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  1. NANOG functions as the gateway for the generation of pluripotent stem cells (PSCs) in mice and humans. NANOG is a transcription factor highly expressed in pig pre-implantation embryos, indicating that it is a con...

    Authors: Junjun Xu, Zheng Zheng, Xuguang Du, Bingbo Shi, Jichang Wang, Dengfeng Gao, Qianqian Zhu, Xinze Chen and Jianyong Han

    Citation: Stem Cell Research & Therapy 2020 11:67

    Content type: Research

    Published on:

  2. The process of bone repair is heavily dependent on the ability of human bone marrow mesenchymal stem cells (hMSCs) to undergo osteogenic differentiation. MicroRNAs have been shown to regulate this osteogenic p...

    Authors: Tao Wang, Chao Zhang, Cihu Wu, Jianyun Liu, Hui Yu, Xiaoou Zhou, Jie Zhang, Xinping Wang, Shan He, Xiaoyuan Xu, Baicheng Ma, Xiangxin Che and Weidong Li

    Citation: Stem Cell Research & Therapy 2020 11:62

    Content type: Research

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  3. The homeostasis of oral pathogenic bacteria and probiotics plays a crucial role in maintaining the well-being and healthy status of human host. Our previous study confirmed that imbalanced oral microbiota coul...

    Authors: Nannan Han, Lu Jia, Lijia Guo, Yingying Su, Zhenhua Luo, Juan Du, Shenghui Mei and Yi Liu

    Citation: Stem Cell Research & Therapy 2020 11:61

    Content type: Research

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  4. Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. COPD results from chronic inflammation of the lungs. Current treatments, including physical and chemical therapies, p...

    Authors: Phuong Le Thi Bich, Ha Nguyen Thi, Hoang Dang Ngo Chau, Tien Phan Van, Quyet Do, Hung Dong Khac, Dong Le Van, Luc Nguyen Huy, Khan Mai Cong, Thang Ta Ba, Trung Do Minh, Ngoc Vu Bich, Nhat Truong Chau and Phuc Van Pham

    Citation: Stem Cell Research & Therapy 2020 11:60

    Content type: Research

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  5. Longitudinal studies have verified the pivotal role of mesenchymal stem/stromal cells (MSCs) in the bone marrow microenvironment for hematopoiesis and coordinate contribution to leukemia pathogenesis. However,...

    Authors: Jiali Huo, Leisheng Zhang, Xiang Ren, Chengwen Li, Xingxin Li, Peiyuan Dong, Xuan Zheng, Jinbo Huang, Yingqi Shao, Meili Ge, Jing Zhang, Min Wang, Neng Nie, Peng Jin and Yizhou Zheng

    Citation: Stem Cell Research & Therapy 2020 11:59

    Content type: Research

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  6. Skeletal unloading can induce severe disuse osteopenia that often occurs in spaceflight astronauts or in patients subjected to prolonged bed-rest or immobility. Previously, we revealed a mechano-sensitive fact...

    Authors: Zebing Hu, Lijun Zhang, Han Wang, Yixuan Wang, Yingjun Tan, Lei Dang, Ke Wang, Zhongyang Sun, Gaozhi Li, Xinsheng Cao, Shu Zhang, Fei Shi and Ge Zhang

    Citation: Stem Cell Research & Therapy 2020 11:58

    Content type: Research

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  7. The mechanisms by which macrophage phenotype contributes to mesenchymal stem cells (MSC)-mediated bone repair remain unclear. In this work, we investigated the influence of factors released by human macrophage...

    Authors: Gema Vallés, Fátima Bensiamar, Leila Maestro-Paramio, Eduardo García-Rey, Nuria Vilaboa and Laura Saldaña

    Citation: Stem Cell Research & Therapy 2020 11:57

    Content type: Research

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  8. Wound healing is a complex pathophysiological process that involves a variety of cells and cytokines. In this study, we found that local injection of human amnion mesenchymal stem cells into wounds in rats cou...

    Authors: Shaoying Gao, Tao Chen, Yi Hao, Feifei Zhang, Xiujun Tang, Dali Wang, Zairong Wei and Jianping Qi

    Citation: Stem Cell Research & Therapy 2020 11:56

    Content type: Research

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  9. In a number of disease processes, the body is unable to repair injured tissue, promoting the need to develop strategies for tissue repair and regeneration, including the use of cellular therapeutics. Trophobla...

