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  1. With the increasing incidence of cartilage-related diseases such as osteoarthritis (OA) and intervertebral disc degeneration (IDD), heavier financial and social burdens need to be faced. Unfortunately, there i...

    Authors: Jian Zhu, Wei Yu, Yitian Wang, Kaishun Xia, Yuluan Huang, Ankai Xu, Qixin Chen, Bing Liu, Huimin Tao, Fangcai Li and Chengzhen Liang

    Citation: Stem Cell Research & Therapy 2019 10:344

    Content type: Review

    Published on:

  2. Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidate agents for treating critical-sized bone defects; they promote angiogenesis and may be an alternative to cell therapy. In this ...

    Authors: Bo Liang, Jia-Ming Liang, Jia-Ning Ding, Jia Xu, Jian-Guang Xu and Yi-Min Chai

    Citation: Stem Cell Research & Therapy 2019 10:335

    Content type: Research

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  3. Acute graft-versus-host disease (aGvHD), post-allogeneic hematopoietic stem cell transplantation, is associated with high mortality rates in patients not responding to standard line care with steroids. Adoptiv...

    Authors: Caroline Gavin, Erik Boberg, Lena Von Bahr, Matteo Bottai, Anton Törnqvist Andrén, Annika Wernerson, Lindsay C. Davies, Rachael V. Sugars and Katarina Le Blanc

    Citation: Stem Cell Research & Therapy 2019 10:334

    Content type: Letter

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  4. Long-term diabetes-associated complications are the major causes of morbidity and mortality in individuals with diabetes. These diabetic complications are closely linked to immune system activation along with ...

    Authors: Songyan Yu, Yu Cheng, Linxi Zhang, Yaqi Yin, Jing Xue, Bing Li, Zhengyuan Gong, Jieqing Gao and Yiming Mu

    Citation: Stem Cell Research & Therapy 2019 10:333

    Content type: Research

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  5. Mesenchymal stem cells (MSCs) have been explored as promising tools for treatment of several neurological and neurodegenerative diseases. MSCs release abundant extracellular vesicles (EVs) containing a variety...

    Authors: Victor Bodart-Santos, Luiza R. P. de Carvalho, Mariana A. de Godoy, André F. Batista, Leonardo M. Saraiva, Luize G. Lima, Carla Andreia Abreu, Fernanda G. De Felice, Antonio Galina, Rosalia Mendez-Otero and Sergio T. Ferreira

    Citation: Stem Cell Research & Therapy 2019 10:332

    Content type: Research

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  6. Experimental and clinical trials have demonstrated the efficiency of bone marrow-derived mesenchymal stromal/stem cells (bMSCs) in the treatment of myocardial infarction. However, after intravenous injection, ...

    Authors: Dong-Mei Xie, Yuan-Long Li, Jie Li, Qinglang Li, Guihua Lu, Yuansheng Zhai, Juhong Zhang, Zhibin Huang and Xiuren Gao

    Citation: Stem Cell Research & Therapy 2019 10:331

    Content type: Research

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  7. The existing cell surface markers used for sorting glioma stem cells (GSCs) have obvious limitations, such as vulnerability to the enzymatic digestion and time-consuming labeling procedure. Reduced nicotinamid...

    Authors: Ye Yuan, Zexuan Yan, Jingya Miao, Ruili Cai, Mengsi Zhang, Yanxia Wang, Lihong Wang, Weiqi Dang, Di Wang, Dongfang Xiang, Yan Wang, Peng Zhang, Youhong Cui, Xiuwu Bian and Qinghua Ma

    Citation: Stem Cell Research & Therapy 2019 10:330

    Content type: Research

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  8. Renal proximal tubular epithelial cells (RPTEC) are dysfunctional in diabetic kidney disease (DKD). Mesenchymal stromal cells (MSC) may modulate DKD pathogenesis through anti-inflammatory mediators. This study...

