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  1. Limbal stem cells (LSCs) are crucial for the regeneration of the corneal epithelium in patients with limbal stem cell deficiency (LSCD). Thus, LSCs during cultivation in vitro should be in highly homogeneous a...

    Authors: Marija Zekušić, Marina Bujić Mihica, Marija Skoko, Kruno Vukušić, Patrik Risteski, Jelena Martinčić, Iva M. Tolić, Krešo Bendelja, Snježana Ramić, Tamara Dolenec, Ivana Vrgoč Zimić, Dominik Puljić, Ivanka Petric Vicković, Renata Iveković, Ivanka Batarilo, Uršula Prosenc Zmrzljak…
    Citation: Stem Cell Research & Therapy 2023 14:368
  2. Human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) hold great promise for cardiac disease modelling, drug discovery and regenerative medicine. Despite the advancement in various differentiation pr...

    Authors: Lee Chuen Liew, Boon Min Poh, Omer An, Beatrice Xuan Ho, Christina Ying Yan Lim, Jeremy Kah Sheng Pang, Leslie Y. Beh, Henry He Yang and Boon-Seng Soh
    Citation: Stem Cell Research & Therapy 2023 14:367
  3. Induced pluripotent stem cell (iPSC)-derived cell therapies are an interesting new area in the field of regenerative medicine. One of the approaches to decrease the costs of iPSC-derived therapies is the use o...

    Authors: B. Kuebler, B. Alvarez-Palomo, B. Aran, J. Castaño, L. Rodriguez, A. Raya, S. Querol Giner and A. Veiga
    Citation: Stem Cell Research & Therapy 2023 14:366
  4. The term sepsis refers to a complex and heterogeneous syndrome. Although great progress has been made in improving the diagnosis and treatment of this condition, it continues to have a huge impact on morbidity...

    Authors: J. F. Vélez-Pinto, M. Garcia-Arranz, D. García-Bernal, S. García Gómez-Heras, P. Villarejo-Campos, A. M. García-Hernández, L. Vega-Clemente, S. Jiménez-Galanes, H. Guadalajara, J. M. Moraleda and D. García-Olmo
    Citation: Stem Cell Research & Therapy 2023 14:365
  5. Human mesenchymal stem cells (hMSCs) utilize discrete biosynthetic pathways to self-renew and differentiate into specific cell lineages, with undifferentiated hMSCs harbouring reliance on glycolysis and hMSCs ...

    Authors: Nuno G. B. Neto, Meenakshi Suku, David A. Hoey and Michael G. Monaghan
    Citation: Stem Cell Research & Therapy 2023 14:364
  6. Despite a long history of investigation and sustained efforts in clinical testing, the number of market authorisations for mesenchymal stromal cell (MSC) therapies remains limited, with none approved by the Un...

    Authors: Joan C. Fitzgerald, Georgina Shaw, J. Mary Murphy and Frank Barry
    Citation: Stem Cell Research & Therapy 2023 14:363
  7. This 1-year open-label extension study aimed to identify the persistent synergistic effects of allogeneic umbilical cord blood (UCB) cells and erythropoietin (EPO) in children with cerebral palsy (CP) for up t...

    Authors: Mi Ri Suh, Kyunghoon Min, Kye Hee Cho, Jongwook Kim, Ikhyun Lim, Mijin Park, Eun-Min Noh and Min Young Kim
    Citation: Stem Cell Research & Therapy 2023 14:362
  8. The ongoing coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on our societies. Moreover, the disease’s extensive and sustained symptoms are now becoming a nonnegligible medical challenge...

    Authors: Xiao Li, Hengrui Hu, Wanlin Liu, Qiyu Zhang, Yujie Wang, Xingjuan Chen, Yunping Zhu, Zhihong Hu, Manli Wang, Jie Ma and Ling Leng
    Citation: Stem Cell Research & Therapy 2023 14:361
  9. Safety evaluations in preclinical studies are needed to confirm before translating a cell-based product into clinical application. We previously developed a serum-free, xeno-free, and chemically defined media ...

    Authors: Xiaoyun Wu, Zhijie Ma, Yuxiao Yang, Yongxu Mu and Daocheng Wu
    Citation: Stem Cell Research & Therapy 2023 14:360
  10. Hepatic osteodystrophy (HOD) is a metabolically associated bone disease mainly manifested as osteoporosis with the characteristic of bone loss induced by chronic liver disease (CLD). Due to its high incidence ...

