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  1. Chemotherapy-induced alopecia (CIA) is a distressing adverse effect of chemotherapy, with an estimated incidence of 65% and limited treatment options. Cyclophosphamide (CYP) is a common alopecia-inducing chemo...

    Authors: Hui Chen, Satoshi Yamaguchi, Yilin Wang, Kento Kaminogo, Kiyoshi Sakai and Hideharu Hibi
    Citation: Stem Cell Research & Therapy 2024 15:84
  2. Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease caused by a gain-of-function mutation in ACVR1, which is a bone morphogenetic protein (BMP) type I receptor. Moreover, it causes progressiv...

    Authors: Pan Gao, Yoshiko Inada, Akitsu Hotta, Hidetoshi Sakurai and Makoto Ikeya
    Citation: Stem Cell Research & Therapy 2024 15:83
  3. Authors: Helena Debiazi Zomer, Victor Juan de Souza Lima, Monique Coelho Bion, Karynne Nazare Lins Brito, Michele Rode, Marco Augusto Stimamiglio, Talita da Silva Jeremias and Andrea Gonçalves Trentin
    Citation: Stem Cell Research & Therapy 2024 15:82

    The original article was published in Stem Cell Research & Therapy 2024 15:15

  4. Human corneal endothelial cells lack regenerative capacity through cell division in vivo. Consequently, in the case of trauma or dystrophy, the only available treatment modality is corneal tissue or primary corne...

    Authors: Pyry Grönroos, Anni Mörö, Paula Puistola, Karoliina Hopia, Maija Huuskonen, Taina Viheriälä, Tanja Ilmarinen and Heli Skottman
    Citation: Stem Cell Research & Therapy 2024 15:81
  5. Despite advances in neonatal care, the incidence of Bronchopulmonary Dysplasia (BPD) remains high among preterm infants. Human induced pluripotent stem cells (hiPSCs) have shown promise in repairing injury in ...

    Authors: Hala Saneh, Heather Wanczyk, Joanne Walker and Christine Finck
    Citation: Stem Cell Research & Therapy 2024 15:80
  6. The discovery of material transfer between transplanted and host mouse photoreceptors has expanded the possibilities for utilizing transplanted photoreceptors as potential vehicles for delivering therapeutic c...

    Authors: Margaret T. Ho, Kotoe Kawai, Dhana Abdo, Lacrimioara Comanita, Arturo Ortin-Martinez, Yui Ueno, Emily Tsao, Azam Rastgar-Moghadam, Chang Xue, Hong Cui, Valerie A. Wallace and Molly S. Shoichet
    Citation: Stem Cell Research & Therapy 2024 15:79
  7. Drug induced bile duct injury is a frequently observed clinical problem leading to a wide range of pathological features. During the past decades, several agents have been identified with various postulated me...

    Authors: Zhenguo Wang, Chen Xing, Luc J. W. van der Laan, Monique M. A. Verstegen, Bart Spee and Rosalinde Masereeuw
    Citation: Stem Cell Research & Therapy 2024 15:78
  8. Mesenchymal stem/stromal cells (MSCs) can regenerate tissues through engraftment and differentiation but also via paracrine signalling via extracellular vesicles (EVs). Fetal-derived MSCs (fMSCs) have been sho...

    Authors: Emine Begüm Gençer, Yuk Kit Lor, Fawaz Abomaray, Samir El Andaloussi, Maria Pernemalm, Nidhi Sharma, Daniel W Hagey, André Görgens, Manuela O Gustafsson, Katarina Le Blanc, Mawaddah Asad Toonsi, Lilian Walther-Jallow and Cecilia Götherström
    Citation: Stem Cell Research & Therapy 2024 15:77
  9. A traditional view is that stem cells (SCs) divide slowly. Meanwhile, both embryonic and pluripotent SCs display a shorter cell cycle duration (CCD) in comparison to more committed progenitors (CPs).

    Authors: Tong Xiao, Ugomma C Eze, Alex Charruyer-Reinwald, Tracy Weisenberger, Ayman Khalifa, Brook Abegaze, Gabrielle K Schwab, Rasha H Elsabagh, T. Richard Parenteau, Karl Kochanowski, Merisa Piper, Yumin Xia, Jeffrey B Cheng, Raymond J Cho and Ruby Ghadially
    Citation: Stem Cell Research & Therapy 2024 15:76
  10. Annulus fibrosis (AF) defects have been identified as the primary cause of disc herniation relapse and subsequent disc degeneration following discectomy. Stem cell-based tissue engineering offers a promising a...

