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  1. Respiratory tract fistulas (or fistulae) are abnormal communications between the respiratory system and the digestive tract or the adjacent organs. The origin can be congenital or, more frequently, iatrogenic ...

    Authors: Angelo Trivisonno, Dania Nachira, Ivo Boškoski, Venanzio Porziella, Giuliana Di Rocco, Silvia Baldari and Gabriele Toietta
    Citation: Stem Cell Research & Therapy 2020 11:451
    Content type: Review Published on:

  4. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Mengge Wang, Hongtao Wang, Yuqi Wen, Xiaoyuan Chen, Xin Liu, Jie Gao, Pei Su, Yuanfu Xu, Wen Zhou, Lihong Shi and Jiaxi Zhou
    Citation: Stem Cell Research & Therapy 2020 11:446
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:340

  5. Osteonecrosis of femoral head (ONFH) is a seriously degenerative disease with no effective therapies to slow its progression. Several studies have reported short-term efficacy of stem cells on early-stage ONFH...

    Authors: Lianghao Mao, Pan Jiang, Xuan Lei, Chenlie Ni, Yiming Zhang, Bing Zhang, Qiping Zheng and Dapeng Li
    Citation: Stem Cell Research & Therapy 2020 11:445
    Content type: Review Published on:

  6. Dysfunction of the DNA methylation was associated with stem cell reprogramming. Moreover, DNA methyltransferase 1 (DNMT1) deficiency was involved in the differentiation of hair follicle stem cell (HFSc), but t...

    Authors: Fangcao Jin, Min Li, Xuyang Li, Yunpeng Zheng, Kun Zhang, Xiaojun Liu, Bingjie Cai and Guangwen Yin
    Citation: Stem Cell Research & Therapy 2020 11:444
    Content type: Research Published on:

  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Daphne Hingert, Karin Ekström, Jonathan Aldridge, Rossella Crescitelli and Helena Brisby
    Citation: Stem Cell Research & Therapy 2020 11:443
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:323

  8. Bone marrow mesenchymal stem cells (BMSCs) have been used as important cell-based tools for clinical applications. Oxidative stress-induced apoptosis causes a low survival rate after transplantation, and the u...

    Authors: Chongxi Fan, Jianyu Feng, Chi Tang, Zhengbin Zhang, Yingtong Feng, Weixun Duan, Mingming Zhai, Zedong Yan, Liwen Zhu, Lele Feng, Hanzhao Zhu and Erping Luo
    Citation: Stem Cell Research & Therapy 2020 11:442
    Content type: Research Published on:

  9. Diabetes is associated with the dysfunction of endothelial progenitor cells (EPCs), characterized as impaired angiogenesis, a phenomenon thought to be involved in the development of diabetic foot. lncRNA plays...

    Authors: Yang Li, Kangkang Zhi, Shilong Han, Xue Li, Maoquan Li, Weishuai Lian, Haijun Zhang and Xiaoping Zhang
    Citation: Stem Cell Research & Therapy 2020 11:441
    Content type: Research Published on:

  10. Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) from the human umbilical cord have been studied extensively due to their immunomodulatory functions. Large-conductance Ca2+-activated K+ (BKCa channels) ch...

    Authors: Ahui Song, Jingjing Wang, Yan Tong, Junyan Fang, Yi Zhang, Huiping Zhang, Hongqiang Ruan, Kai Wang and Yingli Liu
    Citation: Stem Cell Research & Therapy 2020 11:440
    Content type: Research Published on:

  12. Lineage tracing is the most widely used technique to track the migration, proliferation, and differentiation of specific cells in vivo. The currently available gene-targeting technologies have been developing ...

    Authors: Yue Zhang, Fanhong Zeng, Xu Han, Jun Weng and Yi Gao
    Citation: Stem Cell Research & Therapy 2020 11:438
    Content type: Review Published on:

  13. The COVID-19 pandemic has negatively impacted the global public health and the international economy; therefore, there is an urgent need for an effective therapy to treat COVID-19 patients. Mesenchymal stem ce...

    Authors: Sara Al-Khawaga and Essam M. Abdelalim
    Citation: Stem Cell Research & Therapy 2020 11:437
    Content type: Review Published on:

  14. Mesenchymal stem cells are a promising cell source for chondrogenic differentiation and have been widely used in several preclinical and clinical studies. However, they are prone to an unwanted differentiation...