    Authors: Senzhe Xia, Xueqian Qin, Jinglin Wang and Haozhen Ren
    Citation: Stem Cell Research & Therapy 2023 14:359
  11. Increasing evidence suggests that multipotent mesenchymal stem/stromal cells (MSCs) are a promising intervention strategy in treating autoimmune inflammatory diseases. It should be stated that systemic immunor...

    Authors: Akram Hoseinzadeh, Mahmoud Mahmoudi, Houshang Rafatpanah, Zahra Rezaieyazdi, Jalil Tavakol Afshari, Sara Hosseini and Seyed-Alireza Esmaeili
    Citation: Stem Cell Research & Therapy 2023 14:358
  12. Cardiac remodeling is the initiating factor for the development of heart failure, which can result from various cardiomyopathies. Cytochrome c oxidase subunit 6A2 (COX6A2) is one of the components of cytochrom...

    Authors: Mengqi Jiang, Yuanxiu Song, Xi Chen, Wenjing Lu, Min Zhu, Mingyu Wei, Feng Lan, Ming Cui and Yun Bai
    Citation: Stem Cell Research & Therapy 2023 14:357
  13. Breast cancer (BC) is one of the diseases with the highest female mortality rates in the world and is closely related to breast cancer stem cells (BCSCs). Conventional breast cancer chemotherapy drugs target n...

    Authors: Xinyu Lin, Ying Wang, Kai Fang, Zijian Guo, Nan Lin and Lihua Li
    Citation: Stem Cell Research & Therapy 2023 14:356
  14. Urine-derived stem cells (UDSCs) can be easily isolated from urine and possess excellent stem cell characteristics, making them a promising source for cell therapeutics. Due to their kidney origin specificity,...

    Authors: Sang-Heon Kim, Sung-Hoon Lee, Jeong-Ah Jin, Hyung-Joon So, Jae-Ung Lee, Min-Jae Ji, Eun-Joong Kwon, Pyo-Sung Han, Hong-Ki Lee and Tae-Wook Kang
    Citation: Stem Cell Research & Therapy 2023 14:355
  15. Ventral midbrain (VM) dopaminergic progenitor cells derived from human pluripotent stem cells have the potential to replace endogenously lost dopamine neurons and are currently in preclinical and clinical deve...

    Authors: Pedro Rifes, Marc Isaksson, Charlotte Rusimbi, Adrián Ramón Santonja, Jenny Nelander, Thomas Laurell and Agnete Kirkeby
    Citation: Stem Cell Research & Therapy 2023 14:354
  16. Ischemia/reperfusion injury is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to ...

    Authors: João Faria, Sandra Calcat-i-Cervera, Renata Skovronova, Bonnie C. Broeksma, Alinda J. Berends, Esther A. Zaal, Benedetta Bussolati, Timothy O’Brien, Silvia M. Mihăilă and Rosalinde Masereeuw
    Citation: Stem Cell Research & Therapy 2023 14:353
  17. Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) sheets have recently attracted attention as an alternative approach to injected cell suspensions for stem cell therapy. However, cell engraftment an...

    Authors: Mitsuyoshi Nakao, Makoto Matsui, Kyungsook Kim, Nobuhiro Nishiyama, David W. Grainger, Teruo Okano, Hideko Kanazawa and Kenichi Nagase
    Citation: Stem Cell Research & Therapy 2023 14:352
  18. Kupffer cells (KCs) originate from yolk-sac progenitors before birth. Throughout adulthood, they self-maintain independently from the input of circulating monocytes (MOs) at a steady state and are replenished ...

    Authors: Xu Fan, Pei Lu, Xiang-Hua Cui, Peng Wu, Wei-Ran Lin, Dong Zhang, Shong-Zong Yuan, Bing Liu, Fang-Yan Chen, Hong You, Han-Dong Wei, Fu-Chu He, Ji-Dong Jia and Ying Jiang
    Citation: Stem Cell Research & Therapy 2023 14:351
  19. The objective of this study was to identify potential biomarkers for predicting response to MSC therapy by pre-MSC treatment plasma proteomic profile in severe COVID-19 in order to optimize treatment choice.

    Authors: Tian-Tian Li, Wei-Qi Yao, Hai-Bo Dong, Ze-Rui Wang, Zi-Ying Zhang, Meng-Qi Yuan, Lei Shi and Fu-Sheng Wang
    Citation: Stem Cell Research & Therapy 2023 14:350
  20. Various methods for ex utero culture systems have been explored. However, limitations remain regarding the in vitro culture platforms used before implanting mouse embryos and the normal development of mouse bl...

