    Citation: Stem Cell Research & Therapy 2022 13:56
    Content type: Research Published on:

  3. Culturing cells as cell spheres results in a tissue-like environment that drives unique cell phenotypes, making it useful for generating cell populations intended for therapeutic use. Unfortunately, common met...

    Authors: Daniel Rodriguez-Granrose, Jeff Zurawski, Will Heaton, Terry Tandeski, Galina Dulatov, Angelica Adrian Highsmith, Mason Conen, Garrett Clark, Amanda Jones, Hannah Loftus, Cameron LeBaron, Erin Scull, Niloo Farhang, Isaac Erickson, Justin Bingham, Paula Decaria…
    Citation: Stem Cell Research & Therapy 2021 12:455
    Content type: Research Published on:

  4. Spinal cord injury (SCI) is a devastating disease that causes extensive damage to oligodendrocytes and neurons leading to demyelination and axonal degeneration. In this study, we co-transplanted cell grafts co...

    Authors: Qian Li, Sumei Liu, Tianqi Zheng, Mo Li, Boling Qi, Liping Zhou, Bochao Liu, Dan Ma, Chao Zhao and Zhiguo Chen
    Citation: Stem Cell Research & Therapy 2024 15:35
    Content type: Research Published on:

  5. The damaged neuronal cells of adult mammalian lack the regenerative ability to replace the neuronal connections. Periodontal ligament stem cells (PDLSCs) are the promising source for neuroregenerative applicat...

    Authors: Fariba Mohebichamkhorami, Roya Fattahi, Zahra Niknam, Morteza Aliashrafi, Sahar Khakpour Naeimi, Samira Gilanchi and Hakimeh Zali
    Citation: Stem Cell Research & Therapy 2022 13:273
    Content type: Review Published on:

  6. Extracellular vesicles (EVs) produced by human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) are currently investigated for their clinical effectiveness towards immune-mediated diseases. The large a...

    Authors: Jonathan Gobin, Gauri Muradia, Jelica Mehic, Carole Westwood, Lauren Couvrette, Andrew Stalker, Stewart Bigelow, Christian C. Luebbert, Frédéric St-Denis Bissonnette, Michael J. W. Johnston, Simon Sauvé, Roger Y. Tam, Lisheng Wang, Michael Rosu-Myles and Jessie R. Lavoie
    Citation: Stem Cell Research & Therapy 2021 12:127
    Content type: Research Published on:

  7. This is the first study evaluating the interactions of human adipose tissue derived stem cells (ADSCs) and human squamous cell carcinoma cells (SCCs), with regard to a prospective cell-based skin regenerative ...

    Authors: Eva Koellensperger, Felix Gramley, Fabian Preisner, Uwe Leimer, Guenter Germann and Verena Dexheimer
    Citation: Stem Cell Research & Therapy 2014 5:65
    Content type: Research Published on:

  8. Skeletal disorders are among the leading debilitating factors affecting millions of people worldwide. The use of stem cells for tissue repair has raised many promises in various medical fields, including skele...

    Authors: Parisa Kangari, Tahereh Talaei-Khozani, Iman Razeghian-Jahromi and Mahboobeh Razmkhah
    Citation: Stem Cell Research & Therapy 2020 11:492
    Content type: Review Published on:

  9. Human induced pluripotent stem cells (hiPSCs) represent a potentially unlimited source of pancreatic endocrine lineage cells. Although insulin-producing β cells derived from hiPSCs have been successfully induc...

    Authors: Xiao-Fei Yang, Shu-Yan Zhou, Ce Wang, Wei Huang, Ning Li, Fei He and Fu-Rong Li
    Citation: Stem Cell Research & Therapy 2020 11:185
    Content type: Research Published on:

  10. Vitamin B3 (nicotinamide) plays important roles in metabolism as well as in SIRT and PARP pathways. It is also recently reported as a novel kinase inhibitor with multiple targets. Nicotinamide promotes pancrea...

