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  1. Skin wounding is very common and may be slow to heal. Increasing evidence shows that exosomes derived from mesenchymal stem cells (MSCs) dramatically enhance skin wound healing in a paracrine manner. However, ...

    Authors: Guifang Zhao, Feilin Liu, Zinan Liu, Kuiyang Zuo, Bo Wang, Yuying Zhang, Xing Han, Aobo Lian, Yuan Wang, Mingsheng Liu, Fei Zou, Pengdong Li, Xiaomei Liu, Minghua Jin and Jin Yu Liu

    Citation: Stem Cell Research & Therapy 2020 11:174

    Content type: Research

    Published on:

  2. A commentary to “Hertegård, S., Nagubothu, S.R., Malmström, E. et al. Treatment of vocal fold scarring with autologous bone marrow-derived human mesenchymal stromal cells - first phase I/II human clinical stud...

    Authors: Alexia Mattei, Jérémy Magalon, Mélanie Velier, Françoise Dignat-George, Antoine Giovanni and Florence Sabatier

    Citation: Stem Cell Research & Therapy 2020 11:173

    Content type: Commentary

    Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:128

    The Commentary to this article has been published in Stem Cell Research & Therapy 2020 11:235

  3. Cardiovascular diseases are the main cause of morbidity and mortality worldwide. Restoring blood supply to ischemic tissues is an essential goal for the successful treatment of these diseases. Growth factor or...

    Authors: Richard Proust, Anne-Charlotte Ponsen, Valérie Rouffiac, Chantal Schenowitz, Florent Montespan, Karine Ser-Le Roux, Frédéric De Leeuw, Corinne Laplace-Builhé, Philippe Mauduit, Edgardo D. Carosella, Sébastien Banzet, Jean-Jacques Lataillade, Nathalie Rouas-Freiss, Georges Uzan and Juliette Peltzer

    Citation: Stem Cell Research & Therapy 2020 11:172

    Content type: Research

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  4. Rheumatoid arthritis (RA) is characterized by joint inflammation and damage to the cartilage and bone in collagen-induced arthritis (CIA). Mesenchymal stem cells (MSCs) can improve articular symptoms and reduc...

    Authors: Jinfang Gao, Gailian Zhang, Ke Xu, Dan Ma, Limin Ren, Jingjing Fan, Jianwen Hou, Jian Han and Liyun Zhang

    Citation: Stem Cell Research & Therapy 2020 11:171

    Content type: Research

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  5. Cancer stem cells (CSCs) have been proposed to be responsible for tumor recurrence and chemo-resistance. Previous studies suggested that miR-153 played essential roles in lung cancer. However, the molecular me...

    Authors: Guoli Zhao, Yueying Zhang, Zhonghua Zhao, Haibo Cai, Xiaogang Zhao, Tong Yang, Weijun Chen, Chengfang Yao, Zhaopeng Wang, Zhaoxia Wang, Chen Han and Hengxiao Wang

    Citation: Stem Cell Research & Therapy 2020 11:170

    Content type: Research

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  6. The outbreak of 2019 novel coronavirus disease (COVID-19) worldwide is becoming rapidly a major concern. The number of severe cases has increased dramatically worldwide, while specific treatment options are sc...

    Authors: Shan Liu, Danyi Peng, Huijun Qiu, Ke Yang, Zhou Fu and Lin Zou

    Citation: Stem Cell Research & Therapy 2020 11:169

    Content type: Commentary

    Published on:

  7. Diabetic polyneuropathy (DPN) is the most common and early developing complication of diabetes mellitus, and the key contributor for foot ulcers development, with no specific therapies available.

    Authors: Cristian De Gregorio, David Contador, Diego Díaz, Constanza Cárcamo, Daniela Santapau, Lorena Lobos-Gonzalez, Cristian Acosta, Mario Campero, Daniel Carpio, Caterina Gabriele, Marco Gaspari, Victor Aliaga-Tobar, Vinicius Maracaja-Coutinho, Marcelo Ezquer and Fernando Ezquer

    Citation: Stem Cell Research & Therapy 2020 11:168

    Content type: Research

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  8. Despite recent advances in understanding its pathophysiology and development of novel therapies, asthma remains a serious public health issue worldwide. Combination therapy with inhaled corticosteroids and lon...

