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  1. Vascular dementia (VD) results in cognition and memory deficit. Exosomes and their carried microRNAs (miRs) contribute to the neuroprotective effects of mesenchymal stromal cells, and miR-132-3p plays a key ro...

    Authors: Xiaotang Ma, Yan Wang, Yumeng Shi, Suqing Li, Jinhua Liu, Xiangyong Li, Wangtao Zhong and Qunwen Pan
    Citation: Stem Cell Research & Therapy 2022 13:315
  2. The biological activity and regenerative medicine of bone marrow mesenchymal stem cells (BMSCs) have been focal topics in the broad fields of diabetic wound repair. However, the molecular mechanisms are still ...

    Authors: Yan Shi, Shang Wang, Weiwei Zhang, Yihan Zhu, Zhiqiang Fan, Yuesheng Huang, Furong Li and Ronghua Yang
    Citation: Stem Cell Research & Therapy 2022 13:314
  3. Acute compartment syndrome (ACS), a well-known complication of musculoskeletal injury, results in muscle necrosis and cell death. Embryonic stem cell-derived mesenchymal stem cells (ESC-MSCs) have been shown t...

    Authors: Xiangkang Jiang, Jingyuan Yang, Fei Liu, Jiawei Tao, Jiefeng Xu and Mao Zhang
    Citation: Stem Cell Research & Therapy 2022 13:313
  4. Elucidating the mechanism of odontogenic differentiation of human dental pulp stem cells (hDPSCs) is the key to in-depth mastery and development of regenerative endodontic procedures (REPs). In odontogenic dif...

    Authors: Tingting Fu, Yiran Liu, Xin Huang, Yan Guo, Jiaping Shen and Hong Shen
    Citation: Stem Cell Research & Therapy 2022 13:311
  5. Tracheal fistulas (TF) can be dangerous and even fatal in patients. The current treatment is really challenging. Previous studies reported that mesenchymal stem cells (MSCs) could be used to treat respiratory ...

    Authors: Fang Wang, Zhangwen Li, Feng-Juan Lyu, Jie Gao, Jinle Lin, Jianling Liu, Xiaowen Chen, Zhongpeng Li, Jiajie Shan and Jian Wu
    Citation: Stem Cell Research & Therapy 2022 13:310
  6. Liver fibrosis is a wound-healing process that occurs in response to severe injuries and is hallmarked by the excessive accumulation of extracellular matrix or scar tissues within the liver. Liver fibrosis can...

    Authors: Lichao Yao, Xue Hu, Kai Dai, Mengqin Yuan, Pingji Liu, Qiuling Zhang and Yingan Jiang
    Citation: Stem Cell Research & Therapy 2022 13:308
  7. Research on clinical trials that employ stem cells to treat children’s diseases is limited. The clinical trial registry database provides a unique window to us to get known about clinical trial researches with...

    Authors: Yinwen Ji, Chuan Hu, Zuxing Chen, Ying Li, Jiayong Dai, Jin Zhang and Qiang Shu
    Citation: Stem Cell Research & Therapy 2022 13:307
  8. High glucose-induced damage to the osteogenic differentiation of human periodontal ligament stem cells (PDLSCs) has long been a challenge to periodontal regeneration for diabetic individuals. Metformin is an a...

    Authors: Yi-Lin Zhang, Fen Liu, Zhi-Bang Li, Xiao-Tao He, Xuan Li, Rui-Xin Wu, Hai-Hua Sun, Shao-Hua Ge, Fa-Ming Chen and Ying An
    Citation: Stem Cell Research & Therapy 2022 13:305
  9. Human dental pulp stem cells (hDPSCs) have received widespread attention in the fields of tissue engineering and regenerative medicine. Although amphiregulin (AREG) has been shown to play a vital function in t...

    Authors: Junqing Li, Zhihua Wang, Juan Wang, Qian Guo, Yi Fu, Zihan Dai, Minghao Wang, Yu Bai, Xin Liu, Paul R. Cooper, Jiayuan Wu and Wenxi He
    Citation: Stem Cell Research & Therapy 2022 13:304
  10. Endometrial regenerative cells (ERCs) play an important role in attenuation of acute allograft rejection, while their effects are limited. IL-37, a newly discovered immunoregulatory cytokine of the IL-1 family...

