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  1. Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system capable of immune surveillance. Given their ability to rapidly and effectively recognize and kill aberrant cells, especially tran...

    Authors: Gabrielle M. Robbins, Minjing Wang, Emily J. Pomeroy and Branden S. Moriarity

    Citation: Stem Cell Research & Therapy 2021 12:350

    Content type: Review

    Published on:

  2. Glioma is one of the most common central nervous system malignant tumors, accounting for 45~60% of adult intracranial tumors. However, the clinical treatment of glioma is limited. It is of great significance t...

    Authors: Ruijie Zhang, Peng Li, Heli Lv, Nana Li, Suliang Ren and Wentao Xu

    Citation: Stem Cell Research & Therapy 2021 12:349

    Content type: Research

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  3. Patients with osteoporosis have a high risk of implant loosening due to poor osteointegration, possibly leading to implant failure, implant revision, and refracture. RNA interference therapy is an emerging epi...

    Authors: Wei Liu, Jinghuan Huang, Feng Chen, Dong Xie, Longqing Wang, Cheng Ye, Qi Zhu, Xiang Li, Xiaolin Li and Lili Yang

    Citation: Stem Cell Research & Therapy 2021 12:348

    Content type: Research

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  4. Human bone marrow-derived mesenchymal stem cells (hBMSCs) can differentiate into adipocytes upon stimulation and are considered an appropriate cell source for adipose tissue engineering. In addition to biochem...

    Authors: Shiqi Xiang, Zhong Li, Madalyn R. Fritch, La Li, Sachin Velankar, Yuwei Liu, Jihee Sohn, Natasha Baker, Hang Lin and Rocky S. Tuan

    Citation: Stem Cell Research & Therapy 2021 12:347

    Content type: Research

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  5. The human skin-derived precursors (SKPs) are a good cell source for regeneration. However, the isolation of SKP from human skin is limited. To overcome this drawback, we hypothesized that the component of plan...

    Authors: Yoo-Wook Kwon, Shin-Hyae Lee, Ah-Reum Kim, Beom Joon Kim, Won-Seok Park, Jin Hur, Hyunduk Jang, Han-Mo Yang, Hyun-Jai Cho and Hyo-Soo Kim

    Citation: Stem Cell Research & Therapy 2021 12:346

    Content type: Research

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  6. Adult hippocampal neurogenesis (AHN) is restricted under the pathological conditions of neurodegenerative diseases, especially in Alzheimer’s disease (AD). The drop of AHN reduces neural circuit plasticity, re...

    Authors: Xiaolei Wu, Qi Shen, Zhan Zhang, Di Zhang, Ying Gu and Da Xing

    Citation: Stem Cell Research & Therapy 2021 12:345

    Content type: Research

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  7. The human endometrium in premenopausal women is an active site of physiological angiogenesis, with regenerative cells present, suggesting that the endometrium contains adult angiogenic stem cells. In the conte...

    Authors: Xuemei Fan, Sheng He, Huifang Song, Wenjuan Yin, Jie Zhang, Zexu Peng, Kun Yang, Xiaoyan Zhai, Lingxia Zhao, Hui Gong, Yi Ping, Xiangying Jiao, Sanyuan Zhang, Changping Yan, Hongliang Wang, Ren-Ke Li…

    Citation: Stem Cell Research & Therapy 2021 12:344

    Content type: Research

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  8. The liver possesses a powerful regeneration ability, which is correlated with the stemness of hepatocytes in the portal vein (PV). However, the mechanism underlying the maintenance of hepatocyte stemness has n...

    Authors: Changchun Shao, Xue Yang, Yingying Jing, Xiaojuan Hou, Yihua Huang, Chen Zong, Lu Gao, Wenting Liu, Jinghua Jiang, Fei Ye, Junxia Shi, Qiudong Zhao, Rong Li, Xiaoren Zhang and Lixin Wei

    Citation: Stem Cell Research & Therapy 2021 12:342

    Content type: Research

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  9. Epidermal stem cells (EpSCs) play a vital role in wound healing and skin renewal. Although biomaterial scaffolds have been used for transplantation of EpSCs in wound healing, the ex vivo differentiation of EpS...

