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  1. Studying cancer tumors’ microenvironment may reveal a novel role in driving cancer progression and metastasis. The biological interaction between stromal (mesenchymal) stem cells (MSCs) and cancer cells remain...

    Authors: Mashael Al-toub, Abdulaziz Almusa, Mohammed Almajed, May Al-Nbaheen, Moustapha Kassem, Abdullah Aldahmash and Nehad M Alajez
    Citation: Stem Cell Research & Therapy 2013 4:114
  2. Treatment of chronic skin wounds is difficult and largely ineffective. Little improvement has been shown in promoting the healing of these wounds in the past few decades. Innovative treatments to enhance chron...

    Authors: Yunling Li, Lei Zheng, Xia Xu, Lili Song, Yin Li, Wei Li, Suhan Zhang, Feng Zhang and Haiyan Jin
    Citation: Stem Cell Research & Therapy 2013 4:113
  3. Knowing the repertoire of cell signaling receptors would provide pivotal insight into the developmental and regenerative capabilities of bone marrow cell (BMC)-derived hematopoietic stem/progenitor cells (HSPC...

    Authors: Khairul Anam and Thomas A Davis
    Citation: Stem Cell Research & Therapy 2013 4:112
  4. Cell-based therapy represents a new frontier in the treatment of a wide variety of human diseases traditionally associated with morbidity outcomes, including those involving inflammation, autoimmunity, tissue ...

    Authors: Ikiru Atsuta, Shiyu Liu, Yasuo Miura, Kentaro Akiyama, Chider Chen, Ying An, Songtao Shi and Fa-Ming Chen
    Citation: Stem Cell Research & Therapy 2013 4:111
  5. MicroRNA-21 (miR-21) functions have been linked to cancer progression and chemo- or radiotherapy resistance. While an increasing number of studies have reported a potential role of miR-21 expression in promoti...

    Authors: Hong-Yo Kang
    Citation: Stem Cell Research & Therapy 2013 4:110
  6. Microspheres fabricated from natural materials serve as a promising biodegradable and biocompatible carrier in a small volume for efficient cell delivery to the lesion of the injured neural tissue to generate ...

    Authors: Li Yao, Francis Phan and Yongchao Li
    Citation: Stem Cell Research & Therapy 2013 4:109
  7. Bones adapt to accommodate the physical forces they experience through changes in architecture and mass. Stem cells differentiate into bone-forming osteoblasts, and mechanical stimulation is involved in this p...

    Authors: Julia C Chen and Christopher R Jacobs
    Citation: Stem Cell Research & Therapy 2013 4:107
  8. Advances in the fields of stem cell biology, biomaterials, and tissue engineering over the last decades have brought the possibility of constructing tissue substitutes with a broad range of applications in reg...

    Authors: Giuseppe Maria de Peppo and Darja Marolt
    Citation: Stem Cell Research & Therapy 2013 4:106
  9. To stimulate healing of large bone defects research has concentrated on the application of mesenchymal stem cells (MSCs).

    Authors: Johannes C Reichert, Jonas Schmalzl, Patrick Prager, Fabian Gilbert, Verena MC Quent, Andre F Steinert, Maximilian Rudert and Ulrich Nöth
    Citation: Stem Cell Research & Therapy 2013 4:105
  10. Potential stem cell niches (SNs) were recently reported in intervertebral discs (IVDs) and knee joints (KJs) in different mammals (located adjacent to the epiphyseal plate; EP). The aim here was to examine fur...

    Authors: Helena Barreto Henriksson, Anders Lindahl, Eva Skioldebrand, Katarina Junevik, Carolina Tängemo, Johan Mattsson and Helena Brisby
    Citation: Stem Cell Research & Therapy 2013 4:104
  11. The apoptosis and subsequent injury of podocytes plays a pathogenic role in diabetic nephropathy (DN). Mesenchymal stem cells (MSCs) are promising therapeutic cells for preventing apoptosis and reducing cellul...

    Authors: Diangeng Li, Nan Wang, Li Zhang, Zhu Hanyu, Bai Xueyuan, Bo Fu, Cui Shaoyuan, Weiguang Zhang, Sun Xuefeng, Rongshan Li and Xiangmei Chen
    Citation: Stem Cell Research & Therapy 2013 4:103
  12. Human neural stem cell transplants have potential as therapeutic candidates to treat a vast number of disorders of the central nervous system (CNS). StemCells, Inc. has purified human neural stem cells and dev...

    Authors: Ann Tsukamoto, Nobuko Uchida, Alexandra Capela, Thorsten Gorba and Stephen Huhn
    Citation: Stem Cell Research & Therapy 2013 4:102
  13. Over the past decade a lot of research has been performed towards the therapeutic use of mesenchymal stem cells (MSCs) in neurodegenerative and neuroinflammatory diseases. MSCs have shown to be beneficial in d...