    Authors: Md Nahidul Islam, Tomás P. Griffin, Elizabeth Sander, Stephanie Rocks, Junaid Qazi, Joana Cabral, Jasmin McCaul, Tara McMorrow and Matthew D. Griffin

    Citation: Stem Cell Research & Therapy 2019 10:329

    Content type: Research

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  9. Previous studies including ours have demonstrated a critical function of the transcription factor ETV2 (ets variant 2; also known as ER71) in determining the fate of cardiovascular lineage development. However...

    Authors: Ju Young Kim, Dong Hun Lee, Joo Kyung Kim, Hong Seo Choi, Bhakti Dwivedi, Manali Rupji, Jeanne Kowalski, Stefan J. Green, Heesang Song, Won Jong Park, Ji Young Chang, Tae Min Kim and Changwon Park

    Citation: Stem Cell Research & Therapy 2019 10:328

    Content type: Short report

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  10. Stem cells are considered the fundamental underpinnings of tissue biology. The stem cell microenvironment provides factors and elements that play significant roles in controlling the cell fate direction. The b...

    Authors: Pan Zhang, Chen Zhang, Jing Li, Jiyang Han, Xiru Liu and Hui Yang

    Citation: Stem Cell Research & Therapy 2019 10:327

    Content type: Review

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  11. When the deer antler is cast, it leaves a cutaneous wound that can achieve scarless healing due to the presence of antler stem cells (ASCs). This provides an opportunity to study regenerative wound healing.

    Authors: Xiaoli Rong, Wenhui Chu, Haiying Zhang, Yusu Wang, Xiaoyan Qi, Guokun Zhang, Yimin Wang and Chunyi Li

    Citation: Stem Cell Research & Therapy 2019 10:326

    Content type: Research

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  12. Multiple sclerosis (MS) is one of the most common autoimmune diseases of the central nervous system (CNS). CNS has its own unique structural and functional features, while the lack of precision regulatory elem...

    Authors: Xi Wang, Wantong Zhai, Jiahui Zhu, Wei Zhao, Xiaoyi Zou, Siying Qu, Shenyue Wang, Zhongze He, Zhaoying Li, Lingyang Wang, Bo Sun and Hulun Li

    Citation: Stem Cell Research & Therapy 2019 10:325

    Content type: Research

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  13. As the precursors of sperm and eggs, human primordial germ cells (hPGCs) emerge as early as weeks 2 to 3 of post-implantation development. Recently, robust hPGC induction models have been established in vitro ...

    Authors: Zili Li, Fang Fang, Qian Zhao, Honggang Li and Chengliang Xiong

    Citation: Stem Cell Research & Therapy 2019 10:324

    Content type: Research

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  14. Our study sought to investigate the therapeutic effects and mechanisms of miR-326-5p-overexpressing endothelial progenitor cells (EPCs) on acute myocardial infarction (AMI).

    Authors: Xiaoting Li, Xiang Xue, Yuejun Sun, Lei Chen, Ting Zhao, Wentao Yang, Yongbing Chen and Zhiwei Zhang

    Citation: Stem Cell Research & Therapy 2019 10:323

    Content type: Research

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  15. Human pancreata contain many types of cells, such as endocrine islets, acinar, ductal, fat, and mesenchymal stromal cells (MSCs). MSCs are important and shown to have a promising therapeutic potential to treat...

    Authors: Bashar Khiatah, Meirigeng Qi, Weiting Du, Kuan T-Chen, Kayleigh M. van Megen, Rachel G. Perez, Jeffrey S. Isenberg, Fouad Kandeel, Bart O. Roep, Hsun Teresa Ku and Ismail H. Al-Abdullah

    Citation: Stem Cell Research & Therapy 2019 10:322

    Content type: Research

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  16. Damaged endothelial cells and downregulated osteogenic ability are two key pathogenic mechanisms of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH). Recent studies suggested that transplan...

    Authors: Rongtai Zuo, Lingchi Kong, Mengwei Wang, Wenbo Wang, Jia Xu, Yimin Chai, Junjie Guan and Qinglin Kang

    Citation: Stem Cell Research & Therapy 2019 10:321

    Content type: Research

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  17. The inflammation and regeneration process may be accompanied by the shift in the M1/M2 polarization of macrophages to adapt to extracellular signals. How the macrophages responded to the altered immunological ...