    Authors: Minmin Hou, Junwen Han, Gu Li, Min-Young Kwon, Jiani Jiang, Sirisha Emani, Elizabeth S. Taglauer, Jin-Ah Park, Eun-Bee Choi, Munender Vodnala, Yick W. Fong, Sitaram M. Emani, Ivan O. Rosas, Mark A. Perrella and Xiaoli Liu

    Citation: Stem Cell Research & Therapy 2020 11:55

    Content type: Research

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  10. Due to the prominent role of the liver in the body and detoxification, its functionality can be affected in an irreversible manner by diseases. This phenomenon renders the liver to stop working, leading to mor...

    Authors: Afsoon Afshari, Sara Shamdani, Georges Uzan, Sina Naserian and Negar Azarpira

    Citation: Stem Cell Research & Therapy 2020 11:54

    Content type: Review

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  11. The simultaneous contribution of several etiopathogenic disturbances makes amyotrophic lateral sclerosis (ALS) a fatal and challenging disease. Here, we studied two different cell therapy protocols to protect ...

    Authors: Anna Martínez-Muriana, Diego Pastor, Renzo Mancuso, Amaya Rando, Rosario Osta, Salvador Martínez, Rubèn López-Vales and Xavier Navarro

    Citation: Stem Cell Research & Therapy 2020 11:53

    Content type: Research

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  12. Antibody production after allogeneic administration of mesenchymal stem cells (MSCs) could impact their clinical application. Proinflammatory priming of MSCs can potentiate their regulatory ability in vivo but...

    Authors: Laura Barrachina, Alina Cequier, Antonio Romero, Arantza Vitoria, Pilar Zaragoza, Francisco José Vázquez and Clementina Rodellar

    Citation: Stem Cell Research & Therapy 2020 11:52

    Content type: Research

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  13. Mesenchymal stem cell (MSC) transplantation is a fast-developing therapy in regenerative medicine. However, some concerns have been raised regarding their safety and the infusion-related pro-coagulant activity...

    Authors: Louise C. F. Coppin, Françoise Smets, Jérome Ambroise, Etienne E. M. Sokal and Xavier Stéphenne

    Citation: Stem Cell Research & Therapy 2020 11:51

    Content type: Research

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  14. Tissue expansion techniques play an important role in plastic surgery. How to improve the quality of the expanded skin and shorten the expansion period are still worth investigating. Our previous studies found...

    Authors: Mingwu Deng, Xiangsheng Wang, Ziyou Yu, Yizuo Cai, Wei Liu, Guangdong Zhou, Xiansong Wang, Zheyuan Yu, Wei Li and Wen Jie Zhang

    Citation: Stem Cell Research & Therapy 2020 11:50

    Content type: Research

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  15. Umbilical cord-derived mesenchymal stem cell (UCMSCs) transplantation has been widely studied in premature ovarian failure (POF). However, the underlying mechanism remains elusive. This study aims to investiga...

    Authors: Na Yin, Chenting Wu, Jianping Qiu, Yueming Zhang, Le Bo, Ying Xu, Mengdie Shi, Songyue Zhu, Guangzhao Yang and Caiping Mao

    Citation: Stem Cell Research & Therapy 2020 11:49

    Content type: Research

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  16. Lupus nephritis is usually manifested by proteinuria, active urinary sediment, hypertension, and renal failure and is a serious complication with more than 50% occurrence in systemic lupus erythematosus patien...

    Authors: Tianbiao Zhou, Chunling Liao, Hong-Yan Li, Wenshan Lin, Shujun Lin and Hongzhen Zhong

    Citation: Stem Cell Research & Therapy 2020 11:48

    Content type: Research

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  17. Despite increasing demand, current protocols for human pluripotent stem cell (hPSC)-derived retinal pigment epithelium (RPE) remain time, labor, and cost intensive. Additionally, absence of robust methods for ...

    Authors: Fabio Michelet, Aishwarya Balasankar, Nickolas Teo, Lawrence W. Stanton and Shweta Singhal

    Citation: Stem Cell Research & Therapy 2020 11:47

    Content type: Research

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  18. The mesenchymal stem cell (MSC) secretome, via the combined actions of its plethora of biologically active factors, is capable of orchestrating the regenerative responses of numerous tissues by both eliciting ...

    Authors: Dinesh Parate, Nurul Dinah Kadir, Cenk Celik, Eng Hin Lee, James H. P. Hui, Alfredo Franco-Obregón and Zheng Yang

    Citation: Stem Cell Research & Therapy 2020 11:46

    Content type: Research

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  19. Mesenchymal stromal cell (MSC) stemness capacity diminishes over prolonged in vitro culture, which negatively affects their application in regenerative medicine. To slow down the senescence of MSCs, here, we h...

