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  1. Content type: Research

    Aging is one of the key factors that regulate the function of human bone marrow mesenchymal stem cells (hBM-MSCs) and related changes in microRNA (miRNA) expression. However, data reported on aging-related miR...

    Authors: Jun Dong, Zhenhui Zhang, Hongshen Huang, Pei Mo, Chuanfan Cheng, Jianwei Liu, Weizhao Huang, Chaowei Tian, Chongyu Zhang and Jiao Li

    Citation: Stem Cell Research & Therapy 2018 9:151

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  2. Content type: Research

    Although typically cultured at an atmospheric oxygen concentration (20–21%), adipose-derived stem cells (ASCs) reside under considerable low oxygen tension (physioxia) in vivo. In the present study, we explore...

    Authors: Chang Chen, Qi Tang, Yan Zhang, Mei Yu, Wei Jing and Weidong Tian

    Citation: Stem Cell Research & Therapy 2018 9:148

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  3. Content type: Research

    Human induced pluripotent stem cells-derived mesenchymal stem cells (iPSC-MSCs) have been shown to be effective in Type 2 helper T cells (Th2)-dominant eosinophilic allergic airway inflammation. However, the r...

    Authors: Shu-Bin Fang, Hong-Yu Zhang, Ai-Yun Jiang, Xing-Liang Fan, Yong-Dong Lin, Cheng-Lin Li, Cong Wang, Xiang-Ci Meng and Qing-Ling Fu

    Citation: Stem Cell Research & Therapy 2018 9:147

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  4. Content type: Research

    Endometrial regenerative cells (ERCs), a novel type of mesenchymal-like stem cell derived from menstrual blood, have been recently evaluated as an attractive candidate source in ulcerative colitis (UC); howeve...

    Authors: Xiaoxi Xu, Yong Wang, Baoren Zhang, Xu Lan, Shanzheng Lu, Peng Sun, Xiang Li, Ganggang Shi, Yiming Zhao, Hongqiu Han, Caigan Du and Hao Wang

    Citation: Stem Cell Research & Therapy 2018 9:146

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  5. Content type: Research

    The ability of mesenchymal stem cells (MSCs) to migrate to the desired tissues or lesions is crucial for stem cell-based regenerative medicine and tissue engineering. Optimal therapeutics for promoting MSC mig...

    Authors: Yingchi Zhang, Jiyuan Yan, Haoran Xu, Yong Yang, Wenkai Li, Hua Wu and Chaoxu Liu

    Citation: Stem Cell Research & Therapy 2018 9:143

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  6. Content type: Research

    Multiple myeloma (MM) currently remains largely incurable. Cancer stem cells (CSCs) are believed to be responsible for drug resistance and eventual relapse. In this study, we exploited a novel agent to evaluat...

    Authors: Fangfang Shi, Miao Li, Jing Wang, Di Wu, Meng Pan, Mei Guo and Jun Dou

    Citation: Stem Cell Research & Therapy 2018 9:144

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  7. Content type: Research

    Most common forms of hair loss (alopecia) are caused by aberrant hair follicle cycling and changes in hair follicle morphology. However, current treatments for alopecia do not specifically target these process...

    Authors: Rami Anderi, Nehman Makdissy, Albert Azar, Francine Rizk and Aline Hamade

    Citation: Stem Cell Research & Therapy 2018 9:141

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  8. Content type: Research

    Due to their extensive self-renewal and multilineage differentiation capacity, human embryonic stem cells (hESCs) have great potential for studying developmental biology, disease modeling, and developing cell ...

    Authors: Chuti Laowtammathron, Pimjai Chingsuwanrote, Roungsin Choavaratana, Suphadtra Phornwilardsiri, Ketsara Sitthirit, Chidchanok Kaewjunun, Orawan Makemaharn, Papussorn Terbto, Supaporn Waeteekul, Chanchao Lorthongpanich, Yaowalak U-pratya, Pimonwan Srisook, Pakpoom Kheolamai and Surapol Issaragrisil

    Citation: Stem Cell Research & Therapy 2018 9:138

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  9. Content type: Research

    Peripheral nerve injury (PNI) is a worldwide issue associated with severe social and economic burden. Autologous nerve grafting, the gold standard treatment for peripheral nerve defects, still has a number of ...

