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  1. Recent evidence suggests that accumulation of marrow adipose tissue induced by aberrant lineage allocation of bone marrow-derived mesenchymal stromal cells (BMSCs) contributes to the pathophysiologic processes...

    Authors: Shuang Zhang, Jeroen van de Peppel, Marijke Koedam, Johannes P. T. M. van Leeuwen and Bram C. J. van der Eerden
    Citation: Stem Cell Research & Therapy 2023 14:126
    Content type: Research Published on:

  3. Authors: Satoru Yabuno, Takao Yasuhara, Takayuki Nagase, Satoshi Kawauchi, Chiaki Sugahara, Yosuke Okazaki, Kakeru Hosomoto, Susumu Sasada, Tatsuya Sasaki, Naoki Tajiri, Cesar V. Borlongan and Isao Date
    Citation: Stem Cell Research & Therapy 2023 14:123
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2023 14:10

  4. Over the past few years, mesenchymal stromal cells (MSCs) have attracted a great deal of scientific attention owing to their promising results in the treatment of incurable diseases. However, there are several...

    Authors: Maryam Ghasemi, Elham Roshandel, Mozhdeh Mohammadian, Behrouz Farhadihosseinabadi, Parvin Akbarzadehlaleh and Karim Shamsasenjan
    Citation: Stem Cell Research & Therapy 2023 14:122
    Content type: Review Published on:

  5. Fibrosis is a common histological feature in the process from chronic organ injury to organ failure. Chronic tissue injury causes inflammatory cell infiltration into the injured tissue. The persistence of this...

    Authors: Naoki Ishiuchi, Ayumu Nakashima, Satoshi Maeda, Yoshie Miura, Kisho Miyasako, Kensuke Sasaki, Toshio Uchiki, Ayano Sasaki, Shogo Nagamatsu, Naoki Nakao, Masataka Nagao and Takao Masaki
    Citation: Stem Cell Research & Therapy 2023 14:121
    Content type: Research Published on:

  6. Mesenchymal stromal cells (MSCs), commonly sourced from adipose tissue, bone marrow and umbilical cord, have been widely used in many medical conditions due to their therapeutic potential. Yet, the still limit...

    Authors: Sandra Calcat-i-Cervera, Erika Rendra, Eleonora Scaccia, Francesco Amadeo, Vivien Hanson, Bettina Wilm, Patricia Murray, Timothy O’Brien, Arthur Taylor and Karen Bieback
    Citation: Stem Cell Research & Therapy 2023 14:120
    Content type: Research Published on:

  7. Cancer stem cells (CSCs) play an important role in endometrial cancer progression and it is potential to isolate CSCs from spheroid cells. Further understanding of spheroid cells at protein level would help fi...

    Authors: Mingzhu Cao, Zhi Liu, Danming You, Yingying Pan and Qingyan Zhang
    Citation: Stem Cell Research & Therapy 2023 14:119
    Content type: Research Published on:

  8. Elevated levels of inflammatory factors are associated with poor prognosis in coronavirus disease-19 (COVID-19). However, mesenchymal stem cells (MSCs) have immunomodulatory functions. Accordingly, this meta-a...

    Authors: Qinxue Liu, Fengjie Ma, Yizhi Zhong, Gaojian Wang, Li Hu, Yaping Zhang and Junran Xie
    Citation: Stem Cell Research & Therapy 2023 14:118
    Content type: Review Published on:

  9. The last decade has seen a significant increase in media attention, industrial growth, and patient interest in stem cell-based interventions. This led to a rise in direct-to-consumer businesses offering stem c...

    Authors: Atiyeh Asadpour, Badrul Hisham Yahaya, Katrina Bicknell, Graeme S. Cottrell and Darius Widera
    Citation: Stem Cell Research & Therapy 2023 14:111
    Content type: Research Published on:

  10. In vertebrates, hematopoietic stem and progenitor cells (HSPCs) emerge from hemogenic endothelium in the floor of the dorsal aorta and subsequently migrate to secondary niches where they expand and differentia...

