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  1. Mesenchymal stromal cells (MSCs) have broad potential as a cell therapy including for the treatment of drug-resistant inflammatory conditions with abnormal T cell proliferation such as graft-versus-host diseas...

    Authors: Shu Hui Neo, Zhisheng Her, Rashidah Othman, Ching Ann Tee, Li Ching Ong, Yuehua Wang, Irwin Tan, Jaylen Tan, Yanmeng Yang, Zheng Yang, Qingfeng Chen and Laurie A. Boyer
    Citation: Stem Cell Research & Therapy 2023 14:259
    Content type: Research Published on:

  2. Allo-HSCT is a definite approach for the management of a wide variety of lethal and debilitating malignant and non-malignant disorders. However, its two main complications, acute and chronic graft-versus-host ...

    Authors: Rashin Mohseni, Pouya Mahdavi Sharif, Maryam Behfar, Mohammad Reza Modaresi, Rohola Shirzadi, Mahta Mardani, Leila Jafari, Fahimeh Jafari, Zeynab Nikfetrat and Amir Ali Hamidieh
    Citation: Stem Cell Research & Therapy 2023 14:256
    Content type: Research Published on:

  3. This prospective clinical case series aimed to evaluate the effect of suprachoroidal implantation of mesenchymal stem cells (MSCs) in the form of spheroids as a stem cell therapy for retinitis pigmentosa (RP) ...

    Authors: Berna Özkan, Büşra Yılmaz Tuğan, Cansu Hemşinlioğlu, Gözde Sır Karakuş, Özlem Şahin and Ercüment Ovalı
    Citation: Stem Cell Research & Therapy 2023 14:252
    Content type: Research Published on:

  4. Hematopoietic stem cells (HSCs) with the ability to self-renew and differentiate are responsible for maintaining the supply of all types of blood cells. The complex and delicate microenvironment surrounding HS...

    Authors: Guolin Shi, Pan Zhang, Xi Zhang, Jing Li, Xinmin Zheng, Jinxiao Yan, Nu Zhang and Hui Yang
    Citation: Stem Cell Research & Therapy 2023 14:251
    Content type: Review Published on:

  5. Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are a promising cell-free therapy for acute lung injury (ALI). To date, no studies have investigated their biodistribution in ALI or discerned ...

    Authors: Alvin Tieu, Duncan J. Stewart, Damian Chwastek, Casey Lansdell, Dylan Burger and Manoj M. Lalu
    Citation: Stem Cell Research & Therapy 2023 14:250
    Content type: Research Published on:

  6. Cardiovascular complications significantly augment the overall COVID-19 mortality, largely due to the susceptibility of human cardiomyocytes (CMs) to SARS-CoV-2 virus. SARS-CoV-2 virus encodes 27 genes, whose ...

    Authors: Juli Liu, Shiyong Wu, Yucheng Zhang, Cheng Wang, Sheng Liu, Jun Wan and Lei Yang
    Citation: Stem Cell Research & Therapy 2023 14:249
    Content type: Research Published on:

  7. Disco-interacting protein 2 homolog B is a member of the Dip2 family encoded by the Dip2b gene. Dip2b is widely expressed in neuro-related tissues and is essential in axonal outgrowth during embryogenesis.

    Authors: Mingze Yao, Yuanqing Pan, Tinglin Ren, Caiting Yang, Yu Lei, Xiaoyu Xing, Lei Zhang, Xiaogang Cui, Yaowu Zheng, Li Xing and Changxin Wu
    Citation: Stem Cell Research & Therapy 2023 14:248
    Content type: Research Published on:

  8. Dissecting complex interactions among transcription factors (TFs), microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are central for understanding heart development and function. Although computational appr...

    Authors: Shumin Li, Bin Yan, Binbin Wu, Junhao Su, Jianliang Lu, Tak-Wah Lam, Kenneth R. Boheler, Ellen Ngar-Yun Poon and Ruibang Luo
    Citation: Stem Cell Research & Therapy 2023 14:247
    Content type: Research Published on:

  9. Inflammatory memory or trained immunity is a recently described process in immune and non-immune tissue resident cells, whereby previous exposure to inflammation mediators leads to a faster and stronger respon...