    Authors: Fabio S. Aguiar, André S. Melo, Ana Maria S. Araújo, Alexandre P. Cardoso, Sergio Augusto L. de Souza, Miquéias Lopes-Pacheco, Fernanda F. Cruz, Debora G. Xisto, Karina D. Asensi, Lanuza Faccioli, Anna Beatriz S. Salgado, Maria Carolina P. P. Landesmann, Regina C. S. Goldenberg, Bianca Gutfilen, Marcelo M. Morales, Patricia R. M. Rocco…

    Citation: Stem Cell Research & Therapy 2020 11:167

    Content type: Research

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  9. Fibroblasts are crucial for supporting normal wound healing. However, the functional state of these cells is impaired in diabetics because of a high-glucose (HG) microenvironment. Small extracellular vesicles ...

    Authors: Xiaowei Bian, Bingmin Li, Jie Yang, Kui Ma, Mengli Sun, Cuiping Zhang and Xiaobing Fu

    Citation: Stem Cell Research & Therapy 2020 11:166

    Content type: Research

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  10. Mesenchymal stromal cell (MSC)-enriched products showed positive clinical outcomes in regenerative medicine, where tissue restoration and inflammation control are needed. GMP-expanded MSCs displayed an even hi...

    Authors: Enrico Ragni, Carlotta Perucca Orfei, Paola De Luca, Carlotta Mondadori, Marco Viganò, Alessandra Colombini and Laura de Girolamo

    Citation: Stem Cell Research & Therapy 2020 11:165

    Content type: Research

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  11. CD18 is the common beta subunit of β2 integrins, which are expressed on hematopoietic cells. β2 integrins are essential for cell adhesion and leukocyte trafficking.

    Authors: Cristina Mesa-Núñez, Diego Leon-Rico, Montserrat Aldea, Carlos Damián, Raquel Sanchez-Baltasar, Rebeca Sanchez, Omaira Alberquilla, José Carlos Segovia, Juan Antonio Bueren and Elena Almarza

    Citation: Stem Cell Research & Therapy 2020 11:164

    Content type: Research

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  12. Human embryonic stem cells represent a potentially unlimited source of insulin-producing cells for diabetes therapy. While tremendous progress has been made in directed differentiation of human embryonic stem ...

    Authors: Fei He, Ning Li, Hai-Bo Huang, Jing-Bo Wang, Xiao-Fei Yang, Hua-Dong Wang, Wei Huang and Fu-Rong Li

    Citation: Stem Cell Research & Therapy 2020 11:163

    Content type: Research

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  13. M2 macrophages and exosomes from adipose-derived stem cells (ASCs) are both reported to promote angiogenesis. However, the possible synergistic effects between exogenous exosomes and endogenous M2 macrophages ...

    Authors: Dihan Zhu, Takerra K. Johnson, Yang Wang, Miracle Thomas, Ky Huynh, Qinglin Yang, Vincent C. Bond, Y. Eugene Chen and Dong Liu

    Citation: Stem Cell Research & Therapy 2020 11:162

    Content type: Research

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  14. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have been shown to have therapeutic potential for ischemic diseases and are considered an alternative to cell therapy. However, the low retentio...

    Authors: Yue Liu, Jian Cui, Hongfen Wang, Kamal Hezam, Xiaotong Zhao, Haoyan Huang, Shang Chen, Zhibo Han, Zhong-Chao Han, Zhikun Guo and Zongjin Li

    Citation: Stem Cell Research & Therapy 2020 11:161

    Content type: Research

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  15. Runt-related transcription factor 1 translocated to 1 (Runx1t1) is one of the members of the myeloid translocation gene family. Our previous work showed that Runx1t1 induced the neuronal differentiation of rad...

    Authors: Linqing Zou, Haoming Li, Xiao Han, Jianbing Qin and Guoqi Song

    Citation: Stem Cell Research & Therapy 2020 11:160

    Content type: Research

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  16. Human amniotic epithelial cell (hAEC) transplantation holds great promise in treating premature ovarian insufficiency (POI). However, some deficient biological characteristics of hAECs restrict their application.