    Authors: Xun Sun, Yun Zhu, He-yong Yin, Zhi-yuan Guo, Feng Xu, Bo Xiao, Wen-li Jiang, Wei-min Guo, Hao-ye Meng, Shi-bi Lu, Yu Wang and Jiang Peng

    Citation: Stem Cell Research & Therapy 2018 9:133

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  10. Content type: Research

    Ischemic stroke causes a multitude of brain damage. Neurovascular injury and myelin sheath degradation are two manifestations of ischemic brain damage. Therapeutic strategies aiming only at repairing the neura...

    Authors: Yaning Li, Shuang Chang, Wanlu Li, Guanghui Tang, Yuanyuan Ma, Yanqun Liu, Fang Yuan, Zhijun Zhang, Guo-Yuan Yang and Yongting Wang

    Citation: Stem Cell Research & Therapy 2018 9:139

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  11. Content type: Research

    A variety of neurological disorders including neurodegenerative diseases and infection by neurotropic viruses can cause structural and functional changes in the central nervous system (CNS), resulting in long-...

    Authors: Leonardo D’Aiuto, Jennifer Naciri, Nicholas Radio, Sesha Tekur, Dennis Clayton, Gerard Apodaca, Roberto Di Maio, Yun Zhi, Peter Dimitrion, Paolo Piazza, Matthew Demers, Joel Wood, Charleen Chu, Jason Callio, Lora McClain, Robert Yolken…

    Citation: Stem Cell Research & Therapy 2018 9:134

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  12. Content type: Research

    The subcellular distribution of prorenin receptor and adaptor protein ATP6AP2 may affect neurogenesis. In this study, we hypothesized that ATP6AP2 expression and subcellular relocalization from caveolae/lipid ...

    Authors: Nehman Makdissy, Katia Haddad, Jeanne D’arc AlBacha, Diana Chaker, Bassel Ismail, Albert Azar, Ghada Oreibi, David Ayoub, Ibrahim Achkar, Didier Quilliot and Ziad Fajloun

    Citation: Stem Cell Research & Therapy 2018 9:132

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  13. Content type: Method

    The stromal vascular fraction (SVF) derived from adipose tissue contains adipose-derived stromal/stem cells (ASC) and can be used for regenerative applications. Thus, a validated protocol for SVF isolation, fr...

    Authors: Francesco Agostini, Francesca Maria Rossi, Donatella Aldinucci, Monica Battiston, Elisabetta Lombardi, Stefania Zanolin, Samuele Massarut, Pier Camillo Parodi, Alessandro Da Ponte, Giovanni Tessitori, Barbara Pivetta, Cristina Durante and Mario Mazzucato

    Citation: Stem Cell Research & Therapy 2018 9:130

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  14. Content type: Research

    Differentiation of human induced pluripotent stem cells (hiPSCs) into retinal lineages offers great potential for medical application. Therefore, it is of crucial importance to know the key intrinsic regulator...

    Authors: Jen-Hua Chuang, Aliaksandr A. Yarmishyn, De-Kuang Hwang, Chih-Chien Hsu, Mong-Lien Wang, Yi-Ping Yang, Ke-Hung Chien, Shih-Hwa Chiou, Chi-Hsien Peng and Shih-Jen Chen

    Citation: Stem Cell Research & Therapy 2018 9:140

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  15. Content type: Research

    Spinal cord injuries (SCIs) are sustained by an increasing number of patients each year worldwide. The treatment of SCIs has long been a hard nut to crack for doctors around the world. Mesenchymal stem cells (...

    Authors: Chaohua Yang, Gaoju Wang, Fenfen Ma, Baoqing Yu, Fancheng Chen, Jin Yang, Jianjun Feng and Qing Wang

    Citation: Stem Cell Research & Therapy 2018 9:136

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  16. Content type: Research

    Multipotent mesenchymal stromal cell (MSC) therapy has been widely recognized as a feasible strategy for regenerating injured myocardial tissue. However, little is known about the efficacy of intravenous injec...

