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  1. Local ischemia and defective osteogenesis are implicated in the progression of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH). Recent studies have revealed that exosomes released from adi...

    Authors: Kai Nan, Yuankai Zhang, Xin Zhang, Dong Li, Yan Zhao, Zhaopu Jing, Kang Liu, Donglong Shang, Zilong Geng and Lihong Fan

    Citation: Stem Cell Research & Therapy 2021 12:331

    Content type: Research

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  2. Co-transplantation of bone marrow cells (BMCs) and mesenchymal stem cells (MSCs) is used as a strategy to improve the outcomes of bone marrow transplantation. Tonsil-derived MSCs (TMSCs) are a promising source...

    Authors: Hyun-Ji Lee, Yu-Hee Kim, Da-Won Choi, Kyung-Ah Cho, Joo-Won Park, Sang-Jin Shin, Inho Jo, So-Youn Woo and Kyung-Ha Ryu

    Citation: Stem Cell Research & Therapy 2021 12:329

    Content type: Research

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  3. Bone marrow-derived mesenchymal stem cells (BM-MSCs) have shown therapeutic potential in various in vitro and in vivo studies in cutaneous wound healing. Furthermore, there are ubiquitous studies highlighting ...

    Authors: Jeffrey D. McBride, Luis Rodriguez-Menocal, Wellington Guzman, Aisha Khan, Ciara Myer, Xiaochen Liu, Sanjoy K. Bhattacharya and Evangelos V. Badiavas

    Citation: Stem Cell Research & Therapy 2021 12:328

    Content type: Research

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  4. Systemic sclerosis (SSc) is a disease that features severe fibrosis of the skin and lacks effective therapy. Bone marrow mesenchymal stem cell (BMSC)-derived extracellular vesicles (EVs) are potential stem cel...

    Authors: Jiahui Jin, Qingjian Ou, Zhe Wang, Haibin Tian, Jing-Ying Xu, Furong Gao, Shuqin Hu, Jie Chen, Juan Wang, Jieping Zhang, Lixia Lu, Caixia Jin, Guo-Tong Xu and Jingjun Zhao

    Citation: Stem Cell Research & Therapy 2021 12:327

    Content type: Research

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  5. Methylsulfonylmethane (MSM) is a nutraceutical compound which has been indicated to counteract osteoarthritis, a cartilage degenerative disorder. In addition, MSM has also been shown to increase osteoblast dif...

    Authors: Luca Dalle Carbonare, Jessica Bertacco, Giulia Marchetto, Samuele Cheri, Michela Deiana, Arianna Minoia, Natascia Tiso, Monica Mottes and Maria Teresa Valenti

    Citation: Stem Cell Research & Therapy 2021 12:326

    Content type: Research

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  6. Gastric cancer stem cells (CSCs) are the main causes of metastasis and drug resistance. We previously indicated that miR-375 can inhibit Helicobacter pylori-induced gastric carcinogenesis; here, we aim to explore...

    Authors: Haiwei Ni, Hai Qin, Cheng Sun, Yichen Liu, Guojing Ruan, Qianqian Guo, Tao Xi, Yingying Xing and Lufeng Zheng

    Citation: Stem Cell Research & Therapy 2021 12:325

    Content type: Research

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  7. Ulcerative colitis (UC) is a chronic, relapsing, and non-specific inflammatory bowel disease, and the current treatment strategies were mainly used to relieve symptoms or for maintenance. Endometrial regenerat...

    Authors: Dingding Yu, Yiming Zhao, Hongda Wang, Dejun Kong, Wang Jin, Yonghao Hu, Yafei Qin, Baoren Zhang, Xiang Li, Jingpeng Hao, Guangming Li and Hao Wang

    Citation: Stem Cell Research & Therapy 2021 12:324

    Content type: Research

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  8. Necrotizing enterocolitis (NEC) is a devastating disease predominately affecting neonates. Despite therapeutic advances, NEC remains the leading cause of mortality due to gastrointestinal conditions in neonate...

