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  1. Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease for which age is the most important risk factor. Different mechanisms associated with aging, including stem cell dysfunction, have been described t...

    Authors: Nayra Cárdenes, Diana Álvarez, Jacobo Sellarés, Yating Peng, Catherine Corey, Sophie Wecht, Seyed Mehdi Nouraie, Swaroop Shanker, John Sembrat, Marta Bueno, Sruti Shiva, Ana L. Mora and Mauricio Rojas
    Citation: Stem Cell Research & Therapy 2018 9:257
    Content type: Research Published on:

  2. Cultivated oral mucosal epithelial cells (OMECs) are widely used in the treatment of limbal stem cell deficiency (LSCD) for their ocular reconstruction capability. As the most important component of the limbal...

    Authors: Xin-Yue Zhao, Hua-Tao Xie, Chao-Ye Duan, Jing Li and Ming-Chang Zhang
    Citation: Stem Cell Research & Therapy 2018 9:256
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:270

  3. Through recent studies, the onset of acute pancreatitis in pancreatic acinar cells (PACs) and the regulatory role of PACs in severe acute pancreatitis (SAP) have been revealed. During the early stages of pancr...

    Authors: Qiang Li, Woo-Jin Song, Min-Ok Ryu, Aryung Nam, Ju-Hyun An, Jin-Ok Ahn, Dong Ha Bhang, Yun Chan Jung and Hwa-Young Youn
    Citation: Stem Cell Research & Therapy 2018 9:255
    Content type: Research Published on:

  4. Bone marrow mesenchymal stem cells (BMSC) transfer has been attempted as a therapeutic strategy in experimental lung injury and fibrosis. Reduction of neutrophilic infiltration is one of the mechanisms involve...

    Authors: XiaoSan Su, Liu Yang, YanFeng Yin, Jie Huang, Fei Qiao, Yu Fang, Lu Yu, YinYin Wang, KaiHua Zhou and Jun Wang
    Citation: Stem Cell Research & Therapy 2018 9:253
    Content type: Research Published on:

  5. The increasing number of patients with ovarian insufficiency due to autoimmune disorders, genetic predisposition, or iatrogenic effects of treatment such as cancer therapies necessitates an urgent measure to f...

    Authors: Ashraf Hassanpour, Tahereh Talaei-Khozani, Elias Kargar-Abarghouei, Vahid Razban and Zahra Vojdani
    Citation: Stem Cell Research & Therapy 2018 9:252
    Content type: Research Published on:

  6. It is known that, following a physiological insult, bone marrow-derived mesenchymal stem cells (MSCs) mobilize and home to the site of injury. However, the effect of injury on the function of endogenous MSCs i...

    Authors: Ben Antebi, Kerfoot P. Walker III, Arezoo Mohammadipoor, Luis A. Rodriguez, Robbie K. Montgomery, Andriy I. Batchinsky and Leopoldo C. Cancio
    Citation: Stem Cell Research & Therapy 2018 9:251
    Content type: Research Published on:

  7. Cell therapy for degenerative diseases aims at rescuing tissue damage by delivery of precursor cells. Thus far, this strategy has been mostly unsuccessful due to massive loss of donor cells shortly after trans...

    Authors: Giuliana Di Rocco, Silvia Baldari, Antonietta Gentile, Maurizio Capogrossi and Gabriele Toietta
    Citation: Stem Cell Research & Therapy 2018 9:250
    Content type: Research Published on:

  8. WNT5A is known to be involved in the pathogenesis of osteoarthritis. This study investigated the molecular mechanism of exosomal miR-92a-3p and WNT5A in chondrogenesis and cartilage degeneration.

    Authors: Guping Mao, Ziji Zhang, Shu Hu, Zhiqi Zhang, Zongkun Chang, Zhiyu Huang, Weiming Liao and Yan Kang
    Citation: Stem Cell Research & Therapy 2018 9:247
    Content type: Research Published on:

  9. This study investigated the therapeutic effects of MSC-derived exosomes (MSC-Exos) on erectile function in a rat model of cavernous nerve injury (CNI).

    Authors: Xi Ouyang, Xiaoyan Han, Zehong Chen, Jiafeng Fang, Xuna Huang and Hongbo Wei
    Citation: Stem Cell Research & Therapy 2018 9:246
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:508

  10. Neurodegenerative disorders have a complex pathology and are characterized by a progressive loss of neuronal architecture in the brain or spinal cord. Neuroprotective agents have demonstrated promising results...

