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  1. Mesenchymal stem cells (MSCs) have been demonstrated to be effective in treating autoimmune diseases including Sjögren’s syndrome (SS). We aim to compare the effects of MSC transplantation (MSCT) and the role ...

    Authors: Bingyu Shi, Jingjing Qi, Genhong Yao, Ruihai Feng, Zhuoya Zhang, Dandan Wang, Chen Chen, Xiaojun Tang, Liwei Lu, Wanjun Chen and Lingyun Sun
    Citation: Stem Cell Research & Therapy 2018 9:308
    Content type: Research Published on:

  2. In the context of regenerative medicine and cellular therapies, the treatment under study often targets a less common disease or condition for which recruitment of a large number of research participants at an...

    Authors: Erika Kleiderman, Audrey Boily, Craig Hasilo and Bartha Maria Knoppers
    Citation: Stem Cell Research & Therapy 2018 9:307
    Content type: Review Published on:

  3. Cardiovascular complications, especially myocardial infarctions (MIs), are the leading mortality cause in diabetic patients. The transplantation of stem cells into damaged hearts has had considerable success a...

    Authors: Xiao He, Meng-Wei Yao, Ming Zhu, Dong-Lan Liang, Wei Guo, Yi Yang, Rong-Seng Zhao, Ting-Ting Ren, Xiang Ao, Wei Wang, Chun-Yu Zeng, Hua-Ping Liang, Dong-po Jiang, Jian Yu and Xiang Xu
    Citation: Stem Cell Research & Therapy 2018 9:306
    Content type: Research Published on:

  4. Autologous urothelial cells are often obtained via bladder biopsy to generate the bio-engineered urethra or bladder, while urine-derived stem cells (USC) can be obtained by a non-invasive approach. The objecti...

    Authors: Qian Wan, Geng Xiong, Guihua Liu, Thomas D. Shupe, Guanghui Wei, Deying Zhang, Dan Liang, Xiongbing Lu, Anthony Atala and Yuanyuan Zhang
    Citation: Stem Cell Research & Therapy 2018 9:304
    Content type: Research Published on:

  5. Hyperbilirubinemia that occurs in pediatric liver diseases such as biliary atresia can result in the development of not only jaundice in the brain, eyes, and skin, but also tooth abnormalities including green ...

    Authors: Haruyoshi Yamaza, Soichiro Sonoda, Kazuaki Nonaka, Toshio Kukita and Takayoshi Yamaza
    Citation: Stem Cell Research & Therapy 2018 9:303
    Content type: Research Published on:

  6. Restoration of damaged tissues through the activation of endogenous progenitors is an attractive therapeutic option. A deep evaluation of the intrinsic stem/progenitor cell properties as well as the reciprocal...

    Authors: Claudia Lo Sicco, Daniele Reverberi, Federico Villa, Ulrich Pfeffer, Rodolfo Quarto, Ranieri Cancedda and Roberta Tasso
    Citation: Stem Cell Research & Therapy 2018 9:300
    Content type: Research Published on:

  7. Medical management of the severe musculocutaneous radiation syndrome involves surgical intervention with debridement of necrotic tissue. Even when skin excision is replaced by specific plastic surgery, treatme...

    Authors: Christine Linard, Michel Brachet, Bruno L’homme, Carine Strup-Perrot, Elodie Busson, Michel Bonneau, Jean-Jacques Lataillade, Eric Bey and Marc Benderitter
    Citation: Stem Cell Research & Therapy 2018 9:299
    Content type: Research Published on:

  9. A single administration of mesenchymal stromal cells (MSCs) has been shown to reduce lung inflammation in experimental elastase-induced emphysema; however, effects were limited in terms of lung-tissue repair a...

    Authors: Hananda A. Poggio, Mariana A. Antunes, Nazareth N. Rocha, Jamil Z. Kitoko, Marcelo M. Morales, Priscilla C. Olsen, Miquéias Lopes-Pacheco, Fernanda F. Cruz and Patricia R. M. Rocco
    Citation: Stem Cell Research & Therapy 2018 9:296
    Content type: Research Published on:

  10. Deer antlers are bony structures that re-grow at very high rates, making them an attractive model for studying rapid bone regeneration.

