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  1. Equine metabolic syndrome (EMS) refers to a cluster of associated abnormalities and metabolic disorders, including insulin resistance and adiposity. The numerous biological properties of mesenchymal stem cells...

    Authors: Lynda Bourebaba, Fatiha Bedjou, Michael Röcken and Krzysztof Marycz

    Citation: Stem Cell Research & Therapy 2019 10:178

    Content type: Research

    Published on:

  2. Human decidual stromal cells (DSCs) are involved in the maintenance and development of pregnancy, in which they play a key role in the induction of immunological maternal–fetal tolerance. Precursors of DSCs (p...

    Authors: Raquel Muñoz-Fernández, Claudia De La Mata, Francisco Requena, Francisco Martín, Pablo Fernandez-Rubio, Tatiana Llorca, Maria José Ruiz-Magaña, Carmen Ruiz-Ruiz and Enrique G. Olivares

    Citation: Stem Cell Research & Therapy 2019 10:177

    Content type: Research

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  3. Molecular mechanisms underlying the regenerative process induced by stem cells in tissue-engineered urinary bladder are poorly explained. The study was performed to explore the pathways associated with regener...

    Authors: Marta Pokrywczynska, Marta Rasmus, Arkadiusz Jundzill, Daria Balcerczyk, Jan Adamowicz, Karolina Warda, Lukasz Buchholz and Tomasz Drewa

    Citation: Stem Cell Research & Therapy 2019 10:176

    Content type: Research

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  4. Cancer stem cells (CSCs) play a critical role in tumor development and progression and are involved in cancer metastasis. The role of reactive oxygen species (ROS) in CSCs and cancer metastasis remains controv...

    Authors: Caihua Wang, Liming Shao, Chi Pan, Jun Ye, Zonghui Ding, Jia Wu, Qin Du, Yuezhong Ren and Chunpeng Zhu

    Citation: Stem Cell Research & Therapy 2019 10:175

    Content type: Research

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  5. Our previous study proved that nanofat could enhance fat graft survival by promoting neovascularization. Fat extract (FE), a cell-free component derived from nanofat, also possesses proangiogenic activity.

    Authors: Hongjie Zheng, Ziyou Yu, Mingwu Deng, Yizuo Cai, Xiangsheng Wang, Yuda Xu, Lu Zhang, Wenjie Zhang and Wei Li

    Citation: Stem Cell Research & Therapy 2019 10:174

    Content type: Research

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  6. Hematopoietic stem cell (HSC) transplantation has been widely applied to the treatment of malignant blood diseases. However, limited number of functional HSCs hinders successful transplantation. The purpose of...

    Authors: Yu Zhang, Bin Shen, Xin Guan, Meng Qin, Zhihua Ren, Yupo Ma, Wei Dai, Xinxin Ding and Yongping Jiang

    Citation: Stem Cell Research & Therapy 2019 10:173

    Content type: Research

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  7. Clinically, for stem cell-based therapy (SCBT), autologous stem cells are considered better than allogenic stem cells because of little immune rejection and no risk of communicable disease infection. However, ...

    Authors: Anyuan Shi, Aerali Heinayati, Dongyu Bao, Huifen Liu, Xiaochen Ding, Xin Tong, Liudi Wang, Bin Wang and Haiyan Qin

    Citation: Stem Cell Research & Therapy 2019 10:172

    Content type: Research

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  8. Administration of the iron chelator deferasirox (DFX) in transfusion-dependent patients occasionally results in haematopoiesis recovery by a mechanism remaining elusive. This study aimed to investigate at a mo...

    Authors: Tiziana Tataranni, Carmela Mazzoccoli, Francesca Agriesti, Luciana De Luca, Ilaria Laurenzana, Vittorio Simeon, Vitalba Ruggieri, Consiglia Pacelli, Gerardo Della Sala, Pellegrino Musto, Nazzareno Capitanio and Claudia Piccoli

    Citation: Stem Cell Research & Therapy 2019 10:171

    Content type: Research

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  9. Exosomes derived from dental pulp stem cells (DPSCs) can be used as biomimetic tools to induce odontogenic differentiation of stem cells, but the regulatory mechanisms and functions of exosome-encapsulated mic...