    Authors: Jiaying Liu, Bin Chen, Jun Bao, Yangheng Zhang, Lang Lei and Fuhua Yan

    Citation: Stem Cell Research & Therapy 2019 10:320

    Content type: Research

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  18. Metabolomics is the systemic study of the unique fingerprints of metabolites involved in cellular processes and biochemical reactions. The metabolomic approach is useful in diagnosing and predicting the develo...

    Authors: Juryun Kim, Sunyoung Christina Kang, Na Eun Yoon, Yena Kim, Jinhyeok Choi, Narae Park, Hyerin Jung, Byung Hwa Jung and Ji Hyeon Ju

    Citation: Stem Cell Research & Therapy 2019 10:319

    Content type: Research

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  19. Retinal inflammation affecting the neurovascular unit may play a role in the development of visual deficits following mild traumatic brain injury (mTBI). We have shown that concentrated conditioned media from ...

    Authors: Kumar Abhiram Jha, Mickey Pentecost, Raji Lenin, Jordy Gentry, Lada Klaic, Nobel Del Mar, Anton Reiner, Chuan He Yang, Lawrence M. Pfeffer, Nicolas Sohl and Rajashekhar Gangaraju

    Citation: Stem Cell Research & Therapy 2019 10:318

    Content type: Research

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  20. Human fibroblasts can be reprogrammed into induced hepatocyte-like cells through the expression of a set of transcription factors. Although the generation of induced hepatocyte-like cells by HNF4A, HNF1A, and ...

    Authors: Maria Ballester, Miguel Bolonio, Ramon Santamaria, José V. Castell, Carmen Ribes-Koninckx and Roque Bort

    Citation: Stem Cell Research & Therapy 2019 10:317

    Content type: Research

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  21. Serum-free xenogen-free defined media and continuous controlled physiological cell culture conditions have been developed for stem cell therapeutics, but the effect of these conditions on the relative potency ...

    Authors: Seth Mount, Pushpinder Kanda, Sandrine Parent, Saad Khan, Connor Michie, Liliana Davila, Vincent Chan, Ross A. Davies, Haissam Haddad, David Courtman, Duncan J. Stewart and Darryl R. Davis

    Citation: Stem Cell Research & Therapy 2019 10:316

    Content type: Research

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  22. Hepatocyte nuclear factor-1 alpha (HNF-1α) is a transcription factor expressed predominantly in the liver among other organs. Structurally, it contains POU-homeodomain that binds to DNA and form proteins that ...

    Authors: Xue Wang, Waseem Hassan, Jing Zhao, Sahar Bakht, Yunjuan Nie, Ying Wang, Qingfeng Pang and Zhaohui Huang

    Citation: Stem Cell Research & Therapy 2019 10:315

    Content type: Review

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  23. Stem cell-based therapies raise hope for cell replacement and provide opportunity for cardiac regenerative medicine and tumor therapy. Extracellular vesicles are a membrane-enclosed intercellular delivery syst...

    Authors: Hargita Hegyesi, Nikolett Sándor, Géza Sáfrány, Virág Lovas, Árpád Kovács, Angéla Takács, László Kőhidai, Lilla Turiák, Ágnes Kittel, Krisztina Pálóczi, Lóránd Bertók and Edit Irén Buzás

    Citation: Stem Cell Research & Therapy 2019 10:313

    Content type: Short report

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  24. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is one of the new therapeutic strategies for treating ischemic brain and heart tissues. However, the poor survival rate of transplanted BMSCs in...

    Authors: Jiankang Fang, Xia Zhao, Shuai Li, Xingan Xing, Haitao Wang, Philip Lazarovici and Wenhua Zheng

    Citation: Stem Cell Research & Therapy 2019 10:312

    Content type: Research

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  25. The attainment of extensive neurological function recovery remains the key challenge for the treatment of traumatic brain injury (TBI). Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) has...