    Authors: Hong Qin, Chenglu Sun, Yanglin Zhu, Yafei Qin, Shaohua Ren, Zhaobo Wang, Chuan Li, Xiang Li, Baoren Zhang, Jingpeng Hao, Guangming Li, Hongda Wang, Bo Shao, Jingyi Zhang and Hao Wang
    Citation: Stem Cell Research & Therapy 2022 13:302
  11. The fundamental cause of intrauterine adhesions (IUAs) is the destruction and reduction in stem cells in endometrial basal layer, resulting in endometrial reconstruction very difficult. The purpose of this stu...

    Authors: Qing Hua, Yong Zhang, Hongjuan Li, Haoran Li, Ranran Jin, Li Li, Yuancui Xiang, Meng Tian, Jingjing Wang, Lei Sun and Yali Wang
    Citation: Stem Cell Research & Therapy 2022 13:301
  12. Most castration-resistant prostate cancers (CRPCs) have a luminal phenotype with high androgen receptor (AR) and prostate-specific antigen (PSA) expression. Currently, it is difficult to culture castration-res...

    Authors: Yalan Xu, Jie Mu, Zhixia Zhou, Yu Leng, Yali Yu, Xiuyue Song, Aihua Liu, Hai Zhu, Jing Li and Dong Wang
    Citation: Stem Cell Research & Therapy 2022 13:299
  13. Acne is the most common skin disorder which is known as a chronic inflammatory disease with psychological burden and reduced quality of life. Adipose tissue-derived stromal vascular fraction (SVF) is recognize...

    Authors: Elham Behrangi, Sepideh Moradi, Mohammadreza Ghassemi, Azadeh Goodarzi, Amirreza Hanifnia, Sona Zare, Maryam Nouri, Abbas Dehghani, Azadeh Seifadini, Mohammad Ali Nilforoushzadeh and Masoumeh Roohaninasab
    Citation: Stem Cell Research & Therapy 2022 13:298
  14. As a leading cause of vision decline and severe blindness in adults, diabetic retinopathy (DR) is characterized by the aggravation of retinal oxidative stress and apoptosis in the early stage. Emerging studies...

    Authors: Fengtian Sun, Yuntong Sun, Junyan Zhu, Xiaoling Wang, Cheng Ji, Jiahui Zhang, Shenyuan Chen, Yifan Yu, Wenrong Xu and Hui Qian
    Citation: Stem Cell Research & Therapy 2022 13:293
  15. Improved understanding of the stemness regulation mechanism in intrahepatic cholangiocarcinoma (ICC) could identify targets and guidance for adjuvant transarterial chemoembolization (TACE).

    Authors: Lifeng Huang, Dongwei Xu, Yawei Qian, Xiaoqiang Zhang, Han Guo, Meng Sha, Rui Hu, Xiaoni Kong, Qiang Xia and Yi Zhang
    Citation: Stem Cell Research & Therapy 2022 13:292
  16. Spinal cord ischemia reperfusion injury (SCIRI) is a complication of aortic aneurysm repair or spinal cord surgery that is associated with permanent neurological deficits. Mesenchymal stem cell (MSC)-derived s...

    Authors: Xiao Lu, Chengtang Lv, Yuechao Zhao, Yufei Wang, Yao Li, Chengyue Ji, Zhuanghui Wang, Wu Ye, Shunzhi Yu, Jianling Bai and Weihua Cai
    Citation: Stem Cell Research & Therapy 2022 13:291
  17. To explore the function of phosphorylation of KAP1 (p-KAP1) at the serine-824 site (S824) in the proliferation and apoptosis of endogenous neural stem cells (NSCs) after cerebral ischemic/reperfusion (I/R).