    Authors: Meikuang Lim, Weiqiang Wang, Lu Liang, Zhi-bo Han, Zongjin Li, Jie Geng, Meng Zhao, Honghong Jia, Jie Feng, Zhe Wei, Baoquan Song, Jiemin Zhang, Jun Li, Tianwen Liu, Fan Wang, Ting Li…

    Citation: Stem Cell Research & Therapy 2018 9:129

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  17. Content type: Research

    Adult mesenchymal stem cells (MSCs) hold great promise for regenerative medicine because of their self-renewal, multipotency, and trophic and immunosuppressive effects. Due to the rareness and high heterogenei...

    Authors: Yueh-Hsun Kevin Yang, Courtney R. Ogando, Carmine Wang See, Tsui-Yun Chang and Gilda A. Barabino

    Citation: Stem Cell Research & Therapy 2018 9:131

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  18. Content type: Research

    Adult mesenchymal stem cells (MSCs) play a crucial role in the maintenance of tissue homeostasis and in regenerative processes. Among the different MSC types, the gingiva-derived mesenchymal stem cells (GMSCs)...

    Authors: Chiara Giacomelli, Letizia Natali, Marco Nisi, Marinella De Leo, Simona Daniele, Barbara Costa, Filippo Graziani, Mario Gabriele, Alessandra Braca, M. Letizia Trincavelli and Claudia Martini

    Citation: Stem Cell Research & Therapy 2018 9:135

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  19. Content type: Research

    Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal cells currently tested for multiple therapeutic purposes. Their potential to home into tumors, to secrete trophic/vasculogenic factors, and t...

    Authors: Flavia Bruna, Anita Plaza, Martha Arango, Iris Espinoza and Paulette Conget

    Citation: Stem Cell Research & Therapy 2018 9:137

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  20. Content type: Research

    Synovial mesenchymal stem cells (MSCs) are an attractive cell source for cartilage and meniscus regeneration. Synovial tissue can be histologically classified into three regions; surface, stromal and perivascu...

    Authors: Mitsuru Mizuno, Hisako Katano, Yo Mabuchi, Yusuke Ogata, Shizuko Ichinose, Shizuka Fujii, Koji Otabe, Keiichiro Komori, Nobutake Ozeki, Hideyuki Koga, Kunikazu Tsuji, Chihiro Akazawa, Takeshi Muneta and Ichiro Sekiya

    Citation: Stem Cell Research & Therapy 2018 9:123

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  21. Content type: Research

    Although adult human tissue-derived epidermal stem cells are capable of differentiating into enamel-secreting ameloblasts and forming teeth with regenerated enamel when recombined with mouse dental mesenchyme ...

    Authors: Xuefeng Hu, Jyh-Wei Lee, Xi Zheng, Junhua Zhang, Xin Lin, Yingnan Song, Bingmei Wang, Xiaoxiao Hu, Hao-Hueng Chang, Yiping Chen, Chun-Pin Lin and Yanding Zhang

    Citation: Stem Cell Research & Therapy 2018 9:126

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  22. Content type: Research

    The use of platelet lysate (PL) for the ex-vivo expansion of mesenchymal stromal/stem cells (MSCs) was initially proposed by Doucet et al. in 2005, as an alternative to animal serum. Moreover, regulatory autho...

    Authors: Valentina Becherucci, Luisa Piccini, Serena Casamassima, Silvia Bisin, Valentina Gori, Francesca Gentile, Riccardo Ceccantini, Elena De Rienzo, Barbara Bindi, Paola Pavan, Vanessa Cunial, Elisa Allegro, Stefano Ermini, Francesca Brugnolo, Giuseppe Astori and Franco Bambi

    Citation: Stem Cell Research & Therapy 2018 9:124

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  23. Content type: Research

    Adipose-derived stem cells (ASCs) that show multidifferentiation and anti-immune rejection capacities have been widely used in plastic and reconstructive surgery. Previous studies have indicated that mechanica...

