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  1. Exosomes derived from the bone marrow mesenchymal stem cell (MSC) have shown great potential in spinal cord injury (SCI) treatment. This research was designed to investigate the therapeutic effects of miR-26a-...

    Authors: Yuyong Chen, Zhenming Tian, Lei He, Can Liu, Nangxiang Wang, Limin Rong and Bin Liu
    Citation: Stem Cell Research & Therapy 2021 12:224
    Content type: Research Published on:

  2. Human amniotic epithelial cells (hAECs) exhibit a strong capability to restore ovarian function in chemotherapy-induced premature ovarian failure (POF). However, the therapeutic efficacy of hAECs is usually af...

    Authors: Yating Huang, Zhijie Ma, Xiaojun Kuang, Qiuwan Zhang, Haiyan Li and Dongmei Lai
    Citation: Stem Cell Research & Therapy 2021 12:223
    Content type: Research Published on:

  3. To explore the adipogenic effects of the small extracellular vesicles derived from the lipoma tissues (sEV-LT), and to find a new cell-free therapeutic approach for adipose tissue regeneration.

    Authors: Pengyu Hong, Xiaoyang Xu, Xin Hu, Hao Yang, Yue Wu, Juan Chen, Kun Li and Zhangui Tang
    Citation: Stem Cell Research & Therapy 2021 12:222
    Content type: Research Published on:

  4. Hypertrophic scar (HS) is a fibro-proliferative disorder of dermis after burn or trauma and usually leads to esthetic disfiguration and functionary impairment for patients. Emerging evidences demonstrated ADSC...

    Authors: Yan Li, Jian Zhang, Jihong Shi, Kaituo Liu, Xujie Wang, Yanhui Jia, Ting He, Kuo Shen, Yunchuan Wang, Jiaqi Liu, Wei Zhang, Hongtao Wang, Zhao Zheng and Dahai Hu
    Citation: Stem Cell Research & Therapy 2021 12:221
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:490

  5. Mesenchymal stem cells (MSCs) exert positive effects in chronic wounds. However, critical parameters, such as the most effective administration routes, remain unclear. Accordingly, the purpose of this study wa...

    Authors: Jianxin Yan, Jiaji Liang, Yingxuan Cao, Mariya M. El Akkawi, Xuan Liao, Xiaojia Chen, Chengzhi Li, Kecheng Li, Guanghui Xie and Hongwei Liu
    Citation: Stem Cell Research & Therapy 2021 12:220
    Content type: Research Published on:

  7. Hepatic ischaemia-reperfusion injury (HIRI) is inevitable in complicated liver surgery and is a major factor leading to postoperative complications and liver dysfunction. Studies have shown that the paracrine ...

    Authors: Zhihui Jiao, Yajun Ma, Qianzhen Zhang, Yue Wang, Tao Liu, Xiaoning Liu, Chenxi Piao, Boyang Liu and Hongbin Wang
    Citation: Stem Cell Research & Therapy 2021 12:218
    Content type: Research Published on:

  8. Despite many recent advances on cancer novel therapies, researchers have yet a long way to cure cancer. They have to deal with tough challenges before they can reach success. Nonetheless, it seems that recentl...

    Authors: Faroogh Marofi, Safa Tahmasebi, Heshu Sulaiman Rahman, Denis Kaigorodov, Alexander Markov, Alexei Valerievich Yumashev, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Rebar N. Mohammed, Mostafa Jarahian, Roza Motavalli and Farhad Motavalli Khiavi
    Citation: Stem Cell Research & Therapy 2021 12:217
    Content type: Review Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:443

  9. Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are syndromes of acute respiratory failure with extremely high mortality and few effective treatments. Mesenchymal stem cells (MSCs) may r...

