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  1. Stem cell therapies have been widely investigated for their healing effects. However, the translation of these therapies has been hampered by the requirement to deliver live allogeneic or autologous cells dire...

    Authors: Parinaz Ahangar, Stuart J. Mills, Louise E. Smith, Xanthe L. Strudwick, Anthony E. Ting, Bart Vaes and Allison J. Cowin

    Citation: Stem Cell Research & Therapy 2020 11:299

    Content type: Research

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  2. Diabetic patients suffer from impaired wound healing. Mesenchymal stem cell (MSC) therapy represents a promising approach toward improving skin wound healing through the release of soluble growth factors and c...

    Authors: Yongfa Sun, Lili Song, Yong Zhang, Hongjun Wang and Xiao Dong

    Citation: Stem Cell Research & Therapy 2020 11:298

    Content type: Research

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  3. Systemic transplantation of stem cells from human exfoliated deciduous teeth (SHED) recovers bone loss in animal models of osteoporosis; however, the mechanisms underlying this remain unclear. Here, we hypothe...

    Authors: Soichiro Sonoda, Sara Murata, Kento Nishida, Hiroki Kato, Norihisa Uehara, Yukari N. Kyumoto, Haruyoshi Yamaza, Ichiro Takahashi, Toshio Kukita and Takayoshi Yamaza

    Citation: Stem Cell Research & Therapy 2020 11:296

    Content type: Research

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  4. The oral cavity is a complex environment in which periodontal tissue is constantly stimulated by external microorganisms and mechanical forces. Proper mechanical force helps maintain periodontal tissue homeost...

    Authors: Pei-ying Lv, Peng-fei Gao, Guang-jie Tian, Yan-yan Yang, Fei-fei Mo, Zi-hui Wang, Lu Sun, Ming-jie Kuang and Yong-lan Wang

    Citation: Stem Cell Research & Therapy 2020 11:295

    Content type: Research

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  5. Acute respiratory distress syndrome virus-2 (SARS-CoV-2) responsible for coronavirus disease 2019 (COVID-19) infection, which causes global public health emergencies, has sped widely for more than 5 months and...

    Authors: Hongbing Peng, Tiefeng Gong, Xiaoying Huang, Xun Sun, Hong Luo, Weizhong Wang, Junbiao Luo, Baowei Luo, Yanhui Chen, Xingxing Wang, Haifeng Long, Hua Mei, Chuang Li, Yanni Dai and Honghui Li

    Citation: Stem Cell Research & Therapy 2020 11:291

    Content type: Short report

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  6. Before starting gonadotoxic therapies, cryopreservation of mature sperm has been proposed worldwide as a method for male fertility preservation and for enabling the conception of a healthy baby with assisted r...

    Authors: Chunfeng Qian, Qingxia Meng, Jiafeng Lu, Liya Zhang, Hong Li and Boxian Huang

    Citation: Stem Cell Research & Therapy 2020 11:290

    Content type: Research

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  7. Regeneration of articular cartilage poses a tremendous challenge due to its limited self-repair capability and inflammation at the damaged site. To generate the desired structures that mimic the structure of n...

    Authors: Negin Asgari, Fatemeh Bagheri, Mohamadreza Baghaban Eslaminejad, Mohammad Hossein Ghanian, Forogh Azam Sayahpour and Amir Mohammad Ghafari

    Citation: Stem Cell Research & Therapy 2020 11:289

    Content type: Research

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  8. β-Thalassaemia is a clinically common cause of hereditary haemolytic anaemia stemming from mutations in important functional regions of the β-globin gene. The rapid development of gene editing technology and i...

    Authors: Yexing Xian, Yingjun Xie, Bing Song, Zhanhui Ou, Shuming Ouyang, Yuhuan Xie, Yi Yang, Zeyu Xiong, Haoxian Li and Xiaofang Sun

    Citation: Stem Cell Research & Therapy 2020 11:288

    Content type: Research

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  9. Avascular necrosis of the femoral head (ANFH) is a severely disabling disease of the hip. Several clinical trials have shown promising outcomes on the use of mesenchymal stem cells for the treatment of ANFH, b...

    Authors: Mengyuan Li, Yuanchen Ma, Guangtao Fu, Ruiying Zhang, Qingtian Li, Zhantao Deng, Minghao Zheng and Qiujian Zheng

    Citation: Stem Cell Research & Therapy 2020 11:287

    Content type: Research

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  10. Stress urinary incontinence (SUI) is a common and bothersome condition. Invasive surgery will always be considered after conservative treatment fails, but the rates of postoperative complications and long-term...

