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  1. Recent studies have suggested that the regulation of endogenous neural stem cells (NSCs) or transplanting of exogenous nerve cells are the newest and most promising methods for the treatment of dementia and ot...

    Authors: Chao Ren, Peiyuan Yin, Neng Ren, Zhe Wang, Jiahui Wang, Caiyi Zhang, Wei Ge, Deqin Geng and Xiaotong Wang
    Citation: Stem Cell Research & Therapy 2018 9:66
    Content type: Review Published on:

  2. Mesenchymal stem cells (MSCs) are a reliable resource for bone regeneration and tissue engineering, but the molecular mechanisms of differentiation remain unclear. The tumor antigen 15-leucine-rich repeat cont...

    Authors: Yuejun Wang, Yunsong Liu, Min Zhang, Longwei Lv, Xiao Zhang, Ping Zhang and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2018 9:65
    Content type: Research Published on:

  3. Mesenchymal stem cells (MSCs) are multipotent stem cells that have gained significant attention in the field of regenerative medicine. The differentiation potential along with paracrine properties of MSCs have...

    Authors: Somayeh Keshtkar, Negar Azarpira and Mohammad Hossein Ghahremani
    Citation: Stem Cell Research & Therapy 2018 9:63
    Content type: Review Published on:

  4. Mesenchymal stem cells derived from gingiva (GMSCs) display profound immunomodulation properties in addition to self-renewal and multilineage differentiation capacities. Hydrogen sulfide (H2S) is not only an envi...

    Authors: Ruili Yang, Tingting Yu, Dawei Liu, Songtao Shi and Yanheng Zhou
    Citation: Stem Cell Research & Therapy 2018 9:62
    Content type: Research Published on:

  5. Intervertebral disc (IVD) degeneration is characterized by an early decrease in cellularity of the nucleus pulposus (NP) region, and associated extracellular matrix changes, reduced hydration, and progressive ...

    Authors: Ruhang Tang, Liufang Jing, Vincent P. Willard, Chia-lung Wu, Farshid Guilak, Jun Chen and Lori A. Setton
    Citation: Stem Cell Research & Therapy 2018 9:61
    Content type: Research Published on:

  6. Use of bioscaffolds to direct osteogenic differentiation of adult multipotent stromal cells (MSCs) without exogenous proteins is a contemporary approach to bone regeneration. Identification of in vivo osteogen...

    Authors: Wei Duan, Cong Chen, Masudul Haque, Daniel Hayes and Mandi J. Lopez
    Citation: Stem Cell Research & Therapy 2018 9:60
    Content type: Research Published on:

  7. The advent of human-induced pluripotent stem cells holds great promise for producing ample individualized hepatocytes. Although previous efforts have succeeded in generating hepatocytes from human pluripotent ...

    Authors: Cong Du, Yuan Feng, Dongbo Qiu, Yan Xu, Mao Pang, Nan Cai, Andy Peng Xiang and Qi Zhang
    Citation: Stem Cell Research & Therapy 2018 9:58
    Content type: Research Published on:

  8. The reciprocal fate decision of mesenchymal stem cells (MSCs) to either bone or adipocytes is determined by Wnt-related signaling and the glucagon-like peptide-1 receptor (GLP-1R). Azoramide, an ER stress alle...

    Authors: Banjun Ruan, Zheng Zhu, Zhao Yan, Wei Yang, Dongsheng Zhai, Li Wang, Zichen Ye, Huanyu Lu, An Xiang, Jingwei Liang, Yinghao Jiang, Chengming Xu, Zhenyu Wang, Ming Wei, Xiaoying Lei, Xiaorui Cao…
    Citation: Stem Cell Research & Therapy 2018 9:57
    Content type: Research Published on:

  9. Although many reports show that various kinds of stem cells have the ability to recover function in premature ovarian aging, few studies have looked at stem cell treatment of natural ovarian aging (NOA). We de...

