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  1. The adult mammalian brain retains niches for neural stem cells (NSCs), which can generate glial and neuronal components of the brain tissue. However, it is barely established how chronic neuroinflammation, as ...

    Authors: Maik MA Worlitzer, Eva C Bunk, Kathrin Hemmer and Jens C Schwamborn
    Citation: Stem Cell Research & Therapy 2012 3:33
  2. The influence of genetic background on the ability to generate induced pluripotent stem cells (iPSCs) has the potential to impact future applications, but has yet to be examined in detail. The purpose of this ...

    Authors: Lauren V Schnabel, Christian M Abratte, John C Schimenti, Teresa L Southard and Lisa A Fortier
    Citation: Stem Cell Research & Therapy 2012 3:30
  3. Embryonic stem cells (ESCs) provide an attractive cell source for basic research and disease treatment. Currently, the common culture system for mouse ESC requires mouse embryonic fibroblast (MEF) as a feeder ...

    Authors: Yu Ma, Junjie Gu, Chunliang Li, Xiaoyuan Wei, Fan Tang, Guilai Shi, Jing Jiang, Ying Kuang, Jinsong Li, Zhugang Wang, Xin Xie and Ying Jin
    Citation: Stem Cell Research & Therapy 2012 3:29
  4. The remarkable speed with which the field of stem cell biology has evolved is unprecedented and has already changed the way we do science. In this series of articles we have invited leading experts to present ...

    Authors: Mahendra Rao
    Citation: Stem Cell Research & Therapy 2012 3:27
  5. Aastrom Biosciences has developed a proprietary cell-processing technology that enables the manufacture of ixmyelocel-T, a patient-specific multicellular therapy expanded from a small sample of a patient's own...

    Authors: Ronnda L Bartel, Caryn Cramer, Kelly Ledford, Amy Longcore, Christopher Parrish, Theresa Stern, Sharon Watling and Frank Zeigler
    Citation: Stem Cell Research & Therapy 2012 3:26
  6. Osteoarthritis (OA) is a degenerative disease of the connective tissue and progresses with age in the older population or develops in young athletes following sports-related injury. The articular cartilage is ...

    Authors: Pawan K Gupta, Anjan K Das, Anoop Chullikana and Anish S Majumdar
    Citation: Stem Cell Research & Therapy 2012 3:25
  7. Injury and disease of the spinal cord are generally met with a poor prognosis. This poor prognosis is due not only to the characteristics of the diseases but also to our poor ability to deliver therapeutics to...

    Authors: Eleanor M Donnelly, Jason Lamanna and Nicholas M Boulis
    Citation: Stem Cell Research & Therapy 2012 3:24
  8. Endothelial progenitor cells (EPC) capable of initiating or augmenting vascular growth were recently identified within the small population of CD34-expressing cells that circulate in human peripheral blood and...

    Authors: G Robin Barclay, Olga Tura, Kay Samuel, Patrick WF Hadoke, Nicholas L Mills, David E Newby and Marc L Turner
    Citation: Stem Cell Research & Therapy 2012 3:23
  9. Transplantation of genetically modified human bone marrow-derived mesenchymal stem cells (hMSCs) with an accurate potential for chondrogenic differentiation may be a powerful means to enhance the healing of ar...

    Authors: Jagadeesh K Venkatesan, Myriam Ekici, Henning Madry, Gertrud Schmitt, Dieter Kohn and Magali Cucchiarini
    Citation: Stem Cell Research & Therapy 2012 3:22
  10. Ageing is a biological certainty for all living organisms, and is due to the loss of tissue homeostasis and regenerative capacity (except for newts) in which somatic stem cells are thought to play an important...

    Authors: Karl JA McCullagh
    Citation: Stem Cell Research & Therapy 2012 3:19
  11. It is hypothesized that administration of stromal/stem cells isolated from the adipose tissue (ASCs) and umbilical cord (HUCPVCs) can ameliorate the injured central nervous system (CNS). It is still not clear,...

    Authors: Carlos A Ribeiro, Joana S Fraga, Mário Grãos, Nuno M Neves, Rui L Reis, Jeffrey M Gimble, Nuno Sousa and António J Salgado
    Citation: Stem Cell Research & Therapy 2012 3:18
  12. The clinical use of stem cells, such as bone marrow-derived and, more recently, resident cardiac stem cells, offers great promise for treatment of myocardial infarction and heart failure. The epicardium-derive...

    Authors: Nenad Bursac
    Citation: Stem Cell Research & Therapy 2012 3:15
  13. Stem cells have tremendous applications in the field of regenerative medicine and tissue engineering. These are pioneering fields that aim to create new treatments for disease that currently have limited thera...

    Authors: Ian Wimpenny, Hareklea Markides and Alicia J El Haj
    Citation: Stem Cell Research & Therapy 2012 3:13
  14. Down syndrome (DS), a major cause of mental retardation, is caused by trisomy of some or all of human chromosome 21 and includes three basic karyotypes: trisomy 21, translocation, and mosaicism. The derivation...

