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  1. Older companion dogs naturally develop a dementia-like syndrome with biological, clinical and therapeutic similarities to Alzheimer disease (AD). Given there has been no new safe, clinically effective and wide...

    Authors: Michael Valenzuela, T. Duncan, A. Abey, A. Johnson, C. Boulamatsis, M. A. Dalton, E. Jacobson, L. Brunel, G. Child, D. Simpson, M. Buckland, A. Lowe, J. Siette, F. Westbrook and P. McGreevy
    Citation: Stem Cell Research & Therapy 2022 13:261
    Content type: Research Published on:

  2. Identifying novel regulatory factors and uncovered mechanisms of somatic cell reprogramming will be helpful for basic research and clinical application of induced pluripotent stem cells (iPSCs). Sin3a, a multi...

    Authors: Jiabao Feng, Fugui Zhu, Dan Ye, Qingquan Zhang, Xudong Guo, Changsheng Du and Jiuhong Kang
    Citation: Stem Cell Research & Therapy 2022 13:29
    Content type: Research Published on:

  3. Chondromalacia patellae (CMP), also known as runner’s knee, typically occurs in young patients, which is characterized by anterior knee pain (AKP) that is associated with visible changes in patellar cartilage....

    Authors: Weitao Zheng, Hanluo Li, Kanghong Hu, Liming Li and Mingjian Bei
    Citation: Stem Cell Research & Therapy 2021 12:412
    Content type: Review Published on:

  5. Cell therapy is a key technology to prevent sacrificing normal skin. Although some studies have shown the promise of human epidermal stem cells (EpiSCs), the efficacy, biosafety and quality control of EpiSC th...

    Authors: Xiaohong Zhao, Xue Li, Ying Wang, Yicheng Guo, Yong Huang, Dalun Lv, Mingxing Lei, Shicang Yu, Gaoxing Luo and Rixing Zhan
    Citation: Stem Cell Research & Therapy 2023 14:4
    Content type: Research Published on:

  6. Stem cell therapy is the most promising treatment option for regenerative medicine. Therapeutic effect of different stem cells has been verified in various disease model. Dedifferentiated fat (DFAT) cells, der...

    Authors: Zhuokai Liang, Yufei He, Haojing Tang, Jian Li, Junrong Cai and Yunjun Liao
    Citation: Stem Cell Research & Therapy 2023 14:207
    Content type: Review Published on:

  7. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important curative therapy for adult acute lymphoblastic leukemia (ALL). For patients who lack a human leukocyte antigen (HLA)-matched sibli...

    Authors: Guangyu Sun, Baolin Tang, Kaidi Song, Yue Wu, Meijuan Tu, Xiang Wan, Wen Yao, Liangquan Geng, Ping Qiang and Xiaoyu Zhu
    Citation: Stem Cell Research & Therapy 2022 13:500
    Content type: Research Published on:

  8. Infantile malignant osteopetrosis (IMO) is an autosomal recessive disorder characterized by non-functional osteoclasts and a fatal outcome early in childhood. About 50% of patients have mutations in the TCIRG1 ge...

    Authors: Xiaojie Xian, Roksana Moraghebi, Henrik Löfvall, Anders Fasth, Kim Henriksen, Johan Richter, Niels-Bjarne Woods and Ilana Moscatelli
    Citation: Stem Cell Research & Therapy 2020 11:179
    Content type: Research Published on:

  9. Human umbilical cord mesenchymal stem cells (hUC-MSCs) have been widely used due to their multipotency, a broad range of sources, painless collection, and compliance with standard amplification. Cell sheet tec...

    Authors: Shuang Gao, Yongqiang Jin, Jianlin Ma, Juan Wang, Jing Wang, Zehua Shao, Taibing Fan, Mingkui Zhang and Dehua Chang
    Citation: Stem Cell Research & Therapy 2022 13:252
    Content type: Research Published on:

  10. Radiation therapy often leads to late radiation-induced skin fibrosis (RISF), causing movement impairment and discomfort. We conducted a comprehensive study to assess the effectiveness of metformin and adipose...

