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  1. It is now well established that factors (free or in extracellular vesicles) secreted by mesenchymal stromal cells (MSC) are important mediators of MSC regenerative actions. Herein we produced the secretome (co...

    Authors: Antonietta Rosa Silini, Andrea Papait, Anna Cargnoni, Elsa Vertua, Pietro Romele, Patrizia Bonassi Signoroni, Marta Magatti, Silvia De Munari, Alice Masserdotti, Anna Pasotti, Sara Rota Nodari, Giorgio Pagani, Mario Bignardi and Ornella Parolini

    Citation: Stem Cell Research & Therapy 2021 12:540

    Content type: Research

    Published on:

  2. Allergic diseases are immune-mediated diseases. Allergies share a common immunopathogenesis, with specific differences according to the specific disease. Mesenchymal stem/stromal cells (MSCs) have been applied...

    Authors: Eun-Young Kim, Hyuk Soon Kim, Ki-Sung Hong, Hyung-Min Chung, Se-Pill Park and Geunwoong Noh

    Citation: Stem Cell Research & Therapy 2021 12:539

    Content type: Review

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  3. The retinal pigment epithelium (RPE) is implicated in the pathophysiology of many retinal degenerative diseases. This cell layer is also an ideal target for cell-based therapies. Several early phase clinical t...

    Authors: John W. Hinkle, Raziyeh Mahmoudzadeh and Ajay E. Kuriyan

    Citation: Stem Cell Research & Therapy 2021 12:538

    Content type: Review

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  4. Although recent studies have investigated the ability of Mesenchymal Stromal Cells (MSCs) to alleviate short-term ovarian damage in animal models of chemotherapy-induced Premature Ovarian Insufficiency (POI), ...

    Authors: Giulia Salvatore, Massimo De Felici, Susanna Dolci, Cosimo Tudisco, Rosella Cicconi, Luisa Campagnolo, Antonella Camaioni and Francesca Gioia Klinger

    Citation: Stem Cell Research & Therapy 2021 12:537

    Content type: Research

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  5. Regulatory T cells (Tregs) play an important role in fine-tuning of immune responses and are pivotal for a successful pregnancy. Recently, the importance of mesenchymal stem cells in regulation of immune respo...

    Authors: Mehdi Aleahmad, Mahmood Bozorgmehr, Shohreh Nikoo, Alireza Ghanavatinejad, Mohammad-Reza Shokri, Samaneh Montazeri, Fazel Shokri and Amir-Hassan Zarnani

    Citation: Stem Cell Research & Therapy 2021 12:536

    Content type: Research

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  6. Tumor necrosis factor (TNF)-α inhibitors represented by Etanercept (a fusion protein containing soluble TNF receptor II (sTNFRII) and the Fc segment of human IgG1) play a pivotal role in Rheumatoid arthritis (...

    Authors: Yingjie Zhao, Xuezhi Yang, Siyu Li, Bingjie Zhang, Susu Li, Xinwei Wang, Yueye Wang, Chengyan Jia, Yan Chang and Wei Wei

    Citation: Stem Cell Research & Therapy 2021 12:535

    Content type: Research

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  7. Mesenchymal stromal cells (MSCs) transplantation showed promising therapeutic results in liver fibrosis. However, efficient cell delivery method is urgently needed and the therapeutic mechanism remains unclear...

    Authors: Hui Yang, Yuanyuan Xie, Tuo Li, Shuo Liu, Sheng Zeng and Bin Wang

    Citation: Stem Cell Research & Therapy 2021 12:534

    Content type: Research

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  8. Chemosenstive non-stem cancer cells (NSCCs) constitute the bulk of tumors and are considered as part of the cancer stem cell (CSC) niche in the tumor microenvironment (TME). Tumor-derived extracellular vesicle...

    Authors: Wei-Min Chung, Ryan D. Molony and Yi-Fen Lee

    Citation: Stem Cell Research & Therapy 2021 12:533

    Content type: Research

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  9. Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disease caused by mutations in the dystrophin gene. Transplantation of myogenic stem cells holds great promise for treating muscular dystrophies. H...

    Authors: Ahmed Elhussieny, Ken’ichiro Nogami, Fusako Sakai-Takemura, Yusuke Maruyama, Natsumi Takemura, Wael Talaat Soliman, Shin’ichi Takeda and Yuko Miyagoe-Suzuki

    Citation: Stem Cell Research & Therapy 2021 12:532

    Content type: Research

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  10. Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. The liver has a crucial role in sepsis and is also a target for sepsis-related injury. Macrophage ...

