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  1. Direct bone marrow injection of cells into murine marrow cavities is used in a range of cell characterization assays and to develop disease models. While human bone marrow-derived stromal cells (hBMSC, also kn...

    Authors: Bianca Nowlan, Kathryn Futrega, Elizabeth Deborah Williams and Michael Robert Doran

    Citation: Stem Cell Research & Therapy 2021 12:231

    Content type: Research

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  2. Pulmonary fibrosis (PF), the end point of interstitial lung diseases, is characterized by myofibroblast over differentiation and excessive extracellular matrix accumulation, leading to progressive organ dysfun...

    Authors: Liyan Shi, Jing Ren, Jiping Li, Dongxu Wang, Yusu Wang, Tao Qin, Xiuying Li, Guokun Zhang, Chunyi Li and Yimin Wang

    Citation: Stem Cell Research & Therapy 2021 12:230

    Content type: Research

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  3. Stem cells have been introduced as new promising therapeutic agents in treatment of degenerative diseases because of having high differentiation potential while maintaining the ability to self-replicate and re...

    Authors: Rano Zhankina, Neda Baghban, Manarbek Askarov, Dana Saipiyeva, Almaz Ibragimov, Bakhyt Kadirova, Arezoo Khoradmehr, Iraj Nabipour, Reza Shirazi, Ulanbek Zhanbyrbekuly and Amin Tamadon

    Citation: Stem Cell Research & Therapy 2021 12:229

    Content type: Review

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  4. Adult mesenchymal stem cells (MSCs) have been studied extensively for regenerative medicine; however, they have limited proliferation in vitro, and the long culture time induces cell senescence. MSCs also cont...

    Authors: Guobing Zhuang, Yan Wen, Mason Briggs, Qingchun Shao, Darlene Tran, Hongbo Wang and Bertha Chen

    Citation: Stem Cell Research & Therapy 2021 12:228

    Content type: Research

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  5. Systemic administration of mesenchymal stromal cells (MSCs) has been efficacious in many inflammatory disease settings; however, little data are available on the potential immunomodulatory effects following lo...

    Authors: Oliver Treacy, Kevin Lynch, Nick Murphy, Xizhe Chen, Ellen Donohoe, Aoife Canning, Paul Lohan, Georgina Shaw, Gerry Fahy, Aideen E. Ryan and Thomas Ritter

    Citation: Stem Cell Research & Therapy 2021 12:227

    Content type: Short report

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  6. Wound healing is impaired in patients with diabetes due to the multifactorial etiology of the disease, which limits the therapeutic efficacy of various approaches. This study hypothesizes that the combination ...

    Authors: Xuejun Ni, Xiuying Shan, Lili Xu, Wenjun Yu, Mingliang Zhang, Chen Lei, Nating Xu, Junyu Lin and Biao Wang

    Citation: Stem Cell Research & Therapy 2021 12:226

    Content type: Research

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  7. Premature exfoliation of the deciduous teeth is a common manifestation in childhood patients with hypophosphatasia (HPP), which is an autosomal inherited disease caused by ALPL mutations. Dysplasia of the ceme...

    Authors: Liqiang Zhang, Jiangdong Zhao, Jiayi Dong, Yuting Liu, Kun Xuan and Wenjia Liu

    Citation: Stem Cell Research & Therapy 2021 12:225

    Content type: Research

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  8. Exosomes derived from the bone marrow mesenchymal stem cell (MSC) have shown great potential in spinal cord injury (SCI) treatment. This research was designed to investigate the therapeutic effects of miR-26a-...

    Authors: Yuyong Chen, Zhenming Tian, Lei He, Can Liu, Nangxiang Wang, Limin Rong and Bin Liu

    Citation: Stem Cell Research & Therapy 2021 12:224

    Content type: Research

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  9. Human amniotic epithelial cells (hAECs) exhibit a strong capability to restore ovarian function in chemotherapy-induced premature ovarian failure (POF). However, the therapeutic efficacy of hAECs is usually af...