    Authors: Chenyue Ding, Qinyan Zou, Fuxin Wang, Huihua Wu, Rulei Chen, Jinghuan Lv, Mingfa Ling, Jian Sun, Wei Wang, Hong Li and Boxian Huang
    Citation: Stem Cell Research & Therapy 2018 9:55
    Content type: Research Published on:

  10. Shockwaves and mesenchymal stem cells (MSCs) have been widely accepted as useful tools for many orthopedic applications. However, the modulatory effects of shockwaves on MSCs remain controversial. In this stud...

    Authors: Hao Zhang, Zhong-Li Li, Fei Yang, Qiang Zhang, Xiang-Zheng Su, Ji Li, Ning Zhang, Chun-Hui Liu, Ning Mao and Heng Zhu
    Citation: Stem Cell Research & Therapy 2018 9:54
    Content type: Research Published on:

  11. Adipose-derived stem cells (ADSCs) are an attractive cell source for bone tissue engineering and have great potential for bone regeneration and defect repair. The transcriptional coactivator with PDZ-binding m...

    Authors: Yumin Zhu, Yaping Wu, Jie Cheng, Qiong Wang, Zhongwu Li, Yanling Wang, Dongmiao Wang, Hua Wang, Weibing Zhang, Jinhai Ye, Hongbing Jiang and Lin Wang
    Citation: Stem Cell Research & Therapy 2018 9:53
    Content type: Research Published on:

  12. Human mesenchymal stem cell (hMSC) differentiation into osteoblasts has important clinical significance in treating bone injury, and the stiffness of the extracellular matrix (ECM) has been shown to be an impo...

    Authors: Meiyu Sun, Guangfan Chi, Juanjuan Xu, Ye Tan, Jiayi Xu, Shuang Lv, Ziran Xu, Yuhan Xia, Lisha Li and Yulin Li
    Citation: Stem Cell Research & Therapy 2018 9:52
    Content type: Research Published on:

  13. The LIM-homeobox transcription factor islet-1 (ISL1) has been proposed as a marker for cardiovascular progenitor cells. This study investigated whether forced expression of ISL1 in human mesenchymal stem cells...

    Authors: Qiuling Xiang, Yan Liao, Hua Chao, Weijun Huang, Jia Liu, Haixuan Chen, Dongxi Hong, Zhengwei Zou, Andy Peng Xiang and Weiqiang Li
    Citation: Stem Cell Research & Therapy 2018 9:51
    Content type: Research Published on:

  14. Asherman’s syndrome (AS) is one of the gynecological disorders caused by the destruction of the endometrium. For some cases of AS available surgical methods and hormonal therapy are ineffective. Stem cell tran...

    Authors: Alisa Domnina, Polina Novikova, Julia Obidina, Irina Fridlyanskaya, Larisa Alekseenko, Irina Kozhukharova, Olga Lyublinskaya, Valeriy Zenin and Nikolay Nikolsky
    Citation: Stem Cell Research & Therapy 2018 9:50
    Content type: Research Published on:

  15. Induced pluripotent stem cells (iPS) represent an innovative source for the standardized in vitro generation of macrophages (Mφ). Mφ show great promise in disease pathogenesis, particularly tuberculosis. However,...

    Authors: Danping Hong, Jiongyan Ding, Ouyang Li, Quan He, Minxia Ke, Mengyi Zhu, Lili Liu, Wen-Bin Ou, Yulong He and Yuehong Wu
    Citation: Stem Cell Research & Therapy 2018 9:49
    Content type: Research Published on:

  16. Human menstrual blood-derived stromal cells (MenSCs) are highly proliferative and show multiple differentiation capacity. The convenience and non-invasiveness make MenSC a novel cell source for regenerative me...

    Authors: Siwen Zhang, Pingping Li, Zhengwei Yuan and Jichun Tan
    Citation: Stem Cell Research & Therapy 2018 9:48
    Content type: Research Published on:

  17. Changes in metabolic pathway preferences are key events in the reprogramming process of somatic cells to induced pluripotent stem cells (iPSCs). The optimization of metabolic conditions can enhance reprogrammi...