    Authors: Yiting Yang, Rongmei Qu, Tingyu Fan, Xi Zhu, Yanting Feng, Yuchao Yang, Ting Deng, Yan Peng, Wenhua Huang, Jun Ouyang and Jingxing Dai

    Citation: Stem Cell Research & Therapy 2018 9:125

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  24. Content type: Research

    We have previously demonstrated that acidic preconditioning of human endothelial colony-forming cells (ECFC) increased proliferation, migration, and tubulogenesis in vitro, and increased their regenerative pot...

    Authors: Hebe Agustina Mena, Paula Romina Zubiry, Blandine Dizier, Mirta Schattner, Catherine Boisson-Vidal and Soledad Negrotto

    Citation: Stem Cell Research & Therapy 2018 9:120

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  25. Content type: Research

    Canine MuStem cells have demonstrated regenerative efficacy in a dog model of muscular dystrophy, and the recent characterization of human counterparts (hMuStem) has highlighted the therapeutic potential of th...

    Authors: Charlotte Saury, Aurélie Lardenois, Cindy Schleder, Isabelle Leroux, Blandine Lieubeau, Laurent David, Marine Charrier, Laëtitia Guével, Sabrina Viau, Bruno Delorme and Karl Rouger

    Citation: Stem Cell Research & Therapy 2018 9:128

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  26. Content type: Research

    Adult bone marrow contains stem cells that replenish the myeloid and lymphoid lineages. A subset of human and mouse CD34+ bone marrow stem cells can be propagated in culture to autonomously express embryonic stem...

    Authors: Tapas Makar, Vamshi K. Nimmagadda, Poornachander R. Guda, Brian Hampton, Weiliang Huang, Maureen A. Kane, Paul S. Fishman, Bernard Pessac, Christopher T. Bever Jr. and David Trisler

    Citation: Stem Cell Research & Therapy 2018 9:127

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  27. Content type: Research

    Bone marrow-derived allogeneic mesenchymal stem cells (MSCs) from young healthy donors are immunoprivileged and their clinical application for regenerative medicine is under evaluation. However, data from prec...

    Authors: Niketa Sareen, Glen Lester Sequiera, Rakesh Chaudhary, Ejlal Abu-El-Rub, Subir Roy Chowdhury, Vikram Sharma, Arun Surendran, Meenal Moudgil, Paul Fernyhough, Amir Ravandi and Sanjiv Dhingra

    Citation: Stem Cell Research & Therapy 2018 9:121

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  28. Content type: Research

    Critical tissues that undergo regeneration in periodontal tissue are of mesenchymal origin; thus, investigating the regulatory mechanisms underlying the fate of periodontal ligament stem cells could be benefic...

    Authors: Shan Yang, Lijia Guo, Yingying Su, Jing Wen, Juan Du, Xiaoyan Li, Yitong Liu, Jie Feng, Yongmei Xie, Yuxing Bai, Hao Wang and Yi Liu

    Citation: Stem Cell Research & Therapy 2018 9:118

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  29. Content type: Review

    α6-Integrin subunit (also known as CD49f) is a stemness signature that has been found on the plasma membrane of more than 30 stem cell populations. A growing body of studies have focused on the critical role o...

    Authors: Zijing Zhou, Jing Qu, Li He, Hong Peng, Ping Chen and Yong Zhou

    Citation: Stem Cell Research & Therapy 2018 9:122

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  30. Content type: Research

    Red blood cells are the most abundant cells in the blood that deliver oxygen to the whole body. Erythropoietin (EPO), a positive regulator of erythropoiesis, is currently the major treatment for chronic anemia...

    Authors: Tzu-Lin Chen, Ya-Wen Chiang, Guan-Ling Lin, Hsin-Hou Chang, Te-Sheng Lien, Min-Hua Sheh and Der-Shan Sun

    Citation: Stem Cell Research & Therapy 2018 9:119

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  31. Content type: Research

    We recently demonstrated that autologous transplantation of mobilized dental pulp stem cells (MDPSCs) was a safe and efficacious potential therapy for total pulp regeneration in a clinical study. The autologou...