    Authors: Wan Wang, Tianqing Yan, Xinjian Guo, Heng Cai, Chang Liang, Linyan Huang, Yanling Wang, Ping Ma and Suhua Qi
    Citation: Stem Cell Research & Therapy 2022 13:290
  18. Bone marrow cells (BMCs), especially mesenchymal stem cells (MSCs), have shown attractive application prospects in acute myocardial infarction (AMI). However, the weak efficacy becomes their main limitation in...

    Authors: Yuyan Xiong, Ruijie Tang, Junyan Xu, Wenyang Jiang, Zhaoting Gong, Lili Zhang, Yu Ning, Peisen Huang, Jun Xu, Guihao Chen, Xiaosong Li, Mengjin Hu, Jing Xu, Chunxiao Wu, Chen Jin, Xiangdong Li…
    Citation: Stem Cell Research & Therapy 2022 13:289
  19. α-1-syntrophin (SNTA1), a protein encoded by SNTA1, is highly expressed in human cardiomyocytes. Mutations in SNTA1 are associated with arrhythmia and cardiomyopathy. Previous research on SNTA1 has been based on ...

    Authors: Tao Dong, Yan Zhao, Hai-Feng Jin, Lei Shen, Yan Lin, Long-Long Si, Li Chen and Ji-Cheng Liu
    Citation: Stem Cell Research & Therapy 2022 13:288
  20. The slowly activated delayed rectifier potassium current (IKs) mediated by the KCNQ1 gene is one of the main currents involved in repolarization. KCNQ1 mutation can result in long-QT syndrome type 1 (LQT1). IKs d...

    Authors: Yuanxiu Song, Tianwei Guo, Youxu Jiang, Min Zhu, Hongyue Wang, Wenjing Lu, Mengqi Jiang, Man Qi, Feng Lan and Ming Cui
    Citation: Stem Cell Research & Therapy 2022 13:287
  21. Human dental pulp stem cells (hDPSCs) are critical for pulp generation. hDPSCs proliferate faster under hypoxia, but the mechanism by which long noncoding RNA (lncRNA) regulates this process is not fully under...

    Authors: Junkai Zeng, Ming Chen, Yeqing Yang and Buling Wu
    Citation: Stem Cell Research & Therapy 2022 13:286
  22. Aging causes astrocyte morphological degeneration and functional deficiency, which impairs neuronal functions. Until now, whether age-induced neuronal deficiency could be alleviated by engraftment of glial pro...

    Authors: Zhiqi Yang, Mingyue Gong, Tingliang Jian, Jin Li, Chuanyan Yang, Qinlong Ma, Ping Deng, Yuxia Wang, Mingzhu Huang, Haoyu Wang, Shaofan Yang, Xiaowei Chen, Zhengping Yu, Manxia Wang, Chunhai Chen and Kuan Zhang
    Citation: Stem Cell Research & Therapy 2022 13:285
  23. Glioblastoma (GBM) is a highly immunosuppressive and vascular malignant brain tumor. Current therapeutic strategies targeting tumor cells have limited efficacy because of the immunosuppressive microenvironment...

    Authors: Qing Zhang, Junwen Zhang, Peiwen Wang, Guidong Zhu, Guishan Jin and Fusheng Liu
    Citation: Stem Cell Research & Therapy 2022 13:284
  24. Acute respiratory distress syndrome (ARDS) is the devastating complication of the new COVID-19 pandemic, directly correlated with releasing large amounts of inflammatory cytokines. Due to their immunoregulator...

    Authors: Najmeh Kaffash Farkhad, Alireza Sedaghat, Hamidreza Reihani, Amir Adhami Moghadam, Ahmad Bagheri Moghadam, Nayereh Khadem Ghaebi, Mohammad Ali Khodadoust, Rashin Ganjali, Amir Reza Tafreshian and Jalil Tavakol-Afshari
    Citation: Stem Cell Research & Therapy 2022 13:283
  25. Hematopoietic stem cells are able to self-renew and differentiate into all blood cell lineages. Hematopoietic stem cell transplantation is a mainstay of life-saving therapy for hematopoietic malignancies and h...