    Authors: Yujun Xu, Xinghan Liu, Yi Li, Huan Dou, Huaping Liang and Yayi Hou

    Citation: Stem Cell Research & Therapy 2021 12:531

    Content type: Research

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  11. Extracellular vesicles (EVs), which consist of microvesicles and exosomes, are secreted from all cells to transform vital information in the form of lipids, proteins, mRNAs and small RNAs such as microRNAs (mi...

    Authors: Ali Rajool Dezfuly, Azadeh Safaee and Hossein Salehi

    Citation: Stem Cell Research & Therapy 2021 12:530

    Content type: Review

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  12. Current understanding of hematopoiesis is largely derived from mouse models that are physiologically distant from humans. Humanized mice provide the most physiologically relevant small animal model to study hu...

    Authors: Gajendra W. Suryawanshi, Hubert Arokium, Sanggu Kim, Wannisa Khamaikawin, Samantha Lin, Saki Shimizu, Koollawat Chupradit, YooJin Lee, Yiming Xie, Xin Guan, Vasantika Suryawanshi, Angela P. Presson, Dong-Sung An and Irvin S. Y. Chen

    Citation: Stem Cell Research & Therapy 2021 12:528

    Content type: Research

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  13. This study tested whether human induced-pluripotent stem-cell-derived mesenchymal-stem-cells (iPS-MSCs) would offer an additional benefit to the rodent with acute kidney injury (AKI) (ischemia for 1 h followed...

    Authors: Chih-Chao Yang, Pei‐Hsun Sung, Chih-Hung Chen, John Y. Chiang, Pei-Lin Shao, Shun-Cheng Wu and Hon‐Kan Yip

    Citation: Stem Cell Research & Therapy 2021 12:526

    Content type: Research

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  14. Globally, bone fractures are the most common musculoskeletal trauma, and approximately 8–10% of cases that fall into the categories of delayed or non-union healing. To date, there are no efficient pharmacologi...

    Authors: Kai Hang, Li Ying, Jinwu Bai, Yibo Wang, Zhihui Kuang, Deting Xue and Zhijun Pan

    Citation: Stem Cell Research & Therapy 2021 12:525

    Content type: Research

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  15. Previously, we reported a collagenase-based, animal product-free protocol for cultivated oral mucosal epithelial cell sheets for transplantation (COMET). Here, we reported the long-term outcomes of first 2 cli...

    Authors: David Hui-Kang Ma, Yi-Jen Hsueh, Kevin Sheng-Kai Ma, Yueh-Ju Tsai, Shiang-Fu Huang, Hung-Chi Chen, Chi-Chin Sun, Ming-Tse Kuo, An-Shine Chao and Jui-Yang Lai

    Citation: Stem Cell Research & Therapy 2021 12:524

    Content type: Short report

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  16. Integrins play a prominent role in osteogenic differentiation by transmitting both mechanical and chemical signals. Integrin expression is closely associated with tensile stress, which has a positive effect on...

    Authors: Yan Peng, Rongmei Qu, Yanting Feng, Xiaolan Huang, Yuchao Yang, Tingyu Fan, Bing Sun, Asmat Ullah Khan, Shutong Wu, Jingxing Dai and Jun Ouyang

    Citation: Stem Cell Research & Therapy 2021 12:523

    Content type: Research

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  17. Authors: Fangxia Guan, Tuanjie Huang, Xinxin Wang, Qu Xing, Kristyn Gumpper, Peng Li, Jishi Song, Tao Tan, Greta Luyuan Yang, Xingxing Zang, Jiewen Zhang, Yuming Wang, Yunlei Yang, Yashi Liu, Yanting Zhang, Bo Yang…

    Citation: Stem Cell Research & Therapy 2021 12:522

    Content type: Correction

    Published on:

    The original article was published in Stem Cell Research & Therapy 2019 10:352

  18. Recent advances in the identification and application of different stem cell types have offered alternative therapeutic approaches for clinicians. The lack of successful engraftment, migration into the injured...

    Authors: Aysa Rezabakhsh, Emel Sokullu and Reza Rahbarghazi

    Citation: Stem Cell Research & Therapy 2021 12:521

    Content type: Viewpoint

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  19. Quality and Quantity culture media (QQ culture media) was reported to enhance vasculogenesis and angiogenesis function of mononuclear cells (MNCs) from healthy volunteers. In this study, MNCs from chronic limb...

