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  1. White smoke inhalation (WSI) is an uncommon but potentially deadly cause of acute lung injury and acute respiratory distress syndrome for which no effective pharmaceutical treatment has been developed. This st...

    Authors: Pei Cui, Haiming Xin, Yongming Yao, Shichu Xiao, Feng Zhu, Zhenyu Gong, Zhiping Tang, Qiu Zhan, Wei Qin, Yanhua Lai, Xiaohui Li, Yalin Tong and Zhaofan Xia
    Citation: Stem Cell Research & Therapy 2018 9:101
  2. With the development of osteoimmunology and bone tissue engineering (BTE), it has been recognized that the immunomodulatory properties of bone biomaterials have considerable impact in determining their fate af...

    Authors: Tao Li, Zhong Long Liu, Ming Xiao, Ze Zheng Yang, Ming Zheng Peng, Cui Di Li, Xiao Jun Zhou and Jin Wu Wang
    Citation: Stem Cell Research & Therapy 2018 9:100
  3. Bullosis diabeticorum is a rare presentation of cutaneous manifestation most commonly affecting the lower limbs in patients with diabetes. The appearance, often as insidious as its resolution, is characterized...

    Authors: Yan Chen, Yu Ma, Ning Li, Hongyan Wang, Bing Chen, Ziwen Liang, Rui Ren, Debin Lu, Johnson Boey, David G. Armstrong and Wuquan Deng
    Citation: Stem Cell Research & Therapy 2018 9:99
  4. Nicotine has negative effects on tissue repair, little research concerns its effect on the cartilage repair of tissue engineering stem cells. The present study aimed to investigate the effects of nicotine on t...

    Authors: Kai Tie, Min Wu, Yu Deng, Yinxian Wen, Dan Xu, Liaobin Chen and Hui Wang
    Citation: Stem Cell Research & Therapy 2018 9:98
  5. Commitment of pluripotent stem cells into differentiated cells and associated gene expression necessitate specific epigenetic mechanisms that modify the DNA and corresponding histone proteins to render the chr...

    Authors: Varsha Pursani, Deepa Bhartiya, Vivek Tanavde, Mohsin Bashir and Prabha Sampath
    Citation: Stem Cell Research & Therapy 2018 9:97
  6. It is currently unknown if the intrathecal administration of a high dose of allogeneic mesenchymal stem cells (MSCs) is safe, how MSCs migrate throughout the vertebral canal after intrathecal administration, a...

    Authors: Danielle Jaqueta Barberini, Monica Aleman, Fabio Aristizabal, Mathieu Spriet, Kaitlin C. Clark, Naomi J. Walker, Larry D. Galuppo, Rogério Martins Amorim, Kevin D. Woolard and Dori L. Borjesson
    Citation: Stem Cell Research & Therapy 2018 9:96
  7. Mesenchymal stem cells have potential applications in inflammatory bowel disease due to their immunomodulatory properties. Our aim was to evaluate the feasibility, safety and efficacy of endoscopic administrat...

    Authors: Eduardo Martín Arranz, María Dolores Martín Arranz, Tomás Robredo, Pablo Mancheño-Corvo, Ramón Menta, Francisco Javier Alves, Jose Manuel Suárez de Parga, Pedro Mora Sanz, Olga de la Rosa, Dirk Büscher, Eleuterio Lombardo and Fernando de Miguel
    Citation: Stem Cell Research & Therapy 2018 9:95
  8. Upon orthognathic mandibular advancement surgery the adjacent soft tissues can displace the distal bone segment and increase the load on the temporomandibular joint causing loss of its integrity. Remodeling of...

    Authors: Ricardo de Souza Tesch, Esther Rieko Takamori, Karla Menezes, Rosana Bizon Vieira Carias, Cláudio Leonardo Milione Dutra, Marcelo de Freitas Aguiar, Tânia Salgado de Sousa Torraca, Alexandra Cristina Senegaglia, Cármen Lúcia Kuniyoshi Rebelatto, Debora Regina Daga, Paulo Roberto Slud Brofman and Radovan Borojevic
    Citation: Stem Cell Research & Therapy 2018 9:94
  9. Mesenchymal stem cells (MSCs) are multipotent cells holding much promise for applications in regenerative medicine. However, with problems such as aging, increases in heteroploid cells, genomic instability, an...

