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  2. Skeletal muscle has a remarkable regenerative capacity. However, extensive damage that exceeds the self-regenerative ability of the muscle can lead to irreversible fibrosis, scarring, and significant loss of f...

    Authors: Agata Gorecka, Souzan Salemi, Deana Haralampieva, Federica Moalli, Deborah Stroka, Daniel Candinas, Daniel Eberli and Lukas Brügger
    Citation: Stem Cell Research & Therapy 2018 9:195
    Content type: Research Published on:

  3. Refinement of therapeutic-scale platelet production in vitro will provide a new source for transfusion in patients undergoing chemotherapy or radiotherapy. However, procedures for cost-effective and scalable p...

    Authors: Leisheng Zhang, Cuicui Liu, Hongtao Wang, Dan Wu, Pei Su, Mengge Wang, Jiaojiao Guo, Shixuan Zhao, Shuxu Dong, Wen Zhou, Cameron Arakaki, Xiaobing Zhang and Jiaxi Zhou
    Citation: Stem Cell Research & Therapy 2018 9:194
    Content type: Research Published on:

  4. Compromised wound healing has become a global public health challenge which presents a significant psychological, financial, and emotional burden on patients and physicians. We recently reported that acellular...

    Authors: Nazihah Bakhtyar, Marc G. Jeschke, Elaine Herer, Mohammadali Sheikholeslam and Saeid Amini-Nik
    Citation: Stem Cell Research & Therapy 2018 9:193
    Content type: Research Published on:

  5. Intrauterine adhesions (IUA) are the most common cause of uterine infertility and are caused by endometrium fibrotic regeneration following severe damage to the endometrium. Although current stem cell treatmen...

    Authors: Yun Cao, Haixiang Sun, Hui Zhu, Xianghong Zhu, Xiaoqiu Tang, Guijun Yan, Jingmei Wang, Donghui Bai, Juan Wang, Liu Wang, Qi Zhou, Huiyan Wang, Chengyan Dai, Lijun Ding, Biyun Xu, Yan Zhou…
    Citation: Stem Cell Research & Therapy 2018 9:192
    Content type: Research Published on:

  6. The concept of establishing a dental stem cell (DSC) bank for oral and maxillofacial regeneration has become of great interest but it remains at a primitive stage. The routine application of serum-containing c...

    Authors: Jingyi Xiao, Dawei Yang, Qiwen Li, Weidong Tian and Weihua Guo
    Citation: Stem Cell Research & Therapy 2018 9:191
    Content type: Research Published on:

  7. The fully developed adult skeleton adapts to mechanical forces by generating more bone, usually at the periosteal surface. Progenitor cells in the periosteum are believed to differentiate into bone-forming ost...

    Authors: Emily R. Moore, Ya Xing Zhu, Han Seul Ryu and Christopher R. Jacobs
    Citation: Stem Cell Research & Therapy 2018 9:190
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:229

  8. Desirable cells for human cell therapy would be ones that can be generated by simple isolation and culture techniques using a donor sample obtained by non-invasive methods. To date, the different donor-specifi...

    Authors: Nimshitha Pavathuparambil Abdul Manaph, Mohammed Al-Hawwas, Larisa Bobrovskaya, Patrick T. Coates and Xin-Fu Zhou
    Citation: Stem Cell Research & Therapy 2018 9:189
    Content type: Review Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:222

  9. Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most diabetes-related amputations. DFUs require over US$9 billion for yearly treatment and are now a global public health issue. DFU oc...

    Authors: Lara Lopes, Ocean Setia, Afsha Aurshina, Shirley Liu, Haidi Hu, Toshihiko Isaji, Haiyang Liu, Tun Wang, Shun Ono, Xiangjiang Guo, Bogdan Yatsula, Jianming Guo, Yongquan Gu, Tulio Navarro and Alan Dardik
    Citation: Stem Cell Research & Therapy 2018 9:188
    Content type: Research Published on:

  10. Exosomes are nano-sized vesicles (30–200 nm) constantly released by almost all cells. The ability of exosomes to travel between cells and deliver their cargo, which includes lipids, proteins, and nucleic acids...