    Authors: Honghu Li, Qian Luo, Shuyang Cai, Ruxiu Tie, Ye Meng, Wei Shan, Yulin Xu, Xiangjun Zeng, Pengxu Qian and He Huang
    Citation: Stem Cell Research & Therapy 2023 14:117
    Content type: Research Published on:

  11. Considering the high prevalence and the lack of targeted pharmacological management of acute kidney injury (AKI), the search for new therapeutic approaches for it is in urgent demand. Mesenchymal stem cells (M...

    Authors: Zhangning Fu, Yifan Zhang, Xiaodong Geng, Kun Chi, Chao Liu, Chengcheng Song, Guangyan Cai, Xiangmei Chen and Quan Hong
    Citation: Stem Cell Research & Therapy 2023 14:116
    Content type: Review Published on:

  12. To evaluate the safety and efficacy of autologous bone marrow mononuclear cell (BMMNC) infusion in the management of neurological sequelae in children with spina bifida (SB).

    Authors: Liem Thanh Nguyen, Huong Thu Le, Kien Trung Nguyen, Hang Thi Bui, Anh Phuong Thi Nguyen, Doan Van Ngo, Duc Minh Hoang and Minh Duy Ngo
    Citation: Stem Cell Research & Therapy 2023 14:115
    Content type: Research Published on:

  13. Millions of people have been affected ever since the emergence of the corona virus disease of 2019 (COVID-19) outbreak, leading to an urgent need for antiviral drug and vaccine development. Current experimenta...

    Authors: Toka A. Ahmed, Bassant Eldaly, Shadwa Eldosuky, Hoda Elkhenany, Azza M. El-Derby, Muhamed F. Elshazly and Nagwa El-Badri
    Citation: Stem Cell Research & Therapy 2023 14:114
    Content type: Review Published on:

  14. Intrauterine adhesion (IUA) is a reproductive dysfunction disease characterized by endometrial fibrosis, with limited therapeutic options and poor prognosis. Our previous studies confirmed that menstrual blood...

    Authors: Xudong Zhang, Siwen Zhang, Jiarui Qi, Fujie Zhao, Yimeng Lu, Shuyu Li, Shanshan Wu, Pingping Li and Jichun Tan
    Citation: Stem Cell Research & Therapy 2023 14:113
    Content type: Research Published on:

  15. Cell therapy is an accessible method for curing damaged organs or tissues. Yet, this approach is limited by the delivery efficiency of cell suspension injection. Over recent years, biological scaffolds have em...

    Authors: Danping Hu, Xinyu Li, Jie Li, Pei Tong, Zhe Li, Ge Lin, Yi Sun and Juan Wang
    Citation: Stem Cell Research & Therapy 2023 14:112
    Content type: Review Published on:

  16. CRISPR/Cas9 editing systems are currently used to generate mutations in a particular gene to mimic a genetic disorder in vitro. Such “disease in a dish” models based on human pluripotent stem cells (hPSCs) off...

    Authors: Elie Frank, Michel Cailleret, Constantin Nelep, Pascal Fragner, Jérome Polentes, Elise Herardot, Lina El Kassar, Karine Giraud-Triboult, Christelle Monville and Karim Ben M’Barek
    Citation: Stem Cell Research & Therapy 2023 14:110
    Content type: Method Published on:

  17. Regulating the pluripotency of human dental pulp stem cells (hDPSCs) is key for the self-repair of injured dental pulp. We previously found that OCT4A promotes the proliferation and odontogenic differentiation...

    Authors: Hong Hong, Kai Zeng, Can Zhou, Xiaochuan Chen, Zhezhen Xu, Mengjie Li, Lu Liu, Qian Zeng, Qian Tao and Xi Wei
    Citation: Stem Cell Research & Therapy 2023 14:109
    Content type: Research Published on:

  18. Duchenne muscular dystrophy (DMD) is an incurable genetic disease characterized by degeneration and necrosis of myofibers, chronic inflammation, and progressive muscle weakness resulting in premature mortality...