    Authors: Yating Huang, Zhijie Ma, Xiaojun Kuang, Qiuwan Zhang, Haiyan Li and Dongmei Lai

    Citation: Stem Cell Research & Therapy 2021 12:223

    Content type: Research

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  10. To explore the adipogenic effects of the small extracellular vesicles derived from the lipoma tissues (sEV-LT), and to find a new cell-free therapeutic approach for adipose tissue regeneration.

    Authors: Pengyu Hong, Xiaoyang Xu, Xin Hu, Hao Yang, Yue Wu, Juan Chen, Kun Li and Zhangui Tang

    Citation: Stem Cell Research & Therapy 2021 12:222

    Content type: Research

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  11. Hypertrophic scar (HS) is a fibro-proliferative disorder of dermis after burn or trauma and usually leads to esthetic disfiguration and functionary impairment for patients. Emerging evidences demonstrated ADSC...

    Authors: Yan Li, Jian Zhang, Jihong Shi, Kaituo Liu, Xujie Wang, Yanhui Jia, Ting He, Kuo Shen, Yunchuan Wang, Jiaqi Liu, Wei Zhang, Tongtao Wang, Zhao Zheng and Dahai Hu

    Citation: Stem Cell Research & Therapy 2021 12:221

    Content type: Research

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  12. Mesenchymal stem cells (MSCs) exert positive effects in chronic wounds. However, critical parameters, such as the most effective administration routes, remain unclear. Accordingly, the purpose of this study wa...

    Authors: Jianxin Yan, Jiaji Liang, Yingxuan Cao, Mariya M. El Akkawi, Xuan Liao, Xiaojia Chen, Chengzhi Li, Kecheng Li, Guanghui Xie and Hongwei Liu

    Citation: Stem Cell Research & Therapy 2021 12:220

    Content type: Research

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  13. Hepatic ischaemia-reperfusion injury (HIRI) is inevitable in complicated liver surgery and is a major factor leading to postoperative complications and liver dysfunction. Studies have shown that the paracrine ...

    Authors: Zhihui Jiao, Yajun Ma, Qianzhen Zhang, Yue Wang, Tao Liu, Xiaoning Liu, Chenxi Piao, Boyang Liu and Hongbin Wang

    Citation: Stem Cell Research & Therapy 2021 12:218

    Content type: Research

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  14. Despite many recent advances on cancer novel therapies, researchers have yet a long way to cure cancer. They have to deal with tough challenges before they can reach success. Nonetheless, it seems that recentl...

    Authors: Faroogh Marofi, Safa Tahmasebi, Heshu Sulaiman Rahman, Denis Kaigorodov, Alexander Markov, Alexei Valerievich Yumashev, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Rebar N. Mohammed, Mostafa Jarahian, Roza Motavalli and Farhad Motavalli Khiavi

    Citation: Stem Cell Research & Therapy 2021 12:217

    Content type: Review

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  15. Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are syndromes of acute respiratory failure with extremely high mortality and few effective treatments. Mesenchymal stem cells (MSCs) may r...

    Authors: Wenjun Peng, Meijia Chang, Yuanyuan Wu, Wensi Zhu, Lin Tong, Ge Zhang, Qin Wang, Jie Liu, Xiaoping Zhu, Tingting Cheng, Yijia Li, Xi Chen, Dong Weng, Sanhong Liu, Hongwei Zhang, Yao Su…

    Citation: Stem Cell Research & Therapy 2021 12:216

    Content type: Research

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  16. Dysfunction of mesenchymal stem cells (MSCs) is recognized as critical to the pathogenesis of glucocorticoid-induced osteoporosis (GIO), suggesting the potential of MSC-targeting interventions for this disorde...