    Authors: Byong Seung Cho, Jin Ock Kim, Dae Hyun Ha and Yong Weon Yi
    Citation: Stem Cell Research & Therapy 2018 9:187
    Content type: Letter Published on:

  11. Organoids from human pluripotent stem cells are becoming suitable models for studies of organ development, drug screening, regenerative medicine, and disease modeling. Three-dimensional minilungs in Matrigel c...

    Authors: Esmeralda Magro-Lopez, Charlotte Palmer, Joana Manso, Isabel Liste and Alberto Zambrano
    Citation: Stem Cell Research & Therapy 2018 9:186
    Content type: Short report Published on:

  12. The mammalian target of rapamycin (mTOR) pathway plays a significant role in osteogenic differentiation and bone maintenance. As the only known endogenous inhibitor of mTOR function, DEP domain containing mTOR...

    Authors: Si Chen, Lingfei Jia, Shan Zhang, Yunfei Zheng and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2018 9:185
    Content type: Research Published on:

  13. Mesenchymal stromal cells (MSCs) are promising cell therapy candidates. Clinical application is considered safe. However, minor side effects have included thromboembolism and instant blood-mediated inflammator...

    Authors: P. Netsch, S. Elvers-Hornung, S. Uhlig, H. Klüter, V. Huck, F. Kirschhöfer, G. Brenner-Weiß, K. Janetzko, H. Solz, P. Wuchter, P. Bugert and K. Bieback
    Citation: Stem Cell Research & Therapy 2018 9:184
    Content type: Research Published on:

  14. Diabetes is a proinflammatory state. Fibrosis of the renal glomerulus is the most common cause of end-stage renal disease. Glomerulosclerosis is caused by the accumulation of extracellular matrix (ECM) protein...

    Authors: Ching-Chuan Hsieh, Chun-Liang Lin, Jie-Teng He, Meihua Chiang, Yuhsiu Wang, Yu-Chin Tsai, Chien-Hui Hung and Pey-Jium Chang
    Citation: Stem Cell Research & Therapy 2018 9:183
    Content type: Research Published on:

  15. Osteopontin (OPN), an acidic phosphoglycoprotein, is upregulated in the brain after cerebral ischemia. We previously reported that OPN supports migration, survival, and proliferation of neural stem cells (NSC)...

    Authors: Rebecca Rogall, Monika Rabenstein, Sabine Vay, Annika Bach, Anton Pikhovych, Johannes Baermann, Mathias Hoehn, Sébastien Couillard-Despres, Gereon Rudolf Fink, Michael Schroeter and Maria Adele Rueger
    Citation: Stem Cell Research & Therapy 2018 9:182
    Content type: Research Published on:

  16. Skin injuries in horses frequently lead to chronic wounds that lack a keratinocyte cover essential for healing. The limited proliferation of equine keratinocytes using current protocols has limited their use f...

    Authors: Faris Alkhilaiwi, Liqing Wang, Dan Zhou, Terje Raudsepp, Sharmila Ghosh, Siddartha Paul, Nancy Palechor-Ceron, Sabine Brandt, Jennifer Luff, Xuefeng Liu, Richard Schlegel and Hang Yuan
    Citation: Stem Cell Research & Therapy 2018 9:181
    Content type: Research Published on:

  17. Exosomes are nanovesicles (30–120 nm) of endosomal origin. These exosomes contain various functional proteins and RNAs that could be used for therapeutic purposes. Currently, having a standard method for exoso...

    Authors: Suchi Gupta, Sonali Rawat, Vivek Arora, Sarat Kumar Kottarath, Amit Kumar Dinda, Pradeep Kumar Vaishnav, Baibaswata Nayak and Sujata Mohanty
    Citation: Stem Cell Research & Therapy 2018 9:180
    Content type: Method Published on:

  18. Damaged or malfunctioning sweat glands (SGs) after a burn injury would cause significant hyperthermia and even death, and there is an unmet need for effective treatment. Genetically reprogrammed stem cells sho...

