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  1. Content type: Research

    This study was aimed to investigate the role and specific molecular mechanism of HIF1A-AS2/miR-665/IL6 axis in regulating osteogenic differentiation of adipose-derived stem cells (ASCs) via the PI3K/Akt signal...

    Authors: Ruoyu Wu, Jihao Ruan, Yongjin Sun, Mengyu Liu, Zhuang Sha, Cunyi Fan and Qingkai Wu

    Citation: Stem Cell Research & Therapy 2018 9:348

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  2. Content type: Research

    Millions of people are affected with retinal diseases that eventually cause blindness, and retinal progenitor cell (RPC) transplantation is a promising therapeutic avenue. However, RPC expansion and the underl...

    Authors: Caixia Jin, Qingjian Ou, Zongyi Li, Juan Wang, Jieping Zhang, Haibin Tian, Jing-Ying Xu, Furong Gao, Lixia Lu and Guo-Tong Xu

    Citation: Stem Cell Research & Therapy 2018 9:346

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  3. Content type: Research

    Renal ischemia–reperfusion (I/R) injury is a major cause of acute kidney injury (AKI), which is associated with high morbidity and mortality. AKI is a serious and costly medical condition. Effective therapy fo...

    Authors: Wen-Ching Shen, Yu-Hsiang Chou, Hsiang-Po Huang, Jenn-Feng Sheen, Shih-Chieh Hung and Hsin-Fu Chen

    Citation: Stem Cell Research & Therapy 2018 9:344

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  4. Content type: Research

    Basic fibroblast growth factor (bFGF) regulates maintenance of stemness and modulation of osteo/odontogenic differentiation and mineralization in stem cells from human exfoliated deciduous teeth (SHEDs). Miner...

    Authors: Nunthawan Nowwarote, Waleerat Sukarawan, Prasit Pavasant, Brian L. Foster and Thanaphum Osathanon

    Citation: Stem Cell Research & Therapy 2018 9:345

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  5. Content type: Research

    Bone marrow-derived mesenchymal stem cells (BMSCs) are gradually getting attention because of its multi-directional differentiation potential, hematopoietic support, and promotion of stem cell implantation. Ho...

    Authors: Lihong Wang, Xianjing Han, Guojing Qu, Le Su, Baoxiang Zhao and Junying Miao

    Citation: Stem Cell Research & Therapy 2018 9:343

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  6. Content type: Research

    The Wnt/β-catenin signaling pathway plays an important role in the development of second heart field (SHF Isl1+) that gives rise to the anterior heart field (AHF) cardiac progenitor cells (CPCs) for the format...

    Authors: Yong Fan, Beatrice Xuan Ho, Jeremy Kah Sheng Pang, Nicole Min Qian Pek, Jin Hui Hor, Shi-Yan Ng and Boon-Seng Soh

    Citation: Stem Cell Research & Therapy 2018 9:338

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  7. Content type: Research

    As the implantation and long-term existence of tumor-specific T cells in host are the prerequisite for adoptive immunotherapy, memory stem T cells (TSCM) with self-renewal and differentiation capacity show the gr...

    Authors: Liping Guan, Xiaoyi Li, Jiali Wei, Zhihui Liang, Jing Yang, Xiufang Weng and Xiongwen Wu

    Citation: Stem Cell Research & Therapy 2018 9:337

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  8. Content type: Research

    During differentiation of stem cells, it is recognized that molecular mechanisms of transcription factors manage stem cells towards the intended lineage. In this study, using microarray-based technology, gene ...

    Authors: Se Won Yi, Hye Jin Kim, Hyun Jyung Oh, Heejun Shin, Jung Sun Lee, Ji Sun Park and Keun-Hong Park

    Citation: Stem Cell Research & Therapy 2018 9:341

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  9. Content type: Research

    Apelin plays a key beneficial role in energy metabolism by increasing glucose uptake and insulin sensitivity; however, apelin has a short half-life because it is rapidly cleared from the circulation limiting i...

    Authors: Lian Ru Gao, Ning Kun Zhang, Yan Zhang, Yu Chen, Li Wang, Ying Zhu and Hai Hong Tang

    Citation: Stem Cell Research & Therapy 2018 9:339

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  10. Content type: Research

    Three-dimensional (3D) floating culture clumps of mesenchymal stem cell (MSC)/extracellular matrix (ECM) complexes (C-MSCs) consist of cells and self-produced ECM. Previous studies have demonstrated that C-MSC...

