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  1. Mesenchymal stem cells (MSCs) are multipotent and have been derived from various tissues. Although MSCs share many basic features, they often display subtle tissue specific differences. We previously demonstra...

    Authors: Orly Ravid, Ofer Shoshani, Meirav Sela, Ada Weinstock, Tommy Weiss Sadan, Eyal Gur, Dov Zipori and Nir Shani
    Citation: Stem Cell Research & Therapy 2014 5:139
    Content type: Research Published on:

  2. Scleroderma is characterized by cutaneous manifestations that mainly affect the hands, arms and face. As of today, there is no treatment for fibrotic skin lesions of scleroderma. Previously we generated and va...

    Authors: Nicolas Serratrice, Laurie Bruzzese, Jérémy Magalon, Julie Véran, Laurent Giraudo, Houssein Aboudou, Djaffar Ould-Ali, Pierre Sébastien Nguyen, Olivier Bausset, Aurélie Daumas, Dominique Casanova, Brigitte Granel, Lucile Andrac-Meyer, Florence Sabatier and Guy Magalon
    Citation: Stem Cell Research & Therapy 2014 5:138
    Content type: Research Published on:

  4. Mesenchymal stem cells (MSCs) are considered to play important roles in wound repair and tissue remodeling. Hypertrophic scar (HTS) is a cutaneous condition characterized by deposits of excessive amount of col...

    Authors: Yi-Lun Liu, Wei-Hua Liu, Jin Sun, Tuan-Jie Hou, Yue-Ming Liu, Hai-Rong Liu, Yong-Hui Luo, Ning-Ning Zhao, Ying Tang and Feng-Mei Deng
    Citation: Stem Cell Research & Therapy 2014 5:136
    Content type: Research Published on:

  5. Dental follicle gives rise to one or several tissues of the periodontium including the periodontal ligament, cementum and/or alveolar bone. Whether Wnt5a is expressed in the postnatal periodontium or regulates...

    Authors: Lusai Xiang, Mo Chen, Ling He, Bin Cai, Yu Du, Xinchun Zhang, Chen Zhou, Chenglin Wang, Jeremy J Mao and Junqi Ling
    Citation: Stem Cell Research & Therapy 2014 5:135
    Content type: Research Published on:

  6. Mesenchymal stem cells (MSCs) are a multipotent population of adult stem cells, which may represent a promising therapeutic approach for neurological autoimmune diseases such as multiple sclerosis. The mouse i...

    Authors: Carmen Marin-Bañasco, Margarita Suardíaz García, Issac Hurtado Guerrero, Rafael Maldonado Sánchez, Guillermo Estivill-Torrús, Laura Leyva Fernández and Oscar Fernández Fernández
    Citation: Stem Cell Research & Therapy 2014 5:134
    Content type: Research Published on:

  7. Rhinosinusitis is characterized by inflammation extending from the mucosa of the nasal cavity into the paranasal sinuses. There are some aggravating features, such as immunosuppression, that can cause the nasa...

    Authors: Erica Ortiz, Albina Altemani, Afonso Celso Vigorito, Eulalia Sakano and Ester Maria Danielli Nicola
    Citation: Stem Cell Research & Therapy 2014 5:133
    Content type: Research Published on:

  8. Mesenchymal stem cells (MSCs) are widely investigated in clinical researches to treat various diseases. Classic culture medium for MSCs, even for clinical use, contains fetal bovine serum. The serum-containing...

    Authors: Youwei Wang, Hehe Wu, Zhouxin Yang, Ying Chi, Lei Meng, Aibin Mao, Shulin Yan, Shanshan Hu, Jianzhong Zhang, Yun Zhang, Wenbo Yu, Yue Ma, Tao Li, Yan Cheng, Yongjuan Wang, Shanshan Wang…
    Citation: Stem Cell Research & Therapy 2014 5:132
    Content type: Research Published on:

  9. The present study aimed to elucidate the therapeutic effects of mesenchymal stem cells (MSCs) derived from the bone marrow of rats (BM) against toxic effects of lead (Pb) on the male gonads of experimental rats.

    Authors: Amal I Hassan and Sally S Alam
    Citation: Stem Cell Research & Therapy 2014 5:131
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2017 8:32

  10. Mesenchymal stem cells (MSCs) transplantation has been demonstrated to be an effective strategy for the treatment of cardiovascular disease. However, the low survival rate of MSCs at local diseased tissue redu...

