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  1. This arcticle has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13287-016-0438-5.

    Authors: Lihui Yu, Ying Lu, Xiaocui Han, Wenyue Zhao, Jiazhi Li, Jun Mao, Bo Wang, Jie Shen, Shujun Fan, Lu Wang, Mei Wang, Lianhong Li, Jianwu Tang and Bo Song

    Citation: Stem Cell Research & Therapy 2021 12:136

    Content type: Retraction Note

    Published on:

    The original article was published in Stem Cell Research & Therapy 2016 7:180

  2. Authors: Virginie Neirinckx, Gulistan Agirman, Cécile Coste, Alice Marquet, Valérie Dion, Bernard Rogister, Rachelle Franzen and Sabine Wislet

    Citation: Stem Cell Research & Therapy 2021 12:135

    Content type: Editor's Note

    Published on:

    The Research to this article has been published in Stem Cell Research & Therapy 2015 6:211

  3. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yifeng Ke, Xiaoe Fan, Rui Hao, Lijie Dong, Min Xue, Liangzhang Tan, Chunbo Yang, Xiaorong Li and Xinjun Ren

    Citation: Stem Cell Research & Therapy 2021 12:134

    Content type: Correction

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    The original article was published in Stem Cell Research & Therapy 2021 12:21

  4. The purpose of this study was to investigate the therapeutic effects of genetically modified mesenchymal stem cells (MSCs) in the treatment of type 2 diabetes mellitus (T2DM) in order to identify a new method ...

    Authors: Binghua Xue, Xiuxiao Xiao, Tingting Yu, Xinhua Xiao, Jing Xie, Qiuhe Ji, Li Wang, Tao Na, Shufang Meng, Lingjia Qian and Haifeng Duan

    Citation: Stem Cell Research & Therapy 2021 12:133

    Content type: Research

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  5. Bone morphogenetic protein 2 (BMP2) is a promising chondrogenic growth factor for cartilage tissue-engineering, but it also induces robust endochondral ossification. Human synovial-derived mesenchymal stromal ...

    Authors: Pengcheng Xiao, Zhenglin Zhu, Chengcheng Du, Yongsheng Zeng, Junyi Liao, Qiang Cheng, Hong Chen, Chen Zhao and Wei Huang

    Citation: Stem Cell Research & Therapy 2021 12:132

    Content type: Research

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  6. Duchenne muscular dystrophy (DMD) is caused by mutations of the gene that encodes the protein dystrophin. A loss of dystrophin leads to severe and progressive muscle wasting in both skeletal and heart muscles....

    Authors: Wanling Xuan, Mahmood Khan and Muhammad Ashraf

    Citation: Stem Cell Research & Therapy 2021 12:131

    Content type: Research

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  7. Thin endometrium adversely affects reproductive success rates with fertility treatment. Autologous transplantation of exogenously prepared endometrium can be a promising therapeutic option for thin endometrium...

    Authors: Ryo Yokomizo, Yukiko Fujiki, Harue Kishigami, Hiroshi Kishi, Tohru Kiyono, Sanae Nakayama, Haruhiko Sago, Aikou Okamoto and Akihiro Umezawa

    Citation: Stem Cell Research & Therapy 2021 12:130

    Content type: Research

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  8. The repair of large-scale full-thickness skin defects represents a challenging obstacle in skin tissue engineering. To address the most important problem in skin defect repair, namely insufficient blood supply...

    Authors: Shuang Lin, Xiaoning He and Yuanjia He

    Citation: Stem Cell Research & Therapy 2021 12:129

    Content type: Research

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  9. Recently, growing evidence has indicated an important role of the complement system, a crucial component of immunity, in mediating neuroinflammation and promoting neuronal apoptosis following closed head injur...

    Authors: Mou Gao, Qin Dong, Wenjia Wang, Zhijun Yang, Lili Guo, Yingzhou Lu, Boyun Ding, Lihua Chen, Jianning Zhang and Ruxiang Xu

    Citation: Stem Cell Research & Therapy 2021 12:128

    Content type: Research

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  10. Extracellular vesicles (EVs) produced by human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) are currently investigated for their clinical effectiveness towards immune-mediated diseases. The large a...

    Authors: Jonathan Gobin, Gauri Muradia, Jelica Mehic, Carole Westwood, Lauren Couvrette, Andrew Stalker, Stewart Bigelow, Christian C. Luebbert, Frédéric St-Denis Bissonnette, Michael J. W. Johnston, Simon Sauvé, Roger Y. Tam, Lisheng Wang, Michael Rosu-Myles and Jessie R. Lavoie

    Citation: Stem Cell Research & Therapy 2021 12:127

    Content type: Research

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  11. Cancer is a leading cause of death in both developed and developing countries, and because of population growth and aging, it is a growing medical burden worldwide. With robust development in medicine, the use...