    Authors: Zhixiao Lin, Congying Zhao, Zhanjun Lei, Yuheng Zhang, Rong Huang, Bin Lin, Yuchen Dong, Hao Zhang, Jinqing Li and Xueyong Li

    Citation: Stem Cell Research & Therapy 2021 12:341

    Content type: Research

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  10. The preservation or restoration of β cell function in type 1 diabetes (T1D) remains as an attractive and challengeable therapeutic target. Mesenchymal stromal cells (MSCs) are multipotent cells with high capac...

    Authors: Jing Lu, Shan-mei Shen, Qing Ling, Bin Wang, Li-rong Li, Wei Zhang, Duo-duo Qu, Yan Bi and Da-long Zhu

    Citation: Stem Cell Research & Therapy 2021 12:340

    Content type: Research

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  11. The spatiotemporal regulation of essential genes is crucial for controlling the growth and differentiation of cells in a precise manner during regeneration. Recently, optogenetics was considered as a potent te...

    Authors: Delan Huang, Runze Li, Jianhan Ren, Haotian Luo, Weicai Wang and Chen Zhou

    Citation: Stem Cell Research & Therapy 2021 12:339

    Content type: Research

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  12. The use of adipose-derived mesenchymal stromal cell-derived exosomes (ADSC-Exos) may become a new therapeutic method in biomedicine owing to their important role in regenerative medicine. However, the role of ...

    Authors: Hengchen Liu, Mingzhao Zhang, Manyu Shi, Tingting Zhang, Wenjun Lu, Shulong Yang, Qingbo Cui and Zhaozhu Li

    Citation: Stem Cell Research & Therapy 2021 12:338

    Content type: Research

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  13. Mesenchymal stem cells (MSCs) hold promising potential to treat systemic inflammatory diseases including severe acute pancreatitis (SAP). In our previous study, placental chorionic plate-derived MSCs (CP-MSCs)...

    Authors: Qilin Huang, Xiumei Cheng, Chen Luo, Shuxu Yang, Shuai Li, Bing Wang, Xiaohui Yuan, Yi Yang, Yi Wen, Ruohong Liu, Lijun Tang and Hongyu Sun

    Citation: Stem Cell Research & Therapy 2021 12:337

    Content type: Research

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  14. Intra-bone marrow injection (IBMI) in rats is adopted in many studies for stem cell and hematopoietic cell transplantation. IBMI in the tibia or the femur results in severe distress to the animal. Therefore, t...

    Authors: Marwa S. Khattab, Huda O. AbuBakr, Kassem G. El Iraqi, Naglaa A. AbdElKader, Mervat M. Kamel, Khaled Hamed Salem, Julia Steitz and Mamdouh Afify

    Citation: Stem Cell Research & Therapy 2021 12:336

    Content type: Research

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  15. Loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) underlines much of the pathology of Parkinson’s disease (PD), but the existence of an endogenous neurogenic system that could be target...

    Authors: Theodora Mourtzi, Dimitrios Dimitrakopoulos, Dimitrios Kakogiannis, Charalampos Salodimitris, Konstantinos Botsakis, Danai Kassandra Meri, Maria Anesti, Aggeliki Dimopoulou, Ioannis Charalampopoulos, Achilleas Gravanis, Nikolaos Matsokis, Fevronia Angelatou and Ilias Kazanis

    Citation: Stem Cell Research & Therapy 2021 12:335

    Content type: Research

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  16. How to obtain a small interfering RNA (siRNA) vector has become a moot point in recent years. Exosomes (Exo) show advantages of long survival time in vivo, high transmission efficiency, and easy penetration ac...

