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  1. Mesenchymal stem cell (MSC) therapy shows great promise for diabetic kidney disease (DKD) patients. Research has been carried out on this topic in recent years. The main goals of this paper are to evaluate the...

    Authors: Wenshan Lin, Hong-Yan Li, Qian Yang, Guangyong Chen, Shujun Lin, Chunling Liao and Tianbiao Zhou
    Citation: Stem Cell Research & Therapy 2021 12:43
    Content type: Research Published on:

  2. Our aim was to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI).

    Authors: Runfeng Zhang, Jiang Yu, Ningkun Zhang, Wensong Li, Jisheng Wang, Guocai Cai, Yu Chen, Yong Yang and Zhenhong Liu
    Citation: Stem Cell Research & Therapy 2021 12:33
    Content type: Research Published on:

  3. A skin flap is one of the most critical surgical techniques for the restoration of cutaneous defects. However, the distal necrosis of the skin flap severely restricts the clinical application of flap surgery. ...

    Authors: Yuan Li, Qi-lin Jiang, Leanne Van der Merwe, Dong-hao Lou and Cai Lin
    Citation: Stem Cell Research & Therapy 2021 12:28
    Content type: Review Published on:

  4. The therapeutic effect of mesenchymal stem cells (MSCs) from human adipose tissue on renal interstitial fibrosis has been demonstrated by several groups. However, the way to enhance the renoprotective effect o...

    Authors: Shulin Li, Yanping Wang, Zhuojun Wang, Lu Chen, Bangjie Zuo, Caixia Liu and Dong Sun
    Citation: Stem Cell Research & Therapy 2021 12:27
    Content type: Research Published on:

  5. Acute liver failure (ALF) is an acute inflammatory liver disease with high mortality. Previous preclinical and clinical trials have confirmed that mesenchymal stem cell (MSC) is a promising therapeutic approac...

    Authors: Jinglin Wang, Yang Liu, Haoran Ding, Xiaolei Shi and Haozhen Ren
    Citation: Stem Cell Research & Therapy 2021 12:15
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2023 14:338

  6. Exosomal microRNAs (miRs) derived from mesenchymal stem cells (MSCs) have been shown to play roles in the pathophysiological processes of sepsis. Moreover, miR-27b is highly enriched in MSC-derived exosomes. H...

    Authors: Jia Sun, Xuan Sun, Junhui Chen, Xin Liao, Yixuan He, Jinsong Wang, Rui Chen, Sean Hu and Chen Qiu
    Citation: Stem Cell Research & Therapy 2021 12:14
    Content type: Research Published on:

  7. Spinal cord injury (SCI) presents a significant challenge for the field of neurotherapeutics. Stem cells have shown promise in replenishing the cells lost to the injury process, but the release of axon growth-...

    Authors: Benjamin Jevans, Nicholas D. James, Emily Burnside, Conor J. McCann, Nikhil Thapar, Elizabeth J. Bradbury and Alan J. Burns
    Citation: Stem Cell Research & Therapy 2021 12:10
    Content type: Research Published on:

  8. Abnormalities in apoptosis, cell cycle, proliferation, and differentiation of human bone marrow mesenchymal stem cells (hBMSCs) significantly impact bone metabolism and remodeling, resulting in various skeleta...

    Authors: Tao Li, Yingxing Xu, Yingzhen Wang and Yaping Jiang
    Citation: Stem Cell Research & Therapy 2021 12:9
    Content type: Research Published on:

  9. Recent developments in adipose-derived stromal/stem cell (ADSC) biology provide new hopes for tissue engineering and regeneration medicine. Due to their pluripotent activity, paracrine activity, and immunomodu...

    Authors: Jun Fang, Feng Chen, Dong Liu, Feiying Gu and Yuezhen Wang
    Citation: Stem Cell Research & Therapy 2021 12:8
    Content type: Review Published on:

  10. The impressive progress in the field of stem cell research in the past decades has provided the ground for the development of cell-based therapy. Mesenchymal stromal cells obtained from adipose tissue (AD-MSCs...

    Authors: Daisy D. Canepa, Elisa A. Casanova, Eirini Arvaniti, Vinko Tosevski, Sonja Märsmann, Benjamin Eggerschwiler, Sascha Halvachizadeh, Johanna Buschmann, André A. Barth, Jan A. Plock, Manfred Claassen, Hans-Christoph Pape and Paolo Cinelli
    Citation: Stem Cell Research & Therapy 2021 12:7
    Content type: Research Published on:

  11. Multipotent progenitor cells have been harvested from different human tissues, including the bone marrow, adipose tissue, and umbilical cord blood. Previously, we identified a population of mesenchymal progeni...

