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  1. Generation of large quantities of endothelial cells is highly desirable for vascular research, for the treatment of ischemia diseases, and for tissue regeneration. To achieve this goal, we developed a simple, ...

    Authors: Fengzhi Zhang, Lin Wang, Yaqian Li, Wei Liu, Fuyu Duan, Rujin Huang, Xi Chen, Sophia Chia-Ning Chang, Yanan Du and Jie Na
    Citation: Stem Cell Research & Therapy 2017 8:6
    Content type: Research Published on:

  2. Mesenchymal stem cells (MSCs) have limited potential of cardiogenic differentiation. In this study, we investigated the influence of long noncoding RNA Braveheart (lncRNA-Bvht) on cardiogenic differentiation o...

    Authors: Jingying Hou, Huibao Long, Changqing Zhou, Shaoxin Zheng, Hao Wu, Tianzhu Guo, Quanhua Wu, Tingting Zhong and Tong Wang
    Citation: Stem Cell Research & Therapy 2017 8:4
    Content type: Research Published on:

  3. Human bone marrow-derived mesenchymal stem cells (MSC) are adult progenitor cells with great potential for application in cell-based therapies. From a cell-based therapy perspective, there are two limitations ...

    Authors: Alessandro Bertolo, Simona Capossela, Gion Fränkl, Martin Baur, Tobias Pötzel and Jivko Stoyanov
    Citation: Stem Cell Research & Therapy 2017 8:3
    Content type: Research Published on:

  4. We have previously reported that induced pluripotent stem cell (iPSC)-mesenchymal stem cells (MSCs) alleviated asthma inflammation in mice. Long noncoding RNAs (lncRNAs) were recently reported as being involve...

    Authors: Shu-Yue Wang, Xing-Liang Fan, Qiu-Ning Yu, Meng-Xia Deng, Yue-Qi Sun, Wen-Xiang Gao, Cheng-Lin Li, Jian-Bo Shi and Qing-Ling Fu
    Citation: Stem Cell Research & Therapy 2017 8:2
    Content type: Research Published on:

  5. Cell therapy for intrinsic urinary sphincter deficiency (ISD) in women has been moderately effective, and improvements are needed. To improve treatment efficacy, it is important to better understand determinat...

    Authors: James Koudy Williams, Ashley Dean, Shannon Lankford, Tracy Criswell, Gopal Badlani and Karl-Erik Andersson
    Citation: Stem Cell Research & Therapy 2017 8:1
    Content type: Research Published on:

  6. Despite diverse pathogenesis, the common pathological change observed in age-related macular degeneration and in most hereditary retinal degeneration (RD) diseases is photoreceptor loss. Photoreceptor replacem...

    Authors: Xi Chen, Zehua Chen, Zhengya Li, Chen Zhao, Yuxiao Zeng, Ting Zou, Caiyun Fu, Xiaoli Liu, Haiwei Xu and Zheng Qin Yin
    Citation: Stem Cell Research & Therapy 2016 7:191
    Content type: Research Published on:

  7. Human embryonic stem cells (hESCs) partially recapitulate early embryonic three germ layer development, allowing testing of potential teratogenic hazards. Because use of hESCs is ethically debated, we investig...

    Authors: Vaibhav Shinde, Sureshkumar Perumal Srinivasan, Margit Henry, Tamara Rotshteyn, Jürgen Hescheler, Jörg Rahnenführer, Marianna Grinberg, Johannes Meisig, Nils Blüthgen, Tanja Waldmann, Marcel Leist, Jan Georg Hengstler and Agapios Sachinidis
    Citation: Stem Cell Research & Therapy 2016 7:190
    Content type: Research Published on:

  8. Although promising for graft-versus-host disease (GvHD) treatment, MSC therapy still faces important challenges. For instance, increasing MSC migratory capacity as well as potentializing immune response suppre...