    Authors: Gang Wang, Fengbin Wang, Lecheng Zhang, Chao Yan and Yuelei Zhang

    Citation: Stem Cell Research & Therapy 2021 12:215

    Content type: Research

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  17. The corneal endothelium maintains corneal hydration through the barrier and pump function, while its dysfunction may cause corneal edema and vision reduction. Considering its development from neural crest cell...

    Authors: Yajie Gong, Haoyun Duan, Xin Wang, Can Zhao, Wenjing Li, Chunxiao Dong, Zongyi Li and Qingjun Zhou

    Citation: Stem Cell Research & Therapy 2021 12:214

    Content type: Research

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  18. Hepatic fibrosis is a common complication in transfusion-dependent thalassemia patients. Data on the co-transplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) in beta-thalassemia...

    Authors: Tahereh Rostami, Amir Kasaeian, Nasrollah Maleki, Mohsen Nikbakht, Azadeh Kiumarsi, Seyed Mohammad Tavangar, Amir Pejman Hashemi Taheri, Seied Asadollah Mousavi and Ardeshir Ghavamzadeh

    Citation: Stem Cell Research & Therapy 2021 12:213

    Content type: Research

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  19. The adoptive transfer of natural killer (NK) cells is an emerging therapy in the field of immuno-oncology. In the last 3 decades, NK cells have been utilized to harness the anti-tumor immune response in a wide...

    Authors: Margaret G. Lamb, Hemalatha G. Rangarajan, Brian P. Tullius and Dean A. Lee

    Citation: Stem Cell Research & Therapy 2021 12:211

    Content type: Review

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  20. Stem cells are characterized by their self-renewal and multipotency and have great potential in the therapy of various disorders. However, the blood–brain barrier (BBB) limits the application of stem cells in ...

    Authors: Yu-Ting Zhang, Kai-Jie He, Jin-Bao Zhang, Quan-Hong Ma, Fen Wang and Chun-Feng Liu

    Citation: Stem Cell Research & Therapy 2021 12:210

    Content type: Review

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  21. Several studies have confirmed that mobilizing bone marrow-derived stem cells (BMSCs) ameliorates renal function loss following cisplatin-induced acute kidney injury (AKI). The aim of this study was to explore...

    Authors: Zhi Chen, Xiang Ren, Ruimin Ren, Yonghong Wang and Jiwen Shang

    Citation: Stem Cell Research & Therapy 2021 12:209

    Content type: Research

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  22. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold great promise for regenerative medicine and in drugs screening. Despite displaying key cardiomyocyte phenotypic characteristics, they...

    Authors: Xinyuan Zhang, Liang Ye, Hao Xu, Qin Zhou, Bin Tan, Qin Yi, Liang Yan, Min Xie, Yin Zhang, Jie Tian and Jing Zhu

    Citation: Stem Cell Research & Therapy 2021 12:208

    Content type: Research

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  23. Cesarean scar defect (CSD) is characterized by the presence of fibrotic tissue and decreased muscular density which is induced by cesarean section. Serious CSD may eventually result in infertility or obstetric...

    Authors: Yihui Fan, Junyan Sun, Qiuwan Zhang and Dongmei Lai

    Citation: Stem Cell Research & Therapy 2021 12:207

    Content type: Research

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  24. Glioblastoma (GBM) is the highest-grade form of glioma, as well as one of the most aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior. Despite significant advances in dia...

    Authors: Ana Laura V. Alves, Izabela N. F. Gomes, Adriana C. Carloni, Marcela N. Rosa, Luciane S. da Silva, Adriane F. Evangelista, Rui Manuel Reis and Viviane Aline O. Silva

    Citation: Stem Cell Research & Therapy 2021 12:206

    Content type: Review

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  25. Immortalized, clonal HB1.​F3.​CD21 human neural stem/progenitor cells (NSCs), loaded with therapeutic cargo prior to intraperitoneal (IP) injection, have been ...