    Authors: Ruijie Zeng, Jinghua Wang, Zewei Zhuo, Yujun Luo, Weihong Sha and Hao Chen

    Citation: Stem Cell Research & Therapy 2021 12:323

    Content type: Review

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  9. Doxorubicin (DOX), a widely used chemotherapeutic agent, can cause neurodegeneration in the brain, which leads to a condition known as chemobrain. In fact, chemobrain is a deteriorating condition which adverse...

    Authors: Marwa O. El-Derany and Mohamed H. Noureldein

    Citation: Stem Cell Research & Therapy 2021 12:322

    Content type: Research

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  10. The human fetal liver is a critical organ for prenatal hematopoiesis, the study of which offers insights into niche signals that regulate the fates of hematopoietic stem and progenitor cells (HSPCs) during fet...

    Authors: Yoon Jung Choi, Adam M. Heck, Brian J. Hayes, Daniel Lih, Samuel G. Rayner, Brandon Hadland and Ying Zheng

    Citation: Stem Cell Research & Therapy 2021 12:321

    Content type: Short report

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  11. Mesenchymal stem/stromal cells (MSC) represent adult cells with multipotent capacity. Besides their capacity to differentiate into multiple lineages in vitro and in vivo, increasing evidence points towards the...

    Authors: Catalina-Iolanda Marinescu, Mihai Bogdan Preda and Alexandrina Burlacu

    Citation: Stem Cell Research & Therapy 2021 12:319

    Content type: Method

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  12. Fat tissue (FT) has been used for many years in regenerative surgery as a bioactive material through the lipofilling/fat graft (F-GRF)–nano-fat technique, as a bioactive scaffold when it was enriched with adip...

    Authors: Pietro Gentile, Aris Sterodimas, Claudio Calabrese and Simone Garcovich

    Citation: Stem Cell Research & Therapy 2021 12:318

    Content type: Review

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  13. Age-related diminished ovarian reserve (AR-DOR) reduced the quality of oocytes, resulting in decreased female fertility. Aging is tightly related to abnormal distribution and function of mitochondria, while mi...

    Authors: Hanwen Liu, Chunyan Jiang, Boya La, Meng Cao, Song Ning, Jing Zhou, Zhengjie Yan, Chuyu Li, Yugui Cui, Xiang Ma, Meilian Wang, Li Chen, Youjia Yu, Feng Chen, Yuexin Zhang, Huimin Wu…

    Citation: Stem Cell Research & Therapy 2021 12:317

    Content type: Research

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  14. Coronavirus disease 2019 (COVID-19) may result in a life-threatening condition due to a hyperactive immune reaction to severe acute respiratory syndrome-coronavirus-2 infection, for which no effective treatmen...

    Authors: Rachele Ciccocioppo, Davide Gibellini, Giuseppe Astori, Martina Bernardi, Angela Bozza, Katia Chieregato, Francesca Elice, Stefano Ugel, Simone Caligola, Francesco De Sanctis, Stefania Canè, Alessandra Fiore, Rosalinda Trovato, Antonio Vella, Varvara Petrova, Giuseppe Amodeo…

    Citation: Stem Cell Research & Therapy 2021 12:316

    Content type: Short report

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  15. Exosomes as the main therapeutic vectors of mesenchymal stem cells (MSC) for inflammatory bowel disease (IBD) treatment and its mechanism remain unexplored. Tumor necrosis factor-α stimulated gene 6 (TSG-6) is...

    Authors: Shaopeng Yang, Xiaonan Liang, Jia Song, Chenyang Li, Airu Liu, Yuxin Luo, Heran Ma, Yi Tan and Xiaolan Zhang

    Citation: Stem Cell Research & Therapy 2021 12:315

    Content type: Research

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  16. The major barriers to mesenchymal stem cell (MSC) therapy in rheumatoid arthritis (RA) are a low extent of tissue regeneration and insufficient immunomodulation after cell transplantation. In addition, the rol...

