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  1. Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is widely used as a curative treatment strategy for most types of hematological diseases. However, strategies for enhancing the graft versus ...

    Authors: Ying Yang, Ming Zhang, Mengqi Li, Yingchun Li, Wei Yang, Zhuogang Liu and Hongtao Wang
    Citation: Stem Cell Research & Therapy 2022 13:485
  2. Anti-inflammatory polarized macrophages are reported to alleviate systemic lupus erythematosus (SLE). Our previous studies have demonstrated that exosomes from adipose-derived stem cells promote the anti-infla...

    Authors: Mingchao Zhang, Takerra K. Johnson-Stephenson, Weiran Wang, Yang Wang, Jing Li, Limin Li, Ke Zen, Xi Chen and Dihan Zhu
    Citation: Stem Cell Research & Therapy 2022 13:484
  3. Mesenchymal stem cells (MSCs) may be one of candidates for disease-modifying therapy in Parkinsonian diseases. As knowledge regarding the therapeutic properties of MSCs accumulates, some obstacles still remain...

    Authors: Jin Young Shin, Dong-Yeol Kim, Jieun Lee, Yu Jin Shin, Yi Seul Kim and Phil Hyu Lee
    Citation: Stem Cell Research & Therapy 2022 13:483
  4. Advancements in adoptive cell therapy over the last four decades have revealed various new therapeutic strategies, such as chimeric antigen receptors (CARs), which are dedicated immune cells that are engineere...

    Authors: Ali Keshavarz, Ali Salehi, Setareh Khosravi, Yasaman Shariati, Navid Nasrabadi, Mohammad Saeed Kahrizi, Sairan Maghsoodi, Amirhossein Mardi, Ramyar Azizi, Samira Jamali and Farnoush Fotovat
    Citation: Stem Cell Research & Therapy 2022 13:482
  5. The most serious condition of male infertility is complete Sertoli cell-only syndrome (SCOS), which refers to the lack of all spermatogenic cells in the testes. The genetic cause of SCOS remains to be explored...

    Authors: Xiaotong Wang, Zili Li, Mengyuan Qu, Chengliang Xiong and Honggang Li
    Citation: Stem Cell Research & Therapy 2022 13:480
  6. Mesenchymal stromal/stem cells (MSCs) have been intensively investigated in both pre-clinical and clinical studies. However, the therapeutic efficacy varies resulting from the heterogenicity of MSCs. Therefore...

    Authors: Lingyun Li, Lei Yang, Xian Chen, Xiangjuan Chen, Lianghui Diao, Yong Zeng and Jianyong Xu
    Citation: Stem Cell Research & Therapy 2022 13:479
  7. Human-induced pluripotent stem cell-derived retinal organoids are a valuable tool for disease modelling and therapeutic development. Many efforts have been made over the last decade to optimise protocols for t...

    Authors: Carla Sanjurjo-Soriano, Nejla Erkilic, Krishna Damodar, Hassan Boukhaddaoui, Michalitsa Diakatou, Marcela Garita-Hernandez, Daria Mamaeva, Gregor Dubois, Zhour Jazouli, Carla Jimenez-Medina, Olivier Goureau, Isabelle Meunier and Vasiliki Kalatzis
    Citation: Stem Cell Research & Therapy 2022 13:478
  8. Mesenchymal stem cells (MSCs) secrete paracrine factors and extracellular matrix proteins that contribute to their ability to support tissue healing and regeneration. Both the transcriptome and the secretome o...

    Authors: Drew W. Koch, Lauren V. Schnabel, Ilene M. Ellis, Rowan E. Bates and Alix K. Berglund
    Citation: Stem Cell Research & Therapy 2022 13:477
  9. Insulin producing cells generated by liver cell transdifferentiation, could serve as an attractive source for regenerative medicine. The present study assesses the relationship between DNA methylation pTFs ind...

    Authors: Adi Har-Zahav, Daniela Lixandru, David Cheishvili, Ioan Valentin Matei, Ioana Raluca Florea, Veronica Madalina Aspritoiu, Inna Blus-Kadosh, Irit Meivar-Levy, Andreea Madalina Serban, Irinel Popescu, Moshe Szyf, Sarah Ferber and Simona Olimpia Dima
    Citation: Stem Cell Research & Therapy 2022 13:476
  10. Crohn's disease (CD) is a chronic non-specific inflammatory bowel disease. Current CD therapeutics cannot fundamentally change the natural course of CD. Therefore, it is of great significance to find new treat...