    Authors: Junjun Xu, Linye Zhang, Zihui Ye, Binwen Chang, Zheng Tu, Xuguang Du, Xi Wen and Yili Teng
    Citation: Stem Cell Research & Therapy 2023 14:349
  21. Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is a fatal neurodegenerative disease with currently no treatment options. Stem cell therapy for neurodegenerative diseases is eme...

    Authors: Katie Williams, Simote T. Foliaki, Brent Race, Anna Smith, Tina Thomas, Bradley R. Groveman and Cathryn L. Haigh
    Citation: Stem Cell Research & Therapy 2023 14:348
  22. Mesenchymal stromal cells (MSCs) show considerable promise in regenerative medicine with superior anti-fibrotic, immunomodulatory, and angiogenic functions. More recently, discovered with the tumor tropism, MS...

    Authors: Yizuo Song, Hejing Liu, Shuya Pan, Xinli Xiang, Miaomiao Ye and Xueqiong Zhu
    Citation: Stem Cell Research & Therapy 2023 14:347
  23. The CRX-associated autosomal dominant retinopathies suggest a possible pathogenic mechanism of gene haploinsufficiency. However, based on reported human patient cases and studies with mouse models, it is hard to ...

    Authors: Deng Pan, Xiao Zhang, Kangxin Jin and Zi-Bing Jin
    Citation: Stem Cell Research & Therapy 2023 14:346
  24. Genomic sequencing in congenital heart disease (CHD) patients often discovers novel genetic variants, which are classified as variants of uncertain significance (VUS). Functional analysis of each VUS is requir...

    Authors: Vanessa S. Fear, Catherine A. Forbes, Nicole C. Shaw, Kathryn O. Farley, Jessica L. Mantegna, Jasmin P. Htun, Genevieve Syn, Helena Viola, Henrietta Cserne Szappanos, Livia Hool, Michelle Ward, Gareth Baynam and Timo Lassmann
    Citation: Stem Cell Research & Therapy 2023 14:345
  25. Mesenchymal stromal cells (MSCs) have regenerative and immunomodulatory properties, making them suitable for cell therapy. Toll-like receptors (TLRs) in MSCs respond to viral load by secreting immunosuppressiv...

    Authors: Tatiana Tolstova, Ekaterina Dotsenko, Peter Kozhin, Svetlana Novikova, Victor Zgoda, Alexander Rusanov and Nataliya Luzgina
    Citation: Stem Cell Research & Therapy 2023 14:344
  26. The Wnt signaling pathway has been implicated in the pathogenesis of fibrotic disorders and malignancies. Hence, we aimed to assess the potential of the induced pluripotent stem cells (IPS) in modulating the e...

    Authors: Paria Bayati, Marjan Taherian, Mansoureh Soleimani, Hamid Farajifard and Nazanin Mojtabavi
    Citation: Stem Cell Research & Therapy 2023 14:343
  27. Epithelial–mesenchymal transition (EMT) is a cell remodeling process in which epithelial cells undergo a reversible phenotype switch via the loss of adhesion capacity and acquisition of mesenchymal characteris...

    Authors: Raheleh Farahzadi, Behnaz Valipour, Ezzatollah Fathi, Samaneh Pirmoradi, Ommoleila Molavi, Soheila Montazersaheb and Zohreh Sanaat
    Citation: Stem Cell Research & Therapy 2023 14:342
  28. The functional impairment of adipose stem cells (ASCs) during aging limits their clinical transformation. Studies have shown that extrachromosomal circular DNAs (eccDNAs) are associated with tumor progression ...

    Authors: Sen Ren, Du Wu, Xiaoyong Shen, Qian Wu, Chengcheng Li, Hewei Xiong, Zhongwei Xiong, Rui Gong, Zheng Liu, Wei Wang and Jincao Chen
    Citation: Stem Cell Research & Therapy 2023 14:341
  29. Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration and impose a considerable economic burden on patients and society, making efforts to cure blindness imperative. Transg...

    Authors: Yuqin Liang, Xihao Sun, Chunwen Duan, Shibo Tang and Jiansu Chen
    Citation: Stem Cell Research & Therapy 2023 14:340
  30. The secretome of mesenchymal stromal cells isolated from the amniotic membrane (hAMSCs) has been extensively studied for its in vitro immunomodulatory activity as well as for the treatment of several preclinic...