    Authors: Yuko Nitahara-Kasahara, Soya Nakayama, Koichi Kimura, Sho Yamaguchi, Yuko Kakiuchi, Chikako Nito, Masahiro Hayashi, Tomoyuki Nakaishi, Yasuyoshi Ueda and Takashi Okada
    Citation: Stem Cell Research & Therapy 2023 14:108
    Content type: Research Published on:

  19. Wound healing is a dynamic and highly sequential process involving a series of overlapping spatial and temporal phases, including hemostasis, inflammation, proliferation, and tissue remodeling. Mesenchymal ste...

    Authors: Chuchao Zhou, Boyu Zhang, Yanqing Yang, Qiong Jiang, Tianyu Li, Jun Gong, Hongbo Tang and Qi Zhang
    Citation: Stem Cell Research & Therapy 2023 14:107
    Content type: Review Published on:

  20. Blood transfusion is an essential part of medicine. However, many countries have been facing a national blood crisis. To address this ongoing blood shortage issue, there have been efforts to generate red blood...

    Authors: Youn Keong Cho, Hyun-Kyung Kim, Soon Sung Kwon, Su-Hee Jeon, June-Won Cheong, Ki Taek Nam, Han-Soo Kim, Sinyoung Kim and Hyun Ok Kim
    Citation: Stem Cell Research & Therapy 2023 14:106
    Content type: Research Published on:

  21. The maintenance of intestinal renewal and repair mainly depends on intestinal stem cells (ISCs), which can also contribute to the growth of intestinal tumours. Hormones, which are vital signalling agents in th...

    Authors: Li Liu, Lilong Zhang, Chunlei Li, Zhendong Qiu, Tianrui Kuang, Zhongkai Wu and Wenhong Deng
    Citation: Stem Cell Research & Therapy 2023 14:105
    Content type: Review Published on:

  22. Although mesenchymal stem cells (MSCs) have been effective in tendinopathy, the mechanisms by which MSCs promote tendon healing have not been fully elucidated. In this study, we tested the hypothesis that MSCs...

    Authors: Bing Wei, Mingliang Ji, Yucheng Lin, Shanzheng Wang, Yuxi Liu, Rui Geng, Xinyue Hu, Li Xu, Zhuang Li, Weituo Zhang and Jun Lu
    Citation: Stem Cell Research & Therapy 2023 14:104
    Content type: Research Published on:

  23. Perianal fistulas, characterised as granulomatous inflammation of fistulas around the anal canal, are associated with significant morbidity resulting in a negative impact on quality of life and a tremendous bu...

    Authors: H. Wang, H. Y. Jiang, Y. X. Zhang, H. Y. Jin, B. Y. Fei and J. L. Jiang
    Citation: Stem Cell Research & Therapy 2023 14:103
    Content type: Review Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2024 15:45

    The Commentary to this article has been published in Stem Cell Research & Therapy 2023 14:375

  24. Tissue engineering combines cell biology and material science to construct tissues or organs for disease modeling, drug testing, and regenerative medicine. The cell sheet is a newly developed tissue engineerin...

    Authors: Dehua Chang, Xiaotong Yang, Siyang Fan, Taibing Fan, Mingkui Zhang and Minoru Ono
    Citation: Stem Cell Research & Therapy 2023 14:102
    Content type: Review Published on:

  25. The efficiency of inducing human embryonic stem cells into NEUROG3+ pancreatic endocrine cells is a bottleneck in stem cell therapy for diabetes. To understand the cell properties and fate decisions during dif...

    Authors: Jin Li, Junru Chen, Xiaoyu Luo, Guangxiu Lu and Ge Lin
    Citation: Stem Cell Research & Therapy 2023 14:101
    Content type: Letter Published on:

  26. Adipose tissue-derived stem cell (ADSC) transplantation has been shown to be effective for the management of severe liver disorders. Preactivation of ADSCs enhanced their therapeutic efficacy. However, these e...