    Authors: Sung-Tai Wei, Yen-Chih Huang, Jung-Ying Chiang, Chia-Ching Lin, Yu-Jung Lin, Woei-Cherng Shyu, Hui-Chen Chen and Chia-Hung Hsieh

    Citation: Stem Cell Research & Therapy 2021 12:314

    Content type: Research

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  17. Mesenchymal stem cells including adipose-derived stem cells (ASCs) have a considerable potential in the field of translational medicine. Unfortunately, multiple factors (e.g., older age, co-existing diabetes, ...

    Authors: Sen Ren, Hewei Xiong, Jing Chen, Xiaofan Yang, Yutian Liu, Jiahe Guo, Tao Jiang, Zhao Xu, Meng Yuan, Yang Liu, Nan Zhou, Hongrui Chen, Wenqing Li, Hans-Günther Machens and Zhenbing Chen

    Citation: Stem Cell Research & Therapy 2021 12:313

    Content type: Research

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  18. Small hepatocyte-like progenitor cells (SHPCs) appear to form transient clusters in rat livers treated with retrorsine (Ret) and 70% partial hepatectomy (PH). We previously reported that the expansion of SHPCs...

    Authors: Norihisa Ichinohe, Masayuki Ishii, Naoki Tanimizu, Toru Mizuguchi, Yusuke Yoshioka, Takahiro Ochiya, Hiromu Suzuki and Toshihiro Mitaka

    Citation: Stem Cell Research & Therapy 2021 12:312

    Content type: Research

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  19. Fat grafting has been regarded as a promising approach for regenerative therapy. Given the rapidly aging population, better understanding of the effect of age on fat graft outcomes and the underlying mechanism...

    Authors: Xihang Chen, Jingwei Feng, Qiang Chang, Feng Lu and Yi Yuan

    Citation: Stem Cell Research & Therapy 2021 12:311

    Content type: Research

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  20. Mobilization failure may occur when the conventional hematopoietic stem cells (HSCs) mobilization agent granulocyte colony-stimulating factor (G-CSF) is used alone, new regimens were developed to improve mobil...

    Authors: Chengxin Luo, Li Wang, Guixian Wu, Xiangtao Huang, Yali Zhang, Yanni Ma, Mingling Xie, Yanni Sun, Yarui Huang, Zhen Huang, Qiuyue Song, Hui Li, Yu Hou, Xi Li, Shuangnian Xu and Jieping Chen

    Citation: Stem Cell Research & Therapy 2021 12:310

    Content type: Research

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  21. The intestine is particularly sensitive to moderate-high radiation dose and the development of gastrointestinal syndrome (GIS) leads to the rapid loss of intestinal mucosal integrity, resulting in bacterial in...

    Authors: Lydia Bensemmane, Claire Squiban, Christelle Demarquay, Noëlle Mathieu, Marc Benderitter, Bernard Le Guen, Fabien Milliat and Christine Linard

    Citation: Stem Cell Research & Therapy 2021 12:309

    Content type: Research

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  22. Deleterious cutaneous tissue damages could result from exposure to thermal trauma, which could be ameliorated structurally and functionally through therapy via the most multipotent progenitor bone marrow mesen...

    Authors: Doaa Ramadan I. Abdel-Gawad, Walaa A. Moselhy, Rasha Rashad Ahmed, Hessah Mohammed Al-Muzafar, Kamal Adel Amin, Maha Mohamed Amin, El-Shaymaa El-Nahass and Khaled Abbas Helmy Abdou

    Citation: Stem Cell Research & Therapy 2021 12:308

    Content type: Research

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  23. The stem cells of the stem cell banks have prominent problems for insufficient sources, easy contamination, unstable biological characteristics after serial subcultivations, and high cost.

    Authors: Bao-Shi Fan, Yang Liu, Ji-Ying Zhang, You-Rong Chen, Meng Yang and Jia-Kuo Yu

    Citation: Stem Cell Research & Therapy 2021 12:307

    Content type: Review

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  24. Endometrial mesenchymal-like stromal/stem cells (eMSCs) have been proposed as adult stem cells contributing to endometrial regeneration. One set of perivascular markers (CD140b&CD146) has been widely used to e...

