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  1. Transplantation of neural stem cells (NSCs) is increasingly suggested to become part of future therapeutic approaches to improve functional outcome of various central nervous system disorders. However, recentl...

    Authors: Kristien Reekmans, Nathalie De Vocht, Jelle Praet, Erik Fransen, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Herman Goossens, Annemie Van der Linden, Zwi Berneman and Peter Ponsaerts
    Citation: Stem Cell Research & Therapy 2012 3:56
  2. One of the most challenging safety issues in the manufacture of cell based medicinal products is the control of microbial risk as cell-based products cannot undergo terminal sterilization. Accordingly, sensiti...

    Authors: Mika Pietilä, Kaarina Lähteenmäki, Siri Lehtonen, Hannu-Ville Leskelä, Marko Närhi, Maarit Lönnroth, Jaana Mättö, Petri Lehenkari and Katrina Nordström
    Citation: Stem Cell Research & Therapy 2012 3:53
  3. We previously found that mesenchymal stem cells (MSCs) injected intravenously could attenuate peritoneal adhesion by secreting tumor necrosis alpha-stimulating gene (TSG)-6, while MSCs injected intraperitoneal...

    Authors: Nan Wang, Yeqing Shao, Yan Mei, Li Zhang, Qinggang Li, Diangeng Li, Suozhu Shi, Quan Hong, Hongli Lin and Xiangmei Chen
    Citation: Stem Cell Research & Therapy 2012 3:51
  4. This prospective cohort study aimed to assess the influence of stem cell therapy (SCT) on health-related quality of life (HRQOL) by using the SF-36 v2 and to elucidate the influence of objective clinical varia...

    Authors: Hosny Salama, Abdel-Rahamn N Zekri, Rasha Ahmed, Iman Medhat, El Sayed Abdallah, Tarneem Darwish, Ola S Ahmed and Abeer Bahnassy
    Citation: Stem Cell Research & Therapy 2012 3:49
  5. Bone marrow mesenchymal stem cells (BM-MSCs) are multipotent cells that can differentiate into different cell lineages and have emerged as a promising tool for cell-targeted therapies and tissue engineering. T...

    Authors: Serena Redaelli, Angela Bentivegna, Dana Foudah, Mariarosaria Miloso, Juliana Redondo, Gabriele Riva, Simona Baronchelli, Leda Dalprà and Giovanni Tredici
    Citation: Stem Cell Research & Therapy 2012 3:47
  6. Controlled expansion and differentiation of pluripotent stem cells (PSCs) using reproducible, high-throughput methods could accelerate stem cell research for clinical therapies. Hydrodynamic culture systems fo...

    Authors: Krista M Fridley, Melissa A Kinney and Todd C McDevitt
    Citation: Stem Cell Research & Therapy 2012 3:45
  7. The assembly of cells into tissues is a complex process controlled by numerous signaling pathways to ensure the fidelity of the final structure. Tissue assembly is also very dynamic, as exemplified by the form...

    Authors: Sriram Manivannan and Celeste M Nelson
    Citation: Stem Cell Research & Therapy 2012 3:42
  8. Stem cells interact with biochemical and biophysical signals in their extracellular environment. The biophysical signals are transduced to the stem cells either through the underlying extracellular matrix or e...

    Authors: Evelyn KF Yim and Michael P Sheetz
    Citation: Stem Cell Research & Therapy 2012 3:41
  9. Induced pluripotent stem cells (iPSCs) are a potent cell source for neurogenesis. Previously we have generated iPSCs from human dental stem cells carrying transgene vectors. These exogenous transgenes may affe...

    Authors: Xiao-Ying Zou, Hsiao-Ying Yang, Zongdong Yu, Xiao-Bing Tan, Xing Yan and George T-J Huang
    Citation: Stem Cell Research & Therapy 2012 3:43
  10. Bone marrow mesenchymal stem cells (BMMSCs) are a heterogeneous population of postnatal precursor cells with the capacity of adhering to culture dishes generating colony-forming unit-fibroblasts (CFU-F). Here ...