    Authors: Shunyu Hou, Chenyue Ding, Han Shen, Chunfeng Qian, Qinyan Zou, Jiafeng Lu, Boxian Huang, Jichun Tan and Hong Li

    Citation: Stem Cell Research & Therapy 2020 11:159

    Content type: Research

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  17. Mesenchymal stromal cells (MSCs) represent an interesting tool to improve pancreatic islet transplantation. They have immunomodulatory properties and secrete supportive proteins. However, the functional proper...

    Authors: Orianne Villard, Mathieu Armanet, Guilhem Couderc, Claire Bony, Jerome Moreaux, Daniele Noël, John DeVos, Bernard Klein, Jean-Luc Veyrune and Anne Wojtusciszyn

    Citation: Stem Cell Research & Therapy 2020 11:158

    Content type: Research

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    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:190

  18. The development of somatic reprogramming, especially purely chemical reprogramming, has significantly advanced biological research. And chemical-induced extraembryonic endoderm-like (ciXEN) cells have been con...

    Authors: Xia He, Guangfan Chi, Meiying Li, Jinying Xu, Lihong Zhang, Yaolin Song, Lina Wang and Yulin Li

    Citation: Stem Cell Research & Therapy 2020 11:157

    Content type: Research

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  19. Mesenchymal stem cell (MSC) therapy is an important alternative for GVHD treatment, but a third of patients fail to respond to such therapy. Therefore, strategies to enhance the immunosuppressive potential of ...

    Authors: Amandda Évelin Silva-Carvalho, Leane Perim Rodrigues, Josiane Lilian Schiavinato, Marcos Rodrigo Alborghetti, Gustavo Bettarello, Belinda Pinto Simões, Francisco de Assis Rocha Neves, Rodrigo Alexandre Panepucci, Juliana Lott de Carvalho and Felipe Saldanha-Araujo

    Citation: Stem Cell Research & Therapy 2020 11:156

    Content type: Research

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  20. The limited neuronal differentiation of the endogenous or grafted neural stem cells (NSCs) after brain injury hampers the clinic usage of NSCs. Panax notoginseng saponins (PNS) were extensively used for their cli...

    Authors: Liu-Lin Xiong, De-Lu Qiu, Guang-Hui Xiu, Mohammed Al-Hawwas, Ya Jiang, You-Cui Wang, Yue Hu, Li Chen, Qing-Jie Xia and Ting-Hua Wang

    Citation: Stem Cell Research & Therapy 2020 11:155

    Content type: Research

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  21. Hepatocyte-like cells (iHEPs) generated by transcription factor-mediated direct reprogramming of somatic cells have been studied as potential cell sources for the development of novel therapies targeting liver...

    Authors: Iasmim Diniz Orge, Victoria L. Gadd, Judah Leão Barouh, Erik Aranha Rossi, Rejane Hughes Carvalho, Ian Smith, Kyan James Allahdadi, Bruno Diaz Paredes, Daniela Nascimento Silva, Patrícia Kauanna F. Damasceno, Gabriela Louise Sampaio, Stuart J. Forbes, Milena Botelho Pereira Soares and Bruno Solano de Freitas Souza

    Citation: Stem Cell Research & Therapy 2020 11:154

    Content type: Research

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  22. To date, it has repeatedly been demonstrated that infusing bone marrow-derived stem cells (BMSCs) into acellular nerve scaffolds can promote and support axon regeneration through a peripheral nerve defect. How...

    Authors: Li Na Zhou, Jia Chuan Wang, Prince Last Mudenda Zilundu, Ya Qiong Wang, Wen Ping Guo, Sai Xia Zhang, Hui Luo, Jian Hong Zhou, Ru Dong Deng and Dong Feng Chen

    Citation: Stem Cell Research & Therapy 2020 11:153

    Content type: Research

    Published on:

  23. Chronic rhinosinusitis (CRS) is characterized by persistent symptomatic inflammation of the nasal passage and sinus mucosa. Various microRNAs (miRs) have been implicated in CRS. Hence, the current study was co...