    Authors: Marvin Dingle, Stephen D. Fernicola, Jaira F. de Vasconcellos, Sonia Zicari, Christopher Daniels, John C. Dunn, Alexander Dimtchev and Leon J. Nesti
    Citation: Stem Cell Research & Therapy 2021 12:6
    Content type: Research Published on:

  12. Parkinson’s disease (PD), the second most common neurodegenerative disease worldwide, is caused by the loss of dopaminergic (DAergic) neurons in the substantia nigra resulting in a series of motor or non-motor...

    Authors: Zhuangzhuang Xiao, Tong Lei, Yanyan Liu, Yanjie Yang, Wangyu Bi and Hongwu Du
    Citation: Stem Cell Research & Therapy 2021 12:5
    Content type: Review Published on:

  13. As one of the main functional forms of mesenchymal stem cells (MSCs), MSC-derived extracellular vesicles (MSC-EVs) have shown an alternative therapeutic option in experimental models of allergic asthma. Oxygen...

    Authors: Liyang Dong, Ying Wang, Tingting Zheng, Yanan Pu, Yongbin Ma, Xin Qi, Wenzhe Zhang, Fei Xue, Zirui Shan, Jiameng Liu, Xuefeng Wang and Chaoming Mao
    Citation: Stem Cell Research & Therapy 2021 12:4
    Content type: Research Published on:

  14. Although pancreatic islet transplantation therapy is ideal for diabetes patients, several hurdles have prevented it from becoming a standard treatment, including donor shortage and low engraftment efficacy. In...

    Authors: Yu Na Lee, Hye-Jin Yi, Eun Hye Seo, Jooyun Oh, Song Lee, Sarah Ferber, Teruo Okano, In Kyong Shim and Song Cheol Kim
    Citation: Stem Cell Research & Therapy 2021 12:3
    Content type: Research Published on:

  15. Cerebral infarction ranks as the second leading cause of disability and death globally, and inflammatory response of glial cells is the main cause of brain damage during cerebral infarction.

    Authors: Guofeng Cai, Guoliang Cai, Haichun Zhou, Zhe Zhuang, Kai Liu, Siying Pei, Yanan Wang, Hong Wang, Xin Wang, Shengnan Xu, Cheng Cui, Manchao Sun, Sihui Guo, Kunping Jia, Xiuzhen Wang and Dianquan Zhang
    Citation: Stem Cell Research & Therapy 2021 12:2
    Content type: Research Published on:

  16. Adipose-derived stem cells (ADSCs) have raised big interest in therapeutic applications in regenerative medicine and appear to fulfill the criteria for a successful cell therapy. Their low immunogenicity and t...

    Authors: Loubna Mazini, Mohamed Ezzoubi and Gabriel Malka
    Citation: Stem Cell Research & Therapy 2021 12:1
    Content type: Review Published on:

  17. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Selami Demirci, Juan J. Haro-Mora, Alexis Leonard, Claire Drysdale, Daniela Malide, Keyvan Keyvanfar, Khaled Essawi, Raul Vizcardo, Naritaka Tamaoki, Nicholas P. Restifo, John F. Tisdale and Naoya Uchida
    Citation: Stem Cell Research & Therapy 2020 11:544
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:493

  18. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Behnaz Ashtari, Azar Shams, Narges Esmaeilzadeh, Sara Tanbakooei, Morteza Koruji, Mojtaba Johari Moghadam, Javad Mohajer Ansari, Adel Johari Moghadam and Ronak Shabani
    Citation: Stem Cell Research & Therapy 2020 11:543
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:191

  19. Stem cell transplantation of exogenous neural progenitor cells (NPCs) derived from mesenchymal stem cells (MSCs) has emerged as a promising approach for neurodegenerative disease. Human stem cells from apical ...

    Authors: Anupong Songsaad, Thanasup Gonmanee, Nisarat Ruangsawasdi, Chareerut Phruksaniyom and Charoensri Thonabulsombat
    Citation: Stem Cell Research & Therapy 2020 11:542
    Content type: Research Published on:

  20. Mesenchymal stem cells (MSCs) have exerted their brilliant potential to promote heart repair following myocardial infarction. However, low survival rate of MSCs after transplantation due to harsh conditions wi...