    Authors: Shahrbanoo Jahangir, David Eglin, Naomi Pötter, Mojtaba Khozaei Ravari, Martin J. Stoddart, Ali Samadikuchaksaraei, Mauro Alini, Mohammadreza Baghaban Eslaminejad and Majid Safa
    Citation: Stem Cell Research & Therapy 2020 11:436
    Content type: Research Published on:

  15. The transplantation of bone marrow mesenchymal stem cells (BMSCs) is a promising therapeutic strategy for wound healing. However, the poor migration capacity and low survival rate of transplanted BMSCs in woun...

    Authors: Ling Guo, Juan Du, Dan-feng Yuan, Ya Zhang, Shu Zhang, Hua-cai Zhang, Jun-wei Mi, Ya-lei Ning, Min-jia Chen, Da-lin Wen, Jian-hui Sun, Di Liu, Ling Zeng, Anqiang Zhang, Jianxin Jiang and Hong Huang
    Citation: Stem Cell Research & Therapy 2020 11:434
    Content type: Research Published on:

  17. Current strategies for craniofacial defect are faced with unmet outcome. Combining 3D-printing with safe, noninvasive magnetic therapy could be a promising breakthrough.

    Authors: Chang Tu, Jingyuan Chen, Chunwei Huang, Yifan Xiao, Xiangyu Tang, Hao Li, Yongzhuang Ma, Jiyuan Yan, Weigang Li, Hua Wu and Chaoxu Liu
    Citation: Stem Cell Research & Therapy 2020 11:433
    Content type: Research Published on:

  18. The autologous nerve graft, despite its donor site morbidity and unpredictable functional recovery, continues to be the gold standard in peripheral nerve repair. Rodent research studies have shown promising re...

    Authors: Silvia Palombella, Martino Guiotto, Gillian C. Higgins, Laurent L. Applegate, Wassim Raffoul, Mario Cherubino, Andrew Hart, Mathis O. Riehle and Pietro G. di Summa
    Citation: Stem Cell Research & Therapy 2020 11:432
    Content type: Research Published on:

  19. Considerable progress has been made in converting human pluripotent stem cells (hPSCs) into cortical neurons for disease modeling and regenerative medicine. However, these procedures are hard to provide suffic...

    Authors: Shumei Zhao, Kui Duan, Zongyong Ai, Baohua Niu, Yanying Chen, Ruize Kong and Tianqing Li
    Citation: Stem Cell Research & Therapy 2020 11:431
    Content type: Research Published on:

  20. Bronchioalveolar stem cells (BASCs) located at the bronchioalveolar-duct junction (BADJ) are stem cells residing in alveoli and terminal bronchioles that can self-renew and differentiate into alveolar type (AT...

    Authors: Naoya Kawakita, Hiroaki Toba, Keiko Miyoshi, Shinichi Sakamoto, Daisuke Matsumoto, Mika Takashima, Mariko Aoyama, Seiya Inoue, Masami Morimoto, Takeshi Nishino, Hiromitsu Takizawa and Akira Tangoku
    Citation: Stem Cell Research & Therapy 2020 11:430
    Content type: Research Published on:

  21. Cancer stem cells (CSCs) are considered to be responsible for tumor initiation, formation, and poor prognosis of cancer patients. However, the rarity of CSCs in clinical samples makes it difficult to elucidate...

    Authors: Shuichi Fujiwara, Teruya Kawamoto, Yohei Kawakami, Yasufumi Koterazawa, Hitomi Hara, Toshiyuki Takemori, Kazumichi Kitayama, Shunsuke Yahiro, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Michiyo Koyanagi-Aoi, Takashi Aoi, Ryosuke Kuroda and Toshihiro Akisue
    Citation: Stem Cell Research & Therapy 2020 11:429
    Content type: Research Published on:

  22. Stem cell transplantation has been proposed as an alternative treatment for intractable optic nerve disorders characterized by irrecoverable loss of cells. Mesenchymal stem cells, with varying tissue regenerat...

    Authors: Kyungmin Koh, Mira Park, Eun Soo Bae, Van-An Duong, Jong-Moon Park, Hookeun Lee and Helen Lew
    Citation: Stem Cell Research & Therapy 2020 11:428
    Content type: Research Published on:

  23. Periodontal tissue regeneration (PTR) is the ultimate goal of periodontal therapy. Currently, stem cell therapy is considered a promising strategy for achieving PTR. However, there is still no conclusive compa...