    Authors: Martha Oliveira-Bravo, Bruno Braga Sangiorgi, Josiane Lilian dos Santos Schiavinato, Juliana Lott Carvalho, Dimas Tadeu Covas, Rodrigo Alexandre Panepucci, Francisco de Assis Rocha Neves, Octávio Luiz Franco, Rinaldo Wellerson Pereira and Felipe Saldanha-Araujo
    Citation: Stem Cell Research & Therapy 2016 7:189
    Content type: Research Published on:

  9. The functionality of stem cells is tightly regulated by cues from the niche, comprising both intrinsic and extrinsic cell signals. Besides chemical and growth factors, biophysical signals are important compone...

    Authors: Lekshmi Krishna, Kamesh Dhamodaran, Chaitra Jayadev, Kaushik Chatterjee, Rohit Shetty, S. S. Khora and Debashish Das
    Citation: Stem Cell Research & Therapy 2016 7:188
    Content type: Review Published on:

  10. Babies born to mothers with pregestational diabetes have a high risk for congenital heart defects (CHD). Embryonic stem cells (ESCs) are excellent in vitro models for studying the effect of high glucose on car...

    Authors: Penghua Yang, Xi Chen, Sunjay Kaushal, E. Albert Reece and Peixin Yang
    Citation: Stem Cell Research & Therapy 2016 7:187
    Content type: Research Published on:

  11. Certain early-phase clinical trials have suggested that bone marrow-derived stem cell transplantation might improve left ventricular function in patients with non-ischaemic dilated cardiomyopathy (NIDCM), wher...

    Authors: Yi Lu, Yiqin Wang, Menglu Lin, Jiale Zhou, Zi Wang, Meng Jiang and Ben He
    Citation: Stem Cell Research & Therapy 2016 7:186
    Content type: Research Published on:

  12. Cartilage formation from self-assembling mesenchymal stem cells (MSCs) in vitro recapitulate important cellular events during mesenchymal condensation that precedes native cartilage development. The goal of th...

    Authors: Johnathan Ng, Yiyong Wei, Bin Zhou, Aonnicha Burapachaisri, Edward Guo and Gordana Vunjak-Novakovic
    Citation: Stem Cell Research & Therapy 2016 7:183
    Content type: Research Published on:

  13. Cartilage does not have the capability to regenerate itself. Therefore, stem cell transplantation is a promising therapeutic approach for impaired cartilage. For stem cell transplantation, in vitro enrichment ...

    Authors: Yeonsue Jang, Hyerin Jung, Yoojun Nam, Yeri Alice Rim, Juryun Kim, Sang Hoon Jeong and Ji Hyeon Ju
    Citation: Stem Cell Research & Therapy 2016 7:184
    Content type: Research Published on:

  14. Tid1 is a mitochondrial co-chaperone protein and its transcript is abundantly expressed in skeletal muscle tissues. However, the physiological function of Tid1 during skeletal myogenesis remains unclear.

    Authors: Li-Hao Cheng, Kai-Feng Hung, Te-Chang Lee, Chih-Yang Huang, Wen-Ting Chiu, Jeng-Fan Lo and Tung-Fu Huang
    Citation: Stem Cell Research & Therapy 2016 7:185
    Content type: Research Published on:

  15. Nitric oxide (NO) plays a role in a number of physiological processes including stem cell differentiation and osteogenesis. Endothelial nitric oxide synthase (eNOS), one of three NO-producing enzymes, is locat...

    Authors: Nadeeka Bandara, Saliya Gurusinghe, Shiang Yong Lim, Haying Chen, Shuangfeng Chen, Dawei Wang, Bryan Hilbert, Le-Xin Wang and Padraig Strappe
    Citation: Stem Cell Research & Therapy 2016 7:182
    Content type: Research Published on:

  16. Although the unconjugated secondary bile acids, specifically deoxycholic acid (DCA) and lithocholic acid (LCA), are considered to be risk factors for colorectal cancer, the precise mechanism(s) by which they r...