    Authors: Ameneh Jafari, Mostafa Rezaei-Tavirani, Behrouz Farhadihosseinabadi, Hakimeh Zali and Hassan Niknejad

    Citation: Stem Cell Research & Therapy 2021 12:126

    Content type: Review

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  12. Stroke serves as a prevalent cerebrovascular disorder with severe cerebral ischemia/reperfusion (CIR) injury, in which neural stem cells (NSCs) play critical roles in the recovery of cerebral function. Circula...

    Authors: Bo Yang, Li’e Zang, Jingwen Cui and Linlin Wei

    Citation: Stem Cell Research & Therapy 2021 12:125

    Content type: Research

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  13. Mesenchymal stromal cells (MSCs) constitute one of the cell types most frequently used in cell therapy. Although several studies have shown the efficacy of these cells to modulate inflammation in different ani...

    Authors: Rosario Hervás-Salcedo, María Fernández-García, Miriam Hernando-Rodríguez, Oscar Quintana-Bustamante, Jose-Carlos Segovia, Marcio Alvarez-Silva, Mariano García-Arranz, Pablo Minguez, Victoria del Pozo, Marta Rodríguez de Alba, Damián García-Olmo, Carmen Ayuso, María Luisa Lamana, Juan A. Bueren and Rosa María Yañez

    Citation: Stem Cell Research & Therapy 2021 12:124

    Content type: Research

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  14. To repair bone defects, a variety of bone substitution materials have been used, such as ceramics, metals, natural and synthetic polymers, and combinations thereof. In recent decades, a wide range of synthetic...

    Authors: Siyi Wang, Rong Li, Dandan Xia, Xiao Zhao, Yuan Zhu, Ranli Gu, Jungmin Yoon and Yunsong Liu

    Citation: Stem Cell Research & Therapy 2021 12:123

    Content type: Review

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  15. This research is the first to produce induced pluripotent stem cell-derived inner ear sensory neurons in the Neurog1+/− heterozygote mouse using blastocyst complementation. Additionally, this approach corrected n...

    Authors: Aleta R. Steevens, Matthew W. Griesbach, Yun You, James R. Dutton, Walter C. Low and Peter A. Santi

    Citation: Stem Cell Research & Therapy 2021 12:122

    Content type: Short report

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  16. Diabetic osteoporosis (DOP) is a systemic metabolic bone disease caused by diabetes mellitus (DM). Adipose-derived stem cells (ASCs) play an important role in bone regeneration. Our previous study confirmed th...

    Authors: Shuanglin Peng, Sirong Shi, Gang Tao, Yanjing Li, Dexuan Xiao, Lang Wang, Qing He, Xiaoxiao Cai and Jingang Xiao

    Citation: Stem Cell Research & Therapy 2021 12:120

    Content type: Research

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  17. Tumor-associated antigens (TAAs) can be targeted in cancer therapy. We previously identified a monoclonal antibody (mAb) 12C7, which presented anti-tumor activity in lung cancer stem cells (LCSCs). Here, we ai...

    Authors: Xiong Shu, Kai-Yue Cao, Hui-Qi Liu, Long Yu, Li-Xin Sun, Zhi-Hua Yang, Cheng-Ai Wu and Yu-Liang Ran

    Citation: Stem Cell Research & Therapy 2021 12:119

    Content type: Research

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  18. Oligovascular niche mediates interactions between cerebral endothelial cells and oligodendrocyte precursor cells (OPCs). Disruption of OPC-endothelium trophic coupling may aggravate the progress of cerebral wh...

    Authors: Ning Zhou, Lei Wang, Ping Fu, Zihao Cui, Yuhang Ge, Feiyu Jiang, Jing Liu, Chao Ren, Zuo Luan, Hongbin Fan and Ruiqin Yao

    Citation: Stem Cell Research & Therapy 2021 12:118

    Content type: Research

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  19. Although exosomes, as byproducts of human umbilical cord mesenchymal stem cells (hUC-MSCs), have been demonstrated to be an effective therapy for traumatic spinal cord injury (SCI), their mechanism of action r...

    Authors: Yang Wang, Xunwei Lai, Depeng Wu, Bin Liu, Nanxiang Wang and Limin Rong

    Citation: Stem Cell Research & Therapy 2021 12:117

    Content type: Research

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  20. Combination of mesenchymal stem cells (MSCs) and biomaterials is a rapidly growing approach in regenerative medicine particularly for chronic degenerative disorders including osteoarthritis and osteoporosis. T...

