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  2. Liver stem cell therapy (SCT) has been suggested as a promising means to improve liver regeneration in advanced liver disease. However, data from trials are heterogeneous, with no systematic histological evalu...

    Authors: Nicolas Lanthier, Nathalie Lin-Marq, Laura Rubbia-Brandt, Sophie Clément, Nicolas Goossens and Laurent Spahr
    Citation: Stem Cell Research & Therapy 2017 8:88
    Content type: Research Published on:

  3. The incidence of inflammatory bowel diseases (IBD) is increasing worldwide with patients experiencing severe impacts on their quality of life. It is well accepted that intestinal inflammation associates with e...

    Authors: Ainsley M. Robinson, Ahmed A. Rahman, Sarah Miller, Rhian Stavely, Samy Sakkal and Kulmira Nurgali
    Citation: Stem Cell Research & Therapy 2017 8:87
    Content type: Research Published on:

  4. Pancreatic beta cells are unique effectors in the control of glucose homeostasis and their deficiency results in impaired insulin production leading to severe diabetic diseases. Here, we investigated the poten...

    Authors: Violeta Mitutsova, Wendy Wai Yeng Yeo, Romain Davaze, Celine Franckhauser, El-Habib Hani, Syahril Abdullah, Patrice Mollard, Marie Schaeffer, Anne Fernandez and Ned J. C. Lamb
    Citation: Stem Cell Research & Therapy 2017 8:86
    Content type: Research Published on:

  5. Mesenchymal stem cells (MSCs) show therapeutic efficacy in many different age-related degenerative diseases, including Alzheimer’s disease. Very little is currently known about whether or not aging impacts the...

    Authors: Claire Fabian, Yahaira Naaldijk, Christiane Leovsky, Adiv A. Johnson, Lukas Rudolph, Carsten Jaeger, Katrin Arnold and Alexandra Stolzing
    Citation: Stem Cell Research & Therapy 2017 8:85
    Content type: Research Published on:

  6. Severe injuries of the uterus may trigger uterine scar formation, ultimately leading to infertility or obstetrical complications. To date, few methods have adequately solved the problem of collagen deposition ...

    Authors: Lu Xu, Lijun Ding, Lei Wang, Yun Cao, Hui Zhu, Jingjie Lu, Xin’an Li, Tianran Song, Yali Hu and Jianwu Dai
    Citation: Stem Cell Research & Therapy 2017 8:84
    Content type: Research Published on:

  7. Bone marrow-derived mesenchymal stromal cells (MSCs) are multipotent cells with a high constitutive level of autophagy and low expression of CD99. Under certain conditions, MSCs may develop tumorigenic propert...

    Authors: Zvenyslava Husak and Michael N. Dworzak
    Citation: Stem Cell Research & Therapy 2017 8:83
    Content type: Research Published on:

  8. Osteoarthritis (OA) of the knee involves degeneration of articular cartilage of the diarthrodial joints. Current treatment options temporarily relieve the joint pain but do not restore the lost cartilage. We r...

    Authors: Hemanth Akkiraju, Padma Pradeepa Srinivasan, Xian Xu, Xinqiao Jia, Catherine B. Kirn Safran and Anja Nohe
    Citation: Stem Cell Research & Therapy 2017 8:82
    Content type: Research Published on:

  9. In contrast to humans in which mesenchymal stem/stromal cell (MSC) therapies are still largely in the clinical trial phase, MSCs have been used therapeutically in horses for over 15 years, thus constituting a ...

    Authors: Cristina L. Esteves, Tara A. Sheldrake, Simone P. Mesquita, Juan J. Pesántez, Timothy Menghini, Lucy Dawson, Bruno Péault and F. Xavier Donadeu
    Citation: Stem Cell Research & Therapy 2017 8:80
    Content type: Research Published on:

  10. Inflammation is a key contributor to central nervous system (CNS) injury such as stroke, and is a major target for therapeutic intervention. Effective treatments for CNS injuries are limited and applicable to ...