    Authors: Rachael Mooney, Wafa Abidi, Jennifer Batalla-Covello, Hoi Wa Ngai, Caitlyn Hyde, Diana Machado, Asma Abdul-Majid, Yanan Kang, Mohamed Hammad, Linda Flores, Greg Copeland, Thanh Dellinger, Ernest Han, Jacob Berlin and Karen S. Aboody

    Citation: Stem Cell Research & Therapy 2021 12:205

    Content type: Research

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  26. Severe, steroid-resistant asthma (SSRA) is a serious clinical problem in asthma management. Affected patients have severe clinical symptoms, worsened quality of life, and do not respond to steroid, a mainstay ...

    Authors: Bing Dong, Chao Wang, Jing Zhang, Jinrong Zhang, Yinuo Gu, Xiaoping Guo, Xu Zuo, He Pan, Alan Chen-Yu Hsu, Guoqiang Wang and Fang Wang

    Citation: Stem Cell Research & Therapy 2021 12:204

    Content type: Research

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  27. Mesenchymal stem cells (MSCs) provide potential treatments for peritoneal fibrosis. However, MSCs cultured in media containing serum bring risks of infection and other problems. In this study, we compared the ...

    Authors: Kohei Nagasaki, Ayumu Nakashima, Ryo Tamura, Naoki Ishiuchi, Kiyomasa Honda, Toshinori Ueno, Shigehiro Doi, Yukio Kato and Takao Masaki

    Citation: Stem Cell Research & Therapy 2021 12:203

    Content type: Research

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  28. The low survival rate or dysfunction of extracellular matrix (ECM)-based engineered organs caused by the adverse effects of unfavourable local microenvironments on seed cell viability and stemness, especially ...

    Authors: Jiayu Zhang, Tingting Lan, Xue Han, Yuchan Xu, Li Liao, Li Xie, Bo Yang, Weidong Tian and Weihua Guo

    Citation: Stem Cell Research & Therapy 2021 12:202

    Content type: Research

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  29. Cholangiocyte senescence is an important pathological process in diseases such as primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). Stem cell/induced pluripotent stem cell-derived exoso...

    Authors: Wenyi Chen, Jiaqi Zhu, Feiyan Lin, Yanping Xu, Bing Feng, Xudong Feng, Xinyu Sheng, Xiaowei Shi, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Lanjuan Li and Hongcui Cao

    Citation: Stem Cell Research & Therapy 2021 12:201

    Content type: Research

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  30. In recent decades, a new method of cellular immunotherapy was introduced based on engineering and empowering the immune effector cells. In this type of immunotherapy, the immune effector cells are equipped wit...

    Authors: Faroogh Marofi, Heshu Sulaiman Rahman, Lakshmi Thangavelu, Aleksey Dorofeev, Favian Bayas-Morejón, Naghmeh Shirafkan, Navid Shomali, Max Stanley Chartrand, Mostafa Jarahian, Ghasem Vahedi, Rebar N. Mohammed, Somayeh Shahrokh, Morteza Akbari and Farhad Motavalli Khiavi

    Citation: Stem Cell Research & Therapy 2021 12:200

    Content type: Review

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  31. The side effects of busulfan on male reproduction are serious, so fertility preservation in children undergoing busulfan treatment is a major worldwide concern. Human placental mesenchymal stem cells (hPMSCs) ...

    Authors: Jiafeng Lu, Zhenxing Liu, Mingkai Shu, Liya Zhang, Wenjuan Xia, Liuna Tang, Jincheng Li, Boxian Huang and Hong Li

    Citation: Stem Cell Research & Therapy 2021 12:199

    Content type: Research

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  32. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is an intractable nonbacterial inflammatory disease. Mesenchymal stem cells (MSCs) derived from human induced pluripotent stem cells (hiPSCs, iMSCs) h...