    Authors: Li Yu, Honghao Wu, Shumei Zeng, Xiaojian Hu, Yuxu Wu, Jinhong Zhou, Li Yuan, Qingqing Zhang, Charlie Xiang and Zhiyun Feng
    Citation: Stem Cell Research & Therapy 2024 15:75
  11. Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) play a pivotal role in maintaining lifelong hematopoiesis. The distinction between stem cells and other progenitors, as well as the assessment...

    Authors: Shen Wang, Jianzhong Han, Jingru Huang, Khayrul Islam, Yuheng Shi, Yuyuan Zhou, Dongwook Kim, Jane Zhou, Zhaorui Lian, Yaling Liu and Jian Huang
    Citation: Stem Cell Research & Therapy 2024 15:74
  12. Cell- or tissue-based regenerative therapy is an attractive approach to treat heart failure. A tissue patch that can safely and effectively repair damaged heart muscle would greatly improve outcomes for patien...

    Authors: Shigeru Miyagawa, Takuji Kawamura, Emiko Ito, Maki Takeda, Hiroko Iseoka, Junya Yokoyama, Akima Harada, Noriko Mochizuki-Oda, Yukiko Imanishi-Ochi, Junjun Li, Masao Sasai, Fumiyo Kitaoka, Masaki Nomura, Naoki Amano, Tomoko Takahashi, Hiromi Dohi…
    Citation: Stem Cell Research & Therapy 2024 15:73
  13. Hematopoietic acute radiation syndrome (H-ARS) occurring after exposure to ionizing radiation damages bone marrow causing cytopenias, increasing susceptibility to infections and death. We and others have show...

    Authors: John A. Kink, Michael A. Bellio, Matthew H. Forsberg, Alexandra Lobo, Anna S. Thickens, Bryson M. Lewis, Irene M. Ong, Aisha Khan, Christian M. Capitini and Peiman Hematti
    Citation: Stem Cell Research & Therapy 2024 15:72
  14. Liver transplantation remains the only curative treatment for end-stage liver diseases. Unfortunately, there is a drastic organ donor shortage. Hepatocyte transplantation emerged as a viable alternative to liv...

    Authors: Malika Gantier, Raphaël Rispal, Angélique Fourrier, Séverine Ménoret, Frédéric Delbos, Ignacio Anegon and Tuan Huy Nguyen
    Citation: Stem Cell Research & Therapy 2024 15:71
  15. Initially discovered for its ability to regenerate ear holes, the Murphy Roth Large (MRL) mouse has been the subject of multiple research studies aimed at evaluating its ability to regenerate other body tissue...

    Authors: Sarah Bahraoui, Gautier Tejedor, Anne-Laure Mausset-Bonnefont, François Autelitano, Audrey Barthelaix, Claudia Terraza-Aguirre, Vincent Gisbert, Yoan Arribat, Christian Jorgensen, Mingxing Wei and Farida Djouad
    Citation: Stem Cell Research & Therapy 2024 15:70
  16. A significant unmet need in inflammatory bowel disease is the lack of anti-fibrotic agents targeting intestinal fibrosis. This study aimed to investigate the anti-fibrogenic properties and mechanisms of the co...

    Authors: Yoon Jeong Choi, Woo Ram Kim, Duk Hwan Kim, Jee Hyun Kim and Jun Hwan Yoo
    Citation: Stem Cell Research & Therapy 2024 15:69
  17. Mesenchymal stem/stromal cells (MSCs) are of great therapeutic value due to their role in maintaining the function of hematopoietic stem/progenitor cells (HSPCs). MSCs derived from human pluripotent stem cells...

    Authors: Ya Zhou, Xinping Cai, Xiuxiu Zhang, Yong Dong, Xu Pan, Mowen Lai, Yimeng Zhang, Yijin Chen, Xiaohong Li, Xia Li, Jiaxin Liu, Yonggang Zhang and Feng Ma
    Citation: Stem Cell Research & Therapy 2024 15:68
  18. Spinal cord injury (SCI) is a serious clinical condition that has pathological changes such as increased neuroinflammation and nerve tissue damage, which eventually manifests as fibrosis of the injured segment...

    Authors: Xiaofeng Du, Desheng Kong, Ruiyun Guo, Boxin Liu, Jingjing He, Jinyu Zhang, Asiamah Ernest Amponsah, Huixian Cui and Jun Ma
    Citation: Stem Cell Research & Therapy 2024 15:67
  19. Mesenchymal stromal cells (MSCs) a potentially effective disease-modulating therapy for diabetic nephropathy (DN) but their clinical translation has been hampered by incomplete understanding of the optimal tim...