    Authors: Jiaying Fu, Xuxiang Chen, Xin Liu, Daishi Xu, Huan Yang, Chaotao Zeng, Huibao Long, Changqing Zhou, Haidong Wu, Guanghui Zheng, Hao Wu, Wuming Wang and Tong Wang
    Citation: Stem Cell Research & Therapy 2020 11:541
    Content type: Research Published on:

  21. The effects of cryopreservation on human bone marrow-derived mesenchymal stem cells (hBM-MSCs) are still ill-defined. In this study, a quantitative approach was adopted to measure several post-thaw cell attrib...

    Authors: Soukaina Bahsoun, Karen Coopman and Elizabeth C. Akam
    Citation: Stem Cell Research & Therapy 2020 11:540
    Content type: Research Published on:

  22. The paracrine effects of multipotent mesenchymal stromal cells (MSCs) are mediated by their secretome composed by soluble factors (i.e., cytokines, growth factors, hormones) and extracellular vesicles (EVs). E...

    Authors: Anastasia Cheng, Dongsic Choi, Maximilien Lora, Dominique Shum-Tim, Janusz Rak and Inés Colmegna
    Citation: Stem Cell Research & Therapy 2020 11:539
    Content type: Research Published on:

  23. Arteriosclerosis is an age-related disease and a leading cause of cardiovascular disease. In animal experiments, mesenchymal stem cells and its culture-conditioned medium have been shown to be promising tools ...

    Authors: Hiroki Ohta, Xiaolan Liu and Miho Maeda
    Citation: Stem Cell Research & Therapy 2020 11:538
    Content type: Research Published on:

  24. The role of bone tissue engineering is to regenerate tissue using biomaterials and stem cell-based approaches. Combination of two or more cell types is one of the strategies to promote bone formation. Endothel...

    Authors: Chu Xu, Haijie Liu, Yuanjia He, Yuanqing Li and Xiaoning He
    Citation: Stem Cell Research & Therapy 2020 11:537
    Content type: Research Published on:

  25. Skeletal muscle is a complex and heterogeneous tissue accounting for approximately 40% of body weight. Excessive ectopic lipid accumulation in the muscle fascicle would undermine the integrity of skeletal musc...

    Authors: Xin Zhang, Wenjuan Sun, Linjuan He, Liqi Wang, Kai Qiu and Jingdong Yin
    Citation: Stem Cell Research & Therapy 2020 11:536
    Content type: Research Published on:

  26. Tissue engineering is a promising alternative for urethral reconstruction, and adipose-derived stem cells (ADSCs) are widely used as seeding cells. Hypoxia preconditioning can significantly enhance the therape...

    Authors: Xiang Wan, Min-kai Xie, Huan Xu, Zi-wei Wei, Hai-jun Yao, Zhong Wang and Da-chao Zheng
    Citation: Stem Cell Research & Therapy 2020 11:535
    Content type: Research Published on:

  27. Mesenchymal stem/stromal cells can modulate the effector immune cells especially T lymphocytes. Due to this important feature, they can regulate the development of a variety of disorders including inflammatory...

    Authors: Sina Naserian, Sara Shamdani, Nassim Arouche and Georges Uzan
    Citation: Stem Cell Research & Therapy 2020 11:534
    Content type: Short report Published on:

  28. Biological composite scaffolds are increasingly being used in abdominal wall reconstruction but still have certain shortcomings. The present study describes here a novel three-dimensional (3D) scaffold fabrica...

    Authors: Zhi Yang, Zhicheng Song, Xin Nie, Kaijin Guo and Yan Gu
    Citation: Stem Cell Research & Therapy 2020 11:533
    Content type: Research Published on:

  29. Human mesenchymal stromal cells (MSC) hold hopes for cartilage regenerative therapy due to their chondrogenic differentiation potential. However, undesirable occurrence of calcification after ectopic transplan...

    Authors: Svitlana Melnik, Jessica Gabler, Simon I. Dreher, Nicole Hecht, Nina Hofmann, Tobias Großner and Wiltrud Richter
    Citation: Stem Cell Research & Therapy 2020 11:532
    Content type: Research Published on:

  30. Human dental pulp stromal cells (hDPSCs) are promising sources of mesenchymal stem cells (MSCs) for bone tissue regeneration. Circular RNAs (circRNAs) have been demonstrated to play critical roles in stem cell...

    Authors: Bo Zhang, Sibei Huo, Xiao Cen, Xuefeng Pan, Xinqi Huang and Zhihe Zhao
    Citation: Stem Cell Research & Therapy 2020 11:531
    Content type: Research Published on:

  31. Chronic kidney disease (CKD) is a global public health problem. Cell therapy using pluripotent stem cells represents an attractive therapeutic approach for the treatment of CKD.