    Authors: Jinzhang Cheng, Junjun Chen, Yin Zhao, Jingpu Yang, Kai Xue and Zonggui Wang

    Citation: Stem Cell Research & Therapy 2020 11:151

    Content type: Research

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  24. Urine-derived stem cells (USCs) are a valuable stem cell source for tissue engineering because they can be harvested non-invasively. Small intestine submucosa (SIS) has been used as scaffolds for soft tissue r...

    Authors: Xiu-Ru Zhang, Yi-Zhou Huang, Hong-Wei Gao, Yan-Lin Jiang, Jun-Gen Hu, Jin-Kui Pi, An-Jing Chen, Yi Zhang, Li Zhou and Hui-Qi Xie

    Citation: Stem Cell Research & Therapy 2020 11:150

    Content type: Research

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  25. Mesenchymal stem/stromal cells (MSCs) are multipotent cells with a promising application potential in regenerative medicine and immunomodulation. However, MSCs cultured in vitro exhibit functional heterogeneit...

    Authors: Changbin Sun, Lei Wang, Hailun Wang, Tingrun Huang, Wenwen Yao, Jing Li and Xi Zhang

    Citation: Stem Cell Research & Therapy 2020 11:149

    Content type: Research

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  26. Adipose-derived stem cell (ADSC) transplantation is a promising strategy to promote wound healing because of the paracrine function of stem cells. However, glucose-associated effects on stem cell paracrine fun...

    Authors: Jin Xu, Xiaoyu Liu, Feng Zhao, Ying Zhang and Zhe Wang

    Citation: Stem Cell Research & Therapy 2020 11:148

    Content type: Research

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  27. Strategies of generating functional blood cells from human pluripotent stem cells (hPSCs) remain largely unsuccessful due to the lack of a comprehensive understanding of hematopoietic development. Endothelial-...

    Authors: Hongtao Wang, Mengge Wang, Yu Wang, Yuqi Wen, Xiaoyuan Chen, Dan Wu, Pei Su, Wen Zhou, Lihong Shi and Jiaxi Zhou

    Citation: Stem Cell Research & Therapy 2020 11:147

    Content type: Research

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    The Correction to this article has been published in Stem Cell Research & Therapy 2020 11:242

  28. Mesenchymal stem/stromal cells (MSCs) can replenish the aged cells of the musculoskeletal system in adult life. Stem cell exhaustion and decrease in their regenerative potential have been suggested to be hallm...

    Authors: Klemen Čamernik, Anže Mihelič, Rene Mihalič, Gregor Haring, Simon Herman, Darja Marolt Presen, Andrej Janež, Rihard Trebše, Janja Marc and Janja Zupan

    Citation: Stem Cell Research & Therapy 2020 11:146

    Content type: Research

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  29. Bone marrow mesenchymal stem cells (BMSCs) have shown their therapeutic potential in cytotherapy for liver fibrosis. However, the insufficient homing of BMSCs and undefined proliferation of BMSCs represent a s...

    Authors: Ting Sun, Hualin Li, Yun Bai, Min Bai, Feng Gao, Jie Yu, Rong Wu, Lianfang Du and Fan Li

    Citation: Stem Cell Research & Therapy 2020 11:145

    Content type: Research

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  30. Cultured epidermal stem cells (Epi-SCs) and skin-derived precursors (SKPs) were capable of reconstituting functional hair follicles after implantation, while the signaling pathways that regulate neogenic hair ...

    Authors: Yu Chen, Zhimeng Fan, Xiaoxiao Wang, Miaohua Mo, Shu Bin Zeng, Ren-He Xu, Xusheng Wang and Yaojiong Wu

    Citation: Stem Cell Research & Therapy 2020 11:144

    Content type: Short report

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  31. Factors such as poor engraftment, retention, and survival of the transplanted stem cells are deemed to limit their therapeutic efficacy for wound regeneration. Hence, it is necessary to explore these issues in...