    Authors: Yue Xing, Jingying Hou, Tianzhu Guo, Shaoxin Zheng, Changqing Zhou, Hui Huang, Yuyang Chen, Kan Sun, Tingting Zhong, Jingfeng Wang, Honghao Li and Tong Wang
    Citation: Stem Cell Research & Therapy 2014 5:130
    Content type: Research Published on:

  11. Clinically, a good deal of injury from stroke results from ischemic-reperfusion. There is a loss of cerebral parenchyma and its associated cells, disruption of neuronal connections, compromise of the blood-bra...

    Authors: Lei Huang, Sunnie Wong, Evan Y Snyder, Milton H Hamblin and Jean-Pyo Lee
    Citation: Stem Cell Research & Therapy 2014 5:129
    Content type: Research Published on:

  13. There is a growing interest in the therapeutic utility of compounds derived from Curcuma longa, an herb of the Zingiberaceae family that has been part of traditional medicine for centuries. Recent reports suggest...

    Authors: Steven W Poser and Andreas Androutsellis-Theotokis
    Citation: Stem Cell Research & Therapy 2014 5:127
    Content type: Commentary Published on:

  14. The administration of stem cells holds promise as a potential therapy for spinal cord injury (SCI). Mesenchymal stem cells have advantages for clinical applications, since they can be easily obtained, are suit...

    Authors: Marcus Vinícius Pinheiro Mendonça, Ticiana Ferreira Larocca, Bruno Solano de Freitas Souza, Cristiane Flora Villarreal, Luiz Flávio Maia Silva, André Costa Matos, Marco Antonio Novaes, Cláudia Maria Pinheiro Bahia, Ana Carine de Oliveira Melo Martinez, Carla Martins Kaneto, Sissi Brandão Carneiro Furtado, Geraldo Pedral Sampaio, Milena Botelho Pereira Soares and Ricardo Ribeiro dos Santos
    Citation: Stem Cell Research & Therapy 2014 5:126
    Content type: Research Published on:

  15. Estrogen plays an important role in the osteogenic differentiation of mesenchymal stem cells, while stem cells from apical papilla (SCAP) can contribute to the formation of dentin/bone-like tissues. To date, t...

    Authors: Yao Li, Ming Yan, Zilu Wang, Yangyu Zheng, Junjun Li, Shu Ma, Genxia Liu and Jinhua Yu
    Citation: Stem Cell Research & Therapy 2014 5:125
    Content type: Research Published on:

  16. Several cellular sources of stem cells have been tested in the attempt to yield innovative interventions in acute kidney injury (AKI). Human liver stem cells (HLSCs) are cells isolated from the normal adult hu...

    Authors: Maria Beatriz Herrera Sanchez, Stefania Bruno, Cristina Grange, Marta Tapparo, Vincenzo Cantaluppi, Ciro Tetta and Giovanni Camussi
    Citation: Stem Cell Research & Therapy 2014 5:124
    Content type: Research Published on:

  17. Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible fibrotic lung disease, resulting in respiratory insufficiency and reduced survival. Pulmonary fibrosis is a result of repeated alveolar epi...

    Authors: Amiq Gazdhar, Iwona Grad, Luca Tamò, Mathias Gugger, Anis Feki and Thomas Geiser
    Citation: Stem Cell Research & Therapy 2014 5:123
    Content type: Research Published on:

  18. Fibrosis, or scar formation, is a pathological condition characterized by excessive production and accumulation of collagen, loss of tissue architecture, and organ failure in response to uncontrolled wound hea...

    Authors: Alexander Birbrair, Tan Zhang, Daniel Clark Files, Sandeep Mannava, Thomas Smith, Zhong-Min Wang, Maria Laura Messi, Akiva Mintz and Osvaldo Delbono
    Citation: Stem Cell Research & Therapy 2014 5:122
    Content type: Research Published on:

  19. The use of hematopoietic cell transplantation (HCT) has previously been shown to ameliorate cutaneous blistering in pediatric patients with recessive dystrophic epidermolysis bullosa (RDEB), an inherited skin ...

    Authors: Christopher Perdoni, John A McGrath and Jakub Tolar
    Citation: Stem Cell Research & Therapy 2014 5:121
    Content type: Research Published on:

  21. Ocular trauma is defined as a trauma caused by blunt or penetrating mechanisms on the eyeball and its peripheral structures, causing damage with different degrees of affection with temporary or permanent visua...