    Authors: Kentaro Akiyama, Yong-Ouk You, Takayoshi Yamaza, Chider Chen, Liang Tang, Yan Jin, Xiao-Dong Chen, Stan Gronthos and Songtao Shi
    Citation: Stem Cell Research & Therapy 2012 3:40
  11. X-linked adrenoleukodystrophy (X-ALD) is a complex disorder with variable expressivity that affects the nervous, adrenocortical and male reproductive systems. Although ABCD1 mutations are known to provide the gen...

    Authors: Xiao-Ming Wang, Wing Yan Yik, Peilin Zhang, Wange Lu, Patricia K Dranchak, Darryl Shibata, Steven J Steinberg and Joseph G Hacia
    Citation: Stem Cell Research & Therapy 2012 3:39
  12. Cellular therapy products are an emerging medical product class undergoing rapid scientific and clinical innovation worldwide. These products pose unique regulatory challenges both for countries with existing ...

    Authors: Judith A Arcidiacono, Joan W Blair and Kimberly A Benton
    Citation: Stem Cell Research & Therapy 2012 3:38
  13. Therapeutic strategies using stem cells for treating neurological diseases are receiving more attention as the scientific community appreciates cell-autonomous contributions to several diseases of the central ...

    Authors: Akshata A Almad and Nicholas J Maragakis
    Citation: Stem Cell Research & Therapy 2012 3:37
  14. A number of questions remain unanswered in the field of cell therapy for acute myocardial infarction, including what is the optimal cell type, and can therapeutic efficacy be enhanced by conditioning regimens....

    Authors: Aidan Flynn, Xizhe Chen, Enda O'Connell and Timothy O'Brien
    Citation: Stem Cell Research & Therapy 2012 3:36
  15. The recent derivation of disease-specific induced pluripotent stem cells (iPSCs) from somatic cells of patients with familial and sporadic forms of diseases and the demonstration of their ability to give rise ...

    Authors: Hsiang-Po Huang, Ching-Yu Chuang and Hung-Chih Kuo
    Citation: Stem Cell Research & Therapy 2012 3:34
  16. Adipose stem cells (ASCs) secrete many trophic factors that can stimulate tissue repair, including angiogenic factors, but little is known about how ASCs and their secreted factors influence cartilage regenera...

    Authors: Christopher SD Lee, Olivia A Burnsed, Vineeth Raghuram, Jonathan Kalisvaart, Barbara D Boyan and Zvi Schwartz
    Citation: Stem Cell Research & Therapy 2012 3:35
  17. Ischaemia-related diseases such as peripheral artery disease and coronary heart disease constitute a major issue in medicine as they affect millions of individuals each year and represent a considerable econom...

    Authors: Christina L O'Neill, Michelle T O'Doherty, Sarah EJ Wilson, Amer A Rana, Claire E Hirst, Alan W Stitt and Reinhold J Medina
    Citation: Stem Cell Research & Therapy 2012 3:31
  18. The adult mammalian brain retains niches for neural stem cells (NSCs), which can generate glial and neuronal components of the brain tissue. However, it is barely established how chronic neuroinflammation, as ...

    Authors: Maik MA Worlitzer, Eva C Bunk, Kathrin Hemmer and Jens C Schwamborn
    Citation: Stem Cell Research & Therapy 2012 3:33
  19. The influence of genetic background on the ability to generate induced pluripotent stem cells (iPSCs) has the potential to impact future applications, but has yet to be examined in detail. The purpose of this ...

    Authors: Lauren V Schnabel, Christian M Abratte, John C Schimenti, Teresa L Southard and Lisa A Fortier
    Citation: Stem Cell Research & Therapy 2012 3:30
  20. Embryonic stem cells (ESCs) provide an attractive cell source for basic research and disease treatment. Currently, the common culture system for mouse ESC requires mouse embryonic fibroblast (MEF) as a feeder ...