    Authors: Xiaoyu Luan, Peng Chen, Yaxin Li, Xinying Yuan, Longyu Miao, Pengyu Zhang, Qilong Cao, Xiaomin Song and Guohu Di
    Citation: Stem Cell Research & Therapy 2023 14:100
    Content type: Research Published on:

  27. Continuous cross talk between MSCs and macrophages is integral to acute and chronic inflammation resulting from contaminated polyethylene particles (cPE); however, the effect of this inflammatory microenvironm...

    Authors: Victoria Teissier, Qi Gao, Huaishuang Shen, Jiannan Li, Xueping Li, Elijah Ejun Huang, Junichi Kushioka, Masakazu Toya, Masanori Tsubosaka, Hirohito Hirata, Hossein Vahid Alizadeh, Chima V. Maduka, Christopher H. Contag, Yunzhi Peter Yang, Ning Zhang and Stuart B. Goodman
    Citation: Stem Cell Research & Therapy 2023 14:99
    Content type: Research Published on:

  28. G-quadruplex (G4) motifs are nucleic acid secondary structures observed in mammalian genomes and transcriptomes able to regulate various cellular processes. Several small molecules have been developed so far t...

    Authors: Maria Rosaria Ambrosio, Teresa Migliaccio, Fabiana Napolitano, Sarah Di Somma, Giovanni Maneli, Jussara Amato, Bruno Pagano, Antonio Randazzo, Giuseppe Portella, Pietro Formisano and Anna Maria Malfitano
    Citation: Stem Cell Research & Therapy 2023 14:98
    Content type: Research Published on:

  29. Endogenously released adenine and uracil nucleotides favour the osteogenic commitment of bone marrow-derived mesenchymal stromal cells (BM-MSCs) through the activation of ATP-sensitive P2X7 and UDP-sensitive P2Y6

    Authors: José Bernardo Noronha-Matos, Rui Pinto-Cardoso, Catarina Bessa-Andrês, Maria Teresa Magalhães-Cardoso, Fátima Ferreirinha, Maria Adelina Costa, José Marinhas, Rolando Freitas, Rui Lemos, Adélio Vilaça, António Oliveira, Julie Pelletier, Jean Sévigny and Paulo Correia-de-Sá
    Citation: Stem Cell Research & Therapy 2023 14:97
    Content type: Research Published on:

  30. Constructs currently used to repair or replace congenitally diseased pediatric heart valves lack a viable cell population capable of functional adaptation in situ, necessitating repeated surgical intervention....

    Authors: Shouka Parvin Nejad, Monica Lecce, Bahram Mirani, Nataly Machado Siqueira, Zahra Mirzaei, J. Paul Santerre, John E. Davies and Craig A. Simmons
    Citation: Stem Cell Research & Therapy 2023 14:96
    Content type: Research Published on:

  31. This study reports the incidence of chronic graft versus host disease (GvHD) in allogeneic hematopoietic stem cell transplant (alloHCT) recipients who received SARS-CoV2 vaccination. The overall rates of new a...

    Authors: Dat Ngo, Jason Chen, Jose Tinajero, Ahmed Aribi, Shukaib Arslan, Guido Marcucci, Ryotaro Nakamura, Monzr M. Al Malki, Stephen J. Forman, Sanjeet Dadwal and Haris Ali
    Citation: Stem Cell Research & Therapy 2023 14:95
    Content type: Letter Published on:

  32. High-throughput pharmaco-toxicological testing frequently relies on the use of established liver-derived cell lines, such as HepG2 cells. However, these cells often display limited hepatic phenotype and featur...

    Authors: Guillem Garcia-Llorens, Teresa Martínez-Sena, Eugenia Pareja, Laia Tolosa, José V. Castell and Roque Bort
    Citation: Stem Cell Research & Therapy 2023 14:94
    Content type: Research Published on:

  33. Mesenchymal stem cell (MSC) transplantation therapy is highly investigated for the regenerative repair of cartilage defects. Low-intensity pulsed ultrasound (LIPUS) has the potential to promote chondrogenic di...