    Authors: Ke Wu, Dongdong Huang, Can Zhu, Ella A. Kasanga, Ying Zhang, Enxing Yu, Hengli Zhang, Zhihui Ni, Sheng Ye, Chunli Zhang, Jiangnan Hu, Qichuan Zhuge and Jianjing Yang

    Citation: Stem Cell Research & Therapy 2019 10:311

    Content type: Research

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  26. Spermatogonial stem cell transplantation (SSCT) is a promising therapy in restoring the fertility of childhood cancer survivors. However, the low efficiency of SSCT is a significant concern. SSCT could be impr...

    Authors: Prashant Kadam, Elissavet Ntemou, Jaime Onofre, Dorien Van Saen and Ellen Goossens

    Citation: Stem Cell Research & Therapy 2019 10:310

    Content type: Research

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  27. Adipose tissue-derived mesenchymal stem cells (ASCs) offer a promising cell source for therapeutic applications in musculoskeletal disorders. The appropriate selection of ASCs from various fat depots for cell-...

    Authors: Stefan Arnhold, Mohamed I. Elashry, Michele C. Klymiuk and Florian Geburek

    Citation: Stem Cell Research & Therapy 2019 10:309

    Content type: Research

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  28. We used multimodal compositional magnetic resonance imaging (MRI) techniques, combined with clinical outcomes, to differentiate the alternations of composition in repair cartilage with allogeneic human adipose...

    Authors: Xinxin Zhao, Jingjing Ruan, Hui Tang, Jia Li, Yingxuan Shi, Meng Li, Suke Li, Cuili Xu, Qing Lu and Chengxiang Dai

    Citation: Stem Cell Research & Therapy 2019 10:308

    Content type: Research

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  29. Adipose tissue-derived mesenchymal stem cells (ADSCs) are promising candidates for regenerative medicine. However, long-term in vitro passaging leads to stemness loss and cell senescence of ADSCs, resulting in...

    Authors: Naishun Liao, Yingjun Shi, Cuilin Zhang, Youshi Zheng, Yingchao Wang, Bixing Zhao, Yongyi Zeng, Xiaolong Liu and Jingfeng Liu

    Citation: Stem Cell Research & Therapy 2019 10:306

    Content type: Research

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  30. Within the last years, the interest in physical exercise as non-invasive stimulus influencing circulating hematopoietic stem and progenitor cell (CPC) concentrations has constantly grown. Cell estimates are of...

    Authors: Julia M. Kröpfl, Michelle Schmid, Yvonne Di Marzio, Karine Schreiber and Christina M. Spengler

    Citation: Stem Cell Research & Therapy 2019 10:305

    Content type: Research

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  31. There are currently no effective treatments available for patients with irreversible loss of salivary gland (SG) function caused by radiation therapy for head and neck cancer. In this study, we have developed ...

    Authors: Takashi I, Yoshinori Sumita, Takako Yoshida, Ryo Honma, Mayumi Iwatake, Jorge Luis Montenegro Raudales, Tomoko Shizuno, Shinichiro Kuroshima, Haruchika Masuda, Makoto Seki, Simon D. Tran, Takayuki Asahara and Izumi Asahina

    Citation: Stem Cell Research & Therapy 2019 10:304

    Content type: Research

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  32. A refractory wound is a typical complication of diabetes and is a common outcome after surgery. Current approaches have difficulty in improving wound healing. Recently, non-expanded stromal vascular fraction (...

    Authors: Hongsen Bi, Hui Li, Chen Zhang, Yiqing Mao, Fangfei Nie, Ying Xing, Wuga Sha, Xi Wang, David M. Irwin and Huanran Tan

    Citation: Stem Cell Research & Therapy 2019 10:302

    Content type: Research

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  33. Placenta-derived MSCs (P-MSCs) represent a promising tool for cell-based therapeutic applications. However, the increasing demand for P-MSCs in clinical trials makes high quality and large number of P-MSCs man...