    Authors: Xiaoli Hu, Yingqun Zhong, Yuanyuan Kong, Yanan Chen, Junming Feng and Jianmao Zheng

    Citation: Stem Cell Research & Therapy 2019 10:170

    Content type: Research

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  10. Due to its complex pathogenesis and low clinical cure rate, bisphosphonate-related osteonecrosis of the jaw (BRONJ) poses a substantial challenge for oral and maxillofacial surgeons. Therefore, the treatment o...

    Authors: Xiaolong Zang, Linhai He, Lu Zhao, Yang He, E. Xiao and Yi Zhang

    Citation: Stem Cell Research & Therapy 2019 10:169

    Content type: Research

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  11. Spinal metastasis is a major challenge in patients with advanced lung cancer, but the mechanisms in the organotropism of metastasis are still unclear. Adipose-derived mesenchymal stem cells (ADSCs) exhibit can...

    Authors: Yan Wang, Yijing Chu, Xianfeng Ren, Hongfei Xiang, Yongming Xi, Xuexiao Ma, Kai Zhu, Zhu Guo, Chuanli Zhou, Guoqing Zhang and Bohua Chen

    Citation: Stem Cell Research & Therapy 2019 10:168

    Content type: Research

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  12. Ischemic heart diseases are still a threat to human health. Human pluripotent stem cell-based transplantation exhibits great promise in cardiovascular disease therapy, including heart ischemia. The purpose of ...

    Authors: You Yu, Nianci Qin, Xing-Ai Lu, Jingjing Li, Xinglong Han, Xuan Ni, Lingqun Ye, Zhenya Shen, Weiqian Chen, Zhen-Ao Zhao, Wei Lei and Shijun Hu

    Citation: Stem Cell Research & Therapy 2019 10:167

    Content type: Research

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  13. Cell reprogramming is a promising avenue for cell-based therapies as it allows for the generation of multipotent, unipotent, or mature somatic cells without going through a pluripotent state. While the use of ...

    Authors: Jan-Eric Ahlfors, Ashkan Azimi, Rouwayda El-Ayoubi, Alexander Velumian, Ilan Vonderwalde, Cecile Boscher, Oana Mihai, Sarathi Mani, Marina Samoilova, Mohamad Khazaei, Michael G. Fehlings and Cindi M Morshead

    Citation: Stem Cell Research & Therapy 2019 10:166

    Content type: Research

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  14. Mounting evidence has shown that a novel subset of mesenchymal stem cells (MSCs) derived from human gingiva referred to as gingival mesenchymal stem cells (GMSCs) displays a greater immunotherapeutic potential...

    Authors: Jun Zhao, Julie Wang, Junlong Dang, Wangyu Zhu, Yaqiong Chen, Ximei Zhang, Junliang Xie, Bo Hu, Feng Huang, Baoqing Sun, Joseph A. Bellanti and Song Guo Zheng

    Citation: Stem Cell Research & Therapy 2019 10:165

    Content type: Research

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  15. Contrary to the minimal criteria proposed by the International Society for Cell and Gene Therapy for defining multipotent mesenchymal stromal cells (MSC), human leukocyte antigen (HLA)-DR expression is largely...

    Authors: Marta Grau-Vorster, Anita Laitinen, Johanna Nystedt and Joaquim Vives

    Citation: Stem Cell Research & Therapy 2019 10:164

    Content type: Research

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  16. Pulmonary emphysema is a major component of chronic obstructive pulmonary disease (COPD). Emphysema progression attributed not only to alveolar structure loss and pulmonary regeneration impairment, but also to...

    Authors: Ying-Wei Lan, Jing-Chan Yang, Chih-Ching Yen, Tsung-Teng Huang, Ying-Cheng Chen, Hsiao-Ling Chen, Kowit-Yu Chong and Chuan-Mu Chen

    Citation: Stem Cell Research & Therapy 2019 10:163

    Content type: Research

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  17. The authors have retracted this article [1] because there is erroneous data in Figure 1C. Flow cytometry results of EPC cell markers CD31 and CD45 could not be replicated. Due to incorrect cell markers, the ce...