    Authors: Hamid Malekzadeh, Yusuf Surucu, Somaiah Chinnapaka, Katherine S. Yang, José A. Arellano, Yasamin Samadi, Michael W. Epperly, Joel S. Greenberger, J. Peter Rubin and Asim Ejaz
    Citation: Stem Cell Research & Therapy 2024 15:13
    Content type: Research Published on:

  11. Tissue engineered and regenerative approaches for treating tendon injuries are challenged by the limited information on the cellular signaling pathways driving tenogenic differentiation of stem cells. Members ...

    Authors: Sophia K. Theodossiou, Jett B. Murray, LeeAnn A. Hold, Jeff M. Courtright, Anne M. Carper and Nathan R. Schiele
    Citation: Stem Cell Research & Therapy 2021 12:88
    Content type: Research Published on:

  12. The aim of this study was to examine the effect of a three-step approach that utilizes the application of adipose tissue-derived mesenchymal stem cells (AD-MSCs), encapsulation, and pulsed focused ultrasound (...

    Authors: Mehdi Razavi, Tanchen Ren, Fengyang Zheng, Arsenii Telichko, Jing Wang, Jeremy J. Dahl, Utkan Demirci and Avnesh S. Thakor
    Citation: Stem Cell Research & Therapy 2020 11:405
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:526

  13. Existing methods for in vitro differentiation of human pluripotent stem cells (hPSCs) into sinoatrial node-like cells (SANLCs) require complex and undefined medium constituents. This might hinder the elucidati...

    Authors: Xiaojie Hou, Shuhong Ma, Wei Fan, Fang Li, Miaomiao Xu, Chao Yang, Feng Liu, Ying Yan, Juyi Wan, Feng Lan and Bin Liao
    Citation: Stem Cell Research & Therapy 2022 13:158
    Content type: Research Published on:

  14. Mobilization failure may occur when the conventional hematopoietic stem cells (HSCs) mobilization agent granulocyte colony-stimulating factor (G-CSF) is used alone, new regimens were developed to improve mobil...

    Authors: Chengxin Luo, Li Wang, Guixian Wu, Xiangtao Huang, Yali Zhang, Yanni Ma, Mingling Xie, Yanni Sun, Yarui Huang, Zhen Huang, Qiuyue Song, Hui Li, Yu Hou, Xi Li, Shuangnian Xu and Jieping Chen
    Citation: Stem Cell Research & Therapy 2021 12:310
    Content type: Research Published on:

  15. Human pluripotent stem cell (hPSC)-derived hepatocyte-like cells (HLCs) can provide a valuable in vitro model for disease modelling and drug development. However, generating HLCs with characteristics comparabl...

    Authors: Faiza Farhan, Manjari Trivedi, Priscilla Di Wu and Wei Cui
    Citation: Stem Cell Research & Therapy 2023 14:314
    Content type: Research Published on:

  16. Hematopoietic stem cells (HSCs) are the common and essential precursors of all blood cells, including immune cells, and they are responsible for the lifelong maintenance and damage repair of blood tissue homeo...

    Authors: Xinyu Tang, Zhenzhen Wang, Jingyi Wang, Siyuan Cui, Ruirong Xu and Yan Wang
    Citation: Stem Cell Research & Therapy 2023 14:73
    Content type: Review Published on:

  17. Umbilical cord mesenchymal stem cells (UCMSCs) have great potential in the treatment of spinal cord injury. However, the specific therapeutic effect and optimal transplantation strategy are still unclear. Ther...

    Authors: Yubao Lu, Wei Zhang, Zhenming Tian, Qian Liang, Chenrui Liu, Yingjie Wu, Liangming Zhang and Limin Rong
    Citation: Stem Cell Research & Therapy 2022 13:441
    Content type: Review Published on:

  19. Atherosclerotic renal artery stenosis (ARAS) is a risk factor for ischemic and hypertensive kidney disease (HKD) for which autologous mesenchymal stem cell (MSC) appears to be a promising therapy. However, MSC...