    Authors: Koichi Fujisawa, Kazusa Hara, Taro Takami, Sae Okada, Toshihiko Matsumoto, Naoki Yamamoto and Isao Sakaida
    Citation: Stem Cell Research & Therapy 2018 9:93
  10. Replacement therapy for hemophilia remains a lifelong treatment. Only gene therapy can cure hemophilia at a fundamental level. The clustered regularly interspaced short palindromic repeats–CRISPR associated nu...

    Authors: Cuicui Lyu, Jun Shen, Rui Wang, Haihui Gu, Jianping Zhang, Feng Xue, Xiaofan Liu, Wei Liu, Rongfeng Fu, Liyan Zhang, Huiyuan Li, Xiaobing Zhang, Tao Cheng, Renchi Yang and Lei Zhang
    Citation: Stem Cell Research & Therapy 2018 9:92
  11. Inflammatory bowel disease (IBD) is an intractable autoimmune disorder that markedly deteriorates one’s quality of life. Mesenchymal stem cells (MSCs) alleviate inflammation by modulating inflammatory cytokine...

    Authors: Woo-Jin Song, Qiang Li, Min-Ok Ryu, Jin-Ok Ahn, Dong Ha Bhang, Yun Chan Jung and Hwa-Young Youn
    Citation: Stem Cell Research & Therapy 2018 9:91
  12. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive muscle weakness, paralysis and death. There is no effective treatment for ALS and stem cell therapy has arisen a...

    Authors: Amaya Rando, Diego Pastor, Mari Carmen Viso-León, Anna Martínez, Raquel Manzano, Xavier Navarro, Rosario Osta and Salvador Martínez
    Citation: Stem Cell Research & Therapy 2018 9:90
  13. The Th1 cell-specific transcription factor TBX21 functions as a regulator of expression of a Th1 cytokine, interferon gamma (IFN-γ). However, the specific function of TBX21 correlated with cancer stemness rema...

    Authors: Shuangtao Zhao, Wenzhi Shen, Jiangyong Yu and Luhua Wang
    Citation: Stem Cell Research & Therapy 2018 9:89
  14. Skeletal muscle plays an important role in the body’s physiology but there are still no effective treatments for volumetric muscle loss (VML) resulting from severe traumatic injury or tumor excision. Recent st...

    Authors: Xinyu Qiu, Shiyu Liu, Hao Zhang, Bin Zhu, Yuting Su, Chenxi Zheng, Rong Tian, Miao Wang, Huijuan Kuang, Xinyi Zhao and Yan Jin
    Citation: Stem Cell Research & Therapy 2018 9:88
  15. Adult mesenchymal stem cells (MSCs) are an important resource for tissue growth, repair, and regeneration. To utilize MSCs more effectively, a clear understanding of how they react to environmental cues is ess...

    Authors: Jihee Sohn, Hang Lin, Madalyn Rose Fritch and Rocky S. Tuan
    Citation: Stem Cell Research & Therapy 2018 9:86
  16. Mesenchymal stem cell (MSC) transplantation shows promise for treating transplant arteriosclerosis, at least partly via promoting endothelial regeneration. However, the efficacy and safety are still under inve...

    Authors: Xiaohu Meng, Min Chen, Wenjie Su, Xuan Tao, Mingyang Sun, Xiaoping Zou, Rongchao Ying, Wei Wei and Baolin Wang
    Citation: Stem Cell Research & Therapy 2018 9:85
  17. Despite the significant progress in the development of skin equivalents (SEs), the problem of noninvasively assessing the quality of the cell components and the collagen structure of living SEs both before and...

    Authors: Aleksandra V. Meleshina, Olga S. Rogovaya, Varvara V. Dudenkova, Marina A. Sirotkina, Maria M. Lukina, Alena S. Bystrova, Victoria G. Krut, Daria S. Kuznetsova, Ekaterina P. Kalabusheva, Andrey V. Vasiliev, Ekaterina A. Vorotelyak and Elena V. Zagaynova
    Citation: Stem Cell Research & Therapy 2018 9:84
  18. The expression of a specific combination of transcription factors (TFs) in the multipotent progenitor cells (MPCs) is critical for determining pancreatic cell fate. NKX6.1 expression in PDX1+ MPCs is required for...