    Authors: Jiacheng Sun, Zhiwei Zhang, Teng Ma, Ziying Yang, Jinlong Zhang, Xuan Liu, Da Lu, Zhenya Shen, Junjie Yang and Qingyou Meng

    Citation: Stem Cell Research & Therapy 2019 10:162

    Content type: Retraction Note

    Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:223

  18. Idiopathic pulmonary fibrosis is characterized by loss of lung epithelial cells and inexorable progression of fibrosis with no effective and approved treatments. The distal airway stem/progenitor cells (DASCs)...

    Authors: Yun Shi, Mingqing Dong, Yueqing Zhou, Wangping Li, Yongheng Gao, Luyao Han, Min Chen, Hongwei Lin, Wei Zuo and Faguang Jin

    Citation: Stem Cell Research & Therapy 2019 10:161

    Content type: Research

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  19. To investigate the effect of ectopic high expression of OCT4 on the stemness characteristics of bone marrow-derived mesenchymal stromal cells (BM-MSCs).

    Authors: Xiaoping Guo, Yongmin Tang, Ping Zhang, Sisi Li, Yuanyuan Chen, Baiqin Qian, Hongqiang Shen and Ning Zhao

    Citation: Stem Cell Research & Therapy 2019 10:160

    Content type: Research

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  20. To investigate the potential effect of IP7 on the autophagy and apoptosis of bone marrow mesenchymal stem cells (BM-MSCs) caused by hypoxia.

    Authors: Jingyu Deng, Chao Yang, Yong Wang, Ming Yang, Haixu Chen, Hongjuan Ning, Chengzhu Wang, Yanjun Liu, Zheng Zhang and Taohong Hu

    Citation: Stem Cell Research & Therapy 2019 10:159

    Content type: Research

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  21. Ischemic diseases, which are caused by a reduction of blood supply that results in reduced oxygen transfer and nutrient uptake, are becoming the leading cause of disabilities and deaths. Therapeutic angiogenes...

    Authors: Xiaowei Bian, Kui Ma, Cuiping Zhang and Xiaobing Fu

    Citation: Stem Cell Research & Therapy 2019 10:158

    Content type: Review

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  22. Small nucleolar RNA host gene 3 (Snhg3) is a long non-coding RNA (lncRNA) that was shown to participate in the tumorigenesis of certain cancers. However, little is known about its role in embryonic stem cells ...

    Authors: Weisi Lu, Jianping Yu, Fengtao Shi, Jianing Zhang, Rui Huang, Shanshan Yin, Zhou Songyang and Junjiu Huang

    Citation: Stem Cell Research & Therapy 2019 10:157

    Content type: Research

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  23. Premature ovarian insufficiency (POI) is a common disease in reproductive women. The pathogenesis of POI is not clear, although it is known that it involves the disorder of oocyte differentiation and developme...

    Authors: Sheng Yang, Shufang Ding, Shiwei He, Lixia He, Kefei Gao, Shuping Peng and Cijun Shuai

    Citation: Stem Cell Research & Therapy 2019 10:156

    Content type: Research

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  24. Induced pluripotent stem cells (iPSCs) can generate epithelial stem cells (EpSCs) as seed cells for skin substitutes to repair skin defects. Here, we investigated the effects of a human acellular amniotic memb...

    Authors: Huateng Zhou, Lixiang Wang, Cui Zhang, Jintao Hu, Jianlin Chen, Weibin Du, Fei Liu, Weifan Ren, Jinfu Wang and Renfu Quan

    Citation: Stem Cell Research & Therapy 2019 10:155

    Content type: Research

    Published on:

  25. Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interactions and communication and stereotypical patterns of behaviors, interests, or activities. Even wit...

    Authors: Ruiyu Zhang, Yulong Cai, Rui Xiao, Hongyu Zhong, Xin Li, Lihe Guo, Haiwei Xu and Xiaotang Fan

    Citation: Stem Cell Research & Therapy 2019 10:153

    Content type: Research

    Published on:

  26. Allogeneic cardiac-derived progenitor cells (CPC) without immunosuppression could provide an effective ancillary therapy to improve cardiac function in reperfused myocardial infarction. We set out to perform a...