    Authors: Nao Komatsu, Mikihito Kajiya, Souta Motoike, Manabu Takewaki, Susumu Horikoshi, Tomoyuki Iwata, Kazuhisa Ouhara, Katsuhiro Takeda, Shinji Matsuda, Tsuyoshi Fujita and Hidemi Kurihara

    Citation: Stem Cell Research & Therapy 2018 9:342

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  11. Content type: Review

    Mesenchymal stem cells (MSC) comprise a heterogeneous population of rapidly proliferating cells that can be isolated from adult (e.g., bone marrow, adipose tissue) as well as fetal (e.g., umbilical cord) tissu...

    Authors: Ioannis Christodoulou, Maria Goulielmaki, Marina Devetzi, Mihalis Panagiotidis, Georgios Koliakos and Vassilis Zoumpourlis

    Citation: Stem Cell Research & Therapy 2018 9:336

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  12. Content type: Research

    Despite considerable progress in the development of methods for hematopoietic differentiation, efficient generation of transplantable hematopoietic stem cells (HSCs) and other genuine functional blood cells fr...

    Authors: Mengge Wang, Hongtao Wang, Yuqi Wen, Xiaoyuan Chen, Xin Liu, Jie Gao, Pei Su, Yuanfu Xu, Wen Zhou, Lihong Shi and Jiaxi Zhou

    Citation: Stem Cell Research & Therapy 2018 9:340

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  13. Content type: Research

    Silicosis is a common occupational disease, characterized by silicotic nodules and diffuse pulmonary fibrosis. We demonstrated an anti-fibrotic effect of bone marrow mesenchymal stem cells (BMSCs) in silica-in...

    Authors: Xiaoli Li, Guoliang An, Yan Wang, Di Liang, Zhonghui Zhu and Lin Tian

    Citation: Stem Cell Research & Therapy 2018 9:335

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  14. Content type: Research

    Stem cells from apical papilla (SCAP) are a subpopulation of mesenchymal stem cells (MSCs) isolated from the apical papilla of the developing tooth root apex of human teeth. Because of their osteogenic/dentino...

    Authors: Yosuke Tanaka, Soichiro Sonoda, Haruyoshi Yamaza, Sara Murata, Kento Nishida, Shion Hama, Yukari Kyumoto-Nakamura, Norihisa Uehara, Kazuaki Nonaka, Toshio Kukita and Takayoshi Yamaza

    Citation: Stem Cell Research & Therapy 2018 9:334

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  15. Content type: Research

    Cell-based regenerative medicine therapies are now frequently tested in clinical trials. In many conditions, cell therapies are administered systemically, but there is little understanding of their fate, and a...

    Authors: Lauren Scarfe, Arthur Taylor, Jack Sharkey, Rachel Harwood, Michael Barrow, Joan Comenge, Lydia Beeken, Cai Astley, Ilaria Santeramo, Claire Hutchinson, Lorenzo Ressel, Jon Smythe, Eric Austin, Raphael Levy, Matthew J. Rosseinsky, Dave J. Adams…

    Citation: Stem Cell Research & Therapy 2018 9:332

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  16. Content type: Research

    Mesenchymal stem cells (MSCs) are found in synovial fluid (SF) and can easily be harvested during arthrocentesis or arthroscopy. However, SF-MSC characterization and chondrogenicity in collagen sponges have be...

    Authors: Paul Neybecker, Christel Henrionnet, Elise Pape, Didier Mainard, Laurent Galois, Damien Loeuille, Pierre Gillet and Astrid Pinzano

    Citation: Stem Cell Research & Therapy 2018 9:329

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  17. Content type: Research

    Bone tissue engineering is not widely used in clinical treatment. Two main reasons hide behind this: (1) the seed cells are difficult to obtain and (2) the process of tissue engineering bone construction is to...

    Authors: Dingyu Wu, Zhenxing Wang, Jinbing Wang, Yingnan Geng, Zhanzhao Zhang, Yu Li, Qiannan Li, Zhiwei Zheng, Yilin Cao and Zhi-Yong Zhang

    Citation: Stem Cell Research & Therapy 2018 9:331

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  18. Content type: Research

    Menstrual blood-derived endometrial stem cells (MenSCs) emerge as an ideal source for cell-based treatment in regenerative medicine and immunotherapy. However, the major obstacle is the low survival rate in ti...

    Authors: Jiang Du, Xinxing Zhu, Rui Guo, Zhihao Xu, Fang Fang Cheng, Qing Liu, Fen Yang, Lihong Guan, Yanli Liu and Juntang Lin

    Citation: Stem Cell Research & Therapy 2018 9:330

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  19. Content type: Research

    The tissue engineering of urinary bladder advances rapidly reflecting clinical need for a new kind of therapeutic solution for patients requiring urinary bladder replacement. Majority of the bladder augmentati...