    Authors: Hanke Zhang, Jiayu Huang, Jiaying Liu, Yanhui Li and Ying Gao

    Citation: Stem Cell Research & Therapy 2020 11:286

    Content type: Research

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  11. Biological pacemakers derived from pluripotent stem cell (PSC) have been considered as a potential therapeutic surrogate for sick sinus syndrome. So it is essential to develop highly efficient strategies for e...

    Authors: Feng Liu, Yibing Fang, Xiaojie Hou, Ying Yan, Haiying Xiao, Dongchuan Zuo, Jing Wen, Linli Wang, Zhichao Zhou, Xitong Dang, Rui Zhou and Bin Liao

    Citation: Stem Cell Research & Therapy 2020 11:284

    Content type: Research

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  12. Mesenchymal stem cells (MSCs) have the capacity to differentiate into multiple lineages including osteogenic and adipogenic lineages. An increasing number of studies have indicated that lineage commitment by M...

    Authors: Asmat Ullah Khan, Rongmei Qu, Tingyu Fan, Jun Ouyang and Jingxing Dai

    Citation: Stem Cell Research & Therapy 2020 11:283

    Content type: Review

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  13. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Younghee Ju, Jun Sung Park, Daejeong Kim, Bumsoo Kim, Jeong Ho Lee, Yoonkey Nam, Han-Wook Yoo, Beom Hee Lee and Yong-Mahn Han

    Citation: Stem Cell Research & Therapy 2020 11:282

    Content type: Correction

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    The original article was published in Stem Cell Research & Therapy 2020 11:209

  14. In addition to their multilineage potential, mesenchymal stem cells (MSCs) have a broad range of functions from tissue regeneration to immunomodulation. MSCs have the ability to modulate the immune response an...

    Authors: Ghada Beldi, Maryam Khosravi, Mohamed Essameldin Abdelgawad, Benoît L. Salomon, Georges Uzan, Houda Haouas and Sina Naserian

    Citation: Stem Cell Research & Therapy 2020 11:281

    Content type: Research

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  15. Human dental pulp stem cells (DPSCs) are a readily accessible and promising cell source for regenerative medicine. We recently reported that a xenogeneic serum-free culture medium (XFM) is preferable to fetal ...

    Authors: Mai Mochizuki, Hiroshi Sagara and Taka Nakahara

    Citation: Stem Cell Research & Therapy 2020 11:267

    Content type: Research

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  16. Human umbilical cord mesenchymal stem cell (hUC-MSC) therapy is considered as a promising approach in the treatment of intrauterine adhesions (IUAs). Considerable researches have already detected hUC-MSCs by d...

    Authors: Jia-Hua Zheng, Jing-Kun Zhang, De-Sheng Kong, Yan-Biao Song, Shuang-Dan Zhao, Wen-Bo Qi, Ya-Nan Li, Ming-le Zhang and Xiang-Hua Huang

    Citation: Stem Cell Research & Therapy 2020 11:280

    Content type: Research

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  17. Stem cell senescence has been proposed as one of the major drivers of aging, and MSC senescence contributes to aging-related diseases. Activation of mTORC1 pathway and heterochromatin organization have been ch...

    Authors: Hailong Liu, Biao Huang, Shaolong Xue, Kin Pong U, Lai Ling Tsang, Xiaohu Zhang, Gang Li and Xiaohua Jiang

    Citation: Stem Cell Research & Therapy 2020 11:279

    Content type: Research

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  18. Diabetic cystopathy (DCP) is a chronic complication of diabetes mainly within the submucosal and muscular layers of the bladder due to the hyperglycemia-induced ischemia. As no effective therapies are currentl...

    Authors: Yi Huang, Jie Gao, Yiduo Zhou, Shuo Wu, Yunpeng Shao, Haoliang Xue, Baixin Shen, Liucheng Ding and Zhongqing Wei

    Citation: Stem Cell Research & Therapy 2020 11:278

    Content type: Research

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  19. Umbilical cord mesenchymal stem cells (UCMSCs) have been demonstrated to have good therapeutic effects in the treatment of HBV-related liver diseases. However, the therapeutic effect of UCMSCs on HBV-related l...

