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  1. Continuous cross talk between MSCs and macrophages is integral to acute and chronic inflammation resulting from contaminated polyethylene particles (cPE); however, the effect of this inflammatory microenvironm...

    Authors: Victoria Teissier, Qi Gao, Huaishuang Shen, Jiannan Li, Xueping Li, Elijah Ejun Huang, Junichi Kushioka, Masakazu Toya, Masanori Tsubosaka, Hirohito Hirata, Hossein Vahid Alizadeh, Chima V. Maduka, Christopher H. Contag, Yunzhi Peter Yang, Ning Zhang and Stuart B. Goodman
    Citation: Stem Cell Research & Therapy 2023 14:99
  2. G-quadruplex (G4) motifs are nucleic acid secondary structures observed in mammalian genomes and transcriptomes able to regulate various cellular processes. Several small molecules have been developed so far t...

    Authors: Maria Rosaria Ambrosio, Teresa Migliaccio, Fabiana Napolitano, Sarah Di Somma, Giovanni Maneli, Jussara Amato, Bruno Pagano, Antonio Randazzo, Giuseppe Portella, Pietro Formisano and Anna Maria Malfitano
    Citation: Stem Cell Research & Therapy 2023 14:98
  3. Endogenously released adenine and uracil nucleotides favour the osteogenic commitment of bone marrow-derived mesenchymal stromal cells (BM-MSCs) through the activation of ATP-sensitive P2X7 and UDP-sensitive P2Y6

    Authors: José Bernardo Noronha-Matos, Rui Pinto-Cardoso, Catarina Bessa-Andrês, Maria Teresa Magalhães-Cardoso, Fátima Ferreirinha, Maria Adelina Costa, José Marinhas, Rolando Freitas, Rui Lemos, Adélio Vilaça, António Oliveira, Julie Pelletier, Jean Sévigny and Paulo Correia-de-Sá
    Citation: Stem Cell Research & Therapy 2023 14:97
  4. Constructs currently used to repair or replace congenitally diseased pediatric heart valves lack a viable cell population capable of functional adaptation in situ, necessitating repeated surgical intervention....

    Authors: Shouka Parvin Nejad, Monica Lecce, Bahram Mirani, Nataly Machado Siqueira, Zahra Mirzaei, J. Paul Santerre, John E. Davies and Craig A. Simmons
    Citation: Stem Cell Research & Therapy 2023 14:96
  5. This study reports the incidence of chronic graft versus host disease (GvHD) in allogeneic hematopoietic stem cell transplant (alloHCT) recipients who received SARS-CoV2 vaccination. The overall rates of new a...

    Authors: Dat Ngo, Jason Chen, Jose Tinajero, Ahmed Aribi, Shukaib Arslan, Guido Marcucci, Ryotaro Nakamura, Monzr M. Al Malki, Stephen J. Forman, Sanjeet Dadwal and Haris Ali
    Citation: Stem Cell Research & Therapy 2023 14:95
  6. High-throughput pharmaco-toxicological testing frequently relies on the use of established liver-derived cell lines, such as HepG2 cells. However, these cells often display limited hepatic phenotype and featur...

    Authors: Guillem Garcia-Llorens, Teresa Martínez-Sena, Eugenia Pareja, Laia Tolosa, José V. Castell and Roque Bort
    Citation: Stem Cell Research & Therapy 2023 14:94
  7. Mesenchymal stem cell (MSC) transplantation therapy is highly investigated for the regenerative repair of cartilage defects. Low-intensity pulsed ultrasound (LIPUS) has the potential to promote chondrogenic di...

    Authors: Yiming Chen, Huiyi Yang, Zhaojie Wang, Rongrong Zhu, Liming Cheng and Qian Cheng
    Citation: Stem Cell Research & Therapy 2023 14:93
  8. Although human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) are a promising cell resource for cardiovascular research, these cells exhibit an immature phenotype that hampers their potential ...

    Authors: Jingjun Zhou, Baiping Cui, Xiaochen Wang, Hongkun Wang, Junnan Zheng, Fengfeng Guo, Yaxun Sun, Hangping Fan, Jiaxi Shen, Jun Su, Jue Wang, Haige Zhao, Yiquan Tang, Tingyu Gong, Ning Sun and Ping Liang
    Citation: Stem Cell Research & Therapy 2023 14:92
  9. The success of stem cell therapy for knee osteoarthritis (KOA) in preclinical animal models has accelerated the pace of clinical translation. However, it remains uncertain whether the current scientific eviden...