    Authors: Yiming Chen, Huiyi Yang, Zhaojie Wang, Rongrong Zhu, Liming Cheng and Qian Cheng
    Citation: Stem Cell Research & Therapy 2023 14:93
    Content type: Research Published on:

  34. Although human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) are a promising cell resource for cardiovascular research, these cells exhibit an immature phenotype that hampers their potential ...

    Authors: Jingjun Zhou, Baiping Cui, Xiaochen Wang, Hongkun Wang, Junnan Zheng, Fengfeng Guo, Yaxun Sun, Hangping Fan, Jiaxi Shen, Jun Su, Jue Wang, Haige Zhao, Yiquan Tang, Tingyu Gong, Ning Sun and Ping Liang
    Citation: Stem Cell Research & Therapy 2023 14:92
    Content type: Research Published on:

  35. The success of stem cell therapy for knee osteoarthritis (KOA) in preclinical animal models has accelerated the pace of clinical translation. However, it remains uncertain whether the current scientific eviden...

    Authors: Zhizhong Shang, Pingping Wanyan, Baolin Zhang, Mingchuan Wang and Xin Wang
    Citation: Stem Cell Research & Therapy 2023 14:91
    Content type: Review Published on:

  36. Muscular diseases and injuries are challenging issues in human medicine, resulting in physical disability. The advent of tissue engineering approaches has paved the way for the restoration and regeneration of ...

    Authors: Atieh Rezaei Namjoo, Fateme Nazary Abrbekoh, Sepideh Saghati, Hassan Amini, Mohammad Ali Ebrahimi Saadatlou and Reza Rahbarghazi
    Citation: Stem Cell Research & Therapy 2023 14:90
    Content type: Review Published on:

  37. Mesenchymal stem cells (MSCs) have been proven to prevent and clear corneal scarring and limbal stem cell deficiency. However, using animal-derived serum in a culture medium raises the ethical and regulatory b...

    Authors: Abhishek Sahoo, Mukesh Damala, Jilu Jaffet, Deeksha Prasad, Sayan Basu and Vivek Singh
    Citation: Stem Cell Research & Therapy 2023 14:89
    Content type: Research Published on:

  38. Mesenchymal stem cell (MSC) transplantation is a promising therapeutic approach for noise-induced hearing loss (NIHL). As the indispensable role of apoptosis in MSC transplantation was raised, the benefits of ...

    Authors: Xiaotong Huang, Xiaoxing Kou, Ting Zhan, Guokun Wei, Feinan He, Xueli Mao and Haidi Yang
    Citation: Stem Cell Research & Therapy 2023 14:88
    Content type: Research Published on:

  39. The first human brain organoid protocol was presented in the beginning of the previous decade, and since then, the field witnessed the development of many new brain region-specific models, and subsequent proto...

    Authors: Lance A. Mulder, Josse A. Depla, Adithya Sridhar, Katja Wolthers, Dasja Pajkrt and Renata Vieira de Sá
    Citation: Stem Cell Research & Therapy 2023 14:87
    Content type: Research Published on:

  40. We performed the first autologous oral mucosa-derived epithelial cell sheet transplantation therapy in a patient with refractory postoperative anastomotic stricture in congenital esophageal atresia (CEA) and c...

    Authors: Akihiro Fujino, Yasushi Fuchimoto, Teizaburo Mori, Motohiro Kano, Yohei Yamada, Michinobu Ohno, Yoshiyuki Baba, Nobutaka Isogawa, Katsuhiro Arai, Takako Yoshioka, Makoto Abe, Nobuo Kanai, Ryo Takagi, Masanori Maeda and Akihiro Umezawa
    Citation: Stem Cell Research & Therapy 2023 14:86
    Content type: Research Published on:

  41. Neuroinflammation is closely related to the development of Parkinson's disease (PD). Because of the extensive sources, non-invasive and periodical collection method, human menstrual blood-derived endometrial s...

    Authors: Han Li, Jinghui Wei, Zhigang Zhang, Junyao Li, Yaokai Ma, Ping Zhang and Juntang Lin
    Citation: Stem Cell Research & Therapy 2023 14:85
    Content type: Research Published on:

  43. Stem cell replacement holds the potential for sensorineural hearing loss (SNHL) treatment. However, its translation into clinical practice requires strategies for improving stem cell survival following intraco...