    Authors: Koichiro Iohara, Shinji Utsunomiya, Sakae Kohara and Misako Nakashima

    Citation: Stem Cell Research & Therapy 2018 9:116

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  32. Content type: Research

    Employing growth factor-induced partial reprogramming in vitro, peripheral human blood monocytes can acquire a state of plasticity along with expression of various markers of pluripotency. These so-called prog...

    Authors: Rouven Berndt, Lars Hummitzsch, Katharina Heß, Martin Albrecht, Karina Zitta, Rene Rusch, Beke Sarras, Andreas Bayer, Jochen Cremer, Fred Faendrich and Justus Groß

    Citation: Stem Cell Research & Therapy 2018 9:117

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  33. Content type: Research

    DNA topoisomerase IIβ (topo IIβ) is known to regulate neural differentiation by inducing the neuronal genes responsible for critical neural differentiation events such as neurite outgrowth and axon guidance. H...

    Authors: Merve Zaim and Sevim Isik

    Citation: Stem Cell Research & Therapy 2018 9:114

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  34. Content type: Research

    Established therapies for managing kidney dysfunction such as kidney dialysis and transplantation are limited due to the shortage of compatible donated organs and high costs. Stem cell-based therapies are curr...

    Authors: Md Shaifur Rahman, Lucas-Sebastian Spitzhorn, Wasco Wruck, Carsten Hagenbeck, Percy Balan, Nina Graffmann, Martina Bohndorf, Audrey Ncube, Pascale V. Guillot, Tanja Fehm and James Adjaye

    Citation: Stem Cell Research & Therapy 2018 9:113

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  35. Content type: Commentary

    In the study by Sarveazad et al. adipose tissue-derived stem cells were injected to reinforce anal sphincter repair. The authors came to the conclusion that injection of stem cells during repair surgery for fe...

    Authors: Mohammed Mohammed El-Said and Sameh Hany Emile

    Citation: Stem Cell Research & Therapy 2018 9:115

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    The original article was published in Stem Cell Research & Therapy 2017 8:40

  36. Content type: Review

    The production of veritable in-vitro models of bone tissue is essential to understand the biology of bone and its surrounding environment, to analyze the pathogenesis of bone diseases (e.g., osteoporosis, oste...

    Authors: Alessandro Pirosa, Riccardo Gottardi, Peter G. Alexander and Rocky S. Tuan

    Citation: Stem Cell Research & Therapy 2018 9:112

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  37. Content type: Research

    Silicosis has been topping the list of high-incidence occupational diseases in developing countries and cannot be completely cured. Recent advances in stem cell research have made possible the treatment of var...

    Authors: Shangya Chen, Guanqun Cui, Cheng Peng, Martin F. Lavin, Xiaoying Sun, Enguo Zhang, Ye Yang, Yingjun Guan, Zhongjun Du and Hua Shao

    Citation: Stem Cell Research & Therapy 2018 9:110

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  38. Content type: Research

    Currently, the overall therapeutic efficiency of mesenchymal stem cells (MSCs) transplantation for the treatment of cardiovascular disease is not satisfactory. The low viability and angiogenic capacity of the ...

    Authors: Jingying Hou, Lingyun Wang, Quanhua Wu, Guanghui Zheng, Huibao Long, Hao Wu, Changqing Zhou, Tianzhu Guo, Tingting Zhong, Lei Wang, Xuxiang Chen and Tong Wang

    Citation: Stem Cell Research & Therapy 2018 9:109

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  39. Content type: Correction

    The original article [1] mistakenly omitted a source of funding, and the authors would like to rectify this by acknowledging the additional support of the Natural Science Foundation in Jiangsu Province (BK2015...