    Authors: Nuttapol Chruewkamlow, Kanin Pruekprasert, Phakawan Phutthakunphithak, Onchira Acharayothin, Tossapol Prapassaro, Kiattisak Hongku, Suteekhanit Hahtapornsawan, Nattawut Puangpunngam, Khamin Chinsakchai, Chumpol Wongwanit, Chanean Ruangsetakit and Nuttawut Sermsathanasawadi

    Citation: Stem Cell Research & Therapy 2021 12:520

    Content type: Research

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  20. Exosomes are considered a substitute for stem cell-based therapy for myocardial infarction (MI). FNDC5, a transmembrane protein located in the cytoplasm, plays a crucial role in inflammation diseases and MI re...

    Authors: Hongjuan Ning, Haixu Chen, Jingyu Deng, Chun Xiao, Moyan Xu, Lina Shan, Chao Yang and Zheng Zhang

    Citation: Stem Cell Research & Therapy 2021 12:519

    Content type: Research

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  21. To investigate the effect of the combination of Wharton's jelly derived mesenchymal stem cells (WJ-MSC) and high frequency repetitive electromagnetic stimulation (rEMS) in the therapy of toxic optic neuropathi...

    Authors: Emin Özmert and Umut Arslan

    Citation: Stem Cell Research & Therapy 2021 12:518

    Content type: Research

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  22. Very small embryonic-like stem cells (VSELs) are a rare population within the ovarian epithelial surface. They contribute to postnatal oogenesis as they have the ability to generate immature oocytes and resist...

    Authors: Nesrine Ebrahim, Hajir A. Al Saihati, Amani Shaman, Arigue A. Dessouky, Ayman Samir Farid, Noha I. Hussien, Ola Mostafa, Yasmin Seleem, Dina Sabry, Ahmed S. Saad, Hanan Tawfeek Emam, Amira Hassouna, Omnia A. M. Badr, Bayan A. Saffaf, Nicholas R. Forsyth and Rabab F. Salim

    Citation: Stem Cell Research & Therapy 2021 12:517

    Content type: Research

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  23. Adipose stromal/stem cells (ASCs) are promising candidates for future clinical applications. ASCs have regenerative capacity, low immunogenicity, and immunomodulatory ability. The success of future cell-based ...

    Authors: Miia Juntunen, Sini Heinonen, Heini Huhtala, Aila Rissanen, Jaakko Kaprio, Kirsi Kuismanen, Kirsi H. Pietiläinen, Susanna Miettinen and Mimmi Patrikoski

    Citation: Stem Cell Research & Therapy 2021 12:516

    Content type: Research

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  24. Peptic ulcer is one of the most common gastrointestinal tract disorders worldwide, associated with challenges such as refractory morbidity, bleeding, interference with use of anticoagulants, and potential side...

    Authors: Mahshid Saleh, Amir Ali Sohrabpour, Mohammad Reza Mehrabi, Iman Seyhoun and Amir Abbas Vaezi

    Citation: Stem Cell Research & Therapy 2021 12:515

    Content type: Review

    Published on:

  25. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) seriously affects patient health. Despite the elusiveness of innate therapeutic effects, mesenchymal stromal cells (MSCs) hold great promise for infla...

    Authors: Hanchao Liu, Xinning Zhu, Xiaohui Cao, Ani Chi, Jian Dai, Zhenqing Wang, Chunhua Deng and Min Zhang

    Citation: Stem Cell Research & Therapy 2021 12:514

    Content type: Research

    Published on:

  26. Bones have a remarkable capacity to heal upon fracture. Yet, in large defects or compromised conditions healing processes become impaired, resulting in delayed or non-union. Current therapeutic approaches ofte...

    Authors: Wai Long Tam, Luís Freitas Mendes, Xike Chen, Raphaëlle Lesage, Inge Van Hoven, Elke Leysen, Greet Kerckhofs, Kathleen Bosmans, Yoke Chin Chai, Akihiro Yamashita, Noriyuki Tsumaki, Liesbet Geris, Scott J. Roberts and Frank P. Luyten

    Citation: Stem Cell Research & Therapy 2021 12:513

    Content type: Research

    Published on:

  27. Considerable experimental and clinical evidences have proved that human umbilical cord mesenchymal stem cells (UC-MSCs) transplantation was powerful in systemic lupus erythematosus (SLE) treatment. MSCs could ...

    Authors: Wang Chun, Jilai Tian and Ying Zhang

    Citation: Stem Cell Research & Therapy 2021 12:512

    Content type: Research

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  28. Phosphoinositide-3 kinase (PI3K)/AKT signaling participates in cellular proliferation, survival and tumorigenesis. The activation of AKT signaling promotes the cellular reprogramming including generation of in...