    Authors: Zhaoyu Lin, Fei Liu, Peiliang Shi, Anying Song, Zan Huang, Dayuan Zou, Qin Chen, Jianxin Li and Xiang Gao
    Citation: Stem Cell Research & Therapy 2018 9:47
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:111

  18. Thalassemia is the most common genetic disease worldwide; those with severe disease require lifelong blood transfusion and iron chelation therapy. The definitive cure for thalassemia is allogeneic hematopoieti...

    Authors: Methichit Wattanapanitch, Nattaya Damkham, Ponthip Potirat, Kongtana Trakarnsanga, Montira Janan, Yaowalak U-pratya, Pakpoom Kheolamai, Nuttha Klincumhom and Surapol Issaragrisil
    Citation: Stem Cell Research & Therapy 2018 9:46
    Content type: Research Published on:

  19. Due to their anti-inflammatory, antiapoptotic, antimicrobial, and antifibrotic properties, mesenchymal stromal cells (MSCs) have been considered a promising alternative for treatment of respiratory diseases. N...

    Authors: Luisa H. A. Silva, Mariana A. Antunes, Claudia C. Dos Santos, Daniel J. Weiss, Fernanda F. Cruz and Patricia R. M. Rocco
    Citation: Stem Cell Research & Therapy 2018 9:45
    Content type: Review Published on:

  20. In the past years, cardiac mortality has decreased, but cardiac diseases are still responsible for millions of deaths every year worldwide. Bone-marrow mesenchymal stem cells (BMSCs) transplantation may be a p...

    Authors: Xiaofei Guo, Yan Bai, Li Zhang, Bo Zhang, Naufal Zagidullin, Katherine Carvalho, Zhimin Du and Benzhi Cai
    Citation: Stem Cell Research & Therapy 2018 9:44
    Content type: Review Published on:

  21. For patients with thromboangiitis obliterans (TAO), revascularization with bypass or angioplasty is frequently not feasible due to the poor outflow of the distal small vessels. We evaluated the long-term resul...

    Authors: Jianming Guo, Lianrui Guo, Shijun Cui, Zhu Tong, Alan Dardik and Yongquan Gu
    Citation: Stem Cell Research & Therapy 2018 9:43
    Content type: Research Published on:

  22. Chondrogenic mesenchymal stem cells (MSCs) have not yet been used to address the clinical demands of large osteochondral joint surface defects. In this study, self-assembling tissue intermediates (TIs) derived...

    Authors: L. F. Mendes, H. Katagiri, W. L. Tam, Y. C. Chai, L. Geris, S. J. Roberts and F. P. Luyten
    Citation: Stem Cell Research & Therapy 2018 9:42
    Content type: Research Published on:

  23. C-kit-positive cardiac stem cells (CSCs) have been shown to be a promising candidate treatment for myocardial infarction and heart failure. Insulin-like growth factor (IGF)-1 is an anabolic growth hormone that...

    Authors: Yuning Sun, Rongfeng Xu, Jia Huang, Yuyu Yao, Xiaodong Pan, Zhongpu Chen and Genshan Ma
    Citation: Stem Cell Research & Therapy 2018 9:41
    Content type: Research Published on:

  25. Numerous stem cell therapies use injection-based administration to deliver high-density cell preparations. However, cell retention rates as low as 1% have been observed within days of transplantation. This stu...

    Authors: Mahetab H. Amer, Felicity R. A. J. Rose, Kevin M. Shakesheff and Lisa J. White
    Citation: Stem Cell Research & Therapy 2018 9:39
    Content type: Research Published on:

  26. Wharton's jelly cells (WJCs) have multiple differentiation potentials and are easily harvested in large numbers. WJCs are well tolerated in allogeneic environments and there is a growing list of their therapeu...