    Authors: Syed Shadab Raza, Aurel Popa Wagner, Yawer S. Hussain and Mohsin Ali Khan
    Citation: Stem Cell Research & Therapy 2018 9:245
    Content type: Review Published on:

  11. Androgen deprivation (AD) as the first-line treatment for advanced prostate cancer (PCa) is insufficient for a long-term effect. Castration resistance remains the greatest obstacle in PCa clinical therapy. Mes...

    Authors: Yang Yu, Qingyun Zhang, Chengzhong Ma, Xue Yang, Rui Lin, Hongxiang Zhang, Yan Liu, Zhipeng Han and Jiwen Cheng
    Citation: Stem Cell Research & Therapy 2018 9:242
    Content type: Research Published on:

  12. Premature ovarian failure (POF) is a severe complication associated with chemotherapy for female patients of childbearing age. A previous study has shown that bone marrow-derived mesenchymal stem cells (MSCs) ...

    Authors: Xiaoying Chen, Qing Wang, Xinran Li, Qingru Wang, Jiaxin Xie and Xiafei Fu
    Citation: Stem Cell Research & Therapy 2018 9:240
    Content type: Research Published on:

  13. Cell therapy constitutes an attractive alternative to treat stress urinary incontinence. Although promising results have been demonstrated in this field, the procedure requires further optimization. The most c...

    Authors: Anna Burdzinska, Bartosz Dybowski, Weronika Zarychta-Wiśniewska, Agnieszka Kulesza, Marta Butrym, Radoslaw Zagozdzon, Agnieszka Graczyk-Jarzynka, Piotr Radziszewski, Zdzislaw Gajewski and Leszek Paczek
    Citation: Stem Cell Research & Therapy 2018 9:239
    Content type: Research Published on:

  14. Mesenchymal stem/stromal cells derived from chorionic villi of human term placentae (pMSCs) protect human endothelial cells from injury induced by hydrogen peroxide (H2O2). In diabetes, elevated levels of glucose...

    Authors: Y. S. Basmaeil, A. M. Al Subayyil, T. Khatlani, E. Bahattab, M. Al-Alwan, F. M. Abomaray, B. Kalionis, M. A. Alshabibi, A. S. AlAskar and M. H. Abumaree
    Citation: Stem Cell Research & Therapy 2018 9:238
    Content type: Research Published on:

  15. Mesenchymal stem cells (MSCs) play an anti-inflammatory role by secreting certain bioactive molecules to exert their therapeutic effects for disease treatment. However, the underlying mechanism of MSCs in chro...

    Authors: Junyu Fan, Xiaojun Tang, Qian Wang, Zhuoya Zhang, Shufang Wu, Wenchao Li, Shanshan Liu, Genhong Yao, Hongwei Chen and Lingyun Sun
    Citation: Stem Cell Research & Therapy 2018 9:237
    Content type: Research Published on:

  16. In this review we present current evidence on the possibility of umbilical cord tissue cryopreservation for subsequent clinical use. Protocols for obtaining umbilical cord-derived vessels, Wharton’s jelly-base...

    Authors: Irina Arutyunyan, Timur Fatkhudinov and Gennady Sukhikh
    Citation: Stem Cell Research & Therapy 2018 9:236
    Content type: Review Published on:

  17. Cell therapy with bone marrow (BM)-derived progenitors has emerged as a promising therapeutic for refractory angina (RA) patients. In the present study, we evaluated the safety and preliminary efficacy of tran...

    Authors: Beatrice Bassetti, Corrado Carbucicchio, Valentina Catto, Elisa Gambini, Erica Rurali, Alberto Bestetti, Giuseppe Gaipa, Daniela Belotti, Fabrizio Celeste, Matteo Parma, Stefano Righetti, Lorenza Biava, Maurizio Arosio, Alice Bonomi, Piergiuseppe Agostoni, Paolo Scacciatella…
    Citation: Stem Cell Research & Therapy 2018 9:235
    Content type: Research Published on:

  19. In an earlier pilot study with 10 women, we investigated a new approach for therapy of faecal incontinence (FI) due to obstetric trauma, involving ultrasound-guided injection of autologous skeletal muscle-deri...

    Authors: Andrea Frudinger, Rainer Marksteiner, Johann Pfeifer, Eva Margreiter, Johannes Paede and Marco Thurner
    Citation: Stem Cell Research & Therapy 2018 9:233
    Content type: Research Published on:

  20. Periodontal ligament stem cells (PDLSCs) are considered as candidate cells for the regeneration of periodontal and alveolar bone tissues. Antisense to the cerebellar degeneration-related protein 1 transcript (...