    Authors: Zhizhong Shang, Pingping Wanyan, Baolin Zhang, Mingchuan Wang and Xin Wang
    Citation: Stem Cell Research & Therapy 2023 14:91
  10. Muscular diseases and injuries are challenging issues in human medicine, resulting in physical disability. The advent of tissue engineering approaches has paved the way for the restoration and regeneration of ...

    Authors: Atieh Rezaei Namjoo, Fateme Nazary Abrbekoh, Sepideh Saghati, Hassan Amini, Mohammad Ali Ebrahimi Saadatlou and Reza Rahbarghazi
    Citation: Stem Cell Research & Therapy 2023 14:90
  11. Mesenchymal stem cells (MSCs) have been proven to prevent and clear corneal scarring and limbal stem cell deficiency. However, using animal-derived serum in a culture medium raises the ethical and regulatory b...

    Authors: Abhishek Sahoo, Mukesh Damala, Jilu Jaffet, Deeksha Prasad, Sayan Basu and Vivek Singh
    Citation: Stem Cell Research & Therapy 2023 14:89
  12. Mesenchymal stem cell (MSC) transplantation is a promising therapeutic approach for noise-induced hearing loss (NIHL). As the indispensable role of apoptosis in MSC transplantation was raised, the benefits of ...

    Authors: Xiaotong Huang, Xiaoxing Kou, Ting Zhan, Guokun Wei, Feinan He, Xueli Mao and Haidi Yang
    Citation: Stem Cell Research & Therapy 2023 14:88
  13. The first human brain organoid protocol was presented in the beginning of the previous decade, and since then, the field witnessed the development of many new brain region-specific models, and subsequent proto...

    Authors: Lance A. Mulder, Josse A. Depla, Adithya Sridhar, Katja Wolthers, Dasja Pajkrt and Renata Vieira de Sá
    Citation: Stem Cell Research & Therapy 2023 14:87
  14. We performed the first autologous oral mucosa-derived epithelial cell sheet transplantation therapy in a patient with refractory postoperative anastomotic stricture in congenital esophageal atresia (CEA) and c...

    Authors: Akihiro Fujino, Yasushi Fuchimoto, Teizaburo Mori, Motohiro Kano, Yohei Yamada, Michinobu Ohno, Yoshiyuki Baba, Nobutaka Isogawa, Katsuhiro Arai, Takako Yoshioka, Makoto Abe, Nobuo Kanai, Ryo Takagi, Masanori Maeda and Akihiro Umezawa
    Citation: Stem Cell Research & Therapy 2023 14:86
  15. Neuroinflammation is closely related to the development of Parkinson's disease (PD). Because of the extensive sources, non-invasive and periodical collection method, human menstrual blood-derived endometrial s...

    Authors: Han Li, Jinghui Wei, Zhigang Zhang, Junyao Li, Yaokai Ma, Ping Zhang and Juntang Lin
    Citation: Stem Cell Research & Therapy 2023 14:85
  16. Stem cell replacement holds the potential for sensorineural hearing loss (SNHL) treatment. However, its translation into clinical practice requires strategies for improving stem cell survival following intraco...

    Authors: Luisa H. Andrade da Silva, Rachel A. Heuer, Christian B. Roque, Tammy L. McGuire, Tomonori Hosoya, Hironobu Kimura, Kouichi Tamura and Akihiro J. Matsuoka
    Citation: Stem Cell Research & Therapy 2023 14:83
  17. Radiation-induced xerostomia and oral mucositis are serious complications of radiation therapy for head and neck cancers. Current treatment options have limited efficacy. Mesenchymal stem cell (MSC) therapy ha...

    Authors: Zirui Guan, Jiaxin Zhang, Nan Jiang, Mingyan Tian, Hongyong Wang and Bing Liang
    Citation: Stem Cell Research & Therapy 2023 14:82
  18. There is an urgent clinical need for targeted strategies aimed at the treatment of bone defects resulting from fractures, infections or tumors. 3D scaffolds represent an alternative to allogeneic MSC transplan...

    Authors: Svetlana Rodimova, Artem Mozherov, Vadim Elagin, Maria Karabut, Ilya Shchechkin, Dmitry Kozlov, Dmitry Krylov, Alena Gavrina, Vladislav Kaplin, Evgenii Epifanov, Nikita Minaev, Ksenia Bardakova, Anna Solovieva, Peter Timashev, Elena Zagaynova and Daria Kuznetsova
    Citation: Stem Cell Research & Therapy 2023 14:81
  19. Parkinson's disease (PD) is a neurodegenerative disease characterized by the degeneration of dopaminergic neurons in the substantia nigra (SN); the etiology and pathological mechanism of the disease are still ...