    Authors: Dai Fei Elmer Ker, Dan Wang, Rashmi Sharma, Bin Zhang, Ben Passarelli, Norma Neff, Chunyi Li, William Maloney, Stephen Quake and Yunzhi Peter Yang
    Citation: Stem Cell Research & Therapy 2018 9:292
    Content type: Research Published on:

  11. Osteonecrosis of the femoral head (ONFH) is a refractory disease that is associated with collapse of the femoral head, with a risk of hip arthroplasty in younger populations. Thus, there has been an increased ...

    Authors: Rui Li, Qiu-Xia Lin, Xue-Zhen Liang, Guang-Bo Liu, He Tang, Yu Wang, Shi-Bi Lu and Jiang Peng
    Citation: Stem Cell Research & Therapy 2018 9:291
    Content type: Review Published on:

  12. Transplantation of allogeneic human cardiac/stem progenitor cells (hCSCs) is currently being tested in several phase I/II clinical trials as a novel and promising therapy for restoration of myocardial tissue f...

    Authors: Maria J Sebastião, Ramón Menta, Margarida Serra, Itziar Palacios, Paula M Alves, Belén Sanchez, Olga DelaRosa, Wilfried Dalemans, Eleuterio Lombardo and Patrícia Gomes-Alves
    Citation: Stem Cell Research & Therapy 2018 9:290
    Content type: Short report Published on:

  14. Stem cells have great potential for tissue regeneration, but before stem cell populations can be used in the clinic, it is crucial that the stem cells have been definitely characterized by a set of specific ma...

    Authors: Louise Bundgaard, Allan Stensballe, Kirstine Juul Elbæk and Lise Charlotte Berg
    Citation: Stem Cell Research & Therapy 2018 9:288
    Content type: Research Published on:

  15. Human-induced pluripotent stem cells (hiPSCs) provide a personalized approach to study conditions and diseases including those of the eye that lack appropriate animal models to facilitate the development of no...

    Authors: Koushik Chakrabarty, Rohit Shetty and Arkasubhra Ghosh
    Citation: Stem Cell Research & Therapy 2018 9:287
    Content type: Review Published on:

  16. During the last decade, mesenchymal stem cells (MSCs) have gained much attention in the field of regenerative medicine due to their capacity to differentiate into different cell types and to promote immunosupp...

    Authors: Denise Philipp, Laura Suhr, Thorsten Wahlers, Yeong-Hoon Choi and Adnana Paunel-Görgülü
    Citation: Stem Cell Research & Therapy 2018 9:286
    Content type: Research Published on:

  17. Diabetic peripheral neurovascular diseases (DPNVs) are complex, lacking effective treatment. Autologous/allogeneic transplantation of adipose-derived stem cells (ADSCs) is a promising strategy for DPNVs. Nonet...

    Authors: Xing Zhang, Jinbao Qin, Xin Wang, Xin Guo, Junchao Liu, Xuhui Wang, Xiaoyu Wu, Xinwu Lu, Weimin Li and Xiaobing Liu
    Citation: Stem Cell Research & Therapy 2018 9:285
    Content type: Research Published on:

  18. Treatment with bone marrow mesenchymal stem cells (BM-MSCs) has been demonstrated to be an excellent cellular-based therapeutic strategy for treating myocardial infarction (MI). However, most of the patients s...

    Authors: Ming Yang, Tong Wen, Haixu Chen, Jingyu Deng, Chao Yang and Zheng Zhang
    Citation: Stem Cell Research & Therapy 2018 9:284
    Content type: Research Published on:

  19. Conventional cell-based bone regeneration suffers from the major disadvantage of limited cell supply, time-consuming in vitro expansion cultures, and limited patient-friendliness related to cell isolation and ...

    Authors: Yang Zhang, Eline C Grosfeld, Winston A Camargo, Hongbo Tang, Angela M P Magri and Jeroen J J P van den Beucken
    Citation: Stem Cell Research & Therapy 2018 9:283
    Content type: Research Published on:

  20. Severe acute pancreatitis (SAP) is an acute abdominal disease characterized by pancreatic necrosis and systemic disease. In a previous study, we showed that bone marrow-derived mesenchymal stem cells (BMSCs) c...