    Authors: Marta Pokrywczynska, Arkadiusz Jundzill, Marta Rasmus, Jan Adamowicz, Daria Balcerczyk, Monika Buhl, Karolina Warda, Lukasz Buchholz, Maciej Gagat, Dariusz Grzanka and Tomasz Drewa

    Citation: Stem Cell Research & Therapy 2018 9:328

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  20. Content type: Research

    Lung cancer stem cells have the ability to self-renew and are resistant to conventional chemotherapy. MicroRNAs (miRNAs) regulate and control the expression and function of many target genes; therefore, miRNA ...

    Authors: Xiaoyuan Wang, Qingwei Meng, Wenbo Qiao, Ruishuang Ma, Weiwei Ju, Jing Hu, Hailing Lu, Jianqi Cui, Zhao Jin, Yanbin Zhao and Yan Wang

    Citation: Stem Cell Research & Therapy 2018 9:327

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  21. Content type: Research

    Regenerative medicine potentially offers the opportunity for curing male infertility. Native extracellular matrix (ECM) creates a reconstruction platform to replace the organs. In this study, we aimed to evalu...

    Authors: Elias Kargar-Abarghouei, Zahra Vojdani, Ashraf Hassanpour, Sanaz Alaee and Tahereh Talaei-Khozani

    Citation: Stem Cell Research & Therapy 2018 9:324

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  22. Content type: Research

    Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) have been shown to prevent brain damage and improve neurocognition following intraventricular hemorrhage (IVH). However, the molecular mech...

    Authors: Hyo Rim Ko, So Yoon Ahn, Yun Sil Chang, Inwoo Hwang, Taegwan Yun, Dong Kyung Sung, Se In Sung, Won Soon Park and Jee-Yin Ahn

    Citation: Stem Cell Research & Therapy 2018 9:326

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  23. Content type: Research

    Human muscle-derived stem cells (hMDSCs) have been shown to regenerate bone efficiently when they were transduced with Lenti-viral bone morphogenetic protein 2 (LBMP2). However, whether the age of hMDSCs and t...

    Authors: Xueqin Gao, Aiping Lu, Ying Tang, Johannes Schneppendahl, Andrea B. Liebowitz, Alex C. Scibetta, Elizabeth R. Morris, Haizi Cheng, Charles Huard, Sarah Amra, Bing Wang, Mary A. Hall, Walter R. Lowe and Johnny Huard

    Citation: Stem Cell Research & Therapy 2018 9:316

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  24. Content type: Research

    Early-stage diabetic retinopathy (DR) is characterized by neurovascular defects. In this study, we hypothesized that human adipose-derived stem cells (ASCs) positive for the pericyte marker CD140b, or their se...

    Authors: Sally L. Elshaer, William Evans, Mickey Pentecost, Raji Lenin, Ramesh Periasamy, Kumar Abhiram Jha, Shanta Alli, Jordy Gentry, Samuel M. Thomas, Nicolas Sohl and Rajashekhar Gangaraju

    Citation: Stem Cell Research & Therapy 2018 9:322

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  25. Content type: Short report

    The use of secretome may be a new strand of cell therapy, which is equal to or even superior to the injection of live cells, called cell-free therapy. In ovarian transplantation, this approach may be a therape...

    Authors: Luciana Lamarão Damous, Ana Elisa Teófilo Saturi de Carvalho, Juliana Sanajotti Nakamuta, Marcos Eiji Shiroma, Andressa Cristina Sposato Louzada, José Maria Soares-Jr, José Eduardo Krieger and Edmund C. Baracat

    Citation: Stem Cell Research & Therapy 2018 9:323

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  26. Content type: Research

    Developing cartilage constructed with the appropriate matrix composition and persistent chondrogenesis remains an enduring challenge in cartilage defects. Cartilage progenitor cell (CPC)-based tissue engineeri...

    Authors: Yahong Chen, Ke Xue, Xiaodie Zhang, Zhiwei Zheng and Kai Liu

    Citation: Stem Cell Research & Therapy 2018 9:318

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  27. Content type: Research article

    Better understanding of the signaling pathways that regulate human bone marrow stromal stem cell (hBMSC) differentiation into bone-forming osteoblasts is crucial for their clinical use in regenerative medicine...