    Authors: Yifan Jia, Xin Shu, Xiaoan Yang, Haixia Sun, Huijuan Cao, Hong Cao, Ka Zhang, Qihuan Xu, Gang Li and Yang Yang

    Citation: Stem Cell Research & Therapy 2020 11:277

    Content type: Research

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  20. This study aimed to investigate the effect of bone marrow mesenchymal stem cell (BMSC)-derived exosome injection on cartilage damage and pain relief in both in vitro and in vivo models of osteoarthritis (OA).

    Authors: Lei He, Tianwei He, Jianghao Xing, Qing Zhou, Lei Fan, Can Liu, Yuyong Chen, Depeng Wu, Zhenming Tian, Bin Liu and Limin Rong

    Citation: Stem Cell Research & Therapy 2020 11:276

    Content type: Research

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  21. Mesenchymal stromal cells (MSCs) play an important role in the prevention of cell and tissue fibrosis. Senescence may decrease the function of MSCs during recovery from tissue and organ damage. Extracellular v...

    Authors: Yan Wang, Yi Fang Guo, Guang Ping Fu, Chang Guan, Xin Zhang, Dong Gang Yang and Yun Cong Shi

    Citation: Stem Cell Research & Therapy 2020 11:274

    Content type: Research

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  22. Age and other cardiovascular risk factors have been reported to impair the activities of mesenchymal stem cells (MSCs), which will affect the efficacy of stem cell transplantation. The objective of the study i...

    Authors: Ning Zhang, Jinyun Zhu, Qunchao Ma, Yun Zhao, Yingchao Wang, Xinyang Hu, Jinghai Chen, Wei Zhu, Zhongchao Han and Hong Yu

    Citation: Stem Cell Research & Therapy 2020 11:273

    Content type: Research

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  23. Adult clinical trials have reported safety and the therapeutic potential of stem cells for cardiac disease. These observations have now translated to the pediatric arena. We conducted a meta-analysis to assess...

    Authors: John Martinez, Sarah Zoretic, Axel Moreira and Alvaro Moreira

    Citation: Stem Cell Research & Therapy 2020 11:272

    Content type: Review

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  24. Mesenchymal stem cell (MSC)-based cartilage tissue regeneration is a treatment with great potential. How to enhance the MSC chondrogenic differentiation is a key issue involved in cartilage formation. In the p...

    Authors: Haoqing Yang, Yangyang Cao, Jianpeng Zhang, Yuncun Liang, Xiaomin Su, Chen Zhang, Huina Liu, Xiao Han, Lihua Ge and Zhipeng Fan

    Citation: Stem Cell Research & Therapy 2020 11:271

    Content type: Research

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  25. Prenatal dexamethasone exposure (PDE) induces low birth weight and retardation of fetal bone development which are associated with lower peak bone mass in adult offspring. Here we evaluated whether and how PDE...

    Authors: Jianwen Su, Yu Chai, Zhiguo Ji, Yongheng Xie, Bin Yu and Xianrong Zhang

    Citation: Stem Cell Research & Therapy 2020 11:270

    Content type: Research

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  26. Bone mass loss in aging is linked with imbalanced lineage differentiation of bone marrow mesenchymal stem cells (BMMSCs). Recent studies have proved that histone deacetylases (HDACs) are regarded as key regula...

    Authors: Liqiang Zhang, Meng Qi, Ji Chen, Jiangdong Zhao, Liya Li, Jiachen Hu, Yan Jin and Wenjia Liu

    Citation: Stem Cell Research & Therapy 2020 11:269

    Content type: Research

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  27. Previous studies of primary ovarian insufficiency (POI) have focused on granulosa cells (GCs) and ignored the role of theca-interstitial cells (TICs). This study aims to explore the mechanism of the protective...

    Authors: Xueyan Lu, Hongchu Bao, Linlu Cui, Wenqian Zhu, Lianshuang Zhang, Zheng Xu, Xuejing Man, Yongli Chu, Qiang Fu and Hongqin Zhang

    Citation: Stem Cell Research & Therapy 2020 11:268

    Content type: Research

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  28. Mesenchymal stem cells (MSCs) can provide therapeutic benefits for myocardial infarction (MI) recovery; however, the molecular mechanism by which MSCs improve the heart function is unclear.

    Authors: Baoping Deng, Xianlan Zhang, Yi Liang, Haiming Jiang, Weizhao Huang, Yinmeng Wu and Weiping Deng

    Citation: Stem Cell Research & Therapy 2020 11:266

    Content type: Research

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  29. Hemophagocytic lymphohistiocytosis (HLH) is a severe or even fatal inflammatory state. Epstein–Barr virus (EBV) infection-associated HLH (EBV-HLH) is one of the most common secondary HLH and suffers a very poo...