    Authors: Gustavo Jesús Vázquez-Zapién, Marlon Rojas-López, Raúl Jacobo Delgado-Macuil, Luis Rubén Martínez-Nava, David Guillermo Pérez-Ishiwara and Mónica Maribel Mata-Miranda
    Citation: Stem Cell Research & Therapy 2014 5:119
    Content type: Research Published on:

  22. In the field of skin tissue engineering, gelatin-chondroitin-6-sulfate-hyaluronic acid (Gel-C6S-HA) stents are a suitable bio skin substitute. The purpose was to investigate the effect of genetically-modified ...

    Authors: Renfu Quan, Xuan Zheng, Shichao Xu, Liang Zhang and Disheng Yang
    Citation: Stem Cell Research & Therapy 2014 5:118
    Content type: Research Published on:

  23. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are the most promising source of cardiomyocytes (CMs) for experimental and clinical applications, but their use is largely limited by a structurall...

    Authors: Renjun Zhu, Adriana Blazeski, Ellen Poon, Kevin D Costa, Leslie Tung and Kenneth R Boheler
    Citation: Stem Cell Research & Therapy 2014 5:117
    Content type: Review Published on:

  24. The existence of cancer stem cells (CSCs) has been associated with tumor initiation, therapy resistance, tumor relapse, angiogenesis, and metastasis. Curcumin, a plant ployphenol, has several anti-tumor effect...

    Authors: Shravanti Mukherjee, Minakshi Mazumdar, Samik Chakraborty, Argha Manna, Shilpi Saha, Poulami Khan, Pushpak Bhattacharjee, Deblina Guha, Arghya Adhikary, Sanhita Mukhjerjee and Tanya Das
    Citation: Stem Cell Research & Therapy 2014 5:116
    Content type: Research Published on:

  25. Avascular necrosis of femoral head (ANFH) is a progressive disease that often leads to hip joint dysfunction and even disability in young patients. Although the standard treatment, which is core decompression,...

    Authors: Yuanchen Ma, Tao Wang, Junxing Liao, Honglin Gu, Xinpeng Lin, Qing Jiang, Max K Bulsara, Minghao Zheng and Qiujian Zheng
    Citation: Stem Cell Research & Therapy 2014 5:115
    Content type: Research Published on:

  26. Repair of large bone defects remains a significant clinical challenge. Bone marrow stromal cells (BMSCs), a subset of which is known as bone marrow-derived mesenchymal stem cells, show therapeutic potential fo...

    Authors: Meadhbh Á Brennan, Audrey Renaud, Jérôme Amiaud, Markus T Rojewski, Hubert Schrezenmeier, Dominique Heymann, Valerie Trichet and Pierre Layrolle
    Citation: Stem Cell Research & Therapy 2014 5:114
    Content type: Research Published on:

  27. Adipose-derived stroma cells (ASCs) are attractive cells for cell-based gene therapy but are generally difficult to transfect. Nucleofection has proven to be an efficient method for transfection of primary cel...

    Authors: Angela Fülbier, Reinhild Schnabel, Stefanie Michael, Peter M Vogt, Sarah Strauß, Kerstin Reimers and Christine Radtke
    Citation: Stem Cell Research & Therapy 2014 5:113
    Content type: Research Published on:

  28. Mesenchymal stem cells have been increasingly used for cell-based therapies. Adipose-derived stem/stromal cells (ASCs) from the stromal vascular fraction (SVF) of fat tissue are a particularly attractive optio...

    Authors: Hetal D Marble, Bryan A Sutermaster, Manisha Kanthilal, Vera C Fonseca and Eric M Darling
    Citation: Stem Cell Research & Therapy 2014 5:145
    Content type: Research Published on:

  29. Mesenchymal stem cells (MSCs) have the ability to differentiate into osteoblasts, chondroblasts, adipocytes, and even myoblasts. Most studies have focused on finding MSCs in different parts of the body for med...

    Authors: Eduardo Branco de Sousa, Priscila Ladeira Casado, Vivaldo Moura Neto, Maria Eugenia Leite Duarte and Diego Pinheiro Aguiar
    Citation: Stem Cell Research & Therapy 2014 5:112
    Content type: Review Published on:

  30. Aromatic (ar-) turmerone is a major bioactive compound of the herb Curcuma longa. It has been suggested that ar-turmerone inhibits microglia activation, a property that may be useful in treating neurodegenerative...

    Authors: Joerg Hucklenbroich, Rebecca Klein, Bernd Neumaier, Rudolf Graf, Gereon Rudolf Fink, Michael Schroeter and Maria Adele Rueger
    Citation: Stem Cell Research & Therapy 2014 5:100
    Content type: Research Published on:

  31. Poor cell survival and limited functional benefits have restricted the efficacy of bone marrow mesenchymal stem cells (BMSCs) in the treatment of myocardial infarction. We showed recently that hypoxia precondi...