    Authors: Qilin Huang, Yi Yang, Chen Luo, Yi Wen, Ruohong Liu, Shuai Li, Tao Chen, Hongyu Sun and Lijun Tang

    Citation: Stem Cell Research & Therapy 2019 10:301

    Content type: Research

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  34. Systemic inflammatory response syndrome (SIRS) is common in severe fulminant hepatic failure (FHF) and has a high mortality rate (20–50%) due to irreversible cerebral edema or sepsis. Stem cell-based treatment...

    Authors: Shobha Regmi, Shiva Pathak, Tung Pham Thanh, Tiep Tien Nguyen, Jong-Hyuk Sung, Simmyung Yook, Jong Oh. Kim, Chul Soon Yong, Inho Choi, Kyoung-Oh Doh, Pil-Hoon Park, Jun-Beom Park, Yoojin Seo, Bieong-Kil Kim, Dong-Mok Lee, Ik-Jae Moon…

    Citation: Stem Cell Research & Therapy 2019 10:230

    Content type: Research

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  35. Bone marrow mesenchymal stem cells (MSCs) are among the most common cell types to be used and studied for cardiac regeneration. Low survival rate and difficult retention of delivered MSCs in infarcted heart re...

    Authors: Peisen Huang, Li Wang, Qing Li, Jun Xu, Junyan Xu, Yuyan Xiong, Guihao Chen, Haiyan Qian, Chen Jin, Yuan Yu, Jiandong Liu, Li Qian and Yuejin Yang

    Citation: Stem Cell Research & Therapy 2019 10:300

    Content type: Research

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  36. Many adult women younger than 40 years old have premature ovarian failure (POF) and infertility. Previous studies confirmed that different tissue-derived stem cells could restore ovarian function and folliculo...

    Authors: Rongxia Liu, Xiaoyu Zhang, Zhenhai Fan, Yuying Wang, Guanping Yao, Xue Wan, Zulin Liu, Bing Yang and Limei Yu

    Citation: Stem Cell Research & Therapy 2019 10:299

    Content type: Research

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  37. Although tissue-engineered cartilage has been broadly studied, complete integration of regenerated cartilage with residual cartilage is still difficult for the inferior mechanical and biochemical feature of ne...

    Authors: Baixiang Cheng, Teng Tu, Xiao Shi, Yanzheng Liu, Ying Zhao, Yinhua Zhao, Yijie Li, Hui Chen, Yongjin Chen and Min Zhang

    Citation: Stem Cell Research & Therapy 2019 10:298

    Content type: Research

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  38. Accumulation of vascular smooth muscle cells (VSMCs) within the neointimal region is a hallmark of atherosclerosis and vessel injury. Evidence has shown that Sca-1-positive (Sca-1+) progenitor cells residing i...

    Authors: Yan Wu, Xin Liu, Ling-Yun Guo, Lei Zhang, Fei Zheng, Shan Li, Xing-Yuan Li, Ye Yuan, Yu Liu, Yu-wen Yan, Shi-You Chen, Jia-Ning Wang, Jin-xuan Zhang and Jun-Ming Tang

    Citation: Stem Cell Research & Therapy 2019 10:294

    Content type: Research

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  39. The field of regenerative medicine provides enormous opportunities for generating beta cells from different stem cell sources for cellular therapy. Even though insulin-secreting cells can be generated from a v...

    Authors: Nimshitha Pavathuparambil Abdul Manaph, Kisha N. Sivanathan, Jodie Nitschke, Xin-Fu Zhou, Patrick T. Coates and Christopher John Drogemuller

    Citation: Stem Cell Research & Therapy 2019 10:293

    Content type: Review

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  40. In the field of regenerative medicine, delivery of human adipose-derived mesenchymal stem/stromal cells (hASCs) has shown great promise to promote wound healing. However, a hostile environment of the injured t...

    Authors: Jasmi Kiiskinen, Arto Merivaara, Tiina Hakkarainen, Minna Kääriäinen, Susanna Miettinen, Marjo Yliperttula and Raili Koivuniemi

    Citation: Stem Cell Research & Therapy 2019 10:292

    Content type: Research

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  41. The lack of anti-fibrotic agents targeting intestinal fibrosis is a large unmet need in inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis. Previous studies have found that perinatal...