    Authors: Qingzha Deng, Sunxing Huang, Jinkun Wen, Yiren Jiao, Xiaohu Su, Guang Shi and Junjiu Huang

    Citation: Stem Cell Research & Therapy 2020 11:143

    Content type: Research

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  32. Retinal degeneration is a leading cause of blindness in the world; its etiology is complex and involves genetic defects and stress-associated aging. In addition to gene therapies for known genetically defectiv...

    Authors: Xiao Liu, Fenghua Chen, Yao Chen, Huayi Lu, Xiaoqin Lu, Xiaoyan Peng, Henry J. Kaplan, Douglas C. Dean, Ling Gao and Yongqing Liu

    Citation: Stem Cell Research & Therapy 2020 11:142

    Content type: Research

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  33. Three-dimensional (3D) cultivation with biomaterials was proposed to facilitate stem cell epithelial differentiation for wound healing. However, whether human adipose-derived stem cells (hASCs) on collagen spo...

    Authors: Minxiong Li, Jun Ma, Yanbin Gao, Mengru Dong, Zijun Zheng, Yuchen Li, Rongwei Tan, Zhending She and Lei Yang

    Citation: Stem Cell Research & Therapy 2020 11:141

    Content type: Research

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  34. Glucocorticoid (GC)-associated osteonecrosis of the femoral head (ONFH) is the most common in non-traumatic ONFH. Despite a strong relationship between GC and ONFH, the detailed mechanisms have remained elusiv...

    Authors: Xudong Yao, Shengnan Yu, Xingzhi Jing, Jiachao Guo, Kai Sun, Fengjing Guo and Yaping Ye

    Citation: Stem Cell Research & Therapy 2020 11:140

    Content type: Research

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  35. To date, many attempts are employed to increase the regenerative potential of stem cells. In this study, we evaluated the hypothesis of whether an autophagy modulation could alter differentiation potency of CD146

    Authors: Mehdi Hassanpour, Jafar Rezaie, Masoud Darabi, Amirataollah Hiradfar, Reza Rahbarghazi and Mohammad Nouri

    Citation: Stem Cell Research & Therapy 2020 11:139

    Content type: Research

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  36. Receptor tyrosine kinase-like orphan receptor 2 (Ror2) plays a key role in bone formation, but its signaling pathway is not completely understood. Signal transducer and activator of transcription 3 (Stat3) tak...

    Authors: Lizhen Lei, Zhuwei Huang, Jingyi Feng, Zijing Huang, Yiwei Tao, Xiaoli Hu and Xiaolei Zhang

    Citation: Stem Cell Research & Therapy 2020 11:137

    Content type: Research

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  37. Due to the low survival rate of cell transplantation, stem cell has not been widely used in clinical treatment of acute myocardial infarction (AMI). In this study, we immobilized the C domain peptide of insuli...

    Authors: Yong Yao, Liang Yang, Li-feng Feng, Zhi-wei Yue, Nian-huan Zhao, Zongjin Li and Zuo-xiang He

    Citation: Stem Cell Research & Therapy 2020 11:136

    Content type: Research

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  38. Bone defects are a common clinical condition that has gained an increasing amount of attention in recent years. Causes of bone defect include tumors, inflammation, and fractures. Bone tissue engineering is a n...

    Authors: Yuan Zhu, Xiao Zhang, Ranli Gu, Xuenan Liu, Siyi Wang, Dandan Xia, Zheng Li, Xiaomin Lian, Ping Zhang, Yunsong Liu and Yongsheng Zhou

    Citation: Stem Cell Research & Therapy 2020 11:135

    Content type: Research

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  39. Human deciduous pulp stem cells (hDPSCs) have remarkable stem cell potency associated with cell proliferation, mesenchymal multipotency, and immunosuppressive function and have shown beneficial effects in a va...

    Authors: Tsuyoshi Iwanaka, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Shouichi Ohga, Yoshinao Oda and Tomoaki Taguchi

    Citation: Stem Cell Research & Therapy 2020 11:134

    Content type: Research

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  40. In our previous research, we found that mesenchymal stem cell (MSC) transplantation therapy can inhibit intimal hyperplasia and enhance endothelial function in arterialized vein grafts in rats. However, whethe...

