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  1. Mesenchymal stromal cells (MSCs) play an important role in the prevention of cell and tissue fibrosis. Senescence may decrease the function of MSCs during recovery from tissue and organ damage. Extracellular v...

    Authors: Yan Wang, Yi Fang Guo, Guang Ping Fu, Chang Guan, Xin Zhang, Dong Gang Yang and Yun Cong Shi

    Citation: Stem Cell Research & Therapy 2020 11:274

    Content type: Research

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  2. Age and other cardiovascular risk factors have been reported to impair the activities of mesenchymal stem cells (MSCs), which will affect the efficacy of stem cell transplantation. The objective of the study i...

    Authors: Ning Zhang, Jinyun Zhu, Qunchao Ma, Yun Zhao, Yingchao Wang, Xinyang Hu, Jinghai Chen, Wei Zhu, Zhongchao Han and Hong Yu

    Citation: Stem Cell Research & Therapy 2020 11:273

    Content type: Research

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  3. Adult clinical trials have reported safety and the therapeutic potential of stem cells for cardiac disease. These observations have now translated to the pediatric arena. We conducted a meta-analysis to assess...

    Authors: John Martinez, Sarah Zoretic, Axel Moreira and Alvaro Moreira

    Citation: Stem Cell Research & Therapy 2020 11:272

    Content type: Review

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  4. Mesenchymal stem cell (MSC)-based cartilage tissue regeneration is a treatment with great potential. How to enhance the MSC chondrogenic differentiation is a key issue involved in cartilage formation. In the p...

    Authors: Haoqing Yang, Yangyang Cao, Jianpeng Zhang, Yuncun Liang, Xiaomin Su, Chen Zhang, Huina Liu, Xiao Han, Lihua Ge and Zhipeng Fan

    Citation: Stem Cell Research & Therapy 2020 11:271

    Content type: Research

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  5. Prenatal dexamethasone exposure (PDE) induces low birth weight and retardation of fetal bone development which are associated with lower peak bone mass in adult offspring. Here we evaluated whether and how PDE...

    Authors: Jianwen Su, Yu Chai, Zhiguo Ji, Yongheng Xie, Bin Yu and Xianrong Zhang

    Citation: Stem Cell Research & Therapy 2020 11:270

    Content type: Research

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  6. Bone mass loss in aging is linked with imbalanced lineage differentiation of bone marrow mesenchymal stem cells (BMMSCs). Recent studies have proved that histone deacetylases (HDACs) are regarded as key regula...

    Authors: Liqiang Zhang, Meng Qi, Ji Chen, Jiangdong Zhao, Liya Li, Jiachen Hu, Yan Jin and Wenjia Liu

    Citation: Stem Cell Research & Therapy 2020 11:269

    Content type: Research

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  7. Previous studies of primary ovarian insufficiency (POI) have focused on granulosa cells (GCs) and ignored the role of theca-interstitial cells (TICs). This study aims to explore the mechanism of the protective...

    Authors: Xueyan Lu, Hongchu Bao, Linlu Cui, Wenqian Zhu, Lianshuang Zhang, Zheng Xu, Xuejing Man, Yongli Chu, Qiang Fu and Hongqin Zhang

    Citation: Stem Cell Research & Therapy 2020 11:268

    Content type: Research

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  8. Mesenchymal stem cells (MSCs) can provide therapeutic benefits for myocardial infarction (MI) recovery; however, the molecular mechanism by which MSCs improve the heart function is unclear.

    Authors: Baoping Deng, Xianlan Zhang, Yi Liang, Haiming Jiang, Weizhao Huang, Yinmeng Wu and Weiping Deng

    Citation: Stem Cell Research & Therapy 2020 11:266

    Content type: Research

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  9. Hemophagocytic lymphohistiocytosis (HLH) is a severe or even fatal inflammatory state. Epstein–Barr virus (EBV) infection-associated HLH (EBV-HLH) is one of the most common secondary HLH and suffers a very poo...

    Authors: Yue Song, Jingshi Wang, Yini Wang and Zhao Wang

    Citation: Stem Cell Research & Therapy 2020 11:265

    Content type: Research

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  10. Large numbers of adipose-derived stem cells (ADSCs) are easily obtained and have been demonstrated to protect against ultraviolet B (UVB)-induced skin photoaging. Extracellular vesicles (EVs) exhibit some of t...