    Authors: Jacopo Morroni, Anna Benedetti, Lorenza Esposito, Marco De Bardi, Giovanna Borsellino, Carles Sanchez Riera, Lorenzo Giordani, Marina Bouche and Biliana Lozanoska-Ochser
    Citation: Stem Cell Research & Therapy 2023 14:246
    Content type: Research Published on:

  10. Despite increasing clinical investigations underscoring the efficacy and safety of adipose-derived mesenchymal stem cells (AD-MSCs) therapy in knee osteoarthritis (KOA), no article has recently reviewed the ce...

    Authors: Zongyuan Huang, Shuai Zhang, Mingde Cao, Zhujian Lin, Ling Kong, Xin Wu, Qianshi Guo, Yuxiang Ouyang and Yancheng Song
    Citation: Stem Cell Research & Therapy 2023 14:245
    Content type: Review Published on:

  11. Synovial fluid mesenchymal stem cells (SF-MSCs) originate in the synovium and contribute to the endogenous repair of damaged intra-articular tissues. Here, we clarified the relationship between their numbers a...

    Authors: Hideto Furuoka, Kentaro Endo and Ichiro Sekiya
    Citation: Stem Cell Research & Therapy 2023 14:244
    Content type: Research Published on:

  12. The capacity of skeletal muscles to regenerate relies on Pax7+ muscle stem cells (MuSC). While in vitro-amplified MuSC are activated and lose part of their regenerative capacity, in vitro-generated human muscle r...

    Authors: Axelle Bouche, Benoit Borner, Chloé Richard, Ysaline Grand, Didier Hannouche and Thomas Laumonier
    Citation: Stem Cell Research & Therapy 2023 14:243
    Content type: Research Published on:

  13. Melanocytes are an essential part of the epidermis, and their regeneration has received much attention because propagation of human adult melanocytes in vitro is too slow for clinical use. Differentiation from...

    Authors: Chie Kobori, Ryo Takagi, Ryo Yokomizo, Sakie Yoshihara, Mai Mori, Hiroto Takahashi, Palaksha Kanive Javaregowda, Tomohiko Akiyama, Minoru S. H. Ko, Kazuo Kishi and Akihiro Umezawa
    Citation: Stem Cell Research & Therapy 2023 14:242
    Content type: Research Published on:

  14. Mutations in the cardiac sodium channel gene SCN5A cause Brugada syndrome (BrS), an arrhythmic disorder that is a leading cause of sudden death and lacks effective treatment. An association between SCN5A and Wnt/...

    Authors: Dongsheng Cai, Xiaochen Wang, Yaxun Sun, Hangping Fan, Jingjun Zhou, Zongkuai Yang, Hangyuan Qiu, Jue Wang, Jun Su, Tingyu Gong, Chenyang Jiang and Ping Liang
    Citation: Stem Cell Research & Therapy 2023 14:241
    Content type: Research Published on:

  15. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) can be used to treat heart diseases; however, the optimal maturity of hiPSC-CMs for effective regenerative medicine remains unclear. We ai...

    Authors: Yuki Tanaka, Shin Kadota, Jian Zhao, Hideki Kobayashi, Satomi Okano, Masaki Izumi, Yusuke Honda, Hajime Ichimura, Naoko Shiba, Takeshi Uemura, Yuko Wada, Shinichiro Chuma, Tsutomu Nakada, Shugo Tohyama, Keiichi Fukuda, Mitsuhiko Yamada…
    Citation: Stem Cell Research & Therapy 2023 14:240
    Content type: Research Published on:

  16. Lipodystrophy-associated metabolic disorders caused by Seipin deficiency lead to not only severe lipodystrophy but also neurological disorders. However, the underlying mechanism of Seipin deficiency-induced ne...