    Authors: Fan Yang, Beibei Ni, Qiuli Liu, Fangping He, Li Li, Xuemei Zhong, Xiaofan Zheng, Jianxi Lu, Xiaoyan Chen, Huizhu Lin, Ruixuan Xu, Yizhan He, Qi Zhang, Xiaoguang Zou and Wenjie Chen
    Citation: Stem Cell Research & Therapy 2022 13:475
  11. The massive loss of follicles in the early stage of ovarian tissue transplantation is considered a significant restriction to the efficacy of ovarian tissue cryopreservation (OTC) and transplantation (OT). The...

    Authors: Jiaojiao Cheng, Xiangyan Ruan, Yanglu Li, Juan Du, Fengyu Jin, Muqing Gu, Qi Zhou, Xin Xu, Yu Yang, Husheng Wang and Alfred Otto Mueck
    Citation: Stem Cell Research & Therapy 2022 13:474
  12. More than 40% patients with diffuse large B cell lymphoma (DLBCL) experienced relapse or refractory (R/R) lymphoma after the standard first R-CHOP therapy. IL-6 was reportedly associated with chemotherapy resi...

    Authors: Jiayi Zhang, Minglu Zhong, Weijie Zhong, Yanfei Lan, Zhaohu Yuan, Yuyou Duan and Yaming Wei
    Citation: Stem Cell Research & Therapy 2022 13:473
  13. Cell therapy is the frontier technology of biotechnology innovation and the most promising method for the treatment of refractory diseases such as tumours. However, cell therapy has disadvantages, such as toxi...

    Authors: Caifeng Li, Zhao Cui, Shiwen Deng, Peng Chen, Xianyu Li and Hongjun Yang
    Citation: Stem Cell Research & Therapy 2022 13:472
  14. We previously established a human mesenchymal stem cell (MSC) line that was modified to express trophic factors. Transplanting a cell sheet produced from this line in an amyotrophic lateral sclerosis mouse mod...

    Authors: Naoto Honda, Yasuhiro Watanabe, Yuta Tokuoka and Ritsuko Hanajima
    Citation: Stem Cell Research & Therapy 2022 13:470
  15. Regularly discarded lip tissue obtained from corrective surgeries to close the cleft lip represents an easily accessible and rich source for the isolation of primary fibroblasts. Primary fibroblasts have been ...

    Authors: Ludovica Parisi, Silvia Rihs, Giorgio C. La Scala, Isabelle Schnyder, Christos Katsaros and Martin Degen
    Citation: Stem Cell Research & Therapy 2022 13:469
  16. Human-induced pluripotent stem cell (hiPSC)-derived functional hepatic endoderm (HE) is supposed to be an alternative option for replacement therapy for end-stage liver disease. However, the high heterogeneity...

    Authors: Fang Bai, Jinliang Duan, Daopeng Yang, Xingqiang Lai, Xiaofeng Zhu, Xiaoshun He and Anbin Hu
    Citation: Stem Cell Research & Therapy 2022 13:468
  17. Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1, also known as TAZ) are two key transcription co-activators of the Hippo pathway. Both were originally characteriz...

    Authors: Nattaya Damkham, Chanchao Lorthongpanich, Phatchanat Klaihmon, Usaneeporn Lueangamornnara, Pakpoom Kheolamai, Kongtana Trakarnsanga and Surapol Issaragrisil
    Citation: Stem Cell Research & Therapy 2022 13:467
  18. Dental follicle stem cells (DFSCs) show mesenchymal stem cell properties with the potential for alveolar bone regeneration. Stem cell properties can be impaired by reactive oxygen species (ROS), prompting us t...

    Authors: Zhaosong Meng, Jiacheng Liu, Zhipeng Feng, Shuling Guo, Mingzhe Wang, Zheng Wang, Zhe Li, Hongjie Li and Lei Sui
    Citation: Stem Cell Research & Therapy 2022 13:466
  19. Inflammatory bowel diseases (IBD) are chronic relapsing–remitting inflammatory diseases of the gastrointestinal tract that are typically categorized into two subtypes: Crohn's disease (CD) and ulcerative colit...