    Authors: Idil I. Aigha, Bushra Memon, Ahmed K. Elsayed and Essam M. Abdelalim
    Citation: Stem Cell Research & Therapy 2018 9:83
  19. Inflammatory licensed mesenchymal stem cells (MSCs) have the ability to promote functional tissue repair. This study specifically sought to understand how the recipient tissue environment reciprocally affects ...

    Authors: Jennifer M. Cassano, Lauren V. Schnabel, Margaret B. Goodale and Lisa A. Fortier
    Citation: Stem Cell Research & Therapy 2018 9:82
  20. Previous studies have reported that transplantation of mesenchymal stem cells (MSCs) from many human tissues could ameliorate ovarian dysfunction. However, no study has revealed the therapeutic efficiency of M...

    Authors: Jun Li, Qingtong Yu, Haisen Huang, Wenwen Deng, Xia Cao, Michael Adu-Frimpong, Jiangnan Yu and Ximing Xu
    Citation: Stem Cell Research & Therapy 2018 9:81
  21. Latent microorganism infection is a safety concern for the clinical application of mesenchymal stem cells (MSCs). The aim of this study is to investigate the frequencies and sensitivities of the latent virus a...

    Authors: Ken Watanabe, Koji Otabe, Norio Shimizu, Keiichirou Komori, Mitsuru Mizuno, Hisako Katano, Hideyuki Koga and Ichiro Sekiya
    Citation: Stem Cell Research & Therapy 2018 9:80
  22. In the bone tissue engineering domain, seed cells, scaffold and cell-scaffold composites are three focuses. In this study, the feasibility of using allogeneic adipose-derived stem cells(ADSCs) combined with he...

    Authors: Jia Liu, Peng Zhou, Yu Long, Chunxia Huang and Danna Chen
    Citation: Stem Cell Research & Therapy 2018 9:79
  23. The marrow microenvironment and vasculature plays a critical role in regulating hematopoietic cell recruitment, residence, and maturation. Extensive in vitro and in vivo studies have aimed to understand the marro...

    Authors: Surya S. Kotha, Brian J. Hayes, Kiet T. Phong, Meredith A. Redd, Karol Bomsztyk, Aravind Ramakrishnan, Beverly Torok-Storb and Ying Zheng
    Citation: Stem Cell Research & Therapy 2018 9:77
  24. The original article [1] contains an error whereby the corresponding authorship is mistakenly designated to the author Fengxia Ding.

    Authors: Bo Liu, Fengxia Ding, Dong Hu, Yu Zhou, Chunlan Long, Lianju Shen, Yuanyuan Zhang, Deying Zhang and Guanghui Wei
    Citation: Stem Cell Research & Therapy 2018 9:76

    The original article was published in Stem Cell Research & Therapy 2018 9:7

  25. Mesenchymal stem cells (MSCs) produced for clinical purposes rely on culture media containing fetal bovine serum (FBS) which is xenogeneic and has the potential to significantly alter the MSC phenotype, render...

    Authors: Maria C. Naskou, Scarlett M. Sumner, Anna Chocallo, Hannah Kemelmakher, Merrilee Thoresen, Ian Copland, Jacques Galipeau and John F. Peroni
    Citation: Stem Cell Research & Therapy 2018 9:75
  26. Three-dimensional (3D) cultures recapitulate the microenvironment of tissue-resident stem cells and enable them to modulate their properties. We determined whether salivary gland-resident stem cells (SGSCs) ar...

    Authors: Hyun-Soo Shin, Songyi Lee, Hye Jin Hong, Young Chang Lim, Won-Gun Koh and Jae-Yol Lim
    Citation: Stem Cell Research & Therapy 2018 9:74
  27. Three-dimensional (3D) cultured clumps of mesenchymal stem cell (MSC)/extracellular matrix (ECM) complexes (C-MSCs) consist of cells and self-produced ECM. C-MSCs can regulate cellular functions in vitro and c...

