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  1. Content type: Review

    Osteonecrosis of the femoral head (ONFH) is a refractory disease that is associated with collapse of the femoral head, with a risk of hip arthroplasty in younger populations. Thus, there has been an increased ...

    Authors: Rui Li, Qiu-Xia Lin, Xue-Zhen Liang, Guang-Bo Liu, He Tang, Yu Wang, Shi-Bi Lu and Jiang Peng

    Citation: Stem Cell Research & Therapy 2018 9:291

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  3. Content type: Research

    Stem cells have great potential for tissue regeneration, but before stem cell populations can be used in the clinic, it is crucial that the stem cells have been definitely characterized by a set of specific ma...

    Authors: Louise Bundgaard, Allan Stensballe, Kirstine Juul Elbæk and Lise Charlotte Berg

    Citation: Stem Cell Research & Therapy 2018 9:288

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  4. Content type: Review

    Human-induced pluripotent stem cells (hiPSCs) provide a personalized approach to study conditions and diseases including those of the eye that lack appropriate animal models to facilitate the development of no...

    Authors: Koushik Chakrabarty, Rohit Shetty and Arkasubhra Ghosh

    Citation: Stem Cell Research & Therapy 2018 9:287

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  5. Content type: Research

    Diabetic peripheral neurovascular diseases (DPNVs) are complex, lacking effective treatment. Autologous/allogeneic transplantation of adipose-derived stem cells (ADSCs) is a promising strategy for DPNVs. Nonet...

    Authors: Xing Zhang, Jinbao Qin, Xin Wang, Xin Guo, Junchao Liu, Xuhui Wang, Xiaoyu Wu, Xinwu Lu, Weimin Li and Xiaobing Liu

    Citation: Stem Cell Research & Therapy 2018 9:285

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  6. Content type: Research

    Treatment with bone marrow mesenchymal stem cells (BM-MSCs) has been demonstrated to be an excellent cellular-based therapeutic strategy for treating myocardial infarction (MI). However, most of the patients s...

    Authors: Ming Yang, Tong Wen, Haixu Chen, Jingyu Deng, Chao Yang and Zheng Zhang

    Citation: Stem Cell Research & Therapy 2018 9:284

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  7. Content type: Research

    Conventional cell-based bone regeneration suffers from the major disadvantage of limited cell supply, time-consuming in vitro expansion cultures, and limited patient-friendliness related to cell isolation and ...

    Authors: Yang Zhang, Eline C Grosfeld, Winston A Camargo, Hongbo Tang, Angela M P Magri and Jeroen J J P van den Beucken

    Citation: Stem Cell Research & Therapy 2018 9:283

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  8. Content type: Research

    Severe acute pancreatitis (SAP) is an acute abdominal disease characterized by pancreatic necrosis and systemic disease. In a previous study, we showed that bone marrow-derived mesenchymal stem cells (BMSCs) c...

    Authors: Daohai Qian, Guodong Song, Zhilong Ma, Guannan Wang, Lei Jin, Minghua Hu, Zhenshun Song and Xiaoming Wang

    Citation: Stem Cell Research & Therapy 2018 9:282

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  9. Content type: Research

    Mesenchymal stem cells (MSCs) are known to home to injured and inflamed regions via the bloodstream to assist in tissue regeneration in response to signals of cellular damage. However, the factors and mechanis...

    Authors: Yu-Chien Guo, Yun-Hsuan Chiu, Chie-Pein Chen and Hwai-Shi Wang

    Citation: Stem Cell Research & Therapy 2018 9:281

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  10. Content type: Research

    Mesenchymal stem cells (MSCs) derived from bone marrow have potent stabilizing effects for the treatment of acute respiratory distress syndrome (ARDS). However, low efficiency and survival in MSC homing to inj...

    Authors: Shan-Shan Meng, Xiu-Ping Xu, Wei Chang, Zhong-Hua Lu, Li-Li Huang, Jing-Yuan Xu, Ling Liu, Hai-Bo Qiu, Yi Yang and Feng-Mei Guo

    Citation: Stem Cell Research & Therapy 2018 9:280

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  11. Content type: Research

    Generation of induced photoreceptors holds promise for in vitro modeling of intractable retinal diseases. Retinitis pigmentosa is an inherited retinal dystrophy that leads to visual impairment. The EYS gene was r...