    Authors: Busra Isik, Roman Thaler, Busra B. Goksu, Sabena M. Conley, Hayder Al-Khafaji, Arjunmohan Mohan, Mohsen Afarideh, Abdelrhman M. Abumoawad, Xiang Y. Zhu, James D. Krier, Ishran M. Saadiq, Hui Tang, Alfonso Eirin, LaTonya J. Hickson, Andre J. van Wijnen, Stephen C. Textor…
    Citation: Stem Cell Research & Therapy 2021 12:240
    Content type: Research Published on:

  20. Kidney organoids derived from human pluripotent stem cells (HiPSCs) hold huge applications for drug screening, disease modeling, and cell transplanting therapy. However, these applications are limited since ki...

    Authors: Kexin Peng, Wanqin Xie, Tingting Wang, Yamei Li, Jean de Dieu Habimana, Obed Boadi Amissah, Jufang Huang, Yong Chen, Bin Ni and Zhiyuan Li
    Citation: Stem Cell Research & Therapy 2023 14:336
    Content type: Research Published on:

  21. Adipose-derived stem cells (ADSCs) have been isolated, expanded, and applied in the treatment of many diseases. ADSCs have also been used to treat injured articular cartilage. However, there is controversy reg...

    Authors: Phuc Van Pham, Khanh Hong-Thien Bui, Dat Quoc Ngo, Ngoc Bich Vu, Nhung Hai Truong, Nhan Lu-Chinh Phan, Dung Minh Le, Triet Dinh Duong, Thanh Duc Nguyen, Vien Tuong Le and Ngoc Kim Phan
    Citation: Stem Cell Research & Therapy 2013 4:91
    Content type: Research Published on:

  22. Allogeneic hepatocyte transplantation is an emerging approach to treat acute liver defects. However, durable engraftment of the transplanted cells remains a daunting task, as they are actively cleared by the r...

    Authors: Nasir Abbas, Kai You, Anteneh Getachew, Feima Wu, Muzammal Hussain, Xinping Huang, Yan Chen, Tingcai Pan and Yinxiong Li
    Citation: Stem Cell Research & Therapy 2024 15:48
    Content type: Research Published on:

  23. Immunomodulation by mesenchymal stromal cells (MSCs) can occur through trophic factor mechanisms, however, intravenously infused MSCs are rapidly cleared from the body yet a potent immunotherapeutic response i...

    Authors: Michael V. Schrodt, Riley M. Behan-Bush, Jesse N. Liszewski, Madeleine E. Humpal-Pash, Lauren K. Boland, Sabrina M. Scroggins, Donna A. Santillan and James A. Ankrum
    Citation: Stem Cell Research & Therapy 2023 14:206
    Content type: Research Published on:

  24. Periodontitis is initiated and sustained by bacteria. However, the mechanism of bacteria induced periodontitis is still unknown. We hypothesized that bacterial components can affect the functions of stem cells...

    Authors: Chenghua Li, Bei Li, Zhiwei Dong, Li Gao, Xiaoning He, Li Liao, Chenghu Hu, Qintao Wang and Yan Jin
    Citation: Stem Cell Research & Therapy 2014 5:67
    Content type: Research Published on:

  25. To repair bone defects, a variety of bone substitution materials have been used, such as ceramics, metals, natural and synthetic polymers, and combinations thereof. In recent decades, a wide range of synthetic...

    Authors: Siyi Wang, Rong Li, Dandan Xia, Xiao Zhao, Yuan Zhu, Ranli Gu, Jungmin Yoon and Yunsong Liu
    Citation: Stem Cell Research & Therapy 2021 12:123
    Content type: Review Published on:

  26. Adipose-derived stem cells (ADSCs) have raised big interest in therapeutic applications in regenerative medicine and appear to fulfill the criteria for a successful cell therapy. Their low immunogenicity and t...

    Authors: Loubna Mazini, Mohamed Ezzoubi and Gabriel Malka
    Citation: Stem Cell Research & Therapy 2021 12:1
    Content type: Review Published on:

  27. Mesenchymal stem cells (MSCs) may be one of candidates for disease-modifying therapy in Parkinsonian diseases. As knowledge regarding the therapeutic properties of MSCs accumulates, some obstacles still remain...

