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  1. Research

    Generation of special autosomal dominant polycystic kidney disease iPSCs with the capability of functional kidney-like cell differentiation

    Human induced pluripotent stem cells (iPSCs) have been verified as a powerful cell model for the study of pathogenesis in hereditary disease. Autosomal dominant polycystic kidney disease (ADPKD) is caused by m...

    Jiahui Huang, Shumin Zhou, Xin Niu, Bin Hu, Qing Li, Feng Zhang, Xue Zhang, Xiujuan Cai, Yuanlei Lou, Fen Liu, Chenming Xu and Yang Wang

    Stem Cell Research & Therapy 2017 8:196

    Published on: 19 September 2017

  2. Short report

    Adipose-derived stem cell-released osteoprotegerin protects cardiomyocytes from reactive oxygen species-induced cell death

    The paracrine effect is likely the major mechanism of the adipose-derived stem cell (ASC)-mediated cardioprotective effect. However, the exact composition and nature of ASC-released paracrine factors remain el...

    Jiyun Lee, Seahyung Lee, Chang Youn Lee, Hyang-Hee Seo, Sunhye Shin, Jung-Won Choi, Sang Woo Kim, Jong-Chul Park, Soyeon Lim and Ki-Chul Hwang

    Stem Cell Research & Therapy 2017 8:195

    Published on: 19 September 2017

  3. Review

    The combination of stem cells and tissue engineering: an advanced strategy for blood vessels regeneration and vascular disease treatment

    Over the past years, vascular diseases have continued to threaten human health and increase financial burdens worldwide. Transplantation of allogeneic and autologous blood vessels is the most convenient treatm...

    Ying Wang, Pei Yin, Guang-Liang Bian, Hao-Yue Huang, Han Shen, Jun-Jie Yang, Zi-Ying Yang and Zhen-Ya Shen

    Stem Cell Research & Therapy 2017 8:194

    Published on: 15 September 2017

  4. Research

    Multipotent stromal cells/mesenchymal stem cells and fibroblasts combine to minimize skin hypertrophic scarring

    Transplantation of mesenchymal stem cells (MSC) has been proposed to improve wound healing. However, as these cells only transiently survive in the implantation site, the mechanisms underlying this beneficial ...

    Cecelia C. Yates, Melanie Rodrigues, Austin Nuschke, Zariel I Johnson, Diana Whaley, Donna Stolz, Joseph Newsome and Alan Wells

    Stem Cell Research & Therapy 2017 8:193

    Published on: 5 September 2017

  5. Research

    Adipose stem cells from chronic pancreatitis patients improve mouse and human islet survival and function

    Chronic pancreatitis has surgical options including total pancreatectomy to control pain. To avoid surgical diabetes, the explanted pancreas can have islets harvested and transplanted. Immediately following to...

    Lili Song, Zhen Sun, Do-sung Kim, Wenyu Gou, Charlie Strange, Huansheng Dong, Wanxing Cui, Gary Gilkeson, Katherine A. Morgan, David B. Adams and Hongjun Wang

    Stem Cell Research & Therapy 2017 8:192

    Published on: 30 August 2017

  6. Review

    Safety and effectiveness of stem cell therapies in early-phase clinical trials in stroke: a systematic review and meta-analysis

    Stem cells have demonstrated encouraging potential as reparative therapy for patients suffering from post-stroke disability. Reperfusion interventions in the acute phase of stroke have shown significant benefi...

    Anjali Nagpal, Fong Chan Choy, Stuart Howell, Susan Hillier, Fiona Chan, Monica A. Hamilton-Bruce and Simon A. Koblar

    Stem Cell Research & Therapy 2017 8:191

    Published on: 30 August 2017

  7. Research

    Term amniotic fluid: an unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications

    Mesenchymal stromal cells (MSCs) are currently being evaluated in numerous pre-clinical and clinical cell-based therapy studies. Furthermore, there is an increasing interest in exploring alternative uses of th...

    Roksana Moraghebi, Agnete Kirkeby, Patricia Chaves, Roger E. Rönn, Ewa Sitnicka, Malin Parmar, Marcus Larsson, Andreas Herbst and Niels-Bjarne Woods

    Stem Cell Research & Therapy 2017 8:190

    Published on: 25 August 2017

  8. Research

    Epigenetic reprogramming converts human Wharton’s jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators

    Lineage commitment of mesenchymal stem cells (MSCs) to cardiac differentiation is controlled by transcription factors that are regulated by epigenetic events, mainly histone deacetylation and promoter DNA meth...