    Authors: Kreeson Packthongsuk, Theresa Rathbun, Deryl Troyer and Duane L. Davis
    Citation: Stem Cell Research & Therapy 2018 9:38
    Content type: Research Published on:

  27. Human placenta-derived mesenchymal stem cell (hPMSC) transplantation has been demonstrated to be an effective way of recovering ovarian function in mice with autoimmune induced premature ovarian failure (POF)....

    Authors: Na Yin, Yanlin Wang, Xueyan Lu, Ranran Liu, Lianshuang Zhang, Wei Zhao, Wendan Yuan, Qianqian Luo, Hao Wu, Xiying Luan and Hongqin Zhang
    Citation: Stem Cell Research & Therapy 2018 9:37
    Content type: Research Published on:

  28. Repair deficiency after endometrial injury is an important reason for intra-uterine adhesions, amenorrhea, and infertility in females. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is effect...

    Authors: Lu Zhang, Ying Li, Chun-Yi Guan, Shi Tian, Xiao-Dan Lv, Jian-Hui Li, Xu Ma and Hong-Fei Xia
    Citation: Stem Cell Research & Therapy 2018 9:36
    Content type: Research Published on:

  29. Co-cultures of endothelial cells with mesenchymal stem cells currently represent one of the most promising approaches in providing oxygen and nutrient supply for microvascular tissue engineering. Still, to tra...

    Authors: Severin Mühleder, Karoline Pill, Mira Schaupper, Krystyna Labuda, Eleni Priglinger, Pablo Hofbauer, Verena Charwat, Uwe Marx, Heinz Redl and Wolfgang Holnthoner
    Citation: Stem Cell Research & Therapy 2018 9:35
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:261

  30. CXCR4 was the first receptor identified for CXCL12, but a second receptor, CXCR7, has also been described and its function in hematopoietic cells remains unknown. By inhibition of CXCR4 and/or CXCR7, we showed...

    Authors: Rita de Cassia Carvalho Melo, Karla Priscila Viera Ferro, Adriana da Silva Santos Duarte and Sara Teresinha Olalla Saad
    Citation: Stem Cell Research & Therapy 2018 9:34
    Content type: Letter Published on:

  32. Several studies have focused on umbilical cord-derived mesenchymal stem cells (UC-MSCs) due to their potential therapeutic effects in a cluster of diseases. However, there has been no bibliometric analysis eva...

    Authors: Jian Zhao, Guanyu Yu, Mengxi Cai, Xiao Lei, Yanyong Yang, Qijin Wang and Xiao Zhai
    Citation: Stem Cell Research & Therapy 2018 9:32
    Content type: Review Published on:

  33. Mesenchymal stromal cells (MSCs) are an attractive therapeutic agent in regenerative medicine. Recently, there has been a paradigm shift from differentiation of MSCs to their paracrine effects at the injury si...

    Authors: Apeksha Damania, Deepika Jaiman, Arun Kumar Teotia and Ashok Kumar
    Citation: Stem Cell Research & Therapy 2018 9:31
    Content type: Research Published on:

  34. Doxorubicin (Dox) is a chemotherapy drug with limited application due to cardiotoxicity that may progress to heart failure. This study aims to evaluate the role of cardiomyocytes derived from mouse embryonic s...

    Authors: Danúbia Silva dos Santos, Guilherme Visconde Brasil, Isalira Peroba Rezende Ramos, Fernanda Cristina Paccola Mesquita, Tais Hanae Kasai-Brunswick, Michelle Lopes Araújo Christie, Gustavo Monnerat Cahli, Raiana Andrade Quintanilha Barbosa, Sandro Torrentes da Cunha, Jonathas Xavier Pereira, Emiliano Medei, Antonio Carlos Campos de Carvalho, Adriana Bastos Carvalho and Regina Coeli dos Santos Goldenberg
    Citation: Stem Cell Research & Therapy 2018 9:30
    Content type: Research Published on:

  35. Mature human hepatocytes are critical in preclinical research and therapy for liver disease, but are difficult to manipulate and expand in vitro. Hepatic stem cells (HpSCs) may be an alternative source of func...