    Authors: Bin Yao, Wei Song, Zhao Li, Tian Hu, Rui Wang, Yihui Wang, Sha Huang and Xiaobing Fu
    Citation: Stem Cell Research & Therapy 2018 9:179
    Content type: Research Published on:

  19. Recently, the capacity of mesenchymal stem/stromal cells (MSCs) to migrate into damaged tissues has been reported. For MSCs to be a promising tool for tissue engineering and cell and gene therapy, it is essent...

    Authors: Alexandra Calle, Clara Barrajón-Masa, Ernesto Gómez-Fidalgo, Mercedes Martín-Lluch, Paloma Cruz-Vigo, Raúl Sánchez-Sánchez and Miguel Ángel Ramírez
    Citation: Stem Cell Research & Therapy 2018 9:178
    Content type: Research Published on:

  20. In cell-based therapy, the transmission of communicable diseases imposes a substantial threat to recipients. In this study, we investigated whether cell-based screening could detect hepatitis B virus (HBV) in ...

    Authors: Wei Liu, Yuanyuan Xie, Tianyun Gao, Feifei Huang, Liudi Wang, Lijun Ding, Wenqing Wang, Shuo Liu, Jianwu Dai and Bin Wang
    Citation: Stem Cell Research & Therapy 2018 9:177
    Content type: Research Published on:

  21. Vascularization is one of the most important processes in tissue-engineered bone graft (TEBG)-mediated regeneration of large segmental bone defects. We previously showed that prevascularization of TEBGs promot...

    Authors: Pengzhen Cheng, Donglin Li, Yi Gao, Tianqing Cao, Huijie Jiang, Jimeng Wang, Junqin Li, Shuaishuai Zhang, Yue Song, Bin Liu, Chunmei Wang, Liu Yang and Guoxian Pei
    Citation: Stem Cell Research & Therapy 2018 9:176
    Content type: Research Published on:

  22. Mesenchymal stem cells (MSCs) have diverse functions in regulating injury and inflammation through the secretion of extracellular vesicles (EVs).

    Authors: Nesrine Ebrahim, Ola Mostafa, Rania Ebrahim El Dosoky, Inas A. Ahmed, Ahmed S. Saad, Abeer Mostafa, Dina Sabry, Khalid Abdelaziz Ibrahim and Ayman Samir Farid
    Citation: Stem Cell Research & Therapy 2018 9:175
    Content type: Research Published on:

  23. Direct intra-articular injection (DIAI) of mesenchymal stem cells (MSCs) is a promising technique for cartilage repair. However, the repair process was hindered by the absence of scaffold and poor cell–matrix ...

    Authors: Hansong Xia, Chi Liang, Pan Luo, Junjie Huang, Jinshen He, Zili Wang, Xu Cao, Cheng Peng and Song Wu
    Citation: Stem Cell Research & Therapy 2018 9:174
    Content type: Research Published on:

  24. Mesenchymal stem cells (MSCs) are promising tools for the treatment of human lung disease and other pathologies relevant to newborn medicine. Recent studies have established MSC exosomes (EXO), as one of the m...

    Authors: Sushma Chaubey, Sam Thueson, Devasena Ponnalagu, Mohammad Afaque Alam, Ciprian P. Gheorghe, Zubair Aghai, Harpreet Singh and Vineet Bhandari
    Citation: Stem Cell Research & Therapy 2018 9:173
    Content type: Research Published on:

  25. Mesenchymal stromal cells (MSC) are components of connective tissues and, in vitro, cell entities characterized by cell adhesion and immunophenotyping, although specific markers for their identification are la...

    Authors: David Alfaro and Agustín G. Zapata
    Citation: Stem Cell Research & Therapy 2018 9:172
    Content type: Research Published on:

  26. Cell therapy for the treatment of intervertebral disc degeneration (IDD) faces serious barriers since tissue-specific adult cells such as nucleus pulposus cells (NPCs) have limited proliferative ability and po...