    Authors: Patrícia de Carvalho Ribeiro, Fernando Henrique Lojudice, Ida Maria Maximina Fernandes-Charpiot, Maria Alice Sperto Ferreira Baptista, Stanley de Almeida Araújo, Gloria Elisa Florido Mendes, Mari Cleide Sogayar, Mario Abbud-Filho and Heloisa Cristina Caldas
    Citation: Stem Cell Research & Therapy 2020 11:530
    Content type: Research Published on:

  32. During development, excessive osteogenic differentiation of mesenchymal progenitor cells (MPC) within the cranial sutures can lead to premature suture fusion or craniosynostosis, leading to craniofacial and co...

    Authors: Clara Pribadi, Esther Camp, Dimitrios Cakouros, Peter Anderson, Carlotta Glackin and Stan Gronthos
    Citation: Stem Cell Research & Therapy 2020 11:529
    Content type: Research Published on:

  33. Ectopic expression of a defined set of transcription factors allows the reprogramming of mammalian somatic cells to pluripotency. Despite continuous progress in primate and rodent reprogramming, limited attent...

    Authors: Ian C. Tobias, Mian-Mian C. Kao, Thomas Parmentier, Hailey Hunter, Jonathan LaMarre and Dean H. Betts
    Citation: Stem Cell Research & Therapy 2020 11:528
    Content type: Research Published on:

  34. The transplantation of human umbilical cord blood (UCB) CD34+ cells has been successfully used to treat hematological disorders but one major limitation has been the low cell numbers available. Mesenchymal ste...

    Authors: Hao Daniel Lin, Chui-Yee Fong, Arijit Biswas and Ariff Bongso
    Citation: Stem Cell Research & Therapy 2020 11:527
    Content type: Research Published on:

  35. Bone marrow mesenchymal stem cell (BM-MSC) has been shown to treat pulmonary arterial hypertension (PAH). However, excessive reactive oxygen species (ROS) increases the apoptosis of BM-MSCs, leading to poor su...

    Authors: Qian Zhang, Xianfeng Cheng, Haizhou Zhang, Tao Zhang, Zhengjun Wang, Wenlong Zhang and Wancheng Yu
    Citation: Stem Cell Research & Therapy 2020 11:526
    Content type: Research Published on:

  36. Mesenchymal stem cells (MSCs) were shown to harbor therapeutic potential in models of respiratory diseases, such as bronchopulmonary dysplasia (BPD), the most common sequel of preterm birth. In these studies, ...

    Authors: Janine Obendorf, Claire Fabian, Ulrich H. Thome and Mandy Laube
    Citation: Stem Cell Research & Therapy 2020 11:525
    Content type: Research Published on:

  37. The efficacy of mesenchymal stromal cell (MSC) therapy is thought to depend on the intrinsic heterogeneity of MSC cultures isolated from different tissue sources as well as individual MSCs isolated from the sa...

    Authors: Rebecca M. Harman, Roosheel S. Patel, Jennifer C. Fan, Jee E. Park, Brad R. Rosenberg and Gerlinde R. Van de Walle
    Citation: Stem Cell Research & Therapy 2020 11:524
    Content type: Research Published on:

  38. The corneal endothelium located on the posterior corneal surface is responsible for regulating stromal hydration. This is contributed by a monolayer of corneal endothelial cells (CECs), which are metabolically...

    Authors: Nicole Ming Sie, Gary Hin-Fai Yam, Yu Qiang Soh, Matthew Lovatt, Deepinder Dhaliwal, Viridiana Kocaba and Jodhbir S. Mehta
    Citation: Stem Cell Research & Therapy 2020 11:523
    Content type: Review Published on:

  39. The physical factors of the extracellular matrix have a profound influence on the differentiation behavior of mesenchymal stem cells. In this study, the effect of the biophysical microenvironment on rat bone m...

    Authors: Yuchao Yang, Yanting Feng, Rongmei Qu, Qingtao Li, Dongming Rong, Tingyu Fan, Yiting Yang, Bing Sun, Zhenyu Bi, Asmat Ullah Khan, Ting Deng, Jingxing Dai and Jun Ouyang
    Citation: Stem Cell Research & Therapy 2020 11:522
    Content type: Research Published on:

  40. In the last years, several clinical trials have proved the safety and efficacy of adipose-derived stem/stromal cells (ASC) in contrasting osteoarthritis (OA). Since ASC act mainly through paracrine mechanisms,...