    Authors: Peng Xu, Yu Xin, Zheng Zhang, Xiangyu Zou, Ke Xue, Huizhong Zhang, Wenjie Zhang and Kai Liu

    Citation: Stem Cell Research & Therapy 2020 11:264

    Content type: Research

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  11. Lamina-associated polypeptide 2α (LAP2α) is a nucleoplasmic protein that has been involved in the regulation of the cell cycle, gene transcription, and adult stem cell function. LAP2α down-regulation is linked...

    Authors: Yiman Tang, Xiao Zhang, Wenshu Ge and Yongsheng Zhou

    Citation: Stem Cell Research & Therapy 2020 11:263

    Content type: Research

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  12. Mesenchymal stem/stromal cells (MSC) are commonly used in regenerative medicine. Among different tissues, iliac crest bone marrow (BM) represents the most exploited source, but its disadvantages are a painful ...

    Authors: Katarzyna Drela, Luiza Stanaszek, Konrad Snioch, Zuzanna Kuczynska, Mikolaj Wrobel, Sylwia Sarzynska, Pawel Legosz, Pawel Maldyk and Barbara Lukomska

    Citation: Stem Cell Research & Therapy 2020 11:262

    Content type: Research

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  13. Wound healing is a complex biological process comprised of a series of sequential events aiming to repair injured tissue. Adult mesenchymal stem cells (MSCs) have been used in cellular therapy in preclinical a...

    Authors: Nathaly Enciso, Luis Avedillo, María Luisa Fermín, Cristina Fragío and Concepción Tejero

    Citation: Stem Cell Research & Therapy 2020 11:261

    Content type: Research

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  14. Mesenchymal stromal cell-derived exosomes (MSC-EXs) could exert protective effects on recipient cells by transferring the contained microRNAs (miRs), and miR-132-3p is one of angiogenic miRs. However, whether ...

    Authors: Qunwen Pan, Xiaoli Kuang, Shuyun Cai, Xiang Wang, Donghui Du, Jinju Wang, Yan Wang, Yanyu Chen, Ji Bihl, Yanfang Chen, Bin Zhao and Xiaotang Ma

    Citation: Stem Cell Research & Therapy 2020 11:260

    Content type: Research

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  15. After surgery, wound recovery in diabetic patients may be disrupted due to delayed inflammation, which can lead to undesired consequences, and there is currently a lack of effective measures to address this is...

    Authors: Wei Liu, Muyu Yu, Dong Xie, Longqing Wang, Cheng Ye, Qi Zhu, Fang Liu and Lili Yang

    Citation: Stem Cell Research & Therapy 2020 11:259

    Content type: Research

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  16. Prostate cancer stem-like cells (PCSCs) likely participate in tumor progression and recurrence and demonstrate resistance to chemotherapy. The Notch pathway plays a role in the maintenance of the stemness in P...

    Authors: Lei Wang, Hao Zi, Yi Luo, Tongzu Liu, Hang Zheng, Conghua Xie, Xinghuan Wang and Xing Huang

    Citation: Stem Cell Research & Therapy 2020 11:258

    Content type: Research

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  17. Schwann cells (SCs) are primarily responsible for regeneration and repair of the peripheral nervous system (PNS). Renewable and lineage-restricted SC precursors (SCPs) are considered highly desirable and promi...

    Authors: Han-Seop Kim, Jae Yun Kim, Cho Lok Song, Ji Eun Jeong and Yee Sook Cho

    Citation: Stem Cell Research & Therapy 2020 11:257

    Content type: Research

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  18. MSCTRAIL is a cell-based therapy consisting of human allogeneic umbilical cord-derived MSCs genetically modified to express the anti-cancer protein TRAIL. Though cell-based therapies are typically designed wit...

    Authors: P. Stephen Patrick, Krishna K. Kolluri, May Zaw Thin, Adam Edwards, Elizabeth K. Sage, Tom Sanderson, Benjamin D. Weil, John C. Dickson, Mark F. Lythgoe, Mark Lowdell, Sam M. Janes and Tammy L. Kalber

    Citation: Stem Cell Research & Therapy 2020 11:256

    Content type: Research

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  19. Clinical use of mesenchymal stem cells (MSCs) requires a uniform cell population, and their harvesting is invasive and produces a limited number of cells. Human embryonic stem cell-derived MSCs (hESC-MSCs) can...

    Authors: Sook Young Yoon, Jung Ah Yoon, Mira Park, Eun-Young Shin, Sookyung Jung, Jeoung Eun Lee, Jin Hee Eum, Haengseok Song, Dong Ryul Lee, Woo Sik Lee and Sang Woo Lyu

    Citation: Stem Cell Research & Therapy 2020 11:255

    Content type: Research

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  20. Human chronic graft-versus-host disease (CGVHD) shares clinical characteristics with a murine sclerodermatous GVHD (Scl-GVHD, B10.D2 → BALB/c) model that is characterized by skin and lung fibrosis. In this stu...