    Authors: Zhaoyu Lin, Fei Liu, Peiliang Shi, Anying Song, Zan Huang, Dayuan Zou, Qin Chen, Jianxin Li and Xiang Gao

    Citation: Stem Cell Research & Therapy 2018 9:111

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    The original article was published in Stem Cell Research & Therapy 2018 9:47

  40. Content type: Short report

    Senolytic drugs are thought to target senescent cells and might thereby rejuvenate tissues. In fact, such compounds were suggested to increase health and lifespan in various murine aging models. So far, effect...

    Authors: Clara Grezella, Eduardo Fernandez-Rebollo, Julia Franzen, Mónica Sofia Ventura Ferreira, Fabian Beier and Wolfgang Wagner

    Citation: Stem Cell Research & Therapy 2018 9:108

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  41. Content type: Research

    Platelet-rich plasma (PRP) is an autologous blood product that contains a high concentration of several growth factors. Platelet-derived growth factor (PDGF)-BB is a potential mitogen for human adipose-derived...

    Authors: Fangyuan Lai, Natsuko Kakudo, Naoki Morimoto, Shigeru Taketani, Tomoya Hara, Takeshi Ogawa and Kenji Kusumoto

    Citation: Stem Cell Research & Therapy 2018 9:107

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  42. Content type: Research

    The role of bone tissue engineering in the field of regenerative medicine has been a main research topic over the past few years. There has been much interest in the use of three-dimensional (3D) engineered sc...

    Authors: Francesca Diomede, Agnese Gugliandolo, Paolo Cardelli, Ilaria Merciaro, Valeria Ettorre, Tonino Traini, Rossella Bedini, Domenico Scionti, Alessia Bramanti, Antonio Nanci, Sergio Caputi, Antonella Fontana, Emanuela Mazzon and Oriana Trubiani

    Citation: Stem Cell Research & Therapy 2018 9:104

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  43. Content type: Review

    Damage of mitochondria in the initial period of tissue injury aggravates the severity of injury. Restoration of mitochondria dysfunction and mitochondrial-based therapeutics represent a potentially effective t...

    Authors: Jingyu Wang, Heyangzi Li, Ying Yao, Tengfei Zhao, Ying-ying Chen, Yue-liang Shen, Lin-lin Wang and Yongjian Zhu

    Citation: Stem Cell Research & Therapy 2018 9:106

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  44. Content type: Review

    The fibrocyte, which was first described in 1994, is a type of circulating mesenchymal progenitor cell in the peripheral blood. Fibrocytes play important roles in chronic inflammation, wound healing, tissue re...

    Authors: Feng Zhang, Ke Liu, Han Zhao and Yan He

    Citation: Stem Cell Research & Therapy 2018 9:105

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  45. Content type: Research

    White smoke inhalation (WSI) is an uncommon but potentially deadly cause of acute lung injury and acute respiratory distress syndrome for which no effective pharmaceutical treatment has been developed. This st...

    Authors: Pei Cui, Haiming Xin, Yongming Yao, Shichu Xiao, Feng Zhu, Zhenyu Gong, Zhiping Tang, Qiu Zhan, Wei Qin, Yanhua Lai, Xiaohui Li, Yalin Tong and Zhaofan Xia

    Citation: Stem Cell Research & Therapy 2018 9:101

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  46. Content type: Research

    Understanding stem cell behavior as a delivery tool in cancer therapy is essential for evaluating their future clinical potential. Previous in-vivo studies proved the use of mesenchymal stem cells (MSCs) for l...

    Authors: Hamideh Salehi, Siham Al-Arag, Elodie Middendorp, Csilla Gergely, Frederic Cuisinier and Valerie Orti

    Citation: Stem Cell Research & Therapy 2018 9:103

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  47. Content type: Research

    Human decidua parietalis mesenchymal stem/multipotent stromal cells (DPMSCs) have unique phenotypic and functional properties that make them promising candidates for cell-based therapy. Here, we investigated DPMS...

    Authors: M. H. Abumaree, E. Bahattab, A. Alsadoun, A. Al Dosaimani, F. M. Abomaray, T. Khatlani, B. Kalionis, M. F. El-Muzaini, A. O. Alawad and A. S. AlAskar

    Citation: Stem Cell Research & Therapy 2018 9:102

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