    Authors: Qiang Li, Guangwen Yang, Jialing Li, Meng Ding, Na Zhou, Heng Dong and Yongbin Mou
    Citation: Stem Cell Research & Therapy 2020 11:427
    Content type: Research Published on:

  24. Mesenchymal stem/stromal cells (MSC) have immunomodulatory properties, studied in a wide range of diseases. Validated quality controls must confirm this activity in the context of clinical trials. This study p...

    Authors: Tess Nicotra, Aurélie Desnos, Justine Halimi, Hélène Antonot, Loïc Reppel, Thomas Belmas, Alice Freton, Floriane Stranieri, Miryam Mebarki, Jérôme Larghero, Audrey Cras and Lionel Faivre
    Citation: Stem Cell Research & Therapy 2020 11:426
    Content type: Research Published on:

  25. As a critical cellular component in the hepatic stem cell niche, hepatic stellate cells (HSCs) play critical roles in regulating the expansion of hepatic stem cells, liver regeneration, and fibrogenesis. Howev...

    Authors: Jian-Yun Ge, Yun-Wen Zheng, Tomonori Tsuchida, Kinji Furuya, Hiroko Isoda, Hideki Taniguchi, Nobuhiro Ohkohchi and Tatsuya Oda
    Citation: Stem Cell Research & Therapy 2020 11:425
    Content type: Research Published on:

  26. Mesenchymal stem cells (MSCs) are adult stromal cells that reside in virtually all postnatal tissues. Due to their regenerative and immunomodulatory capacities, MSCs have attracted growing attention during the...

    Authors: Jiangmei Wang, Jie Xia, Ruoqiong Huang, Yaoqin Hu, Jiajie Fan, Qiang Shu and Jianguo Xu
    Citation: Stem Cell Research & Therapy 2020 11:424
    Content type: Review Published on:

  27. Currently, numerous animal studies have shown that exposure to commonly used general anesthetics during pregnancy may cause neurocognitive impairment in the offspring. Reportedly, exposure to sevoflurane durin...

    Authors: Yi Zhang, Ziyi Wu, Xingyue Li, Yuxiao Wan, Yinong Zhang and Ping Zhao
    Citation: Stem Cell Research & Therapy 2020 11:423
    Content type: Research Published on:

  28. Renal tubulointerstitial fibrosis (TIF) plays an important role in the progression of chronic kidney disease (CKD) and its pathogenesis involves epithelial-to-mesenchymal transition (EMT) upon renal injury. Re...

    Authors: Mirae Lee, Seok-hyung Kim, Jong Hyun Jhee, Tae Yeon Kim, Hoon Young Choi, Hyung Jong Kim and Hyeong Cheon Park
    Citation: Stem Cell Research & Therapy 2020 11:422
    Content type: Research Published on:

  29. Extracellular vesicles (EVs) are secretory lipid membranes with the ability to regulate cellular functions by exchanging biological components between different cells. Resident skin cells such as keratinocytes...

    Authors: Golara Nasiri, Negar Azarpira, Aliakbar Alizadeh, Sanaz Goshtasbi and Lobat Tayebi
    Citation: Stem Cell Research & Therapy 2020 11:421
    Content type: Review Published on:

  30. Patients with severe acute pancreatitis (SAP), which is characterized by high morbidity and mortality, account for an increasing medical burden worldwide. We previously found that mesenchymal stem cells (MSCs)...

    Authors: Guodong Song, Jia Zhou, Ruimei Song, Dalu Liu, Weidi Yu, Wangcheng Xie, Zhilong Ma, Jian Gong, Hongbo Meng, Tingsong Yang and Zhenshun Song
    Citation: Stem Cell Research & Therapy 2020 11:420
    Content type: Research Published on:

  31. Stem cell therapy is becoming an emerging therapeutic option for chronic liver disease (CLD). However, whether stem cell therapy is more effective than conventional treatment remains questionable. We performed...

    Authors: Guang-Peng Zhou, Yi-Zhou Jiang, Li-Ying Sun and Zhi-Jun Zhu
    Citation: Stem Cell Research & Therapy 2020 11:419
    Content type: Research Published on:

  32. Immune system disorders play important roles in acute lung injury (ALI), and mesenchymal stem cell (MSC) treatment can reduce inflammation during ALI. In this study, we compared the changes in lung B cells dur...

