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  1. Allogeneic hematopoietic stem cell transplantation (AHSCT) is a curative therapeutic approach for different hematological malignancies (HMs), and epigenetic modifications, including DNA methylation, play a rol...

    Authors: Stefania Trino, Pietro Zoppoli, Angelo Michele Carella, Ilaria Laurenzana, Alessandro Weisz, Domenico Memoli, Giovanni Calice, Francesco La Rocca, Vittorio Simeon, Lucia Savino, Luigi Del Vecchio, Pellegrino Musto, Antonella Caivano and Luciana De Luca
    Citation: Stem Cell Research & Therapy 2019 10:138
    Content type: Research Published on:

  3. Human pluripotent stem cells (hPSCs) provide supplies of potential functional blood cells to suffice the clinical needs. However, the underlying mechanism of generating genuine hematopoietic stem cells (HSCs) ...

    Authors: Yv Wang, Jie Gao, Hongtao Wang, Mengge Wang, Yuqi Wen, Jiaojiao Guo, Pei Su, Lihong Shi, Wen Zhou and Jiaxi Zhou
    Citation: Stem Cell Research & Therapy 2019 10:136
    Content type: Research Published on:

  4. Xenotransplantation of spermatogonial stem cells (SSCs) has become a popular topic in various research fields because manipulating these cells can provide insights into the mechanisms associated with germ cell...

    Authors: Naira Caroline Godoy Pieri, Ana Carolina Furlanetto Mançanares, Aline Fernanda de Souza, Hugo Fernandes, Angela Maria Gonella Diaza, Fabiana Fernandes Bressan, Kelly Cristine Santos Roballo, Juliana Barbosa Casals, Mario Binelli, Carlos Eduardo Ambrósio and Daniele dos Santos Martins
    Citation: Stem Cell Research & Therapy 2019 10:135
    Content type: Research Published on:

  5. Concentrated growth factor (CGF), as a natural biomaterial, is known to contain platelets, cytokines, and growth factors to facilitate the healing process, but there has been little information acquired in reg...

    Authors: Fangfang Xu, Lu Qiao, Yumei Zhao, Weiting Chen, Shebing Hong, Jing Pan and Beizhan Jiang
    Citation: Stem Cell Research & Therapy 2019 10:134
    Content type: Research Published on:

  6. Delivery of endothelial cells into the ischemic tissue is emerging as an alternative approach in revascularization of injured tissues by means of angiogenesis to restore organ function. Adipose-derived stem ce...

    Authors: Ting Shang, Shuaijun Li, Yun Zhang, Laiya Lu, Lei Cui and Fang Fang Guo
    Citation: Stem Cell Research & Therapy 2019 10:133
    Content type: Research Published on:

  7. The original article [1] contained an error in the presentation of the first author’s name, Nádia de Cássia Noronha. This has now been corrected.

    Authors: Nádia de Cássia Noronha, Amanda Mizukami, Carolina Caliári-Oliveira, Juçara Gastaldi Cominal, José Lucas M. Rocha, Dimas Tadeu Covas, Kamilla Swiech and Kelen C. R. Malmegrim
    Citation: Stem Cell Research & Therapy 2019 10:132
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2019 10:131

  8. Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based therapy of immune-mediated, inflammatory, and degenerative diseases, due to their immunosuppressive, immunomodulatory, and r...

    Authors: Nádia de Cássia Noronha, Amanda Mizukami, Carolina Caliári-Oliveira, Juçara Gastaldi Cominal, José Lucas M. Rocha, Dimas Tadeu Covas, Kamilla Swiech and Kelen C. R. Malmegrim
    Citation: Stem Cell Research & Therapy 2019 10:131
    Content type: Review Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:132

  9. Pluripotent stem cells are attractive progenitor cells for the generation of erythroid cells in vitro as have expansive proliferative potential. However, although embryonic (ESC) and induced pluripotent (iPSC)...

