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  1. Autologous mesenchymal stem cells (MSCs) are an attractive concept in regenerative medicine, but their mechanism of action remains poorly defined. No immune response is reported after in vivo injection of allogen...

    Authors: Yasmin Z Paterson, Nicola Rash, Elaine R Garvican, Romain Paillot and Deborah J Guest
    Citation: Stem Cell Research & Therapy 2014 5:90
    Content type: Research Published on:

  2. MicroRNAs regulate target gene expression post-transcriptionally in a myriad of cell types and play critical roles in diverse physiological and pathological processes, including cardiomyocyte development, diff...

    Authors: Manoj K Gupta and Tata Nageswara Rao
    Citation: Stem Cell Research & Therapy 2014 5:89
    Content type: Commentary Published on:

  3. Mesenchymal stromal/stem cells (MSCs) for clinical use have largely been isolated from the bone marrow, although isolation of these cells from many different adult and fetal tissues has been reported as well. ...

    Authors: Priyanka Swamynathan, Parvathy Venugopal, Suresh Kannan, Charan Thej, Udaykumar Kolkundar, Swaroop Bhagwat, Malancha Ta, Anish Sen Majumdar and Sudha Balasubramanian
    Citation: Stem Cell Research & Therapy 2014 5:88
    Content type: Research Published on:

  4. Motor neurons are cells located in specific areas of the central nervous system, such as brain cortex (upper motor neurons), brain stem, and spinal cord (lower motor neurons), which maintain control over volun...

    Authors: Irene Faravelli, Monica Bucchia, Paola Rinchetti, Monica Nizzardo, Chiara Simone, Emanuele Frattini and Stefania Corti
    Citation: Stem Cell Research & Therapy 2014 5:87
    Content type: Review Published on:

  6. Rapid progress in biotechnology has introduced a host of pressing ethical and policy issues pertaining to stem cell research. In this review, we provide an overview of the most significant issues with which th...

    Authors: Nancy MP King and Jacob Perrin
    Citation: Stem Cell Research & Therapy 2014 5:85
    Content type: Review Published on:

  8. Chronic renal failure is an important clinical problem with significant socioeconomic impact worldwide. Despite advances in renal replacement therapies and organ transplantation, poor quality of life for dialy...

    Authors: Alfonso Eirin and Lilach O Lerman
    Citation: Stem Cell Research & Therapy 2014 5:83
    Content type: Review Published on:

  10. New therapeutic options are necessary for patients with chronic Chagas disease, a leading cause of heart failure in Latin American countries. Stem cell therapy focused on improving cardiac function is a promis...

    Authors: Daniela Nascimento Silva, Bruno Solano de Freitas Souza, Carine Machado Azevedo, Juliana Fraga Vasconcelos, Rejane Hughes Carvalho, Milena Botelho Pereira Soares and Ricardo Ribeiro dos Santos
    Citation: Stem Cell Research & Therapy 2014 5:81
    Content type: Research Published on:

  11. The mortality of rhabdomyolysis-induced acute kidney injury (AKI) is still high, as there is no effective therapy. It has been shown that bone marrow-derived mesenchymal stem cells (MSCs) can induce M2 macroph...

    Authors: Yanqiu Geng, Li Zhang, Bo Fu, Jianrong Zhang, Quan Hong, Jie Hu, Diangeng Li, Congjuan Luo, Shaoyuan Cui, Fei Zhu and Xiangmei Chen
    Citation: Stem Cell Research & Therapy 2014 5:80
    Content type: Research Published on:

  12. Pathophysiologic changes associated with diabetes impair new blood vessel formation and wound healing. Mesenchymal stem cells derived from adipose tissue (ASCs) have been used clinically to promote healing, al...