    Authors: Elena Redondo-Castro, Catriona Cunningham, Jonjo Miller, Licia Martuscelli, Sarah Aoulad-Ali, Nancy J. Rothwell, Cay M. Kielty, Stuart M. Allan and Emmanuel Pinteaux
    Citation: Stem Cell Research & Therapy 2017 8:79
    Content type: Research Published on:

  11. Pluripotent stem cells (PSCs) such as embryonic stem cells and induced pluripotent stem cells are promising target cells for cell regenerative medicine together with recently advanced technology of in-vitro di...

    Authors: Seok-Jin Kang, Young-Il Park, So-Ryeon Hwang, Hee Yi, Nga Tham, Hyun-Ok Ku, Jae-Young Song and Hwan-Goo Kang
    Citation: Stem Cell Research & Therapy 2017 8:78
    Content type: Research Published on:

  12. Cryopreservation has been extensively applied to the long-term storage of a diverse range of biological materials. However, no comprehensive study is currently available on the cryopreservation of periodontal ...

    Authors: Mengying Li, Cheng Feng, Xiuge Gu, Qin He and Fulan Wei
    Citation: Stem Cell Research & Therapy 2017 8:77
    Content type: Research Published on:

  13. Glioblastoma (GBM), a highly aggressive brain tumor, contains a subpopulation of glioblastoma stem-like cells (GSCs) that play roles in tumor maintenance, invasion, and therapeutic resistance. GSCs are therefo...

    Authors: Rebeca Piatniczka Iglesia, Mariana Brandão Prado, Lilian Cruz, Vilma Regina Martins, Tiago Góss Santos and Marilene Hohmuth Lopes
    Citation: Stem Cell Research & Therapy 2017 8:76
    Content type: Research Published on:

  14. The administration of cisplatin is limited due to its nephrotoxic side effects, and prevention of this nephrotoxicity of cisplatin is difficult. Mesenchymal stem cell (MSC)-derived exosomes have been implicate...

    Authors: Bingying Wang, Haoyuan Jia, Bin Zhang, Juanjuan Wang, Cheng Ji, Xueming Zhu, Yongmin Yan, Lei Yin, Jing Yu, Hui Qian and Wenrong Xu
    Citation: Stem Cell Research & Therapy 2017 8:75
    Content type: Research Published on:

  15. Human umbilical cord blood (hUCB) cell therapy is a promising treatment for ischemic stroke. The effects of hyperacute stem cell transplantation on cerebrovascular function in ischemic stroke are, however, not...

    Authors: Lei Huang, Yichu Liu, Jianfei Lu, Bianca Cerqueira, Vivek Misra and Timothy Q. Duong
    Citation: Stem Cell Research & Therapy 2017 8:74
    Content type: Research Published on:

  16. Human induced pluripotent stem cells (hiPSCs) play roles in both disease modelling and regenerative medicine. It is critical that the genomic integrity of the cells remains intact and that the DNA repair syste...

    Authors: Pavel Simara, Lenka Tesarova, Daniela Rehakova, Pavel Matula, Stanislav Stejskal, Ales Hampl and Irena Koutna
    Citation: Stem Cell Research & Therapy 2017 8:73
    Content type: Research Published on:

  17. The success of developing cardiovascular tissue engineering (CTE) grafts greatly needs a readily available cell substitute for endothelial and interstitial cells. Perinatal annexes have been proposed as a valu...

    Authors: Lei Pu, Mingyao Meng, Jian Wu, Jing Zhang, Zongliu Hou, Hui Gao, Hui Xu, Boyu Liu, Weiwei Tang, Lihong Jiang and Yaxiong Li
    Citation: Stem Cell Research & Therapy 2017 8:72
    Content type: Research Published on:

  18. While it is known that irradiation can induce local and systemic bone loss over time, how focal irradiation induces systemic bone complications remains unclear. Immune cells are thought to be crucial to bone h...