    G. Bhuvanalakshmi, Frank Arfuso, Alan Prem Kumar, Arun Dharmarajan and Sudha Warrier

    Stem Cell Research & Therapy 2017 8:185

    Published on: 14 August 2017

  9. Research

    Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix

    Mesenchymal stem cell therapy for osteoarthritis (OA) has been widely investigated, but the mechanisms are still unclear. Exosomes that serve as carriers of genetic information have been implicated in many dis...

    Yafei Wang, Dongsheng Yu, Zhiming Liu, Fang Zhou, Jun Dai, Bingbing Wu, Jing Zhou, Boon Chin Heng, Xiao Hui Zou, Hongwei Ouyang and Hua Liu

    Stem Cell Research & Therapy 2017 8:189

    Published on: 14 August 2017

  10. Research

    Overexpression of miR-21 in stem cells improves ovarian structure and function in rats with chemotherapy-induced ovarian damage by targeting PDCD4 and PTEN to inhibit granulosa cell apoptosis

    Chemotherapy-induced premature ovarian failure (POF) is a severe complication affecting tumor patients at a childbearing age. Mesenchymal stem cells (MSCs) can partially restore the ovarian structure and funct...

    Xiafei Fu, Yuanli He, Xuefeng Wang, Dongxian Peng, Xiaoying Chen, Xinran Li and Qing Wang

    Stem Cell Research & Therapy 2017 8:187

    Published on: 14 August 2017

  11. Research

    Protein deubiquitinase USP7 is required for osteogenic differentiation of human adipose-derived stem cells

    Human adipose-derived stem cells (hASCs) are multipotent progenitor cells with self-renewal capabilities and multilineage differentiation potential, including osteogenesis. Although protein deubiquitinases hav...

    Yiman Tang, Longwei Lv, Wenyue Li, Xiao Zhang, Yong Jiang, Wenshu Ge and Yongsheng Zhou

    Stem Cell Research & Therapy 2017 8:186

    Published on: 14 August 2017

  12. Research

    Angiogenic potency evaluation of cell therapy candidates by a novel application of the in vitro aortic ring assay

    Due to limitations of current angiogenesis assays, we aimed to develop a novel application of the rat aortic ring assay to assess the angiogenic potential of mesenchymal stromal cells (MSCs). First-trimester h...

    Farwah Iqbal, Peter Szaraz, Matthew Librach, Andrée Gauthier-Fisher and Clifford L. Librach

    Stem Cell Research & Therapy 2017 8:184

    Published on: 14 August 2017

  13. Research

    Mesenchymal stromal cells ameliorate oxidative stress-induced islet endothelium apoptosis and functional impairment via Wnt4-β-catenin signaling

    Islet dysfunction and destruction are the common cause for both type 1 and type 2 diabetes mellitus (T2DM). The islets of Langerhans are highly vascularized miniorgans, and preserving the structural integrity ...

    Lingshu Wang, Li Qing, He Liu, Na Liu, Jingting Qiao, Chen Cui, Tianyi He, Ruxing Zhao, Fuqiang Liu, Fei Yan, Chuan Wang, Kai Liang, Xinghong Guo, Ying H. Shen, Xinguo Hou and Li Chen

    Stem Cell Research & Therapy 2017 8:188

    Published on: 14 August 2017

  14. Research

    Inhibitory effects of HNF4α on migration/maltransformation of hepatic progenitors: HNF4α-overexpressing hepatic progenitors for liver repopulation

    Although they are expandable in vitro, hepatic progenitors are immature cells and share many immunomarkers with hepatocellular carcinoma, raising potential concerns regarding maltransformation after transplant...

    Ping Wang, Min Cong, Tianhui Liu, Hufeng Xu, Lin Wang, Guangyong Sun, Aiting Yang, Dong Zhang, Jian Huang, Yameng Sun, Wenshan Zhao, Hong Ma, Jidong Jia and Hong You

    Stem Cell Research & Therapy 2017 8:183

    Published on: 14 August 2017

  15. Research

    Determination of optimized oxygen partial pressure to maximize the liver regenerative potential of the secretome obtained from adipose-derived stem cells

    A hypoxic-preconditioned secretome from stem cells reportedly promotes the functional and regenerative capacity of the liver more effectively than a control secretome. However, the optimum oxygen partial press...

    Sang Chul Lee, Kee-Hwan Kim, Ok-Hee Kim, Sang Kuon Lee, Ha-Eun Hong, Seong Su Won, Sang-Jin Jeon, Byung Jo Choi, Wonjun Jeong and Say-June Kim

    Stem Cell Research & Therapy 2017 8:181

    Published on: 3 August 2017

  16. Research

    Curcumin induces therapeutic angiogenesis in a diabetic mouse hindlimb ischemia model via modulating the function of endothelial progenitor cells

    Neovascularization is impaired in diabetes mellitus, which leads to the development of peripheral arterial disease and is mainly attributed to the dysfunction of endothelial progenitor cells (EPCs). Previous s...