    Authors: Yumeng Zhang, Jiaqi Xu, Zhili Ren, Ya Meng, Weiwei Liu, Ligong Lu, Zhou Zhou and Guokai Chen
    Citation: Stem Cell Research & Therapy 2021 12:362
    Content type: Short report Published on:

  11. Small airway infections caused by respiratory viruses are some of the most prevalent causes of illness and death. With the recent worldwide pandemic due to the severe acute respiratory syndrome coronavirus 2 (...

    Authors: Taylor Do, Lilly Synan, Gibran Ali and Heather Gappa-Fahlenkamp
    Citation: Stem Cell Research & Therapy 2022 13:464
    Content type: Review Published on:

  12. Cartilage damage is a common medical issue in clinical practice. Complete cartilage repair remains a significant challenge owing to the inferior quality of regenerative tissue. Safe and non-invasive magnetic t...

    Authors: Jiyuan Yan, Chaoxu Liu, Chang Tu, Ruizhuo Zhang, Xiangyu Tang, Hao Li, Huaixi Wang, Yongzhuang Ma, Yingchi Zhang, Hua Wu and Gaohong Sheng
    Citation: Stem Cell Research & Therapy 2021 12:572
    Content type: Research Published on:

  13. Mesenchymal stem cells (MSCs) have shown promising potential in allograft survival. However, few reports have focused on comparing the immunosuppressive capacity of MSCs from different sources and administered...

    Authors: Huanmin Kang, Jianing Feng, Yingqian Peng, Yingyi Liu, Yalei Yang, Ying Wu, Jian Huang, Ying Jie, Baihua Chen and Yan He
    Citation: Stem Cell Research & Therapy 2023 14:328
    Content type: Research Published on:

  14. Cell-based tissue engineering represents a promising management for meniscus repair and regeneration. The present study aimed to investigate whether the injection of parathyroid hormone (PTH) (1-34) could prom...

    Authors: Wen Zhao, Tong Zou, Hao Cui, Yangou Lv, Dengke Gao, Chenmei Ruan, Xia Zhang and Yihua Zhang
    Citation: Stem Cell Research & Therapy 2020 11:328
    Content type: Research Published on:

  15. The use of mesenchymal stromal cells (MSCs) for research and clinical application is hampered by cellular heterogeneity and replicative senescence. Generation of MSC-like cells from induced pluripotent stem ce...

    Authors: Jonathan Hollmann, Johanna Brecht, Roman Goetzke, Julia Franzen, Anton Selich, Marco Schmidt, Monika Eipel, Alina Ostrowska, Jan Hapala, Eduardo Fernandez-Rebollo, Gerhard Müller-Newen, Michael Rothe, Thomas Eggermann, Martin Zenke and Wolfgang Wagner
    Citation: Stem Cell Research & Therapy 2020 11:105
    Content type: Research Published on:

  16. The main aim of this study is to evaluate potential human stem cells, such as dental pulp stem cells and amniotic fluid stem cells, combined with collagen scaffold to reconstruct critical-size cranial bone def...

    Authors: Tullia Maraldi, Massimo Riccio, Alessandra Pisciotta, Manuela Zavatti, Gianluca Carnevale, Francesca Beretti, Giovanni B La Sala, Antonella Motta and Anto De Pol
    Citation: Stem Cell Research & Therapy 2013 4:53
    Content type: Research Published on:

  17. The administration of mesenchymal stem cells (MSCs) remains the most promising approach for cardiac repair after myocardial infarct (MI). However, their poor survival and potential in the ischemic environment ...

    Authors: Zhou Ji, Songsheng Chen, Jin Cui, Weiguang Huang, Rui Zhang, Jianrui Wei and Shaoheng Zhang
    Citation: Stem Cell Research & Therapy 2021 12:483
    Content type: Research Published on:

  18. Patients with severe burn injury (over 20% of the total body surface area) experience profound hypermetabolism which significantly prolongs wound healing. Adipose-derived stem cells (ASCs) have been proposed a...