    Authors: Xiaobei Li, Yunfei Zheng, Yan Zheng, Yiping Huang, Yixin Zhang, Lingfei Jia and Weiran Li
    Citation: Stem Cell Research & Therapy 2018 9:232
    Content type: Research Published on:

  21. An understanding of the mechanism underlying adipogenic differentiation of human bone marrow-derived mesenchymal stem cells (hMSCs) will provide new therapeutic approaches for many diseases, including osteopor...

    Authors: Yangling Wang, Lei Yang, Xiaofeng Liu, Tao Hong, Tao Wang, Aiwu Dong, Jiangxiong Li, Xiaoyuan Xu and Lingling Cao
    Citation: Stem Cell Research & Therapy 2018 9:231
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:62

  22. Inner ear hair cells as mechanoreceptors are extremely important for hearing. Defects in hair cells are a major cause of deafness. Induced pluripotent stem cells (iPSCs) are promising for regenerating inner ea...

    Authors: Jianling Chen, Fanfan Hong, Cui Zhang, Liang Li, Cuicui Wang, Haosong Shi, Yong Fu and Jinfu Wang
    Citation: Stem Cell Research & Therapy 2018 9:230
    Content type: Research Published on:

  23. The original article [1] contained two minor errors affecting the labelling of Fig. 3d and Figs. 6b & 6c; these errors have now been corrected in the respective figures in the original article.

    Authors: Emily R. Moore, Ya Xing Zhu, Han Seul Ryu and Christopher R. Jacobs
    Citation: Stem Cell Research & Therapy 2018 9:229
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:190

  24. Glioma, which accounts for more than 30% of primary central nervous system tumours, is characterised by symptoms such as headaches, epilepsy, and blurred vision. Glioblastoma multiforme is the most aggressive,...

    Authors: Qing Zhang, Wei Xiang, Dong-ye Yi, Bing-zhou Xue, Wan-wan Wen, Ahmed Abdelmaksoud, Nan-xiang Xiong, Xiao-bing Jiang, Hong-yang Zhao and Peng Fu
    Citation: Stem Cell Research & Therapy 2018 9:228
    Content type: Review Published on:

  27. Acute kidney injury (AKI) remains a worldwide public health issue due to its increasing incidence, significant mortality, and lack of specific target-orientated therapy. Developments in mesenchymal stem cell (...

    Authors: Lingfei Zhao, Chenxia Hu, Ping Zhang, Hua Jiang and Jianghua Chen
    Citation: Stem Cell Research & Therapy 2018 9:225
    Content type: Review Published on:

  28. Nicotinamide adenine dinucleotide (NAD+) is a critical molecule involved in various biological functions. Poly (ADP-ribose) polymerase 1 (PARP1) and sirtuin 1 (SIRT1) affect cellular NAD+ levels and play essentia...

    Authors: Siyuan Zha, Zhen Li, Qing Cao, Fei Wang and Fang Liu
    Citation: Stem Cell Research & Therapy 2018 9:224
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:269

  29. Deep vein thrombosis (DVT) is caused by blood clotting in the deep veins. Thrombosis resolution and recanalization can be accelerated by endothelial progenitor cells. In this report, we investigated the effect...

    Authors: Jiacheng Sun, Zhiwei Zhang, Teng Ma, Ziying Yang, Jinlong Zhang, Xuan Liu, Da Lu, Zhenya Shen, Junjie Yang and Qingyou Meng
    Citation: Stem Cell Research & Therapy 2018 9:223
    Content type: Research Published on:

    The Retraction Note to this article has been published in Stem Cell Research & Therapy 2019 10:162

  30. The original article [1] contained a small typo affecting the co-author, Mohammed Al-Hawwas’s name. This error has now been corrected.

    Authors: Nimshitha Pavathuparambil Abdul Manaph, Mohammed Al-Hawwas, Larisa Bobrovskaya, Patrick T. Coates and Xin-Fu Zhou
    Citation: Stem Cell Research & Therapy 2018 9:222
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:189

  31. Tooth agenesis, one of the most common developmental anomalies, can affect the function and esthetics of patients. The aim of the present study was to identify genetic clues for familial tooth agenesis and exp...