    Authors: Luisa H. Andrade da Silva, Rachel A. Heuer, Christian B. Roque, Tammy L. McGuire, Tomonori Hosoya, Hironobu Kimura, Kouichi Tamura and Akihiro J. Matsuoka
    Citation: Stem Cell Research & Therapy 2023 14:83
    Content type: Short report Published on:

  44. Radiation-induced xerostomia and oral mucositis are serious complications of radiation therapy for head and neck cancers. Current treatment options have limited efficacy. Mesenchymal stem cell (MSC) therapy ha...

    Authors: Zirui Guan, Jiaxin Zhang, Nan Jiang, Mingyan Tian, Hongyong Wang and Bing Liang
    Citation: Stem Cell Research & Therapy 2023 14:82
    Content type: Review Published on:

  45. There is an urgent clinical need for targeted strategies aimed at the treatment of bone defects resulting from fractures, infections or tumors. 3D scaffolds represent an alternative to allogeneic MSC transplan...

    Authors: Svetlana Rodimova, Artem Mozherov, Vadim Elagin, Maria Karabut, Ilya Shchechkin, Dmitry Kozlov, Dmitry Krylov, Alena Gavrina, Vladislav Kaplin, Evgenii Epifanov, Nikita Minaev, Ksenia Bardakova, Anna Solovieva, Peter Timashev, Elena Zagaynova and Daria Kuznetsova
    Citation: Stem Cell Research & Therapy 2023 14:81
    Content type: Research Published on:

  46. Parkinson's disease (PD) is a neurodegenerative disease characterized by the degeneration of dopaminergic neurons in the substantia nigra (SN); the etiology and pathological mechanism of the disease are still ...

    Authors: Yi Zhuo, Xuan Li, Zhengwen He and Ming Lu
    Citation: Stem Cell Research & Therapy 2023 14:80
    Content type: Review Published on:

  47. Immune thrombocytopenia (ITP) is an acquired autoimmune disease involving a variety of immune cells and factors. Despite being a benign disease, it is still considered incurable due to its complex pathogenesis...

    Authors: Feifeng Wu, Zhou She, Cuifang Li, Jueyi Mao, Senlin Luo, Xiaoyu Chen, Jidong Tian and Chuan Wen
    Citation: Stem Cell Research & Therapy 2023 14:79
    Content type: Review Published on:

  48. Posterolateral spinal fusion is the standard surgical approach for patients with degenerative disc disease. In our previously published article, we reported a 5-years follow-up of a phase I/II clinical trial i...

    Authors: Victoria Gomez-Ruiz, Juan F. Blanco, Eva M. Villarón, Helena Fidalgo, Miriam López-Parra and Fermín Sánchez-Guijo
    Citation: Stem Cell Research & Therapy 2023 14:78
    Content type: Letter Published on:

  49. Human dental pulp-derived mesenchymal stem cells (hDP-MSCs), which include human dental pulp stem cells (hDPSCs) and stem cells from human exfoliated deciduous teeth (SHEDs), are promising cell sources for reg...

    Authors: Pedram Iranmanesh, Amirhossein Vedaei, Sadra Salehi-Mazandarani, Parvaneh Nikpour, Saber Khazaei, Abbasali Khademi, Kerstin M. Galler, Mohammad-Hossein Nekoofar and Paul M. H. Dummer
    Citation: Stem Cell Research & Therapy 2023 14:76
    Content type: Research Published on:

  50. The increasing incidence of osteoporosis in recent years has aroused widespread public concern; however, existing effective treatments are limited. Therefore, new osteoporosis treatment methods, including stem...

    Authors: Xiaoyu He, Yangbin Wang, Zhihua Liu, Yiyong Weng, Shupeng Chen, Qunlong Pan, Yizhong Li, Hanshi Wang, Shu Lin and Haiming Yu
    Citation: Stem Cell Research & Therapy 2023 14:72
    Content type: Review Published on:
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