    Authors: Lulu Farhana, Pratima Nangia-Makker, Evan Arbit, Kathren Shango, Sarah Sarkar, Hamidah Mahmud, Timothy Hadden, Yingjie Yu and Adhip P. N. Majumdar
    Citation: Stem Cell Research & Therapy 2016 7:181
    Content type: Research Published on:

  17. Colorectal cancer (CRC) is one of the most common malignancies in the world. microRNA-140-5p (miR-140) has been shown to be involved in cartilage development and osteoarthritis (OA) pathogenesis. Some contradi...

    Authors: Lihui Yu, Ying Lu, Xiaocui Han, Wenyue Zhao, Jiazhi Li, Jun Mao, Bo Wang, Jie Shen, Shujun Fan, Lu Wang, Mei Wang, Lianhong Li, Jianwu Tang and Bo Song
    Citation: Stem Cell Research & Therapy 2016 7:180
    Content type: Research Published on:

    The Retraction Note to this article has been published in Stem Cell Research & Therapy 2021 12:136

  18. Mesenchymal stem/multipotent stromal cells (MSCs) contribute to tissue repair but are challenged during wound healing when the blood supply is disrupted, thereby limiting nutrient delivery. Survival mechanisms...

    Authors: Austin Nuschke, Melanie Rodrigues, Albin W. Wells, Kyle Sylakowski and Alan Wells
    Citation: Stem Cell Research & Therapy 2016 7:179
    Content type: Short report Published on:

  19. This prospective clinical case series aimed to investigate the safety of subretinal adipose tissue-derived mesenchymal stem cell (ADMSC) implantation in advanced stage retinitis pigmentosa (RP).

    Authors: Ayse Oner, Z. Burcin Gonen, Neslihan Sinim, Mustafa Cetin and Yusuf Ozkul
    Citation: Stem Cell Research & Therapy 2016 7:178
    Content type: Research Published on:

  20. Complex immunophenotypic repertoires defining discrete adipose-derived stem cell (ASC) subpopulations may hold a key toward identifying predictors of clinical utility. To this end, we sorted out of the freshly...

    Authors: Frederik Mølgaard Nielsen, Simone Elkjær Riis, Jens Isak Andersen, Raphaëlle Lesage, Trine Fink, Cristian Pablo Pennisi and Vladimir Zachar
    Citation: Stem Cell Research & Therapy 2016 7:177
    Content type: Research Published on:

  21. Umbilical cord blood (UCB) not only contains hematopoietic stem cells (HSCs), but also non-hematopoietic stem cells (NHSCs) that are able to differentiate into a number of distinct cell types. Based on studies...

    Authors: Junjie Wu, Yun Sun, Travis J. Block, Milos Marinkovic, Zhi-Liang Zhang, Richard Chen, Yixia Yin, Juquan Song, David D. Dean, Zhongding Lu and Xiao-Dong Chen
    Citation: Stem Cell Research & Therapy 2016 7:176
    Content type: Research Published on:

  22. Epithelial to mesenchymal transition, especially to myofibroblasts, plays an important role in wound healing, fibrosis, and carcinogenesis. Epidermal stem cells (EpSCs) are responsible for epidermal renewal an...

    Authors: Haisheng Li, Zhihui Yao, Weifeng He, Hongyan Gao, Yang Bai, Sisi Yang, Lu Zhang, Rixing Zhan, Jianglin Tan, Junyi Zhou, Masao Takata, Jun Wu and Gaoxing Luo
    Citation: Stem Cell Research & Therapy 2016 7:175
    Content type: Research Published on:

  23. The epicardium, a cell layer covering the heart, plays an important role during cardiogenesis providing cardiovascular cell types and instructive signals, but becomes quiescent during adulthood. Upon cardiac i...

    Authors: Asja T. Moerkamp, Kirsten Lodder, Tessa van Herwaarden, Esther Dronkers, Calinda K. E. Dingenouts, Fredrik C. Tengström, Thomas J. van Brakel, Marie-José Goumans and Anke M. Smits
    Citation: Stem Cell Research & Therapy 2016 7:174
    Content type: Research Published on:

  24. Endothelial colony-forming cells (ECFCs), also termed late outgrowth endothelial cells, are a well-defined circulating endothelial progenitor cell type with an established role in vascular repair. ECFCs have c...