    Authors: Nathalie De Vocht, Jelle Praet, Kristien Reekmans, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Zwi Berneman, Annemie Van der Linden and Peter Ponsaerts
    Citation: Stem Cell Research & Therapy 2013 4:101
  14. Twenty years ago glial cells were shown to contribute to neuronal information processing, instead of merely supporting neuronal function, thus challenging the century old neuron doctrine. Due to the lack of ap...

    Authors: Sonia Spitzer, Sylvia Agathou and Ragnhildur Thora Karadottir
    Citation: Stem Cell Research & Therapy 2013 4:100
  15. Guided migration of chondrogenically differentiated cells has not been well studied, even though it may be critical for growth, repair, and regenerative processes. The chemokine CCL25 is believed to play a cri...

    Authors: Mujib Ullah, Jan Eucker, Michael Sittinger and Jochen Ringe
    Citation: Stem Cell Research & Therapy 2013 4:99
  16. Heart diseases remain a major cause of mortality and morbidity worldwide. However, terminally differentiated human adult cardiomyocytes (CMs) possess a very limited innate ability to regenerate. Directed diffe...

    Authors: Maggie Zi Chow, Kenneth R Boheler and Ronald A Li
    Citation: Stem Cell Research & Therapy 2013 4:97
  17. Vascularization remains one of the primary obstacles in the repair of bone defects. In the previous issue of Stem Cell Research & Therapy, Pedersen and colleagues show that co-immobilization of endothelial cells ...

    Authors: Meadhbh Aín Brennan, Jean-Michel Davaine and Pierre Layrolle
    Citation: Stem Cell Research & Therapy 2013 4:96
  18. Retinal Müller cells exhibit the characteristics of retinal progenitor cells, and differentiate into ganglion cells under certain conditions. However, the number of ganglion cells differentiated from retinal M...

    Authors: Wei-tao Song, Xue-yong Zhang and Xiao-bo Xia
    Citation: Stem Cell Research & Therapy 2013 4:94
  19. Ischemic stroke is a leading cause of death and disability, but treatment options are severely limited. Cell therapy offers an attractive strategy for regenerating lost tissues and enhancing the endogenous hea...

    Authors: Danielle Drury-Stewart, Mingke Song, Osama Mohamad, Ying Guo, Xiaohuan Gu, Dongdong Chen and Ling Wei
    Citation: Stem Cell Research & Therapy 2013 4:93
  20. Multipotent mesenchymal stromal cells (MSCs) have gained considerable interest because of their potential use in the treatment of a variety of diseases and injuries. Although remarkable advancements have been ...

    Authors: Carolina Soares Barros Melo, Jerusa Araújo Quintão Arantes Faria, Natássia Caroline Resende Corrêa, Carolina de Andrade, Juliana Lott Carvalho, Alfredo M Goes, Michele A Rodrigues and Dawidson Assis Gomes
    Citation: Stem Cell Research & Therapy 2013 4:92
  21. Adipose-derived stem cells (ADSCs) have been isolated, expanded, and applied in the treatment of many diseases. ADSCs have also been used to treat injured articular cartilage. However, there is controversy reg...

    Authors: Phuc Van Pham, Khanh Hong-Thien Bui, Dat Quoc Ngo, Ngoc Bich Vu, Nhung Hai Truong, Nhan Lu-Chinh Phan, Dung Minh Le, Triet Dinh Duong, Thanh Duc Nguyen, Vien Tuong Le and Ngoc Kim Phan
    Citation: Stem Cell Research & Therapy 2013 4:91
  22. Experimental evidence has indicated a role of adult renal progenitor cells in kidney regeneration and a protective role of the kidney by erythropoietin (EPO) and suramin in animal models and in humans after ac...

    Authors: Pei-Rong Wang
    Citation: Stem Cell Research & Therapy 2013 4:89
  23. Resistance of cancer stem/progenitor cells (CSPCs) to chemotherapy can lead to cancer relapse. Ovarian teratocarcinoma (OVTC) arises from germ cells and comprises pluripotent cells that can be used to study ca...

    Authors: Wei-Min Chung, Wei-Chun Chang, Lumin Chen, Ying-Yi Chang, Chih-Rong Shyr, Yao-Ching Hung and Wen-Lung Ma
    Citation: Stem Cell Research & Therapy 2013 4:88
  24. The reprogramming of a patient’s somatic cells back into induced pluripotent stem cells (iPSCs) holds significant promise for future autologous cellular therapeutics. The continued presence of potentially onco...