    Authors: Wenjun Peng, Meijia Chang, Yuanyuan Wu, Wensi Zhu, Lin Tong, Ge Zhang, Qin Wang, Jie Liu, Xiaoping Zhu, Tingting Cheng, Yijia Li, Xi Chen, Dong Weng, Sanhong Liu, Hongwei Zhang, Yao Su…
    Citation: Stem Cell Research & Therapy 2021 12:216
    Content type: Research Published on:

  10. Dysfunction of mesenchymal stem cells (MSCs) is recognized as critical to the pathogenesis of glucocorticoid-induced osteoporosis (GIO), suggesting the potential of MSC-targeting interventions for this disorde...

    Authors: Gang Wang, Fengbin Wang, Lecheng Zhang, Chao Yan and Yuelei Zhang
    Citation: Stem Cell Research & Therapy 2021 12:215
    Content type: Research Published on:

  11. The corneal endothelium maintains corneal hydration through the barrier and pump function, while its dysfunction may cause corneal edema and vision reduction. Considering its development from neural crest cell...

    Authors: Yajie Gong, Haoyun Duan, Xin Wang, Can Zhao, Wenjing Li, Chunxiao Dong, Zongyi Li and Qingjun Zhou
    Citation: Stem Cell Research & Therapy 2021 12:214
    Content type: Research Published on:

  12. Hepatic fibrosis is a common complication in transfusion-dependent thalassemia patients. Data on the co-transplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) in beta-thalassemia...

    Authors: Tahereh Rostami, Amir Kasaeian, Nasrollah Maleki, Mohsen Nikbakht, Azadeh Kiumarsi, Seyed Mohammad Tavangar, Amir Pejman Hashemi Taheri, Seied Asadollah Mousavi and Ardeshir Ghavamzadeh
    Citation: Stem Cell Research & Therapy 2021 12:213
    Content type: Research Published on:

  14. The adoptive transfer of natural killer (NK) cells is an emerging therapy in the field of immuno-oncology. In the last 3 decades, NK cells have been utilized to harness the anti-tumor immune response in a wide...

    Authors: Margaret G. Lamb, Hemalatha G. Rangarajan, Brian P. Tullius and Dean A. Lee
    Citation: Stem Cell Research & Therapy 2021 12:211
    Content type: Review Published on:

  15. Stem cells are characterized by their self-renewal and multipotency and have great potential in the therapy of various disorders. However, the blood–brain barrier (BBB) limits the application of stem cells in ...

    Authors: Yu-Ting Zhang, Kai-Jie He, Jin-Bao Zhang, Quan-Hong Ma, Fen Wang and Chun-Feng Liu
    Citation: Stem Cell Research & Therapy 2021 12:210
    Content type: Review Published on:

  16. Several studies have confirmed that mobilizing bone marrow-derived stem cells (BMSCs) ameliorates renal function loss following cisplatin-induced acute kidney injury (AKI). The aim of this study was to explore...

    Authors: Zhi Chen, Xiang Ren, Ruimin Ren, Yonghong Wang and Jiwen Shang
    Citation: Stem Cell Research & Therapy 2021 12:209
    Content type: Research Published on:

  17. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold great promise for regenerative medicine and in drugs screening. Despite displaying key cardiomyocyte phenotypic characteristics, they...

    Authors: Xinyuan Zhang, Liang Ye, Hao Xu, Qin Zhou, Bin Tan, Qin Yi, Liang Yan, Min Xie, Yin Zhang, Jie Tian and Jing Zhu
    Citation: Stem Cell Research & Therapy 2021 12:208
    Content type: Research Published on:

  18. Cesarean scar defect (CSD) is characterized by the presence of fibrotic tissue and decreased muscular density which is induced by cesarean section. Serious CSD may eventually result in infertility or obstetric...

    Authors: Yihui Fan, Junyan Sun, Qiuwan Zhang and Dongmei Lai
    Citation: Stem Cell Research & Therapy 2021 12:207
    Content type: Research Published on:

  19. Glioblastoma (GBM) is the highest-grade form of glioma, as well as one of the most aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior. Despite significant advances in dia...