    Authors: Yi Zhuo, Xuan Li, Zhengwen He and Ming Lu
    Citation: Stem Cell Research & Therapy 2023 14:80
  20. Immune thrombocytopenia (ITP) is an acquired autoimmune disease involving a variety of immune cells and factors. Despite being a benign disease, it is still considered incurable due to its complex pathogenesis...

    Authors: Feifeng Wu, Zhou She, Cuifang Li, Jueyi Mao, Senlin Luo, Xiaoyu Chen, Jidong Tian and Chuan Wen
    Citation: Stem Cell Research & Therapy 2023 14:79
  21. Posterolateral spinal fusion is the standard surgical approach for patients with degenerative disc disease. In our previously published article, we reported a 5-years follow-up of a phase I/II clinical trial i...

    Authors: Victoria Gomez-Ruiz, Juan F. Blanco, Eva M. Villarón, Helena Fidalgo, Miriam López-Parra and Fermín Sánchez-Guijo
    Citation: Stem Cell Research & Therapy 2023 14:78
  22. Dozens of transplants generated from pluripotent stem cells are currently in clinical trials. The creation of patient-specific iPSCs makes personalized therapy possible due to their main advantage of immunotol...

    Authors: Margarita E. Bogomiakova, Elizaveta K. Sekretova, Ksenia S. Anufrieva, Polina O. Khabarova, Anastasia N. Kazakova, Pavel A. Bobrovsky, Tatiana V. Grigoryeva, Artem V. Eremeev, Olga S. Lebedeva, Alexandra N. Bogomazova and Maria A. Lagarkova
    Citation: Stem Cell Research & Therapy 2023 14:77
  23. Human dental pulp-derived mesenchymal stem cells (hDP-MSCs), which include human dental pulp stem cells (hDPSCs) and stem cells from human exfoliated deciduous teeth (SHEDs), are promising cell sources for reg...

    Authors: Pedram Iranmanesh, Amirhossein Vedaei, Sadra Salehi-Mazandarani, Parvaneh Nikpour, Saber Khazaei, Abbasali Khademi, Kerstin M. Galler, Mohammad-Hossein Nekoofar and Paul M. H. Dummer
    Citation: Stem Cell Research & Therapy 2023 14:76
  24. Chemotherapeutic drugs, particularly alkylating cytotoxics such as cyclophosphamide (CTX), play an important role to induce premature ovarian failure (POF). Hormone replacement therapy (HRT) is a widely used t...

    Authors: Guihai Ai, Meng Meng, Jing Guo, Caixia Li, Jihui Zhu, Li Liu, Biting Liu, Wenhan Yang, Xiaowen Shao, Zhongping Cheng and Lian Wang
    Citation: Stem Cell Research & Therapy 2023 14:75
  25. The formation and accumulation of advanced glycation end products (AGEs) have been associated with aging and the development, or worsening, of many degenerative diseases, such as atherosclerosis, chronic kidne...

    Authors: Kuishuai Xu, Liang Zhang, Ning Yu, Zhongkai Ren, Tianrui Wang, Yingze Zhang, Xia Zhao and Tengbo Yu
    Citation: Stem Cell Research & Therapy 2023 14:74
  26. Hematopoietic stem cells (HSCs) are the common and essential precursors of all blood cells, including immune cells, and they are responsible for the lifelong maintenance and damage repair of blood tissue homeo...

    Authors: Xinyu Tang, Zhenzhen Wang, Jingyi Wang, Siyuan Cui, Ruirong Xu and Yan Wang
    Citation: Stem Cell Research & Therapy 2023 14:73
  27. The increasing incidence of osteoporosis in recent years has aroused widespread public concern; however, existing effective treatments are limited. Therefore, new osteoporosis treatment methods, including stem...

    Authors: Xiaoyu He, Yangbin Wang, Zhihua Liu, Yiyong Weng, Shupeng Chen, Qunlong Pan, Yizhong Li, Hanshi Wang, Shu Lin and Haiming Yu
    Citation: Stem Cell Research & Therapy 2023 14:72
  28. Autoimmune/inflammatory diseases affect many people and are an important cause of global incidence and mortality. Mesenchymal stem cells (MSCs) have low immunogenicity, immune regulation, multidifferentiation ...