    Authors: Yu Ma, Junjie Gu, Chunliang Li, Xiaoyuan Wei, Fan Tang, Guilai Shi, Jing Jiang, Ying Kuang, Jinsong Li, Zhugang Wang, Xin Xie and Ying Jin
    Citation: Stem Cell Research & Therapy 2012 3:29
  21. The remarkable speed with which the field of stem cell biology has evolved is unprecedented and has already changed the way we do science. In this series of articles we have invited leading experts to present ...

    Authors: Mahendra Rao
    Citation: Stem Cell Research & Therapy 2012 3:27
  22. Aastrom Biosciences has developed a proprietary cell-processing technology that enables the manufacture of ixmyelocel-T, a patient-specific multicellular therapy expanded from a small sample of a patient's own...

    Authors: Ronnda L Bartel, Caryn Cramer, Kelly Ledford, Amy Longcore, Christopher Parrish, Theresa Stern, Sharon Watling and Frank Zeigler
    Citation: Stem Cell Research & Therapy 2012 3:26
  23. Osteoarthritis (OA) is a degenerative disease of the connective tissue and progresses with age in the older population or develops in young athletes following sports-related injury. The articular cartilage is ...

    Authors: Pawan K Gupta, Anjan K Das, Anoop Chullikana and Anish S Majumdar
    Citation: Stem Cell Research & Therapy 2012 3:25
  24. Injury and disease of the spinal cord are generally met with a poor prognosis. This poor prognosis is due not only to the characteristics of the diseases but also to our poor ability to deliver therapeutics to...

    Authors: Eleanor M Donnelly, Jason Lamanna and Nicholas M Boulis
    Citation: Stem Cell Research & Therapy 2012 3:24
  25. Endothelial progenitor cells (EPC) capable of initiating or augmenting vascular growth were recently identified within the small population of CD34-expressing cells that circulate in human peripheral blood and...

    Authors: G Robin Barclay, Olga Tura, Kay Samuel, Patrick WF Hadoke, Nicholas L Mills, David E Newby and Marc L Turner
    Citation: Stem Cell Research & Therapy 2012 3:23
  26. Transplantation of genetically modified human bone marrow-derived mesenchymal stem cells (hMSCs) with an accurate potential for chondrogenic differentiation may be a powerful means to enhance the healing of ar...

    Authors: Jagadeesh K Venkatesan, Myriam Ekici, Henning Madry, Gertrud Schmitt, Dieter Kohn and Magali Cucchiarini
    Citation: Stem Cell Research & Therapy 2012 3:22
  27. Ageing is a biological certainty for all living organisms, and is due to the loss of tissue homeostasis and regenerative capacity (except for newts) in which somatic stem cells are thought to play an important...

    Authors: Karl JA McCullagh
    Citation: Stem Cell Research & Therapy 2012 3:19
  28. It is hypothesized that administration of stromal/stem cells isolated from the adipose tissue (ASCs) and umbilical cord (HUCPVCs) can ameliorate the injured central nervous system (CNS). It is still not clear,...

    Authors: Carlos A Ribeiro, Joana S Fraga, Mário Grãos, Nuno M Neves, Rui L Reis, Jeffrey M Gimble, Nuno Sousa and António J Salgado
    Citation: Stem Cell Research & Therapy 2012 3:18
  29. The clinical use of stem cells, such as bone marrow-derived and, more recently, resident cardiac stem cells, offers great promise for treatment of myocardial infarction and heart failure. The epicardium-derive...

    Authors: Nenad Bursac
    Citation: Stem Cell Research & Therapy 2012 3:15
  30. Stem cells have tremendous applications in the field of regenerative medicine and tissue engineering. These are pioneering fields that aim to create new treatments for disease that currently have limited thera...

    Authors: Ian Wimpenny, Hareklea Markides and Alicia J El Haj
    Citation: Stem Cell Research & Therapy 2012 3:13
  31. Down syndrome (DS), a major cause of mental retardation, is caused by trisomy of some or all of human chromosome 21 and includes three basic karyotypes: trisomy 21, translocation, and mosaicism. The derivation...