    Authors: Tianyi Xin, Ting Zhang, Qian Li, Tingting Yu, Yunyan Zhu, Ruili Yang and Yanheng Zhou
    Citation: Stem Cell Research & Therapy 2018 9:221
    Content type: Research Published on:

  32. Mesenchymal stromal cell (MSC)-based therapy is a promising strategy for preventing the progression of chronic kidney disease (CKD), with the potential to induce tissue regeneration. In search of the best cell...

    Authors: Cinzia Rota, Marina Morigi, Domenico Cerullo, Martino Introna, Ornella Colpani, Daniela Corna, Chiara Capelli, Ton J. Rabelink, Danielle G. Leuning, Daniela Rottoli, Ariela Benigni, Carlamaria Zoja and Giuseppe Remuzzi
    Citation: Stem Cell Research & Therapy 2018 9:220
    Content type: Research Published on:

  33. Irradiation-induced kidney damage is inevitable during radiotherapeutic practice, which limits effective radiotherapy doses on tumor treatment. In the present study, the role of mTOR complex 1 (mTORC1) signali...

    Authors: Lijian Shao, Wuping Yang, Rui Xu, Shuqin Zhu, Yanqiu Huang, Huan Li, Xincheng Wu, Mengzhen Yue, Xiaoliang Xiong, Xiaowen Chen, Bohai Kuang, Guangqin Fan, Qingxian Zhu and Huihong Zeng
    Citation: Stem Cell Research & Therapy 2018 9:219
    Content type: Research Published on:

  35. Skin is an organ that plays an important role as a physical barrier and has many other complex functions. Skin mimetics may be useful for studying the pathophysiology of diseases in vitro and for repairing les...

    Authors: Yena Kim, Narae Park, Yeri Alice Rim, Yoojun Nam, Hyerin Jung, Kijun Lee and Ji Hyeon Ju
    Citation: Stem Cell Research & Therapy 2018 9:217
    Content type: Research Published on:

  36. Although many reports show that various kinds of stem cells have the ability to recover the function of premature ovarian insufficiency (POI), few studies are associated with the mechanism of stem cell treatme...

    Authors: Boxian Huang, Jiafeng Lu, Chenyue Ding, Qinyan Zou, Wei Wang and Hong Li
    Citation: Stem Cell Research & Therapy 2018 9:216
    Content type: Research Published on:

  37. The effects of electromagnetic fields (EMF) on bone nonunion have been reported for many years. Many studies and randomized controlled trials have demonstrated that EMF exhibited benefits in curing delayed uni...

    Authors: Chang Tu, Yifan Xiao, Yongzhuang Ma, Hua Wu and Mingyu Song
    Citation: Stem Cell Research & Therapy 2018 9:215
    Content type: Research Published on:

  38. Several studies have confirmed that gold nanoparticles (AuNPs) of specific concentration and size exert a boosting effect on cell proliferation; however, the mechanism through which this effect occurs remains ...

    Authors: Chen Li, Zhuoquan Li, Yan Zhang, Abdel Hamid Fathy and Min Zhou
    Citation: Stem Cell Research & Therapy 2018 9:214
    Content type: Research Published on:

  39. Autologous grafting, despite some disadvantages, is still considered the gold standard for reconstruction of maxillofacial bone defects. The aim of this study was to evaluate bone regeneration using bone marro...

    Authors: Cecilie Gjerde, Kamal Mustafa, Sølve Hellem, Markus Rojewski, Harald Gjengedal, Mohammed Ahmed Yassin, Xin Feng, Siren Skaale, Trond Berge, Annika Rosen, Xie-Qi Shi, Aymen B. Ahmed, Bjørn Tore Gjertsen, Hubert Schrezenmeier and Pierre Layrolle
    Citation: Stem Cell Research & Therapy 2018 9:213
    Content type: Research Published on:

  40. Adipose-derived mesenchymal stem cells (ADSCs) have been extensively explored as a promising therapeutic agent due to their differentiation, proliferation and migration abilities. The epigenetic mechanisms tha...

    Authors: Chongyang Shen, Qingli Quan, Chuan Yang, Yueqiang Wen and Hong Li
    Citation: Stem Cell Research & Therapy 2018 9:212
    Content type: Research Published on:

  41. Differentiation of human induced pluripotent stem cells (hiPSCs) into hepatocytes has important clinical significance in providing a new stem cell source for cell therapy of terminal liver disease. The differe...