    Authors: Yuko Seko, Masaki Iwanami, Kiyoko Miyamoto-Matsui, Shimpei Takita, Noriyuki Aoi, Akihiro Umezawa and Seishi Kato

    Citation: Stem Cell Research & Therapy 2018 9:279

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  12. Content type: Research

    Mesenchymal stem cells (MSCs) isolated from adult tissues (Ad-MSCs) have shown great promise for use in regenerative medicine. However, their poor in vitro expansion capacity and tissue scarcity have been majo...

    Authors: William D’Angelo, Bohan Chen, Chandan Gurung and Yan-Lin Guo

    Citation: Stem Cell Research & Therapy 2018 9:278

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  13. Content type: Research

    Transplantation of pancreatic β cells generated in vitro from pluripotent stem cells (hPSCs) such as embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) has been proposed as an alternative th...

    Authors: Hideomi Ida, Tomohiko Akiyama, Keiichiro Ishiguro, Sravan K. Goparaju, Yuhki Nakatake, Nana Chikazawa-Nohtomi, Saeko Sato, Hiromi Kimura, Yukihiro Yokoyama, Masato Nagino, Minoru S. H. Ko and Shigeru B. H. Ko

    Citation: Stem Cell Research & Therapy 2018 9:277

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  14. Content type: Research

    Physical loading is necessary to maintain bone tissue integrity. Loading-induced fluid shear is recognised as one of the most potent bone micromechanical cues and has been shown to direct stem cell osteogenesi...

    Authors: Elena Stavenschi, Michele A. Corrigan, Gillian P. Johnson, Mathieu Riffault and David A. Hoey

    Citation: Stem Cell Research & Therapy 2018 9:276

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  15. Content type: Research

    Mesenchymal stromal cells (MSCs) are an essential element of the bone marrow (BM) microenvironment, playing a crucial function in regulating hematopoietic stem cell proliferation and differentiation. Recent fi...

    Authors: Giulia Corradi, Carmen Baldazzi, Darina Očadlíková, Giovanni Marconi, Sarah Parisi, Nicoletta Testoni, Carlo Finelli, Michele Cavo, Antonio Curti and Marilena Ciciarello

    Citation: Stem Cell Research & Therapy 2018 9:271

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  16. Content type: Research

    Efficient and sustained hematopoietic recovery after hematopoietic stem cell or bone marrow transplantation is supported by paracrine signaling from specific subpopulations of mesenchymal stromal cells (MSCs)....

    Authors: Frances D. Liu, Kimberley Tam, Novalia Pishesha, Zhiyong Poon and Krystyn J. Van Vliet

    Citation: Stem Cell Research & Therapy 2018 9:268

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  18. Content type: Research

    Adipose derived stem cells can be stimulated to produce a growth factor rich secretome which enhances axon regeneration. In this study we investigated the importance of exosomes, extracellular vesicles release...

    Authors: Rosanna C Ching, Mikael Wiberg and Paul J Kingham

    Citation: Stem Cell Research & Therapy 2018 9:266

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  19. Content type: Research

    In the bone marrow, MSCs reside in a hypoxic milieu (1–5% O2) that is thought to preserve their multipotent state. Typically, in vitro expansion of MSCs is performed under normoxia (~ 21% O2), a process that has ...

    Authors: Ben Antebi, Luis A Rodriguez II, Kerfoot P Walker III, Amber M Asher, Robin M Kamucheka, Lucero Alvarado, Arezoo Mohammadipoor and Leopoldo C Cancio

    Citation: Stem Cell Research & Therapy 2018 9:265

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  20. Content type: Correction

    The original article [1] contains a number of small errors which the authors would like to clarify:

    Authors: Bushra Memon, Manale Karam, Sara Al-Khawaga and Essam M. Abdelalim

    Citation: Stem Cell Research & Therapy 2018 9:262

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    The original article was published in Stem Cell Research & Therapy 2018 9:15

  21. Content type: Correction

    The original article [1] contains numerous value errors in the graphs in Fig. 2b regarding the markers describing the values for total tubule length and mean tubule length without aprotinin at 2.5 mg/ml concen...

    Authors: Severin Mühleder, Karoline Pill, Mira Schaupper, Krystyna Labuda, Eleni Priglinger, Pablo Hofbauer, Verena Charwat, Uwe Marx, Heinz Redl and Wolfgang Holnthoner

    Citation: Stem Cell Research & Therapy 2018 9:261

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    The original article was published in Stem Cell Research & Therapy 2018 9:35

  22. Content type: Correction

    The original article [1] contains a major error carried across the captions of Tables 1, 2, and 3. In each table caption, the data were expressed as “mean ± standard deviation (SD)”; unfortunately, the authors...

