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  1. Age-related bone loss plays a vital role in the development of osteoporosis and osteoporotic fracture. Bone marrow stromal cell (BMSC) senescence is highly associated with osteoporosis and limits the applicati...

    Authors: Lingxian Yi, Yue Ju, Ying He, Xiushan Yin, Ye Xu and Tujun Weng

    Citation: Stem Cell Research & Therapy 2021 12:45

    Content type: Research

    Published on:

  2. To investigate the in vitro and in vivo anti-inflammatory/anti-fibrotic capacity of IFP-MSC manufactured as 3D spheroids. Our hypothesis is that IFP-MSC do not require prior cell priming to acquire a robust im...

    Authors: Dimitrios Kouroupis, Melissa A. Willman, Thomas M. Best, Lee D. Kaplan and Diego Correa

    Citation: Stem Cell Research & Therapy 2021 12:44

    Content type: Research

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  3. Mesenchymal stem cell (MSC) therapy shows great promise for diabetic kidney disease (DKD) patients. Research has been carried out on this topic in recent years. The main goals of this paper are to evaluate the...

    Authors: Wenshan Lin, Hong-Yan Li, Qian Yang, Guangyong Chen, Shujun Lin, Chunling Liao and Tianbiao Zhou

    Citation: Stem Cell Research & Therapy 2021 12:43

    Content type: Research

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  4. Derivation of osteoblast-like cells from human pluripotent stem cells (hPSCs) is a popular topic in bone tissue engineering. Although many improvements have been achieved, the low induction efficiency because ...

    Authors: Ping Zhou, Jia-Min Shi, Jing-E Song, Yu Han, Hong-Jiao Li, Ya-Meng Song, Fang Feng, Jian-Lin Wang, Rui Zhang and Feng Lan

    Citation: Stem Cell Research & Therapy 2021 12:41

    Content type: Research

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  5. Mesenchymal stem cell (MSC)-based therapy has the potential for immunomodulation and enhancement of tissue regeneration. Genetically modified MSCs that over-express specific cytokines, growth factors, or chemo...

    Authors: Ning Zhang, Chi-Wen Lo, Takeshi Utsunomiya, Masahiro Maruyama, Ejun Huang, Claire Rhee, Qi Gao, Zhenyu Yao and Stuart B. Goodman

    Citation: Stem Cell Research & Therapy 2021 12:40

    Content type: Research

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  6. Botulinum toxin (Botox) injection is in widespread clinical use for the treatment of muscle spasms and tendinopathy but the mechanism of action is poorly understood.

    Authors: Peilin Chen, Ziming Chen, Christopher Mitchell, Junjie Gao, Lianzhi Chen, Allan Wang, Toby Leys, Euphemie Landao-Bassonga, Qiujian Zheng, Tao Wang and Minghao Zheng

    Citation: Stem Cell Research & Therapy 2021 12:38

    Content type: Research

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  7. The spinal cord is part of the central nervous system (CNS) and serves to connect the brain to the peripheral nervous system and peripheral tissues. The cell types that primarily comprise the spinal cord are n...

    Authors: Bin Lv, Xing Zhang, Jishan Yuan, Yongxin Chen, Hua Ding, Xinbing Cao and Anquan Huang

    Citation: Stem Cell Research & Therapy 2021 12:36

    Content type: Review

    Published on:

  8. Periodontitis is a chronic inflammatory disease inducing the absorption of alveolar bone and leading to tooth loss. Human amnion-derived mesenchymal stem cells (HAMSCs) have been used for studying inflammatory...

    Authors: Yuli Wang, Fengyi Lv, Lintong Huang, Hengwei Zhang, Bing Li, Weina Zhou, Xuan Li, Yifei Du, Yongchu Pan and Ruixia Wang

    Citation: Stem Cell Research & Therapy 2021 12:35

    Content type: Research

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  9. Lower back pain is often accredited to loss of intervertebral disc (IVD) height and compromised spine stability as a result of intervertebral disc degeneration (IVDD). We aim to locally use bleomycin to induce...

    Authors: Xiao Yang, Zhiqian Chen, Chen Chen, Chen Han, Yifan Zhou, Xunlin Li, Haijun Tian, Xiaofei Cheng, Kai Zhang, An Qin, Tangjun Zhou and Jie Zhao

    Citation: Stem Cell Research & Therapy 2021 12:34

    Content type: Research

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  10. Our aim was to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI).