    Authors: Jing Yang, Na Yang, Huifang Zhao, Yan Qiao, Yanqiu Li, Chunfang Wang, Kah-Leong Lim, Chengwu Zhang, Wulin Yang and Li Lu
    Citation: Stem Cell Research & Therapy 2023 14:239
    Content type: Research Published on:

  17. This study aimed to explore a novel subtype classification method based on the stemness characteristics of patients with non-small cell lung cancer (NSCLC).

    Authors: Mingshan Liu, Ruihao Zhou, Wei Zou, Zhuofan Yang, Quanjin Li, Zhiguo Chen, Lei jiang and Jingtao Zhang
    Citation: Stem Cell Research & Therapy 2023 14:238
    Content type: Research Published on:

  18. Refractory epilepsy is also known as drug-resistant epilepsy with limited clinical treatment. Benefitting from its safety and easy availability, olfactory mucosa mesenchymal stem cells (OM-MSCs) are considered...

    Authors: Zheng-Zhao Liu, Yan Huang, Chun-Gu Hong, Xin Wang, Ran Duan, Jian-Yang Liu, Jia-Lin He, Da Duan, Hui Xie and Ming Lu
    Citation: Stem Cell Research & Therapy 2023 14:237
    Content type: Research Published on:

  19. Application of autologous adipose-derived stem cells (ASC) for diabetic chronic wounds has become an emerging treatment option. However, ASCs from diabetic individuals showed impaired cell function and subopti...

    Authors: Chun-Wei Li, Tai-Horng Young, Mu-Hui Wang, Ming-Ying Pei, Tsung-Yu Hsieh, Chia-Lang Hsu and Nai-Chen Cheng
    Citation: Stem Cell Research & Therapy 2023 14:236
    Content type: Research Published on:

  20. Although mesenchymal stem cell (MSC) transplantation provides an alternative strategy for end-stage liver disease (ESLD), further widespread application of MSC therapy is limited owing to low cell engraftment ...

    Authors: Shaoxiong Yu, Saihua Yu, Haiyan Liu, Naishun Liao and Xiaolong Liu
    Citation: Stem Cell Research & Therapy 2023 14:235
    Content type: Review Published on:

  21. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible lung disease characterized by pulmonary fibrosis and lung dysfunction, ultimately leading to respiratory failure. Many preclinica...

    Authors: Qun Liu, Youkun Bi, Shaole Song, Keqi Zhu, Xinlong Qiao, Huiwen Wang and Guangju Ji
    Citation: Stem Cell Research & Therapy 2023 14:234
    Content type: Research Published on:

  22. To explore whether local transplantation of mesenchymal stem cells (MSCs) in temporal muscle can promote collateral angiogenesis and to analyze its main mechanisms of promoting angiogenesis.

    Authors: Xincheng Zhang, Yimin Huang, Yuan Liu, Yanchao Liu, Xuejun He, Xiaopeng Ma, Chao Gan, Xin Zou, Sheng Wang, Kai Shu, Ting Lei and Huaqiu Zhang
    Citation: Stem Cell Research & Therapy 2023 14:233
    Content type: Research Published on:

  23. Enteric neuropathies, which result from abnormalities of the enteric nervous system, are associated with significant morbidity and high health-care costs, but current treatments are unsatisfactory. Cell-based ...

    Authors: Ryo Hotta, Ahmed Rahman, Sukhada Bhave, Rhian Stavely, Weikang Pan, Shriya Srinivasan, Geoffrey de Couto, Luis Rodriguez-Borlado, Richard Myers, Alan J. Burns and Allan M. Goldstein
    Citation: Stem Cell Research & Therapy 2023 14:232
    Content type: Research Published on:

  24. Stem cells play a therapeutic role mainly through immunoregulation. However, the immunomodulatory function of stem cells may be affected by inflammation-related factors in patients’ serum. Therefore, this stud...

    Authors: Yong-Hong Wang, Meng-Lan Wang, Ya-Chao Tao, Dong-Bo Wu, En-Qiang Chen and Hong Tang
    Citation: Stem Cell Research & Therapy 2023 14:231
    Content type: Research Published on:

  25. Inflammation is the host's protective response against harmful external stimulation that helps tissue repair and remodeling. However, excessive inflammation seriously threatens the patient's life. Due to anti-...