    Authors: Wei Huang, Mingjia Qu, Lu Li, Tao Liu, Miaoman Lin and Xiaobing Yu

    Citation: Stem Cell Research & Therapy 2021 12:334

    Content type: Research

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  17. Renal fibrosis commonly leads to glomerulosclerosis and renal interstitial fibrosis and the main pathological basis involves tubular atrophy and the abnormal increase and excessive deposition of extracellular ...

    Authors: Yiping Liu, Yan-Yan Su, Qian Yang and Tianbiao Zhou

    Citation: Stem Cell Research & Therapy 2021 12:333

    Content type: Review

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  18. Complement factor H (FH) is the main plasma regulator of the alternative pathway of complement. Genetic and acquired abnormalities in FH cause uncontrolled complement activation amplifying, with the consequent...

    Authors: Federica Casiraghi, Pamela Yossenaidy Rodriguez Ordonez, Nadia Azzollini, Marta Todeschini, Daniela Rottoli, Roberta Donadelli, Roberto Gramignoli, Ariela Benigni, Marina Noris and Giuseppe Remuzzi

    Citation: Stem Cell Research & Therapy 2021 12:332

    Content type: Short report

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  19. Local ischemia and defective osteogenesis are implicated in the progression of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH). Recent studies have revealed that exosomes released from adi...

    Authors: Kai Nan, Yuankai Zhang, Xin Zhang, Dong Li, Yan Zhao, Zhaopu Jing, Kang Liu, Donglong Shang, Zilong Geng and Lihong Fan

    Citation: Stem Cell Research & Therapy 2021 12:331

    Content type: Research

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  20. Co-transplantation of bone marrow cells (BMCs) and mesenchymal stem cells (MSCs) is used as a strategy to improve the outcomes of bone marrow transplantation. Tonsil-derived MSCs (TMSCs) are a promising source...

    Authors: Hyun-Ji Lee, Yu-Hee Kim, Da-Won Choi, Kyung-Ah Cho, Joo-Won Park, Sang-Jin Shin, Inho Jo, So-Youn Woo and Kyung-Ha Ryu

    Citation: Stem Cell Research & Therapy 2021 12:329

    Content type: Research

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  21. Bone marrow-derived mesenchymal stem cells (BM-MSCs) have shown therapeutic potential in various in vitro and in vivo studies in cutaneous wound healing. Furthermore, there are ubiquitous studies highlighting ...

    Authors: Jeffrey D. McBride, Luis Rodriguez-Menocal, Wellington Guzman, Aisha Khan, Ciara Myer, Xiaochen Liu, Sanjoy K. Bhattacharya and Evangelos V. Badiavas

    Citation: Stem Cell Research & Therapy 2021 12:328

    Content type: Research

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  22. Systemic sclerosis (SSc) is a disease that features severe fibrosis of the skin and lacks effective therapy. Bone marrow mesenchymal stem cell (BMSC)-derived extracellular vesicles (EVs) are potential stem cel...

    Authors: Jiahui Jin, Qingjian Ou, Zhe Wang, Haibin Tian, Jing-Ying Xu, Furong Gao, Shuqin Hu, Jie Chen, Juan Wang, Jieping Zhang, Lixia Lu, Caixia Jin, Guo-Tong Xu and Jingjun Zhao

    Citation: Stem Cell Research & Therapy 2021 12:327

    Content type: Research

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  23. Methylsulfonylmethane (MSM) is a nutraceutical compound which has been indicated to counteract osteoarthritis, a cartilage degenerative disorder. In addition, MSM has also been shown to increase osteoblast dif...

    Authors: Luca Dalle Carbonare, Jessica Bertacco, Giulia Marchetto, Samuele Cheri, Michela Deiana, Arianna Minoia, Natascia Tiso, Monica Mottes and Maria Teresa Valenti

    Citation: Stem Cell Research & Therapy 2021 12:326

    Content type: Research

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  24. Gastric cancer stem cells (CSCs) are the main causes of metastasis and drug resistance. We previously indicated that miR-375 can inhibit Helicobacter pylori-induced gastric carcinogenesis; here, we aim to explore...