    Authors: Runfeng Zhang, Jiang Yu, Ningkun Zhang, Wensong Li, Jisheng Wang, Guocai Cai, Yu Chen, Yong Yang and Zhenhong Liu

    Citation: Stem Cell Research & Therapy 2021 12:33

    Content type: Research

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  11. Fistulas have puzzled us all the time and stem cell therapy for it is still in its infancy. We conducted a meta-analysis and systematic review to evaluate the efficacy of stem cells and its potential mechanism...

    Authors: Yantian Cao, Qi Su, Bangjie Zhang, Fangfang Shen and Shaoshan Li

    Citation: Stem Cell Research & Therapy 2021 12:32

    Content type: Review

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  12. Ulcerative colitis (UC) is a chronic and recurrent disease without satisfactory treatment strategies. Dental pulp stem cell (DPSC) transplantation has been proposed as a potential therapy for UC. This study ai...

    Authors: Ning Li, Yichi Zhang, Narayan Nepal, Guoqing Li, Ningning Yang, Haoyuan Chen, Qiuchi Lin, Xuechun Ji, Sijia Zhang and Shizhu Jin

    Citation: Stem Cell Research & Therapy 2021 12:30

    Content type: Research

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  13. Extracellular vesicles (EVs) and their mimics from mesenchymal stem cells (MSCs) are promising drug carriers to improve cancer treatment, but their application is hindered by donor variations and expansion lim...

    Authors: Qingguo Zhao, Bo Hai, Jack Kelly, Samuel Wu and Fei Liu

    Citation: Stem Cell Research & Therapy 2021 12:29

    Content type: Research

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  14. A skin flap is one of the most critical surgical techniques for the restoration of cutaneous defects. However, the distal necrosis of the skin flap severely restricts the clinical application of flap surgery. ...

    Authors: Yuan Li, Qi-lin Jiang, Leanne Van der Merwe, Dong-hao Lou and Cai Lin

    Citation: Stem Cell Research & Therapy 2021 12:28

    Content type: Review

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  15. The therapeutic effect of mesenchymal stem cells (MSCs) from human adipose tissue on renal interstitial fibrosis has been demonstrated by several groups. However, the way to enhance the renoprotective effect o...

    Authors: Shulin Li, Yanping Wang, Zhuojun Wang, Lu Chen, Bangjie Zuo, Caixia Liu and Dong Sun

    Citation: Stem Cell Research & Therapy 2021 12:27

    Content type: Research

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  16. Bone marrow stromal cells (BMSC) show promise in cartilage repair, and sheep are the most common large animal pre-clinical model.

    Authors: K. Futrega, E. Music, P. G. Robey, S. Gronthos, R. Crawford, S. Saifzadeh, T. J. Klein and M. R. Doran

    Citation: Stem Cell Research & Therapy 2021 12:26

    Content type: Research

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  17. Subretinal fibrosis resulting from neovascular age-related macular degeneration (nAMD) is one of the major causes of serious and irreversible vision loss worldwide, and no definite and effective treatment exis...

    Authors: Dongli Li, Junxiu Zhang, Zijia Liu, Yuanyuan Gong and Zhi Zheng

    Citation: Stem Cell Research & Therapy 2021 12:24

    Content type: Research

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  18. Retinal degenerative diseases remain the dominant causes of blindness worldwide, and cell replacement is viewed as a promising therapeutic direction. However, the resources of seed cells are hard to obtain. To...

    Authors: Yifeng Ke, Xiaoe Fan, Rui Hao, Lijie Dong, Min Xue, Liangzhang Tan, Chunbo Yang, Xiaorong Li and Xinjun Ren

    Citation: Stem Cell Research & Therapy 2021 12:21

    Content type: Research

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    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:134

  19. Spinal cord injury is a devastating clinical condition for which there are currently no effective therapeutic options. In the present study, we aim to investigate if the effect of an administered injection of ...

    Authors: Yong Cao, Yan Xu, Chunyuan Chen, Hui Xie, Hongbin Lu and Jianzhong Hu

    Citation: Stem Cell Research & Therapy 2021 12:20

    Content type: Research

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  20. Radial extracorporeal shockwave (r-ESW), an innovative and noninvasive technique, is gaining increasing attention in regenerative medicine due to its mechanobiological effects. Subchondral bone stem/progenitor...

    Authors: Zhidong Zhao, Yuxing Wang, Qian Wang, Jiawu Liang, Wei Hu, Sen Zhao, Peilin Li, Heng Zhu and Zhongli Li

    Citation: Stem Cell Research & Therapy 2021 12:19

    Content type: Research

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  21. Hematopoietic stem cell (HSC) transplantation is an effective treatment strategy for many types of diseases. Peripheral blood (PB) is the most commonly used source of bone marrow (BM)-derived stem cells for cu...