    Authors: Nihal AlMuraikhi, Dalia Ali, Aliah Alshanwani, Radhakrishnan Vishnubalaji, Muthurangan Manikandan, Muhammad Atteya, Abdulaziz Siyal, Musaad Alfayez, Abdullah Aldahmash, Moustapha Kassem and Nehad M. Alajez

    Citation: Stem Cell Research & Therapy 2018 9:319

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  28. Content type: Review

    Mesenchymal stem cells (MSCs) are adult stromal cells with the capacity to differentiate into multiple types of cells. MSCs represent an attractive option in regenerative medicine due to their multifaceted abi...

    Authors: Guanguan Qiu, Guoping Zheng, Menghua Ge, Jiangmei Wang, Ruoqiong Huang, Qiang Shu and Jianguo Xu

    Citation: Stem Cell Research & Therapy 2018 9:320

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  29. Content type: Research

    Hepatocyte transplantation has been proposed as an effective treatment for patients with acute liver failure (ALF), but its application is limited by a severe shortage of donor livers. Human pluripotent stem c...

    Authors: Quan-Wen Liu, Qian-Yu Liu, Jing-Yuan Li, Li Wei, Kang-Kang Ren, Xiang-Cheng Zhang, Ting Ding, Ling Xiao, Wen-Jie Zhang, Han-You Wu and Hong-Bo Xin

    Citation: Stem Cell Research & Therapy 2018 9:321

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  30. Content type: Research

    Spermatogonial stem cell transplantation (SSCT) could become a fertility restoration tool for childhood cancer survivors. However, since in mice, the colonization efficiency of transplanted spermatogonial stem...

    Authors: Prashant Kadam, Elissavet Ntemou, Yoni Baert, Sven Van Laere, Dorien Van Saen and Ellen Goossens

    Citation: Stem Cell Research & Therapy 2018 9:317

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  31. Content type: Research

    Amyotrophic lateral sclerosis (ALS) represents a devastating, progressive, heterogeneous, and the most common motor neuron (MN) disease. To date, no cure has been available for the condition. Studies with tran...

    Authors: Xuejiao Sun, Jianyuan Song, Hailong Huang, Hong Chen and Kun Qian

    Citation: Stem Cell Research & Therapy 2018 9:315

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  32. Content type: Research

    We have shown that the differentiation of human-induced pluripotent stem cells (hiPSCs) into endothelial cells (ECs) is more efficient when performed with a 3-dimensional (3D) scaffold of biomaterial than in m...

    Authors: Liping Su, Xiaocen Kong, Szeyun Lim, Szejie Loo, Shihua Tan, Kiankeong Poh, James Dutton, Colin Stewart, Stuart Cook, Xiaofei Su, Jianhua Ma, Jianyi Zhang and Lei Ye

    Citation: Stem Cell Research & Therapy 2018 9:313

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  33. Content type: Research

    Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) exhibit strong and powerful potential in repairing different diseases. The expression profile of circular RNA (circRNA) provides valuable insight for re...

    Authors: Baolan Sun, Lei Shi, Qin Shi, Yao Jiang, Zhangyao Su, Xiaoqing Yang and Yuquan Zhang

    Citation: Stem Cell Research & Therapy 2018 9:314

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  34. Content type: Research

    Pulmonary fibrosis induced by silica dust is an irreversible, chronic, and fibroproliferative lung disease with no effective treatment at present. Previous studies have shown that early intervention with bone ...

    Authors: Enguo Zhang, Ye Yang, Shangya Chen, Cheng Peng, Martin F. Lavin, Abrey J. Yeo, Chao Li, Xiaoshan Liu, Yingjun Guan, Xinjing Du, Zhongjun Du and Hua Shao

    Citation: Stem Cell Research & Therapy 2018 9:311

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  35. Content type: Research

    The aim of this study was to evaluate the safety of mesenchymal stem cell infusion in patients with autoimmune diseases.

    Authors: Jun Liang, Huayong Zhang, Wei Kong, Wei Deng, Dandan Wang, Xuebing Feng, Cheng Zhao, Bingzhu Hua, Hong Wang and Lingyun Sun

    Citation: Stem Cell Research & Therapy 2018 9:312

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  36. Content type: Research

    The positive effects of human bone marrow–derived mesenchymal stem cells (hBM-MSCs) and minocycline on ischemic stroke models have been well described through numerous studies. The aim of this study was to eva...

    Authors: Dong Young Cho and Sin-Soo Jeun

    Citation: Stem Cell Research & Therapy 2018 9:309

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  37. Content type: Research

    Previous studies have demonstrated remarkable tropism of mesenchymal stem cells (MSCs) toward malignant gliomas, making these cells a potential vehicle for delivery of therapeutic agents to disseminated gliobl...