    Authors: Haiwei Ni, Hai Qin, Cheng Sun, Yichen Liu, Guojing Ruan, Qianqian Guo, Tao Xi, Yingying Xing and Lufeng Zheng

    Citation: Stem Cell Research & Therapy 2021 12:325

    Content type: Research

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  25. Ulcerative colitis (UC) is a chronic, relapsing, and non-specific inflammatory bowel disease, and the current treatment strategies were mainly used to relieve symptoms or for maintenance. Endometrial regenerat...

    Authors: Dingding Yu, Yiming Zhao, Hongda Wang, Dejun Kong, Wang Jin, Yonghao Hu, Yafei Qin, Baoren Zhang, Xiang Li, Jingpeng Hao, Guangming Li and Hao Wang

    Citation: Stem Cell Research & Therapy 2021 12:324

    Content type: Research

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  26. Necrotizing enterocolitis (NEC) is a devastating disease predominately affecting neonates. Despite therapeutic advances, NEC remains the leading cause of mortality due to gastrointestinal conditions in neonate...

    Authors: Ruijie Zeng, Jinghua Wang, Zewei Zhuo, Yujun Luo, Weihong Sha and Hao Chen

    Citation: Stem Cell Research & Therapy 2021 12:323

    Content type: Review

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  27. Doxorubicin (DOX), a widely used chemotherapeutic agent, can cause neurodegeneration in the brain, which leads to a condition known as chemobrain. In fact, chemobrain is a deteriorating condition which adverse...

    Authors: Marwa O. El-Derany and Mohamed H. Noureldein

    Citation: Stem Cell Research & Therapy 2021 12:322

    Content type: Research

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  28. The human fetal liver is a critical organ for prenatal hematopoiesis, the study of which offers insights into niche signals that regulate the fates of hematopoietic stem and progenitor cells (HSPCs) during fet...

    Authors: Yoon Jung Choi, Adam M. Heck, Brian J. Hayes, Daniel Lih, Samuel G. Rayner, Brandon Hadland and Ying Zheng

    Citation: Stem Cell Research & Therapy 2021 12:321

    Content type: Short report

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  29. Mesenchymal stem/stromal cells (MSC) represent adult cells with multipotent capacity. Besides their capacity to differentiate into multiple lineages in vitro and in vivo, increasing evidence points towards the...

    Authors: Catalina-Iolanda Marinescu, Mihai Bogdan Preda and Alexandrina Burlacu

    Citation: Stem Cell Research & Therapy 2021 12:319

    Content type: Method

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  30. Fat tissue (FT) has been used for many years in regenerative surgery as a bioactive material through the lipofilling/fat graft (F-GRF)–nano-fat technique, as a bioactive scaffold when it was enriched with adip...

    Authors: Pietro Gentile, Aris Sterodimas, Claudio Calabrese and Simone Garcovich

    Citation: Stem Cell Research & Therapy 2021 12:318

    Content type: Review

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  31. Age-related diminished ovarian reserve (AR-DOR) reduced the quality of oocytes, resulting in decreased female fertility. Aging is tightly related to abnormal distribution and function of mitochondria, while mi...

    Authors: Hanwen Liu, Chunyan Jiang, Boya La, Meng Cao, Song Ning, Jing Zhou, Zhengjie Yan, Chuyu Li, Yugui Cui, Xiang Ma, Meilian Wang, Li Chen, Youjia Yu, Feng Chen, Yuexin Zhang, Huimin Wu…

    Citation: Stem Cell Research & Therapy 2021 12:317

    Content type: Research

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  32. Coronavirus disease 2019 (COVID-19) may result in a life-threatening condition due to a hyperactive immune reaction to severe acute respiratory syndrome-coronavirus-2 infection, for which no effective treatmen...