    Authors: Xian-Bao Liu, Jian-An Wang, Xiao-Ya Ji, Shan Ping Yu and Ling Wei
    Citation: Stem Cell Research & Therapy 2014 5:111
    Content type: Research Published on:

  32. Myocardial infarction is accompanied by a significant loss of cardiomyocytes (CMs). Functional CMs, differentiated from human embryonic stem cells (hESCs), offer a potentially unlimited cell source for cardiac...

    Authors: Alan Tin-Lun Lam, Allen Kuan-Liang Chen, Jian Li, William R Birch, Shaul Reuveny and Steve Kah-Weng Oh
    Citation: Stem Cell Research & Therapy 2014 5:110
    Content type: Research Published on:

  33. Systemic administration of mesenchymal stem (stromal) cells (MSCs) has shown benefit in a range of experimental models of acute kidney injury, although the reported mechanisms of action and requirement for MSC...

    Authors: Michelle M Duffy and Matthew D Griffin
    Citation: Stem Cell Research & Therapy 2014 5:109
    Content type: Commentary Published on:

  34. Asthma is characterized by a chronic inflammatory process which may lead to several changes in bone marrow cell composition. We hypothesized that bone marrow mononuclear cells (BMMCs) obtained from ovalbumin (...

    Authors: Soraia C Abreu, Mariana A Antunes, Lucas Mendonça, Vivian C Branco, Elga Bandeira de Melo, Priscilla C Olsen, Bruno L Diaz, Daniel J Weiss, Bruno D Paredes, Debora G Xisto, Marcelo M Morales and Patricia RM Rocco
    Citation: Stem Cell Research & Therapy 2014 5:108
    Content type: Research Published on:

  35. Preterm newborns often require mechanical respiratory support that can result in ventilation-induced lung injury (VILI), despite exogenous surfactant treatment. Human amnion epithelial cells (hAECs) reduce lun...

    Authors: Courtney A McDonald, Jacqueline M Melville, Graeme R Polglase, Graham Jenkin and Timothy JM Moss
    Citation: Stem Cell Research & Therapy 2014 5:107
    Content type: Research Published on:

  36. Despite numerous research efforts, mechanisms underlying regeneration of pancreas remains controversial. Views are divided whether stem cells are involved during pancreatic regeneration or it involves duplicat...

    Authors: Deepa Bhartiya, Akash Mundekar, Vaibhav Mahale and Hiren Patel
    Citation: Stem Cell Research & Therapy 2014 5:106
    Content type: Research Published on:

  37. Osteoporosis is a disease characterized by low bone mineral density (BMD) and increased risk of fractures. Studies have demonstrated the use of phytoestrogens, or plant-derived estrogens, such as genistein and...

    Authors: Amy L Strong, Jason F Ohlstein, Quan Jiang, Qiang Zhang, Shilong Zheng, Stephen M Boue, Steven Elliott, Jeffrey M Gimble, Matthew E Burow, Guangdi Wang and Bruce A Bunnell
    Citation: Stem Cell Research & Therapy 2014 5:105
    Content type: Research Published on:

  38. Mesenchymal stem cells (MSCs) have the ability to repair and regenerate tissue, home to sites of inflammation, and evade the host immune system. As such, they represent an attractive therapy for the treatment ...

    Authors: Catherine B Sullivan, Ryan M Porter, Chris H Evans, Thomas Ritter, Georgina Shaw, Frank Barry and Josephine Mary Murphy
    Citation: Stem Cell Research & Therapy 2014 5:104
    Content type: Research Published on:

  39. The transplantation of genetically modified progenitor cells such as bone marrow-derived mesenchymal stem cells (MSCs) is an attractive strategy to improve the natural healing of articular cartilage defects. I...

    Authors: Janina Frisch, Jagadeesh Kumar Venkatesan, Ana Rey-Rico, Gertrud Schmitt, Henning Madry and Magali Cucchiarini
    Citation: Stem Cell Research & Therapy 2014 5:103
    Content type: Research Published on:

  40. The objective of this work was to evaluate the efficacy of placenta-derived mesenchymal stem cell (MSC) therapy in a mouse model of myocardial infarction (MI). Since MSCs can be obtained from two different reg...