    Authors: Robert C Rennert, Michael Sorkin, Michael Januszyk, Dominik Duscher, Revanth Kosaraju, Michael T Chung, James Lennon, Anika Radiya-Dixit, Shubha Raghvendra, Zeshaan N Maan, Michael S Hu, Jayakumar Rajadas, Melanie Rodrigues and Geoffrey C Gurtner
    Citation: Stem Cell Research & Therapy 2014 5:79
    Content type: Research Published on:

  13. The optimization of an organic scaffold for specific types of applications and cells is vital to successful tissue engineering. In this study, we investigated the effects of a new fibrin sealant derived from s...

    Authors: Vinícius P O Gasparotto, Fernanda C Landim-Alvarenga, Alexandre L R Oliveira, Gustavo Ferreira Simões, João F Lima-Neto, Benedito Barraviera and Rui S Ferreira Jr
    Citation: Stem Cell Research & Therapy 2014 5:78
    Content type: Research Published on:

  14. In the present study, we established a novel in vitro coculture model to evaluate the influence of osteoarthritis (OA) cartilage explants on the composition of newly produced matrix and chondrogenic differentiati...

    Authors: Michaela Leyh, Andreas Seitz, Lutz Dürselen, Hans-Robert Springorum, Peter Angele, Anita Ignatius, Joachim Grifka and Susanne Grässel
    Citation: Stem Cell Research & Therapy 2014 5:77
    Content type: Research Published on:

  15. Mesenchymal stem cell-conditioned medium (MSC-CM) has been shown to have protective effects against various cellular-injury models. This mechanism of protection, however, has yet to be elucidated. Recently, ex...

    Authors: Cheau Yih Tan, Ruenn Chai Lai, Winnie Wong, Yock Young Dan, Sai-Kiang Lim and Han Kiat Ho
    Citation: Stem Cell Research & Therapy 2014 5:76
    Content type: Research Published on:

  16. Posttranscriptional control of mRNA by microRNA (miRNA) has been implicated in the regulation of diverse biologic processes from directed differentiation of stem cells through organism development. We describe...

    Authors: Vilas Wagh, Alexander Pomorski, Karlijn J Wilschut, Sebastian Piombo and Harold S Bernstein
    Citation: Stem Cell Research & Therapy 2014 5:75
    Content type: Research Published on:

  17. Mesenchymal stem cells (MSCs) reside in a variety of tissues and provide a stromal role in regulating progenitor cell function. Current studies focus on identifying the specific factors in the niche that can a...

    Authors: Michael De Lisio, Tor Jensen, Richard A Sukiennik, Heather D Huntsman and Marni D Boppart
    Citation: Stem Cell Research & Therapy 2014 5:74
    Content type: Research Published on:

  20. Insulin-like growth factors (IGFs), IGF binding proteins (IGFBPs) and angiopoietin-like proteins (ANGPTLs) can enhance the ex vivo expansion of hematopoietic stem cells (HSCs) when used with a standard cytokine c...

    Authors: Xiubo Fan, Florence PH Gay, Francesca WI Lim, Justina ML Ang, Pat PY Chu, Sudipto Bari and William YK Hwang
    Citation: Stem Cell Research & Therapy 2014 5:71
    Content type: Research Published on:

  21. We have assessed the utility of autologous mesenchymal stem cell (MSC) peripheral vein infusion as a possible therapeutic modality for patients with end-stage liver diseases.

    Authors: Hosny Salama, Abdel-Rahman N Zekri, Eman Medhat, Shereen A Al Alim, Ola S Ahmed, Abeer A Bahnassy, Mai M Lotfy, Rasha Ahmed and Sherief Musa
    Citation: Stem Cell Research & Therapy 2014 5:70
    Content type: Research Published on:

  22. Engineered bladder tissues, created with autologous bladder cells seeded on biodegradable scaffolds, are being developed for use in patients who need cystoplasty. However, in individuals with organ damage from...

    Authors: Danian Qin, Ting Long, Junhong Deng and Yuanyuan Zhang
    Citation: Stem Cell Research & Therapy 2014 5:69
    Content type: Review Published on:

  23. Male infertility management has made significant progress during the past three decades, especially after the introduction of intracytoplasmic sperm injection in 1992. However, many boys and men still suffer f...