    Authors: Michelle B. Hookham, Imran H. A. Ali, Christina L. O’Neill, Emer Hackett, Melanie H. Lambe, Tina Schmidt, Reinhold J. Medina, Sara Chamney, Bharathi Rao, Eibhlin McLoone, David Sweet, Alan W. Stitt and Derek P. Brazil
    Citation: Stem Cell Research & Therapy 2016 7:173
    Content type: Research Published on:

  25. Cirrhosis is a major health problem worldwide and new therapies are needed. Hepatic macrophages (hMø) have a pivotal role in liver fibrosis, being able to act in both its promotion and its resolution. It is we...

    Authors: Esteban Fiore, Mariana Malvicini, Juan Bayo, Estanislao Peixoto, Catalina Atorrasagasti, Romina Sierra, Marcelo Rodríguez, Sofia Gómez Bustillo, Mariana G. García, Jorge B. Aquino and Guillermo Mazzolini
    Citation: Stem Cell Research & Therapy 2016 7:172
    Content type: Research Published on:

  26. The success of hematopoietic stem cell (HSC) transplantation is dependent on the quality of the donor HSCs. Some sources of HSCs display reduced engraftment efficiency either because of inadequate number (e.g....

    Authors: Sapana Jalnapurkar, Shweta Singh, Moirangthem Ranjita Devi, Lalita Limaye and Vaijayanti Kale
    Citation: Stem Cell Research & Therapy 2016 7:171
    Content type: Research Published on:

  27. We determined whether bone marrow mesenchymal stem cells (BMMSCs) transduced with heme oxygenase-1 (HO-1), a cytoprotective and immune-protective factor, could improve outcomes for small bowel transplantation ...

    Authors: Yang Yang, Hong Li Song, Wen Zhang, Ben Juan Wu, Nan Nan Fu, Chong Dong and Zhong Yang Shen
    Citation: Stem Cell Research & Therapy 2016 7:164
    Content type: Research Published on:

  28. Fanconi anemia (FA) is an autosomal-recessive disorder associated with hematopoietic failure and it is a candidate for hematopoietic stem cell (HSC)-directed gene therapy. However, the characteristically reduc...

    Authors: Santhosh Chakkaramakkil Verghese, Natalya A. Goloviznina and Peter Kurre
    Citation: Stem Cell Research & Therapy 2016 7:170
    Content type: Short report Published on:

  29. It is known that a paracrine mechanism exists between mesenchymal stem cells and target cells. This process may involve microvesicles (MVs) as an integral component of cell-to-cell communication.

    Authors: Claudia Perrini, Maria Giuseppina Strillacci, Alessandro Bagnato, Paola Esposti, Maria Giovanna Marini, Bruna Corradetti, Davide Bizzaro, Antonella Idda, Sergio Ledda, Emanuele Capra, Flavia Pizzi, Anna Lange-Consiglio and Fausto Cremonesi
    Citation: Stem Cell Research & Therapy 2016 7:169
    Content type: Research Published on:

  30. Pelvic floor dysfunction (PFD) is a condition affecting many women worldwide, with symptoms including stress urinary incontinence (SUI) and pelvic organ prolapse (POP). We have previously demonstrated stable e...

    Authors: Minfei Jin, Yuelin Wu, Jun Wang, Weiping Ye, Lei Wang, Peipei Yin, Wei Liu, Chenhao Pan and Xiaolin Hua
    Citation: Stem Cell Research & Therapy 2016 7:167
    Content type: Research Published on:

  31. Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) are gaining increasing interest as an alternative source of stem cells for regenerative medicine applications. Definitive endoderm (DE) specification is...

    Authors: Ashraf Al Madhoun, Hamad Ali, Sarah AlKandari, Valerie Lopez Atizado, Nadeem Akhter, Fahd Al-Mulla and Maher Atari
    Citation: Stem Cell Research & Therapy 2016 7:165
    Content type: Research Published on:

  32. Cellular reprogramming is a stressful process, which requires cells to engulf somatic features and produce and maintain stemness machineries. Autophagy is a process to degrade unwanted proteins and is required...