    Authors: Xiao Fang, Xiong Fang, Yujia Mao, Aaron Ciechanover, Yan Xu, Jing An and Ziwei Huang

    Citation: Stem Cell Research & Therapy 2021 12:17

    Content type: Research

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  22. Our previous studies have proved the efficient exogenous repairing responses via bone marrow stem and progenitor cells (BMSPCs). However, the trafficking of endogenous bone marrow stem and progenitor cells to ...

    Authors: Wenting Gao, Xuetao Yang, Juan Du, Haiyan Wang, Hejiang Zhong, Jianxin Jiang and Ce Yang

    Citation: Stem Cell Research & Therapy 2021 12:16

    Content type: Research

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  23. Acute liver failure (ALF) is an acute inflammatory liver disease with high mortality. Previous preclinical and clinical trials have confirmed that mesenchymal stem cell (MSC) is a promising therapeutic approac...

    Authors: Jinglin Wang, Yang Liu, Haoran Ding, Xiaolei Shi and Haozhen Ren

    Citation: Stem Cell Research & Therapy 2021 12:15

    Content type: Research

    Published on:

  24. Exosomal microRNAs (miRs) derived from mesenchymal stem cells (MSCs) have been shown to play roles in the pathophysiological processes of sepsis. Moreover, miR-27b is highly enriched in MSC-derived exosomes. H...

    Authors: Jia Sun, Xuan Sun, Junhui Chen, Xin Liao, Yixuan He, Jinsong Wang, Rui Chen, Sean Hu and Chen Qiu

    Citation: Stem Cell Research & Therapy 2021 12:14

    Content type: Research

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  25. Dystrophinopathy, a common neuromuscular disorder caused by the absence of dystrophin, currently lacks effective treatments. Systemic transplantation of adipose-derived stem cells (ADSCs) is a promising treatm...

    Authors: Liang Wang, Huan Li, Jinfu Lin, Ruojie He, Menglong Chen, Yu Zhang, Ziyu Liao and Cheng Zhang

    Citation: Stem Cell Research & Therapy 2021 12:12

    Content type: Research

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  26. Mesenchymal stromal cells (MSCs) have been introduced as promising cell source for regenerative medicine. Besides their multilineage differentiation capacity, MSCs release a wide spectrum of bioactive factors....

    Authors: Sebastian Wangler, Amir Kamali, Christina Wapp, Karin Wuertz-Kozak, Sonja Häckel, Claudia Fortes, Lorin M. Benneker, Lisbet Haglund, R. Geoff Richards, Mauro Alini, Marianna Peroglio and Sibylle Grad

    Citation: Stem Cell Research & Therapy 2021 12:11

    Content type: Research

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  27. Spinal cord injury (SCI) presents a significant challenge for the field of neurotherapeutics. Stem cells have shown promise in replenishing the cells lost to the injury process, but the release of axon growth-...

    Authors: Benjamin Jevans, Nicholas D. James, Emily Burnside, Conor J. McCann, Nikhil Thapar, Elizabeth J. Bradbury and Alan J. Burns

    Citation: Stem Cell Research & Therapy 2021 12:10

    Content type: Research

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  28. Abnormalities in apoptosis, cell cycle, proliferation, and differentiation of human bone marrow mesenchymal stem cells (hBMSCs) significantly impact bone metabolism and remodeling, resulting in various skeleta...

    Authors: Tao Li, Yingxing Xu, Yingzhen Wang and Yaping Jiang

    Citation: Stem Cell Research & Therapy 2021 12:9

    Content type: Research

    Published on:

  29. Recent developments in adipose-derived stromal/stem cell (ADSC) biology provide new hopes for tissue engineering and regeneration medicine. Due to their pluripotent activity, paracrine activity, and immunomodu...

    Authors: Jun Fang, Feng Chen, Dong Liu, Feiying Gu and Yuezhen Wang

    Citation: Stem Cell Research & Therapy 2021 12:8

    Content type: Review

    Published on:

  30. The impressive progress in the field of stem cell research in the past decades has provided the ground for the development of cell-based therapy. Mesenchymal stromal cells obtained from adipose tissue (AD-MSCs...

    Authors: Daisy D. Canepa, Elisa A. Casanova, Eirini Arvaniti, Vinko Tosevski, Sonja Märsmann, Benjamin Eggerschwiler, Sascha Halvachizadeh, Johanna Buschmann, André A. Barth, Jan A. Plock, Manfred Claassen, Hans-Christoph Pape and Paolo Cinelli

    Citation: Stem Cell Research & Therapy 2021 12:7

    Content type: Research

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  31. Multipotent progenitor cells have been harvested from different human tissues, including the bone marrow, adipose tissue, and umbilical cord blood. Previously, we identified a population of mesenchymal progeni...