    Authors: David M. Burmeister, Grace Chu-Yuan Chu, Tony Chao, Tiffany C. Heard, Belinda I. Gómez, Linda E. Sousse, Shanmugasundaram Natesan and Robert J. Christy
    Citation: Stem Cell Research & Therapy 2021 12:270
    Content type: Research Published on:

  19. In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients’ survival rate. Bone marrow mesenchymal stem cells...

    Authors: Pengyu Zhou, Hao Liu, Ximao Liu, Xiao Ling, Zezhou Xiao, Peng Zhu, Yufeng Zhu, Jun Lu and Shaoyi Zheng
    Citation: Stem Cell Research & Therapy 2021 12:56
    Content type: Research Published on:

  20. Injury of alveolar epithelial cells and capillary endothelial cells is crucial in the pathogenesis of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Mesenchymal stem cells (MSCs) are a promi...

    Authors: Yuling Luo, Shanhui Ge, Qingui Chen, Shan Lin, Wanmei He and Mian Zeng
    Citation: Stem Cell Research & Therapy 2023 14:27
    Content type: Research Published on:

  21. Ulcerative colitis (UC) is a chronic and recurrent disease without satisfactory treatment strategies. Dental pulp stem cell (DPSC) transplantation has been proposed as a potential therapy for UC. This study ai...

    Authors: Ning Li, Yichi Zhang, Narayan Nepal, Guoqing Li, Ningning Yang, Haoyuan Chen, Qiuchi Lin, Xuechun Ji, Sijia Zhang and Shizhu Jin
    Citation: Stem Cell Research & Therapy 2021 12:30
    Content type: Research Published on:

  22. Adipose-derived stem cells (ASCs) have been reported to reduce fibrosis in various tissues. In this study, we investigated the inhibitory role of ASCs on capsule formation by analyzing the histologic, cellular...

    Authors: Bo-Yoon Park, Dirong Wu, Kyoo-Ri Kwon, Mi-Jin Kim, Tae-Gon Kim, Jun-Ho Lee, Do Young Park and Il-Kug Kim
    Citation: Stem Cell Research & Therapy 2023 14:22
    Content type: Research Published on:

  23. Emerging drug-free in vitro activation (IVA) technique enables patients with premature ovarian insufficiency (POI) to restore ovarian function and conceive their own genetic offspring. However, various issues ...

    Authors: Qian Li, Jiahua Zheng, Zhongkang Li, Yanlai Xiao, Mingle Zhang, Wenxin Shi, He Gao, Xianghua Huang and Jingkun Zhang
    Citation: Stem Cell Research & Therapy 2022 13:347
    Content type: Research Published on:

  24. Most castration-resistant prostate cancers (CRPCs) have a luminal phenotype with high androgen receptor (AR) and prostate-specific antigen (PSA) expression. Currently, it is difficult to culture castration-res...

    Authors: Yalan Xu, Jie Mu, Zhixia Zhou, Yu Leng, Yali Yu, Xiuyue Song, Aihua Liu, Hai Zhu, Jing Li and Dong Wang
    Citation: Stem Cell Research & Therapy 2022 13:299
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:522

  25. Retinal regenerative therapies hold great promise for the treatment of inherited retinal degenerations (IRDs). Studies in preclinical lower mammal models of IRDs have suggested visual improvement following ret...

    Authors: Swathi Lingam, Zengping Liu, Binxia Yang, Wendy Wong, Bhav Harshad Parikh, Jun Yi Ong, Debbie Goh, Daniel Soo Lin Wong, Queenie Shu Woon Tan, Gavin S. W. Tan, Graham E. Holder, Kakkad Regha, Veluchamy Amutha Barathi, Walter Hunziker, Gopal Lingam, Xianmin Zeng…
    Citation: Stem Cell Research & Therapy 2021 12:464
    Content type: Research Published on:

  26. The beneficial functions of bone marrow mesenchymal stem cells (BM-MSCs) decline with decreased cell survival, limiting their therapeutic efficacy for myocardial infarction (MI). Irisin, a novel myokine which ...