    Authors: Yue Song, Jingshi Wang, Yini Wang and Zhao Wang

    Citation: Stem Cell Research & Therapy 2020 11:265

    Content type: Research

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  30. Large numbers of adipose-derived stem cells (ADSCs) are easily obtained and have been demonstrated to protect against ultraviolet B (UVB)-induced skin photoaging. Extracellular vesicles (EVs) exhibit some of t...

    Authors: Peng Xu, Yu Xin, Zheng Zhang, Xiangyu Zou, Ke Xue, Huizhong Zhang, Wenjie Zhang and Kai Liu

    Citation: Stem Cell Research & Therapy 2020 11:264

    Content type: Research

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  31. Lamina-associated polypeptide 2α (LAP2α) is a nucleoplasmic protein that has been involved in the regulation of the cell cycle, gene transcription, and adult stem cell function. LAP2α down-regulation is linked...

    Authors: Yiman Tang, Xiao Zhang, Wenshu Ge and Yongsheng Zhou

    Citation: Stem Cell Research & Therapy 2020 11:263

    Content type: Research

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  32. Mesenchymal stem/stromal cells (MSC) are commonly used in regenerative medicine. Among different tissues, iliac crest bone marrow (BM) represents the most exploited source, but its disadvantages are a painful ...

    Authors: Katarzyna Drela, Luiza Stanaszek, Konrad Snioch, Zuzanna Kuczynska, Mikolaj Wrobel, Sylwia Sarzynska, Pawel Legosz, Pawel Maldyk and Barbara Lukomska

    Citation: Stem Cell Research & Therapy 2020 11:262

    Content type: Research

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  33. Wound healing is a complex biological process comprised of a series of sequential events aiming to repair injured tissue. Adult mesenchymal stem cells (MSCs) have been used in cellular therapy in preclinical a...

    Authors: Nathaly Enciso, Luis Avedillo, María Luisa Fermín, Cristina Fragío and Concepción Tejero

    Citation: Stem Cell Research & Therapy 2020 11:261

    Content type: Research

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  34. Mesenchymal stromal cell-derived exosomes (MSC-EXs) could exert protective effects on recipient cells by transferring the contained microRNAs (miRs), and miR-132-3p is one of angiogenic miRs. However, whether ...

    Authors: Qunwen Pan, Xiaoli Kuang, Shuyun Cai, Xiang Wang, Donghui Du, Jinju Wang, Yan Wang, Yanyu Chen, Ji Bihl, Yanfang Chen, Bin Zhao and Xiaotang Ma

    Citation: Stem Cell Research & Therapy 2020 11:260

    Content type: Research

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  35. After surgery, wound recovery in diabetic patients may be disrupted due to delayed inflammation, which can lead to undesired consequences, and there is currently a lack of effective measures to address this is...

    Authors: Wei Liu, Muyu Yu, Dong Xie, Longqing Wang, Cheng Ye, Qi Zhu, Fang Liu and Lili Yang

    Citation: Stem Cell Research & Therapy 2020 11:259

    Content type: Research

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  36. Prostate cancer stem-like cells (PCSCs) likely participate in tumor progression and recurrence and demonstrate resistance to chemotherapy. The Notch pathway plays a role in the maintenance of the stemness in P...

    Authors: Lei Wang, Hao Zi, Yi Luo, Tongzu Liu, Hang Zheng, Conghua Xie, Xinghuan Wang and Xing Huang

    Citation: Stem Cell Research & Therapy 2020 11:258

    Content type: Research

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  37. Schwann cells (SCs) are primarily responsible for regeneration and repair of the peripheral nervous system (PNS). Renewable and lineage-restricted SC precursors (SCPs) are considered highly desirable and promi...

    Authors: Han-Seop Kim, Jae Yun Kim, Cho Lok Song, Ji Eun Jeong and Yee Sook Cho

    Citation: Stem Cell Research & Therapy 2020 11:257

    Content type: Research

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  38. MSCTRAIL is a cell-based therapy consisting of human allogeneic umbilical cord-derived MSCs genetically modified to express the anti-cancer protein TRAIL. Though cell-based therapies are typically designed wit...