    Authors: Hooman Sadri-Ardekani and Anthony Atala
    Citation: Stem Cell Research & Therapy 2014 5:68
    Content type: Review Published on:

  24. Periodontitis is initiated and sustained by bacteria. However, the mechanism of bacteria induced periodontitis is still unknown. We hypothesized that bacterial components can affect the functions of stem cells...

    Authors: Chenghua Li, Bei Li, Zhiwei Dong, Li Gao, Xiaoning He, Li Liao, Chenghu Hu, Qintao Wang and Yan Jin
    Citation: Stem Cell Research & Therapy 2014 5:67
    Content type: Research Published on:

  25. Bone marrow mesenchymal stem cells (BMSCs) possess low immunogenicity and immunosuppression as an allograft, can differentiate into insulin-producing cells (IPCs) by in vitro induction, and may be a valuable cell...

    Authors: Yihua Zhang and Zhongying Dou
    Citation: Stem Cell Research & Therapy 2014 5:66
    Content type: Research Published on:

  26. This is the first study evaluating the interactions of human adipose tissue derived stem cells (ADSCs) and human squamous cell carcinoma cells (SCCs), with regard to a prospective cell-based skin regenerative ...

    Authors: Eva Koellensperger, Felix Gramley, Fabian Preisner, Uwe Leimer, Guenter Germann and Verena Dexheimer
    Citation: Stem Cell Research & Therapy 2014 5:65
    Content type: Research Published on:

  27. Npas4 is a calcium-dependent transcription factor expressed within neurons of the brain where it regulates the expression of several genes that are important for neuronal survival and synaptic plasticity. It i...

    Authors: Thomas S Klaric, Paul Q Thomas, Mirella Dottori, Wai Khay Leong, Simon A Koblar and Martin D Lewis
    Citation: Stem Cell Research & Therapy 2014 5:64
    Content type: Research Published on:

  28. Human adipose-derived stromal cells (hASCs), due to their relative feasibility of isolation and ability to secrete large amounts of angiogenic factors, are being evaluated for regenerative medicine. However, t...

    Authors: Luigi Balducci, Antonella Blasi, Marilisa Saldarelli, Antonio Soleti, Augusto Pessina, Arianna Bonomi, Valentina Coccè, Marta Dossena, Valentina Tosetti, Valentina Ceserani, Stefania Elena Navone, Maria Laura Falchetti, Eugenio Agostino Parati and Giulio Alessandri
    Citation: Stem Cell Research & Therapy 2014 5:63
    Content type: Research Published on:

  31. We previously demonstrated that the lifespan of primary human keratinocytes could be extended indefinitely by culture in the presence of the Rho kinase (ROCK) inhibitor Y-27632. This technique has proven to be...

    Authors: Sandra Chapman, David H McDermott, Kui Shen, Moon Kyoo Jang and Alison A McBride
    Citation: Stem Cell Research & Therapy 2014 5:60
    Content type: Research Published on:

  32. Human multipotent stromal cells (MSCs) isolated from bone marrow or other tissue sources have great potential to treat a wide range of injuries and disorders in the field of regenerative medicine and tissue en...

    Authors: Ian H Bellayr, Jennifer G Catalano, Samir Lababidi, Amy X Yang, Jessica L Lo Surdo, Steven R Bauer and Raj K Puri
    Citation: Stem Cell Research & Therapy 2014 5:59
    Content type: Research Published on:

  33. Because of their pluripotent characteristics, human induced pluripotent stem cells (iPSCs) possess great potential for therapeutic application and for the study of degenerative disorders. These cells are gener...