    Authors: Ana Laura V. Alves, Izabela N. F. Gomes, Adriana C. Carloni, Marcela N. Rosa, Luciane S. da Silva, Adriane F. Evangelista, Rui Manuel Reis and Viviane Aline O. Silva
    Citation: Stem Cell Research & Therapy 2021 12:206
    Content type: Review Published on:

  20. Immortalized, clonal HB1.​F3.​CD21 human neural stem/progenitor cells (NSCs), loaded with therapeutic cargo prior to intraperitoneal (IP) injection, have been ...

    Authors: Rachael Mooney, Wafa Abidi, Jennifer Batalla-Covello, Hoi Wa Ngai, Caitlyn Hyde, Diana Machado, Asma Abdul-Majid, Yanan Kang, Mohamed Hammad, Linda Flores, Greg Copeland, Thanh Dellinger, Ernest Han, Jacob Berlin and Karen S. Aboody
    Citation: Stem Cell Research & Therapy 2021 12:205
    Content type: Research Published on:

  21. Severe, steroid-resistant asthma (SSRA) is a serious clinical problem in asthma management. Affected patients have severe clinical symptoms, worsened quality of life, and do not respond to steroid, a mainstay ...

    Authors: Bing Dong, Chao Wang, Jing Zhang, Jinrong Zhang, Yinuo Gu, Xiaoping Guo, Xu Zuo, He Pan, Alan Chen-Yu Hsu, Guoqiang Wang and Fang Wang
    Citation: Stem Cell Research & Therapy 2021 12:204
    Content type: Research Published on:

  22. Mesenchymal stem cells (MSCs) provide potential treatments for peritoneal fibrosis. However, MSCs cultured in media containing serum bring risks of infection and other problems. In this study, we compared the ...

    Authors: Kohei Nagasaki, Ayumu Nakashima, Ryo Tamura, Naoki Ishiuchi, Kiyomasa Honda, Toshinori Ueno, Shigehiro Doi, Yukio Kato and Takao Masaki
    Citation: Stem Cell Research & Therapy 2021 12:203
    Content type: Research Published on:

  23. The low survival rate or dysfunction of extracellular matrix (ECM)-based engineered organs caused by the adverse effects of unfavourable local microenvironments on seed cell viability and stemness, especially ...

    Authors: Jiayu Zhang, Tingting Lan, Xue Han, Yuchan Xu, Li Liao, Li Xie, Bo Yang, Weidong Tian and Weihua Guo
    Citation: Stem Cell Research & Therapy 2021 12:202
    Content type: Research Published on:

  24. Cholangiocyte senescence is an important pathological process in diseases such as primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). Stem cell/induced pluripotent stem cell-derived exoso...

    Authors: Wenyi Chen, Jiaqi Zhu, Feiyan Lin, Yanping Xu, Bing Feng, Xudong Feng, Xinyu Sheng, Xiaowei Shi, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Lanjuan Li and Hongcui Cao
    Citation: Stem Cell Research & Therapy 2021 12:201
    Content type: Research Published on:

  25. In recent decades, a new method of cellular immunotherapy was introduced based on engineering and empowering the immune effector cells. In this type of immunotherapy, the immune effector cells are equipped wit...

    Authors: Faroogh Marofi, Heshu Sulaiman Rahman, Lakshmi Thangavelu, Aleksey Dorofeev, Favian Bayas-Morejón, Naghmeh Shirafkan, Navid Shomali, Max Stanley Chartrand, Mostafa Jarahian, Ghasem Vahedi, Rebar N. Mohammed, Somayeh Shahrokh, Morteza Akbari and Farhad Motavalli Khiavi
    Citation: Stem Cell Research & Therapy 2021 12:200
    Content type: Review Published on:

  26. The side effects of busulfan on male reproduction are serious, so fertility preservation in children undergoing busulfan treatment is a major worldwide concern. Human placental mesenchymal stem cells (hPMSCs) ...