    Authors: Alexandra Muntiu, Andrea Papait, Federica Vincenzoni, Alberto Vitali, Wanda Lattanzi, Pietro Romele, Anna Cargnoni, Antonietta Silini, Ornella Parolini and Claudia Desiderio
    Citation: Stem Cell Research & Therapy 2023 14:339
  31. Contrast-induced nephropathy (CIN) is a major clinical problem associated with acute kidney injury during hospitalization. However, effective treatments for CIN are currently lacking. Mesenchymal stem cells (M...

    Authors: Mitsuki Kadono, Ayumu Nakashima, Naoki Ishiuchi, Kensuke Sasaki, Yoshie Miura, Satoshi Maeda, Asuka Fujita, Ayano Sasaki, Shogo Nagamatsu and Takao Masaki
    Citation: Stem Cell Research & Therapy 2023 14:337
  32. Kidney organoids derived from human pluripotent stem cells (HiPSCs) hold huge applications for drug screening, disease modeling, and cell transplanting therapy. However, these applications are limited since ki...

    Authors: Kexin Peng, Wanqin Xie, Tingting Wang, Yamei Li, Jean de Dieu Habimana, Obed Boadi Amissah, Jufang Huang, Yong Chen, Bin Ni and Zhiyuan Li
    Citation: Stem Cell Research & Therapy 2023 14:336
  33. The metabolic reprogramming of mesenchymal stem/stromal cells (MSC) favoring glycolysis has recently emerged as a new approach to improve their immunotherapeutic abilities. This strategy is associated with gre...

    Authors: Carolina Pradenas, Noymar Luque-Campos, Karina Oyarce, Rafael Contreras-Lopez, Felipe A. Bustamante-Barrientos, Andrés Bustos, Felipe Galvez-Jiron, María Jesús Araya, Catalina Asencio, Raúl Lagos, Yeimi Herrera-Luna, Daouda Abba Moussa, Charlotte Nicole Hill, Eliana Lara-Barba, Claudia Altamirano, Alexander Ortloff…
    Citation: Stem Cell Research & Therapy 2023 14:335
  34. Mesenchymal stem cells (MSCs) are adult stem cells with self-renewal and multi-directional differentiation potential and possess the functions of immunomodulation, regulation of cell growth, and repair of dama...

    Authors: Jingfang Xiao, Xiaoyuan Gong, Zhenlan Fu, Xiongbo Song, Qinghua Ma, Jingya Miao, Ruili Cai, Zexuan Yan, Shuai Wang, Qian Li, Yaokai Chen, Liu Yang, Xiuwu Bian and Yemiao Chen
    Citation: Stem Cell Research & Therapy 2023 14:334
  35. Assisted reproduction faces a significant obstacle in the form of poor ovarian response (POR) to controlled ovarian stimulation. To address this challenge, mesenchymal stem cell therapy has been proposed as a ...

    Authors: Simin Zafardoust, Somaieh Kazemnejad, Mina Fathi-Kazerooni, Maryam Darzi, Mohammad Reza Sadeghi, Ali Sadeghi Tabar and Zahra Sehat
    Citation: Stem Cell Research & Therapy 2023 14:332
  36. Acute compartment syndrome (ACS) is one of the most common complications of musculoskeletal injury, leading to the necrosis and demise of skeletal muscle cells. Our previous study showed that embryonic stem ce...

    Authors: Xiangkang Jiang, Jingyuan Yang, Yao Lin, Fei Liu, Jiawei Tao, Wenbin Zhang, Jiefeng Xu and Mao Zhang
    Citation: Stem Cell Research & Therapy 2023 14:331
  37. A non-invasive imaging technology that can monitor cell viability, retention, distribution, and interaction with host tissue after transplantation is needed for optimizing and translating stem cell-based thera...

    Authors: Keyu Zhuang, Rocco Romagnuolo, Tamilla Sadikov Valdman, Kyle D. W. Vollett, Daniel A. Szulc, Hai-Ying Mary Cheng, Michael A. Laflamme and Hai-Ling Margaret Cheng
    Citation: Stem Cell Research & Therapy 2023 14:330
  38. Mesenchymal stem cells (MSCs) have immunomodulatory properties and therapeutic effects on autoimmune diseases through their secreted factors, referred to as the secretome. However, the specific key factors of ...