    Authors: Kongtana Trakarnsanga, Daniel Ferguson, Deborah E. Daniels, Rebecca E. Griffiths, Marieangela C. Wilson, Kathryn E. Mordue, Abi Gartner, Tatyana N. Andrienko, Annabel Calvert, Alison Condie, Angela McCahill, Joanne C. Mountford, Ashley M. Toye, David J. Anstee and Jan Frayne
    Citation: Stem Cell Research & Therapy 2019 10:130
    Content type: Research Published on:

  10. Poor cell engraftment and survival after transplantation limited the application of stem cell therapy. Synthetic biomaterials could provide an artificial microenvironment for stem cells, thereby improve cell s...

    Authors: Nianhuan Zhao, Zhiwei Yue, Jian Cui, Yong Yao, Xianghe Song, Bangping Cui, Xin Qi, Zhibo Han, Zhong-Chao Han, Zhikun Guo, Zuo-Xiang He and Zongjin Li
    Citation: Stem Cell Research & Therapy 2019 10:129
    Content type: Research Published on:

  11. Odontoblast is a unique progenitor that plays a role in dentin formation. So far, the dentinogenic differentiation of dental pulp stem cells and the role of surface molecules of odontoblasts in dentinogenesis ...

    Authors: Kyung-Jung Kang, Chun-Jeih Ryu and Young-Joo Jang
    Citation: Stem Cell Research & Therapy 2019 10:128
    Content type: Research Published on:

  12. Bone-derived mesenchymal stem cell (BMSC) transplantation has been reported to be effective for the treatment of ischemic heart disease, but whether BMSCs are the optimal cell type remains under debate. Increa...

    Authors: Dihan Lu, Yan Liao, Shuang-Hua Zhu, Qiao-Chao Chen, Dong-Mei Xie, Jian-Jun Liao, Xia Feng, Mei Hua Jiang and Wen He
    Citation: Stem Cell Research & Therapy 2019 10:127
    Content type: Research Published on:

  13. The treatment of extensive and/or chronic skin wounds is a widespread and costly public health problem. Mesenchymal stem cells (MSCs) have been proposed as a potential cell therapy for inducing wound healing i...

    Authors: José E. Millán-Rivero, Carlos M. Martínez, Paola A. Romecín, Salvador D. Aznar-Cervantes, Marina Carpes-Ruiz, José L. Cenis, Jose M. Moraleda, Noemí M. Atucha and David García-Bernal
    Citation: Stem Cell Research & Therapy 2019 10:126
    Content type: Research Published on:

  14. Stem cell transplantation (SCT) has become a promising way to treat ischemic heart failure (IHF). We performed a large-scale meta-analysis of randomized clinical trials to investigate the efficacy and safety o...

    Authors: Yixuan Wang, Fen Xu, Jingwei Ma, Jiawei Shi, Si Chen, Zongtao Liu and Junwei Liu
    Citation: Stem Cell Research & Therapy 2019 10:125
    Content type: Review Published on:

  15. Emerging evidence shows that epithelial-mesenchymal transition (EMT) plays a crucial role in tumor invasion, metastasis, cancer stem cells, and drug resistance. Data obtained thus far have revealed that F-box ...

    Authors: Yizuo Song, Min Lin, Yi Liu, Zhi-Wei Wang and Xueqiong Zhu
    Citation: Stem Cell Research & Therapy 2019 10:124
    Content type: Review Published on:

  16. IL-33 is a pleiotropic cytokine of the IL-1 family, which has been reported to implicate in both innate and adaptive immune responses. Recent studies suggest IL-33 is crucial for regulation of myelopoiesis and...

    Authors: Ping Huang, Xiangyong Li, Ying Meng, Baohong Yuan, Tao Liu, Mengya Jiao, Xiaodi Wang, Yunjun Liu and Hui Yin
    Citation: Stem Cell Research & Therapy 2019 10:123
    Content type: Research Published on:

  17. Sox2 is a well-established pluripotent transcription factor that plays an essential role in establishing and maintaining pluripotent stem cells (PSCs). It is also thought to be a linage specifier that governs ...