    Authors: Chiara Giannasi, Stefania Niada, Cinzia Magagnotti, Enrico Ragni, Annapaola Andolfo and Anna Teresa Brini
    Citation: Stem Cell Research & Therapy 2020 11:521
    Content type: Research Published on:

  41. Accumulating evidence indicates that mesenchymal stem cells (MSCs) exert tissue repair effects and therapeutic angiogenesis through their noncoding RNAs (ncRNAs). Our previous studies showed that MSCs derived ...

    Authors: Qin Shi, Baolan Sun, Di Wang, Yi Zhu, Xinxin Zhao, Xiaoqing Yang and Yuquan Zhang
    Citation: Stem Cell Research & Therapy 2020 11:520
    Content type: Research Published on:

  42. Human umbilical cord mesenchymal stem cells (HUC-MSCs) present in the umbilical cord tissue are self-renewing and multipotent. They can renew themselves continuously and, under certain conditions, differentiat...

    Authors: Qixin Xie, Rui Liu, Jia Jiang, Jing Peng, Chunyan Yang, Wen Zhang, Sheng Wang and Jing Song
    Citation: Stem Cell Research & Therapy 2020 11:519
    Content type: Review Published on:

  44. To investigate the odonto-immunomodulatory properties of dental pulp stem cell-derived small extracellular vesicles (DPSCs-sEV), which promote odontogenesis by switching macrophages toward the pro-healing M2 p...

    Authors: Jianmao Zheng, Yuanyuan Kong, Xiaoli Hu, Zhishan Li, Yaoyin Li, Yingqun Zhong, Xi Wei and Junqi Ling
    Citation: Stem Cell Research & Therapy 2020 11:517
    Content type: Research Published on:

  45. Bone destruction is a hallmark of multiple myeloma (MM). It has been reported that proteasome inhibitors (PIs) can reduce bone resorption and increase bone formation in MM patients, but the underlying mechanis...

    Authors: Dan Zhang, Kim De Veirman, Rong Fan, Qiang Jian, Yuchen Zhang, Li Lei, Holly Evans, Yanmeng Wang, Lei Lei, Baiyan Wang, Ramone A. Williamson, Andrew Chantry, Pengcheng He, Ang Li, Hendrik De Raeve, Karin Vanderkerken…
    Citation: Stem Cell Research & Therapy 2020 11:516
    Content type: Research Published on:

  47. Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global pandemic. The prevalence/severity of COVID-19 is higher among patients with cardiovasc...

    Authors: Youjeong Kwon, Sarath Babu Nukala, Shubhi Srivastava, Hiroe Miyamoto, Nur Izzah Ismail, Jordan Jousma, Jalees Rehman, Sang-Bing Ong, Won Hee Lee and Sang-Ging Ong
    Citation: Stem Cell Research & Therapy 2020 11:514
    Content type: Letter Published on:

  48. The present study compared the effects of antifibrotic medications, pirfenidone, and nintedanib, with transplantation of human umbilical mesenchymal stem cells (HUMSCs) in restoring rat pulmonary fibrosis (PF).

    Authors: Kuo-An Chu, Chang-Ching Yeh, Fu-Hsien Kuo, Wen-Ren Lin, Chien-Wei Hsu, Tien-Hua Chen and Yu-Show Fu
    Citation: Stem Cell Research & Therapy 2020 11:513
    Content type: Research Published on:

  49. Mesenchymal stem cell (MSC)-derived exosomes have shown comprehensive application prospects over the years. Despite performing similar functions, exosomes from different origins present heterogeneous character...

    Authors: Zheng-gang Wang, Zhi-yi He, Shuang Liang, Qing Yang, Peng Cheng and An-min Chen
    Citation: Stem Cell Research & Therapy 2020 11:511
    Content type: Research Published on:

  50. De novo mutations (DNMs) have been implicated in the etiology of schizophrenia (SZ), a chronic debilitating psychiatric disorder characterized by hallucinations, delusions, cognitive dysfunction, and decreased...

    Authors: Edit Hathy, Eszter Szabó, Nóra Varga, Zsuzsa Erdei, Csongor Tordai, Boróka Czehlár, Máté Baradits, Bálint Jezsó, Júlia Koller, László Nagy, Mária Judit Molnár, László Homolya, Zsófia Nemoda, Ágota Apáti and János M. Réthelyi
    Citation: Stem Cell Research & Therapy 2020 11:504
    Content type: Research Published on:
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