    Authors: Eunhee Ko, Taejun Yoon, Yoojin Lee, Jongsun Kim and Yong-Beom Park
    Citation: Stem Cell Research & Therapy 2023 14:329
  39. Mesenchymal stem cells (MSCs) have shown promising potential in allograft survival. However, few reports have focused on comparing the immunosuppressive capacity of MSCs from different sources and administered...

    Authors: Huanmin Kang, Jianing Feng, Yingqian Peng, Yingyi Liu, Yalei Yang, Ying Wu, Jian Huang, Ying Jie, Baihua Chen and Yan He
    Citation: Stem Cell Research & Therapy 2023 14:328
  40. Chemotherapy can cause ovarian dysfunction and infertility since the ovary is extremely sensitive to chemotherapeutic drugs. Apart from the indispensable role of the ovary in the overall hormonal milieu, ovari...

    Authors: Shenghui Zhang, Badrul Hisham Yahaya, Ying Pan, Yanli Liu and Juntang Lin
    Citation: Stem Cell Research & Therapy 2023 14:327
  41. In regenerative medicine, especially skin tissue engineering, the focus is on enhancing the quality of wound healing. Also, several constructs with different regeneration potentials have been used for skin tis...

    Authors: Maryam Ghahremani-nasab, Naeimeh Akbari‑Gharalari, Azizeh Rahmani Del Bakhshayesh, Armita Ghotaslou, Abbas Ebrahimi-kalan, Mahdi Mahdipour and Ahmad Mehdipour
    Citation: Stem Cell Research & Therapy 2023 14:326
  42. Stromal vascular fraction (SVF) treatment promoted the regeneration of the intestinal epithelium, limiting lethality in a mouse model of radiation-induced gastrointestinal syndrome (GIS). The SVF has a heterog...

    Authors: Lydia Bensemmane, Fabien Milliat, Xavier Treton and Christine Linard
    Citation: Stem Cell Research & Therapy 2023 14:325
  43. Diabetes mellitus (DM) constitutes a chronic metabolic disease characterized by elevated levels of blood glucose which can also lead to the so-called diabetic vascular complications (DVCs), responsible for mos...

    Authors: Josefa Benítez-Camacho, Antonio Ballesteros, Lucía Beltrán-Camacho, Marta Rojas-Torres, Antonio Rosal-Vela, Margarita Jimenez-Palomares, Ismael Sanchez-Gomar and Mª Carmen Durán-Ruiz
    Citation: Stem Cell Research & Therapy 2023 14:324
  44. Cardiac pathological outcome of metabolic remodeling is difficult to model using cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC-CMs) due to low metabolic maturation.

    Authors: Dong Li, Lawrence C. Armand, Fangxu Sun, Hyun Hwang, David Wolfson, Antonio Rampoldi, Rui Liu, Parvin Forghani, Xin Hu, Wen-Mei Yu, Cheng-Kui Qu, Dean P. Jones, Ronghu Wu, Hee Cheol Cho, Joshua T. Maxwell and Chunhui Xu
    Citation: Stem Cell Research & Therapy 2023 14:322
  45. Macrophage polarization has been observed in the process of muscle injuries including rotator cuff (RC) muscle atrophy and fatty infiltration after large tendon tears. In our previous study, we showed that fib...

    Authors: Mengyao Liu, Martin Ng, Tuan Phu, Laura Bouchareychas, Brian T. Feeley, Hubert T. Kim, Robert L. Raffai and Xuhui Liu
    Citation: Stem Cell Research & Therapy 2023 14:321
  46. Human mitochondrial DNA mutations are associated with common to rare mitochondrial disorders, which are multisystemic with complex clinical pathologies. The pathologies of these diseases are poorly understood ...

    Authors: Fibi Meshrkey, Kelly M. Scheulin, Christopher M. Littlejohn, Joshua Stabach, Bibhuti Saikia, Vedant Thorat, Yimin Huang, Thomas LaFramboise, Edward J. Lesnefsky, Raj R. Rao, Franklin D. West and Shilpa Iyer
    Citation: Stem Cell Research & Therapy 2023 14:320
  47. Ever since their discovery, induced pluripotent stem cells (iPSCs) have been extensively differentiated into a large variety of cell types. However, a limited amount of work has been dedicated to differentiati...

    Authors: Alexander Blümke, Erica Ijeoma, Jessica Simon, Rachel Wellington, Medania Purwaningrum, Sergei Doulatov, Elizabeth Leber, Marta Scatena and Cecilia M. Giachelli
    Citation: Stem Cell Research & Therapy 2023 14:319

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