    Authors: Xiaoning Mou, Yuanbo Wu, Henghua Cao, Qingzhang Meng, Qihui Wang, Chengchao Sun, Shengshou Hu, Yue Ma and Hao Zhang
    Citation: Stem Cell Research & Therapy 2012 3:14
  15. The development of reproducible methods for deriving human embryonic stem cell (hESC) lines in compliance with good manufacturing practice (GMP) is essential for the development of hESC-based therapies. Althou...

    Authors: Nilendran Prathalingam, Linda Ferguson, Lesley Young, Georg Lietz, Rachel Oldershaw, Lyn Healy, Albert Craig, Helen Lister, Rakesh Binaykia, Radhika Sheth, Alison Murdoch and Mary Herbert
    Citation: Stem Cell Research & Therapy 2012 3:12
  16. Tissues characterized by constant turnover contain post-mitotic, terminally differentiated cells originating from highly proliferative progenitors, which in turn derive from a relatively small population of st...

    Authors: Roberta Sottocornola and Cristina Lo Celso
    Citation: Stem Cell Research & Therapy 2012 3:10
  17. Induced pluripotent stem (iPS) cells, obtained from reprogramming somatic cells by ectopic expression of a defined set of transcription factors or chemicals, are expected to be used as differentiated cells for...

    Authors: Tohru Sugawara, Koichiro Nishino, Akihiro Umezawa and Hidenori Akutsu
    Citation: Stem Cell Research & Therapy 2012 3:8
  18. The capacity of bone marrow mesenchymal stromal cells (BMSCs) to be induced into chondrocytes has drawn much attention for cell-based cartilage repair. BMSCs represent a small proportion of cells of the bone m...

    Authors: Adetola B Adesida, Aillette Mulet-Sierra and Nadr M Jomha
    Citation: Stem Cell Research & Therapy 2012 3:9
  19. Avascular necrosis (AVN) of the femoral head is a debilitating disease of multifactorial genesis, predominately affects young patients, and often leads to the development of secondary osteoarthritis. The evolv...

    Authors: Lars Rackwitz, Lars Eden, Stephan Reppenhagen, Johannes C Reichert, Franz Jakob, Heike Walles, Oliver Pullig, Rocky S Tuan, Maximilian Rudert and Ulrich Nöth
    Citation: Stem Cell Research & Therapy 2012 3:7
  20. Mesenchymal stem cells (MSCs) are multipotent cells able to differentiate into several mesenchymal lineages, classically derived from bone marrow (BM) but potentially from umbilical cord blood (UCB). Although ...

    Authors: Nesrine Ben Azouna, Faouzi Jenhani, Zohra Regaya, Lamia Berraeis, Tarek Ben Othman, Elfi Ducrocq and Jorge Domenech
    Citation: Stem Cell Research & Therapy 2012 3:6
  21. Glioma stem cells (GSCs) have the property of self-renewal and appear to be a driving force for the initiation and recurrence of gliomas. We recently found that the human tumorigenic LN-229 glioma cell line fa...

    Authors: Lei Wang, Ziyan Liu, Sivasai Balivada, Tej Shrestha, Stefan Bossmann, Marla Pyle, Loretta Pappan, Jishu Shi and Deryl Troyer
    Citation: Stem Cell Research & Therapy 2012 3:5
  22. Human induced pluripotent stem cells offer the possibility of generating unlimited quantities of cells for autologous transplantation. By correcting the genetic defect underlying Z-allele α1-antitrypsin deficienc...

    Authors: S Tamir Rashid and David A Lomas
    Citation: Stem Cell Research & Therapy 2012 3:4
  23. Stem cells are currently seen as a treatment for tissue regeneration in neurological diseases such as multiple sclerosis, anticipating that they integrate and differentiate into neural cells. Mesenchymal stem ...

    Authors: Sara Morando, Tiziana Vigo, Marianna Esposito, Simona Casazza, Giovanni Novi, Maria Cristina Principato, Roberto Furlan and Antonio Uccelli
    Citation: Stem Cell Research & Therapy 2012 3:3
  24. Stem cell transplantation is emerging as a potential therapy to treat heart diseases. Promising results from early animal studies led to an explosion of small, non-controlled clinical trials that created even ...

    Authors: Samer Arnous, Abdul Mozid, John Martin and Anthony Mathur
    Citation: Stem Cell Research & Therapy 2012 3:2
  25. For many years, the hematopoietic stem cell (HSC) has been well characterized in mice as a cell that can singly reconstitute the whole hematopoietic system of primary recipient animals as well as that of secon...

    Authors: Rhodri Ceredig
    Citation: Stem Cell Research & Therapy 2012 3:1
  26. Distinct stem cell types have been established from embryos and identified in the fetal tissues and umbilical cord blood as well as in specific niches in many adult mammalian tissues and organs such as bone ma...