    Authors: Xiao-Chuan Li, Mao-Sheng Wang, Wei Liu, Cheng-Fan Zhong, Gui-Bin Deng, Shao-Jian Luo and Chun-Ming Huang
    Citation: Stem Cell Research & Therapy 2018 9:171
    Content type: Research Published on:

  27. It has been demonstrated previously that induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (MSCs) have immunosuppressive effects on activated T cells. However, the effects of iPSC-MSCs on qui...

    Authors: Xing-Liang Fan, Qing-Xiang Zeng, Xin Li, Cheng-Lin Li, Zhi-Bin Xu, Xue-Quan Deng, Jianbo Shi, Dong Chen, Song Guo Zheng and Qing-Ling Fu
    Citation: Stem Cell Research & Therapy 2018 9:170
    Content type: Research Published on:

  28. Intra-synovial tendon injuries display poor healing, which often results in reduced functionality and pain. A lack of effective therapeutic options has led to experimental approaches to augment natural tendon ...

    Authors: Mohammad R. Khan, Jayesh Dudhia, Frederic H. David, Roberta De Godoy, Vedika. Mehra, Gillian Hughes, Stephanie G. Dakin, Andrew J. Carr, Allen E. Goodship and Roger K. W. Smith
    Citation: Stem Cell Research & Therapy 2018 9:169
    Content type: Research Published on:

  29. Adipose-derived stem cells (ASCs) have been introduced as an alternative to bone marrow mesenchymal stem cells (BMSCs) for cell-based therapy. However, different studies comparing ASCs and BMSCs have shown con...

    Authors: Samih Mohamed-Ahmed, Inge Fristad, Stein Atle Lie, Salwa Suliman, Kamal Mustafa, Hallvard Vindenes and Shaza B. Idris
    Citation: Stem Cell Research & Therapy 2018 9:168
    Content type: Research Published on:

  30. Human adipose-derived mesenchymal stem cells (hADSCs) are promising cells that may promote hepatocyte differentiation (Hep-Dif) and improve liver function, but the involvement of Cdc42, a key small RhoGTPase w...

    Authors: Diana Chaker, Charbel Mouawad, Albert Azar, Didier Quilliot, Ibrahim Achkar, Ziad Fajloun and Nehman Makdissy
    Citation: Stem Cell Research & Therapy 2018 9:167
    Content type: Research Published on:

  31. Deer antlers are the only known mammalian organ with vascularized cartilage that can completely regenerate. Antlers are of real significance as a model of mammalian stem cell-based regeneration with particular...

    Authors: Wei Zhang, Wenhui Chu, Qingxiu Liu, Dawn Coates, Yudong Shang and Chunyi Li
    Citation: Stem Cell Research & Therapy 2018 9:166
    Content type: Research Published on:

  32. Human induced pluripotent stem (iPS) cells have revolutionised research and spark hopes for future tissue replacement therapies. To obtain high cell numbers, iPS cells can be expanded indefinitely. However, as...

    Authors: David Brenière-Letuffe, Aya Domke-Shibamiya, Arne Hansen, Thomas Eschenhagen, Boris Fehse, Kristoffer Riecken and Justus Stenzig
    Citation: Stem Cell Research & Therapy 2018 9:165
    Content type: Research Published on:

  33. The activation and expansion of bipotent liver progenitor cells (LPCs) are indispensable for liver regeneration after severe or chronic liver injury. However, the underlying molecular mechanisms regulating LPC...

    Authors: Yuting Gu, Weiting Wei, Yiji Cheng, Bing Wan, Xinyuan Ding, Hui Wang, Yanyun Zhang and Min Jin
    Citation: Stem Cell Research & Therapy 2018 9:164
    Content type: Research Published on:

  34. Generation of induced pluripotent stem cells (iPSCs) from human peripheral blood provides a convenient and low-invasive way to obtain patient-specific iPSCs. The episomal vector is one of the best approaches f...