    Authors: Shuchen Zhang, Emma Bell, Huihan Zhi, Sarah Brown, Siti A. M. Imran, Véronique Azuara and Wei Cui
    Citation: Stem Cell Research & Therapy 2019 10:122
    Content type: Research Published on:

  18. Retina and/or optic nerve injury may cause irreversible blindness, due to degeneration of retinal ganglion cells. We and others have previously shown that the intravitreal injection of mesenchymal stem cells (...

    Authors: Louise A. Mesentier-Louro, Leandro C. Teixeira-Pinheiro, Fernanda Gubert, Juliana F. Vasques, Almir J. Silva-Junior, Luiza Chimeli-Ormonde, Gabriel Nascimento-dos-Santos, Rosalia Mendez-Otero and Marcelo F. Santiago
    Citation: Stem Cell Research & Therapy 2019 10:121
    Content type: Research Published on:

  19. In mammals, a basal level of autophagy, a self-eating cellular process, degrades cytosolic proteins and subcellular organelles in lysosomes to provide energy, recycles the cytoplasmic components, and regenerat...

    Authors: Chenxia Hu, Lingfei Zhao, Daxian Wu and Lanjuan Li
    Citation: Stem Cell Research & Therapy 2019 10:120
    Content type: Review Published on:

  20. Stem cell-based therapy appears to be a promising new candidate for acute kidney injury (AKI) management. Traditionally, it has been accepted that the mechanism underlying the regenerative effect of stem cells...

    Authors: Lingfei Zhao, Chenxia Hu, Ping Zhang, Hua Jiang and Jianghua Chen
    Citation: Stem Cell Research & Therapy 2019 10:119
    Content type: Review Published on:

  21. Adult stem cells exist in a quiescent state (G0) within the in vivo niche; the loss of quiescence often leads to a decrease in the number and function of adult stem cells, impairing tissue regeneration and rep...

    Authors: Bin Li, Chao Sun, Jing Sun, Ming-hui Yang, Rui Zuo, Chang Liu, Wei-ren Lan, Ming-han Liu, Bo Huang and Yue Zhou
    Citation: Stem Cell Research & Therapy 2019 10:118
    Content type: Research Published on:

  22. Although adipocytes are the most abundant stromal cell component in breast cancer tissues, their interaction with breast cancer cells has been less investigated compared to cancer-associated fibroblasts or mac...

    Authors: Shihua Wang, Xiaodong Su, Meiqian Xu, Xian Xiao, Xiaoxia Li, Hongling Li, Armand Keating and Robert Chunhua Zhao
    Citation: Stem Cell Research & Therapy 2019 10:117
    Content type: Research Published on:

  23. The mechanisms underpinning the regenerative capabilities of mesenchymal stem cells (MSC) were originally thought to reside in their ability to recognise damaged tissue and to differentiate into specific cell ...

    Authors: Robert Mitchell, Ben Mellows, Jonathan Sheard, Manuela Antonioli, Oliver Kretz, David Chambers, Marie-Theres Zeuner, James E. Tomkins, Bernd Denecke, Luca Musante, Barbara Joch, Florence Debacq-Chainiaux, Harry Holthofer, Steve Ray, Tobias B. Huber, Joern Dengjel…
    Citation: Stem Cell Research & Therapy 2019 10:116
    Content type: Research Published on:

  24. Mesenchymal stem cells (MSCs) and their cellular response to various stimuli have been characterized in great detail in culture conditions. In contrast, the cellular response of MSCs in an in vivo setting is s...

    Authors: Ramil Hakim, Ruxandra Covacu, Vasilios Zachariadis, Arvid Frostell, Sreenivasa Raghavan Sankavaram, Lou Brundin and Mikael Svensson
    Citation: Stem Cell Research & Therapy 2019 10:115
    Content type: Research Published on:

  25. Recent studies have shown that deficiency in the Fanconi anemia (FA) DNA repair pathway enhances the error-prone non-homologous end-joining (NHEJ) repair, leading to increased genomic instability, and that gen...