    Authors: Lorena Favaro Pavon, Tatiana Tais Sibov, Andrea Vieira de Souza, Edgar Ferreira da Cruz, Suzana M. F. Malheiros, Francisco Romero Cabral, Jean Gabriel de Souza, Pamela Boufleur, Daniela Mara de Oliveira, Silvia Regina Caminada de Toledo, Luciana C. Marti, Jackeline Moraes Malheiros, Fernando F. Paiva, Alberto Tannús, Sérgio Mascarenhas de Oliveira, Ana Marisa Chudzinski-Tavassi…

    Citation: Stem Cell Research & Therapy 2018 9:310

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  38. Content type: Research

    Medical management of the severe musculocutaneous radiation syndrome involves surgical intervention with debridement of necrotic tissue. Even when skin excision is replaced by specific plastic surgery, treatme...

    Authors: Christine Linard, Michel Brachet, Bruno L’homme, Carine Strup-Perrot, Elodie Busson, Michel Bonneau, Jean-Jacques Lataillade, Eric Bey and Marc Benderitter

    Citation: Stem Cell Research & Therapy 2018 9:299

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  39. Content type: Research

    Restoration of damaged tissues through the activation of endogenous progenitors is an attractive therapeutic option. A deep evaluation of the intrinsic stem/progenitor cell properties as well as the reciprocal...

    Authors: Claudia Lo Sicco, Daniele Reverberi, Federico Villa, Ulrich Pfeffer, Rodolfo Quarto, Ranieri Cancedda and Roberta Tasso

    Citation: Stem Cell Research & Therapy 2018 9:300

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  40. Content type: Review

    Autophagy plays a critical role in the dynamic growth of each cell through different conditions. It seems that this intracellular mechanism acts as a two-edged sword against the numerous cell insults. Previous...

    Authors: Mehdi Hassanpour, Aysa Rezabakhsh, Masoud Pezeshkian, Reza Rahbarghazi and Mohammad Nouri

    Citation: Stem Cell Research & Therapy 2018 9:305

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  41. Content type: Research

    Recent studies have demonstrated mesenchymal stem cells (MSCs) as effective mitochondrial donors with therapeutic success in multiple experimental models of human disease. MSCs obtained from different tissue s...

    Authors: Swati Paliwal, Rituparna Chaudhuri, Anurag Agrawal and Sujata Mohanty

    Citation: Stem Cell Research & Therapy 2018 9:298

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  42. Content type: Research

    Mesenchymal stem cell-derived conditioned medium (MSC-CM) has emerged as a promising cell-free tool for restoring degenerative diseases and treating traumatic injuries. The present study describes the effect o...

    Authors: Junghyun Park, Jung Han Lee, Byung Sun Yoon, Eun Kyoung Jun, Gilju Lee, In Yong Kim and Seungkwon You

    Citation: Stem Cell Research & Therapy 2018 9:293

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  43. Content type: Research

    The proangiogenic capacity of adipose tissue and its derivatives has been demonstrated in a variety of studies. The paracrine mechanism of the cellular component is considered to play a critical role in the re...

    Authors: Ziyou Yu, Yizuo Cai, Mingwu Deng, Dong Li, Xiangsheng Wang, Hongjie Zheng, Yuda Xu, Wei Li and Wenjie Zhang

    Citation: Stem Cell Research & Therapy 2018 9:294

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  44. Content type: Research

    Hyperbilirubinemia that occurs in pediatric liver diseases such as biliary atresia can result in the development of not only jaundice in the brain, eyes, and skin, but also tooth abnormalities including green ...

    Authors: Haruyoshi Yamaza, Soichiro Sonoda, Kazuaki Nonaka, Toshio Kukita and Takayoshi Yamaza

    Citation: Stem Cell Research & Therapy 2018 9:303

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  45. Content type: Research

    We recently demonstrated that intracellular xenogen-contaminated autologous MSCs (FBS) and non-xenogen-contaminated allogeneic (ALLO) MSCs caused an adverse clinical response after repeated intra-articular inj...

    Authors: Aileen L. Rowland, Jiajie Jessica Xu, Amanda Jo Joswig, Carl A. Gregory, Douglas F. Antczak, Kevin J. Cummings and Ashlee E. Watts

    Citation: Stem Cell Research & Therapy 2018 9:295

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  46. Content type: Research

    The generation of hematopoietic stem cells (HSCs) and blood cells from human embryonic stem cells (hESCs) is a major goal for regenerative medicine; however, the differentiation mechanisms are largely undefine...

    Authors: Pengfei Li, Mengyao Wu, Qiwang Lin, Shu Wang, Tong Chen and Hua Jiang

    Citation: Stem Cell Research & Therapy 2018 9:301

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