    Authors: Ning Wang, Chuxin Chen, Yang Cheng, Yingjie Fu, Zhiyong Zhong, Yu Yang, Ling Lv, Honglin Chen, Jian Huang and Yuyou Duan
    Citation: Stem Cell Research & Therapy 2022 13:282
  26. Non-traumatic intracerebral hemorrhage is a highly destructive intracranial disease with high mortality and morbidity rates. The main risk factors for cerebral hemorrhage include hypertension, amyloidosis, vas...

    Authors: Jian-feng Zhou, Yu Xiong, Xiaodong Kang, Zhigang Pan, Qiangbin Zhu, Roland Goldbrunner, Lampis Stavrinou, Shu Lin, Weipeng Hu, Feng Zheng and Pantelis Stavrinou
    Citation: Stem Cell Research & Therapy 2022 13:281
  27. The aim of this study was to investigate safety of treating diabetic foot ulcers with a topically administered mesenchymal stem cell product.

    Authors: Jonas Askø Andersen, Anne Rasmussen, Marie Frimodt-Møller, Susanne Engberg, Esther Steeneveld, Klaus Kirketerp-Møller, Timothy O’Brien and Peter Rossing
    Citation: Stem Cell Research & Therapy 2022 13:280
  28. As a fatal interstitial lung disease, idiopathic pulmonary fibrosis (IPF) was characterized by the insidious proliferation of extracellular matrix (ECM)-producing mesenchymal cells. Recent studies have demonst...

    Authors: Xiaoyu Yang, Wei Sun, Xiaoyan Jing, Qian Zhang, Hui Huang and Zuojun Xu
    Citation: Stem Cell Research & Therapy 2022 13:279
  29. Oncostatin M receptor (OSMR), as one of the receptors for oncostatin M (OSM), has previously been shown to mediate the stimulatory role of OSM in osteoclastogenesis and bone resorption. However, it remains to ...

    Authors: Jie Zhou, Junying Yang, Yuan Dong, Yaru Shi, Endong Zhu, Hairui Yuan, Xiaoxia Li and Baoli Wang
    Citation: Stem Cell Research & Therapy 2022 13:278
  30. Hematopoietic stem cell transplantation (HSCT) is a standard therapy strategy for most malignant disorders in children. However, transplant-related pneumonia remains a major therapy challenge and mesenchymal s...

    Authors: Yuhua Qu, Xu Yang, Xiaohong Zhang, Shanshan Liu, Xiaoping Liu, Xiaodan Liu, Ailing Luo, Mansi Cai, Yaping Yan, Ling Xu and Hua Jiang
    Citation: Stem Cell Research & Therapy 2022 13:277
  31. Adipose-derived stem cell (ASC) has been considered as a desirable source for cell therapy. In contrast to combining scaffold materials with cells, ASCs can be fabricated into scaffold-free three-dimensional (...

    Authors: Jiashing Yu, Yi-Chiung Hsu, Jen-Kuang Lee and Nai-Chen Cheng
    Citation: Stem Cell Research & Therapy 2022 13:276
  32. Mesenchymal stromal cells (MSCs) therapy for acute respiratory distress syndrome (ARDS) is an emerging treatment, but most of the current trials of MSCs stay in the animal experimental stage, and the safety an...

    Authors: Jianbao Wang, Fenbin Luo, Ye Suo, Yuxin Zheng, Kaikai Chen, Deyuan You and Yuqi Liu
    Citation: Stem Cell Research & Therapy 2022 13:275
  33. Human erythropoiesis is a tightly regulated, multistep process encompassing the differentiation of hematopoietic stem cells (HSCs) toward mature erythrocytes. Cellular metabolism is an important regulator of c...

    Authors: Sudjit Luanpitpong, Xing Kang, Montira Janan, Kanjana Thumanu, Jingting Li, Pakpoom Kheolamai and Surapol Issaragrisil
    Citation: Stem Cell Research & Therapy 2022 13:274

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:396

  34. The damaged neuronal cells of adult mammalian lack the regenerative ability to replace the neuronal connections. Periodontal ligament stem cells (PDLSCs) are the promising source for neuroregenerative applicat...