    Authors: Yan Nie, Yibo Li, Xiaoli Li, Andrew F. Wilson and Qishen Pang
    Citation: Stem Cell Research & Therapy 2019 10:114
    Content type: Research Published on:

  26. Pluripotent stem cell-derived cardiomyocytes (PSC-CMs) are widely used models for regenerative medicine and disease research. However, PSC-CMs are usually immature in morphology and functionality and the matur...

    Authors: Rou Chen, Jun He, Yumei Wang, You Guo, Juan Zhang, Luying Peng, Duo Wang, Qin Lin, Jie Zhang, Zheng Guo and Li Li
    Citation: Stem Cell Research & Therapy 2019 10:113
    Content type: Research Published on:

  27. New insights on cellular and molecular aspects of both oligodendrocyte (OL) differentiation and myelin synthesis pathways are potential avenues for developing a cell-based therapy for demyelinating disorders c...

    Authors: Negin Afrang, Rezvan Tavakoli, Nooshin Tasharrofi, Amir Alian, Alireza Naderi Sohi, Mahboubeh Kabiri, Mehrnoosh Fathi-Roudsari, Mina Soufizomorrod, Farzad Rajaei, Masoud Soleimani and Fatemeh Kouhkan
    Citation: Stem Cell Research & Therapy 2019 10:112
    Content type: Research Published on:

  28. Normal wound healing is a dynamic and complex multiple phase process involving coordinated interactions between growth factors, cytokines, chemokines, and various cells. Any failure in these phases may lead wo...

    Authors: Azar Nourian Dehkordi, Fatemeh Mirahmadi Babaheydari, Mohammad Chehelgerdi and Shiva Raeisi Dehkordi
    Citation: Stem Cell Research & Therapy 2019 10:111
    Content type: Review Published on:

  29. Synthetic implants are being used to restore injured or damaged tissues following cancer resection and congenital diseases. However, the survival of large tissue implant replacements depends on their ability t...

    Authors: M. F. Griffin, N. Naderi, D. M. Kalaskar, A. M. Seifalian and P. E. Butler
    Citation: Stem Cell Research & Therapy 2019 10:110
    Content type: Research Published on:

  30. Osteoarthritis (OA) is the most prevalent joint disease, and to date, no options for effective tissue repair and restoration are available. With the aim of developing new therapies, the impact of mesenchymal s...

    Authors: Enrico Ragni, Carlotta Perucca Orfei, Paola De Luca, Gaia Lugano, Marco Viganò, Alessandra Colombini, Federico Valli, Daniele Zacchetti, Valentina Bollati and Laura de Girolamo
    Citation: Stem Cell Research & Therapy 2019 10:109
    Content type: Research Published on:

  31. Tendons are a crucial component of the musculoskeletal system and responsible for transmission forces derived from muscle to bone. Patients with tendon injuries are often observed with decreased collagen produ...

    Authors: Yang Liu, Lu Feng, Jia Xu, Zhengmeng Yang, Tianyi Wu, Jiajun Zhang, Liu Shi, Dahai Zhu, Jinfang Zhang and Gang Li
    Citation: Stem Cell Research & Therapy 2019 10:108
    Content type: Research Published on:

  32. Intrauterine adhesion (IUA) is characterized by progressive intrauterine fibrosis as a consequence of trauma to the basal layer of the endometrium. In an attempt to relieve IUA, many approaches have been appli...

    Authors: Xing Chen, Jingtao Sun, Xiaoyu Li, Lele Mao, Lei Cui and Wenpei Bai
    Citation: Stem Cell Research & Therapy 2019 10:107
    Content type: Research Published on:

  33. Human adipose-derived stem cells (hADSCs) are an important source of cells for regenerative medicine. Evidence of extensive interactions with the surrounding microenvironment has led researchers to focus more ...

    Authors: Fen Xu, Qinqin Xiang, Jiuzuo Huang, Qianlong Chen, Nanze Yu, Xiao Long and Zhou Zhou
    Citation: Stem Cell Research & Therapy 2019 10:106
    Content type: Research Published on:

  34. Preterm newborns are at high risk of developing neurodevelopmental deficits caused by neuroinflammation leading to perinatal brain injury. Human Wharton’s jelly mesenchymal stem cells (hWJ-MSC) derived from th...