    Authors: Dandan Cao, Rachel W. S. Chan, Ernest H. Y. Ng, Kristina Gemzell-Danielsson and William S. B. Yeung

    Citation: Stem Cell Research & Therapy 2021 12:306

    Content type: Research

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  25. Graves’ ophthalmopathy (GO) is a disorder, in which orbital connective tissues get in inflammation and increase in volume. Stimulants such as thyroid-stimulating hormone (TSH), insulin-like growth factor 1(IGF...

    Authors: Mira Park, Jae Yeon Kim, Jun Mo Kang, Hey Jin Lee, Jasvinder Paul Banga, Gi Jin Kim and Helen Lew

    Citation: Stem Cell Research & Therapy 2021 12:304

    Content type: Research

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  26. Nerve injuries are debilitating, leading to long-term motor deficits. Remyelination and axonal growth are supported and enhanced by growth factor and cytokines. Combination of nerve guidance conduits (NGCs) wi...

    Authors: Diego Noé Rodríguez-Sánchez, Giovana Boff Araujo Pinto, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira, Ana Livia Carvalho Bovolato, Marcio de Carvalho, Jorge Vicente Lopes da Silva, Janaina de Andréa Dernowsek, Marjorie Golim, Benedito Barraviera, Rui Seabra Ferreira, Elenice Deffune, Mathues Bertanha and Rogério Martins Amorim

    Citation: Stem Cell Research & Therapy 2021 12:303

    Content type: Research

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  27. Dental pulp stem cells (DPSCs) have been developed as a potential source of mesenchymal stem cells (MSCs) for regeneration of dental pulp and other tissues. However, further strategies to isolate highly functi...

    Authors: Mohammed Zayed, Koichiro Iohara, Hideto Watanabe, Mami Ishikawa, Michiyo Tominaga and Misako Nakashima

    Citation: Stem Cell Research & Therapy 2021 12:302

    Content type: Research

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  28. Powerful constitutive and inducible transgenic / bitransgenic / tritransgenic murine models of breast cancer have been used over the past two decades to shed light on the molecular mechanisms by which the give...

    Authors: Christine Nguyen, Julie P. T. Nguyen, Arnav P. Modi, Ihsaan Ahmad, Sarah C. Petrova, Stuart D. Ferrell Jr, Sabrina R. Wilhelm, Yin Ye, Dorthe Schaue and Sanford H. Barsky

    Citation: Stem Cell Research & Therapy 2021 12:301

    Content type: Research

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  29. Microtubule-stabilizing agents have been demonstrated to modulate axonal sprouting during neuronal disease. One such agent, Epothilone D, has been used to treat spinal cord injury (SCI) by promoting axonal spr...

    Authors: Weiwei Xue, Haipeng Zhang, Yongheng Fan, Zhifeng Xiao, Yannan Zhao, Weiyuan Liu, Bai Xu, Yanyun Yin, Bing Chen, Jiayin Li, Yi Cui, Ya Shi and Jianwu Dai

    Citation: Stem Cell Research & Therapy 2021 12:300

    Content type: Research

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  30. Sepsis is a major cause of death in ICU, and intestinal barrier dysfunction is its important complication, while the treatment is limited. Recently, mesenchymal stem cell-derived microvesicles (MMVs) attract m...

    Authors: Danyang Zheng, Henan Zhou, Hongchen Wang, Yu Zhu, Yue Wu, Qinghui Li, Tao Li and Liangming Liu

    Citation: Stem Cell Research & Therapy 2021 12:299

    Content type: Research

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  31. Recently, neural stem cell (NSC) therapy has shown promise for the treatment of many neurological diseases. Enhancing the quality of implanted cells and improving therapeutic efficacy are currently research ho...

    Authors: Yi Cui, Yanyun Yin, Yunlong Zou, Yannan Zhao, Jin Han, Bai Xu, Bing Chen, Zhifeng Xiao, Hongwei Song, Ya Shi, Weiwei Xue, Xu Ma and Jianwu Dai

    Citation: Stem Cell Research & Therapy 2021 12:298

    Content type: Research

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  32. Recently, mesenchymal stem/stromal cells (MSCs) and their widespread biomedical applications have attracted great consideration from the scientific community around the world. However, reports have shown that ...