    Authors: Guan-qiao Liu, Zi-xian Liu, Ze-xin Lin, Peng Chen, Yu-chi Yan, Qing-rong Lin, Yan-jun Hu, Nan Jiang and Bin Yu
    Citation: Stem Cell Research & Therapy 2023 14:230
    Content type: Review Published on:

  26. Native bone marrow (BM) mesenchymal stem/stromal cells (BM-MSCs) participate in generating and shaping the skeleton and BM throughout the lifespan. Moreover, BM-MSCs regulate hematopoiesis by contributing to t...

    Authors: Loïc Fiévet, Nicolas Espagnolle, Daniela Gerovska, David Bernard, Charlotte Syrykh, Camille Laurent, Pierre Layrolle, Julien De Lima, Arthur Justo, Nicolas Reina, Louis Casteilla, Marcos J. Araúzo-Bravo, Abderrahim Naji, Jean-Christophe Pagès and Frédéric Deschaseaux
    Citation: Stem Cell Research & Therapy 2023 14:229
    Content type: Research Published on:

  27. In the last decade, human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM)-based cell therapy has drawn broad attention as a potential therapy for treating injured hearts. However, mass productio...

    Authors: Hao Yang, Yuan Yang, Fedir N. Kiskin, Mengcheng Shen and Joe Z. Zhang
    Citation: Stem Cell Research & Therapy 2023 14:228
    Content type: Review Published on:

  28. A resident vascular endothelial stem cell (VESC) population expressing CD157 and CD200 has been identified recently in the adult mouse. However, the origin of this population and how it develops has not been c...

    Authors: Fitriana N. Rahmawati, Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Hirotaka Konishi, Weizhen Jia and Nobuyuki Takakura
    Citation: Stem Cell Research & Therapy 2023 14:227
    Content type: Research Published on:

  29. Articular cartilage (AC)’s main function is to resist to a stressful mechanical environment, and chondrocytes are responding to mechanical stress for the development and homeostasis of this tissue. However, cu...

    Authors: Noémie Petitjean, Patrick Canadas, Christian Jorgensen, Pascale Royer, Simon Le Floc’h and Danièle Noël
    Citation: Stem Cell Research & Therapy 2023 14:226
    Content type: Research Published on:

  30. Antlers are the only fully regenerable mammalian appendages whose annual renewal is initiated by antler stem cells (ASCs), defined as a specialized type of mesenchymal stem cells (MSCs) with embryonic stem cel...

    Authors: Qi Liu, Jiannan Li, Jinghui Chang, Yu Guo and Dacheng Wen
    Citation: Stem Cell Research & Therapy 2023 14:225
    Content type: Review Published on:

  32. Induced pluripotent stem cells (iPSC) can be differentiated to cells in all three germ layers, as well as cells in the extraembryonic tissues. Efforts in iPSC differentiation into pancreatic progenitors in vit...

    Authors: Matthew R. Arkenberg, Yoshitomo Ueda, Eri Hashino and Chien-Chi Lin
    Citation: Stem Cell Research & Therapy 2023 14:223
    Content type: Research Published on:

  33. Mesenchymal stem cells (MSCs) are widely used in cell therapy, tissue engineering, and regenerative medicine because of their self-renewal, pluripotency, and immunomodulatory properties. The microenvironment i...

    Authors: Zhilong Huang, Yingying Huang, Xiner Ning, Haodi Li, Qiqi Li and Junjie Wu
    Citation: Stem Cell Research & Therapy 2023 14:222
    Content type: Review Published on:

  34. Chronic limb-threatening ischemia (CLTI) represents the final stage of peripheral arterial disease. Approximately one-third of patients with CLTI are not eligible for conventional surgical treatments. Furtherm...