    Authors: Xiaoning Mou, Yuanbo Wu, Henghua Cao, Qingzhang Meng, Qihui Wang, Chengchao Sun, Shengshou Hu, Yue Ma and Hao Zhang
    Citation: Stem Cell Research & Therapy 2012 3:14
  32. The development of reproducible methods for deriving human embryonic stem cell (hESC) lines in compliance with good manufacturing practice (GMP) is essential for the development of hESC-based therapies. Althou...

    Authors: Nilendran Prathalingam, Linda Ferguson, Lesley Young, Georg Lietz, Rachel Oldershaw, Lyn Healy, Albert Craig, Helen Lister, Rakesh Binaykia, Radhika Sheth, Alison Murdoch and Mary Herbert
    Citation: Stem Cell Research & Therapy 2012 3:12
  33. Tissues characterized by constant turnover contain post-mitotic, terminally differentiated cells originating from highly proliferative progenitors, which in turn derive from a relatively small population of st...

    Authors: Roberta Sottocornola and Cristina Lo Celso
    Citation: Stem Cell Research & Therapy 2012 3:10
  34. Induced pluripotent stem (iPS) cells, obtained from reprogramming somatic cells by ectopic expression of a defined set of transcription factors or chemicals, are expected to be used as differentiated cells for...

    Authors: Tohru Sugawara, Koichiro Nishino, Akihiro Umezawa and Hidenori Akutsu
    Citation: Stem Cell Research & Therapy 2012 3:8
  35. The capacity of bone marrow mesenchymal stromal cells (BMSCs) to be induced into chondrocytes has drawn much attention for cell-based cartilage repair. BMSCs represent a small proportion of cells of the bone m...

    Authors: Adetola B Adesida, Aillette Mulet-Sierra and Nadr M Jomha
    Citation: Stem Cell Research & Therapy 2012 3:9
  36. Avascular necrosis (AVN) of the femoral head is a debilitating disease of multifactorial genesis, predominately affects young patients, and often leads to the development of secondary osteoarthritis. The evolv...

    Authors: Lars Rackwitz, Lars Eden, Stephan Reppenhagen, Johannes C Reichert, Franz Jakob, Heike Walles, Oliver Pullig, Rocky S Tuan, Maximilian Rudert and Ulrich Nöth
    Citation: Stem Cell Research & Therapy 2012 3:7
  37. Mesenchymal stem cells (MSCs) are multipotent cells able to differentiate into several mesenchymal lineages, classically derived from bone marrow (BM) but potentially from umbilical cord blood (UCB). Although ...

    Authors: Nesrine Ben Azouna, Faouzi Jenhani, Zohra Regaya, Lamia Berraeis, Tarek Ben Othman, Elfi Ducrocq and Jorge Domenech
    Citation: Stem Cell Research & Therapy 2012 3:6
  38. Glioma stem cells (GSCs) have the property of self-renewal and appear to be a driving force for the initiation and recurrence of gliomas. We recently found that the human tumorigenic LN-229 glioma cell line fa...

    Authors: Lei Wang, Ziyan Liu, Sivasai Balivada, Tej Shrestha, Stefan Bossmann, Marla Pyle, Loretta Pappan, Jishu Shi and Deryl Troyer
    Citation: Stem Cell Research & Therapy 2012 3:5
  39. Human induced pluripotent stem cells offer the possibility of generating unlimited quantities of cells for autologous transplantation. By correcting the genetic defect underlying Z-allele α1-antitrypsin deficienc...

    Authors: S Tamir Rashid and David A Lomas
    Citation: Stem Cell Research & Therapy 2012 3:4
  40. Stem cells are currently seen as a treatment for tissue regeneration in neurological diseases such as multiple sclerosis, anticipating that they integrate and differentiate into neural cells. Mesenchymal stem ...

    Authors: Sara Morando, Tiziana Vigo, Marianna Esposito, Simona Casazza, Giovanni Novi, Maria Cristina Principato, Roberto Furlan and Antonio Uccelli
    Citation: Stem Cell Research & Therapy 2012 3:3

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