    Authors: Yixin Ye, Xiaomei Zhang, Dongsheng Su, Yushuang Ren, Fuyi Cheng, Yunqi Yao, Gang Shi, Yanhong Ji, Shuang Chen, Pengyi Shi, Lei Dai, Xiaolan Su and Hongxin Deng
    Citation: Stem Cell Research & Therapy 2022 13:465
  20. Small airway infections caused by respiratory viruses are some of the most prevalent causes of illness and death. With the recent worldwide pandemic due to the severe acute respiratory syndrome coronavirus 2 (...

    Authors: Taylor Do, Lilly Synan, Gibran Ali and Heather Gappa-Fahlenkamp
    Citation: Stem Cell Research & Therapy 2022 13:464
  21. Urethral stricture and reconstruction are one of the thorny difficult problems in the field of urology. The continuous development of tissue engineering and biomaterials has given new therapeutic thinking to t...

    Authors: Zhenpeng Zhu, Jiayu Yang, Xing Ji, Zicheng Wang, Chengxiang Dai, Suke Li, Xuesong Li, Yajie Xie, Yudong Zheng, Jian Lin and Liqun Zhou
    Citation: Stem Cell Research & Therapy 2022 13:463
  22. Critical limb ischemia (CLI), the terminal stage of peripheral arterial disease (PAD), is characterized by an extremely high risk of amputation and vascular issues, resulting in severe morbidity and mortality....

    Authors: Zeinab Shirbaghaee, Mohammad Hassani, Saeed Heidari Keshel and Masoud Soleimani
    Citation: Stem Cell Research & Therapy 2022 13:462
  23. Hematopoietic stem cell transplantation (HSCT) is the main treatment for acute radiation sickness, especially after fatal radiation. The determination of HSCT for radiation patients is mainly based on radiatio...

    Authors: Shixiang Zhou, Yaqiong Li, Lexin He, Min Chen, Weihong Li, Ting Xiao, Jian Guan, Zhenhua Qi, Qi Wang, Siyuan Li, Pingkun Zhou and Zhidong Wang
    Citation: Stem Cell Research & Therapy 2022 13:461
  24. Orthodontic tooth movement inevitably induces cementum resorption, which is an urgent problem for orthodontists to confront. Human periodontal ligament stem cells (hPDLSCs) exert an important role in the ortho...

    Authors: Zuping Wu, Yuying He, Sirui Chen, Li Zhu, Jiahe Wang, Demao Zhang, Jing Xie, Shujuan Zou and Chenchen Zhou
    Citation: Stem Cell Research & Therapy 2022 13:460
  25. Over the last 2 decades, induced pluripotent stem cells (iPSCs) have had various potential applications in various medical research areas, from personalized medicine to disease treatment. Different cellular re...

    Authors: Azam Shamsian, Roxana Sahebnasagh, Amir Norouzy, Safin Hassan Hussein, Mohammad Hossein Ghahremani and Zahra Azizi
    Citation: Stem Cell Research & Therapy 2022 13:459
  26. Synovial membrane-derived mesenchymal progenitor cells (SM-MPCs) are a promising candidate for the cell-based treatment of osteoarthritis (OA) considering their in vitro and in vivo capacity for cartilage repa...

    Authors: M. Teunissen, N. S. Ahrens, L. Snel, R. Narcisi, S. A. Kamali, G. J. V. M. van Osch, B. P. Meij, S. C. Mastbergen, K. Sivasubramaniyan and M. A. Tryfonidou
    Citation: Stem Cell Research & Therapy 2022 13:457
  27. The available therapeutic options for large bone defects remain extremely limited, requiring new strategies to accelerate bone healing. Genetically modified bone mesenchymal stem cells (BMSCs) with enhanced os...

    Authors: Lijun Li, Yibo Wang, Zhongxiang Wang, Deting Xue, Chengxin Dai, Xiang Gao, Jianfei Ma, Kai Hang and Zhijun Pan
    Citation: Stem Cell Research & Therapy 2022 13:456
  28. While rapid healing of diabetic foot ulcers (DFUs) is highly desirable to avoid infections, amputations and life-threatening complications, DFUs often respond poorly to standard treatment. GMP-manufactured ski...

