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  1. Understanding mechanisms and manifestations of cardiovascular risk factors, including diabetes, on vascular cells such as endothelial cells, pericytes, and vascular smooth muscle cells, remains elusive partly ...

    Authors: Hojjat Naderi-Meshkin, Victoria A. Cornelius, Magdalini Eleftheriadou, Koray Niels Potel, Wiwit Ananda Wahyu Setyaningsih and Andriana Margariti
    Citation: Stem Cell Research & Therapy 2023 14:292
    Content type: Review Published on:

  2. Abdominal obesity is appreciated as a major player in insulin resistance and metabolically dysfunctional adipose tissue. Inappropriate extracellular matrix (ECM) remodelling and functional alterations in human...

    Authors: Xueya Han, Weihong Li, Xu He, Xin Lu, Yu Zhang, Yaqiong Li, Guoyun Bi, Xuqing Ma, Xiaowu Huang, Rixing Bai and Haiyan Zhang
    Citation: Stem Cell Research & Therapy 2023 14:291
    Content type: Research Published on:

  3. Neurosphere medium (NSM) and self-renewal medium (SRM) were widely used to isolate enteric neural stem cells (ENSCs) in the form of neurospheres. ENSCs or their neurosphere forms were neurogenic and gliogenic,...

    Authors: Jeng-Chang Chen, Wendy Yang, Li-Yun Tseng and Hsueh-Ling Chang
    Citation: Stem Cell Research & Therapy 2023 14:290
    Content type: Research Published on:

  4. Mesenchymal stromal cells (MSCs) have a dynamic secretome that plays a critical role in tissue repair and regeneration. However, studying the MSC secretome in mixed-culture disease models remains challenging. ...

    Authors: Jeremy D. Burgess, Danilyn Amerna, Emily S. Norton, Tammee M. Parsons, Ralph B. Perkerson III, Ayman H. Faroqi, Zbigniew K. Wszolek, Hugo Guerrero Cazares, Takahisa Kanekiyo, Marion Delenclos and Pamela J. McLean
    Citation: Stem Cell Research & Therapy 2023 14:289
    Content type: Method Published on:

  5. Liver fibrosis is prevalent among chronic diseases of the liver and represents a major health burden worldwide. Growth differentiation factor 7 (GDF7), a member of the TGFβ protein superfamily, has been recent...

    Authors: Defu Kong, Apostolos Mourtzinos, Janette Heegsma, Hans Blokzijl, Vincent E. de Meijer and Klaas Nico Faber
    Citation: Stem Cell Research & Therapy 2023 14:288
    Content type: Research Published on:

  6. Evolving mutations of the novel coronavirus continue to fuel up the pandemic. The virus affects the human respiratory system along with other body systems, causing several sequelae in the survivors of the dise...

    Authors: Ridhima Vij, Hosu Kim, Hyeonggeun Park, Thanh Cheng, Djamchid Lotfi and Donna Chang
    Citation: Stem Cell Research & Therapy 2023 14:287
    Content type: Research Published on:

  7. Stem cell therapy is a promising therapeutic approach for inherited retinal diseases (IRDs). This study aims to quantitatively examine the effectiveness and safety of stem cell therapy for patients with IRDs, ...

    Authors: Xiaodong Chen, Ningda Xu, Jiarui Li, Mingwei Zhao and Lvzhen Huang
    Citation: Stem Cell Research & Therapy 2023 14:286
    Content type: Review Published on:

  8. Previous studies have verified the dysfunction of mesenchymal stem cells (MSCs) for immunoregulation in acquired aplastic anemia (AA) patients. Exosomes derived from MSCs can partially substitute MSCs acting a...

    Authors: Shichong Wang, Jiali Huo, Yilin Liu, Lingyun Chen, Xiang Ren, Xingxin Li, Min Wang, Peng Jin, Jinbo Huang, Neng Nie, Jing Zhang, Yingqi Shao, Meili Ge and Yizhou Zheng
    Citation: Stem Cell Research & Therapy 2023 14:285
    Content type: Research Published on:

  9. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are widely used in cell therapy due to their robust immunomodulatory and tissue regenerative capabilities. Currently, the predominant method for obtaining...

    Authors: Xia Wang, Liming Ouyang, Wenxia Chen, Yulin Cao and Lixin Zhang
    Citation: Stem Cell Research & Therapy 2023 14:284
    Content type: Research Published on:

  10. Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease characterized by synovial inflammation-mediated progressive destruction of the cartilage and bone, resulting in reduced quality of life. W...