    Authors: Yoichi Sekita, Yuki Sugiura, Akari Matsumoto, Yuki Kawasaki, Kazuya Akasaka, Ryo Konno, Momoka Shimizu, Toshiaki Ito, Eiji Sugiyama, Terushi Yamazaki, Eriko Kanai, Toshinobu Nakamura, Makoto Suematsu, Fumitoshi Ishino, Yoshio Kodera, Takashi Kohda…

    Citation: Stem Cell Research & Therapy 2021 12:510

    Content type: Research

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  29. Authors: Virginie Neirinckx, Gulistan Agirman, Cécile Coste, Alice Marquet, Valérie Dion, Bernard Rogister, Rachelle Franzen and Sabine Wislet

    Citation: Stem Cell Research & Therapy 2021 12:509

    Content type: Correction

    Published on:

    The original article was published in Stem Cell Research & Therapy 2015 6:211

  30. The c.G6055A (p.G2019S) mutation in leucine-rich repeat kinase 2 (LRRK2) is the most prevalent genetic cause of Parkinson’s disease (PD). CRISPR/Cas9-mediated genome editing by homology-directed repair (HDR) has ...

    Authors: Kuo-Hsuan Chang, Cheng-Yen Huang, Chih-Hsin Ou-Yang, Chang-Han Ho, Han-Yi Lin, Chia-Lang Hsu, You-Tzung Chen, Yu-Chi Chou, Yi-Jing Chen, Ying Chen, Jia-Li Lin, Ji-Kuan Wang, Pei-Wen Lin, Ying-Ru Lin, Miao-Hsia Lin, Chi-Kang Tseng…

    Citation: Stem Cell Research & Therapy 2021 12:508

    Content type: Research

    Published on:

  31. Our previous study proved that Salvia miltiorrhiza could enhance fat graft survival by promoting adipogenesis. However, the effect of salvianolic acid B (Sal-B), the most abundant and bioactive water-soluble comp...

    Authors: Jia-Ming Sun, Chia-Kang Ho, Ya Gao, Chio-Hou Chong, Dan-Ning Zheng, Yi-Fan Zhang and Li Yu

    Citation: Stem Cell Research & Therapy 2021 12:507

    Content type: Research

    Published on:

  32. Mesenchymal stromal cells (MSCs) are a potential therapeutic tool for pulmonary fibrosis. However, ex vivo MSC expansion using serum poses risks of harmful immune responses or unknown pathogen infections in th...

    Authors: Shun Takao, Taku Nakashima, Takeshi Masuda, Masashi Namba, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Shinya Takahashi, Ayumu Nakashima and Noboru Hattori

    Citation: Stem Cell Research & Therapy 2021 12:506

    Content type: Research

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  33. Sympathetic activity plays an important role in the proliferation and differentiation of stem cells, and it changes over time, thereby exerting differential effects on various stem cell types. Aging causes sym...

    Authors: Shiguo Yuan, Sheng Zheng, Kai Zheng, Yanping Gao, Meixiong Chen, Yikai Li and Xiaochun Bai

    Citation: Stem Cell Research & Therapy 2021 12:505

    Content type: Research

    Published on:

  34. Mesenchymal stem cells (MSCs), known from their key role in the regeneration process of tissues, and their abilities to release bioactive factors like extracellular vesicles (EVs) could be considered as a pote...

    Authors: Magdalena M. Kraińska, Natalia Pietrzkowska, Eliza Turlej, Li Zongjin and Krzysztof Marycz

    Citation: Stem Cell Research & Therapy 2021 12:504

    Content type: Review

    Published on:

  35. Approximately one third of patients undergoing core decompression (CD) for early-stage osteonecrosis of the femoral head (ONFH) experience progression of the disease, and subsequently require total hip arthrop...

    Authors: Roberto Alfonso Guzman, Masahiro Maruyama, Seyedsina Moeinzadeh, Elaine Lui, Ning Zhang, Hunter W. Storaci, Kaysie Tam, Elijah Ejun Huang, Takeshi Utsunomiya, Claire Rhee, Qi Gao, Zhenyu Yao, Yunzhi Peter Yang and Stuart B. Goodman

    Citation: Stem Cell Research & Therapy 2021 12:503

    Content type: Research

    Published on:

  36. Although the immunomodulatory properties of mesenchymal stem cells (MSCs) have been highlighted as a new therapy for autoimmune diseases, including rheumatoid arthritis (RA), the disease-specific characteristi...