    Authors: Ying-Chu Lin, Yoshinobu Murayama, Koichiro Hashimoto, Yukio Nakamura, Chang-Shin Lin, Kazunari K Yokoyama and Shigeo Saito
    Citation: Stem Cell Research & Therapy 2014 5:58
    Content type: Review Published on:

  34. Stem cell therapy has recently been introduced to treat patients with type 2 diabetes mellitus (T2DM). However, no data are available on the efficacy and safety of allogeneic Wharton’s Jelly-derived mesenchyma...

    Authors: Xuebin Liu, Pei Zheng, Xiaodong Wang, Guanghui Dai, Hongbin Cheng, Zan Zhang, Rongrong Hua, Xinxin Niu, Jing Shi and Yihua An
    Citation: Stem Cell Research & Therapy 2014 5:57
    Content type: Research Published on:

  35. Stem cells are unspecialized cells that have been a major focus of the field of regenerative medicine, opening new frontiers and regarded as the future of medicine. The ophthalmology branch of the medical scie...

    Authors: Kamesh Dhamodaran, Murali Subramani, Murugeswari Ponnalagu, Reshma Shetty and Debashish Das
    Citation: Stem Cell Research & Therapy 2014 5:56
    Content type: Review Published on:

  36. The cancer stem cell model links neoplastic cells with normal stem cell biology, but little is known on how normal stem cells are transformed into cancer stem cells.

    Authors: Donatella Amendola, Marta Nardella, Loredana Guglielmi, Lidia Cerquetti, Elisabetta Carico, Viola Alesi, Manuela Porru, Carlo Leonetti, Claudia Bearzi, Roberto Rizzi, Igea D’Agnano, Antonio Stigliano, Giuseppe Novelli and Barbara Bucci
    Citation: Stem Cell Research & Therapy 2014 5:55
    Content type: Research Published on:

  37. Although mesenchymal stem cells (MSCs) have antitumor potential in hepatocellular carcinoma and breast cancer cells, the antitumor mechanism of human umbilical cord mesenchymal stem cells (hUCMSCs) in prostate...

    Authors: Ihn Han, Miyong Yun, Eun-Ok Kim, Bonglee Kim, Min-Hyung Jung and Sung-Hoon Kim
    Citation: Stem Cell Research & Therapy 2014 5:54
    Content type: Research Published on:

    The Retraction Note to this article has been published in Stem Cell Research & Therapy 2018 9:354

  38. Different mesenchymal stromal cells (MSC) have been successfully isolated and expanded in vitro and nowadays they are tested in clinical trials for a wide variety of diseases. Whether all MSC express the same cel...

    Authors: Paola Romina Amable, Marcus Vinicius Telles Teixeira, Rosana Bizon Vieira Carias, José Mauro Granjeiro and Radovan Borojevic
    Citation: Stem Cell Research & Therapy 2014 5:53
    Content type: Research Published on:

  39. Gingiva-derived mesenchymal stem cells (GMSCs) have recently been harvested and applied for rebuilding lost periodontal tissue. Enamel matrix derivative (EMD) has been used for periodontal regeneration and the...

    Authors: Shu-Man Wu, Hsien-Chung Chiu, Yu-Tang Chin, Heng-Yi Lin, Cheng-Yang Chiang, Hsiao-Pei Tu, Martin MJ Fu and Earl Fu
    Citation: Stem Cell Research & Therapy 2014 5:52
    Content type: Research Published on:

  40. Short-term neural stem cell (NSC) transplantation improves cognition in Alzheimer’s disease (AD) transgenic mice by enhancing endogenous synaptic connectivity. However, this approach has no effect on the under...

    Authors: Mathew Blurton-Jones, Brian Spencer, Sara Michael, Nicholas A Castello, Andranik A Agazaryan, Joy L Davis, Franz-Josef Müller, Jeanne F Loring, Eliezer Masliah and Frank M LaFerla
    Citation: Stem Cell Research & Therapy 2014 5:46
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2024 15:88

  41. Compromised bone-regenerating capability following a long bone fracture is often the result of reduced host bone marrow (BM) progenitor cell numbers and efficacy. Without surgical intervention, these malunions...