    Authors: Eun Wha Choi, I.-Rang Lim, Ji Hong Park, Jiwoo Song, Bongkum Choi and Sungjoo Kim
    Citation: Stem Cell Research & Therapy 2023 14:283
    Content type: Research Published on:

  11. Hematopoiesis is a complex process in which hematopoietic stem cells are differentiated into all mature blood cells (red blood cells, white blood cells, and platelets). Different microRNAs (miRNAs) involve in ...

    Authors: Seyed Mahdi Nassiri, Neda Ahmadi Afshar and Parsa Almasi
    Citation: Stem Cell Research & Therapy 2023 14:282
    Content type: Review Published on:

  12. T helper 2 (Th2) cells are thought to play critical roles in allergic conjunctivitis (AC). They release inflammatory cytokines to promote an allergic response in AC. Due to individual heterogeneity and long-te...

    Authors: Dongli Li, Qingjian Ou, Qi Shen, Michael Mingze Lu, Jing-Ying Xu, Caixia Jin, Furong Gao, Juan Wang, Jingfa Zhang, Jieping Zhang, Jiao Li, Lixia Lu, Guo-Tong Xu and Haibin Tian
    Citation: Stem Cell Research & Therapy 2023 14:281
    Content type: Research Published on:

  14. In vitro production of hematopoietic stem/progenitor cells (HSPCs) from human-induced pluripotent stem cells (hiPSCs) provides opportunities for fundamental research, disease modeling, and large-scale producti...

    Authors: Chuti Laowtammathron, Chanchao Lorthongpanich, Nittaya Jiamvoraphong, Pimonwan Srisook, Phatchanat Klaihmon, Pakpoom Kheolamai, Sudjit Luanpitpong and Surapol Issaragrisil
    Citation: Stem Cell Research & Therapy 2023 14:279
    Content type: Research Published on:

  15. Human induced pluripotent stem cell-derived endothelial cells (hiPSC-ECs) exhibit the potential to repair the injured heart after myocardial infarction (MI) by promoting neovascularization and cardiomyocyte su...

    Authors: Hao Li, Lu Wang, Teng Ma, Zhongmin Liu and Ling Gao
    Citation: Stem Cell Research & Therapy 2023 14:278
    Content type: Research Published on:

  16. As a kind of mesenchymal-like stromal cells, endometrial regenerative cells (ERCs) have been demonstrated effective in the treatment of Concanavalin A (Con A)-induced hepatitis. However, the therapeutic mechan...

    Authors: Hong Qin, Chenglu Sun, Dejun Kong, Yanglin Zhu, Bo Shao, Shaohua Ren, Hongda Wang, Jingyi Zhang, Yini Xu and Hao Wang
    Citation: Stem Cell Research & Therapy 2023 14:277
    Content type: Research Published on:

  20. Identification of promising targeted antigens that exhibited cancer-specific expression is a crucial step in the development of novel antibody-targeted therapies. We here aimed to investigate the anti-tumor ac...

    Authors: Hui-Qi Liu, Li-Xin Sun, Long Yu, Jun Liu, Li-Chao Sun, Zhi-Hua Yang, Xiong Shu and Yu-Liang Ran
    Citation: Stem Cell Research & Therapy 2023 14:273
    Content type: Research Published on:

  21. Though articular cartilage stem cell (ACSC)-based therapies have been demonstrated to be a promising option in the treatment of diseased joints, the wide variety of cell isolation, the unknown therapeutic targ...

    Authors: Zhi-Ling Li, Xiao-Tong Li, Rui-Cong Hao, Fei-Yan Wang, Yu-Xing Wang, Zhi-Dong Zhao, Pei-Lin Li, Bo-Feng Yin, Ning Mao, Li Ding and Heng Zhu
    Citation: Stem Cell Research & Therapy 2023 14:253
    Content type: Research Published on:

  22. Extracellular vesicles (EVs) from human umbilical cord mesenchymal stem cells (hUMSCs) are widely considered to be the best mediators for cell-free therapy. An understanding of their composition, especially RN...

    Authors: Dong Yu, Yue Mei, Ling Wang, Yunpeng Zhao, Xingfei Fan, Dong Liang, Li Li, Jie Zhu, Sisi Bi, Xue Wang, Zhongquan Qi, Lie Zhu and Yue Wang
    Citation: Stem Cell Research & Therapy 2023 14:272
    Content type: Research Published on:

  23. Inflammatory bowel disease (IBD) is a global health problem in which gut microbiota dysbiosis plays a pivotal pathogenic role. Mesenchymal stem cells (MSCs) therapy has emerged as a prospective novel tool for ...