    Authors: Rachele Ciccocioppo, Davide Gibellini, Giuseppe Astori, Martina Bernardi, Angela Bozza, Katia Chieregato, Francesca Elice, Stefano Ugel, Simone Caligola, Francesco De Sanctis, Stefania Canè, Alessandra Fiore, Rosalinda Trovato, Antonio Vella, Varvara Petrova, Giuseppe Amodeo…

    Citation: Stem Cell Research & Therapy 2021 12:316

    Content type: Short report

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  33. Exosomes as the main therapeutic vectors of mesenchymal stem cells (MSC) for inflammatory bowel disease (IBD) treatment and its mechanism remain unexplored. Tumor necrosis factor-α stimulated gene 6 (TSG-6) is...

    Authors: Shaopeng Yang, Xiaonan Liang, Jia Song, Chenyang Li, Airu Liu, Yuxin Luo, Heran Ma, Yi Tan and Xiaolan Zhang

    Citation: Stem Cell Research & Therapy 2021 12:315

    Content type: Research

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  34. The major barriers to mesenchymal stem cell (MSC) therapy in rheumatoid arthritis (RA) are a low extent of tissue regeneration and insufficient immunomodulation after cell transplantation. In addition, the rol...

    Authors: Sung-Tai Wei, Yen-Chih Huang, Jung-Ying Chiang, Chia-Ching Lin, Yu-Jung Lin, Woei-Cherng Shyu, Hui-Chen Chen and Chia-Hung Hsieh

    Citation: Stem Cell Research & Therapy 2021 12:314

    Content type: Research

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  35. Mesenchymal stem cells including adipose-derived stem cells (ASCs) have a considerable potential in the field of translational medicine. Unfortunately, multiple factors (e.g., older age, co-existing diabetes, ...

    Authors: Sen Ren, Hewei Xiong, Jing Chen, Xiaofan Yang, Yutian Liu, Jiahe Guo, Tao Jiang, Zhao Xu, Meng Yuan, Yang Liu, Nan Zhou, Hongrui Chen, Wenqing Li, Hans-Günther Machens and Zhenbing Chen

    Citation: Stem Cell Research & Therapy 2021 12:313

    Content type: Research

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  36. Small hepatocyte-like progenitor cells (SHPCs) appear to form transient clusters in rat livers treated with retrorsine (Ret) and 70% partial hepatectomy (PH). We previously reported that the expansion of SHPCs...

    Authors: Norihisa Ichinohe, Masayuki Ishii, Naoki Tanimizu, Toru Mizuguchi, Yusuke Yoshioka, Takahiro Ochiya, Hiromu Suzuki and Toshihiro Mitaka

    Citation: Stem Cell Research & Therapy 2021 12:312

    Content type: Research

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  37. Fat grafting has been regarded as a promising approach for regenerative therapy. Given the rapidly aging population, better understanding of the effect of age on fat graft outcomes and the underlying mechanism...

    Authors: Xihang Chen, Jingwei Feng, Qiang Chang, Feng Lu and Yi Yuan

    Citation: Stem Cell Research & Therapy 2021 12:311

    Content type: Research

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  38. Mobilization failure may occur when the conventional hematopoietic stem cells (HSCs) mobilization agent granulocyte colony-stimulating factor (G-CSF) is used alone, new regimens were developed to improve mobil...

    Authors: Chengxin Luo, Li Wang, Guixian Wu, Xiangtao Huang, Yali Zhang, Yanni Ma, Mingling Xie, Yanni Sun, Yarui Huang, Zhen Huang, Qiuyue Song, Hui Li, Yu Hou, Xi Li, Shuangnian Xu and Jieping Chen

    Citation: Stem Cell Research & Therapy 2021 12:310

    Content type: Research

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  39. The intestine is particularly sensitive to moderate-high radiation dose and the development of gastrointestinal syndrome (GIS) leads to the rapid loss of intestinal mucosal integrity, resulting in bacterial in...