    Authors: Gierin Thomi, Daniel Surbek, Valérie Haesler, Marianne Joerger-Messerli and Andreina Schoeberlein
    Citation: Stem Cell Research & Therapy 2019 10:105
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2022 13:364

  35. Putative endothelial progenitor cells (pEPCs) have been confirmed to participate in alleviation of renal fibrosis in several ischaemic diseases. However, their mechanistic effect on renal fibrosis, which is ch...

    Authors: Juan Yang, Meng Wang, Fengming Zhu, Jie Sun, Huzi Xu, Octavia Li-Sien Chong Lee Shin, Zhi Zhao, Guangchang Pei, Han Zhu, Chujin Cao, Xiaofeng He, Yi Huang, Zufu Ma, Liu Liu, Le Wang, Yong Ning…
    Citation: Stem Cell Research & Therapy 2019 10:104
    Content type: Research Published on:

  37. Premature ovarian insufficiency is a common complication of anticancer treatments in young women and girls. The ovary is a complex, highly regulated reproductive organ, whose proper function is contingent upon...

    Authors: Lisa J. Green, Hong Zhou, Vasantha Padmanabhan and Ariella Shikanov
    Citation: Stem Cell Research & Therapy 2019 10:102
    Content type: Research Published on:

  38. The ex vivo expansion potential of mesenchymal stromal/stem cells (MSC) together with their differentiation and secretion properties makes these cells an attractive tool for transplantation and tissue engineer...

    Authors: Elisabetta Manuela Foppiani, Olivia Candini, Ilenia Mastrolia, Alba Murgia, Giulia Grisendi, Anna Valeria Samarelli, Giulia Boscaini, Lucrezia Pacchioni, Massimo Pinelli, Giorgio De Santis, Edwin M. Horwitz, Elena Veronesi and Massimo Dominici
    Citation: Stem Cell Research & Therapy 2019 10:101
    Content type: Research Published on:

  39. Primary mesenchymal stem cells (MSCs) are fraught with aging-related shortfalls. Human-induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) have been shown to be a useful clinically relevant source of MSC...

    Authors: Lucas-Sebastian Spitzhorn, Matthias Megges, Wasco Wruck, Md Shaifur Rahman, Jörg Otte, Özer Degistirici, Roland Meisel, Rüdiger Volker Sorg, Richard O. C. Oreffo and James Adjaye
    Citation: Stem Cell Research & Therapy 2019 10:100
    Content type: Research Published on:

  40. The manufacture of mesenchymal stem/stromal cells (MSCs) for clinical use needs to be cost effective, safe and scaled up. Current methods of expansion on tissue culture plastic are labour-intensive and involve...

    Authors: Claire Mennan, John Garcia, Sally Roberts, Charlotte Hulme and Karina Wright
    Citation: Stem Cell Research & Therapy 2019 10:99
    Content type: Research Published on:

  41. Mesenchymal stem cells (MSCs) are increasingly being applied as a therapy for liver fibrosis. Exosomes possess similar functions to their parent cells; however, they are safe and effective cell-free reagents w...

    Authors: Xiaoli Rong, Junzhi Liu, Xia Yao, Tiechao Jiang, Yimin Wang and Feng Xie
    Citation: Stem Cell Research & Therapy 2019 10:98
    Content type: Research Published on:

  42. The original article [1] was submitted and published without co-author Hong Chen’s permission.

    Authors: Xuejiao Sun, Jianyuan Song, Hailong Huang, Hong Chen and Kun Qian
    Citation: Stem Cell Research & Therapy 2019 10:97
    Content type: Correction Published on:

    The original article was published in Stem Cell Research & Therapy 2018 9:315

  43. Studies have shown that transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) protects against brain damage. However, the low survival number of transplanted BMSCs remains a pertinent challenge...