    Authors: Xiaoya Xu, Ruixia Li, Yi Zhou, Qiong Zou, Qiaoling Ding, Jinfeng Wang, Weifang Jin, Guoqiang Hua and Jianjun Gao
    Citation: Stem Cell Research & Therapy 2017 8:71
    Content type: Research Published on:

  19. Mesenchymal stem cells (MSCs) have been studied for the treatment of acute liver failure (ALF) for several years. MSCs may exert their effect via complex paracrine mechanisms. Heme oxygenase (HO) 1, a rate-lim...

    Authors: Zhi-heng Zhang, Wei Zhu, Hao-zhen Ren, Xin Zhao, Shuai Wang, Hu-cheng Ma and Xiao-lei Shi
    Citation: Stem Cell Research & Therapy 2017 8:70
    Content type: Research Published on:

  20. Adipose-derived mesenchymal stem cells (ASCs) are a promising cell therapy to treat inflammatory and immune-mediated diseases. Development of appropriate pre-clinical animal models is critical to determine saf...

    Authors: Kaitlin C. Clark, Fernando A. Fierro, Emily Mills Ko, Naomi J. Walker, Boaz Arzi, Clifford G. Tepper, Heather Dahlenburg, Andrew Cicchetto, Amir Kol, Lyndsey Marsh, William J. Murphy, Nasim Fazel and Dori L. Borjesson
    Citation: Stem Cell Research & Therapy 2017 8:69
    Content type: Research Published on:

  21. Cell therapy of liver diseases with human biliary tree stem cells (hBTSCs) is biased by low engraftment efficiency. Coating the hBTSCs with hyaluronans (HAs), the primary constituents of all stem cell niches, ...

    Authors: Lorenzo Nevi, Guido Carpino, Daniele Costantini, Vincenzo Cardinale, Olga Riccioni, Sabina Di Matteo, Fabio Melandro, Pasquale Bartolomeo Berloco, Lola Reid, Eugenio Gaudio and Domenico Alvaro
    Citation: Stem Cell Research & Therapy 2017 8:68
    Content type: Research Published on:

  22. The robust generation of human hematopoietic progenitor cells from induced or embryonic pluripotent stem cells would be beneficial for multiple areas of research, including mechanistic studies of hematopoiesis...

    Authors: Yekaterina Galat, Svetlana Dambaeva, Irina Elcheva, Aaruni Khanolkar, Kenneth Beaman, Philip M. Iannaccone and Vasiliy Galat
    Citation: Stem Cell Research & Therapy 2017 8:67
    Content type: Research Published on:

  23. Successful implementation of rapidly advancing regenerative medicine approaches has led to high demand for readily available cellular suspensions. In particular, multipotent stromal cells (MSCs) of placental o...

    Authors: Denys Pogozhykh, Olena Pogozhykh, Volodymyr Prokopyuk, Larisa Kuleshova, Anatoliy Goltsev, Rainer Blasczyk and Thomas Mueller
    Citation: Stem Cell Research & Therapy 2017 8:66
    Content type: Research Published on:

  24. Poor bone quality, increased fracture risks, and impaired bone healing are orthopedic comorbidities of type 1 diabetes (T1DM). Standard osteogenic growth factor treatments are inadequate in fully rescuing reta...

    Authors: Tera M. Filion, Jordan D. Skelly, Henry Huang, Dale L. Greiner, David C. Ayers and Jie Song
    Citation: Stem Cell Research & Therapy 2017 8:65
    Content type: Research Published on:

  25. Osteoarthritis (OA) is the most common joint disease worldwide. In the past decade, mesenchymal stem cells (MSCs) have been used widely for the treatment of OA. A potential mechanism of MSC-based therapies has...

    Authors: Yu Zhu, Yuchen Wang, Bizeng Zhao, Xin Niu, Bin Hu, Qing Li, Juntao Zhang, Jian Ding, Yunfeng Chen and Yang Wang
    Citation: Stem Cell Research & Therapy 2017 8:64
    Content type: Research Published on:

  26. Urethral reconstruction is one of the great surgical challenges for urologists. A cell-based tissue-engineered urethra may be an alternative for patients who have complicated long strictures and need urethral ...