    Authors: Ji-Young Lim, Da-Bin Ryu, Tae Woo Kim, Sung-Eun Lee, Gyeongsin Park, Hyoung Kyu Yoon and Chang-Ki Min

    Citation: Stem Cell Research & Therapy 2020 11:254

    Content type: Research

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  21. Extracellular vesicles produced by bone marrow mesenchymal stem cells (BMSC-EVs) can play important roles in the repair of injured tissues. Though numerous studies have reported the effect of EVs on renal fibr...

    Authors: Zhengzhou Shi, Qi Wang, Youbo Zhang and Dapeng Jiang

    Citation: Stem Cell Research & Therapy 2020 11:253

    Content type: Research

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  22. Recently, extensive researches about stem cell-based therapies for ischemic stroke have been published; our review evaluated the efficacy and safety of stem cell-based therapies for ischemic stroke. Our review...

    Authors: Zhonghao Li, Xiaoke Dong, Min Tian, Chongchong Liu, Kaiyue Wang, Lili Li, Zunjing Liu and Jinmin Liu

    Citation: Stem Cell Research & Therapy 2020 11:252

    Content type: Review

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  23. GATA4 is an early cardiac-specific transcription factor, and endogenous GATA4-positive cells play a critical role in cardioprotection after myocardial injury. As functional paracrine units of therapeutic cells...

    Authors: Chunshu Hao, Zhengri Lu, Yuanyuan Zhao, Zhong Chen, Chengxing Shen, Genshan Ma and Lijuan Chen

    Citation: Stem Cell Research & Therapy 2020 11:251

    Content type: Research

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  24. Consumption of non-nutritive sweeteners (NNS) has been consistently associated with obesity and cardiometabolic disease in epidemiologic studies. Herein, we investigated effects of sucralose, a widely used NNS...

    Authors: Nabanita Kundu, Cleyton C. Domingues, Jay Patel, Mohammed Aljishi, Neeki Ahmadi, Mona Fakhri, Allison C. Sylvetsky and Sabyasachi Sen

    Citation: Stem Cell Research & Therapy 2020 11:250

    Content type: Research

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  25. The prevalence of kidney diseases is emerging as a public health problem. Stem cells (SCs), currently considered as a promising tool for therapeutic application, have aroused considerable interest and expectat...

    Authors: Dongwei Liu, Fei Cheng, Shaokang Pan and Zhangsuo Liu

    Citation: Stem Cell Research & Therapy 2020 11:249

    Content type: Review

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  26. Melanoma is a type of aggressive skin cancer with a poor survival rate. The resistance to conventional therapy of this disease is, at least in part, attributed to its cancer stem cell population. However, the ...

    Authors: Wenlin Wu, Chenxi Xu, Xiaobo Zhang, An Yu and Le Shu

    Citation: Stem Cell Research & Therapy 2020 11:248

    Content type: Research

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  27. Induced pluripotent stem cells (iPSCs) have enormous potential in developmental biology studies and in cellular therapies. Although extensively studied and characterized in human and murine models, iPSCs from ...

    Authors: Fabiana Fernandes Bressan, Vinícius Bassanezze, Laís Vicari de Figueiredo Pessôa, Chester Bittencourt Sacramento, Tathiane Maistro Malta, Simone Kashima, Paulo Fantinato Neto, Ricardo De Francisco Strefezzi, Naira Caroline Godoy Pieri, José Eduardo Krieger, Dimas Tadeu Covas and Flávio Vieira Meirelles

    Citation: Stem Cell Research & Therapy 2020 11:247

    Content type: Research

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  28. Cardiopulmonary bypass (CPB) results in severe lung injury via inflammation and endothelial injury. The aim of this study was to evaluate the effect of endothelial colony-forming cells (ECFCs) on lung injury i...

    Authors: Haibin Sun, Xiaoqing Zhao, Qihang Tai, Guangxiao Xu, Yingnan Ju and Wei Gao

    Citation: Stem Cell Research & Therapy 2020 11:246

    Content type: Research

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  29. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is considered a promising therapeutic approach for bone defect repair. However, during the transplantation procedure, the functions and viabilit...

    Authors: Yusi Guo, Xiaopei Chi, Yifan Wang, Boon Chin Heng, Yan Wei, Xuehui Zhang, Han Zhao, Ying Yin and Xuliang Deng

    Citation: Stem Cell Research & Therapy 2020 11:245

    Content type: Research

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  30. Pathological skin scars, caused by cesarean section, affected younger mothers esthetically and psychosocially and to some extent frustrated obstetricians and dermatologists. Umbilical cord mesenchymal stem cel...