    Jinzhi You, Jiacheng Sun, Teng Ma, Ziying Yang, Xu Wang, Zhiwei Zhang, Jingjing Li, Longgang Wang, Masaaki Ii, Junjie Yang and Zhenya Shen

    Stem Cell Research & Therapy 2017 8:182

    Published on: 3 August 2017

  17. Research

    CD106 is a novel mediator of bone marrow mesenchymal stem cells via NF-κB in the bone marrow failure of acquired aplastic anemia

    Acquired aplastic anemia (AA) is characterized by deficiency or dysfunction of the bone marrow (BM) microenvironment. However, little is known about the impairment of BM-derived mesenchymal stem cells (MSCs) i...

    Shihong Lu, Meili Ge, Yizhou Zheng, Jianping Li, Xiaoming Feng, Sizhou Feng, Jinbo Huang, Ying Feng, Donglin Yang, Jun Shi, Fang Chen and Zhongchao Han

    Stem Cell Research & Therapy 2017 8:178

    Published on: 1 August 2017

  18. Research

    Mesenchymal stem cells derived from inflamed dental pulpal and gingival tissue: a potential application for bone formation

    Chronic periodontal disease is an infectious disease consisting of prolonged inflammation of the supporting tooth tissue and resulting in bone loss. Guided bone regeneration procedures have become common and s...

    Laura Tomasello, Rodolfo Mauceri, Antonina Coppola, Maria Pitrone, Giuseppe Pizzo, Giuseppina Campisi, Giuseppe Pizzolanti and Carla Giordano

    Stem Cell Research & Therapy 2017 8:179

    Published on: 1 August 2017

  19. Research

    Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristics

    Many reports have shown that various kinds of stem cells have the ability to recover premature ovarian aging (POA) function. Transplantation of human amniotic epithelial cells (hAECs) improves ovarian function...

    Chenyue Ding, Hong Li, Yun Wang, Fuxin Wang, Huihua Wu, Rulei Chen, Jinghuan Lv, Wei Wang and Boxian Huang

    Stem Cell Research & Therapy 2017 8:173

    Published on: 27 July 2017

  20. Research

    Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency

    Argininosuccinate synthase (ASS)1 is a urea cycle enzyme that catalyzes the conversion of citrulline and aspartate to argininosuccinate. Mutations in the ASS1 gene cause citrullinemia type I, a rare autosomal ...

    Maria Beatriz Herrera Sanchez, Sara Previdi, Stefania Bruno, Valentina Fonsato, Maria Chiara Deregibus, Sharad Kholia, Sara Petrillo, Emanuela Tolosano, Rossana Critelli, Marco Spada, Renato Romagnoli, Mauro Salizzoni, Ciro Tetta and Giovanni Camussi

    Stem Cell Research & Therapy 2017 8:176

    Published on: 27 July 2017

  21. Research

    Human dental pulp pluripotent-like stem cells promote wound healing and muscle regeneration

    Dental pulp represents an easily accessible autologous source of adult stem cells. A subset of these cells, named dental pulp pluripotent-like stem cells (DPPSC), shows high plasticity and can undergo multiple...

    Ester Martínez-Sarrà, Sheyla Montori, Carlos Gil-Recio, Raquel Núñez-Toldrà, Domiziana Costamagna, Alessio Rotini, Maher Atari, Aernout Luttun and Maurilio Sampaolesi

    Stem Cell Research & Therapy 2017 8:175

    Published on: 27 July 2017

  22. Research

    Harvesting multipotent progenitor cells from a small sample of tonsillar biopsy for clinical applications

    Human adult stem cells hold the potential for the cure of numerous conditions and degenerative diseases. They possess major advantages over pluripotent stem cells as they can be derived from donors at any age,...

    Raju Khatri, Michal Arad, Timothy Ortlip, Benjamin A. Portney, W. Alex Meltzer, Silviu Diaconu, Lorna E. Silipino, Ying Wang, David M. Kaetzel, Rodney J. Taylor and Michal Zalzman

    Stem Cell Research & Therapy 2017 8:174

    Published on: 27 July 2017

  23. Research

    Culturing and transcriptome profiling of progenitor-like colonies derived from adult mouse pancreas

    Transplantation of insulin-producing cells is considered an important diabetes therapy. Many research studies have shown that insulin-producing cells can be derived from the in-vitro cultured pancreatic coloni...

    Dongshen Ma, Shanshan Tang, Jing Song, Qiong Wu, Fangfang Zhang, Yun Xing, Yi Pan, Yanfeng Zhang, Jingwei Jiang, Yubin Zhang and Liang Jin

    Stem Cell Research & Therapy 2017 8:172

    Published on: 26 July 2017

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