    Authors: Areechun Sotthibundhu, Katya McDonagh, Alexander von Kriegsheim, Amaya Garcia-Munoz, Agnieszka Klawiter, Kerry Thompson, Kapil Dev Chauhan, Janusz Krawczyk, Veronica McInerney, Peter Dockery, Michael J. Devine, Tilo Kunath, Frank Barry, Timothy O’Brien and Sanbing Shen
    Citation: Stem Cell Research & Therapy 2016 7:166
    Content type: Research Published on:

  33. Tissue-engineering strategies based on mesenchymal stem cells (MSCs) and cell sheets have been widely used for periodontal tissue regeneration. However, given the complexity in periodontal structure, the regen...

    Authors: Hao Zhang, Shiyu Liu, Bin Zhu, Qiu Xu, Yin Ding and Yan Jin
    Citation: Stem Cell Research & Therapy 2016 7:168
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:363

  34. Tissue-specific stem/progenitor cells are found in various adult tissues and may have the capacity for lineage-specific differentiation, facilitating applications in autologous transplantation. Stage-specific ...

    Authors: Song Lee, Chan Mi Lee and Song Cheol Kim
    Citation: Stem Cell Research & Therapy 2016 7:162
    Content type: Research Published on:

  35. Mesenchymal stem cells (MSCs) have been widely proven effective for therapeutic angiogenesis in ischemia animal models as well as clinical vascular diseases. Because of the invasive method, limited resources, ...

    Authors: Wen Jing Du, Ying Chi, Zhou Xin Yang, Zong Jin Li, Jun Jie Cui, Bao Quan Song, Xue Li, Shao Guang Yang, Zhi Bo Han and Zhong Chao Han
    Citation: Stem Cell Research & Therapy 2016 7:163
    Content type: Research Published on:

  36. Human adipose-derived mesenchymal stem cells (haMSCs) have shown efficacy in treating osteoarthritis (OA) both preclinically and clinically via intra-articular (IA) injection. However, understanding the mode o...

    Authors: Meng Li, Xuan Luo, Xiaoteng Lv, Victor Liu, Guangyu Zhao, Xue Zhang, Wei Cao, Richard Wang and Wen Wang
    Citation: Stem Cell Research & Therapy 2016 7:160
    Content type: Research Published on:

  38. The avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokin...

    Authors: Yan Li, Jun Xu, Weiqing Shi, Cheng Chen, Yan Shao, Limei Zhu, Wei Lu and XiaoDong Han
    Citation: Stem Cell Research & Therapy 2016 7:159
    Content type: Research Published on:

  39. Although endothelial progenitor cells (EPCs) contribute to wound repair by promoting neovascularization, the mechanism of EPC-mediated wound healing remains poorly understood due to the lack of pivotal molecul...

    Authors: Jun Hee Lee, Seung Taek Ji, Jaeho Kim, Satoshi Takaki, Takayuki Asahara, Young-Joon Hong and Sang-Mo Kwon
    Citation: Stem Cell Research & Therapy 2016 7:158
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2017 8:50

  40. Liver transplantation is the optimal treatment option for end-stage liver disease, but organ shortages dramatically restrict its application. Donation after cardiac death (DCD) is an alternative approach that ...

    Authors: Yang Tian, Jingcheng Wang, Wei Wang, Yuan Ding, Zhongquan Sun, Qiyi Zhang, Yan Wang, Haiyang Xie, Sheng Yan and Shusen Zheng
    Citation: Stem Cell Research & Therapy 2016 7:157
    Content type: Research Published on:

  41. Embryonic stem cell (ESC) derivatives hold great promise for the construction of tissue-engineered skin equivalents (TESE). However, harvesting of ESCs destroys viable embryos and may lead to political and eth...