    Authors: Marvin Dingle, Stephen D. Fernicola, Jaira F. de Vasconcellos, Sonia Zicari, Christopher Daniels, John C. Dunn, Alexander Dimtchev and Leon J. Nesti

    Citation: Stem Cell Research & Therapy 2021 12:6

    Content type: Research

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  32. Parkinson’s disease (PD), the second most common neurodegenerative disease worldwide, is caused by the loss of dopaminergic (DAergic) neurons in the substantia nigra resulting in a series of motor or non-motor...

    Authors: Zhuangzhuang Xiao, Tong Lei, Yanyan Liu, Yanjie Yang, Wangyu Bi and Hongwu Du

    Citation: Stem Cell Research & Therapy 2021 12:5

    Content type: Review

    Published on:

  33. As one of the main functional forms of mesenchymal stem cells (MSCs), MSC-derived extracellular vesicles (MSC-EVs) have shown an alternative therapeutic option in experimental models of allergic asthma. Oxygen...

    Authors: Liyang Dong, Ying Wang, Tingting Zheng, Yanan Pu, Yongbin Ma, Xin Qi, Wenzhe Zhang, Fei Xue, Zirui Shan, Jiameng Liu, Xuefeng Wang and Chaoming Mao

    Citation: Stem Cell Research & Therapy 2021 12:4

    Content type: Research

    Published on:

  34. Although pancreatic islet transplantation therapy is ideal for diabetes patients, several hurdles have prevented it from becoming a standard treatment, including donor shortage and low engraftment efficacy. In...

    Authors: Yu Na Lee, Hye-Jin Yi, Eun Hye Seo, Jooyun Oh, Song Lee, Sarah Ferber, Teruo Okano, In Kyong Shim and Song Cheol Kim

    Citation: Stem Cell Research & Therapy 2021 12:3

    Content type: Research

    Published on:

  35. Cerebral infarction ranks as the second leading cause of disability and death globally, and inflammatory response of glial cells is the main cause of brain damage during cerebral infarction.

    Authors: Guofeng Cai, Guoliang Cai, Haichun Zhou, Zhe Zhuang, Kai Liu, Siying Pei, Yanan Wang, Hong Wang, Xin Wang, Shengnan Xu, Cheng Cui, Manchao Sun, Sihui Guo, Kunping Jia, Xiuzhen Wang and Dianquan Zhang

    Citation: Stem Cell Research & Therapy 2021 12:2

    Content type: Research

    Published on:

  36. Adipose-derived stem cells (ADSCs) have raised big interest in therapeutic applications in regenerative medicine and appear to fulfill the criteria for a successful cell therapy. Their low immunogenicity and t...

    Authors: Loubna Mazini, Mohamed Ezzoubi and Gabriel Malka

    Citation: Stem Cell Research & Therapy 2021 12:1

    Content type: Review

    Published on:

  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Selami Demirci, Juan J. Haro-Mora, Alexis Leonard, Claire Drysdale, Daniela Malide, Keyvan Keyvanfar, Khaled Essawi, Raul Vizcardo, Naritaka Tamaoki, Nicholas P. Restifo, John F. Tisdale and Naoya Uchida

    Citation: Stem Cell Research & Therapy 2020 11:544

    Content type: Correction

    Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:493

  38. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Behnaz Ashtari, Azar Shams, Narges Esmaeilzadeh, Sara Tanbakooei, Morteza Koruji, Mojtaba Johari Moghadam, Javad Mohajer Ansari, Adel Johari Moghadam and Ronak Shabani

    Citation: Stem Cell Research & Therapy 2020 11:543

    Content type: Correction

    Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:191

  39. Stem cell transplantation of exogenous neural progenitor cells (NPCs) derived from mesenchymal stem cells (MSCs) has emerged as a promising approach for neurodegenerative disease. Human stem cells from apical ...

    Authors: Anupong Songsaad, Thanasup Gonmanee, Nisarat Ruangsawasdi, Chareerut Phruksaniyom and Charoensri Thonabulsombat

    Citation: Stem Cell Research & Therapy 2020 11:542

    Content type: Research

    Published on:

  40. Mesenchymal stem cells (MSCs) have exerted their brilliant potential to promote heart repair following myocardial infarction. However, low survival rate of MSCs after transplantation due to harsh conditions wi...