    Authors: Daohai Qian, Guodong Song, Zhilong Ma, Guannan Wang, Lei Jin, Minghua Hu, Zhenshun Song and Xiaoming Wang
    Citation: Stem Cell Research & Therapy 2018 9:282
    Content type: Research Published on:

  21. Mesenchymal stem cells (MSCs) are known to home to injured and inflamed regions via the bloodstream to assist in tissue regeneration in response to signals of cellular damage. However, the factors and mechanis...

    Authors: Yu-Chien Guo, Yun-Hsuan Chiu, Chie-Pein Chen and Hwai-Shi Wang
    Citation: Stem Cell Research & Therapy 2018 9:281
    Content type: Research Published on:

  22. Mesenchymal stem cells (MSCs) derived from bone marrow have potent stabilizing effects for the treatment of acute respiratory distress syndrome (ARDS). However, low efficiency and survival in MSC homing to inj...

    Authors: Shan-Shan Meng, Xiu-Ping Xu, Wei Chang, Zhong-Hua Lu, Li-Li Huang, Jing-Yuan Xu, Ling Liu, Hai-Bo Qiu, Yi Yang and Feng-Mei Guo
    Citation: Stem Cell Research & Therapy 2018 9:280
    Content type: Research Published on:

  23. Generation of induced photoreceptors holds promise for in vitro modeling of intractable retinal diseases. Retinitis pigmentosa is an inherited retinal dystrophy that leads to visual impairment. The EYS gene was r...

    Authors: Yuko Seko, Masaki Iwanami, Kiyoko Miyamoto-Matsui, Shimpei Takita, Noriyuki Aoi, Akihiro Umezawa and Seishi Kato
    Citation: Stem Cell Research & Therapy 2018 9:279
    Content type: Research Published on:

  24. Mesenchymal stem cells (MSCs) isolated from adult tissues (Ad-MSCs) have shown great promise for use in regenerative medicine. However, their poor in vitro expansion capacity and tissue scarcity have been majo...

    Authors: William D’Angelo, Bohan Chen, Chandan Gurung and Yan-Lin Guo
    Citation: Stem Cell Research & Therapy 2018 9:278
    Content type: Research Published on:

  25. Transplantation of pancreatic β cells generated in vitro from pluripotent stem cells (hPSCs) such as embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) has been proposed as an alternative th...

    Authors: Hideomi Ida, Tomohiko Akiyama, Keiichiro Ishiguro, Sravan K. Goparaju, Yuhki Nakatake, Nana Chikazawa-Nohtomi, Saeko Sato, Hiromi Kimura, Yukihiro Yokoyama, Masato Nagino, Minoru S. H. Ko and Shigeru B. H. Ko
    Citation: Stem Cell Research & Therapy 2018 9:277
    Content type: Research Published on:

  26. Physical loading is necessary to maintain bone tissue integrity. Loading-induced fluid shear is recognised as one of the most potent bone micromechanical cues and has been shown to direct stem cell osteogenesi...

    Authors: Elena Stavenschi, Michele A. Corrigan, Gillian P. Johnson, Mathieu Riffault and David A. Hoey
    Citation: Stem Cell Research & Therapy 2018 9:276
    Content type: Research Published on:

  27. Human decidua basalis mesenchymal stem/multipotent stromal cells (DBMSCs) inhibit endothelial cell activation by inflammation induced by monocytes. This property makes them a promising candidate for cell-based th...

    Authors: M. A. Alshabibi, T. Khatlani, F. M. Abomaray, A. S. AlAskar, B. Kalionis, S. A. Messaoudi, R. Khanabdali, A. O. Alawad and M. H. Abumaree
    Citation: Stem Cell Research & Therapy 2018 9:275
    Content type: Research Published on:

  28. To date, several trials have reported the use of mesenchymal stem cell (MSC) implantation for osteonecrosis of the femoral head (ONFH). However, the clinical outcomes have not been conclusive. This study compa...

    Authors: Joon Soon Kang, Young Ju Suh, Kyoung Ho Moon, Jun Sung Park, Tae Hoon Roh, Myung Hoon Park and Dong Jin Ryu
    Citation: Stem Cell Research & Therapy 2018 9:274
    Content type: Research Published on:

  29. Mesenchymal stem cells (MSCs) are known for their ability to induce the conversion of conventional T cells (Tconvs) into induced regulatory T cells (iTregs) in specific inflammatory contexts. Stable Foxp3 expr...