    Authors: Rubens Camargo Siqueira
    Citation: Stem Cell Research & Therapy 2011 2:50
  27. A clinical trial using human embryonic stem cell (hESC) therapy for an inherited retinal degenerative disease is about to commence. The Advanced Cell Technology (ACT) trial will treat patients with Stargardt's...

    Authors: Reinhold J Medina, Desmond B Archer and Alan W Stitt
    Citation: Stem Cell Research & Therapy 2011 2:47
  28. End-stage renal disease (ESRD) is a major public health problem. Although kidney transplantation is a viable therapeutic option, this therapy is associated with significant limitations, including a shortage of...

    Authors: Tayaramma Thatava, Adam S Armstrong, Josep Genebriera De Lamo, Ramakrishna Edukulla, Yulia Krotova Khan, Toshie Sakuma, Seiga Ohmine, Jamie L Sundsbak, Peter C Harris, Yogish C Kudva and Yasuhiro Ikeda
    Citation: Stem Cell Research & Therapy 2011 2:48
  29. Specialized microenvironments called niches help maintain stem cells in an undifferentiated and self-renewing state. The existence of niches has long been predicted from mammalian studies, but identifying stem...

    Authors: Susan Eliazer and Michael Buszczak
    Citation: Stem Cell Research & Therapy 2011 2:45
  30. The induced pluripotent stem cell (iPSC) technology allows generation of patient-specific pluripotent stem cells, thereby providing a novel cell-therapy platform for severe degenerative diseases. One of the ke...

    Authors: Seiga Ohmine, Allan B Dietz, Michael C Deeds, Katherine A Hartjes, David R Miller, Tayaramma Thatava, Toshie Sakuma, Yogish C Kudva and Yasuhiro Ikeda
    Citation: Stem Cell Research & Therapy 2011 2:46
  31. Mesenchymal stem cells (MSCs) play a central role in mediating endogenous repair of cell and tissue damage. Biologic aging is a universal process that results in changes at the cellular and molecular levels. I...

    Authors: Amitabh C Pandey, Julie A Semon, Deepak Kaushal, Regina P O'Sullivan, Julie Glowacki, Jeffery M Gimble and Bruce A Bunnell
    Citation: Stem Cell Research & Therapy 2011 2:49
  32. Chronic ischemic heart disease is a major cause of patient morbidity and healthcare expenditure. The development of therapies aimed to enhance angiogenesis is targeted for patients with severe ischemic symptom...

    Authors: Peter J Psaltis and Robert D Simari
    Citation: Stem Cell Research & Therapy 2011 2:43
  33. Owing to their potential for differentiation into multiple cell types, multipotent stem cells extracted from many adult tissues are an attractive stem cell resource for the replacement of damaged tissues in re...

    Authors: María Berdasco and Manel Esteller
    Citation: Stem Cell Research & Therapy 2011 2:42
  34. There are many similarities between health issues affecting military and civilian patient populations, with the exception of the relatively small but vital segment of active soldiers who experience high-energy...

    Authors: Gregory T Christopherson and Leon J Nesti
    Citation: Stem Cell Research & Therapy 2011 2:40
  35. Amyloid precursor protein (APP) fascinates cell biologists because it is proteolytically processed to generate multiple peptides, including amyloid-β, which is implicated in Alzheimer's disease. However, a lar...

    Authors: Sanjay W Pimplikar and Kaushik Ghosal
    Citation: Stem Cell Research & Therapy 2011 2:39
  36. Stem cell transplantation is a promising therapeutic strategy for the treatment of stroke. Mesenchymal stem cells (MSCs) are a potential cell source for clinical application because they can be easily obtained...

    Authors: Jung Yeon Lim, Chang Hyun Jeong, Jin Ae Jun, Seong Muk Kim, Chung Heon Ryu, Yun Hou, Wonil Oh, Jong Wook Chang and Sin-Soo Jeun
    Citation: Stem Cell Research & Therapy 2011 2:38
  37. Soluble amyloid precursor protein α (sAPPα) is a proteolyte of APP cleavage by α-secretase. The significance of the cleavage and the physiological role of sAPPα are unknown. A crystal structure of a region of ...

    Authors: Michael P Demars, Amelia Bartholomew, Zuzana Strakova and Orly Lazarov
    Citation: Stem Cell Research & Therapy 2011 2:36
  38. Mesenchymal stem (stromal) cells (MSCs) are rare, multipotent progenitor cells that can be isolated and expanded from bone marrow and other tissues. Strikingly, MSCs modulate the functions of immune cells, inc...

    Authors: Michelle M Duffy, Thomas Ritter, Rhodri Ceredig and Matthew D Griffin
    Citation: Stem Cell Research & Therapy 2011 2:34
  39. A great number of patients around the world experience tooth loss that is attributed to irretrievable damage of the periodontium caused by deep caries, severe periodontal diseases or irreversible trauma. The p...

    Authors: Hidefumi Maeda, Atsushi Tomokiyo, Shinsuke Fujii, Naohisa Wada and Akifumi Akamine
    Citation: Stem Cell Research & Therapy 2011 2:33

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