    Authors: Andreas Kerstan, Kathrin Dieter, Elke Niebergall-Roth, Sabrina Klingele, Michael Jünger, Christoph Hasslacher, Georg Daeschlein, Lutz Stemler, Ulrich Meyer-Pannwitt, Kristin Schubert, Gerhard Klausmann, Titus Raab, Matthias Goebeler, Korinna Kraft, Jasmina Esterlechner, Hannes M. Schröder…
    Citation: Stem Cell Research & Therapy 2022 13:455
  29. Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-derived RPE) are a promising source for cell-replacement therapy to treat retinal degenerative diseases, but research on RPE cryopreserv...

    Authors: Ting Zhang, Xianyu Huang, Sujun Liu, Xinyue Bai, Xinyue Zhu, Dennis O. Clegg, Mei Jiang and Xiaodong Sun
    Citation: Stem Cell Research & Therapy 2022 13:454
  30. Circular RNAs (circRNAs) are a new type of stable noncoding RNA and have been proven to play a crucial role in osteoporosis. This study explored the role and mechanism of hsa_circ_0001485 in osteogenic differe...

    Authors: Shan-Chuang Chen, Tao Jiang, Qi-Yu Liu, Zi-Tao Liu, Yu-Fei Su and Hai-Tao Su
    Citation: Stem Cell Research & Therapy 2022 13:453
  31. Multiple studies have reported that stem cell therapy has beneficial effects in animal models of intracerebral hemorrhage (ICH). However, this finding remains inconclusive. This study was performed to systemat...

    Authors: Chenchen Li, Haiyun Qin, Liuwang Zeng, Zhiping Hu and Chunli Chen
    Citation: Stem Cell Research & Therapy 2022 13:452
  32. Diabetic foot ulcer (DFU) is a serious chronic complication of diabetes mellitus that contributes to 85% of nontraumatic lower extremity amputations in diabetic patients. Preliminary clinical benefits have bee...

    Authors: Che Zhang, Li Huang, Xiaofen Wang, Xiaoya Zhou, Xiaoxian Zhang, Ling Li, Jieying Wu, Meng Kou, Cheguo Cai, Qizhou Lian and Xihui Zhou
    Citation: Stem Cell Research & Therapy 2022 13:451
  33. Erectile dysfunction (ED), as one of the most prevalent consequences in male diabetic patients, has a serious impact on men's physical and mental health, and the treatment effect of diabetic mellitus erectile ...

    Authors: Huan Feng, Qi Liu, Zhiyao Deng, Hao Li, Huajie Zhang, Jingyu Song, Xiaming Liu, Jihong Liu, Bo Wen and Tao Wang
    Citation: Stem Cell Research & Therapy 2022 13:450
  34. Increasing studies have reported the therapeutic effect of mesenchymal stem cell (MSC)-derived exosomes by which protein and miRNA are clearly characterized. However, the proteomics and miRNA profiles of exoso...

    Authors: Youkun Bi, Xinlong Qiao, Qun Liu, Shaole Song, Keqi Zhu, Xun Qiu, Xiang Zhang, Ce jia, Huiwen Wang, Zhiguang Yang, Ying Zhang and Guangju Ji
    Citation: Stem Cell Research & Therapy 2022 13:449
  35. Adipose-derived stem cells (ADSCs) have provided promising applications for Crohn’s disease (CD). However, the practical efficacy of ADSCs remains controversial, and their mechanism is still unclear. Based on ...

    Authors: Lei Zhang, Chen Ye, Peng Li, Chuanding Li, Weigang Shu, Yujie Zhao and Xiaolei Wang
    Citation: Stem Cell Research & Therapy 2022 13:448
  36. This study tested the hypothesis that overexpression of cellular prion protein in endothelial progenitor cells (PrPcOE-EPCs), defined as “rejuvenated EPCs,” was superior to EPCs for salvaging the critical limb is...

    Authors: Jui-Po Yeh, Pei‐Hsun Sung, John Y. Chiang, Chi-Ruei Huang, Yi-Ling Chen, Jui-Pin Lai and Jiunn-Jye Sheu
    Citation: Stem Cell Research & Therapy 2022 13:447
  37. Bone has important functions in the body. Several researchers have reported that the polysaccharides and lipopolysaccharide derived from microbes can promote osteogenic differentiation of stem cells. Enterococcus...