    Authors: Mohamed I. Elashry, Nadine Baulig, Alena-Svenja Wagner, Michele C. Klymiuk, Benjamin Kruppke, Thomas Hanke, Sabine Wenisch and Stefan Arnhold

    Citation: Stem Cell Research & Therapy 2021 12:116

    Content type: Research

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  21. Mesenchymal stem cells (MSCs) are favourable treatments for ischaemic diseases; however, MSCs from diabetic patients are not useful for this purpose. Recent studies have shown that the expression of miR-34a is...

    Authors: Fengyun Zhang, Fei Gao, Kun Wang, Xiaohong Liu and Zhuoqi Zhang

    Citation: Stem Cell Research & Therapy 2021 12:115

    Content type: Research

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  22. Retarded wound healing in patients with obesity contributes to a risk of complications associated with vascular insufficiency and oxidative stress. The high cholesterol levels of patients with obesity are asso...

    Authors: Jun Sung Kim, Young Hyun Jung, Hyun Jik Lee, Chang Woo Chae, Gee Euhn Choi, Jae Ryong Lim, Seo Yihl Kim, Joo Eun Lee and Ho Jae Han

    Citation: Stem Cell Research & Therapy 2021 12:114

    Content type: Research

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  23. Despite recent rapid progress in method development and biological understanding of induced pluripotent stem (iPS) cells, there has been a relative shortage of tools that monitor the early reprogramming proces...

    Authors: Sandhya Sriram, Nam-Young Kang, Subha Subramanian, Tannistha Nandi, Samydurai Sudhagar, Qiaorui Xing, Gerine Jin-Ling Tong, Allen Kuan-Liang Chen, Thekkeparambil Chandrabose Srijaya, Patrick Tan, Yuin-Han Loh, Young-Tae Chang and Shigeki Sugii

    Citation: Stem Cell Research & Therapy 2021 12:113

    Content type: Method

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  24. Nicotinamide phosphoribosyltransferase (NAMPT) regulates cellular functions through the protein deacetylation activity of nicotinamide adenine dinucleotide (NAD+)-dependent sirtuins (SIRTs). SIRTs regulate functi...

    Authors: Yun Xu, Masoud Nasri, Benjamin Dannenmann, Perihan Mir, Azadeh Zahabi, Karl Welte, Tatsuya Morishima and Julia Skokowa

    Citation: Stem Cell Research & Therapy 2021 12:112

    Content type: Research

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  25. Cerebral ischemia-reperfusion (I/R) injury, the most common form of stroke, has high mortality and often brings persistent and serious brain dysfunction among survivors. Administration of adipose-derived mesen...

    Authors: Yamei Zhang, Junying Liu, Mi Su, Xin Wang and Chenchen Xie

    Citation: Stem Cell Research & Therapy 2021 12:111

    Content type: Research

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  26. Novel therapeutic strategies for the healing of nonunion, which has serious effects on the quality of life of patients, are needed. We evaluated the therapeutic effect of local transplantation of human stromal...

    Authors: Tomoyuki Kamenaga, Yuichi Kuroda, Kanto Nagai, Masanori Tsubosaka, Yoshinori Takashima, Kenichi Kikuchi, Masahiro Fujita, Kemmei Ikuta, Kensuke Anjiki, Toshihisa Maeda, Naoki Nakano, Koji Takayama, Shingo Hashimoto, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura…

    Citation: Stem Cell Research & Therapy 2021 12:110

    Content type: Research

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  27. Effective stem cell therapy is dependent on the stem cell quality that is determined by their differentiation potential, impairment of which leads to poor engraftment and survival into the target cells. Howeve...

    Authors: Smarajit Chakraborty, Wee Kiat Ong, Winifred W. Y. Yau, Zhihong Zhou, K. N. Bhanu Prakash, Sue-Anne Toh, Weiping Han, Paul M. Yen and Shigeki Sugii

    Citation: Stem Cell Research & Therapy 2021 12:109

    Content type: Research

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  28. Bone fracture repair has gained a lot of attention due to the high incidence of delayed union or even nonunion especially in osteoporotic patients, resulting in a dreadful impact on the quality of life. Howeve...

    Authors: Liang Chen, Ri-Yan Zhang, Jun Xie, Jia-Yi Yang, Kang-Hao Fang, Chen-Xuan Hong, Rong-Bo Yang, Najeeb Bsoul and Lei Yang

    Citation: Stem Cell Research & Therapy 2021 12:108

    Content type: Research

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  29. A large number of preclinical studies have shown that local anesthetics have a direct inhibitory effect on tumor biological activities, including cell survival, proliferation, migration, and invasion. There ar...