    Authors: Jingyu Deng, Ning Zhang, Yong Wang, Chao Yang, Yabin Wang, Chao Xin, Jinming Zhao, Zhitao Jin, Feng Cao and Zheng Zhang
    Citation: Stem Cell Research & Therapy 2020 11:228
    Content type: Research Published on:

  27. Diabetic foot ulceration is a serious chronic complication of diabetes mellitus characterized by high disability, mortality, and morbidity. Platelet-rich plasma (PRP) has been widely used for diabetic wound he...

    Authors: Nesrine Ebrahim, Arigue A. Dessouky, Ola Mostafa, Amira Hassouna, Mohamed M. Yousef, Yasmin Seleem, Eman Abd El Aziz M. El Gebaly, Mona M. Allam, Ayman Samir Farid, Bayan A. Saffaf, Dina Sabry, Ahmed Nawar, Ahmed A. Shoulah, Ahmed H. Khalil, Sami F. Abdalla, Mohamed El-Sherbiny…
    Citation: Stem Cell Research & Therapy 2021 12:392
    Content type: Research Published on:

  28. Mesenchymal stem cells (MSCs), including adipose-derived mesenchymal stem cells (ADSCs), have been shown to attenuate organ damage in acute respiratory distress syndrome (ARDS) and sepsis; however, the underly...

    Authors: Yukie Mizuta, Tomohiko Akahoshi, Jie Guo, Shuo Zhang, Sayoko Narahara, Takahito Kawano, Masaharu Murata, Kentaro Tokuda, Masatoshi Eto, Makoto Hashizume and Ken Yamaura
    Citation: Stem Cell Research & Therapy 2020 11:508
    Content type: Research Published on:

  29. Hematopoietic stem cell transplantation (HSCT) is the main treatment for acute radiation sickness, especially after fatal radiation. The determination of HSCT for radiation patients is mainly based on radiatio...

    Authors: Shixiang Zhou, Yaqiong Li, Lexin He, Min Chen, Weihong Li, Ting Xiao, Jian Guan, Zhenhua Qi, Qi Wang, Siyuan Li, Pingkun Zhou and Zhidong Wang
    Citation: Stem Cell Research & Therapy 2022 13:461
    Content type: Research Published on:

  30. Human-induced pluripotent stem cells (hiPSCs) are considered an ideal resource for regenerative medicine because of their ease of access and infinite expansion ability. To satisfy the sizable requirement for c...

    Authors: Ying Hua, Kenji Yoshimochi, Junjun Li, Kazuhiro Takekita, Motoshi Shimotsuma, Lingjun Li, Xiang Qu, Jingbo Zhang, Yoshiki Sawa, Li Liu and Shigeru Miyagawa
    Citation: Stem Cell Research & Therapy 2022 13:223
    Content type: Research Published on:

  31. With the continuous improvement of human technology, the medical field has gradually moved from molecular therapy to cellular therapy. As a safe and effective therapeutic tool, cell therapy has successfully cr...

    Authors: Jingxuan Li, Zewen Wu, Li Zhao, Yang Liu, Yazhen Su, Xueyan Gong, Fancheng Liu and Liyun Zhang
    Citation: Stem Cell Research & Therapy 2023 14:381
    Content type: Review Published on:

  32. One of the most severe complications of the current COVID-19 pandemic is acute respiratory distress syndrome (ARDS). ARDS is caused by increased amounts of pro-inflammatory cytokines, leading to lung damage an...

    Authors: Haggai Kaspi, Jonathan Semo, Nathalie Abramov, Chen Dekel, Stacy Lindborg, Ralph Kern, Chaim Lebovits and Revital Aricha
    Citation: Stem Cell Research & Therapy 2021 12:72
    Content type: Research Published on:

  33. Critical limb ischemia (CLI), the terminal stage of peripheral arterial disease (PAD), is characterized by an extremely high risk of amputation and vascular issues, resulting in severe morbidity and mortality....