    Authors: Maryam Khosravi, Ali Bidmeshkipour, José L. Cohen, Ali Moravej, Suzzan Hojjat-Assari, Sina Naserian and Mohammad Hossein Karimi
    Citation: Stem Cell Research & Therapy 2018 9:273
    Content type: Research Published on:

  31. Mesenchymal stromal cells (MSCs) are an essential element of the bone marrow (BM) microenvironment, playing a crucial function in regulating hematopoietic stem cell proliferation and differentiation. Recent fi...

    Authors: Giulia Corradi, Carmen Baldazzi, Darina Očadlíková, Giovanni Marconi, Sarah Parisi, Nicoletta Testoni, Carlo Finelli, Michele Cavo, Antonio Curti and Marilena Ciciarello
    Citation: Stem Cell Research & Therapy 2018 9:271
    Content type: Research Published on:

  32. The original article [1] contains an error in Fig. 5e whereby the immunofluorescence of ΔNp63α in the ME group is incorrectly presented; thus, the corrected figure is shown ahead.

    Authors: X. Y. Zhao, H. T. Xie, C. Y. Duan, J. Li and M. C. Zhang
    Citation: Stem Cell Research & Therapy 2018 9:270
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:256

  33. The original article [1] contains an error regarding the erroneous inclusion of 3 μl as a parameter in the x-axis of Fig. 2c; the correct version of Fig. 2c can instead be seen below.

    Authors: Siyuan Zha, Zhen Li, Qing Cao, Fei Wang and Fang Liu
    Citation: Stem Cell Research & Therapy 2018 9:269
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:224

  34. Efficient and sustained hematopoietic recovery after hematopoietic stem cell or bone marrow transplantation is supported by paracrine signaling from specific subpopulations of mesenchymal stromal cells (MSCs)....

    Authors: Frances D. Liu, Kimberley Tam, Novalia Pishesha, Zhiyong Poon and Krystyn J. Van Vliet
    Citation: Stem Cell Research & Therapy 2018 9:268
    Content type: Research Published on:

  36. Adipose derived stem cells can be stimulated to produce a growth factor rich secretome which enhances axon regeneration. In this study we investigated the importance of exosomes, extracellular vesicles release...

    Authors: Rosanna C Ching, Mikael Wiberg and Paul J Kingham
    Citation: Stem Cell Research & Therapy 2018 9:266
    Content type: Research Published on:

  37. In the bone marrow, MSCs reside in a hypoxic milieu (1–5% O2) that is thought to preserve their multipotent state. Typically, in vitro expansion of MSCs is performed under normoxia (~ 21% O2), a process that has ...

    Authors: Ben Antebi, Luis A Rodriguez II, Kerfoot P Walker III, Amber M Asher, Robin M Kamucheka, Lucero Alvarado, Arezoo Mohammadipoor and Leopoldo C Cancio
    Citation: Stem Cell Research & Therapy 2018 9:265
    Content type: Research Published on:

  38. The original article [1] contains a number of small errors which the authors would like to clarify:

    Authors: Bushra Memon, Manale Karam, Sara Al-Khawaga and Essam M. Abdelalim
    Citation: Stem Cell Research & Therapy 2018 9:262
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:15

  39. The original article [1] contains numerous value errors in the graphs in Fig. 2b regarding the markers describing the values for total tubule length and mean tubule length without aprotinin at 2.5 mg/ml concen...

    Authors: Severin Mühleder, Karoline Pill, Mira Schaupper, Krystyna Labuda, Eleni Priglinger, Pablo Hofbauer, Verena Charwat, Uwe Marx, Heinz Redl and Wolfgang Holnthoner
    Citation: Stem Cell Research & Therapy 2018 9:261
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:35

  40. The original article [1] contains a major error carried across the captions of Tables 1, 2, and 3. In each table caption, the data were expressed as “mean ± standard deviation (SD)”; unfortunately, the authors...

    Authors: Fa-Ming Chen, Li-Na Gao, Bei-Min Tian, Xi-Yu Zhang, Yong-Jie Zhang, Guang-Ying Dong, Hong Lu, Qing Chu, Jie Xu, Yang Yu, Rui-Xin Wu, Yuan Yin, Songtao Shi and Yan Jin
    Citation: Stem Cell Research & Therapy 2018 9:260
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2016 7:33

  41. The original article [1] contained a minor error regarding the mean diameter of the alginate microcapsules described in relation to Fig. 4 in the Results section. The microcapsules had an actual mean diameter ...