    Authors: Bing Feng, Jiaqi Zhu, Yanping Xu, Wenyi Chen, Xinyu Sheng, Xudong Feng, Xiaowei Shi, Jingqi Liu, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Lanjuan Li and Hongcui Cao
    Citation: Stem Cell Research & Therapy 2020 11:418
    Content type: Research Published on:

  33. Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) show tremendous promise for cardiac regeneration, but the successful development of hESC-CM-based therapies requires improved tools to investigate th...

    Authors: Dominic Filice, Wahiba Dhahri, Joell L. Solan, Paul D. Lampe, Erin Steele, Nikita Milani, Benjamin Van Biber, Wei-Zhong Zhu, Tamilla Sadikov Valdman, Rocco Romagnuolo, José David Otero-Cruz, Kip D. Hauch, Matthew W. Kay, Narine Sarvazyan and Michael A. Laflamme
    Citation: Stem Cell Research & Therapy 2020 11:417
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:66

  34. Mesenchymal stem cells (MSCs) have been recognized for their regenerative and anti-inflammatory capacity which makes them very attractive to cell therapy, especially those ones to treat inflammatory and autoim...

    Authors: Mónica Kurte, Ana María Vega-Letter, Patricia Luz-Crawford, Farida Djouad, Danièle Noël, Maroun Khoury and Flavio Carrión
    Citation: Stem Cell Research & Therapy 2020 11:416
    Content type: Research Published on:

  35. Millions suffer from skin diseases. Functional interfollicular epidermal stem cells are needed in skin therapy or drug screening in vitro. We obtained functional interfollicular epidermal stem cells with intac...

    Authors: Ling Leng, Jie Ma, Luye Lv, Wenjuan Wang, Dunqin Gao, Yunping Zhu and Zhihong Wu
    Citation: Stem Cell Research & Therapy 2020 11:415
    Content type: Short report Published on:

  36. The therapeutic role of mesenchymal stem cells (MSCs) has been widely confirmed in several animal models of premature infant diseases. Micromolecule peptides have shown promise for the treatment of premature i...

    Authors: Yu Wang, Lin Zhang, Yun Wu, Rongping Zhu, Yan Wang, Yan Cao, Wei Long, Chenbo Ji, Huaiyan Wang and Lianghui You
    Citation: Stem Cell Research & Therapy 2020 11:414
    Content type: Research Published on:

  37. Ischaemic stroke has become the main cause of death and severe neurological disorders, for which effective restorative treatments are currently limited. While stem cell transplantation offers therapeutic poten...

    Authors: Xuemei Zhang, Hao Tang, Senlin Mao, Bing Li, Yinglian Zhou, Hui Yue, Duo Wang, Yifei Wang and Jin Fu
    Citation: Stem Cell Research & Therapy 2020 11:413
    Content type: Research Published on:

  38. Cell therapy is one of the most promising therapeutic interventions for retinitis pigmentosa. In the current study, we aimed to assess if peripheral blood-derived monocytes which are highly abundant and access...

    Authors: Alaknanda Mishra, K. Varsha Mohan, Perumal Nagarajan, Srikanth Iyer, Ashwani Kesarwani, Madhu Nath, Laxmi Moksha, Jashdeep Bhattacharjee, Barun Das, Kshama Jain, Parul Sahu, Prakriti Sinha, T. Velapandian and Pramod Upadhyay
    Citation: Stem Cell Research & Therapy 2020 11:412
    Content type: Research Published on:

  39. Retinal pigment epithelium (RPE) replacement has been proposed as an efficacious treatment for age-related macular degeneration (AMD), which is the primary cause of vision loss in the elderly worldwide. The em...

    Authors: Jiahui Liu, Liu Yang, Xiaoran Wang, Shoubi Wang, Zheqian Huang, Chaoyang Li, Ying Liu, Yaqi Cheng, Chengxiu Liu and Zhichong Wang
    Citation: Stem Cell Research & Therapy 2020 11:411
    Content type: Research Published on:

  40. Acute kidney injury (AKI) is a common clinical disease with complex pathophysiology and limited therapeutic choices. This prompts the need for novel therapy targeting multiple aspects of this disease. Human am...