    Authors: Yang Liu, Wenjun Ma, Bo Liu, Yangcai Wang, Jiaqiang Chu, Geng Xiong, Lianju Shen, Chunlan Long, Tao Lin, Dawei He, Denis Butnaru, Lyundup Alexey, Yuanyuan Zhang, Deying Zhang and Guanghui Wei
    Citation: Stem Cell Research & Therapy 2017 8:63
    Content type: Research Published on:

  27. Due to their ease of isolation, differentiation capabilities, and immunomodulatory properties, the therapeutic potential of mesenchymal stem cells (MSCs) has been assessed in numerous pre-clinical and clinical...

    Authors: Dario Gerace, Rosetta Martiniello-Wilks, Najah Therese Nassif, Sara Lal, Raymond Steptoe and Ann Margaret Simpson
    Citation: Stem Cell Research & Therapy 2017 8:62
    Content type: Review Published on:

  28. Experiments have previously demonstrated the therapeutic potential of mobilized dental pulp stem cells (MDPSCs) for complete pulp regeneration. The aim of the present pilot clinical study is to assess the safe...

    Authors: Misako Nakashima, Koichiro Iohara, Masashi Murakami, Hiroshi Nakamura, Yayoi Sato, Yoshiko Ariji and Kenji Matsushita
    Citation: Stem Cell Research & Therapy 2017 8:61
    Content type: Research Published on:

  29. Distinctive structures called crypts harbor intestinal epithelial stem cells (IESCs) which generate progenitor and terminally differentiated cells in the intestinal epithelium. Mammalian IESCs and their daught...

    Authors: Can-Ze Huang, Ji-Hao Xu, Wa Zhong, Zhong-Sheng Xia, Si-Yi Wang, Di Cheng, Jie-Yao Li, Ting-Feng Wu, Qi-Kui Chen and Tao Yu
    Citation: Stem Cell Research & Therapy 2017 8:60
    Content type: Research Published on:

  30. Intracerebral transplantation of human induced pluripotent stem cells (iPSCs) can ameliorate behavioral deficits in animal models of stroke. How the ischemic lesion affects the survival of the transplanted cel...

    Authors: Carlos de la Rosa-Prieto, Cecilia Laterza, Ana Gonzalez-Ramos, Somsak Wattananit, Ruimin Ge, Olle Lindvall, Daniel Tornero and Zaal Kokaia
    Citation: Stem Cell Research & Therapy 2017 8:59
    Content type: Research Published on:

  31. Mesenchymal stromal cells (MSCs) have been extensively investigated in the field of regenerative medicine. It is known that the success of MSC-based therapies depends primarily on effective cell delivery to th...

    Authors: Luisa H. A. Silva, Fernanda F. Cruz, Marcelo M. Morales, Daniel J. Weiss and Patricia R. M. Rocco
    Citation: Stem Cell Research & Therapy 2017 8:58
    Content type: Review Published on:

  32. Application of genetically modified hematopoietic stem cells is increasingly mooted as a clinically relevant approach to protein replacement therapy, immune tolerance induction or conditions where both outcome...

    Authors: Kunal H. Bhatt, Rajeev Rudraraju, Jeremy F. Brooks, Ji-Won Jung, Ryan Galea, James W. Wells and Raymond J. Steptoe
    Citation: Stem Cell Research & Therapy 2017 8:57
    Content type: Research Published on:

  33. CD117 is expressed on double-negative (DN; CD4–CD8–) cells (Nat Rev Immunol 14:529–545; 2014), but whether it is expressed in other stages and its subsequent functions are unclear. We used an improved method of f...