    Authors: Ran-Ran Zhang, Yun-Wen Zheng, Bin Li, Yun-Zhong Nie, Yasuharu Ueno, Tomonori Tsuchida and Hideki Taniguchi
    Citation: Stem Cell Research & Therapy 2018 9:29
    Content type: Research Published on:

  36. Studies in which mesenchymal stromal cells (MSC) from the placenta are compared with multiple MSC types from other sources are rare. The chorionic plate of the human placenta is mainly composed of fetal blood ...

    Authors: Mónica S. Ventura Ferreira, Michaela Bienert, Katrin Müller, Björn Rath, Tamme Goecke, Christian Opländer, Till Braunschweig, Petra Mela, Tim H. Brümmendorf, Fabian Beier and Sabine Neuss
    Citation: Stem Cell Research & Therapy 2018 9:28
    Content type: Research Published on:

  37. The study aimed to evaluate the efficacy and safety of gingival mesenchymal stem cells (GMSCs) from human fetal gingival tissue used for treating gingival defects in a rat model.

    Authors: Jing Li, Shi-qing Xu, Kai Zhang, Wen-jian Zhang, Hong-lin Liu, Zhen Xu, Hong Li, Jin-ning Lou, Li-hong Ge and Bao-hua Xu
    Citation: Stem Cell Research & Therapy 2018 9:27
    Content type: Research Published on:

  38. Currently, ex-vivo handling of stem cells, including transport after harvest and therapeutic preparation, is generally done in culture media containing fetal bovine serum (FBS), which promotes cell attachment,...

    Authors: Mai Mochizuki and Taka Nakahara
    Citation: Stem Cell Research & Therapy 2018 9:25
    Content type: Research Published on:

  39. Radiation-induced gastrointestinal syndrome (RIGS) results from the acute loss of intestinal stem cells (ISC), impaired epithelial regeneration, and subsequent loss of the mucosal barrier, resulting in electro...

    Authors: Payel Bhanja, Andrew Norris, Pooja Gupta-Saraf, Andrew Hoover and Subhrajit Saha
    Citation: Stem Cell Research & Therapy 2018 9:26
    Content type: Research Published on:

  40. Human dental pulp stem cells (DPSCs), which have the ability to differentiate into multiple lineages, were recently identified. DPSCs can be collected readily from extracted teeth and are now considered to be ...

    Authors: Yasuyuki Fujii, Yoko Kawase-Koga, Hironori Hojo, Fumiko Yano, Marika Sato, Ung-il Chung, Shinsuke Ohba and Daichi Chikazu
    Citation: Stem Cell Research & Therapy 2018 9:24
    Content type: Research Published on:

  41. In bone tissue engineering (BTE), extensive research into vascular endothelial growth factor A (VEGFA)-mediated angiogenesis has yielded inconsistent results. The aim of this study was to investigate the influ...

    Authors: Sunita Sharma, Dipak Sapkota, Ying Xue, Saroj Rajthala, Mohammed A. Yassin, Anna Finne-Wistrand and Kamal Mustafa
    Citation: Stem Cell Research & Therapy 2018 9:23
    Content type: Research Published on:

  42. During tumorigenesis and development, participation of the tumor microenvironment is not negligible. As an important component in the tumor microenvironment, mesenchymal stem cells (MSCs) have been corroborate...

    Authors: Ying Zheng, Gangyang Wang, Ruiling Chen, Yingqi Hua and Zhengdong Cai
    Citation: Stem Cell Research & Therapy 2018 9:22
    Content type: Review Published on:

  43. Adult full-thickness cutaneous wound repair suffers from an imbalanced immune response, leading to nonfunctional reconstructed tissue and fibrosis. Although various treatments have been reported, the immune-me...