    Authors: Vitor Hugo Santos, João Pedro Hübbe Pfeifer, Jaqueline Brandão de Souza, Betsabéia Heloisa Gentilha Milani, Rogério Antonio de Oliveira, Marjorie Golim Assis, Elenice Deffune, Andrei Moroz and Ana Liz Garcia Alves
    Citation: Stem Cell Research & Therapy 2018 9:259
    Content type: Correction Published on:

    The original article was published in BMC Veterinary Research 2018 14:114

  42. Normal human breast epithelial cells are maintained by the proliferation and differentiation of different human breast epithelial progenitors (HBEPs). However, these progenitor subsets can only be obtained at ...

    Authors: Sumanta Chatterjee, Pratima Basak, Edward Buchel, Leigh C. Murphy and Afshin Raouf
    Citation: Stem Cell Research & Therapy 2018 9:264
    Content type: Short report Published on:

  43. With the development of regenerative medicine, a variety of mesenchymal stem cells (MSCs) are increasingly considered for the treatment of premature ovarian failure (POF). Reportedly, bone marrow-derived MSCs ...

    Authors: Yantao He, Dongmei Chen, Lingling Yang, Qiaoni Hou, Huiming Ma and Xian Xu
    Citation: Stem Cell Research & Therapy 2018 9:263
    Content type: Review Published on:

  44. Skeletal muscle regeneration is possible thanks to unipotent stem cells, which are satellite cells connected to the myofibers. Populations of stem cells other than muscle-specific satellite cells are considere...

    Authors: Kamil Kowalski, Matthieu Dos Santos, Pascal Maire, Maria A. Ciemerych and Edyta Brzoska
    Citation: Stem Cell Research & Therapy 2018 9:258
    Content type: Research Published on:

  45. Inducing donor-specific immunological tolerance, which avoids the complications of long-term immunosuppression, is an important goal in organ transplantation. Interleukin-35 (IL-35), a cytokine identified in 2...

    Authors: Hao Guo, Baozhu Li, Wei Wang, Na Zhao and Haopeng Gao
    Citation: Stem Cell Research & Therapy 2018 9:254
    Content type: Review Published on:

  46. In-vitro spermatogenesis in mammalian species is considered an important topic in reproductive biology. New strategies for achieving a complete version of spermatogenesis ex vivo have been conducted using an o...

    Authors: Keykavos Gholami, Gholamreza Pourmand, Morteza Koruji, Sepideh Ashouri and Mehdi Abbasi
    Citation: Stem Cell Research & Therapy 2018 9:249
    Content type: Research Published on:

  47. Stem cells are increasingly seen as a solution for many health challenges for an ageing population. However, their potential benefits in the clinic are currently curtailed by technical challenges such as high ...

    Authors: Richard Harrison, Hilda Anaid Lugo Leija, Stephanie Strohbuecker, James Crutchley, Sarah Marsh, Chris Denning, Alicia El Haj and Virginie Sottile
    Citation: Stem Cell Research & Therapy 2018 9:248
    Content type: Research Published on:

  48. Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related progressive disease characterized by reduced bone mass and increased risk of fractures. At the cellular level, the ...

    Authors: Arantza Infante and Clara I. Rodríguez
    Citation: Stem Cell Research & Therapy 2018 9:244
    Content type: Review Published on:

  49. Non-adherent or ultra-low attachment three-dimensional (3D) culture, also called sphere formation assay, has been widely used to assess the malignant phenotype and stemness potential of transformed or cancer c...

    Authors: Weijie Gao, Dinglan Wu, Yuliang Wang, Zhu Wang, Chang Zou, Yong Dai, Chi-Fai Ng, Jeremy Yuen-Chun Teoh and Franky Leung Chan
    Citation: Stem Cell Research & Therapy 2018 9:243
    Content type: Method Published on:

  50. Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disease with no cure or treatment to stop disease progression. Because ALS represents an urgent unmet medical need, a significant number of therapeutics...

    Authors: Luis Barbeito
    Citation: Stem Cell Research & Therapy 2018 9:241
    Content type: Commentary Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:152

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