    Authors: Yoon Jeong Choi, Jun Bon Koo, Hee Yeon Kim, Jin Won Seo, Eun Jeong Lee, Woo Ram Kim, Joo Young Cho, Ki Baik Hahm, Sung Pyo Hong, Duk Hwan Kim and Jun-Hwan Yoo

    Citation: Stem Cell Research & Therapy 2019 10:291

    Content type: Research

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  42. Lung transplantation is a life-saving surgical replacement of diseased lungs in patients with end-stage respiratory malfunctions. Despite remarkable short-term recovery, long-term lung survival continues to fa...

    Authors: Mohammad Afzal Khan, Fatimah Alanazi, Hala Abdalrahman Ahmed, Talal Shamma, Kilian Kelly, Mohamed A. Hammad, Abdullah O. Alawad, Abdullah Mohammed Assiri and Dieter Clemens Broering

    Citation: Stem Cell Research & Therapy 2019 10:290

    Content type: Research

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  43. Stem cell-derived pancreatic β-like cells hold great promise for treating diabetes. Gallbladder belongs to the extrahepatic bile duct system and possesses stem-like cells. These stem cells could be expanded in...

    Authors: Fei Chen, Tuo Li, Yu Sun, Qinggui Liu, Tao Yang, Jiajia Chen, Haiying Zhu, Yongquan Shi, Yi-Ping Hu and Min-Jun Wang

    Citation: Stem Cell Research & Therapy 2019 10:289

    Content type: Research

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  44. After the initial investigations into applications of mesenchymal stem cells (MSCs) for cell therapy, there was increased interest in their secreted soluble factors. Following studies of MSCs and their secrete...

    Authors: Kyong-Su Park, Elga Bandeira, Ganesh V. Shelke, Cecilia Lässer and Jan Lötvall

    Citation: Stem Cell Research & Therapy 2019 10:288

    Content type: Review

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  45. miRNA expression profiles in ectopic endometrium (EC) serving as pathophysiologic genetic fingerprints contribute to determining endometriosis progression; however, the underlying molecular mechanisms remain u...

    Authors: Chen-Fei Zhou, Min-Juan Liu, Wei Wang, Sha Wu, Yu-Xin Huang, Guo-Bin Chen, Li-Min Liu, Dong-Xian Peng, Xue-Feng Wang, Xu-Zi Cai, Xiao-Xuan Li, Wan-Qin Feng and Ying Ma

    Citation: Stem Cell Research & Therapy 2019 10:287

    Content type: Research

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  46. Mesenchymal stromal cells (MSCs) are used in over 800 clinical trials mainly due to their immune inhibitory activity. Umbilical cord (UC), the second leading source of clinically used MSCs, is usually cut in s...

    Authors: Anton Selich, Katharina Zimmermann, Michel Tenspolde, Oliver Dittrich-Breiholz, Constantin von Kaisenberg, Axel Schambach and Michael Rothe

    Citation: Stem Cell Research & Therapy 2019 10:285

    Content type: Research

    Published on:

  47. Cryopreservation of fat grafts facilitates reinjection for later use. However, low temperature and thawing can disrupt tissues and cause lipid leakage, which raises safety concerns. Here, we compared the cryop...

    Authors: Jingwei Feng, Wansheng Hu, Mimi Lalrimawii Fanai, Shengqian Zhu, Jing Wang, Junrong Cai and Feng Lu

    Citation: Stem Cell Research & Therapy 2019 10:283

    Content type: Research

    Published on:

  48. Recent studies suggested that miR-17~106 family was involved in the regulation of neural stem/progenitor cells (NPCs). However, distinct function of each family member was reported in regulating stem cells within...

    Authors: Xiaohuan Xia, Hongfang Lu, Chunhong Li, Yunlong Huang, Yi Wang, Xiaoyu Yang and Jialin C. Zheng

    Citation: Stem Cell Research & Therapy 2019 10:282

    Content type: Research

    Published on:

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