    Authors: Martha L. Arango-Rodríguez, Ligia C. Mateus, Claudia L. Sossa, Silvia M. Becerra-Bayona, Víctor Alfonso Solarte-David, Miguel Enrique Ochoa Vera, Lady T. Giratá Viviescas, Ana M. Vera Berrio, Sergio Eduardo Serrano, Oliverio Vargas, Andrés Catalá Isla, Alape Benitez and Germán Rangel
    Citation: Stem Cell Research & Therapy 2023 14:221
    Content type: Research Published on:

  35. Xerostomia is a salivary gland dysfunction that negatively impacts the life quality of patients; however, there is no effective treatment for xerostomia. Bioengineered organs, generated using stem cells obtain...

    Authors: Bo kyoung Kang, Zhu Zhu, Jian Wang, Jia Zhou, Shun Yu, Xianyu Zhou, Zhenmin Zhao, Aiguo Xie, Lin Lu and Jun Yang
    Citation: Stem Cell Research & Therapy 2023 14:220
    Content type: Research Published on:

  36. Androgenetic alopecia (AGA) is one of the most common hair loss diseases worldwide. However, current treatments including medicine, surgery, and stem cells are limited for various reasons. Cell-free fat extrac...

    Authors: Yizuo Cai, Zhuoxuan Jia, Yichen Zhang, Bijun Kang, Chingyu Chen, Wei Liu, Wei Li and Wenjie Zhang
    Citation: Stem Cell Research & Therapy 2023 14:219
    Content type: Research Published on:

  37. Following an ischemic injury to the brain, the induction of angiogenesis is critical to neurological recovery. The angiogenic benefits of mesenchymal stem cells (MSCs) have been attributed at least in part to ...

    Authors: Jolene Phelps, David A. Hart, Alim P. Mitha, Neil A. Duncan and Arindom Sen
    Citation: Stem Cell Research & Therapy 2023 14:218
    Content type: Research Published on:

  38. Acute respiratory distress syndrome (ARDS) is a life-threatening inflammatory lung injury with high mortality; no approved medication exists. Efficacy and safety of bone marrow–derived, allogeneic, multipotent...

    Authors: Kazuya Ichikado, Toru Kotani, Yasuhiro Kondoh, Hideaki Imanaka, Takeshi Johkoh, Kiminori Fujimoto, Shin Nunomiya, Tomotaka Kawayama, Masanori Sawada, Eric Jenkins, Sadatomo Tasaka and Satoru Hashimoto
    Citation: Stem Cell Research & Therapy 2023 14:217
    Content type: Research Published on:

  39. Mesenchymal stem/stromal cells (MSCs) have been used in clinical trials for various diseases. These have certain notable functions such as homing to inflammation sites, tissue repair, and immune regulation. In...

    Authors: Yukiya Takayama, Kosuke Kusamori, Yuri Katsurada, Shu Obana, Shoko Itakura and Makiya Nishikawa
    Citation: Stem Cell Research & Therapy 2023 14:216
    Content type: Research Published on:

  40. Redox signaling and energy metabolism are known to be involved in controlling the balance between self-renewal and proliferation/differentiation of stem cells. In this study we investigated metabolic and redox...

    Authors: Francesca Agriesti, Francesca Landini, Mirko Tamma, Consiglia Pacelli, Carmela Mazzoccoli, Giovanni Calice, Vitalba Ruggieri, Giuseppe Capitanio, Giorgio Mori, Claudia Piccoli and Nazzareno Capitanio
    Citation: Stem Cell Research & Therapy 2023 14:215
    Content type: Research Published on:

  41. The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer’s disease (AD); however, how it modulates brain homeostasis is not clear. The apoE protein is a major lipid carrier in the brain...

    Authors: Jing Zhao, Tadafumi C. Ikezu, Wenyan Lu, Jesse R. Macyczko, Yonghe Li, Laura J. Lewis-Tuffin, Yuka A. Martens, Yingxue Ren, Yiyang Zhu, Yan W. Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo and Guojun Bu
    Citation: Stem Cell Research & Therapy 2023 14:214
    Content type: Research Published on:

  42. Senescent adipose-derived stem cells (ASCs) exhibit reduced therapeutic efficacy during wound healing. Transcriptional regulation factors including long noncoding RNAs (lncRNAs) reportedly have essential roles...