    Authors: Zeinab Shirbaghaee, Mohammad Hassani, Saeed Heidari Keshel and Masoud Soleimani
    Citation: Stem Cell Research & Therapy 2022 13:462
    Content type: Review Published on:

  34. Cholestatic liver fibrosis (CLF) is caused by inflammatory destruction of the intrahepatic bile duct and abnormal proliferation of the small bile duct after cholestasis. Activation of the Notch signaling pathw...

    Authors: Yan-nan Xu, Wen Xu, Xu Zhang, Dan-yang Wang, Xin-rui Zheng, Wei Liu, Jia-mei Chen, Gao-feng Chen, Cheng-hai Liu, Ping Liu and Yong-ping Mu
    Citation: Stem Cell Research & Therapy 2023 14:45
    Content type: Research Published on:

  35. Advanced atherosclerotic lesions are characterized by lipid accumulation, inflammation, and defective efferocytosis. An ideal therapy should address all aspects of this multifactorial disease. Ixmyelocel-T the...

    Authors: Kelly J Ledford, Nikki Murphy, Frank Zeigler and Ronnda L Bartel
    Citation: Stem Cell Research & Therapy 2013 4:135
    Content type: Research Published on:

  36. The field of regenerative medicine is approaching translation to clinical practice, and significant safety concerns and knowledge gaps have become clear as clinical practitioners are considering the potential ...

    Authors: John Harding, R Michael Roberts and Oleg Mirochnitchenko
    Citation: Stem Cell Research & Therapy 2013 4:23
    Content type: Review Published on:

  37. Impaction allograft with cement is a common technique used in revision hip surgeries for the last 20 years. However, its clinical results are inconsistent. Recent studies have shown that mesenchymal stem cells...

    Authors: Yannis Reissis, Elena García-Gareta, Michelle Korda, Gordon W Blunn and Jia Hua
    Citation: Stem Cell Research & Therapy 2013 4:139
    Content type: Research Published on:

  38. The increasing number of clinical trials for induced pluripotent stem cell (iPSC)-derived cell therapy products makes the production on clinical grade iPSC more and more relevant and necessary. Cord blood bank...

    Authors: Belén Álvarez-Palomo, Anna Veiga, Angel Raya, Margarita Codinach, Silvia Torrents, Laura Ponce Verdugo, Clara Rodriguez-Aierbe, Leopoldo Cuellar, Raquel Alenda, Cristina Arbona, Dolores Hernández-Maraver, Cristina Fusté and Sergi Querol
    Citation: Stem Cell Research & Therapy 2022 13:408
    Content type: Research Published on:

  39. Myocardial infarction (MI) is a major cause of death worldwide. Although percutaneous coronary intervention and coronary artery bypass grafting can prolong life, cardiac damage persists. In particular, cardiom...

    Authors: Hao Cheng, Shufu Chang, Rende Xu, Lu Chen, Xiaoyue Song, Jian Wu, Juying Qian, Yunzeng Zou and Jianying Ma
    Citation: Stem Cell Research & Therapy 2020 11:224
    Content type: Research Published on:

  40. The ability to expand organ-specific stem/progenitor cells is critical for translational applications, although uncertainties often arise in identifying the lineage of expanded cells. Therefore, superior insig...

    Authors: Kang Cheng, Antonia Follenzi, Manju Surana, Norman Fleischer and Sanjeev Gupta
    Citation: Stem Cell Research & Therapy 2010 1:6
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2015 6:189

  41. The autologous nerve graft, despite its donor site morbidity and unpredictable functional recovery, continues to be the gold standard in peripheral nerve repair. Rodent research studies have shown promising re...

    Authors: Silvia Palombella, Martino Guiotto, Gillian C. Higgins, Laurent L. Applegate, Wassim Raffoul, Mario Cherubino, Andrew Hart, Mathis O. Riehle and Pietro G. di Summa
    Citation: Stem Cell Research & Therapy 2020 11:432
    Content type: Research Published on:

  42. Mammalian lens regeneration holds great potential as a cataract therapy. However, the mechanism of mammalian lens regeneration is unclear, and the methods for optimization remain in question.