    Authors: Airu Liu, Xiaonan Liang, Wenxin Wang, Chen Wang, Jia Song, Jinbo Guo, Donglei Sun, Dong Wang, Mei Song, Jiaming Qian and Xiaolan Zhang
    Citation: Stem Cell Research & Therapy 2023 14:271
    Content type: Research Published on:

  24. Mesenchymal stromal cells (MSCs) are excessively investigated in the context of inflammation-driven diseases, but the clinical results are often moderate. MSCs are naturally activated by inflammatory signals, ...

    Authors: Anton Selich, Jenni Fleischauer, Tina Roepke, Luisa Weisskoeppel, Melanie Galla, Constantin von Kaisenberg, Ulrich A. Maus, Axel Schambach and Michael Rothe
    Citation: Stem Cell Research & Therapy 2023 14:270
    Content type: Research Published on:

  25. The appearance of skin scars is known as one of the main side effects of skin burns. Stromal vascular fraction (SVF), as a rich source of cell populations with tissue regeneration properties, plays an importan...

    Authors: Masoumeh Roohaninasab, Fariba Khodadad, Afsaneh Sadeghzadeh-Bazargan, Najmolsadat Atefi, Sona Zare, Alireza Jafarzadeh, Seyyedeh Tahereh Rahimi, Maryam Nouri, Mohammad Ali Nilforoushzadeh, Elham Behrangi and Azadeh Goodarzi
    Citation: Stem Cell Research & Therapy 2023 14:269
    Content type: Research Published on:

  26. Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease of unknown etiology. The most common form of this disease is chronic inflammatory arthritis, which begins with inflammation of the synovia...

    Authors: Mahnaz Babaahmadi, Behnoosh Tayebi, Nima Makvand Gholipour, Mehrnaz Tayebi Kamardi, Sahel Heidari, Hossein Baharvand, Mohamadreza Baghaban Eslaminejad, Ensiyeh Hajizadeh-Saffar and Seyedeh-Nafiseh Hassani
    Citation: Stem Cell Research & Therapy 2023 14:268
    Content type: Review Published on:

  27. Recent studies have shown that mesenchymal stem cell (MSC) therapy has potential therapeutic effects for patients with end-stage liver diseases. However, a consensus on the efficacy and safety of MSCs has not ...

    Authors: Huimin Wang, Weiqi Yao, Yuyan Wang, Haibo Dong, Tengyun Dong, Wangyi Zhou, Lingling Cui, Lulu Zhao, Yu Zhang, Lei Shi and Yingan Jiang
    Citation: Stem Cell Research & Therapy 2023 14:267
    Content type: Research Published on:

  28. Polymorphic ventricular tachycardia (PMVT) is a rare genetic disease associated with structurally normal hearts which in 8% of cases can lead to sudden cardiac death, typically exercise-induced. We previously ...

    Authors: Yvonne Sleiman, Steven Reiken, Azzouz Charrabi, Fabrice Jaffré, Leah R. Sittenfeld, Jean-Luc Pasquié, Sarah Colombani, Bruce B. Lerman, Shuibing Chen, Andrew R. Marks, Jim W. Cheung, Todd Evans, Alain Lacampagne and Albano C. Meli
    Citation: Stem Cell Research & Therapy 2023 14:266
    Content type: Research Published on:

  29. Down syndrome (DS) clinical multisystem condition is generally considered the result of a genetic imbalance generated by the extra copy of chromosome 21. Recent discoveries, however, demonstrate that the molec...

    Authors: Salvatore Vaiasicca, Gianmarco Melone, David W. James, Marcos Quintela, Alessandra Preziuso, Richard H. Finnell, Robert Steven Conlan, Lewis W. Francis and Bruna Corradetti
    Citation: Stem Cell Research & Therapy 2023 14:265
    Content type: Research Published on:

  30. Mesenchymal stromal cell (MSC) transplantation can improve the left ventricular ejection fraction (LVEF) after an acute myocardial infarction (AMI). Transplanted MSCs exert a paracrine effect, which might be a...

    Authors: Armin Attar, Mohsen Farjoud Kouhanjani, Kamran Hessami, Massoud Vosough, Javad Kojuri, Mani Ramzi, Seyed Ali Hosseini, Marjan Faghih and Ahmad Monabati
    Citation: Stem Cell Research & Therapy 2023 14:264
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2024 15:40

  31. Perioperative neurocognitive disorder (PND) is a key complication affecting older individuals after anesthesia and surgery. Failure to translate multiple pharmacological therapies for PND from preclinical stud...