    Authors: Jingjing He, Boxin Liu, Xiaofeng Du, Yan Wei, Desheng Kong, Baofeng Feng, Ruiyun Guo, Ernest Amponsah Asiamah, Matthew D. Griffin, Sean O. Hynes, Sanbing Shen, Yan Liu, Huixian Cui, Jun Ma and Timothy O’Brien
    Citation: Stem Cell Research & Therapy 2024 15:66
  20. The multimodal properties of mesenchymal stromal cells (MSCs), particularly their ability to modulate immune responses is of high interest in translational research. Pro-inflammatory, hypoxic, and 3D culture p...

    Authors: Nick Herger, Irina Heggli, Tamara Mengis, Jan Devan, Leonardo Arpesella, Florian Brunner, Oliver Distler and Stefan Dudli
    Citation: Stem Cell Research & Therapy 2024 15:65
  21. Premature ovarian failure (POF) has a profound impact on female reproductive and psychological health. In recent years, the transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) has demons...

    Authors: Jiacheng Shen, Li Wu, Xiaoying Shi, Gang Chen, Tingwei Liu, Fangfang Xu, Xiaocui Xu, Xiaochen Kou, Yanhong Zhao, Hong Wang, Chenfei Wang, Shaorong Gao and Shaohua Xu
    Citation: Stem Cell Research & Therapy 2024 15:64
  22. Spinal ventral root avulsion results in massive motoneuron degeneration with poor prognosis and high costs. In this study, we compared different isoforms of basic fibroblast growth factor 2 (FGF2), overexpress...

    Authors: B. H. M. Lima, L. P. Cartarozzi, S. Kyrylenko, R. S. Ferreira Jr., B. Barraviera and Alexandre L. R. Oliveira
    Citation: Stem Cell Research & Therapy 2024 15:63
  23. Striae distensae is a disfiguring atrophic skin condition that impairs the body’s aesthetic image. Despite the variety of conducted studies, there is controversy regarding the best modalities. Human mesenchyma...

    Authors: Elham Behrangi, Masoomeh Feizollahi, Sona Zare, Azadeh Goodarzi, Mohammad Reza Ghasemi, Afsaneh Sadeghzadeh-Bazargan, Abbas Dehghani, Maryam Nouri, Roya Zeinali, Masoomeh Roohaninasab and Mohammad Ali Nilforoushzadeh
    Citation: Stem Cell Research & Therapy 2024 15:62
  24. Mesenchymal stromal cells (MSCs) are increasingly employed in regenerative medicine approaches for their immunomodulatory and anti-inflammatory properties, which are encoded in their secretome including extrac...

    Authors: Alexander Otahal, Karina Kramer, Markus Neubauer, Slavomira Gulová, Zsombor Lacza, Stefan Nehrer and Andrea De Luna
    Citation: Stem Cell Research & Therapy 2024 15:61
  25. The diarylheptanoid ASPP 049 has improved the quality of adult hematopoietic stem cell (HSC) expansion ex vivo through long-term reconstitution in animal models. However, its effect on hematopoietic regenerati...

    Authors: Umnuaychoke Thongsa-ad, Anongnat Wongpan, Wasinee Wongkummool, Phaewa Chaiwijit, Kwanchanok Uppakara, Gorawin Chaiyakitpattana, Passanan Singpant, Pirut Tong-ngam, Amnat Chukhan, Wachirachai Pabuprappap, Sirapope Wongniam, Apichart Suksamrarn, Suradej Hongeng, Usanarat Anurathapan, Kasem Kulkeaw, Alisa Tubsuwan…
    Citation: Stem Cell Research & Therapy 2024 15:60
  26. Pericytes are multifunctional contractile cells that reside on capillaries. Pericytes are critical regulators of cerebral blood flow and blood–brain barrier function, and pericyte dysfunction may contribute to...

    Authors: Natalie E. King, Jo-Maree Courtney, Lachlan S. Brown, Alastair J. Fortune, Nicholas B. Blackburn, Jessica L. Fletcher, Jake M. Cashion, Jana Talbot, Alice Pébay, Alex W. Hewitt, Gary P. Morris, Kaylene M. Young, Anthony L. Cook and Brad A. Sutherland
    Citation: Stem Cell Research & Therapy 2024 15:59
  27. Currently, no approved stem cell-based therapies for preserving ovarian function during aging. To solve this problem, we developed a long-term treatment for human embryonic stem cell-derived mesenchymal progen...