    Authors: Souta Motoike, Mikihito Kajiya, Nao Komatsu, Manabu Takewaki, Susumu Horikoshi, Shinji Matsuda, Kazuhisa Ouhara, Tomoyuki Iwata, Katsuhiro Takeda, Tsuyoshi Fujita and Hidemi Kurihara
    Citation: Stem Cell Research & Therapy 2018 9:73
  28. Induced pluripotent stem-cell derived endothelial cells (iPSC-ECs) can be generated from any somatic cell and their iPSC sources possess unlimited self-renewal. Previous demonstration of their proangiogenic ac...

    Authors: Richard P. Tan, Alex H. P. Chan, Katarina Lennartsson, Maria M. Miravet, Bob S. L. Lee, Jelena Rnjak-Kovacina, Zoe E. Clayton, John P. Cooke, Martin K. C. Ng, Sanjay Patel and Steven G. Wise
    Citation: Stem Cell Research & Therapy 2018 9:70
  29. While a shift towards non-viral and animal component-free methods of generating induced pluripotent stem (iPS) cells is preferred for safer clinical applications, there is still a shortage of reliable cell sou...

    Authors: Srijaya Thekkeparambil Chandrabose, Sandhya Sriram, Subha Subramanian, Shanshan Cheng, Wee Kiat Ong, Steve Rozen, Noor Hayaty Abu Kasim and Shigeki Sugii
    Citation: Stem Cell Research & Therapy 2018 9:68
  30. Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have been widely used to generate cellular models harboring specific disease-related genotypes. Of particular importance are ESC and iPSC ...

    Authors: Meixiang Zhang, Justine Ngo, Filomena Pirozzi, Ying-Pu Sun and Anthony Wynshaw-Boris
    Citation: Stem Cell Research & Therapy 2018 9:67
  31. Recent studies have suggested that the regulation of endogenous neural stem cells (NSCs) or transplanting of exogenous nerve cells are the newest and most promising methods for the treatment of dementia and ot...

    Authors: Chao Ren, Peiyuan Yin, Neng Ren, Zhe Wang, Jiahui Wang, Caiyi Zhang, Wei Ge, Deqin Geng and Xiaotong Wang
    Citation: Stem Cell Research & Therapy 2018 9:66
  32. Mesenchymal stem cells (MSCs) are a reliable resource for bone regeneration and tissue engineering, but the molecular mechanisms of differentiation remain unclear. The tumor antigen 15-leucine-rich repeat cont...

    Authors: Yuejun Wang, Yunsong Liu, Min Zhang, Longwei Lv, Xiao Zhang, Ping Zhang and Yongsheng Zhou
    Citation: Stem Cell Research & Therapy 2018 9:65
  33. Scarring is the product of natural restoration, yet its treatment remains challenging. Both collagen and fibroblasts are abnormally abundant in scars, leading to scar hyperplasia or contracture. Several clinic...

    Authors: Xiao Xu, Linying Lai, Xuyi Zhang, Jinhong Chen, Junnan Chen, Fei Wang, Jingchen Zheng and Minliang Chen
    Citation: Stem Cell Research & Therapy 2018 9:64
  34. Mesenchymal stem cells (MSCs) are multipotent stem cells that have gained significant attention in the field of regenerative medicine. The differentiation potential along with paracrine properties of MSCs have...

    Authors: Somayeh Keshtkar, Negar Azarpira and Mohammad Hossein Ghahremani
    Citation: Stem Cell Research & Therapy 2018 9:63
  35. Mesenchymal stem cells derived from gingiva (GMSCs) display profound immunomodulation properties in addition to self-renewal and multilineage differentiation capacities. Hydrogen sulfide (H2S) is not only an envi...

    Authors: Ruili Yang, Tingting Yu, Dawei Liu, Songtao Shi and Yanheng Zhou
    Citation: Stem Cell Research & Therapy 2018 9:62
  36. Intervertebral disc (IVD) degeneration is characterized by an early decrease in cellularity of the nucleus pulposus (NP) region, and associated extracellular matrix changes, reduced hydration, and progressive ...