    Authors: Xueqing Zhu, Dan Ma, Baoqi Yang, Qi An, Jingwen Zhao, Xinnan Gao and Liyun Zhang
    Citation: Stem Cell Research & Therapy 2023 14:71
  29. Adipose tissue-derived stromal vascular fraction (SVF) harbors multipotent cells with potential therapeutic relevance. We developed a method to form adipose spheroids (AS) from the SVF with complex organoid st...

    Authors: Fermín Robledo, Lila González-Hodar, Pablo Tapia, Ana-María Figueroa, Fernando Ezquer and Víctor Cortés
    Citation: Stem Cell Research & Therapy 2023 14:70
  30. There remains much interest in improving cryopreservation techniques for advanced therapy medicinal products (ATMPs). Recently, human platelet lysate (hPL) has emerged as a promising candidate to replace fetal...

    Authors: María Martín-López, Cristina Rosell-Valle, Blanca Arribas-Arribas, Beatriz Fernández-Muñoz, Rosario Jiménez, Sonia Nogueras, Ana Belén García-Delgado, Fernando Campos and Mónica Santos-González
    Citation: Stem Cell Research & Therapy 2023 14:69
  31. Bone defects are among the most common damages in human medicine. Due to limitations and challenges in the area of bone healing, the research field has turned into a hot topic discipline with direct clinical o...

    Authors: Behnaz Banimohamad-Shotorbani, Sonia Fathi Karkan, Reza Rahbarghazi, Ahmad Mehdipour, Seyedhosein Jarolmasjed, Sepideh Saghati and Hajar Shafaei
    Citation: Stem Cell Research & Therapy 2023 14:68
  32. Successful regenerative medicine strategies need the manipulation and control of macrophages’ phenotypic switching. Our previous study indicated that rat and porcine adipose tissue-derived small extracellular ...

    Authors: Jia Dong, Bin Wu and Weidong Tian
    Citation: Stem Cell Research & Therapy 2023 14:67
  33. Early weaning and shorter breastfeeding duration are applied by a proportion of young mothers, especially in the social spheres of poverty-stricken areas. Early childhood is a critical period for intestinal de...

    Authors: Junquan Tian, Yuying Li, Xuetai Bao, Fan Yang, Xiongzhuo Tang, Qian Jiang, Yulong Yin and Kang Yao
    Citation: Stem Cell Research & Therapy 2023 14:65
  34. Detrusor underactivity is a disease that can cause chronic urinary tract infection, urinary tract infection, urinary retention and kidney failure and has no effective treatment in traditional medicine. The pre...

    Authors: Henrique Rodrigues Scherer Coelho, Silvia Cordeiro das Neves, Jovino Nogueira da Silva Menezes, Andréia Conceição Milan Brochado Antoniolli-Silva and Rodrigo Juliano Oliveira
    Citation: Stem Cell Research & Therapy 2023 14:64
  35. Post-translational modifications of proteins are crucial to the regulation of their activity and function. As a newly discovered acylation modification, crotonylation of non-histone proteins remains largely un...

    Authors: Jingran Zhang, Guang Shi, Junjie Pang, Xing Zhu, Qingcai Feng, Jie Na, Wenbin Ma, Dan Liu and Zhou Songyang
    Citation: Stem Cell Research & Therapy 2023 14:63
  36. Extracellular vesicles derived from stem cells (SC-EVs) have been proposed as a novel therapy for ischemic stroke. However, their effects remain incompletely understood. Therefore, we conducted this meta-analy...

    Authors: Jing Zhao, Huiyin Deng, Chengfeng Xun, Chunli Chen, Zhiping Hu, Lite Ge and Zheng Jiang
    Citation: Stem Cell Research & Therapy 2023 14:62
  37. Asherman syndrome (AS), or intrauterine adhesions, is a main cause of infertility in reproductive age women after endometrial injury. Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) are pr...

    Authors: Nahid Mansouri-Kivaj, Abdoreza Nazari, Fereshteh Esfandiari, Faezeh Shekari, Marefat Ghaffari, Mohammad Pakzad and Hossein Baharvand
    Citation: Stem Cell Research & Therapy 2023 14:61
  38. Peripheral arterial disease (PAD) of lower extremities comprises a clinical spectrum that extends from asymptomatic patients to critical limb ischemia (CLI) patients. 10% to 40% of the patients are at the risk...