    Authors: P. Stephen Patrick, Krishna K. Kolluri, May Zaw Thin, Adam Edwards, Elizabeth K. Sage, Tom Sanderson, Benjamin D. Weil, John C. Dickson, Mark F. Lythgoe, Mark Lowdell, Sam M. Janes and Tammy L. Kalber

    Citation: Stem Cell Research & Therapy 2020 11:256

    Content type: Research

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  39. Clinical use of mesenchymal stem cells (MSCs) requires a uniform cell population, and their harvesting is invasive and produces a limited number of cells. Human embryonic stem cell-derived MSCs (hESC-MSCs) can...

    Authors: Sook Young Yoon, Jung Ah Yoon, Mira Park, Eun-Young Shin, Sookyung Jung, Jeoung Eun Lee, Jin Hee Eum, Haengseok Song, Dong Ryul Lee, Woo Sik Lee and Sang Woo Lyu

    Citation: Stem Cell Research & Therapy 2020 11:255

    Content type: Research

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  40. Human chronic graft-versus-host disease (CGVHD) shares clinical characteristics with a murine sclerodermatous GVHD (Scl-GVHD, B10.D2 → BALB/c) model that is characterized by skin and lung fibrosis. In this stu...

    Authors: Ji-Young Lim, Da-Bin Ryu, Tae Woo Kim, Sung-Eun Lee, Gyeongsin Park, Hyoung Kyu Yoon and Chang-Ki Min

    Citation: Stem Cell Research & Therapy 2020 11:254

    Content type: Research

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  41. Extracellular vesicles produced by bone marrow mesenchymal stem cells (BMSC-EVs) can play important roles in the repair of injured tissues. Though numerous studies have reported the effect of EVs on renal fibr...

    Authors: Zhengzhou Shi, Qi Wang, Youbo Zhang and Dapeng Jiang

    Citation: Stem Cell Research & Therapy 2020 11:253

    Content type: Research

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  42. Recently, extensive researches about stem cell-based therapies for ischemic stroke have been published; our review evaluated the efficacy and safety of stem cell-based therapies for ischemic stroke. Our review...

    Authors: Zhonghao Li, Xiaoke Dong, Min Tian, Chongchong Liu, Kaiyue Wang, Lili Li, Zunjing Liu and Jinmin Liu

    Citation: Stem Cell Research & Therapy 2020 11:252

    Content type: Review

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  43. GATA4 is an early cardiac-specific transcription factor, and endogenous GATA4-positive cells play a critical role in cardioprotection after myocardial injury. As functional paracrine units of therapeutic cells...

    Authors: Chunshu Hao, Zhengri Lu, Yuanyuan Zhao, Zhong Chen, Chengxing Shen, Genshan Ma and Lijuan Chen

    Citation: Stem Cell Research & Therapy 2020 11:251

    Content type: Research

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  44. Consumption of non-nutritive sweeteners (NNS) has been consistently associated with obesity and cardiometabolic disease in epidemiologic studies. Herein, we investigated effects of sucralose, a widely used NNS...

    Authors: Nabanita Kundu, Cleyton C. Domingues, Jay Patel, Mohammed Aljishi, Neeki Ahmadi, Mona Fakhri, Allison C. Sylvetsky and Sabyasachi Sen

    Citation: Stem Cell Research & Therapy 2020 11:250

    Content type: Research

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  45. The prevalence of kidney diseases is emerging as a public health problem. Stem cells (SCs), currently considered as a promising tool for therapeutic application, have aroused considerable interest and expectat...

    Authors: Dongwei Liu, Fei Cheng, Shaokang Pan and Zhangsuo Liu

    Citation: Stem Cell Research & Therapy 2020 11:249

    Content type: Review

    Published on:

  46. Melanoma is a type of aggressive skin cancer with a poor survival rate. The resistance to conventional therapy of this disease is, at least in part, attributed to its cancer stem cell population. However, the ...

    Authors: Wenlin Wu, Chenxi Xu, Xiaobo Zhang, An Yu and Le Shu

    Citation: Stem Cell Research & Therapy 2020 11:248

    Content type: Research

    Published on:

  47. Cardiopulmonary bypass (CPB) results in severe lung injury via inflammation and endothelial injury. The aim of this study was to evaluate the effect of endothelial colony-forming cells (ECFCs) on lung injury i...

    Authors: Haibin Sun, Xiaoqing Zhao, Qihang Tai, Guangxiao Xu, Yingnan Ju and Wei Gao

    Citation: Stem Cell Research & Therapy 2020 11:246

    Content type: Research

    Published on:

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