    Authors: Haihui Gu, Xia Huang, Jing Xu, Lili Song, Shuping Liu, Xiao-bing Zhang, Weiping Yuan and Yanxin Li
    Citation: Stem Cell Research & Therapy 2018 9:163
    Content type: Short report Published on:

  35. Osteoarthritis (OA) is a widespread arthritic disease and a primary cause of disability. Increasing evidence suggests that inflammation has a pivotal part in its pathogenesis. Interleukin-1β (IL-1β) is a prima...

    Authors: Bo Gao, Wenjie Gao, Zizhao Wu, Taifeng Zhou, Xianjian Qiu, Xudong Wang, Chengjie Lian, Yan Peng, Anjing Liang, Jincheng Qiu, Yuanxin Zhu, Caixia Xu, Yibing Li, Peiqiang Su and Dongsheng Huang
    Citation: Stem Cell Research & Therapy 2018 9:162
    Content type: Research Published on:

  36. One of the major obstacles facing stem cell therapy is the limited number of functional stem cells available after transplantation due to the harsh microenvironment surrounding the damaged tissue. The aim of t...

    Authors: Mianhuan Li, Yi Lv, Feng Chen, Xiaoyan Wang, Jiang Zhu, Hao Li and Jia Xiao
    Citation: Stem Cell Research & Therapy 2018 9:161
    Content type: Research Published on:

  37. Arterial calcification is associated with cardiovascular disease as a complication of advanced atherosclerosis and is a significant contributor to cardiovascular morbidity and mortality. Osteoblastic different...

    Authors: Shuangshuang Wang, Siwang Hu, Jian Wang, Yahui Liu, Ruochi Zhao, Maoqing Tong, Hanbin Cui, Nan Wu and Xiaomin Chen
    Citation: Stem Cell Research & Therapy 2018 9:160
    Content type: Research Published on:

  38. Mesenchymal stem cells (MSC) have gained credibility as a therapeutic tool partly due to their potential to secrete factors such as cytokines and chemokines. Recently, exosomes, which mediate intercellular com...

    Authors: Xiaochun Liu, Shiwei Wang, Suhui Wu, Qian Hao, Ying Li, Zhuodan Guo and Wenzhen Wang
    Citation: Stem Cell Research & Therapy 2018 9:159
    Content type: Research Published on:

  39. The physiological approach suggests that an environment associating mesenchymal stromal cells with low O2 concentration would be most favorable for the maintenance of hematopoietic stem/progenitor cells (HSPCs). ...

    Authors: Dewan Zhao, Lingjia Liu, Qiang Chen, Fangfang Wang, Qiuyang Li, Qiang Zeng, Jingcao Huang, Maowen Luo, Wenxian Li, Yuhuan Zheng and Ting Liu
    Citation: Stem Cell Research & Therapy 2018 9:158
    Content type: Research Published on:

  40. Efficacious bone substitute is essential for the treatment of a critical size bone defect. Currently, the bone substitutes commonly used in clinical practice lack osteogenic capacity and the therapeutic effica...

    Authors: Wenxiang Chu, Yaokai Gan, Yifu Zhuang, Xin Wang, Jie Zhao, Tingting Tang and Kerong Dai
    Citation: Stem Cell Research & Therapy 2018 9:157
    Content type: Research Published on:

  41. The use of human pluripotent stem cell-derived retinal cells for cell therapy strategies and disease modelling relies on the ability to obtain healthy and organised retinal tissue in sufficient quantities. Gen...

    Authors: Patrick Ovando-Roche, Emma L. West, Matthew J. Branch, Robert D. Sampson, Milan Fernando, Peter Munro, Anastasios Georgiadis, Matteo Rizzi, Magdalena Kloc, Arifa Naeem, Joana Ribeiro, Alexander J. Smith, Anai Gonzalez-Cordero and Robin R. Ali
    Citation: Stem Cell Research & Therapy 2018 9:156
    Content type: Research Published on:

  42. Bone marrow-derived mesenchymal stromal cell (MSC) therapy is a promising treatment for several degenerative ocular diseases; however, no reproducible method of monitoring these cells into the eye has been est...