    Authors: Hyewon Kim, Naeun Oh, Mijin Kwon, Oh-Hee Kwon, Seockmo Ku, Jeongmin Seo and Sangho Roh
    Citation: Stem Cell Research & Therapy 2022 13:446
  38. Tendon is composed of dense fibrous connective tissues, connecting muscle at the myotendinous junction (MTJ) to bone at the enthesis and allowing mechanical force to transmit from muscle to bone. Tendon diseas...

    Authors: Ziming Chen, Peilin Chen, Monica Zheng, Junjie Gao, Delin Liu, Allan Wang, Qiujian Zheng, Toby Leys, Andrew Tai and Minghao Zheng
    Citation: Stem Cell Research & Therapy 2022 13:444
  39. Bone is a rigid organ that provides physical protection and support to vital organs of the body. Bone loss disorders are commonly associated with increased bone marrow adipose tissue. Bone marrow mesenchymal s...

    Authors: Yangge Du, Yunsong Liu, Yongsheng Zhou and Ping Zhang
    Citation: Stem Cell Research & Therapy 2022 13:443
  40. Umbilical cord mesenchymal stem cells (UCMSCs) have great potential in the treatment of spinal cord injury. However, the specific therapeutic effect and optimal transplantation strategy are still unclear. Ther...

    Authors: Yubao Lu, Wei Zhang, Zhenming Tian, Qian Liang, Chenrui Liu, Yingjie Wu, Liangming Zhang and Limin Rong
    Citation: Stem Cell Research & Therapy 2022 13:441
  41. Clinical studies have demonstrated that dental pulp stem cells isolated from permanent teeth (PT-DPSCs) are safe and efficacious for complete pulp regeneration in mature pulpectomized permanent teeth with comp...

    Authors: S. M. Ziauddin, Misako Nakashima, Hideto Watanabe, Michiyo Tominaga and Koichiro Iohara
    Citation: Stem Cell Research & Therapy 2022 13:439
  42. The therapeutic potential of mesenchymal stem cells (MSCs)-derived conditioned media (CM) can be increased after preconditioning with various chemical agents. The aim of this study is comparative evaluation of...

    Authors: Serbay Ozkan, Basak Isildar, Merve Ercin, Selda Gezginci-Oktayoglu, Dildar Konukoglu, Neşet Neşetoğlu, Mahmut Oncul and Meral Koyuturk
    Citation: Stem Cell Research & Therapy 2022 13:438
  43. Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising disease model, even though hiPSC-CMs cultured for extended periods display an undifferentiated transcriptional landscape. M...

    Authors: Juan J. A. M. Muñoz, Rafael Dariolli, Caio Mateus da Silva, Elida A. Neri, Iuri C. Valadão, Lauro Thiago Turaça, Vanessa M. Lima, Mariana Lombardi Peres de Carvalho, Mariliza R. Velho, Eric A. Sobie and Jose E. Krieger
    Citation: Stem Cell Research & Therapy 2022 13:437
  44. Neural stem cells (NSCs)-derived extracellular vesicles (EVs) possess great potential in treating severe neurological and cerebrovascular diseases, as they carry the modulatory and regenerative ingredients of ...

    Authors: Mingzhi Xu, Gang Chen, Yanan Dong, Shensi Xiang, Miaomiao Xue, Yongxue Liu, Haijing Song, Haifeng Song and Yi Wang
    Citation: Stem Cell Research & Therapy 2022 13:436
  45. Although mesenchymal stromal cells (MSCs) from primary tissues have been successfully applied in the clinic, their expansion capabilities are limited and results are variable. MSCs derived from human-induced p...

    Authors: Yolande F. M. Ramos, Tobias Tertel, Georgina Shaw, Simon Staubach, Rodrigo Coutinho de Almeida, Eka Suchiman, Thomas B. Kuipers, Hailiang Mei, Frank Barry, Mary Murphy, Bernd Giebel and Ingrid Meulenbelt
    Citation: Stem Cell Research & Therapy 2022 13:434
  46. Pulmonary fibrosis (PF) is a fatal chronic disease characterized by accumulation of extracellular matrix and thickening of the alveolar wall, ultimately leading to respiratory failure. PF is thought to be init...

    Authors: Roya Rasaei, Apoorvi Tyagi, Shima Rasaei, Seung-Joon Lee, Se-Ran Yang, Kye-Seong Kim, Suresh Ramakrishna and Seok-Ho Hong
    Citation: Stem Cell Research & Therapy 2022 13:433

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