    Authors: Veronica Crisostomo, Claudia Baez, José Luis Abad, Belén Sanchez, Virginia Alvarez, Rosalba Rosado, Guadalupe Gómez-Mauricio, Olivier Gheysens, Virginia Blanco-Blazquez, Rebeca Blazquez, José Luis Torán, Javier G. Casado, Susana Aguilar, Stefan Janssens, Francisco M. Sánchez-Margallo, Luis Rodriguez-Borlado…

    Citation: Stem Cell Research & Therapy 2019 10:152

    Content type: Research

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  27. Epigenetic alteration is an important indicator of crosstalk between cancer cells and surrounding microenvironment components including mesenchymal stem cells (MSC). Human menstrual blood-derived stem cells (M...

    Authors: Yichen Wu, Xin Chen, Yongjia Zhao, Yanling Wang, Yifei Li and Charlie Xiang

    Citation: Stem Cell Research & Therapy 2019 10:151

    Content type: Research

    Published on:

  28. Heart failure (HF) is the end stage of most heart disease. Mesenchymal stem cells (MSCs), with their specific biological effects, have been applied in several clinical trials to evaluate the efficacy in HF the...

    Authors: Mengkang Fan, Yin Huang, Zhangwei Chen, Yan Xia, Ao Chen, Danbo Lu, Yuan Wu, Ning Zhang and Juying Qian

    Citation: Stem Cell Research & Therapy 2019 10:150

    Content type: Research

    Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:206

  29. Mesenchymal stem cells (MSCs) can migrate to tissue injury sites where they can induce multipotential differentiation and anti-inflammation effects to treat tissue injury. When traditional therapeutic methods ...

    Authors: Zhenxiong Ye, Wenfeng Lu, Lei Liang, Min Tang, Yunfeng Wang, Zhen Li, Heping Zeng, Aili Wang, Moubin Lin, Lei Huang, Hui Wang and Hai Hu

    Citation: Stem Cell Research & Therapy 2019 10:149

    Content type: Research

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  30. Intestinal stem cell transplantation has been shown to promote mucosal healing and to engender fully functional epithelium in experimental colitis. Hence, stem cell therapies may provide an innovative approach...

    Authors: Fredrik Bergenheim, Jakob B. Seidelin, Marianne Terndrup Pedersen, Benjamin E. Mead, Kim B. Jensen, Jeffrey M. Karp and Ole Haagen Nielsen

    Citation: Stem Cell Research & Therapy 2019 10:148

    Content type: Research

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  31. Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular diseases (CVD) and vascular health. Peripheral blood-derived CD34+ progenitor cells have been used as biomarker for CVD risk and m...

    Authors: Cleyton C. Domingues, Fiona J. Dore, Alexander Cho, Neeki Ahmadi, Yana Kropotova, Nabanita Kundu, Naji Younes, Vivek Jain and Sabyasachi Sen

    Citation: Stem Cell Research & Therapy 2019 10:147

    Content type: Research

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  32. Survival and therapeutic actions of bone marrow-derived mesenchymal stem cells (BMMSCs) can be limited by the hostile microenvironment present during acute spinal cord injury (SCI). Here, we investigated wheth...

    Authors: Kyan James Allahdadi, Thaís Alves de Santana, Girlaine Café Santos, Carine Machado Azevedo, Roberta Alves Mota, Carolina Kymie Nonaka, Daniela Nascimento Silva, Clarissa Xavier Resende Valim, Cláudio Pereira Figueira, Washington Luis Conrado dos Santos, Renan Fernandes do Espirito Santo, Afrânio Ferreira Evangelista, Cristiane Flora Villarreal, Ricardo Ribeiro dos Santos, Bruno Solano Freitas de Souza and Milena Botelho Pereira Soares

    Citation: Stem Cell Research & Therapy 2019 10:146

    Content type: Research

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  33. Glioblastoma (GBM) is the most common type of primary malignant brain tumor. Molecular hydrogen has been considered a preventive and therapeutic medical gas in many diseases including cancer. In our study, we ...

    Authors: Meng-yu Liu, Fei Xie, Yan Zhang, Ting-ting Wang, Sheng-nan Ma, Peng-xiang Zhao, Xin Zhang, Tyler W. Lebaron, Xin-long Yan and Xue-mei Ma

    Citation: Stem Cell Research & Therapy 2019 10:145

    Content type: Research

    Published on:

  34. Non-small cell lung cancer (NSCLC) is the second most prevalent cause of cancer-related fatality. Long non-coding RNAs (lncRNAs) have been observed to exercise functions in NSCLC. Here, the current study aimed...