    Authors: Jiafeng Lu, Zhenxing Liu, Mingkai Shu, Liya Zhang, Wenjuan Xia, Liuna Tang, Jincheng Li, Boxian Huang and Hong Li
    Citation: Stem Cell Research & Therapy 2021 12:199
    Content type: Research Published on:

  27. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is an intractable nonbacterial inflammatory disease. Mesenchymal stem cells (MSCs) derived from human induced pluripotent stem cells (hiPSCs, iMSCs) h...

    Authors: Xufeng Peng, Hailin Guo, Ji Yuan, Yu Chen, Yuguo Xia, Lin Wang, Ying Wang, Yichen Huang, Hua Xie, Yang Wang and Fang Chen
    Citation: Stem Cell Research & Therapy 2021 12:198
    Content type: Research Published on:

  29. The senescence of dermal fibroblasts (DFLs) leads to an imbalance in the synthesis and degradation of extracellular matrix (ECM) proteins, presenting so-called senescence-associated secretory phenotype (SASP),...

    Authors: Xiangnan Zhao, Yue Liu, Pingping Jia, Hui Cheng, Chen Wang, Shang Chen, Haoyan Huang, Zhibo Han, Zhong-Chao Han, Krzysztof Marycz, Xiaoniao Chen and Zongjin Li
    Citation: Stem Cell Research & Therapy 2021 12:196
    Content type: Research Published on:

  30. Propofol can have adverse effects on developing neurons, leading to cognitive disorders, but the mechanism of such an effect remains elusive. Here, we aimed to investigate the effect of propofol on neuronal de...

    Authors: Xiaoqing Fan, Haoran Yang, Lizhu Hu, Delong Wang, Ruiting Wang, Aijun Hao and Xueran Chen
    Citation: Stem Cell Research & Therapy 2021 12:195
    Content type: Research Published on:

  31. While therapeutic success of the limbal tissue or cell transplantation to treat severe cases of limbal stem cell (LSC) deficiency (LSCD) strongly depends on the percentage of LSCs within the transplanted cells...

    Authors: Alexandra Norrick, Jasmina Esterlechner, Elke Niebergall-Roth, Ulf Dehio, Samar Sadeghi, Hannes M. Schröder, Seda Ballikaya, Nicole Stemler, Christoph Ganss, Kathrin Dieter, Ann-Kathrin Dachtler, Patrick Merz, Saadettin Sel, James Chodosh, Claus Cursiefen, Natasha Y. Frank…
    Citation: Stem Cell Research & Therapy 2021 12:194
    Content type: Research Published on:

  32. Life-long peritoneal dialysis (PD) as a renal replacement therapy is limited by peritoneal fibrosis. Previous studies showed immunomodulatory and antifibrotic effects of adipose-derived mesenchymal stem cells ...

    Authors: Chih-Yu Yang, Pu-Yuan Chang, Jun-Yi Chen, Bo-Sheng Wu, An-Hang Yang and Oscar Kuang-Sheng Lee
    Citation: Stem Cell Research & Therapy 2021 12:193
    Content type: Research Published on:

  33. Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical applications have received much attention from the global scientific community in an increasing manner. Firstly, MSCs wer...

    Authors: Alexander Markov, Lakshmi Thangavelu, Surendar Aravindhan, Angelina Olegovna Zekiy, Mostafa Jarahian, Max Stanley Chartrand, Yashwant Pathak, Faroogh Marofi, Somayeh Shamlou and Ali Hassanzadeh
    Citation: Stem Cell Research & Therapy 2021 12:192
    Content type: Review Published on:

  34. The objective was to explore the therapeutic effect of autologous adipose-derived stem cells (ADSCs) combined with ShakeGelâ„¢3D transplantation to activate the BMP7-Smad5 signaling pathway to treat intrauterine...

    Authors: Yun-xia Zhao, Shao-rong Chen, Qiao-yi Huang, Wei-can Chen, Tian Xia, Yan-chuan Shi, Hong-zhi Gao, Qi-yang Shi and Shu Lin
    Citation: Stem Cell Research & Therapy 2021 12:191
    Content type: Research Published on:

  35. Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. Compounds that target tissue-specific transcription factors could ...