    Authors: Ziran Xu, Xia He, Xu Shi, Yuhan Xia, Xiaomei Liu, Haitao Wu, Pengdong Li, Hongyu Zhang, Weisi Yin, Xiubo Du, Lisha Li and Yulin Li
    Citation: Stem Cell Research & Therapy 2018 9:211
    Content type: Research Published on:

  42. Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects female fertility. However, with the lack of a corresponding research model, the pathology mechanism of PCOS is poorly ...

    Authors: Zheying Min, Qian Gao, Xiumei Zhen, Yong Fan, Tao Tan, Rong Li, Yue Zhao and Yang Yu
    Citation: Stem Cell Research & Therapy 2018 9:210
    Content type: Research Published on:

  43. Human endometrial epithelia undergo injury repair and regeneration with the menstrual cycle; however, mechanisms underpinning the roles of endometrial epithelial cells in endometrial lesions and regeneration r...

    Authors: Dandan Li, Hui Li, Ying Wang, Ahmed Eldomany, Jing Wu, Chao Yuan, Jing Xue, Juan Shi, Yuanyuan Jia, Chunfang Ha, Shuxia Han, Xiaoming Liu, Jiali Yang and Dan Liu
    Citation: Stem Cell Research & Therapy 2018 9:209
    Content type: Short report Published on:

  44. The aim of this study was to investigate if epigenetically modified human mesenchymal stromal cells (hMSCs) can regulate the Th17-related immune responses.

    Authors: Kyoung-Woon Kim, Hye Joung Kim, Bo-Mi Kim, Yong-Rim Kwon, Hae-Rim Kim and Yoo-Jin Kim
    Citation: Stem Cell Research & Therapy 2018 9:208
    Content type: Research Published on:

  45. Adipose tissue-derived stem cells are considered to be a promising source in the field of cell therapy and regenerative medicine. In addition to direct cell replacement using adipose tissue or purified stem ce...

    Authors: Barbara Bellei, Emilia Migliano, Marinella Tedesco, Silvia Caputo, Federica Papaccio, Gianluca Lopez and Mauro Picardo
    Citation: Stem Cell Research & Therapy 2018 9:207
    Content type: Research Published on:

  46. Deletions and mutations in the SHANK3 gene are strongly associated with autism spectrum disorder and underlie the autism-associated disorder Phelan–McDermid syndrome. SHANK3 is a scaffolding protein found at the ...

    Authors: Samuel E. Taylor, Ruth D. Taylor, Jack Price and Laura C. Andreae
    Citation: Stem Cell Research & Therapy 2018 9:206
    Content type: Research Published on:

  47. Hematopoietic lineage cells derived from human pluripotent stem cells (hPSCs) hold great promise for the treatment of hematological diseases and providing sufficient cells for immune therapy. However, a simple...

    Authors: Fuyu Duan, Rujin Huang, Fengzhi Zhang, Yonglin Zhu, Lin Wang, Xia Chen, Lufeng Bai, Wei Guo, Sophia Chia-Ning Chang, Xiaoyu Hu and Jie Na
    Citation: Stem Cell Research & Therapy 2018 9:205
    Content type: Research Published on:

  48. As the prevalence of therapeutic approaches involving transplanted cells increases, so does the need to noninvasively track the cells to determine their homing patterns. Of particular interest is the fate of t...

    Authors: Sean K. Sweeney, Gohar S. Manzar, Nicholas Zavazava and Jose G. Assouline
    Citation: Stem Cell Research & Therapy 2018 9:204
    Content type: Research Published on:

  49. Patients with scarred vocal folds (congenitally or following phonosurgery) are currently difficult to treat and present a dysphonia, often disabling in daily life. Several therapies are available on the market...

    Authors: Alexia Mattei, Jérémy Magalon, Baptiste Bertrand, Fanny Grimaud, Joana Revis, Mélanie Velier, Julie Veran, Patrick Dessi, Florence Sabatier and Antoine Giovanni
    Citation: Stem Cell Research & Therapy 2018 9:202
    Content type: Short report Published on:

  50. Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and mortality. Heart failure remains a major contributor to this mortality. Despite major therapeutic advances over the past d...

    Authors: Haissam Abou-Saleh, Fouad A. Zouein, Ahmed El-Yazbi, Despina Sanoudou, Christophe Raynaud, Christopher Rao, Gianfranco Pintus, Hassan Dehaini and Ali H. Eid
    Citation: Stem Cell Research & Therapy 2018 9:201
    Content type: Review Published on:
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