    Authors: Yang Wei, Zhansheng Hu, Wen Gu, Gang Liu, Bingyin Shi, Enqi Liu and Tie Liu
    Citation: Stem Cell Research & Therapy 2017 8:56
    Content type: Research Published on:

  34. Human umbilical cord mesenchymal stem cells (hUCMSCs) are a type of pluripotent stem cell which are isolated from the umbilical cord of newborns. hUCMSCs have great therapeutic potential. We designed this expe...

    Authors: Jia Li, QiuXian Mao, JingJun He, HaoQing She, Zhi Zhang and ChunYan Yin
    Citation: Stem Cell Research & Therapy 2017 8:55
    Content type: Research Published on:

  35. Cardiotoxicity remains an important concern in drug discovery. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have become an attractive platform to evaluate cardiotoxicity. However, the consiste...

    Authors: Qi Zhao, Xijie Wang, Shuyan Wang, Zheng Song, Jiaxian Wang and Jing Ma
    Citation: Stem Cell Research & Therapy 2017 8:54
    Content type: Research Published on:

  36. Mesenchymal stem/stromal cells (MSCs) represent an attractive tool for cell-based cancer therapy mainly because of their ability to migrate to tumors and to release bioactive molecules. However, the impact of ...

    Authors: Simone Pacioni, Quintino Giorgio D’Alessandris, Stefano Giannetti, Liliana Morgante, Valentina Coccè, Arianna Bonomi, Mariachiara Buccarelli, Luisa Pascucci, Giulio Alessandri, Augusto Pessina, Lucia Ricci-Vitiani, Maria Laura Falchetti and Roberto Pallini
    Citation: Stem Cell Research & Therapy 2017 8:53
    Content type: Research Published on:

  37. Myocardial microvascular loss after myocardial infarction (MI) remains a therapeutic challenge. Autologous stem cell therapy was considered as an alternative; however, it has shown modest benefits due to the i...

    Authors: Gemma Vilahur, Blanca Oñate, Judit Cubedo, Maria Teresa Béjar, Gemma Arderiu, Esther Peña, Laura Casaní, Manuel Gutiérrez, Antoni Capdevila, Guillem Pons-Lladó, Francesc Carreras, Alberto Hidalgo and Lina Badimon
    Citation: Stem Cell Research & Therapy 2017 8:52
    Content type: Research Published on:

  38. A devastating condition that leads to trauma-related morbidity, multiple rib fractures, remain a serious unmet clinical need. Systemic administration of mesenchymal stem cells (MSCs) has been shown to regenera...

    Authors: Doron Cohn Yakubovich, Dmitriy Sheyn, Maxim Bez, Yeshai Schary, Eran Yalon, Afeef Sirhan, May Amira, Alin Yaya, Sandra De Mel, Xiaoyu Da, Shiran Ben-David, Wafa Tawackoli, Eric J. Ley, Dan Gazit, Zulma Gazit and Gadi Pelled
    Citation: Stem Cell Research & Therapy 2017 8:51
    Content type: Research Published on:

  39. Authors: Jun Hee Lee, Seung Taek Ji, Jaeho Kim, Satoshi Takaki, Takayuki Asahara, Young-Joon Hong and Sang-Mo Kwon
    Citation: Stem Cell Research & Therapy 2017 8:50
    Content type: Erratum Published on:

    The original article was published in Stem Cell Research & Therapy 2016 7:158

  41. Mesenchymal stem cells (MSCs) have potent immunomodulatory effects on multiple immune cells and have great potential in treating immune disorders. Induced pluripotent stem cells (iPSCs) serve as an unlimited a...

    Authors: Wen-Xiang Gao, Yue-Qi Sun, Jianbo Shi, Cheng-Lin Li, Shu-Bin Fang, Dan Wang, Xue-Quan Deng, Weiping Wen and Qing-Ling Fu
    Citation: Stem Cell Research & Therapy 2017 8:48
    Content type: Research Published on:

  42. Mesenchymal stromal cells (MSCs) have emerged as a more beneficial alternative to conventional therapy and may offer a potential cure for unmet medical needs. MSCs are known to possess strong immunomodulatory ...