    Authors: Mika J. Välimäki, Robert S. Leigh, Sini M. Kinnunen, Alexander R. March, Ana Hernández de Sande, Matias Kinnunen, Markku Varjosalo, Merja Heinäniemi, Bogac L. Kaynak and Heikki Ruskoaho
    Citation: Stem Cell Research & Therapy 2021 12:190
    Content type: Research Published on:

  36. The potential of regenerative medicine to improve human health has led to the rapid expansion of stem cell clinics throughout the world with varying levels of regulation and oversight. This has led to a market...

    Authors: Javier Chavez, Neal A. Shah, Severin Ruoss, Raphael E. Cuomo, Samuel R. Ward and Tim K. Mackey
    Citation: Stem Cell Research & Therapy 2021 12:189
    Content type: Research Published on:

  37. Neural stem cell (NSC) therapy remains one of the most potential approaches for the treatment of neurological disorders. The discovery of human induced pluripotent stem cells (hiPSCs) and the establishment of ...

    Authors: Shuai Li, Huifang Zhao, Xiaobo Han, Bin Ni, Lang He, Omar Mukama, Jean de Dieu Habimana, Zuoxian Lin, Rongqi Huang, Hualin Huang, Chao Tian, Feng Tang and Zhiyuan Li
    Citation: Stem Cell Research & Therapy 2021 12:188
    Content type: Research Published on:

  38. Mesenchymal stromal cells (MSCs) have been studied with increasing intensity as clinicians and researchers strive to understand the ability of MSCs to modulate disease progression and promote tissue regenerati...

    Authors: Ashley A. Krull, Deborah O. Setter, Tania F. Gendron, Sybil C. L. Hrstka, Michael J. Polzin, Joseph Hart, Amel Dudakovic, Nicolas N. Madigan, Allan B. Dietz, Anthony J. Windebank, Andre J. van Wijnen and Nathan P. Staff
    Citation: Stem Cell Research & Therapy 2021 12:187
    Content type: Research Published on:

  39. Ovarian cancer stem cells (OCSC), endowed with tumor-initiating and self-renewal capacity, would account not only for the tumor growth, the peritoneal metastasis, and the relapse, but also for the acquisition ...

    Authors: Kun Wang, Yiyang Wang, Yuanjian Wang, Shujie Liu, Chunyan Wang, Shuo Zhang, Tianli Zhang and Xingsheng Yang
    Citation: Stem Cell Research & Therapy 2021 12:186
    Content type: Research Published on:

  40. This study aims to investigate whether apoptosis repressor with caspase recruitment domain (ARC) could promote survival and enhance osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMS...

    Authors: Longwei Hu, Yang Wang, Hongya Pan, Kathreena Kadir, Jin Wen, Siyi Li and Chenping Zhang
    Citation: Stem Cell Research & Therapy 2021 12:185
    Content type: Research Published on:

  41. Acute lung injury (ALI) and in its severe form, acute respiratory distress syndrome (ARDS), results in increased pulmonary vascular inflammation and permeability and is a major cause of mortality in many criti...

    Authors: Maria Florian, Jia-Pey Wang, Yupu Deng, Luciana Souza-Moreira, Duncan J. Stewart and Shirley H. J. Mei
    Citation: Stem Cell Research & Therapy 2021 12:184
    Content type: Research Published on:

  42. Peripheral arterial disease (PAD) affects millions of people and compromises quality of life. Critical limb ischemia (CLI), which is the most advanced stage of PAD, can cause nonhealing ulcers and strong chron...

    Authors: Yuan-chi Teng, Alfredo Leonardo Porfírio-Sousa, Giulia Magri Ribeiro, Marcela Corso Arend, Lindolfo da Silva Meirelles, Elizabeth Suchi Chen, Daniela Santoro Rosa and Sang Won Han
    Citation: Stem Cell Research & Therapy 2021 12:183
    Content type: Research Published on:

  43. Sjögren’s syndrome (SS) is a chronic autoimmune disease primarily characterized by inflammation in the salivary and lacrimal glands. Activated T cells contribute to disease pathogenesis by producing proinflamm...