    Authors: Ali Hassanzadeh, Heshu Sulaiman Rahman, Alexander Markov, Judi Januadi Endjun, Angelina Olegovna Zekiy, Max Stanley Chartrand, Nasrin Beheshtkhoo, Mohammad Amin Jadidi Kouhbanani, Faroogh Marofi, Marzieh Nikoo and Mostafa Jarahian

    Citation: Stem Cell Research & Therapy 2021 12:297

    Content type: Review

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  33. Cartilage regeneration is a key step in functional reconstruction for temporomandibular joint osteoarthritis (TMJ-OA) but is a difficult issue to address. Strontium ranelate (SrR) is an antiosteoporosis drug t...

    Authors: Hao Yu, Yan Liu, Xiangwen Yang, Jiajing He, Fan Zhang, Qun Zhong and Xiaojing Guo

    Citation: Stem Cell Research & Therapy 2021 12:296

    Content type: Research

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  34. Mesenchymal stem cells (MSCs) can improve cutaneous wound healing via the secretion of growth factors. However, the therapeutic efficacy of MSCs varies depending upon their source. Induced pluripotent stem cel...

    Authors: Xiaoting Liang, Fang Lin, Yue Ding, Yuelin Zhang, Mimi Li, Xiaohui Zhou, Qingshu Meng, Xiaoxue Ma, Lu Wei, Huimin Fan and Zhongmin Liu

    Citation: Stem Cell Research & Therapy 2021 12:295

    Content type: Research

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  35. Liver fibrosis (LF) is a common pathological process characterized by the activation of hepatic stellate cells (HSCs) and accumulation of extracellular matrix. Severe LF causes cirrhosis and even liver failure...

    Authors: Yunqi Yao, Zhemin Xia, Fuyi Cheng, Qingyuan Jang, Jiao He, Cheng Pan, Lin Zhang, Yixin Ye, Yuan Wang, Shuang Chen, Dongsheng Su, Xiaolan Su, Lin Cheng, Gang Shi, Lei Dai and Hongxin Deng

    Citation: Stem Cell Research & Therapy 2021 12:294

    Content type: Research

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  36. Although promising, clinical translation of human mesenchymal stem or stromal cell-derived extracellular vesicles (MSC EV) for acute lung injury is potentially limited by significant production costs. The curr...

    Authors: Li Zhou, Qi Hao, Shinji Sugita, Yoshifumi Naito, Hongli He, Che-chung Yeh and Jae-Woo Lee

    Citation: Stem Cell Research & Therapy 2021 12:293

    Content type: Research

    Published on:

  37. There are over 17,000 patients in the US waiting to receive liver transplants, and these numbers are increasing dramatically. Significant effort is being made to obtain functional hepatocytes and liver tissue ...

    Authors: M. Ruiz-Estevez, A. T. Crane, P. Rodriguez-Villamil, F. L. Ongaratto, Yun You, A. R. Steevens, C. Hill, T. Goldsmith, D. A. Webster, L. Sherry, S. Lim, N. Denman, W. C. Low, D. F. Carlson, J. R. Dutton, C. J. Steer…

    Citation: Stem Cell Research & Therapy 2021 12:292

    Content type: Research

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  38. Glucocorticoid-induced osteoporosis (GIOP) is the most common secondary osteoporosis. Patients with GIOP are susceptible to fractures and the subsequent delayed bone union or nonunion. Thus, effective drugs an...

    Authors: Hai-Tao Jiang, Rui Deng, Yan Deng, Mao Nie, Yi-Xuan Deng, Hong-Hong Luo, Yuan-Yuan Yang, Na Ni, Cheng-Cheng Ran and Zhong-Liang Deng

    Citation: Stem Cell Research & Therapy 2021 12:291

    Content type: Research

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  39. Acute lung injury (ALI) remains a common cause of morbidity and mortality worldwide, and to date, there is no effective treatment for ALI. Previous studies have revealed that topical administration of mesenchy...