    Authors: Penghui Wei, Min Jia, Xiangyi Kong, Wenyuan Lyu, Hao Feng, Xinyi Sun, Jianjun Li and Jian-jun Yang
    Citation: Stem Cell Research & Therapy 2023 14:263
    Content type: Research Published on:

  32. The loss of germ cells and spermatogenic failure in non-obstructive azoospermia are believed to be the main causes of male infertility. Laboratory studies have used in vitro testicular models and different 3-d...

    Authors: Maryam Salem, Farnaz Khadivi, Parinaz Javanbakht, Sina Mojaverrostami, Mehdi Abbasi, Narjes Feizollahi, Yasaman Abbasi, Ehsan Heidarian and Farzane Rezaei Yazdi
    Citation: Stem Cell Research & Therapy 2023 14:262
    Content type: Review Published on:

  33. An effective treatment for acute non-arteritic ischemic optic neuropathy (NA-AION) has not been known or proven yet. Previous studies have suggested a neuroprotective effect of allogeneic bone marrow-derived m...

    Authors: Jose C. Pastor, Salvador Pastor-Idoate, Marina López-Paniagua, Marta Para, Francisco Blazquez, Esther Murgui, Verónica García and Rosa M. Coco-Martín
    Citation: Stem Cell Research & Therapy 2023 14:261
    Content type: Research Published on:

  35. Mesenchymal stromal cells (MSCs) have broad potential as a cell therapy including for the treatment of drug-resistant inflammatory conditions with abnormal T cell proliferation such as graft-versus-host diseas...

    Authors: Shu Hui Neo, Zhisheng Her, Rashidah Othman, Ching Ann Tee, Li Ching Ong, Yuehua Wang, Irwin Tan, Jaylen Tan, Yanmeng Yang, Zheng Yang, Qingfeng Chen and Laurie A. Boyer
    Citation: Stem Cell Research & Therapy 2023 14:259
    Content type: Research Published on:

  36. Stromal vascular fraction (SVF) cells, and the adipose-derived mesenchymal stem cells they contain, have shown enhanced wound healing in vitro and in vivo, yet their clinical application has been limited. In t...

    Authors: Stefan Balko, Evan Kerr, Ed Buchel, Sarvesh Logsetty and Afshin Raouf
    Citation: Stem Cell Research & Therapy 2023 14:258
    Content type: Short report Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2023 14:323

  37. Delayed healing of diabetic cutaneous wounds is one of the most common complications of type 2 diabetes mellitus (T2DM), which can bring great distress to patients. In diabetic patients, macrophages accumulate...

    Authors: Yiming Wang, Lin Jing, Xiao Lei, Zhen Ma, Bei Li, Yuanyuan Shi, Wuyang Zhang, Yuan Li, Hongzhi Zhou, Kaijin Hu, Yang Xue and Yan Jin
    Citation: Stem Cell Research & Therapy 2023 14:257
    Content type: Research Published on:

  38. Allo-HSCT is a definite approach for the management of a wide variety of lethal and debilitating malignant and non-malignant disorders. However, its two main complications, acute and chronic graft-versus-host ...

    Authors: Rashin Mohseni, Pouya Mahdavi Sharif, Maryam Behfar, Mohammad Reza Modaresi, Rohola Shirzadi, Mahta Mardani, Leila Jafari, Fahimeh Jafari, Zeynab Nikfetrat and Amir Ali Hamidieh
    Citation: Stem Cell Research & Therapy 2023 14:256
    Content type: Research Published on:

  39. CDC42 is a member of Rho GTPase family, acting as a molecular switch to regulate cytoskeleton organization and junction maturation of epithelium in organ development. Tooth root pattern is a highly complicated...

    Authors: Tao Zhou, Guoqing Chen, Yuchan Xu, Shuning Zhang, Huilin Tang, Tao Qiu and Weihua Guo
    Citation: Stem Cell Research & Therapy 2023 14:255
    Content type: Research Published on:

  40. Peripheral nerve injury (PNI) is one of the public health concerns that can result in a loss of sensory or motor function in the areas in which injured and non-injured nerves come together. Up until now, there...

    Authors: Mojdeh Salehi Namini, Fatemeh Daneshimehr, Nima Beheshtizadeh, Vahid Mansouri, Jafar Ai, Hossein Kargar Jahromi and Somayeh Ebrahimi-Barough
    Citation: Stem Cell Research & Therapy 2023 14:254
    Content type: Review Published on:

  41. This prospective clinical case series aimed to evaluate the effect of suprachoroidal implantation of mesenchymal stem cells (MSCs) in the form of spheroids as a stem cell therapy for retinitis pigmentosa (RP) ...