    Authors: Mayu Matsumura-Kawashima, Kenichi Ogata, Masafumi Moriyama, Yuka Murakami, Tatsuya Kawado and Seiji Nakamura
    Citation: Stem Cell Research & Therapy 2021 12:182
    Content type: Research Published on:

  44. The bone marrow mesenchymal stem cell (BMSCs)-derived extracellular vesicles (EVs) open up a new avenue for ulcerative colitis (UC) treatment recently, but they are not selectively enriched in targeted tissues...

    Authors: Ting Yu, Si Chu, Xingxing Liu, Junyi Li, Qianyun Chen, Meng Xu, Hui Wu, Mingyue Li, Yalan Dong, Feng Zhu, Haifeng Zhou, Desheng Hu and Heng Fan
    Citation: Stem Cell Research & Therapy 2021 12:181
    Content type: Research Published on:

  45. Severe peripheral nerve injury significantly affects patients’ quality of life and induces neuropathic pain. Neural crest stem cells (NCSCs) exhibit several attractive characteristics for cell-based therapies ...

    Authors: Yang Zhang, Xiang Xu, Yuxin Tong, Xijie Zhou, Jian Du, In Young Choi, Shouwei Yue, Gabsang Lee, Blake N. Johnson and Xiaofeng Jia
    Citation: Stem Cell Research & Therapy 2021 12:180
    Content type: Research Published on:

  46. Radiation-induced skin injury (RISI) is one of the common serious side effects of radiotherapy (RT) for patients with malignant tumors. Mesenchymal stem cells (MSCs) are applied to RISI repair in some clinical...

    Authors: Zhuoqun Fang, Penghong Chen, Shijie Tang, Aizhen Chen, Chaoyu Zhang, Guohao Peng, Ming Li and Xiaosong Chen
    Citation: Stem Cell Research & Therapy 2021 12:179
    Content type: Review Published on:

  47. Premature ovarian insufficiency (POI) is one of the major causes of infertility. We previously demonstrated that transplantation of menstrual blood-derived stromal cells (MenSCs) effectively improved ovarian f...

    Authors: Siwen Zhang, Boxian Huang, Peng Su, Qiyuan Chang, Pingping Li, Aixin Song, Xinyang Zhao, Zhengwei Yuan and Jichun Tan
    Citation: Stem Cell Research & Therapy 2021 12:178
    Content type: Research Published on:

  48. Obesity has received increasing attention because of its widespread worldwide occurrence and many threats to health. Human adipose-derived mesenchymal stem cells (hADSCs) are a critical source of adipocytes. L...

    Authors: Haoying Xu, Yanlei Yang, Linyuan Fan, Luchan Deng, Junfen Fan, Di Li, Hongling Li and Robert Chunhua Zhao
    Citation: Stem Cell Research & Therapy 2021 12:176
    Content type: Research Published on:

  49. Cellular therapy based on mesenchymal stem cells (MSCs) is a promising novel therapeutic strategy for the osteonecrosis of the femoral head (ONFH), which is gradually becoming popular, particularly for early-s...

    Authors: Meiling Zhou, Jiaoya Xi, Yaofeng Cheng, Denglong Sun, Peng Shu, Shuiqing Chi, Shuo Tian and Shunan Ye
    Citation: Stem Cell Research & Therapy 2021 12:175
    Content type: Research Published on:

  50. Osteoporosis (OP) is a metabolic bone disease due to the imbalance of osteogenesis and bone resorption, in which, bone marrow mesenchymal stem cells (BMSCs) have a significant effect as the seed cells. Recent ...

    Authors: Ming Chen, Hui Han, Siqi Zhou, Yinxian Wen and Liaobin Chen
    Citation: Stem Cell Research & Therapy 2021 12:173
    Content type: Research Published on:
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