    Authors: Haijin Lv, Xiaofeng Yuan, Jiebin Zhang, Tongyu Lu, Jia Yao, Jun Zheng, Jianye Cai, Jiaqi Xiao, Haitian Chen, Shujuan Xie, Ying Ruan, Yuling An, Xin Sui and Huimin Yi

    Citation: Stem Cell Research & Therapy 2021 12:290

    Content type: Research

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  40. Recent studies demonstrated that autologous mitochondria derived from bone marrow mesenchymal stem cells (BMSCs) might be valuable in the treatment of spinal cord injury (SCI). However, the mechanisms of mitoc...

    Authors: Jing Li, Heyangzi Li, Simin Cai, Shi Bai, Huabo Cai and Xiaoming Zhang

    Citation: Stem Cell Research & Therapy 2021 12:289

    Content type: Research

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  41. In spite of clinical progress, cardiovascular disease (CVD) remains the predominant cause of mortality worldwide. Overexpression studies in animals have proven miR-424-5p to have anti-angiogenic properties. As...

    Authors: Alice Tamara, David J. Coulson, Jevi Septyani Latief, Sherin Bakhashab and Jolanta U. Weaver

    Citation: Stem Cell Research & Therapy 2021 12:249

    Content type: Research

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  42. Both advanced glycation end products (AGEs) and AGE-mediated M1 macrophage polarization contribute to bone marrow mesenchymal stem cell (BMSC) dysfunction, leading to impaired bone regeneration in type 1 diabe...

    Authors: Feng Wang, Lingchi Kong, Wenbo Wang, Li Shi, Mengwei Wang, Yimin Chai, Jia Xu and Qinglin Kang

    Citation: Stem Cell Research & Therapy 2021 12:288

    Content type: Research

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  43. Griscelli syndrome type 2 (GS-2) is a rare, autosomal recessive immune deficiency syndrome caused by a mutation in the RAB27A gene, which results in the absence of a protein involved in vesicle trafficking and co...

    Authors: Gülen Güney-Esken, Özgür Doğuş Erol, Burcu Pervin, Gülben Gürhan Sevinç, Tamer Önder, Elif Bilgiç, Petek Korkusuz, Ayşen Günel-Özcan, Duygu Uçkan-Çetinkaya and Fatima Aerts-Kaya

    Citation: Stem Cell Research & Therapy 2021 12:287

    Content type: Research

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  44. Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) have emerged as a promising new therapeutic strategy for intervertebral disc degeneration (IVDD). However, the drawbacks of MSCs, including...

    Authors: Yongjin Sun, Wenzhi Zhang and Xu Li

    Citation: Stem Cell Research & Therapy 2021 12:286

    Content type: Research

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  45. Vitamin D3 is important for normal function of the intestinal epithelial cells (IECs). In this study, we aimed to investigate the effects of vitamin D3 on the differentiation, stemness, and viability of healthy I...

    Authors: Panida Sittipo, Hyun Kyu Kim, Jaeseok Han, Man Ryul Lee and Yun Kyung Lee

    Citation: Stem Cell Research & Therapy 2021 12:285

    Content type: Research

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  46. Existing evidence has shown that mesenchymal stem cells (MSCs) can undergo malignant transformation, which is a serious limitation of MSC-based therapies. Therefore, it is necessary to monitor malignant transf...

    Authors: Jun Sun, Jie Huang, Guangcheng Bao, Helin Zheng, Cui Wang, Jie Wei, Yuanqiao Fu, Jiawen Qiu, Yifan Liao and Jinhua Cai

    Citation: Stem Cell Research & Therapy 2021 12:284

    Content type: Research

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  47. The global health emergency of COVID-19 has necessitated the development of multiple therapeutic modalities including vaccinations, antivirals, anti-inflammatory, and cytoimmunotherapies, etc. COVID-19 patient...

    Authors: Birbal Singh, Gorakh Mal, Vinod Verma, Ruchi Tiwari, Muhammad Imran Khan, Ranjan K. Mohapatra, Saikat Mitra, Salem A. Alyami, Talha Bin Emran, Kuldeep Dhama and Mohammad Ali Moni

    Citation: Stem Cell Research & Therapy 2021 12:283

    Content type: Review

    Published on:

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