    Authors: Jin Young Shin, Dong-Yeol Kim, Jieun Lee, Yu Jin Shin, Yi Seul Kim and Phil Hyu Lee
    Citation: Stem Cell Research & Therapy 2022 13:483
    Content type: Research Published on:

  28. Unrestricted somatic stem cells (USSC) derived from umbilical cord blood are an attractive alternative to human embryonic stem cells (hESC) for cellular therapy. USSC are capable of forming cells representativ...

    Authors: Caitlin E Filby, Robert Williamson, Peter van Kooy, Alice Pébay, Mirella Dottori, Ngaire J Elwood and Faten Zaibak
    Citation: Stem Cell Research & Therapy 2011 2:16
    Content type: Research Published on:

  29. Although cord blood (CB) offers promise for treatment of patients with high-risk hematological malignancies and immune disorders, the limited numbers of hematopoietic stem cell (HSC)/progenitor cell in a CB un...

    Authors: Huilin Li, Haiyun Pei, Sihan Wang, Bowen Zhang, Zeng Fan, Yiming Liu, Xiaoyan Xie, Zhou Yang, Lei Xu, Yali Jia, Yun Bai, Yi Han, Lin Chen, Lijuan He, Xue Nan, Wen Yue…
    Citation: Stem Cell Research & Therapy 2020 11:358
    Content type: Research Published on:

  30. The basic pathological changes of primary ovarian insufficiency (POI) include ovarian tissue fibrosis and follicular development disorders. The human umbilical cord mesenchymal stem cell (hUMSC) transplantatio...

    Authors: Linlu Cui, Hongchu Bao, Zhongfeng Liu, Xuejing Man, Hongyuan Liu, Yun Hou, Qianqian Luo, Siyuan Wang, Qiang Fu and Hongqin Zhang
    Citation: Stem Cell Research & Therapy 2020 11:386
    Content type: Research Published on:

  32. Graft-contaminating tumor cells correlate with inferior outcome in high-risk neuroblastoma patients undergoing hematopoietic stem cell transplantation and can contribute to relapse. Motivated by the potential ...

    Authors: Franziska Olm, Lena Panse, Josefina H. Dykes, Daniel Bexell, Thomas Laurell and Stefan Scheding
    Citation: Stem Cell Research & Therapy 2021 12:542
    Content type: Research Published on:

  33. As one of the main functional forms of mesenchymal stem cells (MSCs), MSC-derived extracellular vesicles (MSC-EVs) have shown an alternative therapeutic option in experimental models of allergic asthma. Oxygen...

    Authors: Liyang Dong, Ying Wang, Tingting Zheng, Yanan Pu, Yongbin Ma, Xin Qi, Wenzhe Zhang, Fei Xue, Zirui Shan, Jiameng Liu, Xuefeng Wang and Chaoming Mao
    Citation: Stem Cell Research & Therapy 2021 12:4
    Content type: Research Published on:

  34. Mesenchymal stem cells (MSCs) have the capacity to differentiate into multiple lineages including osteogenic and adipogenic lineages. An increasing number of studies have indicated that lineage commitment by M...

    Authors: Asmat Ullah Khan, Rongmei Qu, Tingyu Fan, Jun Ouyang and Jingxing Dai
    Citation: Stem Cell Research & Therapy 2020 11:283
    Content type: Review Published on:

  35. Mesenchymal stem cells (MSCs) can differentiate into diverse cell types under specific conditions. Dysfunction in the osteogenic differentiation of MSCs can result in bone metabolism-related diseases, includin...

    Authors: Hongwei Gao, Hui Dong, Jiachun Zheng, Xufeng Jiang, Mingzhi Gong, Le Hu, Jinshan He and Yongxiang Wang
    Citation: Stem Cell Research & Therapy 2022 13:43
    Content type: Research Published on:

  36. This study assessed the safety and efficacy of intrathecal injection of umbilical cord tissue mesenchymal stem cells (UCT-MSC) in individuals with cerebral palsy (CP). The diffusion tensor imaging (DTI) was pe...