    Authors: Jiaying Fu, Xuxiang Chen, Xin Liu, Daishi Xu, Huan Yang, Chaotao Zeng, Huibao Long, Changqing Zhou, Haidong Wu, Guanghui Zheng, Hao Wu, Wuming Wang and Tong Wang

    Citation: Stem Cell Research & Therapy 2020 11:541

    Content type: Research

    Published on:

  41. The effects of cryopreservation on human bone marrow-derived mesenchymal stem cells (hBM-MSCs) are still ill-defined. In this study, a quantitative approach was adopted to measure several post-thaw cell attrib...

    Authors: Soukaina Bahsoun, Karen Coopman and Elizabeth C. Akam

    Citation: Stem Cell Research & Therapy 2020 11:540

    Content type: Research

    Published on:

  42. The paracrine effects of multipotent mesenchymal stromal cells (MSCs) are mediated by their secretome composed by soluble factors (i.e., cytokines, growth factors, hormones) and extracellular vesicles (EVs). E...

    Authors: Anastasia Cheng, Dongsic Choi, Maximilien Lora, Dominique Shum-Tim, Janusz Rak and Inés Colmegna

    Citation: Stem Cell Research & Therapy 2020 11:539

    Content type: Research

    Published on:

  43. Arteriosclerosis is an age-related disease and a leading cause of cardiovascular disease. In animal experiments, mesenchymal stem cells and its culture-conditioned medium have been shown to be promising tools ...

    Authors: Hiroki Ohta, Xiaolan Liu and Miho Maeda

    Citation: Stem Cell Research & Therapy 2020 11:538

    Content type: Research

    Published on:

  44. The role of bone tissue engineering is to regenerate tissue using biomaterials and stem cell-based approaches. Combination of two or more cell types is one of the strategies to promote bone formation. Endothel...

    Authors: Chu Xu, Haijie Liu, Yuanjia He, Yuanqing Li and Xiaoning He

    Citation: Stem Cell Research & Therapy 2020 11:537

    Content type: Research

    Published on:

  45. Skeletal muscle is a complex and heterogeneous tissue accounting for approximately 40% of body weight. Excessive ectopic lipid accumulation in the muscle fascicle would undermine the integrity of skeletal musc...

    Authors: Xin Zhang, Wenjuan Sun, Linjuan He, Liqi Wang, Kai Qiu and Jingdong Yin

    Citation: Stem Cell Research & Therapy 2020 11:536

    Content type: Research

    Published on:

  46. Tissue engineering is a promising alternative for urethral reconstruction, and adipose-derived stem cells (ADSCs) are widely used as seeding cells. Hypoxia preconditioning can significantly enhance the therape...

    Authors: Xiang Wan, Min-kai Xie, Huan Xu, Zi-wei Wei, Hai-jun Yao, Zhong Wang and Da-chao Zheng

    Citation: Stem Cell Research & Therapy 2020 11:535

    Content type: Research

    Published on:

  47. Mesenchymal stem/stromal cells can modulate the effector immune cells especially T lymphocytes. Due to this important feature, they can regulate the development of a variety of disorders including inflammatory...

    Authors: Sina Naserian, Sara Shamdani, Nassim Arouche and Georges Uzan

    Citation: Stem Cell Research & Therapy 2020 11:534

    Content type: Short report

    Published on:

  48. Biological composite scaffolds are increasingly being used in abdominal wall reconstruction but still have certain shortcomings. The present study describes here a novel three-dimensional (3D) scaffold fabrica...

    Authors: Zhi Yang, Zhicheng Song, Xin Nie, Kaijin Guo and Yan Gu

    Citation: Stem Cell Research & Therapy 2020 11:533

    Content type: Research

    Published on:

  49. Human mesenchymal stromal cells (MSC) hold hopes for cartilage regenerative therapy due to their chondrogenic differentiation potential. However, undesirable occurrence of calcification after ectopic transplan...

    Authors: Svitlana Melnik, Jessica Gabler, Simon I. Dreher, Nicole Hecht, Nina Hofmann, Tobias Großner and Wiltrud Richter

    Citation: Stem Cell Research & Therapy 2020 11:532

    Content type: Research

    Published on:

  50. The transplantation of human umbilical cord blood (UCB) CD34+ cells has been successfully used to treat hematological disorders but one major limitation has been the low cell numbers available. Mesenchymal ste...

    Authors: Hao Daniel Lin, Chui-Yee Fong, Arijit Biswas and Ariff Bongso

    Citation: Stem Cell Research & Therapy 2020 11:527

    Content type: Research

    Published on:

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