    Authors: Fa-Ming Chen, Li-Na Gao, Bei-Min Tian, Xi-Yu Zhang, Yong-Jie Zhang, Guang-Ying Dong, Hong Lu, Qing Chu, Jie Xu, Yang Yu, Rui-Xin Wu, Yuan Yin, Songtao Shi and Yan Jin

    Citation: Stem Cell Research & Therapy 2018 9:260

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    The original article was published in Stem Cell Research & Therapy 2016 7:33

  23. Content type: Correction

    The original article [1] contained a minor error regarding the mean diameter of the alginate microcapsules described in relation to Fig. 4 in the Results section. The microcapsules had an actual mean diameter ...

    Authors: Vitor Hugo Santos, João Pedro Hübbe Pfeifer, Jaqueline Brandão de Souza, Betsabéia Heloisa Gentilha Milani, Rogério Antonio de Oliveira, Marjorie Golim Assis, Elenice Deffune, Andrei Moroz and Ana Liz Garcia Alves

    Citation: Stem Cell Research & Therapy 2018 9:259

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    The original article was published in BMC Veterinary Research 2018 14:114

  24. Content type: Short report

    Normal human breast epithelial cells are maintained by the proliferation and differentiation of different human breast epithelial progenitors (HBEPs). However, these progenitor subsets can only be obtained at ...

    Authors: Sumanta Chatterjee, Pratima Basak, Edward Buchel, Leigh C. Murphy and Afshin Raouf

    Citation: Stem Cell Research & Therapy 2018 9:264

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  25. Content type: Review

    With the development of regenerative medicine, a variety of mesenchymal stem cells (MSCs) are increasingly considered for the treatment of premature ovarian failure (POF). Reportedly, bone marrow-derived MSCs ...

    Authors: Yantao He, Dongmei Chen, Lingling Yang, Qiaoni Hou, Huiming Ma and Xian Xu

    Citation: Stem Cell Research & Therapy 2018 9:263

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  26. Content type: Research

    Skeletal muscle regeneration is possible thanks to unipotent stem cells, which are satellite cells connected to the myofibers. Populations of stem cells other than muscle-specific satellite cells are considere...

    Authors: Kamil Kowalski, Matthieu Dos Santos, Pascal Maire, Maria A. Ciemerych and Edyta Brzoska

    Citation: Stem Cell Research & Therapy 2018 9:258

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  27. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease for which age is the most important risk factor. Different mechanisms associated with aging, including stem cell dysfunction, have been described t...

    Authors: Nayra Cárdenes, Diana Álvarez, Jacobo Sellarés, Yating Peng, Catherine Corey, Sophie Wecht, Seyed Mehdi Nouraie, Swaroop Shanker, John Sembrat, Marta Bueno, Sruti Shiva, Ana L. Mora and Mauricio Rojas

    Citation: Stem Cell Research & Therapy 2018 9:257

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  28. Content type: Research

    Cultivated oral mucosal epithelial cells (OMECs) are widely used in the treatment of limbal stem cell deficiency (LSCD) for their ocular reconstruction capability. As the most important component of the limbal...

    Authors: Xin-Yue Zhao, Hua-Tao Xie, Chao-Ye Duan, Jing Li and Ming-Chang Zhang

    Citation: Stem Cell Research & Therapy 2018 9:256

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    The Correction to this article has been published in Stem Cell Research & Therapy 2018 9:270

  29. Content type: Research

    Through recent studies, the onset of acute pancreatitis in pancreatic acinar cells (PACs) and the regulatory role of PACs in severe acute pancreatitis (SAP) have been revealed. During the early stages of pancr...

    Authors: Qiang Li, Woo-Jin Song, Min-Ok Ryu, Aryung Nam, Ju-Hyun An, Jin-Ok Ahn, Dong Ha Bhang, Yun Chan Jung and Hwa-Young Youn

    Citation: Stem Cell Research & Therapy 2018 9:255

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  30. Content type: Review

    Inducing donor-specific immunological tolerance, which avoids the complications of long-term immunosuppression, is an important goal in organ transplantation. Interleukin-35 (IL-35), a cytokine identified in 2...

    Authors: Hao Guo, Baozhu Li, Wei Wang, Na Zhao and Haopeng Gao

    Citation: Stem Cell Research & Therapy 2018 9:254

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  31. Content type: Research

    Bone marrow mesenchymal stem cells (BMSC) transfer has been attempted as a therapeutic strategy in experimental lung injury and fibrosis. Reduction of neutrophilic infiltration is one of the mechanisms involve...