    Authors: Yang Rao, Jihong Cui, Lu Yin, Wei Liu, Wenguang Liu, Mei Sun, Xingrong Yan, Ling Wang and Fulin Chen
    Citation: Stem Cell Research & Therapy 2016 7:156
    Content type: Research Published on:

  42. Diabetic foot ulcer (DFU) is an intractable diabetic complication. Patients suffering from diabetes mellitus (DM) frequently present with infected DFUs. In this study, a wound healing model on diabetic rat foo...

    Authors: Rongfeng Shi, Yinpeng Jin, Chuanwu Cao, Shilong Han, Xiaowen Shao, Lingyu Meng, Jie Cheng, Meiling Zhang, Jiayi Zheng, Jun Xu and Maoquan Li
    Citation: Stem Cell Research & Therapy 2016 7:155
    Content type: Research Published on:

  43. Lowering oxygen from atmospheric level (hyperoxia) to the physiological level (physioxia) of articular cartilage promotes mesenchymal stem cell (MSC) chondrogenesis. However, the literature is equivocal regard...

    Authors: Devon E. Anderson, Brandon D. Markway, Derek Bond, Helen E. McCarthy and Brian Johnstone
    Citation: Stem Cell Research & Therapy 2016 7:154
    Content type: Research Published on:

  44. Bone marrow-derived cell therapy has been used to treat acute myocardial infarction. However, the therapeutic efficacy of this approach remains controversial. Here, we performed a systematic review and meta-an...

    Authors: Seon Heui Lee, Jin Hyuk Hong, Kyoung Hee Cho, Jin-Won Noh and Hyun-Jai Cho
    Citation: Stem Cell Research & Therapy 2016 7:153
    Content type: Research Published on:

  46. Combined cell implantation has been widely applied in tissue engineering in recent years. In this meta-analysis, we aimed to establish whether the combined transplantation of mesenchymal stem cells (MSCs) and ...

    Authors: Kunming Sun, Zheng Zhou, Xinxin Ju, Yang Zhou, Jiaojiao Lan, Dongdong Chen, Hongzhi Chen, Manli Liu and Lijuan Pang
    Citation: Stem Cell Research & Therapy 2016 7:151
    Content type: Review Published on:

  47. Recently, it has been observed that mesenchymal stem cells (MSCs) can modulate their immunoregulatory properties depending on the specific in-vitro activation of different Toll-like receptors (TLR), such as TL...

    Authors: Ana María Vega-Letter, Mónica Kurte, Catalina Fernández-O’Ryan, Melanie Gauthier-Abeliuk, Patricia Fuenzalida, Ivón Moya-Uribe, Claudia Altamirano, Fernando Figueroa, Carlos Irarrázabal and Flavio Carrión
    Citation: Stem Cell Research & Therapy 2016 7:150
    Content type: Research Published on:

  48. Newcastle disease virus (NDV) is an avian paramyxovirus, which selectively exerts oncolytic effects in cancer cells. Mesenchymal stem cells (MSCs) have been reported to affect tumor growth and deliver anti-tum...

    Authors: Gila Kazimirsky, Wei Jiang, Shimon Slavin, Amotz Ziv-Av and Chaya Brodie
    Citation: Stem Cell Research & Therapy 2016 7:149
    Content type: Research Published on:

  49. The success of cochlear implantation may be further improved by minimizing implantation trauma. The physical trauma of implantation and subsequent immunological sequelae can affect residual hearing and the via...

    Authors: Ariane Roemer, Ulrike Köhl, Omid Majdani, Stephan Klöß, Christine Falk, Sabine Haumann, Thomas Lenarz, Andrej Kral and Athanasia Warnecke
    Citation: Stem Cell Research & Therapy 2016 7:148
    Content type: Research Published on:

  50. Bone marrow stromal cells (BMSCs) are attractive as a source of neural progenitors for ex vivo generation of neurons and glia. Limited numbers of this subpopulation, however, hinder translation into autologous...

    Authors: Kwan-Long Mung, Yat-Ping Tsui, Evelyn Wing-Yin Tai, Ying-Shing Chan, Daisy Kwok-Yan Shum and Graham Ka-Hon Shea
    Citation: Stem Cell Research & Therapy 2016 7:146
    Content type: Research Published on:
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