    Authors: Man Amanat, Anahita Majmaa, Morteza Zarrabi, Masoumeh Nouri, Masood Ghahvechi Akbari, Ali Reza Moaiedi, Omid Ghaemi, Fatemeh Zamani, Sharif Najafi, Reza Shervin Badv, Massoud Vosough, Amir Ali Hamidieh, Mona Salehi, Hadi Montazerlotfelahi, Ali Reza Tavasoli, Morteza Heidari…
    Citation: Stem Cell Research & Therapy 2021 12:439
    Content type: Research Published on:

  37. Recently, tRNA-derived fragments (tRFs) have been shown to serve important biological functions. However, the role of tRFs in gastric cancer has not been fully elucidated. This study aimed to identify the tumo...

    Authors: Linwen Zhu, Zhe Li, Xiuchong Yu, Yao Ruan, Yijing Shen, Yongfu Shao, Xinjun Zhang, Guoliang Ye and Junming Guo
    Citation: Stem Cell Research & Therapy 2021 12:418
    Content type: Research Published on:

  38. Retinitis pigmentosa (RP) is an inherited retinal disease that results in photoreceptor degeneration, leading to severe vision loss or blindness. Due to its genetic heterogeneity, developing a new gene therapy...

    Authors: Eric D. Jong, Sabiha Hacibekiroglu, Lily Guo, Evan Sawula, Biao Li, Chengjin Li, Margaret T. Ho, Molly S. Shoichet, Valerie A. Wallace and Andras Nagy
    Citation: Stem Cell Research & Therapy 2023 14:212
    Content type: Research Published on:

  39. BMP9-stimulated DPSCs, SCAPs and PDLSCs are effective candidates for repairing maxillofacial bone defects in tissue engineering, while the most suitable seed cell source among these three hDMSCs and the optima...

    Authors: Yuxin Zhang, Wenping Luo, Liwen Zheng, Jing Hu, Li Nie, Huan Zeng, Xi Tan, Yucan Jiang, Yeming Li, Tianyu Zhao, Zhuohui Yang, Tong-Chuan He and Hongmei Zhang
    Citation: Stem Cell Research & Therapy 2022 13:535
    Content type: Research Published on:

  40. Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and asthma, are one of the most frequent causes of morbidity and mortality in the global. COPD is characterized by progressive loss o...

    Authors: Hossein Abbaszadeh, Farzaneh Ghorbani, Sanaz Abbaspour-Aghdam, Amin Kamrani, Hamed Valizadeh, Mehdi Nadiri, Armin Sadeghi, Karim Shamsasenjan, Farhad Jadidi-Niaragh, Leila Roshangar and Majid Ahmadi
    Citation: Stem Cell Research & Therapy 2022 13:262
    Content type: Review Published on:

  41. Bone morphogenetic protein 2 (BMP2) is a promising chondrogenic growth factor for cartilage tissue-engineering, but it also induces robust endochondral ossification. Human synovial-derived mesenchymal stromal ...

    Authors: Pengcheng Xiao, Zhenglin Zhu, Chengcheng Du, Yongsheng Zeng, Junyi Liao, Qiang Cheng, Hong Chen, Chen Zhao and Wei Huang
    Citation: Stem Cell Research & Therapy 2021 12:132
    Content type: Research Published on:

  42. Renal tubulointerstitial fibrosis (TIF) plays an important role in the progression of chronic kidney disease (CKD) and its pathogenesis involves epithelial-to-mesenchymal transition (EMT) upon renal injury. Re...

    Authors: Mirae Lee, Seok-hyung Kim, Jong Hyun Jhee, Tae Yeon Kim, Hoon Young Choi, Hyung Jong Kim and Hyeong Cheon Park
    Citation: Stem Cell Research & Therapy 2020 11:422
    Content type: Research Published on:

  43. Similar to humans, the horse is a long-lived, athletic species. The use of mesenchymal stromal cells (MSCs) is a relatively new frontier, but has been used with promising results in treating joint diseases, e....