    Authors: Qingxi Qu, Yingxin Pang, Chunmei Zhang, Linghong Liu and Yanwen Bi

    Citation: Stem Cell Research & Therapy 2020 11:133

    Content type: Research

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  41. Myelodysplastic syndrome (MDS) represents a heterogeneous group of clonal hematopoietic disorders, which is characterized by cytopenias in the peripheral blood and bone marrow dysplasia due to ineffective hema...

    Authors: Khaja Syed, Sara Naguib, Zhao-Jun Liu, Luisa Cimmino and Feng-Chun Yang

    Citation: Stem Cell Research & Therapy 2020 11:132

    Content type: Review

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  42. Hypercholesterolemia increases the risk of tendon pain and tendon rupture. Tendon-derived stem cells (TDSCs) play a vital role in the development of tendinopathy. Our previous research found that high choleste...

    Authors: Kaiqun Li, Ye Deng, Ganming Deng, Pengyu Chen, Yutian Wang, Hangtian Wu, Zhiguo Ji, Zilong Yao, Xianrong Zhang, Bin Yu and Kairui Zhang

    Citation: Stem Cell Research & Therapy 2020 11:131

    Content type: Research

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  43. Mesenchymal stem cells (MSCs) have been reported to promote the regeneration of injured tissue via their paracrine abilities, which are enhanced by hypoxic preconditioning. In this study, we examined the thera...

    Authors: Naoki Ishiuchi, Ayumu Nakashima, Shigehiro Doi, Ken Yoshida, Satoshi Maeda, Ryo Kanai, Yumi Yamada, Takeshi Ike, Toshiki Doi, Yukio Kato and Takao Masaki

    Citation: Stem Cell Research & Therapy 2020 11:130

    Content type: Research

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  44. Distraction osteogenesis (DO) is a surgical technique to promote bone regeneration which may require long duration for bone consolidation. Bone marrow-derived mesenchymal stem cells (MSCs) have been applied to...

    Authors: Yanhua Yang, Qi Pan, Kaijie Zou, Haixing Wang, Xiaoting Zhang, Zhengmeng Yang, Wayne Yuk Wai Lee, Bo Wei, Weidong Gu, Yunzhi Peter Yang, Sien Lin and Gang Li

    Citation: Stem Cell Research & Therapy 2020 11:129

    Content type: Research

    Published on:

  45. Vocal fold (VF) scarring, caused by surgery or inflammation, often results in severe voice problems or aphonia. Effective lasting treatment is lacking. Previous in vitro and in vivo animal studies reported pos...

    Authors: Stellan Hertegård, Srinivasa Rau Nagubothu, Emma Malmström and Katarina LeBlanc

    Citation: Stem Cell Research & Therapy 2020 11:128

    Content type: Research

    Published on:

    The Commentary to this article has been published in Stem Cell Research & Therapy 2020 11:173

  46. Organ replacement regenerative therapy based on human adult stem cells may be effective for salivary gland hypofunction. However, the generated tissues are immature because the signaling factors that induce th...

    Authors: Yi Sui, Siqi Zhang, Yongliang Li, Xin Zhang, Waner Hu, Yanrui Feng, Jingwei Xiong, Yuanyuan Zhang and Shicheng Wei

    Citation: Stem Cell Research & Therapy 2020 11:127

    Content type: Research

    Published on:

  47. The discovery of induced pluripotent stem cells (iPSCs) opened the possibilities for reprogramming cells back to a pluripotent state. Because of no apparent ethical issues connected with donation and derivatio...

    Authors: Marcin Orzechowski, Maximilian Schochow, Michael Kühl and Florian Steger

    Citation: Stem Cell Research & Therapy 2020 11:126

    Content type: Research

    Published on:

  48. Mesenchymal stem cells (MSCs) have been intensively investigated as to their therapeutic potentials. However, the full chemical-defined medium supporting the isolation and expansion of human MSCs has not been ...

    Authors: Jianyong Xu, Wei Lian, Jieting Chen, Wenlei Li, Lingyun Li and Zhong Huang

    Citation: Stem Cell Research & Therapy 2020 11:125

    Content type: Research

    Published on:

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