    Authors: Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Lizhu Hu, Delong Wang, Ruiting Wang, Zhiyou Fang and Xueran Chen

    Citation: Stem Cell Research & Therapy 2021 12:107

    Content type: Research

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  30. Mesenchymal stromal cells (MSCs) are an emerging prophylaxis option for graft-versus-host disease (GVHD) in haplo-identical hematopoietic stem cell transplantation (haplo-HSCT) recipients with severe aplastic ...

    Authors: Ruonan Li, Jingke Tu, Jingyu Zhao, Hong Pan, Liwei Fang and Jun Shi

    Citation: Stem Cell Research & Therapy 2021 12:106

    Content type: Research

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  31. Multipotent mesenchymal stromal cells (MSCs) are potentially therapeutic for muscle disease because they can accumulate at the sites of injury and act as immunosuppressants. MSCs are attractive candidates for ...

    Authors: Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Yuki Oda, Hiromi Hayashita-Kinoh, Shin’ichi Takeda and Takashi Okada

    Citation: Stem Cell Research & Therapy 2021 12:105

    Content type: Research

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  32. This study aimed to explore the effect of KAT6A on the decreased stemness of aging bone marrow-derived mesenchymal stem cells (BMSCs) and its potential mechanism.

    Authors: Dongdong Fei, Yazheng Wang, Qiming Zhai, Xige Zhang, Yang Zhang, Yang Wang, Bei Li and Qintao Wang

    Citation: Stem Cell Research & Therapy 2021 12:104

    Content type: Research

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  33. The autoimmune diseases are characterized by overactivation of immune cells, chronic inflammation, and immune response to self-antigens, leading to the damage and dysfunction of multiple organs. Patients still...

    Authors: Chao Yang, Mingjun Wu, Min You, Yu Chen, Maowen Luo and Qiang Chen

    Citation: Stem Cell Research & Therapy 2021 12:103

    Content type: Review

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  34. Spinal cord injury (SCI) often leads to serious motor and sensory dysfunction of the limbs below the injured segment. SCI not only results in physical and psychological harm to patients but can also cause a hu...

    Authors: Wen-zhao Liu, Zhan-jun Ma, Jie-ru Li and Xue-wen Kang

    Citation: Stem Cell Research & Therapy 2021 12:102

    Content type: Review

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  35. Distraction osteogenesis (DO) is a highly efficacious form of reconstructive bone regeneration, but its clinical utility is limited by the prolonged period required for bone consolidation to occur. Understandi...

    Authors: Weidong Jiang, Peiqi Zhu, Tao Zhang, Fengchun Liao, Yangyang Yu, Yan Liu, Huijuan Shen, Zhenchen Zhao, Xuanping Huang and Nuo Zhou

    Citation: Stem Cell Research & Therapy 2021 12:101

    Content type: Research

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  36. Secretome profiles of mesenchymal stem cells (MSCs) are reflective of their local microenvironments. These biologically active factors exert an impact on the surrounding cells, eliciting regenerative responses...

    Authors: Nurul Dinah Kadir, Zheng Yang, Afizah Hassan, Vinitha Denslin and Eng Hin Lee

    Citation: Stem Cell Research & Therapy 2021 12:100

    Content type: Research

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  37. Reendothelialisation is the natural pathway that inhibits neointimal hyperplasia and in-stent restenosis. Circulating endothelial progenitor cells (EPCs) derived from bone marrow (BM) might contribute to endot...

    Authors: Wei Wang, Yingqian Zhang, Hui Hui, Wei Tong, Zechen Wei, Zhongxuan Li, Suhui Zhang, Xin Yang, Jie Tian and Yundai Chen

    Citation: Stem Cell Research & Therapy 2021 12:99

    Content type: Research

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  38. Human periodontal ligament stem cells (hPDLSCs) are ideal seed cells for periodontal regeneration. A greater understanding of the dynamic protein profiles during osteogenic differentiation contributed to the i...

    Authors: Jianjia Li, Zhifa Wang, Xiangyu Huang, Zhaodan Wang, Zehao Chen, Runting Wang, Zhao Chen, Wei Liu, Buling Wu, Fuchun Fang and Wei Qiu

    Citation: Stem Cell Research & Therapy 2021 12:98

    Content type: Research

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  39. Protein tyrosine phosphatase 1B (PTP1B) is one of the major negative regulators of leptin and insulin signaling, and has been strongly implicated in insulin resistance development in the course of obesity and ...