    Authors: Xiaomin Liu, Qingjun Zhou, Yusen Huang, Zheng Fan, Haoyun Duan, Menghan Wang, Zongyi Li and Lixin Xie
    Citation: Stem Cell Research & Therapy 2022 13:198
    Content type: Research Published on:

  44. Factors such as poor engraftment, retention, and survival of the transplanted stem cells are deemed to limit their therapeutic efficacy for wound regeneration. Hence, it is necessary to explore these issues in...

    Authors: Qingzha Deng, Sunxing Huang, Jinkun Wen, Yiren Jiao, Xiaohu Su, Guang Shi and Junjiu Huang
    Citation: Stem Cell Research & Therapy 2020 11:143
    Content type: Research Published on:

  45. Studies have shown that stem cells exert their therapeutic effects on acute kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in an endocrine manner, the injection o...

    Authors: Li Xing, Rui Cui, Lei Peng, Jing Ma, Xiao Chen, Ru-Juan Xie and Bing Li
    Citation: Stem Cell Research & Therapy 2014 5:101
    Content type: Research Published on:

  46. Long-QT syndrome type 2 (LQT2) is a common malignant hereditary arrhythmia. Due to the lack of suitable animal and human models, the pathogenesis of LQT2 caused by human ether-a-go-go-related gene (hERG) deficien...

    Authors: Yun Chang, Ya-nan Li, Rui Bai, Fujian Wu, Shuhong Ma, Amina Saleem, Siyao Zhang, Youxu Jiang, Tao Dong, Tianwei Guo, Chengwen Hang, Wen-jing Lu, Hongfeng Jiang and Feng Lan
    Citation: Stem Cell Research & Therapy 2021 12:278
    Content type: Research Published on:

  47. The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide consideration because of their immense potential for immunomodulation and their therapeutic function in tissue regeneration. MS...

    Authors: Ria Margiana, Alexander Markov, Angelina O. Zekiy, Mohammed Ubaid Hamza, Khalid A. Al-Dabbagh, Sura Hasan Al-Zubaidi, Noora M. Hameed, Irshad Ahmad, R. Sivaraman, Hamzah H. Kzar, Moaed E. Al-Gazally, Yasser Fakri Mustafa and Homayoon Siahmansouri
    Citation: Stem Cell Research & Therapy 2022 13:366
    Content type: Review Published on:

  48. Microglia, the brain’s resident immune cells, play vital roles in brain development, and disorders like Alzheimer’s disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these pro...

    Authors: Imdadul Haq, Jason C. Ngo, Nainika Roy, Richard L. Pan, Nadiya Nawsheen, Rebecca Chiu, Ya Zhang, Masashi Fujita, Rajesh K. Soni, Xuebing Wu, David A. Bennett, Vilas Menon, Marta Olah and Falak Sher
    Citation: Stem Cell Research & Therapy 2024 15:104
    Content type: Method Published on:

  49. Currently, no approved stem cell-based therapies for preserving ovarian function during aging. To solve this problem, we developed a long-term treatment for human embryonic stem cell-derived mesenchymal progen...

    Authors: Eun-Young Shin, Suji Jeong, Jeoung Eun Lee, Dong Seok Jeong, Dong Keun Han, Seok-Ho Hong and Dong Ryul Lee
    Citation: Stem Cell Research & Therapy 2024 15:58
    Content type: Research Published on:

  50. Inflammatory bowel disease (IBD) is a global health problem in which gut microbiota dysbiosis plays a pivotal pathogenic role. Mesenchymal stem cells (MSCs) therapy has emerged as a prospective novel tool for ...

    Authors: Airu Liu, Xiaonan Liang, Wenxin Wang, Chen Wang, Jia Song, Jinbo Guo, Donglei Sun, Dong Wang, Mei Song, Jiaming Qian and Xiaolan Zhang
    Citation: Stem Cell Research & Therapy 2023 14:271
    Content type: Research Published on:
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ISSN: 1757-6512