    Authors: Zhi Yang, Chengmin He, Jinyang He, Jing Chu, Hanping Liu and Xiaoyuan Deng
    Citation: Stem Cell Research & Therapy 2018 9:21
    Content type: Research Published on:

  44. This study was performed to determine the effects of human placenta mesenchymal stem cell (hPMSC) transplantation on granulosa cell apoptosis and anti-Müllerian hormone (AMH) and follicle-stimulating hormone r...

    Authors: Hongqin Zhang, Qianqian Luo, Xueyan Lu, Na Yin, Dongli Zhou, Lianshuang Zhang, Wei Zhao, Dong Wang, Pengchao Du, Yun Hou, Yan Zhang and Wendan Yuan
    Citation: Stem Cell Research & Therapy 2018 9:20
    Content type: Research Published on:

  45. The underlying pathophysiology in intellectual disability (ID) involves abnormalities in dendritic branching and connectivity of the neuronal network. This limits the ability of the brain to process informatio...

    Authors: Alok Sharma, Hemangi Sane, Nandini Gokulchandran, Suhasini Pai, Pooja Kulkarni, Vaishali Ganwir, Maitree Maheshwari, Ridhima Sharma, Meenakshi Raichur, Samson Nivins and Prerna Badhe
    Citation: Stem Cell Research & Therapy 2018 9:19
    Content type: Research Published on:

  46. Since radiotherapy is widely used in managing thoracic tumors, physicians have begun to realize that radiation-induced lung injury (RILI) seriously limits the effects of radiotherapy. Unfortunately, there are ...

    Authors: Tiankai Xu, Yuyu Zhang, Pengyu Chang, Shouliang Gong, Lihong Shao and Lihua Dong
    Citation: Stem Cell Research & Therapy 2018 9:18
    Content type: Review Published on:

  47. Mesenchymal stem (stromal) cells (MSCs) mediate their immunoregulatory and tissue repair functions by secreting paracrine factors, including extracellular vesicles (EVs). In several animal models of human dise...

    Authors: Mahesh Khatri, Levi Arthur Richardson and Tea Meulia
    Citation: Stem Cell Research & Therapy 2018 9:17
    Content type: Research Published on:

  48. Deciphering molecular mechanisms underlying the division of hematopoietic stem cells (HSCs) and malignant precursors would improve our understanding of the basis of stem cell-fate decisions and oncogenic trans...

    Authors: Yuchen Wang, Hong Tian, Wenzhi Cai, Zhaorui Lian, Dheeraj Bhavanasi, Chao Wu, Tomohiko Sato, Mineo Kurokawa, Depei Wu, Li Fu, Hong Wang, Hao Shen, Dong Liang and Jian Huang
    Citation: Stem Cell Research & Therapy 2018 9:16
    Content type: Research Published on:

  49. Pancreatic progenitors (PPs) co-expressing the two transcription factors (TFs) PDX1 and NKX6.1 are recognized as the indispensable precursors of functional pancreatic β cells. Here, we aimed to establish an ef...

    Authors: Bushra Memon, Manale Karam, Sara Al-Khawaga and Essam M. Abdelalim
    Citation: Stem Cell Research & Therapy 2018 9:15
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:262

  50. Interleukin-6 (IL-6) with IL-6 receptor (IL-6R) play an important role in the tissue regeneration in vivo, especially bone metabolism. Bone marrow -derived mesenchymal stem cells (BM-MSCs) are multipotent stro...

    Authors: Zhongyu Xie, Su’an Tang, Guiwen Ye, Peng Wang, Jinteng Li, Wenjie Liu, Ming Li, Shan Wang, Xiaohua Wu, Shuizhong Cen, Guan Zheng, Mengjun Ma, Yanfeng Wu and Huiyong Shen
    Citation: Stem Cell Research & Therapy 2018 9:13
    Content type: Research Published on:
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ISSN: 1757-6512