    Authors: Carolina Assis P. Vilela, Lucas Eduardo B. Souza, Rubens C. Siqueira, Rodrigo T. Calado, Dimas T. Covas and Jayter S. Paula
    Citation: Stem Cell Research & Therapy 2018 9:155
    Content type: Research Published on:

  43. Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a worldwide leading c...

    Authors: Austin C. Boese, Quan-Son Eric Le, Dylan Pham, Milton H. Hamblin and Jean-Pyo Lee
    Citation: Stem Cell Research & Therapy 2018 9:154
    Content type: Review Published on:

  44. Airway disease is a primary cause of morbidity and early mortality for patients with cystic fibrosis (CF). Cell transplantation therapy has proven successful for treating immune disorders and may have the pote...

    Authors: Nigel Farrow, Patricia Cmielewski, Martin Donnelley, Nathan Rout-Pitt, Yuben Moodley, Ivan Bertoncello and David Parsons
    Citation: Stem Cell Research & Therapy 2018 9:153
    Content type: Research Published on:

  45. Amyotrophic lateral sclerosis (ALS) is a motor neuron (MN) disease characterized by the loss of MNs in the central nervous system. As MNs die, patients progressively lose their ability to control voluntary mov...

    Authors: Michal Izrael, Shalom Guy Slutsky, Tamar Admoni, Louisa Cohen, Avital Granit, Arik Hasson, Joseph Itskovitz-Eldor, Lena Krush Paker, Graciela Kuperstein, Neta Lavon, Shiran Yehezkel Ionescu, Leonardo Javier Solmesky, Rachel Zaguri, Alina Zhuravlev, Ella Volman, Judith Chebath…
    Citation: Stem Cell Research & Therapy 2018 9:152
    Content type: Research Published on:

    The Commentary to this article has been published in Stem Cell Research & Therapy 2018 9:241

  46. Aging is one of the key factors that regulate the function of human bone marrow mesenchymal stem cells (hBM-MSCs) and related changes in microRNA (miRNA) expression. However, data reported on aging-related miR...

    Authors: Jun Dong, Zhenhui Zhang, Hongshen Huang, Pei Mo, Chuanfan Cheng, Jianwei Liu, Weizhao Huang, Chaowei Tian, Chongyu Zhang and Jiao Li
    Citation: Stem Cell Research & Therapy 2018 9:151
    Content type: Research Published on:

  47. Thromboangiitis obliterans (TAO), also known as Buerger’s Disease, is an occlusive vasculitis linked with high morbidity and amputation risk. To date, TAO is deemed incurable due to the lack of a definitive tr...

    Authors: Jorge D. Martin-Rufino, Francisco S. Lozano, Alba M. Redondo, Eva M. Villaron, Raquel Rueda, Rafael Fernandez-Samos and Fermin Sanchez-Guijo
    Citation: Stem Cell Research & Therapy 2018 9:150
    Content type: Short report Published on:

  49. Although typically cultured at an atmospheric oxygen concentration (20–21%), adipose-derived stem cells (ASCs) reside under considerable low oxygen tension (physioxia) in vivo. In the present study, we explore...

    Authors: Chang Chen, Qi Tang, Yan Zhang, Mei Yu, Wei Jing and Weidong Tian
    Citation: Stem Cell Research & Therapy 2018 9:148
    Content type: Research Published on:

  50. Human induced pluripotent stem cells-derived mesenchymal stem cells (iPSC-MSCs) have been shown to be effective in Type 2 helper T cells (Th2)-dominant eosinophilic allergic airway inflammation. However, the r...

    Authors: Shu-Bin Fang, Hong-Yu Zhang, Ai-Yun Jiang, Xing-Liang Fan, Yong-Dong Lin, Cheng-Lin Li, Cong Wang, Xiang-Ci Meng and Qing-Ling Fu
    Citation: Stem Cell Research & Therapy 2018 9:147
    Content type: Research Published on:
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