    Authors: Lydia Bensemmane, Claire Squiban, Christelle Demarquay, Noëlle Mathieu, Marc Benderitter, Bernard Le Guen, Fabien Milliat and Christine Linard

    Citation: Stem Cell Research & Therapy 2021 12:309

    Content type: Research

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  40. Deleterious cutaneous tissue damages could result from exposure to thermal trauma, which could be ameliorated structurally and functionally through therapy via the most multipotent progenitor bone marrow mesen...

    Authors: Doaa Ramadan I. Abdel-Gawad, Walaa A. Moselhy, Rasha Rashad Ahmed, Hessah Mohammed Al-Muzafar, Kamal Adel Amin, Maha Mohamed Amin, El-Shaymaa El-Nahass and Khaled Abbas Helmy Abdou

    Citation: Stem Cell Research & Therapy 2021 12:308

    Content type: Research

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  41. The stem cells of the stem cell banks have prominent problems for insufficient sources, easy contamination, unstable biological characteristics after serial subcultivations, and high cost.

    Authors: Bao-Shi Fan, Yang Liu, Ji-Ying Zhang, You-Rong Chen, Meng Yang and Jia-Kuo Yu

    Citation: Stem Cell Research & Therapy 2021 12:307

    Content type: Review

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  42. Endometrial mesenchymal-like stromal/stem cells (eMSCs) have been proposed as adult stem cells contributing to endometrial regeneration. One set of perivascular markers (CD140b&CD146) has been widely used to e...

    Authors: Dandan Cao, Rachel W. S. Chan, Ernest H. Y. Ng, Kristina Gemzell-Danielsson and William S. B. Yeung

    Citation: Stem Cell Research & Therapy 2021 12:306

    Content type: Research

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  43. Graves’ ophthalmopathy (GO) is a disorder, in which orbital connective tissues get in inflammation and increase in volume. Stimulants such as thyroid-stimulating hormone (TSH), insulin-like growth factor 1(IGF...

    Authors: Mira Park, Jae Yeon Kim, Jun Mo Kang, Hey Jin Lee, Jasvinder Paul Banga, Gi Jin Kim and Helen Lew

    Citation: Stem Cell Research & Therapy 2021 12:304

    Content type: Research

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  44. Nerve injuries are debilitating, leading to long-term motor deficits. Remyelination and axonal growth are supported and enhanced by growth factor and cytokines. Combination of nerve guidance conduits (NGCs) wi...

    Authors: Diego Noé Rodríguez-Sánchez, Giovana Boff Araujo Pinto, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira, Ana Livia Carvalho Bovolato, Marcio de Carvalho, Jorge Vicente Lopes da Silva, Janaina de Andréa Dernowsek, Marjorie Golim, Benedito Barraviera, Rui Seabra Ferreira, Elenice Deffune, Mathues Bertanha and Rogério Martins Amorim

    Citation: Stem Cell Research & Therapy 2021 12:303

    Content type: Research

    Published on:

  45. Dental pulp stem cells (DPSCs) have been developed as a potential source of mesenchymal stem cells (MSCs) for regeneration of dental pulp and other tissues. However, further strategies to isolate highly functi...

    Authors: Mohammed Zayed, Koichiro Iohara, Hideto Watanabe, Mami Ishikawa, Michiyo Tominaga and Misako Nakashima

    Citation: Stem Cell Research & Therapy 2021 12:302

    Content type: Research

    Published on:

  46. Powerful constitutive and inducible transgenic / bitransgenic / tritransgenic murine models of breast cancer have been used over the past two decades to shed light on the molecular mechanisms by which the give...

    Authors: Christine Nguyen, Julie P. T. Nguyen, Arnav P. Modi, Ihsaan Ahmad, Sarah C. Petrova, Stuart D. Ferrell Jr, Sabrina R. Wilhelm, Yin Ye, Dorthe Schaue and Sanford H. Barsky

    Citation: Stem Cell Research & Therapy 2021 12:301

    Content type: Research

    Published on:

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