    Authors: Fariba Mohebichamkhorami, Roya Fattahi, Zahra Niknam, Morteza Aliashrafi, Sahar Khakpour Naeimi, Samira Gilanchi and Hakimeh Zali
    Citation: Stem Cell Research & Therapy 2022 13:273
  35. Inflammatory bowel diseases, consisting of Crohn’s disease and ulcerative colitis constitute chronic inflammatory conditions that may compromise the whole gastrointestinal tract as well as the colonic mucosa. ...

    Authors: Rui Zhang, Qingqing Zhang, Yanni Chen, Qing Zhao, Bo Zhang, Ling Wang, Chungen Zhou, Qi Zhang, Kun Chen, Yuqing Zhang, Xiaotao Hou, Hao Chen, Xingyin Liu, Min Ni and Bin Jiang
    Citation: Stem Cell Research & Therapy 2022 13:272
  36. Severe ionizing radiation (IR)-induced intestinal injury associates with high mortality, which is a worldwide problem requiring urgent attention. In recent years, studies have found that the PHD-HIF signaling ...

    Authors: Zhenlan Feng, Qinshu Xu, Xiang He, Yuedong Wang, Lan Fang, Jianpeng Zhao, Ying Cheng, Cong Liu, Jicong Du and Jianming Cai
    Citation: Stem Cell Research & Therapy 2022 13:271
  37. Stem and progenitor cells (SPCs) possess self-remodeling ability and differentiation potential and are responsible for the regeneration and development of organs and tissue systems. However, the precise mechan...

    Authors: Sijia Wang, Liang Li, Christopher Cook, Yufei Zhang, Yumin Xia and Yale Liu
    Citation: Stem Cell Research & Therapy 2022 13:270
  38. Aging disturbs the skin morphology and function, manifested as thinned epithelium and impaired wound healing. As a major type of skin cells, epidermal stem cells (EpiSCs) are inevitably affected by aging. The ...

    Authors: Jiachen Sun, Hongqing Zhao, Chuan’an Shen, Shiyi Li, Wen Zhang, Jinglong Ma, Zhisheng Li, Ming Zhang and Jianqiu Yang
    Citation: Stem Cell Research & Therapy 2022 13:269
  39. Mesenchymal stem cells (MSCs) have been suggested as an appropriate source for diabetes cell-based therapies. The high proliferation and differentiation capacity of fetal MSCs and the role of fetal pancreatic-...

    Authors: Zahra Jabbarpour, Sajjad Aghayan, Babak Arjmand, Khadijeh Fallahzadeh, Sepideh Alavi-Moghadam, Bagher Larijani and Hamid Reza Aghayan
    Citation: Stem Cell Research & Therapy 2022 13:268
  40. Mesenchymal stem cells (MSCs) are a heterogeneous group of subpopulations with differentially expressed surface markers. CD146 + MSCs correlate with high therapeutic and secretory potency. However, their thera...

    Authors: Lin Zhang, Yang Sun, Xiao-Xu Zhang, Yu-Bin Liu, Hui-Yan Sun, Chu-Tse Wu, Feng-Jun Xiao and Li-Sheng Wang
    Citation: Stem Cell Research & Therapy 2022 13:267
  41. Endothelial colony forming cells (ECFCs), alone or in combination with mesenchymal stem cells, have been selected as potential therapeutic candidates for critical limb-threatening ischemia (CLTI), mainly for t...

    Authors: Marta Rojas-Torres, Ismael Sánchez-Gomar, Antonio Rosal-Vela, Lucía Beltrán-Camacho, Sara Eslava-Alcón, José Ángel Alonso-Piñeiro, Javier Martín-Ramírez, Rafael Moreno-Luna and Mª Carmen Durán-Ruiz
    Citation: Stem Cell Research & Therapy 2022 13:266
  42. This study tested whether two doses of human umbilical-derived mesenchymal stem cells (hUC-MSCs) were superior to one dose for protecting the brain against intracranial hemorrhage (ICH) induced by intracranial...