    Authors: Lynda Bourebaba, Katarzyna Kornicka-Garbowska, Mohamad Al Naem, Michael Röcken, Jacek Łyczko and Krzysztof Marycz

    Citation: Stem Cell Research & Therapy 2021 12:97

    Content type: Research

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  40. Previous reports have identified that human bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) with their cargo microRNAs (miRNAs) are a promising therapeutic approach for the treatmen...

    Authors: Jing Zhou, Yang Lin, Xiuhua Kang, Zhicheng Liu, Wei Zhang and Fei Xu

    Citation: Stem Cell Research & Therapy 2021 12:96

    Content type: Research

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  41. Organoids are derived from stem cells or organ-specific progenitors. They display structures and functions consistent with organs in vivo. Multiple types of organoids, including lung organoids, can be generate...

    Authors: Jing Kong, Shiyuan Wen, Wenjing Cao, Peng Yue, Xin Xu, Yu Zhang, Lisha Luo, Taigui Chen, Lianbao Li, Feng Wang, Jian Tao, Guozhong Zhou, Suyi Luo, Aihua Liu and Fukai Bao

    Citation: Stem Cell Research & Therapy 2021 12:95

    Content type: Review

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  42. The long-term survival after vascularized composite allotransplantation (VCA) is often limited by systemic rejection as well as the adverse effects of immunosuppressants. The stromal vascular fraction (SVF) ca...

    Authors: Jingting Chen, Yinmin Wang, Haoyue Hu, Yao Xiong, Shoubao Wang and Jun Yang

    Citation: Stem Cell Research & Therapy 2021 12:94

    Content type: Research

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  43. Cell therapies present an exciting potential but there is a long history of expensive translational failures in stroke research. Researchers engaged in cell therapy research would benefit from a practical fram...

    Authors: Anjali Nagpal, Austin G. Milton, Simon A. Koblar and M. Anne Hamilton-Bruce

    Citation: Stem Cell Research & Therapy 2021 12:93

    Content type: Method

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  44. Dyskeratosis congenita (DC) is a rare telomere biology disorder, which results in different clinical manifestations, including severe bone marrow failure. To date, the only curative treatment for the bone marr...

    Authors: Carlos Carrascoso-Rubio, Hidde A. Zittersteijn, Laura Pintado-Berninches, Beatriz Fernández-Varas, M. Luz Lozano, Cristina Manguan-Garcia, Leandro Sastre, Juan A. Bueren, Rosario Perona and Guillermo Guenechea

    Citation: Stem Cell Research & Therapy 2021 12:92

    Content type: Short report

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  45. Acute respiratory distress syndrome (ARDS) is a fatal complication of coronavirus disease 2019 (COVID-19). There are a few reports of allogeneic human mesenchymal stem cells (MSCs) as a potential treatment for...

    Authors: Seyed-Mohammad Reza Hashemian, Rasoul Aliannejad, Morteza Zarrabi, Masoud Soleimani, Massoud Vosough, Seyedeh-Esmat Hosseini, Hamed Hossieni, Saeid Heidari Keshel, Zeinab Naderpour, Ensiyeh Hajizadeh-Saffar, Elham Shajareh, Hamidreza Jamaati, Mina Soufi-Zomorrod, Naghmeh Khavandgar, Hediyeh Alemi, Aliasghar Karimi…

    Citation: Stem Cell Research & Therapy 2021 12:91

    Content type: Research

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  46. Ischemia-reperfusion injury (IRI) is an important factor limiting the success of cardiac reperfusion therapy. Curcumin has a significant cardioprotective effect against IRI, can inhibit ventricular remodeling ...

    Authors: Chi-Lin Liao, Yang Liu, Meng-Zhao Huang, Hua-Yong Liu, Zi-Liang Ye and Qiang Su

    Citation: Stem Cell Research & Therapy 2021 12:89

    Content type: Research

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  47. Tissue engineered and regenerative approaches for treating tendon injuries are challenged by the limited information on the cellular signaling pathways driving tenogenic differentiation of stem cells. Members ...

    Authors: Sophia K. Theodossiou, Jett B. Murray, LeeAnn A. Hold, Jeff M. Courtright, Anne M. Carper and Nathan R. Schiele

    Citation: Stem Cell Research & Therapy 2021 12:88

    Content type: Research

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  48. Patients with peripheral nerve injury (PNI) often suffer from hypoxic ischemic impairments, in particular when combined with vascular damage, causing neuronal dysfunction and death. Increasing attention has be...

    Authors: Meng Cong, Mi Shen, Xia Wu, Yan Li, Liting Wang, Qianru He, Haiyan Shi and Fei Ding

    Citation: Stem Cell Research & Therapy 2021 12:80

    Content type: Research

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