    Authors: Ruhang Tang, Liufang Jing, Vincent P. Willard, Chia-lung Wu, Farshid Guilak, Jun Chen and Lori A. Setton
    Citation: Stem Cell Research & Therapy 2018 9:61
  37. Use of bioscaffolds to direct osteogenic differentiation of adult multipotent stromal cells (MSCs) without exogenous proteins is a contemporary approach to bone regeneration. Identification of in vivo osteogen...

    Authors: Wei Duan, Cong Chen, Masudul Haque, Daniel Hayes and Mandi J. Lopez
    Citation: Stem Cell Research & Therapy 2018 9:60
  38. The advent of human-induced pluripotent stem cells holds great promise for producing ample individualized hepatocytes. Although previous efforts have succeeded in generating hepatocytes from human pluripotent ...

    Authors: Cong Du, Yuan Feng, Dongbo Qiu, Yan Xu, Mao Pang, Nan Cai, Andy Peng Xiang and Qi Zhang
    Citation: Stem Cell Research & Therapy 2018 9:58
  39. The reciprocal fate decision of mesenchymal stem cells (MSCs) to either bone or adipocytes is determined by Wnt-related signaling and the glucagon-like peptide-1 receptor (GLP-1R). Azoramide, an ER stress alle...

    Authors: Banjun Ruan, Zheng Zhu, Zhao Yan, Wei Yang, Dongsheng Zhai, Li Wang, Zichen Ye, Huanyu Lu, An Xiang, Jingwei Liang, Yinghao Jiang, Chengming Xu, Zhenyu Wang, Ming Wei, Xiaoying Lei, Xiaorui Cao…
    Citation: Stem Cell Research & Therapy 2018 9:57
  40. Circular RNAs (circRNAs) are regarded as a novel class of noncoding RNA regulators. Although a number of circRNAs have been identified by bioinformatics analysis of RNA-seq data, tissue and disease-specific ci...

    Authors: Wei Lei, Tingting Feng, Xing Fang, You Yu, Junjie Yang, Zhen-Ao Zhao, Junwei Liu, Zhenya Shen, Wenbo Deng and Shijun Hu
    Citation: Stem Cell Research & Therapy 2018 9:56
  41. Although many reports show that various kinds of stem cells have the ability to recover function in premature ovarian aging, few studies have looked at stem cell treatment of natural ovarian aging (NOA). We de...

    Authors: Chenyue Ding, Qinyan Zou, Fuxin Wang, Huihua Wu, Rulei Chen, Jinghuan Lv, Mingfa Ling, Jian Sun, Wei Wang, Hong Li and Boxian Huang
    Citation: Stem Cell Research & Therapy 2018 9:55
  42. Shockwaves and mesenchymal stem cells (MSCs) have been widely accepted as useful tools for many orthopedic applications. However, the modulatory effects of shockwaves on MSCs remain controversial. In this stud...

    Authors: Hao Zhang, Zhong-Li Li, Fei Yang, Qiang Zhang, Xiang-Zheng Su, Ji Li, Ning Zhang, Chun-Hui Liu, Ning Mao and Heng Zhu
    Citation: Stem Cell Research & Therapy 2018 9:54
  43. Adipose-derived stem cells (ADSCs) are an attractive cell source for bone tissue engineering and have great potential for bone regeneration and defect repair. The transcriptional coactivator with PDZ-binding m...

    Authors: Yumin Zhu, Yaping Wu, Jie Cheng, Qiong Wang, Zhongwu Li, Yanling Wang, Dongmiao Wang, Hua Wang, Weibing Zhang, Jinhai Ye, Hongbing Jiang and Lin Wang
    Citation: Stem Cell Research & Therapy 2018 9:53
  44. Human mesenchymal stem cell (hMSC) differentiation into osteoblasts has important clinical significance in treating bone injury, and the stiffness of the extracellular matrix (ECM) has been shown to be an impo...

    Authors: Meiyu Sun, Guangfan Chi, Juanjuan Xu, Ye Tan, Jiayi Xu, Shuang Lv, Ziran Xu, Yuhan Xia, Lisha Li and Yulin Li
    Citation: Stem Cell Research & Therapy 2018 9:52

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