    Authors: Kuan-Hung Chen, Han-Tan Chai, Kun-Chen Lin, John Y. Chiang, Pei-Hsun Sung, Chih-Hung Chen and Hon-Kan Yip
    Citation: Stem Cell Research & Therapy 2022 13:265
  43. Type-1 diabetes (T1D) occurs following autoimmune-induced pancreatic beta cells death. Among several treatment modalities, mesenchymal stem cells (MSCs) transplantation is promising for autoimmune disorders du...

    Authors: Mahmoud Izadi, Anavasadat Sadr Hashemi Nejad, Maedeh Moazenchi, Safdar Masoumi, Ali Rabbani, Farzad Kompani, Amir Abbas Hedayati Asl, Fatemeh Abbasi Kakroodi, Neda Jaroughi, Mohammad Ali Mohseni Meybodi, Aria Setoodeh, Farzaneh Abbasi, Seyedeh Esmat Hosseini, Fatemeh Moeini Nia, Reza Salman Yazdi, Roghayeh Navabi…
    Citation: Stem Cell Research & Therapy 2022 13:264
  44. Peripheral nerve injuries (PNIs) remain one of the great clinical challenges because of their considerable long-term disability potential. Postnatal neural crest-derived multipotent stem cells, including gingi...

    Authors: Qunzhou Zhang, Justin C. Burrell, Jincheng Zeng, Faizan I. Motiwala, Shihong Shi, D. Kacy Cullen and Anh D. Le
    Citation: Stem Cell Research & Therapy 2022 13:263
  45. Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and asthma, are one of the most frequent causes of morbidity and mortality in the global. COPD is characterized by progressive loss o...

    Authors: Hossein Abbaszadeh, Farzaneh Ghorbani, Sanaz Abbaspour-Aghdam, Amin Kamrani, Hamed Valizadeh, Mehdi Nadiri, Armin Sadeghi, Karim Shamsasenjan, Farhad Jadidi-Niaragh, Leila Roshangar and Majid Ahmadi
    Citation: Stem Cell Research & Therapy 2022 13:262
  46. Endothelial damage is an initial step of macro- and micro-vasculature dysfunctions in diabetic patients, accounting for a high incidence of diabetic vascular complications, such as atherosclerosis, nephropathy...

    Authors: Yi Liu, Jingan Chen, Haowei Liang, Yueqin Cai, Xinyue Li, Li Yan, Li Zhou, Letian Shan and Hui Wang
    Citation: Stem Cell Research & Therapy 2022 13:258
  47. The most frequent biochemical defect of inherited mitochondrial disease is isolated complex I deficiency. There is no cure for this disorder, and treatment is mainly supportive. In this study, we investigated ...

    Authors: Tharsini Navaratnarajah, Marlen Bellmann, Annette Seibt, Ruchika Anand, Özer Degistirici, Roland Meisel, Ertan Mayatepek, Andreas Reichert, Fabian Baertling and Felix Distelmaier
    Citation: Stem Cell Research & Therapy 2022 13:256
  48. hPSC-derived endothelial and hematopoietic cells (ECs and HCs) are an interesting source of cells for tissue engineering. Despite their close spatial and temporal embryonic development, current hPSC differenti...

    Authors: Alejandra Vargas-Valderrama, Anne-Charlotte Ponsen, Morgane Le Gall, Denis Clay, Sébastien Jacques, Tudor Manoliu, Valérie Rouffiac, Karine Ser-le-Roux, Cyril Quivoron, Fawzia Louache, Georges Uzan, Maria-Teresa Mitjavila-Garcia, Estelle Oberlin and Hind Guenou
    Citation: Stem Cell Research & Therapy 2022 13:254
  49. Intravenous administration of mesenchymal stromal cells (MSCs) has an acknowledged competence of cardiac repair, despite a lack of systematic description of the underlying biological mechanisms. The lung, but ...

    Authors: Anan Huang, Yue Liu, Xin Qi, Shang Chen, Haoyan Huang, Jun Zhang, Zhibo Han, Zhong-Chao Han and Zongjin Li
    Citation: Stem Cell Research & Therapy 2022 13:253

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