    Authors: Eun-Young Shin, Suji Jeong, Jeoung Eun Lee, Dong Seok Jeong, Dong Keun Han, Seok-Ho Hong and Dong Ryul Lee
    Citation: Stem Cell Research & Therapy 2024 15:58
  28. Human induced pluripotent stem (iPS) cell-derived enterocyte-like cells (ELCs) are expected to be useful for evaluating the intestinal absorption and metabolism of orally administered drugs. However, it is dif...

    Authors: Tatsuya Inui, Yusei Uraya, Jumpei Yokota, Tomoki Yamashita, Kanae Kawai, Kentaro Okada, Yukiko Ueyama-Toba and Hiroyuki Mizuguchi
    Citation: Stem Cell Research & Therapy 2024 15:57
  29. Hyperactive coagulation might cause dangerous complications such as portal vein thrombosis and pulmonary embolism after mesenchymal stem/stromal cell (MSC) therapy. Tissue factor (TF), an initiator of the extr...

    Authors: Van T. Hoang, Duc Son Le, Duc M. Hoang, Trang Thi Kieu Phan, Lan Anh Thi Ngo, Trung Kien Nguyen, Viet Anh Bui and Liem Nguyen Thanh
    Citation: Stem Cell Research & Therapy 2024 15:56
  30. Neural stem cells (NSCs), especially human NSCs, undergo cellular senescence characterized by an irreversible proliferation arrest and loss of stemness after prolonged culture. While compelling correlative dat...

    Authors: Teng Guan, Ying Guo, Ting Zhou, Qiang Yu, Jingyi Sun, Baoliang Sun, Guohui Zhang and Jiming Kong
    Citation: Stem Cell Research & Therapy 2024 15:55
  31. Unlike in lower vertebrates, Müller glia (MG) in adult mammalian retinas lack the ability to reprogram into neurons after retinal injury or degeneration and exhibit reactive gliosis instead. Whether a transiti...

    Authors: Zhiyuan Yin, Lingling Ge, Zhe Cha, Hui Gao, Luodan A, Yuxiao Zeng, Xiaona Huang, Xuan Cheng, Kai Yao, Zui Tao and Haiwei Xu
    Citation: Stem Cell Research & Therapy 2024 15:54
  32. Authors: Zhenpeng Zhu, Jiayu Yang, Xing Ji, Zicheng Wang, Chengxiang Dai, Suke Li, Xuesong Li, Yajie Xie, Yudong Zheng, Jian Lin and Liqun Zhou
    Citation: Stem Cell Research & Therapy 2024 15:53

    The original article was published in Stem Cell Research & Therapy 2022 13:463

  33. Authors: Rodrigo Azevedo Loiola, Miguel García-Gabilondo, Alba Grayston, Paulina Bugno, Agnieszka Kowalska, Sophie Duban-Deweer, Eleonora Rizzi, Johan Hachani, Yasuteru Sano, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, Maciej Piotr Mazurek, Anna Rosell and Fabien Gosselet
    Citation: Stem Cell Research & Therapy 2024 15:50
  34. Clinically, hormone replacement therapy (HRT) is the main treatment for primary ovarian insufficiency (POI). However, HRT may increase the risk of both breast cancer and cardiovascular disease. Exosomes derive...

    Authors: Fangfang Dai, Hua Liu, Juan He, Jinglin Wu, Chaoyan Yuan, Ruiqi Wang, Mengqin Yuan, Dongyong Yang, Zhimin Deng, Linlin Wang, Yanqing Wang, Xiao Yang, Huiling Wang, Wei Hu and Yanxiang Cheng
    Citation: Stem Cell Research & Therapy 2024 15:49
  35. Allogeneic hepatocyte transplantation is an emerging approach to treat acute liver defects. However, durable engraftment of the transplanted cells remains a daunting task, as they are actively cleared by the r...

    Authors: Nasir Abbas, Kai You, Anteneh Getachew, Feima Wu, Muzammal Hussain, Xinping Huang, Yan Chen, Tingcai Pan and Yinxiong Li
    Citation: Stem Cell Research & Therapy 2024 15:48
  36. Authors: Han Shen, Guanghao Cui, Yanqiong Li, Wenxue Ye, Yimin Sun, Zihan Zhang, Jingjing Li, Guiying Xu, Xiansheng Zeng, Yanxia Zhang, Wencheng Zhang, Zan Huang, Weiqian Chen and Zhenya Shen
    Citation: Stem Cell Research & Therapy 2024 15:47

    The original article was published in Stem Cell Research & Therapy 2019 10:17

  37. Radiotherapy in head and neck cancer management causes degeneration of the salivary glands (SG). This study was designed to determine the potential of gingival mesenchymal stem cells (GMSCs) as a cell-based th...