    Authors: XiaoSan Su, Liu Yang, YanFeng Yin, Jie Huang, Fei Qiao, Yu Fang, Lu Yu, YinYin Wang, KaiHua Zhou and Jun Wang

    Citation: Stem Cell Research & Therapy 2018 9:253

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  32. Content type: Research

    The increasing number of patients with ovarian insufficiency due to autoimmune disorders, genetic predisposition, or iatrogenic effects of treatment such as cancer therapies necessitates an urgent measure to f...

    Authors: Ashraf Hassanpour, Tahereh Talaei-Khozani, Elias Kargar-Abarghouei, Vahid Razban and Zahra Vojdani

    Citation: Stem Cell Research & Therapy 2018 9:252

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  33. Content type: Research

    It is known that, following a physiological insult, bone marrow-derived mesenchymal stem cells (MSCs) mobilize and home to the site of injury. However, the effect of injury on the function of endogenous MSCs i...

    Authors: Ben Antebi, Kerfoot P. Walker III, Arezoo Mohammadipoor, Luis A. Rodriguez, Robbie K. Montgomery, Andriy I. Batchinsky and Leopoldo C. Cancio

    Citation: Stem Cell Research & Therapy 2018 9:251

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  34. Content type: Research

    Cell therapy for degenerative diseases aims at rescuing tissue damage by delivery of precursor cells. Thus far, this strategy has been mostly unsuccessful due to massive loss of donor cells shortly after trans...

    Authors: Giuliana Di Rocco, Silvia Baldari, Antonietta Gentile, Maurizio Capogrossi and Gabriele Toietta

    Citation: Stem Cell Research & Therapy 2018 9:250

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  35. Content type: Research

    In-vitro spermatogenesis in mammalian species is considered an important topic in reproductive biology. New strategies for achieving a complete version of spermatogenesis ex vivo have been conducted using an o...

    Authors: Keykavos Gholami, Gholamreza Pourmand, Morteza Koruji, Sepideh Ashouri and Mehdi Abbasi

    Citation: Stem Cell Research & Therapy 2018 9:249

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  36. Content type: Research

    Stem cells are increasingly seen as a solution for many health challenges for an ageing population. However, their potential benefits in the clinic are currently curtailed by technical challenges such as high ...

    Authors: Richard Harrison, Hilda Anaid Lugo Leija, Stephanie Strohbuecker, James Crutchley, Sarah Marsh, Chris Denning, Alicia El Haj and Virginie Sottile

    Citation: Stem Cell Research & Therapy 2018 9:248

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  37. Content type: Research

    WNT5A is known to be involved in the pathogenesis of osteoarthritis. This study investigated the molecular mechanism of exosomal miR-92a-3p and WNT5A in chondrogenesis and cartilage degeneration.

    Authors: Guping Mao, Ziji Zhang, Shu Hu, Zhiqi Zhang, Zongkun Chang, Zhiyu Huang, Weiming Liao and Yan Kang

    Citation: Stem Cell Research & Therapy 2018 9:247

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  38. Content type: Research

    This study investigated the therapeutic effects of MSC-derived exosomes (MSC-Exos) on erectile function in a rat model of cavernous nerve injury (CNI).

    Authors: Xi Ouyang, Xiaoyan Han, Zehong Chen, Jiafeng Fang, Xuna Huang and Hongbo Wei

    Citation: Stem Cell Research & Therapy 2018 9:246

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  39. Content type: Review

    Neurodegenerative disorders have a complex pathology and are characterized by a progressive loss of neuronal architecture in the brain or spinal cord. Neuroprotective agents have demonstrated promising results...

    Authors: Syed Shadab Raza, Aurel Popa Wagner, Yawer S. Hussain and Mohsin Ali Khan

    Citation: Stem Cell Research & Therapy 2018 9:245

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  40. Content type: Review

    Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related progressive disease characterized by reduced bone mass and increased risk of fractures. At the cellular level, the ...

    Authors: Arantza Infante and Clara I. Rodríguez

    Citation: Stem Cell Research & Therapy 2018 9:244

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  41. Content type: Method

    Non-adherent or ultra-low attachment three-dimensional (3D) culture, also called sphere formation assay, has been widely used to assess the malignant phenotype and stemness potential of transformed or cancer c...

    Authors: Weijie Gao, Dinglan Wu, Yuliang Wang, Zhu Wang, Chang Zou, Yong Dai, Chi-Fai Ng, Jeremy Yuen-Chun Teoh and Franky Leung Chan

    Citation: Stem Cell Research & Therapy 2018 9:243

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  42. Content type: Research

    Androgen deprivation (AD) as the first-line treatment for advanced prostate cancer (PCa) is insufficient for a long-term effect. Castration resistance remains the greatest obstacle in PCa clinical therapy. Mes...