    Authors: Juliana A Passipieri, Tais H Kasai-Brunswick, Grazielle Suhett, Andreza B Martins, Guilherme V Brasil, Dilza B Campos, Nazareth N Rocha, Isalira P Ramos, Debora B Mello, Deivid C Rodrigues, Beatriz B Christie, Bernardo J Silva-Mendes, Alex Balduíno, Renato M Sá, Laudelino M Lopes, Regina C Goldenberg…
    Citation: Stem Cell Research & Therapy 2014 5:102
    Content type: Research Published on:

  41. Studies have shown that stem cells exert their therapeutic effects on acute kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in an endocrine manner, the injection o...

    Authors: Li Xing, Rui Cui, Lei Peng, Jing Ma, Xiao Chen, Ru-Juan Xie and Bing Li
    Citation: Stem Cell Research & Therapy 2014 5:101
    Content type: Research Published on:

  42. Mesenchymal stem cells (MSCs) are an adult stromal cell population possessing potent differentiation capacity and a potential for use across major histocompatibility complex barriers. Although allogeneic MSCs ...

    Authors: Paul Lohan, Cynthia M Coleman, J Mary Murphy, Matthew D Griffin, Thomas Ritter and Aideen E Ryan
    Citation: Stem Cell Research & Therapy 2014 5:99
    Content type: Review Published on:

  43. It has long been established that germline stem cells (GSCs) are responsible for lifelong gametogenesis in males, and some female invertebrates (for example, Drosophila) and lower vertebrates (for example, teleos...

    Authors: Cheryl E Dunlop, Evelyn E Telfer and Richard A Anderson
    Citation: Stem Cell Research & Therapy 2014 5:98
    Content type: Review Published on:

  44. Our previous works demonstrated that systemic orbital fat-derived stem cell (OFSC) transplantation was effective in ameliorating lipopolysaccharide (LPS)-induced extensive acute lung injury (ALI) in vivo mainly t...

    Authors: Gi-Shih Lien, Jen-Fang Liu, Ming-Hsien Chien, Wei-Tse Hsu, Tzu-Hao Chang, Chia-Chi Ku, Andrea Tung-Qian Ji, Peng Tan, Ting-Lieh Hsieh, Liang-Ming Lee and Jennifer H Ho
    Citation: Stem Cell Research & Therapy 2014 5:97
    Content type: Research Published on:

  46. Mesenchymal stromal cells (MSC) are an integral cellular component of the tumor microenvironment. Nevertheless, very little is known about MSC originating from human malignant tissue and modulation of these ce...

    Authors: Benjamin A Kansy, Philip A Dißmann, Hatim Hemeda, Kirsten Bruderek, Anna M Westerkamp, Vivien Jagalski, Patrick Schuler, Katinka Kansy, Stephan Lang, Claudia A Dumitru and Sven Brandau
    Citation: Stem Cell Research & Therapy 2014 5:95
    Content type: Research Published on:

  47. Autologous mesenchymal stem cell (MSC) injection into naturally-occurring equine tendon injuries has been shown to be safe and efficacious and protocols inform translation of the technique into humans. Efficie...

    Authors: Elaine R Garvican, Sandra Cree, Lydia Bull, Roger KW Smith and Jayesh Dudhia
    Citation: Stem Cell Research & Therapy 2014 5:1
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:161

  48. The optimal cell lineage for cardiac-regeneration approaches remains mysterious. Additionally, electrical stimulation promotes cardiomyogenic differentiation of stimulated cells. Therefore, we hypothesized tha...

    Authors: Aida Llucià-Valldeperas, Benjamin Sanchez, Carolina Soler-Botija, Carolina Gálvez-Montón, Santiago Roura, Cristina Prat-Vidal, Isaac Perea-Gil, Javier Rosell-Ferrer, Ramon Bragos and Antoni Bayes-Genis
    Citation: Stem Cell Research & Therapy 2014 5:93
    Content type: Short Report Published on:

  49. Adipose tissue-derived stromal cells (ADSCs) are abundant and easy to obtain, but the diversity of differentiation potential from different locations may vary with the developmental origin of their mesenchymal...

    Authors: Xiaoming Wang, Hui Zhang, Liangming Nie, Linhai Xu, Min Chen and Zhaoping Ding
    Citation: Stem Cell Research & Therapy 2014 5:92
    Content type: Research Published on:

  50. The loss of neurons and degeneration of axons after spinal cord injury result in the loss of sensory and motor functions. A bridging biomaterial construct that allows the axons to grow through has been investi...

    Authors: Bikesh Shrestha, Katherine Coykendall, Yongchao Li, Alex Moon, Priyanka Priyadarshani and Li Yao
    Citation: Stem Cell Research & Therapy 2014 5:91
    Content type: Review Published on:
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Stem Cell Research & Therapy

ISSN: 1757-6512