    Authors: Mohammadhossein Khorraminejad-Shirazi, Mahsa Sani, Tahereh Talaei-Khozani, Mohammadreza Dorvash, Malihe Mirzaei, Mohammad Ali Faghihi, Ahmad Monabati and Armin Attar

    Citation: Stem Cell Research & Therapy 2020 11:45

    Content type: Research

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  20. Sepsis is a global inflammatory disease that causes death. It has been reported that mesenchymal stem cell (MSC) treatment can attenuate inflammatory and septic symptoms. In this study, we investigated how int...

    Authors: Sung Yong Ahn, Yong-Sun Maeng, Yu Rim Kim, Young Ho Choe, Han Sung Hwang and Young-Min Hyun

    Citation: Stem Cell Research & Therapy 2020 11:44

    Content type: Research

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  21. Cerebral palsy (CP) is a syndrome of childhood movement and posture disorders. Clinical evidence is still limited and sometimes inconclusive about the benefits of human umbilical cord mesenchymal stem cells (h...

    Authors: Jiaowei Gu, Li Huang, Che Zhang, Yong Wang, Ruibo Zhang, Ziliang Tu, Hengdong Wang, Xihui Zhou, Zhousheng Xiao, Zegan Liu, Xiang Hu, Zunchen Ke, Dabin Wang and Li Liu

    Citation: Stem Cell Research & Therapy 2020 11:43

    Content type: Research

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  22. Evidence has demonstrated conditioned medium (CM) from periodontal ligament stem cells (PDLSCs) improved periodontal regeneration. Gingival mesenchymal stem cells (GMSCs) have been considered an alternative st...

    Authors: Jiling Qiu, Xiaotong Wang, Haowen Zhou, Chunshu Zhang, Yijia Wang, Jiahui Huang, Meng Liu, Pishan Yang and Aimei Song

    Citation: Stem Cell Research & Therapy 2020 11:42

    Content type: Research

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  24. Alveolar bone loss is a frequent occurrence. Dental pulp stem cells (DPSCs) which have invasive accessibility and high osteogenic potential is a promising source for cell-based bone regeneration. EphrinB2 is i...

    Authors: Wen Wang, Changyong Yuan, Tengyu Geng, Yi Liu, Shaoyue Zhu, Chengfei Zhang, Zongxiang Liu and Penglai Wang

    Citation: Stem Cell Research & Therapy 2020 11:40

    Content type: Research

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  25. Chronic nonhealing wounds represent one of the most common complications of diabetes and require advanced treatment strategies. Increasing evidence supports the important role of mesenchymal stem cells in diab...

    Authors: Shichang Zhang, Li Chen, Guoying Zhang and Bo Zhang

    Citation: Stem Cell Research & Therapy 2020 11:39

    Content type: Research

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  26. As important players in cell-to-cell communication, exosomes (exo) are believed to play a similar role in promoting fracture healing. This study investigated whether exosomes derived from bone marrow mesenchym...

    Authors: Lu Zhang, Guangjun Jiao, Shanwu Ren, Xiaoqian Zhang, Ci Li, Wenliang Wu, Hongliang Wang, Haichun Liu, Hongming Zhou and Yunzhen Chen

    Citation: Stem Cell Research & Therapy 2020 11:38

    Content type: Research

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  27. Using a toxin-induced nonhuman primate model of acute liver failure (ALF), we previously reported that peripheral infusion of human umbilical cord mesenchymal stem cells (hUC-MSCs) strongly suppresses the acti...

    Authors: Mingyang Shao, Qing Xu, Zhenru Wu, Yuwei Chen, Yuke Shu, Xiaoyue Cao, Menglin Chen, Bo Zhang, Yongjie Zhou, Rong Yao, Yujun Shi and Hong Bu

    Citation: Stem Cell Research & Therapy 2020 11:37

    Content type: Research

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  28. A growing body of evidence suggests that stem cell-derived exosomal microRNAs (miRNAs) could be a promising cardioprotective therapy in the context of hypoxic conditions. The present study aims to explore how ...

    Authors: Zhuzhi Wen, Zun Mai, Xiaolin Zhu, Tao Wu, Yangxin Chen, Dengfeng Geng and Jingfeng Wang

    Citation: Stem Cell Research & Therapy 2020 11:36

    Content type: Research

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  29. Adipose-derived stem cell (ASC) expansion under atmospheric oxygen levels (21%) was previously shown to cause increased reactive oxygen species (ROS) accumulation and genetic instability compared to cells cult...