    Authors: Berna Özkan, Büşra Yılmaz Tuğan, Cansu Hemşinlioğlu, Gözde Sır Karakuş, Özlem Şahin and Ercüment Ovalı
    Citation: Stem Cell Research & Therapy 2023 14:252
    Content type: Research Published on:

  42. Hematopoietic stem cells (HSCs) with the ability to self-renew and differentiate are responsible for maintaining the supply of all types of blood cells. The complex and delicate microenvironment surrounding HS...

    Authors: Guolin Shi, Pan Zhang, Xi Zhang, Jing Li, Xinmin Zheng, Jinxiao Yan, Nu Zhang and Hui Yang
    Citation: Stem Cell Research & Therapy 2023 14:251
    Content type: Review Published on:

  43. Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are a promising cell-free therapy for acute lung injury (ALI). To date, no studies have investigated their biodistribution in ALI or discerned ...

    Authors: Alvin Tieu, Duncan J. Stewart, Damian Chwastek, Casey Lansdell, Dylan Burger and Manoj M. Lalu
    Citation: Stem Cell Research & Therapy 2023 14:250
    Content type: Research Published on:

  44. Cardiovascular complications significantly augment the overall COVID-19 mortality, largely due to the susceptibility of human cardiomyocytes (CMs) to SARS-CoV-2 virus. SARS-CoV-2 virus encodes 27 genes, whose ...

    Authors: Juli Liu, Shiyong Wu, Yucheng Zhang, Cheng Wang, Sheng Liu, Jun Wan and Lei Yang
    Citation: Stem Cell Research & Therapy 2023 14:249
    Content type: Research Published on:

  45. Disco-interacting protein 2 homolog B is a member of the Dip2 family encoded by the Dip2b gene. Dip2b is widely expressed in neuro-related tissues and is essential in axonal outgrowth during embryogenesis.

    Authors: Mingze Yao, Yuanqing Pan, Tinglin Ren, Caiting Yang, Yu Lei, Xiaoyu Xing, Lei Zhang, Xiaogang Cui, Yaowu Zheng, Li Xing and Changxin Wu
    Citation: Stem Cell Research & Therapy 2023 14:248
    Content type: Research Published on:

  46. Dissecting complex interactions among transcription factors (TFs), microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are central for understanding heart development and function. Although computational appr...

    Authors: Shumin Li, Bin Yan, Binbin Wu, Junhao Su, Jianliang Lu, Tak-Wah Lam, Kenneth R. Boheler, Ellen Ngar-Yun Poon and Ruibang Luo
    Citation: Stem Cell Research & Therapy 2023 14:247
    Content type: Research Published on:

  47. Inflammatory memory or trained immunity is a recently described process in immune and non-immune tissue resident cells, whereby previous exposure to inflammation mediators leads to a faster and stronger respon...

    Authors: Jacopo Morroni, Anna Benedetti, Lorenza Esposito, Marco De Bardi, Giovanna Borsellino, Carles Sanchez Riera, Lorenzo Giordani, Marina Bouche and Biliana Lozanoska-Ochser
    Citation: Stem Cell Research & Therapy 2023 14:246
    Content type: Research Published on:

  48. Despite increasing clinical investigations underscoring the efficacy and safety of adipose-derived mesenchymal stem cells (AD-MSCs) therapy in knee osteoarthritis (KOA), no article has recently reviewed the ce...

    Authors: Zongyuan Huang, Shuai Zhang, Mingde Cao, Zhujian Lin, Ling Kong, Xin Wu, Qianshi Guo, Yuxiang Ouyang and Yancheng Song
    Citation: Stem Cell Research & Therapy 2023 14:245
    Content type: Review Published on:

  49. Synovial fluid mesenchymal stem cells (SF-MSCs) originate in the synovium and contribute to the endogenous repair of damaged intra-articular tissues. Here, we clarified the relationship between their numbers a...

    Authors: Hideto Furuoka, Kentaro Endo and Ichiro Sekiya
    Citation: Stem Cell Research & Therapy 2023 14:244
    Content type: Research Published on:

  50. The capacity of skeletal muscles to regenerate relies on Pax7+ muscle stem cells (MuSC). While in vitro-amplified MuSC are activated and lose part of their regenerative capacity, in vitro-generated human muscle r...

    Authors: Axelle Bouche, Benoit Borner, Chloé Richard, Ysaline Grand, Didier Hannouche and Thomas Laumonier
    Citation: Stem Cell Research & Therapy 2023 14:243
    Content type: Research Published on:
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