    Authors: Peng Li, Wenqun Xing, Jinliang Xu, Dongfeng Yuan, Guanghui Liang, Baoxing Liu and Haibo Ma

    Citation: Stem Cell Research & Therapy 2019 10:144

    Content type: Research

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  35. Human adipose-derived mesenchymal progenitor cells (haMPCs) are stem cells with multiple differentiation potential and immunomodulatory function. Re-Join® comprises in vitro expanded haMPCs from adipose tissue...

    Authors: Liangjing Lu, Chengxiang Dai, Zhongwen Zhang, Hui Du, Suke Li, Ping Ye, Qiong Fu, Li Zhang, Xiaojing Wu, Yuru Dong, Yang Song, Dongbao Zhao, Yafei Pang and Chunde Bao

    Citation: Stem Cell Research & Therapy 2019 10:143

    Content type: Research

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  36. Angiogenesis, as an endogenous repair mechanism, plays crucial roles in wound healing and tissue regeneration. However, this process is impaired in the elderly due to aging-related vascular endothelial dysfunc...

    Authors: Bi Chen, Yongjin Sun, Juntao Zhang, Qingwei Zhu, Yunlong Yang, Xin Niu, Zhifeng Deng, Qing Li and Yang Wang

    Citation: Stem Cell Research & Therapy 2019 10:142

    Content type: Research

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  37. Visceral (VS) fat depot is known to have defective adipogenic functions compared to subcutaneous (SC) fat, but its mechanism of origin is unclear.

    Authors: Sandhya Sriram, Chengxiang Yuan, Smarajit Chakraborty, Winson Tay, Min Park, Asim Shabbir, Sue-Anne Toh, Weiping Han and Shigeki Sugii

    Citation: Stem Cell Research & Therapy 2019 10:141

    Content type: Short report

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  38. Peripheral arterial disease (PAD) is a common cause of disability and mortality. The reconstruction of blood circulation presents to be the key to treatment, which can be achieved by surgery and interventional...

    Authors: Wei Gao, Dawei Chen, Guanjian Liu and Xingwu Ran

    Citation: Stem Cell Research & Therapy 2019 10:140

    Content type: Research

    Published on:

  39. Nuclear factor-κB (NF-κB), an important transcription factor, participates in many physiological and pathological processes such as growth, differentiation, organogenesis, apoptosis, inflammation, and immune r...

    Authors: Yan Liang, Guoqing Chen, Yuzhi Yang, Ziyue Li, Tian Chen, Wenhua Sun, Mei Yu, Kuangwu Pan, Weihua Guo and Weidong Tian

    Citation: Stem Cell Research & Therapy 2019 10:139

    Content type: Research

    Published on:

  40. Allogeneic hematopoietic stem cell transplantation (AHSCT) is a curative therapeutic approach for different hematological malignancies (HMs), and epigenetic modifications, including DNA methylation, play a rol...

    Authors: Stefania Trino, Pietro Zoppoli, Angelo Michele Carella, Ilaria Laurenzana, Alessandro Weisz, Domenico Memoli, Giovanni Calice, Francesco La Rocca, Vittorio Simeon, Lucia Savino, Luigi Del Vecchio, Pellegrino Musto, Antonella Caivano and Luciana De Luca

    Citation: Stem Cell Research & Therapy 2019 10:138

    Content type: Research

    Published on:

  42. Human pluripotent stem cells (hPSCs) provide supplies of potential functional blood cells to suffice the clinical needs. However, the underlying mechanism of generating genuine hematopoietic stem cells (HSCs) ...

    Authors: Yv Wang, Jie Gao, Hongtao Wang, Mengge Wang, Yuqi Wen, Jiaojiao Guo, Pei Su, Lihong Shi, Wen Zhou and Jiaxi Zhou

    Citation: Stem Cell Research & Therapy 2019 10:136

    Content type: Research

    Published on:

  43. Xenotransplantation of spermatogonial stem cells (SSCs) has become a popular topic in various research fields because manipulating these cells can provide insights into the mechanisms associated with germ cell...