    Authors: Yang Yu, Qingyun Zhang, Chengzhong Ma, Xue Yang, Rui Lin, Hongxiang Zhang, Yan Liu, Zhipeng Han and Jiwen Cheng

    Citation: Stem Cell Research & Therapy 2018 9:242

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  43. Content type: Commentary

    Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disease with no cure or treatment to stop disease progression. Because ALS represents an urgent unmet medical need, a significant number of therapeutics...

    Authors: Luis Barbeito

    Citation: Stem Cell Research & Therapy 2018 9:241

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    The original article was published in Stem Cell Research & Therapy 2018 9:152

  44. Content type: Research

    Premature ovarian failure (POF) is a severe complication associated with chemotherapy for female patients of childbearing age. A previous study has shown that bone marrow-derived mesenchymal stem cells (MSCs) ...

    Authors: Xiaoying Chen, Qing Wang, Xinran Li, Qingru Wang, Jiaxin Xie and Xiafei Fu

    Citation: Stem Cell Research & Therapy 2018 9:240

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  45. Content type: Research

    Cell therapy constitutes an attractive alternative to treat stress urinary incontinence. Although promising results have been demonstrated in this field, the procedure requires further optimization. The most c...

    Authors: Anna Burdzinska, Bartosz Dybowski, Weronika Zarychta-Wiśniewska, Agnieszka Kulesza, Marta Butrym, Radoslaw Zagozdzon, Agnieszka Graczyk-Jarzynka, Piotr Radziszewski, Zdzislaw Gajewski and Leszek Paczek

    Citation: Stem Cell Research & Therapy 2018 9:239

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  46. Content type: Research

    Mesenchymal stem/stromal cells derived from chorionic villi of human term placentae (pMSCs) protect human endothelial cells from injury induced by hydrogen peroxide (H2O2). In diabetes, elevated levels of glucose...

    Authors: Y. S. Basmaeil, A. M. Al Subayyil, T. Khatlani, E. Bahattab, M. Al-Alwan, F. M. Abomaray, B. Kalionis, M. A. Alshabibi, A. S. AlAskar and M. H. Abumaree

    Citation: Stem Cell Research & Therapy 2018 9:238

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  47. Content type: Research

    Mesenchymal stem cells (MSCs) play an anti-inflammatory role by secreting certain bioactive molecules to exert their therapeutic effects for disease treatment. However, the underlying mechanism of MSCs in chro...

    Authors: Junyu Fan, Xiaojun Tang, Qian Wang, Zhuoya Zhang, Shufang Wu, Wenchao Li, Shanshan Liu, Genhong Yao, Hongwei Chen and Lingyun Sun

    Citation: Stem Cell Research & Therapy 2018 9:237

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  48. Content type: Review

    In this review we present current evidence on the possibility of umbilical cord tissue cryopreservation for subsequent clinical use. Protocols for obtaining umbilical cord-derived vessels, Wharton’s jelly-base...

    Authors: Irina Arutyunyan, Timur Fatkhudinov and Gennady Sukhikh

    Citation: Stem Cell Research & Therapy 2018 9:236

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  49. Content type: Research

    Cell therapy with bone marrow (BM)-derived progenitors has emerged as a promising therapeutic for refractory angina (RA) patients. In the present study, we evaluated the safety and preliminary efficacy of tran...

    Authors: Beatrice Bassetti, Corrado Carbucicchio, Valentina Catto, Elisa Gambini, Erica Rurali, Alberto Bestetti, Giuseppe Gaipa, Daniela Belotti, Fabrizio Celeste, Matteo Parma, Stefano Righetti, Lorenza Biava, Maurizio Arosio, Alice Bonomi, Piergiuseppe Agostoni, Paolo Scacciatella…

    Citation: Stem Cell Research & Therapy 2018 9:235

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  50. Content type: Research

    In an earlier pilot study with 10 women, we investigated a new approach for therapy of faecal incontinence (FI) due to obstetric trauma, involving ultrasound-guided injection of autologous skeletal muscle-deri...

    Authors: Andrea Frudinger, Rainer Marksteiner, Johann Pfeifer, Eva Margreiter, Johannes Paede and Marco Thurner

    Citation: Stem Cell Research & Therapy 2018 9:233

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Stem Cell Research & Therapy

ISSN: 1757-6512