    Authors: Charan Thej, Balamurugan Ramadasse, Ankita Walvekar, Anish S. Majumdar and Sudha Balasubramanian
    Citation: Stem Cell Research & Therapy 2017 8:47
    Content type: Research Published on:

  43. Human amnion epithelial cells (hAECs) are clonogenic and have been proposed to reduce inflammatory-induced tissue injury. Perturbation of the immune response is implicated in the pathogenesis of perinatal brai...

    Authors: Bryan Leaw, Dandan Zhu, Jean Tan, Ruth Muljadi, Mohamed I. Saad, Joanne C. Mockler, Euan M. Wallace, Rebecca Lim and Mary Tolcos
    Citation: Stem Cell Research & Therapy 2017 8:46
    Content type: Research Published on:

  44. The applications for fat grafting have increased recently, within both regenerative and reconstructive surgery. Although fat harvesting, processing and injection techniques have been extensively studied and st...

    Authors: Jajini Varghese, Michelle Griffin, Afshin Mosahebi and Peter Butler
    Citation: Stem Cell Research & Therapy 2017 8:45
    Content type: Review Published on:

  45. The role of p53 as “a guardian of the genome” has been well established in somatic cells. However, its role in pluripotent stem cells remains much more elusive. Here, we discuss research progress in understand...

    Authors: Tongxiang Lin and Yi Lin
    Citation: Stem Cell Research & Therapy 2017 8:44
    Content type: Review Published on:

  46. Angiogenesis, the process in which new blood vessels are formed from preexisting ones, is highly dependent on the presence of classical angiogenic factors. Recent evidence suggests that axonal guidance protein...

    Authors: Catalina P. Prieto, María Carolina Ortiz, Andrea Villanueva, Cynthia Villarroel, Sandra S. Edwards, Matías Elliott, José Lattus, Sócrates Aedo, Daniel Meza, Pablo Lois and Verónica Palma
    Citation: Stem Cell Research & Therapy 2017 8:43
    Content type: Research Published on:

  47. Intra-articular injection of mesenchymal stem cells (MSCs) is efficacious in osteoarthritis therapy. A direct comparison of the response of the synovial joint to intra-articular injection of autologous versus ...

    Authors: Amanda-Jo Joswig, Alexis Mitchell, Kevin J. Cummings, Gwendolyn J. Levine, Carl A. Gregory, Roger Smith III and Ashlee E. Watts
    Citation: Stem Cell Research & Therapy 2017 8:42
    Content type: Research Published on:

  48. Use of decellularized tissues has become popular in tissue engineering applications as the natural extracellular matrix can provide necessary physical cues that help induce the restoration and development of f...

    Authors: Adam J. Mellott, Heather E. Shinogle, Jennifer G. Nelson-Brantley, Michael S. Detamore and Hinrich Staecker
    Citation: Stem Cell Research & Therapy 2017 8:41
    Content type: Research Published on:

  49. Anal sphincter defects are a major cause of fecal incontinence causing negative effects on daily life, social interactions, and mental health. Because human adipose-derived stromal/stem cells (hADSCs) are easi...

    Authors: Arash Sarveazad, Graham L. Newstead, Rezvan Mirzaei, Mohammad Taghi Joghataei, Mehrdad Bakhtiari, Asrin Babahajian and Bahar Mahjoubi
    Citation: Stem Cell Research & Therapy 2017 8:40
    Content type: Research Published on:

    The Commentary to this article has been published in Stem Cell Research & Therapy 2018 9:115

  50. Magnesium is essential for numerous physiological functions. Magnesium exists mostly in bone and the amount is dynamically regulated by skeletal remodeling. Accelerating bone mass loss occurs when magnesium in...

    Authors: Yu-Tzu Tsao, Ya-Yi Shih, Yu-An Liu, Yi-Shiuan Liu and Oscar K. Lee
    Citation: Stem Cell Research & Therapy 2017 8:39
    Content type: Research Published on:
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