    Authors: Hyeon-Jeong Lee, Won-Jae Lee, Sun-Chul Hwang, Yongho Choe, Saetbyul Kim, Eunyeong Bok, Sangyeob Lee, Seung-Joon Kim, Hyun-Ok Kim, Sun-A Ock, Hae-Sook Noh, Gyu-Jin Rho, Sang-Il Lee and Sung-Lim Lee

    Citation: Stem Cell Research & Therapy 2021 12:502

    Content type: Research

    Published on:

  37. Hyperpigmentation of skin is caused by an imbalance between the melanosome/melanin synthesis in melanocytes and the melanosome/melanin degradation in keratinocytes. Although studies showed that stem cells play...

    Authors: Xiao-Yu Wang, Xiao-Hui Guan, Zhen-Ping Yu, Jie Wu, Qi-Ming Huang, Ke-Yu Deng and Hong-Bo Xin

    Citation: Stem Cell Research & Therapy 2021 12:501

    Content type: Research

    Published on:

  38. The advent of next-generation genome engineering tools like CRISPR-Cas9 has transformed the field of gene therapy, rendering targeted treatment for several incurable diseases. Hematopoietic stem and progenitor...

    Authors: Manoj Kumar K. Azhagiri, Prathibha Babu, Vigneshwaran Venkatesan and Saravanabhavan Thangavel

    Citation: Stem Cell Research & Therapy 2021 12:500

    Content type: Review

    Published on:

  39. Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS). MS affects millions of people and causes a great economic and societal burden. There is no cure for MS. We use...

    Authors: Christina Brown, Christina McKee, Sophia Halassy, Suleiman Kojan, Doug L. Feinstein and G. Rasul Chaudhry

    Citation: Stem Cell Research & Therapy 2021 12:499

    Content type: Research

    Published on:

  40. Cross talk between cancer cells and the immune system is determinant for cancer progression. Emerging evidence demonstrates that GC characteristics such as metastasis, treatment resistance, and disease recurre...

    Authors: Jared Becerril-Rico, Eduardo Alvarado-Ortiz, Mariel E. Toledo-Guzmán, Rosana Pelayo and Elizabeth Ortiz-Sánchez

    Citation: Stem Cell Research & Therapy 2021 12:498

    Content type: Review

    Published on:

  41. Adipose-derived mesenchymal stem cells (ADSC)-based therapy is an outstanding treatment strategy for ischaemic disease. However, the therapeutic efficacy of this strategy is not ideal due to the poor paracrine...

    Authors: Yanan Tang, Jiayan Li, Weiyi Wang, Bingyi Chen, Jinxing Chen, Zekun Shen, Jiaxuan Hou, Yifan Mei, Shuang Liu, Liwei Zhang, Zongjin Li and Shaoying Lu

    Citation: Stem Cell Research & Therapy 2021 12:497

    Content type: Research

    Published on:

  42. Fulminant hepatitis is a severe life-threatening clinical condition with rapid progressive loss of liver function. It is characterized by massive activation and infiltration of immune cells into the liver and ...

    Authors: Lijie Pan, Chang Liu, Qiuli Liu, Yanli Li, Cong Du, Xinmei Kang, Shuai Dong, Zhuowei Zhou, Huaxin Chen, Xiaoqi Liang, Jiajie Chu, Yan Xu and Qi Zhang

    Citation: Stem Cell Research & Therapy 2021 12:496

    Content type: Research

    Published on:

  43. Feline adipose-derived mesenchymal stem cells (ASCs) engage with a variety of immune cells and have been used in several clinical trials for the treatment of inflammatory and immune-dysregulated diseases in ca...

    Authors: Nopmanee Taechangam, Naomi J. Walker and Dori L. Borjesson

    Citation: Stem Cell Research & Therapy 2021 12:495

    Content type: Research

    Published on:

  44. Authors: Bing-zhou Xue, Wei Xiang, Qing Zhang, Hao-fei Wang, Yu-jie Zhou, Han Tian, Ahmed Abdelmaksou, Jian Xue, Min-xuan Sun, Dong-ye Yi, Nan-xiang Xiong, Xiao-bing Jiang, Hong-yang Zhao and Peng Fu

    Citation: Stem Cell Research & Therapy 2021 12:493

    Content type: Correction

    Published on:

    The original article was published in Stem Cell Research & Therapy 2021 12:394

  45. It is postulated as a general concept of cancer stem cells (CSCs) that they can produce cancer cells overtly and repopulate cancer progenitor cells indefinitely. The CSC niche is part of a specialized cancer m...

    Authors: Kenly Wuputra, Chia-Chen Ku, Kohsuke Kato, Deng-Chyang Wu, Shigeo Saito and Kazunari K. Yokoyama

    Citation: Stem Cell Research & Therapy 2021 12:492

    Content type: Review

    Published on:

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