    Authors: Gal Tirza, Inna Solodeev, Meirav Sela, Ilanit Greenberg, Metsada Pasmanik-Chor, Eyal Gur and Nir Shani

    Citation: Stem Cell Research & Therapy 2020 11:35

    Content type: Research

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  30. Vascularization is important for the clinical application of tissue engineered products. Both adipose-derived stem cells (ASCs) and surgical prefabrication can be used to induce angiogenesis in scaffolds. Our ...

    Authors: Tomasz Dębski, Agata Kurzyk, Barbara Ostrowska, Juliusz Wysocki, Jakub Jaroszewicz, Wojciech Święszkowski and Zygmunt Pojda

    Citation: Stem Cell Research & Therapy 2020 11:34

    Content type: Research

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  31. The original article [1] contains an error in Fig. 5 whereby sub-Fig. 5c, d & 5e are mistakenly mixed-up.

    Authors: Rui Zuo, Minghan Liu, Yanqiu Wang, Jie Li, Wenkai Wang, Junlong Wu, Chao Sun, Bin Li, Ziwen Wang, Weiren Lan, Chao Zhang, Chunmeng Shi and Yue Zhou

    Citation: Stem Cell Research & Therapy 2020 11:33

    Content type: Correction

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    The original article was published in Stem Cell Research & Therapy 2019 10:30

  32. Mesenchymal stem cells (MSCs) hold great potential as a therapy for stroke and have previously been shown to promote recovery in preclinical models of cerebral ischaemia. MSCs secrete a wide range of growth fa...

    Authors: Catriona J. Cunningham, Raymond Wong, Jack Barrington, Sabrina Tamburrano, Emmanuel Pinteaux and Stuart M. Allan

    Citation: Stem Cell Research & Therapy 2020 11:32

    Content type: Research

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  33. Extracellular vesicles, especially exosomes, have emerged as key mediators of intercellular communication with the potential to improve cardiac function as part of cell-based therapies. We previously demonstra...

    Authors: Hanbin Chen, Wenzheng Xia and Meng Hou

    Citation: Stem Cell Research & Therapy 2020 11:31

    Content type: Research

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  34. Preeclampsia is a common obstetric syndrome affecting women in their first pregnancy and characterized by hypertension and proteinuria, which appears after 20 weeks of gestation. It is characterized by high bl...

    Authors: Yasser S. Basmaeil, Dana Algudiri, Reem Alenzi, Abdullah Al Subayyil, Ayodele Alaiya and Tanvir Khatlani

    Citation: Stem Cell Research & Therapy 2020 11:30

    Content type: Research

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  35. Mesenchymal stem cells (MSCs) secrete a cocktail of growth factors and cytokines, which could promote tissue regeneration and wound healing. Therefore, in clinical practice, post-culture MSC supernatant treatm...

    Authors: Honorata Kraskiewicz, Maria Paprocka, Aleksandra Bielawska-Pohl, Agnieszka Krawczenko, Kinga Panek, Judyta Kaczyńska, Agnieszka Szyposzyńska, Mateusz Psurski, Piotr Kuropka and Aleksandra Klimczak

    Citation: Stem Cell Research & Therapy 2020 11:29

    Content type: Research

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  36. Endothelial progenitor cells (EPCs) contribute to reendothelialization and neovascularization and protect against vascular injury and ischemia of various organs. We have previously shown downregulation of micr...

    Authors: Chong Zhe Pei, Bo Liu, Ye Ting Li, Lu Fang, Yi Zhang, Yi Gang Li and Shu Meng

    Citation: Stem Cell Research & Therapy 2020 11:28

    Content type: Research

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  37. Vitiligo is an acquired chronic and recurrent skin disease that causes a depigmentation disorder, resulting in selective destruction of melanocytes (MC). However, the mechanism that leads to melanocyte dysfunc...

    Authors: Lifei Zhu, Xi Lin, Lin Zhi, Yushan Fang, Keming Lin, Kai Li and Liangcai Wu

    Citation: Stem Cell Research & Therapy 2020 11:26

    Content type: Research

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  39. Mesenchymal stem cells (MSCs) are a population of pluripotent cells that might be used for treatment of liver disease. However, the efficacy of MSCs for mice with alcoholic hepatitis (AH) and its underlying me...

    Authors: Yue-Meng Wan, Zhi-qiang Li, Qiong Zhou, Chang Liu, Men-Jie Wang, Hui-Xin Wu, Yun-Zhen Mu, Yue-Feng He, Yuan Zhang, Xi-Nan Wu, Yu-Hua Li, Zhi-Yuan Xu, Hua-Mei Wu, Ying Xu, Jin-Hui Yang and Xiao-Fang Wang

    Citation: Stem Cell Research & Therapy 2020 11:24

    Content type: Research

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  41. Bone marrow mesenchymal stem cell (BMSC) transplantation represents a promising therapeutic strategy for ischemic heart disease. However, its effects are hampered by the poor viability of transplanted cells an...