    Authors: Jiangnan Hu, Lefu Chen, Xujun Huang, Ke Wu, Saidan Ding, Weikan Wang, Brian Wang, Charity Smith, Changhong Ren, Haoqi Ni, Qichuan ZhuGe and Jianjing Yang
    Citation: Stem Cell Research & Therapy 2019 10:96
    Content type: Research Published on:

  44. It is confirmed that adipose-derived stem cells (ADSCs) transplantation effectively relieves kidney fibrosis and type 2 diabetes disease in mice. Currently, exosome from urine-derived stem cells (USCs) can pro...

    Authors: Juan Jin, Yifen Shi, Jianguang Gong, Li Zhao, Yiwen Li, Qiang He and He Huang
    Citation: Stem Cell Research & Therapy 2019 10:95
    Content type: Research Published on:

  45. The skin is the largest organ of the body, which meets the environment most directly. Thus, the skin is vulnerable to various damages, particularly burn injury. Skin wound healing is a serious interaction betw...

    Authors: Anastasia Shpichka, Denis Butnaru, Evgeny A. Bezrukov, Roman B. Sukhanov, Anthony Atala, Vitaliy Burdukovskii, Yuanyuan Zhang and Peter Timashev
    Citation: Stem Cell Research & Therapy 2019 10:94
    Content type: Review Published on:

  46. Adipose-derived mesenchymal stromal cells (ADSCs) are multipotent stromal cells. The cells secrete a number of cytokines and growth factors and show immunoregulatory and proangiogenic properties. Their propert...

    Authors: Ewelina Pilny, Ryszard Smolarczyk, Magdalena Jarosz-Biej, Alina Hadyk, Agnieszka Skorupa, Mateusz Ciszek, Łukasz Krakowczyk, Natalia Kułach, Danuta Gillner, Maria Sokół, Stanisław Szala and Tomasz Cichoń
    Citation: Stem Cell Research & Therapy 2019 10:93
    Content type: Research Published on:

  47. Vascular injury is one of the most common detrimental effects of cancer radiotherapy on healthy tissues. Since the efficacy of current preventive and therapeutic strategies remains limited, the exploration of ...

    Authors: Xuan Tao, Mingyang Sun, Min Chen, Rongchao Ying, Wenjie Su, Jian Zhang, Xiaodong Xie, Wei Wei and Xiaohu Meng
    Citation: Stem Cell Research & Therapy 2019 10:92
    Content type: Research Published on:

  48. Adipose-derived mesenchymal stem cells (ADMSCs) are considered an efficient and important candidate for male infertility treatment because they contain pluripotent stem cells, which can differentiate into all ...

    Authors: Yanxia Luo, Lili Xie, Ali Mohsin, Waqas Ahmed, Chenze Xu, Yan Peng, Haifeng Hang, Yingping Zhuang, Ju Chu and Meijin Guo
    Citation: Stem Cell Research & Therapy 2019 10:91
    Content type: Research Published on:

  49. Sulfur mustard (SM) is a notorious chemical warfare agent that can cause severe acute lung injury (ALI), in addition to other lesions. Currently, effective medical countermeasures for SM are lacking. Bone marr...

    Authors: Yongwei Feng, Qingqiang Xu, Yuyan Yang, Wenwen Shi, Wenqi Meng, Hao Zhang, Xiaowen He, Mingxue Sun, Yongchun Chen, Jie Zhao, Zhenhong Guo and Kai Xiao
    Citation: Stem Cell Research & Therapy 2019 10:90
    Content type: Research Published on:

  50. Human mesenchymal stem cell (MSC)-based tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene delivery is regarded as an effective treatment for glioblastoma (GBM). However, adverse-free target ...

    Authors: Man Li, Shoujia Sun, Sean Dangelmajer, Quan Zhang, Junwen Wang, Feng Hu, Fangyong Dong, Ulf D. Kahlert, Mingxin Zhu and Ting Lei
    Citation: Stem Cell Research & Therapy 2019 10:88
    Content type: Research Published on:
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