    Authors: Hewei Xiong, Sen Ren, Jing Chen, Xiaofan Yang, Yutian Liu, Zhao Xu, Jiahe Guo, Tao Jiang, Meng Yuan, Yang Liu, Guolei Zhang, Wenqing Li, Hans-Günther Machens and Zhenbing Chen
    Citation: Stem Cell Research & Therapy 2023 14:213
    Content type: Research Published on:

  43. Retinitis pigmentosa (RP) is an inherited retinal disease that results in photoreceptor degeneration, leading to severe vision loss or blindness. Due to its genetic heterogeneity, developing a new gene therapy...

    Authors: Eric D. Jong, Sabiha Hacibekiroglu, Lily Guo, Evan Sawula, Biao Li, Chengjin Li, Margaret T. Ho, Molly S. Shoichet, Valerie A. Wallace and Andras Nagy
    Citation: Stem Cell Research & Therapy 2023 14:212
    Content type: Research Published on:

  44. The efficacy of human umbilical cord mesenchymal stem cell (hUC-MSC) transplantation in treating systemic lupus erythematosus (SLE) has been confirmed by small-scale clinical trials. However, these trials focu...

    Authors: Fengbiao Guo, Quanren Pan, Ting Chen, Shuzhen Liao, Shangmei Li, Aifen Li, Shuxian Chen, Jiaxuan Chen, Zengzhi Xiao, Hongyong Su, Lawei Yang, Chen Yang, Hua-feng Liu and Qingjun Pan
    Citation: Stem Cell Research & Therapy 2023 14:211
    Content type: Research Published on:

  45. Treatments for AGA have yet to produce satisfactory outcomes and may cause intolerable side effects. Recent studies have reported that adipose tissue-derived stem cell conditioned media (ADSC-CM) could induce ...

    Authors: Lili Legiawati, Lis Surachmiati Suseno, Irma Bernadette S. Sitohang, Shannaz Nadia Yusharyahya, Jeanne Adiwinata Pawitan, Isabella Kurnia Liem, Trie Kurniawati, Athaya Ardelia and Kanya Paramastri
    Citation: Stem Cell Research & Therapy 2023 14:210
    Content type: Research Published on:

  46. Recent advances in methods to culture pluripotent stem cells to model human development have resulted in entities that increasingly have recapitulated advanced stages of early embryo development. These entitie...

    Authors: Ana S. Iltis, Grace Koster, Emily Reeves and Kirstin R. W. Matthews
    Citation: Stem Cell Research & Therapy 2023 14:209
    Content type: Review Published on:

  48. Stem cell therapy is the most promising treatment option for regenerative medicine. Therapeutic effect of different stem cells has been verified in various disease model. Dedifferentiated fat (DFAT) cells, der...

    Authors: Zhuokai Liang, Yufei He, Haojing Tang, Jian Li, Junrong Cai and Yunjun Liao
    Citation: Stem Cell Research & Therapy 2023 14:207
    Content type: Review Published on:

  49. Immunomodulation by mesenchymal stromal cells (MSCs) can occur through trophic factor mechanisms, however, intravenously infused MSCs are rapidly cleared from the body yet a potent immunotherapeutic response i...

    Authors: Michael V. Schrodt, Riley M. Behan-Bush, Jesse N. Liszewski, Madeleine E. Humpal-Pash, Lauren K. Boland, Sabrina M. Scroggins, Donna A. Santillan and James A. Ankrum
    Citation: Stem Cell Research & Therapy 2023 14:206
    Content type: Research Published on:

  50. Skeletal muscle comprises almost 40% of the human body and is essential for movement, structural support and metabolic homeostasis. Size of multinuclear skeletal muscle is stably maintained under steady condit...

    Authors: Takamitsu Tatsukawa, Kohei Kano, Kei-ichi Nakajima, Takashi Yazawa, Ryoji Eguchi, Maki Kabara, Kiwamu Horiuchi, Taiki Hayasaka, Risa Matsuo, Naoyuki Hasebe, Nobuyoshi Azuma and Jun-ichi Kawabe
    Citation: Stem Cell Research & Therapy 2023 14:205
    Content type: Research Published on:
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ISSN: 1757-6512