    Authors: Mingzhuo Lin, Xinyue Liu, Haoxiao Zheng, Xiaohui Huang, Yu Wu, Anqing Huang, Hailan Zhu, Yunzhao Hu, Weiyi Mai and Yuli Huang

    Citation: Stem Cell Research & Therapy 2020 11:22

    Content type: Research

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  42. Accumulating evidence shows that mesenchymal stem cells (MSCs) have the potential as a cellular therapy avenue for schistosome-induced liver injury. Extracellular vesicles (EVs) are membranous vesicles release...

    Authors: Liyang Dong, Yanan Pu, Xiaojun Chen, Xin Qi, Lina Zhang, Lei Xu, Wei Li, Yongbin Ma, Sha Zhou, Jifeng Zhu, Yalin Li, Xuefeng Wang and Chuan Su

    Citation: Stem Cell Research & Therapy 2020 11:21

    Content type: Research

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  44. Stem cell-derived sheet engineering has been developed as the next-generation treatment for myocardial infarction (MI) and offers attractive advantages in comparison with direct stem cell transplantation and s...

    Authors: Rui Guo, Masatoshi Morimatsu, Tian Feng, Feng Lan, Dehua Chang, Feng Wan and Yunpeng Ling

    Citation: Stem Cell Research & Therapy 2020 11:19

    Content type: Review

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  45. Profound skeletal muscle wasting and weakness is common after severe burn and persists for years after injury contributing to morbidity and mortality of burn patients. Currently, no ideal treatment exists to i...

    Authors: Yusef Yousuf, Andrea Datu, Ben Barnes, Saeid Amini-Nik and Marc G. Jeschke

    Citation: Stem Cell Research & Therapy 2020 11:18

    Content type: Research

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  46. Neonatal ventilation exacerbates brain injury in lambs with fetal growth restriction (FGR), characterized by neuroinflammation and reduced blood-brain barrier integrity, which is normally maintained by the neu...

    Authors: Atul Malhotra, Margie Castillo-Melendez, Beth J. Allison, Amy E. Sutherland, Ilias Nitsos, Yen Pham, Courtney A. McDonald, Michael C. Fahey, Graeme R. Polglase, Graham Jenkin and Suzanne L. Miller

    Citation: Stem Cell Research & Therapy 2020 11:17

    Content type: Research

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  47. Toll-like receptor 4 (TLR4) ligands such as lipopolysaccharide (LPS) activate immunomodulatory functions and the migration of human mesenchymal stromal cells (hMSCs). Here, we study the migration-related gene ...

    Authors: Sun Hwa Kim, Hae In Choi, Mi Ran Choi, Ga Yeong An, Bert Binas, Kyoung Hwa Jung and Young Gyu Chai

    Citation: Stem Cell Research & Therapy 2020 11:16

    Content type: Research

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  48. In Asherman’s syndrome (AS), intrauterine scarring and fibrotic adhesions lead to menstrual disorders, pregnancy loss, or infertility. A few clinical trials have piloted cell therapy to overcome AS. Understand...

    Authors: Suzanna Queckbörner, Elisabeth Syk Lundberg, Kristina Gemzell-Danielsson and Lindsay C. Davies

    Citation: Stem Cell Research & Therapy 2020 11:15

    Content type: Research

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  49. Persistent epithelial defects (PED), associated with limbal stem cell deficiency (LSCD), require ocular surface reconstruction with a stable corneal epithelium (CE). This study investigated CE reformation usin...

    Authors: Francisco Bandeira, Tze-Wei Goh, Melina Setiawan, Gary Hin-Fai Yam and Jodhbir S. Mehta

    Citation: Stem Cell Research & Therapy 2020 11:14

    Content type: Research

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  50. To explore the effect of aerobic training (AT), resistance training (RT) or a combination of AT and RT (AT+RT) on the function of endothelial progenitor cells (EPCs) in mice with type 2 diabetes and the potent...

    Authors: Lu Zhai, Yuhua Liu, Wenpiao Zhao, Qingyun Chen, Tao Guo, Wei Wei, Zhuchun Luo, Yanfeng Huang, Cui Ma, Feng Huang and Xia Dai

    Citation: Stem Cell Research & Therapy 2020 11:10

    Content type: Research

    Published on:

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Stem Cell Research & Therapy

ISSN: 1757-6512