    Authors: Hagar M. Zayed, Nevine H. Kheir El Din, Ashraf M. Abu-Seida, Asmaa A. Abo Zeid and Ola M. Ezzatt
    Citation: Stem Cell Research & Therapy 2024 15:46
  38. Mesenchymal stem cells (MSCs) are attracting attention as a promising cell-based therapy for the treatment of liver fibrosis or cirrhosis. However, the strategies and potential mechanisms of MSCs therapy need ...

    Authors: Fan Ding, Yuting Liu, Jia Li, Xiao Wei, Jiangdong Zhao, Xiaojing Liu and Liqiang Zhang
    Citation: Stem Cell Research & Therapy 2024 15:44
  39. Ischemia–reperfusion injury to the central nervous system often causes severe complications. The activation of endogenous neural stem cells (NSCs) is considered a promising therapeutic strategy for nerve repai...

    Authors: Shaoqiong Zhang, Kaile Cui, Yuanyuan Li, Yiting Fan, Dongxu Wang, Xingen Yao and Bo Fang
    Citation: Stem Cell Research & Therapy 2024 15:43
  40. Corneal alkali burns can lead to ulceration, perforation, and even corneal blindness due to epithelial defects and extensive cell necrosis, resulting in poor healing outcomes. Previous studies have found that ...

    Authors: Zibo Wang, Changqing Jiang, Yuqiao Fan, Xiaodan Hao, Yanhan Dong, Xinjia He, Jinning Gao, Yongchun Zhang, Meng Li, Mengyuan Wang, Yiming Liu and Wenhua Xu
    Citation: Stem Cell Research & Therapy 2024 15:41
  41. Authors: Armin Attar, Mohsen Farjoud Kouhanjani, Kamran Hessami, Massoud Vosough, Javad Kojuri, Mani Ramzi, Seyed Ali Hosseini, Marjan Faghih and Ahmad Monabati
    Citation: Stem Cell Research & Therapy 2024 15:40

    The original article was published in Stem Cell Research & Therapy 2023 14:264

  42. Authors: Juan M. Ocampo-Godinez, Jose L. Gonzalez-Quiroz, Hector Cote-Palafox, Elizabeth George, Jael A. Vergara-Lope Nuñez, Guillermo Villagomez-Olea, Febe C. Vazquez-Vazquez, Edgar O. Lopez-Villegas, Gloria Leon-Avila, Maria L. Dominguez-Lopez and Marco A. Alvarez-Perez
    Citation: Stem Cell Research & Therapy 2024 15:39

    The original article was published in Stem Cell Research & Therapy 2023 14:312

  43. Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) plays a pivotal role in inducing metabolic inflammation in diabetes. Additionally, the NOD1 ligand disrupts the equilibrium of bone marrow-...

    Authors: Jingwen Qiu, Jing Wu, Wenwen Chen, Yu Ruan, Jingning Mao, Shue Li, Xuan Tang, Lei Zhao, Shengbing Li, Ke Li, Dongfang Liu and Yaqian Duan
    Citation: Stem Cell Research & Therapy 2024 15:38
  44. Adipose-derived stem cells (ASCs) are a critical adult stem cell subpopulation and are widely utilized in the fields of regenerative medicine and stem cell research due to their abundance, ease of harvest, and...

    Authors: Tianyi Sun, Cheng Zhou, Feng Lu, Ziqing Dong, Jianhua Gao and Bin Li
    Citation: Stem Cell Research & Therapy 2024 15:37
  45. Pericytes (PCs) are multipotent contractile cells that wrap around the endothelial cells (ECs) to maintain the blood vessel's functionality and integrity. The hyperglycemia associated with Type 2 diabetes mell...

    Authors: Toka A. Ahmed, Sara M. Ahmed, Hoda Elkhenany, Mohamed A. El-Desouky, Sameh Magdeldin, Aya Osama, Ali Mostafa Anwar, Ihab K. Mohamed, Mohamed Essameldin Abdelgawad, Demiana H. Hanna and Nagwa El-Badri
    Citation: Stem Cell Research & Therapy 2024 15:36
  46. The neuronal transdifferentiation of adult bone marrow cells (BMCs) is still considered an artifact based on an alternative explanation of experimental results supporting this phenomenon obtained over decades....

    Authors: Carlos Bueno, David García-Bernal, Salvador Martínez, Miguel Blanquer and José M. Moraleda
    Citation: Stem Cell Research & Therapy 2024 15:32

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