    Authors: Xufeng Peng, Hailin Guo, Ji Yuan, Yu Chen, Yuguo Xia, Lin Wang, Ying Wang, Yichen Huang, Hua Xie, Yang Wang and Fang Chen

    Citation: Stem Cell Research & Therapy 2021 12:198

    Content type: Research

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  33. The senescence of dermal fibroblasts (DFLs) leads to an imbalance in the synthesis and degradation of extracellular matrix (ECM) proteins, presenting so-called senescence-associated secretory phenotype (SASP),...

    Authors: Xiangnan Zhao, Yue Liu, Pingping Jia, Hui Cheng, Chen Wang, Shang Chen, Haoyan Huang, Zhibo Han, Zhong-Chao Han, Krzysztof Marycz, Xiaoniao Chen and Zongjin Li

    Citation: Stem Cell Research & Therapy 2021 12:196

    Content type: Research

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  34. Propofol can have adverse effects on developing neurons, leading to cognitive disorders, but the mechanism of such an effect remains elusive. Here, we aimed to investigate the effect of propofol on neuronal de...

    Authors: Xiaoqing Fan, Haoran Yang, Lizhu Hu, Delong Wang, Ruiting Wang, Aijun Hao and Xueran Chen

    Citation: Stem Cell Research & Therapy 2021 12:195

    Content type: Research

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  35. While therapeutic success of the limbal tissue or cell transplantation to treat severe cases of limbal stem cell (LSC) deficiency (LSCD) strongly depends on the percentage of LSCs within the transplanted cells...

    Authors: Alexandra Norrick, Jasmina Esterlechner, Elke Niebergall-Roth, Ulf Dehio, Samar Sadeghi, Hannes M. Schröder, Seda Ballikaya, Nicole Stemler, Christoph Ganss, Kathrin Dieter, Ann-Kathrin Dachtler, Patrick Merz, Saadettin Sel, James Chodosh, Claus Cursiefen, Natasha Y. Frank…

    Citation: Stem Cell Research & Therapy 2021 12:194

    Content type: Research

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  36. Life-long peritoneal dialysis (PD) as a renal replacement therapy is limited by peritoneal fibrosis. Previous studies showed immunomodulatory and antifibrotic effects of adipose-derived mesenchymal stem cells ...

    Authors: Chih-Yu Yang, Pu-Yuan Chang, Jun-Yi Chen, Bo-Sheng Wu, An-Hang Yang and Oscar Kuang-Sheng Lee

    Citation: Stem Cell Research & Therapy 2021 12:193

    Content type: Research

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  37. Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical applications have received much attention from the global scientific community in an increasing manner. Firstly, MSCs wer...

    Authors: Alexander Markov, Lakshmi Thangavelu, Surendar Aravindhan, Angelina Olegovna Zekiy, Mostafa Jarahian, Max Stanley Chartrand, Yashwant Pathak, Faroogh Marofi, Somayeh Shamlou and Ali Hassanzadeh

    Citation: Stem Cell Research & Therapy 2021 12:192

    Content type: Review

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  38. The objective was to explore the therapeutic effect of autologous adipose-derived stem cells (ADSCs) combined with ShakeGel™3D transplantation to activate the BMP7-Smad5 signaling pathway to treat intrauterine...

    Authors: Yun-xia Zhao, Shao-rong Chen, Qiao-yi Huang, Wei-can Chen, Tian Xia, Yan-chuan Shi, Hong-zhi Gao, Qi-yang Shi and Shu Lin

    Citation: Stem Cell Research & Therapy 2021 12:191

    Content type: Research

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  39. Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. Compounds that target tissue-specific transcription factors could ...

    Authors: Mika J. Välimäki, Robert S. Leigh, Sini M. Kinnunen, Alexander R. March, Ana Hernández de Sande, Matias Kinnunen, Markku Varjosalo, Merja Heinäniemi, Bogac L. Kaynak and Heikki Ruskoaho

    Citation: Stem Cell Research & Therapy 2021 12:190

    Content type: Research

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  40. The potential of regenerative medicine to improve human health has led to the rapid expansion of stem cell clinics throughout the world with varying levels of regulation and oversight. This has led to a market...