    Authors: Yifei Ren, Ying Chen, Xizi Zheng, Hui Wang, Xin Kang, Jiawei Tang, Lei Qu, Xiaoyan Shao, Suxia Wang, Shuangling Li, Gang Liu and Li Yang
    Citation: Stem Cell Research & Therapy 2020 11:410
    Content type: Research Published on:

  41. Endothelial cells (ECs) are essential regulators of the vasculature, lining arteries, veins, and capillary beds. While all ECs share a number of structural and molecular features, heterogeneity exists dependin...

    Authors: Kelly Mulfaul, Joseph C. Giacalone, Andrew P. Voigt, Megan J. Riker, Dalyz Ochoa, Ian C. Han, Edwin M. Stone, Robert F. Mullins and Budd A. Tucker
    Citation: Stem Cell Research & Therapy 2020 11:409
    Content type: Method Published on:

  42. This study is designed to generate and propagate human spermatogonial stem cells (SSCs) derived from human pluripotent stem cells (hPSCs).

    Authors: Huiming Xu, Mengbo Yang, Ruhui Tian, Yonghui Wang, Linhong Liu, Zijue Zhu, Shi Yang, Qingqing Yuan, Minghui Niu, Chencheng Yao, Erlei Zhi, Peng Li, Chenhao Zhou, Zuping He, Zheng Li and Wei-Qiang Gao
    Citation: Stem Cell Research & Therapy 2020 11:408
    Content type: Research Published on:

  43. Human platelet lysate (HPL) is emerging as the preferred xeno-free supplement for the expansion of mesenchymal stromal cells (MSCs) for bone tissue engineering (BTE) applications. Due to a growing demand, the ...

    Authors: Siddharth Shanbhag, Samih Mohamed-Ahmed, Turid Helen Felli Lunde, Salwa Suliman, Anne Isine Bolstad, Tor Hervig and Kamal Mustafa
    Citation: Stem Cell Research & Therapy 2020 11:351
    Content type: Research Published on:

  44. In recent years, significant progress has been made in developing highly complex tissue-engineered skin substitutes (TESSs) for wound healing. However, the lack of skin appendages, such as hair follicles and s...

    Authors: Qun Zhang, Jie Wen, Chang Liu, Chuan Ma, Fuxiang Bai, Xue Leng, Zhihong Chen, Zhiwei Xie, Jun Mi and Xunwei Wu
    Citation: Stem Cell Research & Therapy 2020 11:407
    Content type: Research Published on:

  45. A major challenge for the clinical use of human pluripotent stem cells is the development of safe, robust and controlled differentiation protocols. Adaptation of research protocols using reagents designated as...

    Authors: Loriana Vitillo, Catherine Durance, Zoe Hewitt, Harry Moore, Austin Smith and Ludovic Vallier
    Citation: Stem Cell Research & Therapy 2020 11:406
    Content type: Research Published on:

  46. The aim of this study was to examine the effect of a three-step approach that utilizes the application of adipose tissue-derived mesenchymal stem cells (AD-MSCs), encapsulation, and pulsed focused ultrasound (...

    Authors: Mehdi Razavi, Tanchen Ren, Fengyang Zheng, Arsenii Telichko, Jing Wang, Jeremy J. Dahl, Utkan Demirci and Avnesh S. Thakor
    Citation: Stem Cell Research & Therapy 2020 11:405
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:526

  49. Tendon stem cells (TSCs) have been reported to hold promises for tendon repair and regeneration. However, less is known about the effects of exosomes derived from TSCs. Therefore, we aimed to clarify the heali...

    Authors: Mingzhao Zhang, Hengchen Liu, Qingbo Cui, Peilin Han, Shulong Yang, Manyu Shi, Tingting Zhang, Zenan Zhang and Zhaozhu Li
    Citation: Stem Cell Research & Therapy 2020 11:402
    Content type: Research Published on:

  50. Globally, 1 in 11 adults have diabetes mellitus, and 90% of the cases are type 2 diabetes mellitus. Insulin resistance is a central defect in type 2 diabetes mellitus, and although multiple drugs have been dev...

    Authors: Guang Chen, Xiao-yan Fan, Xiao-peng Zheng, Yue-lei Jin, Ying Liu and Shuang-chun Liu
    Citation: Stem Cell Research & Therapy 2020 11:401
    Content type: Research Published on:
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