    Authors: Luke Watson, Stephen J Elliman and Cynthia M Coleman
    Citation: Stem Cell Research & Therapy 2014 5:51
    Content type: Review Published on:

  42. Adipose tissue has the unique property of expanding throughout adult life, and angiogenesis is required for its growth. However, endothelial progenitor cells contribute minimally to neovascularization. Because...

    Authors: Amparo Navarro, Severiano Marín, Nicasia Riol, Francisco Carbonell-Uberos and María Dolores Miñana
    Citation: Stem Cell Research & Therapy 2014 5:50
    Content type: Research Published on:

  44. Therapeutic potentials of mesenchymal stem cells (MSCs) from different sources have been evaluated in pre-clinical and clinical settings. Although MSCs from different sources share MSC-specific characteristics...

    Authors: Yongzhao Zhu, Yinxue Yang, Yaolin Zhang, Guiliang Hao, Ting Liu, Libin Wang, Tingting Yang, Qiong Wang, Guangyi Zhang, Jun Wei and Yukui Li
    Citation: Stem Cell Research & Therapy 2014 5:48
    Content type: Research Published on:

  45. Integrating viruses represent robust tools for cellular reprogramming; however, the presence of viral transgenes in induced pluripotent stem cells (iPSCs) is deleterious because it holds the risk of insertiona...

    Authors: Asifiqbal Kadari, Min Lu, Ming Li, Thileepan Sekaran, Rajkumar P Thummer, Naomi Guyette, Vi Chu and Frank Edenhofer
    Citation: Stem Cell Research & Therapy 2014 5:47
    Content type: Method Published on:

  46. Stroke is the second leading cause of death worldwide, claims six lives every 60 seconds, and is a leading cause of adult disability across the globe. Tissue plasminogen activator, the only United States Food ...

    Authors: Neha Karlupia, Nathan C Manley, Kameshwar Prasad, Richard Schäfer and Gary K Steinberg
    Citation: Stem Cell Research & Therapy 2014 5:45
    Content type: Research Published on:

  47. Nasopharyngeal carcinoma (NPC) is the most common cancer originating in the nasopharynx, and is extremely common in southern regions of China. Although the standard combination of radiotherapy and chemotherapy...

    Authors: Pingpin Wei, Man Niu, Suming Pan, Yanhong Zhou, Cijun Shuai, Jing Wang, Shuping Peng and Guiyuan Li
    Citation: Stem Cell Research & Therapy 2014 5:44
    Content type: Review Published on:

  48. Mesenchymal stem cells (MSCs) are multipotent stromal cells originated from bone marrow and other adult tissues. MSCs are capable of differentiating into adipogenic, osteogenic, and chondrogenic lineages. Tran...

    Authors: Sherry Shuyi Wang and Jun Ren
    Citation: Stem Cell Research & Therapy 2014 5:43
    Content type: Commentary Published on:

  49. Acute respiratory distress syndrome (ARDS) is the most common cause of respiratory failure among critically ill subjects, sepsis and severe bacterial pneumonia being its most common causes. The only interventi...

    Authors: Mauricio Rojas, Nayra Cárdenes, Ergin Kocyildirim, John R Tedrow, Eder Cáceres, Robert Deans, Anthony Ting and Christian Bermúdez
    Citation: Stem Cell Research & Therapy 2014 5:42
    Content type: Research Published on:

  50. Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been proposed as an ideal autologous stem cell source for cell-based therapy for myocardial infarction (MI). However, decreased viability and impaired ...

    Authors: Zheng Zhang, Chuanxu Zhao, Bing Liu, Dong Liang, Xing Qin, Xiujuan Li, Rongqing Zhang, Congye Li, Haichang Wang, Dongdong Sun and Feng Cao
    Citation: Stem Cell Research & Therapy 2014 5:33
    Content type: Research Published on:
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Stem Cell Research & Therapy

ISSN: 1757-6512