    Authors: Naira Caroline Godoy Pieri, Ana Carolina Furlanetto Mançanares, Aline Fernanda de Souza, Hugo Fernandes, Angela Maria Gonella Diaza, Fabiana Fernandes Bressan, Kelly Cristine Santos Roballo, Juliana Barbosa Casals, Mario Binelli, Carlos Eduardo Ambrósio and Daniele dos Santos Martins

    Citation: Stem Cell Research & Therapy 2019 10:135

    Content type: Research

    Published on:

  44. Concentrated growth factor (CGF), as a natural biomaterial, is known to contain platelets, cytokines, and growth factors to facilitate the healing process, but there has been little information acquired in reg...

    Authors: Fangfang Xu, Lu Qiao, Yumei Zhao, Weiting Chen, Shebing Hong, Jing Pan and Beizhan Jiang

    Citation: Stem Cell Research & Therapy 2019 10:134

    Content type: Research

    Published on:

  45. Delivery of endothelial cells into the ischemic tissue is emerging as an alternative approach in revascularization of injured tissues by means of angiogenesis to restore organ function. Adipose-derived stem ce...

    Authors: Ting Shang, Shuaijun Li, Yun Zhang, Laiya Lu, Lei Cui and Fang Fang Guo

    Citation: Stem Cell Research & Therapy 2019 10:133

    Content type: Research

    Published on:

  46. The original article [1] contained an error in the presentation of the first author’s name, Nádia de Cássia Noronha. This has now been corrected.

    Authors: Nádia de Cássia Noronha, Amanda Mizukami, Carolina Caliári-Oliveira, Juçara Gastaldi Cominal, José Lucas M. Rocha, Dimas Tadeu Covas, Kamilla Swiech and Kelen C. R. Malmegrim

    Citation: Stem Cell Research & Therapy 2019 10:132

    Content type: Correction

    Published on:

    The original article was published in Stem Cell Research & Therapy 2019 10:131

  47. Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based therapy of immune-mediated, inflammatory, and degenerative diseases, due to their immunosuppressive, immunomodulatory, and r...

    Authors: Nádia de Cássia Noronha, Amanda Mizukami, Carolina Caliári-Oliveira, Juçara Gastaldi Cominal, José Lucas M. Rocha, Dimas Tadeu Covas, Kamilla Swiech and Kelen C. R. Malmegrim

    Citation: Stem Cell Research & Therapy 2019 10:131

    Content type: Review

    Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:132

  48. Pluripotent stem cells are attractive progenitor cells for the generation of erythroid cells in vitro as have expansive proliferative potential. However, although embryonic (ESC) and induced pluripotent (iPSC)...

    Authors: Kongtana Trakarnsanga, Daniel Ferguson, Deborah E. Daniels, Rebecca E. Griffiths, Marieangela C. Wilson, Kathryn E. Mordue, Abi Gartner, Tatyana N. Andrienko, Annabel Calvert, Alison Condie, Angela McCahill, Joanne C. Mountford, Ashley M. Toye, David J. Anstee and Jan Frayne

    Citation: Stem Cell Research & Therapy 2019 10:130

    Content type: Research

    Published on:

  49. Poor cell engraftment and survival after transplantation limited the application of stem cell therapy. Synthetic biomaterials could provide an artificial microenvironment for stem cells, thereby improve cell s...

    Authors: Nianhuan Zhao, Zhiwei Yue, Jian Cui, Yong Yao, Xianghe Song, Bangping Cui, Xin Qi, Zhibo Han, Zhong-Chao Han, Zhikun Guo, Zuo-Xiang He and Zongjin Li

    Citation: Stem Cell Research & Therapy 2019 10:129

    Content type: Research

    Published on:

  50. Odontoblast is a unique progenitor that plays a role in dentin formation. So far, the dentinogenic differentiation of dental pulp stem cells and the role of surface molecules of odontoblasts in dentinogenesis ...

    Authors: Kyung-Jung Kang, Chun-Jeih Ryu and Young-Joo Jang

    Citation: Stem Cell Research & Therapy 2019 10:128

    Content type: Research

    Published on:

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