    Authors: Dazhi Fan, Meng Zeng, Qing Xia, Shuzhen Wu, Shaoxin Ye, Jiaming Rao, Dongxin Lin, Huishan Zhang, Huiting Ma, Zhongchao Han, Xiaoling Guo and Zhengping Liu

    Citation: Stem Cell Research & Therapy 2020 11:244

    Content type: Research

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  31. In our previous study, a venom-based peptide named Gonearrestide (also named P13) was identified and demonstrated with an effective inhibition in the proliferation of colon cancer cells. In this study, we expl...

    Authors: Rui Ma, Zhili Ren, Bin Li, Shirley W. I. Siu, Guokai Chen and Hang Fai Kwok

    Citation: Stem Cell Research & Therapy 2020 11:243

    Content type: Research

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  32. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Hongtao Wang, Mengge Wang, Yu Wang, Yuqi Wen, Xiaoyuan Chen, Dan Wu, Pei Su, Wen Zhou, Lihong Shi and Jiaxi Zhou

    Citation: Stem Cell Research & Therapy 2020 11:242

    Content type: Correction

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    The original article was published in Stem Cell Research & Therapy 2020 11:147

  33. Mesenchymal stem cells (MSCs) have become a promising candidate for cell-based immune therapy for acute rejection (AR) after heart transplantation due to possessing immunomodulatory properties. In this study, ...

    Authors: Chao Gao, Xiaodong Wang, Jian Lu, Zhilin Li, Haowen Jia, Minghao Chen, Yuchen Chang, Yanhong Liu, Peiyuan Li, Baotong Zhang, Xuezhi Du and Feng Qi

    Citation: Stem Cell Research & Therapy 2020 11:241

    Content type: Research

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  34. Many studies have shown that long noncoding RNAs (lncRNAs) are closely related to the stimulation of osteogenic differentiation of adipose-derived stem cells (ADSCs) and the prevention of osteoporosis. Current...

    Authors: Zheng-liang Shi, Hua Zhang, Zhi-yong Fan, Wei Ma, Yong-zhou Song, Ming Li, Tong-qiu Li, Shu-xing Cao and Guo-jun Feng

    Citation: Stem Cell Research & Therapy 2020 11:240

    Content type: Research

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  35. The identification of endometrial stem/progenitor cells in a high turnover rate tissue suggests that a well-orchestrated underlying network controls the behaviour of these stem cells. The thickness of the endo...

    Authors: Shan Xu, Rachel W. S. Chan, Tianqi Li, Ernest H. Y. Ng and William S. B. Yeung

    Citation: Stem Cell Research & Therapy 2020 11:239

    Content type: Research

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  36. Pluripotent stem cells present the ability to self-renew and undergo differentiation into any cell type building an organism. Importantly, a lot of evidence on embryonic stem cell (ESC) differentiation comes f...

    Authors: Anita Florkowska, Igor Meszka, Magdalena Zawada, Diana Legutko, Tomasz J. Proszynski, Katarzyna Janczyk-Ilach, Wladyslawa Streminska, Maria A. Ciemerych and Iwona Grabowska

    Citation: Stem Cell Research & Therapy 2020 11:238

    Content type: Research

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  37. Although it has been preclinically suggested that adipose tissue-derived mesenchymal stem cell (ADSC)-based therapy could effectively treat chronic liver diseases, the hepatic engraftment of ADSCs is still ext...

    Authors: Naishun Liao, Yingjun Shi, Yingchao Wang, Fangyu Liao, Bixing Zhao, Youshi Zheng, Yongyi Zeng, Xiaolong Liu and Jingfeng Liu

    Citation: Stem Cell Research & Therapy 2020 11:237

    Content type: Research

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  38. Dental pulp stem cells (DPSCs) have high proliferation and multi-differentiation capabilities that maintain their functionality after cryopreservation. In our previous study, we demonstrated that cryopreserved...

    Authors: Masaki Hata, Maiko Omi, Yasuko Kobayashi, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Eriko Makino, Saki Kanada, Tomokazu Saiki, Tasuku Ohno, Yuka Imanishi, Tatsuhito Himeno, Hideki Kamiya, Jiro Nakamura, Shogo Ozawa, Ken Miyazawa…

    Citation: Stem Cell Research & Therapy 2020 11:236

    Content type: Research

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  39. We would like to thank for the interest for the article and comments in the response. We believe that cell therapy may offer a treatment for severe voice problems in patients with vocal fold scarring and MSC t...