    Authors: Louise Bundgaard, Allan Stensballe, Kirstine Juul Elbæk and Lise Charlotte Berg
    Citation: Stem Cell Research & Therapy 2020 11:187
    Content type: Research Published on:

  44. The fate of hematopoietic stem cells (HSCs) is determined by a complex regulatory network that includes both intrinsic and extrinsic signals. In the past decades, many intrinsic key molecules of HSCs have been...

    Authors: Jing Zhang, Yaozhen Chen, Dandan Yin, Fan Feng, Qunxing An, Zhixin Liu, Ning An, Jinmei Xu, Jing Yi, Shunli Gu, Wen Yin, Yazhou Wang and Xingbin Hu
    Citation: Stem Cell Research & Therapy 2021 12:579
    Content type: Research Published on:

  45. Co-transplantation of bone marrow cells (BMCs) and mesenchymal stem cells (MSCs) is used as a strategy to improve the outcomes of bone marrow transplantation. Tonsil-derived MSCs (TMSCs) are a promising source...

    Authors: Hyun-Ji Lee, Yu-Hee Kim, Da-Won Choi, Kyung-Ah Cho, Joo-Won Park, Sang-Jin Shin, Inho Jo, So-Youn Woo and Kyung-Ha Ryu
    Citation: Stem Cell Research & Therapy 2021 12:329
    Content type: Research Published on:

  46. Loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) underlines much of the pathology of Parkinson’s disease (PD), but the existence of an endogenous neurogenic system that could be target...

    Authors: Theodora Mourtzi, Dimitrios Dimitrakopoulos, Dimitrios Kakogiannis, Charalampos Salodimitris, Konstantinos Botsakis, Danai Kassandra Meri, Maria Anesti, Aggeliki Dimopoulou, Ioannis Charalampopoulos, Achilleas Gravanis, Nikolaos Matsokis, Fevronia Angelatou and Ilias Kazanis
    Citation: Stem Cell Research & Therapy 2021 12:335
    Content type: Research Published on:

  47. Accumulating proofs signify that pleiotropic effects of mesenchymal stromal cells (MSCs) are not allied to their differentiation competencies but rather are mediated mainly by the releases of soluble paracrine...

    Authors: Hadi Yari, Maria V. Mikhailova, Mahsa Mardasi, Mohsen Jafarzadehgharehziaaddin, Somayeh Shahrokh, Lakshmi Thangavelu, Hosein Ahmadi, Navid Shomali, Yoda Yaghoubi, Majid Zamani, Morteza Akbari and Samira Alesaeidi
    Citation: Stem Cell Research & Therapy 2022 13:423
    Content type: Review Published on:

  48. Adipose-derived mesenchymal stem cells (ASCs) therapy is emerging as a novel therapeutic option for the treatment of a variety of diseases including diabetes and diabetic wound healing. Multiple studies indica...

    Authors: Ran An, Yong Zhang, Yu Qiao, Lili Song, Hongjun Wang and Xiao Dong
    Citation: Stem Cell Research & Therapy 2020 11:120
    Content type: Research Published on:

  49. Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. Whether extracellular vesicles are effective in treating IPF and what is the optimal administrative route is not clear....

    Authors: Shengnan Yang, Peipei Liu, Tingting Gao, Dingyun Song, Xinyu Zhao, Yupeng Li, Jun Wu, Liu Wang, Zai Wang, Jie Hao, Chen Wang and Huaping Dai
    Citation: Stem Cell Research & Therapy 2022 13:163
    Content type: Research Published on:

  50. Ever since their discovery, induced pluripotent stem cells (iPSCs) have been extensively differentiated into a large variety of cell types. However, a limited amount of work has been dedicated to differentiati...

    Authors: Alexander Blümke, Erica Ijeoma, Jessica Simon, Rachel Wellington, Medania Purwaningrum, Sergei Doulatov, Elizabeth Leber, Marta Scatena and Cecilia M. Giachelli
    Citation: Stem Cell Research & Therapy 2023 14:319
    Content type: Research Published on:
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