    Authors: Pawan Kumar Gupta, P. Shivashankar, M. Rajkumar, Subhendu S. Mahapatra, Sanjay C. Desai, Anita Dhar, Vinay Krishna, N. S. Raviraja, Samatha Bhat, Pachaiyappan Viswanathan, Suresh Kannan, Jijy Abraham, Hema Boggarapu, M. S. Manjuprasad and K. Udaykumar
    Citation: Stem Cell Research & Therapy 2023 14:60
  39. Human cerebral organoids (HCOs) offer unprecedented opportunities to study the human brain in vitro, but they also raise important ethical concerns. Here we report the first systematic analysis of scientists’ sta...

    Authors: Andrea Lavazza and Alice Andrea Chinaia
    Citation: Stem Cell Research & Therapy 2023 14:59
  40. Sorafenib is a first-line drug targeting the RTK-MAPK signalling pathway used to treat advanced hepatocellular carcinoma (HCC). However, tumour cells readily develop sorafenib resistance, limiting long-term th...

    Authors: Sining Zhou, Yiming Liu, Qi Zhang, Huikang Xu, Yangxin Fang, Xin Chen, Jiamin Fu, Yin Yuan, Yifei Li, Li Yuan and Charlie Xiang
    Citation: Stem Cell Research & Therapy 2023 14:58
  41. Although the clinical application and transformation of exosomes are still in the exploration stage, the prospects are promising and have a profound impact on the future transformation medicine of exosomes. Ho...

    Authors: Li Han, Zhirong Zhao, Chuanshi He, Jiami Li, Xiangyu Li and Man Lu
    Citation: Stem Cell Research & Therapy 2023 14:57
  42. Recent studies have demonstrated that glioma-associated mesenchymal stem cells (GA-MSCs) are implicated in the regulation of glioma malignant progression. However, the prognostic value of GA-MSCs has not been ...

    Authors: Zesheng Peng, Yuxi Wu, Jiajing Wang, Sujie Gu, Yihao Wang, Bingzhou Xue, Peng Fu and Wei Xiang
    Citation: Stem Cell Research & Therapy 2023 14:56
  43. Progression of senile osteoporosis is associated with deteriorated regenerative potential of bone marrow-derived mesenchymal stem/stromal cells (BMSCs). According to the recent results, the senescent phenotype...

    Authors: Mateusz Sikora, Agnieszka Śmieszek, Ariadna Pielok and Krzysztof Marycz
    Citation: Stem Cell Research & Therapy 2023 14:54
  44. National Eye Institute recently issued a new Strategic Plan outlining priority research areas for the next 5 years. Starting cell source for deriving stem cell lines is as an area with gaps and opportunities for ...

    Authors: Ashley M. Fortress, Kiyoharu J. Miyagishima, Amberlynn A. Reed, Sally Temple, Dennis O. Clegg, Budd A. Tucker, Timothy A. Blenkinsop, George Harb, Thomas N. Greenwell, Tenneille E. Ludwig and Kapil Bharti
    Citation: Stem Cell Research & Therapy 2023 14:53
  45. Endogenous neural stem cells (NSCs) are critical for the remyelination of axons following spinal cord injury (SCI). Cell–cell communication plays a key role in the regulation of the differentiation of NSCs. As...

    Authors: Tianyu Han, Peiwen Song, Zuomeng Wu, Cancan Wang, Yunlei Liu, Wang Ying, Kaixuan Li and Cailiang Shen
    Citation: Stem Cell Research & Therapy 2023 14:52
  46. The composite transplantation of a split-thickness skin graft (STSG) combined with an acellular dermal matrix (ADM) is a promising repair method for full-thickness skin defects. Due to delayed vascularization ...

    Authors: Zhiyong Wang, Hailin Xu, Hao Yang, Yi Zhang, Xiaoyan Wang, Peng Wang, Zhongye Xu, Dongming Lv, Yanchao Rong, Yunxian Dong, Bing Tang, Zhicheng Hu, Wuguo Deng and Jiayuan Zhu
    Citation: Stem Cell Research & Therapy 2023 14:51
  47. Three-dimensional (3D) human brain spheroids are instrumental to study central nervous system (CNS) development and (dys)function. Yet, in current brain spheroid models the limited variety of cell types hamper...

    Authors: Kim M. A. De Kleijn, Wieteke A. Zuure, Kirsten R. Straasheijm, Marijn B. Martens, M. Cristina Avramut, Roman I. Koning and Gerard J. M. Martens
    Citation: Stem Cell Research & Therapy 2023 14:50

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