    Authors: Stellan Hertegård and Katarina LeBlanc

    Citation: Stem Cell Research & Therapy 2020 11:235

    Content type: Commentary

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    The Commentary to this article has been published in Stem Cell Research & Therapy 2020 11:173

  40. Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers. Current NK therapies usi...

    Authors: Keerthana Shankar, Christian M. Capitini and Krishanu Saha

    Citation: Stem Cell Research & Therapy 2020 11:234

    Content type: Review

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  41. Degeneration of smooth muscles in sphincters can cause debilitating diseases such as fecal incontinence. Skeletal muscle-derived cells have been effectively used in clinics for the regeneration of the skeletal...

    Authors: Marco Thurner, Martin Deutsch, Katrin Janke, Franka Messner, Christina Kreutzer, Stanislav Beyl, Sébastien Couillard-Després, Steffen Hering, Jakob Troppmair and Rainer Marksteiner

    Citation: Stem Cell Research & Therapy 2020 11:233

    Content type: Research

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  42. Preeclampsia (PE) is a frequently occurring pregnancy disorder in the placenta, which results in various maternal and fetal complications. The current study aims to evaluate the role of extracellular vesicles ...

    Authors: Jinhui Cui, Xinjuan Chen, Shuo Lin, Ling Li, Jianhui Fan, Hongying Hou and Ping Li

    Citation: Stem Cell Research & Therapy 2020 11:231

    Content type: Research

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  43. Proliferation and transdifferentiation of lung stem cells (LSCs) could promote lung injury repair. The distal airways of the lung are innervated by the vagus nerve. Vagal-alpha7 nicotinic acetylcholine recepto...

    Authors: Xiaoyan Chen, Caiqi Zhao, Cuiping Zhang, Qingmei Li, Jie Chen, Lianping Cheng, Jian Zhou, Xiao Su and Yuanlin Song

    Citation: Stem Cell Research & Therapy 2020 11:230

    Content type: Research

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  44. To investigate the therapeutic effect of human dental pulp stem cells (DPSCs) transfected with adenovirus expressing hepatocyte growth factor (HGF) in a mouse model of collagen-induced arthritis (CIA).

    Authors: Xiwen Dong, Fanxuan Kong, Chao Liu, Shiyun Dai, Yuning Zhang, Fengjun Xiao, Huan Zhang, Chu-Tse Wu and Hua Wang

    Citation: Stem Cell Research & Therapy 2020 11:229

    Content type: Research

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  45. The beneficial functions of bone marrow mesenchymal stem cells (BM-MSCs) decline with decreased cell survival, limiting their therapeutic efficacy for myocardial infarction (MI). Irisin, a novel myokine which ...

    Authors: Jingyu Deng, Ning Zhang, Yong Wang, Chao Yang, Yabin Wang, Chao Xin, Jinming Zhao, Zhitao Jin, Feng Cao and Zheng Zhang

    Citation: Stem Cell Research & Therapy 2020 11:228

    Content type: Research

    Published on:

  46. Bone marrow mesenchymal stem cells (BMSCs) exhibit the capacity to self-renew and differentiate into multi-lineage cell types, including osteoblasts, which are crucial regulators of fracture healing. Thus, thi...

    Authors: Xueliang Zhang, Yongping Wang, Haiyan Zhao, Xingwen Han, Tong Zhao, Peng Qu, Guangjie Li and Wenji Wang

    Citation: Stem Cell Research & Therapy 2020 11:227

    Content type: Research

    Published on:

  47. Adipose-derived mesenchymal stem cells (ADMSCs) have attracted widespread interest as cell-based tissue repair systems. To obtain adequate quantities of ADMSCs for therapeutic applications, extensive in vitro ...

    Authors: Qiliang Yin, Na Xu, Dongsheng Xu, Mingxin Dong, Xiumin Shi, Yan Wang, Zhuo Hao, Shuangshuang Zhu, Donghai Zhao, Haofan Jin and Wensen Liu

    Citation: Stem Cell Research & Therapy 2020 11:226

    Content type: Research

    Published on:

  48. Acetaminophen (APAP) overdose is the common cause of acute liver failure (ALF) due to the oxidative damage of multiple cellular components. This study aimed to investigate whether plasma membrane vesicles (PMV...

    Authors: Mei-jia Lin, Shuang Li, Lu-jun Yang, Dan-yan Ye, Li-qun Xu, Xin Zhang, Ping-nan Sun and Chi-ju Wei

    Citation: Stem Cell Research & Therapy 2020 11:225

    Content type: Research

    Published on:

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