    Authors: Jason P Awe, Patrick C Lee, Cyril Ramathal, Agustin Vega-Crespo, Jens Durruthy-Durruthy, Aaron Cooper, Saravanan Karumbayaram, William E Lowry, Amander T Clark, Jerome A Zack, Vittorio Sebastiano, Donald B Kohn, April D Pyle, Martin G Martin, Gerald S Lipshutz, Patricia E Phelps…
    Citation: Stem Cell Research & Therapy 2013 4:87
  25. BALB/c mice and C57/BL6 mice have different abilities to recover from ischemia. C57/BL6 mice display increased vessel collateralization and vascular endothelial growth factor expression with a consequent rapid...

    Authors: Flavia Franco Cunha, Leonardo Martins, Priscila Keiko Matsumoto Martin, Roberta Sessa Stilhano and Sang Won Han
    Citation: Stem Cell Research & Therapy 2013 4:86
  26. Tendon injury is a major cause of lameness and decreased performance in athletic equines. Various therapies for tendonitis have been described; however, none of these therapies results in complete tissue regen...

    Authors: Armandode Mattos Carvalho, Peres Ramos Badial, Luis Emiliano Cisneros Álvarez, Ana Lucia Miluzzi Yamada, Alexandre Secorun Borges, Elenice Deffune, Carlos Alberto Hussni and Ana Liz Garcia Alves
    Citation: Stem Cell Research & Therapy 2013 4:85
  27. Epidermal neural crest stem cells (EPI-NCSCs) in the bulge of hair follicles are a promising source for cell-replacement therapies in neurodegenerative diseases. A prominent factor in cell-based therapy is the...

    Authors: Sareh Pandamooz, Mohammad Naji, Farid Alinezhad, Amin Zarghami and Mohsen Pourghasem
    Citation: Stem Cell Research & Therapy 2013 4:84
  28. Bone marrow mesenchymal stem cells (BMMSCs) have been reported to facilitate liver regeneration after toxic injuries. However, the effect of BMMSCs on liver regeneration after massive hepatectomy is barely stu...

    Authors: Jun Yu, Shengyong Yin, Wu Zhang, Feng Gao, Yuanxing Liu, Zhiyun Chen, Min Zhang, Jiangjuan He and Shusen Zheng
    Citation: Stem Cell Research & Therapy 2013 4:83
  29. Although blinding is a methodologic safeguard to ensure obtaining comparability of groups in a clinical trial, it is very difficult to maintain blinding from the beginning to the end of a study. The aim of the...

    Authors: Hyunsuk Jeong, Hyeon Woo Yim, Youngseung Cho, Hun Jun Park, Sona Jeong, Hyun-bin Kim, Wonhee Hong and Heejung Kim
    Citation: Stem Cell Research & Therapy 2013 4:82
  30. Human Wharton’s jelly (WJ) has become a preferred source of mesenchymal stem cells (MSCs) whose clinical applications are limited by the use of adequate xeno-free (XF), in vitro manipulation conditions. Therefore...

    Authors: Maria Cristina Corotchi, Mirel Adrian Popa, Anca Remes, Livia Elena Sima, Ilinca Gussi and Marilena Lupu Plesu
    Citation: Stem Cell Research & Therapy 2013 4:81
  31. Young patients receiving chemotherapy occasionally face infertility and premature ovarian failure (POF). Numerous investigations reported that adipose-derived stem cells (ADSCs) transplantation could ameliorat...

    Authors: Min Sun, Shufang Wang, Yi Li, Ling Yu, Fang Gu, Changyong Wang and Yuanqing Yao
    Citation: Stem Cell Research & Therapy 2013 4:80
  32. Obesity, which is excessive expansion of white adipose tissue, is a major risk factor for several serious health issues, including diabetes, cardiovascular disease and cancer. Efforts to combat obesity and rel...

    Authors: Zachary A Schiller, Nathan R Schiele, James K Sims, Kyongbum Lee and Catherine K Kuo
    Citation: Stem Cell Research & Therapy 2013 4:79
  33. Nestin-expressing cells isolated from different human tissues reveal self-renewal capacity and a multilineage differentiation potential. In particular, adult stem/progenitor cell populations from exocrine glan...

    Authors: Anja Richter, Nicole Nissen, Peter Mailänder, Felix Stang, Frank Siemers, Charli Kruse and Sandra Danner
    Citation: Stem Cell Research & Therapy 2013 4:78
  34. Multiple sclerosis (MS) is the most common inflammatory demyelinating disorder of the central nervous system (CNS). Minocycline ameliorates the clinical severity of MS and exhibits antiinflammatory, neuroprote...

    Authors: Yun Hou, Chung Heon Ryu, Kwang Ywel Park, Seong Muk Kim, Chang Hyun Jeong and Sin-Soo Jeun
    Citation: Stem Cell Research & Therapy 2013 4:77
  35. Cell therapy is a potential therapeutic approach for neurodegenerative disorders, such as Alzheimer disease (AD). Neuronal differentiation of stem cells before transplantation is a promising procedure for cell...