    Authors: Javier Chavez, Neal A. Shah, Severin Ruoss, Raphael E. Cuomo, Samuel R. Ward and Tim K. Mackey

    Citation: Stem Cell Research & Therapy 2021 12:189

    Content type: Research

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  41. Neural stem cell (NSC) therapy remains one of the most potential approaches for the treatment of neurological disorders. The discovery of human induced pluripotent stem cells (hiPSCs) and the establishment of ...

    Authors: Shuai Li, Huifang Zhao, Xiaobo Han, Bin Ni, Lang He, Omar Mukama, Jean de Dieu Habimana, Zuoxian Lin, Rongqi Huang, Hualin Huang, Chao Tian, Feng Tang and Zhiyuan Li

    Citation: Stem Cell Research & Therapy 2021 12:188

    Content type: Research

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  42. Mesenchymal stromal cells (MSCs) have been studied with increasing intensity as clinicians and researchers strive to understand the ability of MSCs to modulate disease progression and promote tissue regenerati...

    Authors: Ashley A. Krull, Deborah O. Setter, Tania F. Gendron, Sybil C. L. Hrstka, Michael J. Polzin, Joseph Hart, Amel Dudakovic, Nicolas N. Madigan, Allan B. Dietz, Anthony J. Windebank, Andre J. van Wijnen and Nathan P. Staff

    Citation: Stem Cell Research & Therapy 2021 12:187

    Content type: Research

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  43. Ovarian cancer stem cells (OCSC), endowed with tumor-initiating and self-renewal capacity, would account not only for the tumor growth, the peritoneal metastasis, and the relapse, but also for the acquisition ...

    Authors: Kun Wang, Yiyang Wang, Yuanjian Wang, Shujie Liu, Chunyan Wang, Shuo Zhang, Tianli Zhang and Xingsheng Yang

    Citation: Stem Cell Research & Therapy 2021 12:186

    Content type: Research

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  44. This study aims to investigate whether apoptosis repressor with caspase recruitment domain (ARC) could promote survival and enhance osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMS...

    Authors: Longwei Hu, Yang Wang, Hongya Pan, Kathreena Kadir, Jin Wen, Siyi Li and Chenping Zhang

    Citation: Stem Cell Research & Therapy 2021 12:185

    Content type: Research

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  45. Acute lung injury (ALI) and in its severe form, acute respiratory distress syndrome (ARDS), results in increased pulmonary vascular inflammation and permeability and is a major cause of mortality in many criti...

    Authors: Maria Florian, Jia-Pey Wang, Yupu Deng, Luciana Souza-Moreira, Duncan J. Stewart and Shirley H. J. Mei

    Citation: Stem Cell Research & Therapy 2021 12:184

    Content type: Research

    Published on:

  46. Peripheral arterial disease (PAD) affects millions of people and compromises quality of life. Critical limb ischemia (CLI), which is the most advanced stage of PAD, can cause nonhealing ulcers and strong chron...

    Authors: Yuan-chi Teng, Alfredo Leonardo Porfírio-Sousa, Giulia Magri Ribeiro, Marcela Corso Arend, Lindolfo da Silva Meirelles, Elizabeth Suchi Chen, Daniela Santoro Rosa and Sang Won Han

    Citation: Stem Cell Research & Therapy 2021 12:183

    Content type: Research

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  47. Sjögren’s syndrome (SS) is a chronic autoimmune disease primarily characterized by inflammation in the salivary and lacrimal glands. Activated T cells contribute to disease pathogenesis by producing proinflamm...

    Authors: Mayu Matsumura-Kawashima, Kenichi Ogata, Masafumi Moriyama, Yuka Murakami, Tatsuya Kawado and Seiji Nakamura

    Citation: Stem Cell Research & Therapy 2021 12:182

    Content type: Research

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