    Authors: Hui Yang, Zhao Hong Xie, Li Fei Wei, Hong Na Yang, Shao Nan Yang, Zheng Yu Zhu, Ping Wang, Cui Ping Zhao and Jian Zhong Bi
    Citation: Stem Cell Research & Therapy 2013 4:76
  36. Mechanical factors play a crucial role in the development of articular cartilage in vivo. In this regard, tissue engineers have sought to leverage native mechanotransduction pathways to enhance in vitro stem cell...

    Authors: Christopher J O’Conor, Natasha Case and Farshid Guilak
    Citation: Stem Cell Research & Therapy 2013 4:61
  37. The corneal stroma is being increasingly recognized as a repository for stem cells. Like the limbal and endothelial niches, stromal stem cells often reside in the peripheral cornea and limbus. These peripheral...

    Authors: Khurram Hashmani, Matthew James Branch, Laura Elizabeth Sidney, Permesh Singh Dhillon, Megha Verma, Owen Douglas McIntosh, Andrew Hopkinson and Harminder Singh Dua
    Citation: Stem Cell Research & Therapy 2013 4:75
  38. So far, no effective therapy is available for acute kidney injury (AKI), a common and serious complication with high morbidity and mortality. Interest has recently been focused on the potential therapeutic eff...

    Authors: Xiao Han, Li Zhao, Guodong Lu, Junke Ge, Yalin Zhao, Shulu Zu, Mingzhen Yuan, Yuqiang Liu, Feng Kong, Zhiying Xiao and Shengtian Zhao
    Citation: Stem Cell Research & Therapy 2013 4:74
  39. Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hemat...

    Authors: Wai Feng Lim, Tomoko Inoue-Yokoo, Keai Sinn Tan, Mei I Lai and Daisuke Sugiyama
    Citation: Stem Cell Research & Therapy 2013 4:71
  40. Stroke is a major cause of permanent neurologic damage, with few effective treatments available to restore lost function. Induced pluripotent stem cells (iPSCs) have the potential to generate all cell types in vi...

    Authors: Ting Yuan, Wei Liao, Nian-Hua Feng, Yuan-Lei Lou, Xin Niu, Ai-Jun Zhang, Yang Wang and Zhi-Feng Deng
    Citation: Stem Cell Research & Therapy 2013 4:73
  41. Topical administration of eye drops is the major route for drug delivery to the cornea. Orbital fat-derived stem cells (OFSCs) possess an in vitro corneal epithelial differentiation capacity. Both the safety and ...

    Authors: Ko-Jo Lin, Mei-Xue Loi, Gi-Shih Lien, Chieh-Feng Cheng, Hsiang-Yin Pao, Yun-Chuang Chang, Andrea Tung-Qian Ji and Jennifer Hui-Chun Ho
    Citation: Stem Cell Research & Therapy 2013 4:72
  42. Mesenchymal stem cells (MSCs) are known to migrate to tumor tissues. This behavior of MSCs has been exploited as a tumor-targeting strategy for cell-based cancer therapy. However, the effects of MSCs on tumor ...

    Authors: Ting Zhang, Yuk Wai Lee, Yun Feng Rui, Tin Yan Cheng, Xiao Hua Jiang and Gang Li
    Citation: Stem Cell Research & Therapy 2013 4:70
  43. The use of immortalized neural stem cells either as models of neural development in vitro or as cellular therapies in central nervous system (CNS) disorders has been controversial. This controversy has centered o...

    Authors: Graham Cocks, Nataliya Romanyuk, Takashi Amemori, Pavla Jendelova, Oksana Forostyak, Aaron R Jeffries, Leo Perfect, Sandrine Thuret, Govindan Dayanithi, Eva Sykova and Jack Price
    Citation: Stem Cell Research & Therapy 2013 4:69
  44. Platelet-rich plasma (PRP) is nowadays widely applied in different clinical scenarios, such as orthopedics, ophthalmology and healing therapies, as a growth factor pool for improving tissue regeneration. Studi...

    Authors: Paola Romina Amable, Rosana Bizon Vieira Carias, Marcus Vinicius Telles Teixeira, Ítalo da Cruz Pacheco, Ronaldo José Farias Corrêa do Amaral, José Mauro Granjeiro and Radovan Borojevic
    Citation: Stem Cell Research & Therapy 2013 4:67
  45. Because of their multi/pluripotency and immunosuppressive properties, mesenchymal stem/stromal cells (MSCs) are important tools for treating immune disorders and for tissue repair. The increasing use of MSCs, ...

    Authors: Luc Sensebé, Mélanie Gadelorge and Sandrine Fleury-Cappellesso
    Citation: Stem Cell Research & Therapy 2013 4:66

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