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  1. Hyperactive coagulation might cause dangerous complications such as portal vein thrombosis and pulmonary embolism after mesenchymal stem/stromal cell (MSC) therapy. Tissue factor (TF), an initiator of the extr...

    Authors: Van T. Hoang, Duc Son Le, Duc M. Hoang, Trang Thi Kieu Phan, Lan Anh Thi Ngo, Trung Kien Nguyen, Viet Anh Bui and Liem Nguyen Thanh
    Citation: Stem Cell Research & Therapy 2024 15:56
  2. Neural stem cells (NSCs), especially human NSCs, undergo cellular senescence characterized by an irreversible proliferation arrest and loss of stemness after prolonged culture. While compelling correlative dat...

    Authors: Teng Guan, Ying Guo, Ting Zhou, Qiang Yu, Jingyi Sun, Baoliang Sun, Guohui Zhang and Jiming Kong
    Citation: Stem Cell Research & Therapy 2024 15:55
  3. Unlike in lower vertebrates, Müller glia (MG) in adult mammalian retinas lack the ability to reprogram into neurons after retinal injury or degeneration and exhibit reactive gliosis instead. Whether a transiti...

    Authors: Zhiyuan Yin, Lingling Ge, Zhe Cha, Hui Gao, Luodan A, Yuxiao Zeng, Xiaona Huang, Xuan Cheng, Kai Yao, Zui Tao and Haiwei Xu
    Citation: Stem Cell Research & Therapy 2024 15:54
  4. Authors: Zhenpeng Zhu, Jiayu Yang, Xing Ji, Zicheng Wang, Chengxiang Dai, Suke Li, Xuesong Li, Yajie Xie, Yudong Zheng, Jian Lin and Liqun Zhou
    Citation: Stem Cell Research & Therapy 2024 15:53

    The original article was published in Stem Cell Research & Therapy 2022 13:463

  5. Authors: Rodrigo Azevedo Loiola, Miguel García-Gabilondo, Alba Grayston, Paulina Bugno, Agnieszka Kowalska, Sophie Duban-Deweer, Eleonora Rizzi, Johan Hachani, Yasuteru Sano, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, Maciej Piotr Mazurek, Anna Rosell and Fabien Gosselet
    Citation: Stem Cell Research & Therapy 2024 15:50
  6. Clinically, hormone replacement therapy (HRT) is the main treatment for primary ovarian insufficiency (POI). However, HRT may increase the risk of both breast cancer and cardiovascular disease. Exosomes derive...

    Authors: Fangfang Dai, Hua Liu, Juan He, Jinglin Wu, Chaoyan Yuan, Ruiqi Wang, Mengqin Yuan, Dongyong Yang, Zhimin Deng, Linlin Wang, Yanqing Wang, Xiao Yang, Huiling Wang, Wei Hu and Yanxiang Cheng
    Citation: Stem Cell Research & Therapy 2024 15:49
  7. Allogeneic hepatocyte transplantation is an emerging approach to treat acute liver defects. However, durable engraftment of the transplanted cells remains a daunting task, as they are actively cleared by the r...

    Authors: Nasir Abbas, Kai You, Anteneh Getachew, Feima Wu, Muzammal Hussain, Xinping Huang, Yan Chen, Tingcai Pan and Yinxiong Li
    Citation: Stem Cell Research & Therapy 2024 15:48
  8. Authors: Han Shen, Guanghao Cui, Yanqiong Li, Wenxue Ye, Yimin Sun, Zihan Zhang, Jingjing Li, Guiying Xu, Xiansheng Zeng, Yanxia Zhang, Wencheng Zhang, Zan Huang, Weiqian Chen and Zhenya Shen
    Citation: Stem Cell Research & Therapy 2024 15:47

    The original article was published in Stem Cell Research & Therapy 2019 10:17

  9. Radiotherapy in head and neck cancer management causes degeneration of the salivary glands (SG). This study was designed to determine the potential of gingival mesenchymal stem cells (GMSCs) as a cell-based th...

    Authors: Hagar M. Zayed, Nevine H. Kheir El Din, Ashraf M. Abu-Seida, Asmaa A. Abo Zeid and Ola M. Ezzatt
    Citation: Stem Cell Research & Therapy 2024 15:46
  10. Mesenchymal stem cells (MSCs) are attracting attention as a promising cell-based therapy for the treatment of liver fibrosis or cirrhosis. However, the strategies and potential mechanisms of MSCs therapy need ...

    Authors: Fan Ding, Yuting Liu, Jia Li, Xiao Wei, Jiangdong Zhao, Xiaojing Liu and Liqiang Zhang
    Citation: Stem Cell Research & Therapy 2024 15:44
  11. Ischemia–reperfusion injury to the central nervous system often causes severe complications. The activation of endogenous neural stem cells (NSCs) is considered a promising therapeutic strategy for nerve repai...

    Authors: Shaoqiong Zhang, Kaile Cui, Yuanyuan Li, Yiting Fan, Dongxu Wang, Xingen Yao and Bo Fang
    Citation: Stem Cell Research & Therapy 2024 15:43
  12. Corneal alkali burns can lead to ulceration, perforation, and even corneal blindness due to epithelial defects and extensive cell necrosis, resulting in poor healing outcomes. Previous studies have found that ...

    Authors: Zibo Wang, Changqing Jiang, Yuqiao Fan, Xiaodan Hao, Yanhan Dong, Xinjia He, Jinning Gao, Yongchun Zhang, Meng Li, Mengyuan Wang, Yiming Liu and Wenhua Xu
    Citation: Stem Cell Research & Therapy 2024 15:41
  13. Authors: Armin Attar, Mohsen Farjoud Kouhanjani, Kamran Hessami, Massoud Vosough, Javad Kojuri, Mani Ramzi, Seyed Ali Hosseini, Marjan Faghih and Ahmad Monabati
    Citation: Stem Cell Research & Therapy 2024 15:40

    The original article was published in Stem Cell Research & Therapy 2023 14:264

  14. Authors: Juan M. Ocampo-Godinez, Jose L. Gonzalez-Quiroz, Hector Cote-Palafox, Elizabeth George, Jael A. Vergara-Lope Nuñez, Guillermo Villagomez-Olea, Febe C. Vazquez-Vazquez, Edgar O. Lopez-Villegas, Gloria Leon-Avila, Maria L. Dominguez-Lopez and Marco A. Alvarez-Perez
    Citation: Stem Cell Research & Therapy 2024 15:39

    The original article was published in Stem Cell Research & Therapy 2023 14:312

  15. Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) plays a pivotal role in inducing metabolic inflammation in diabetes. Additionally, the NOD1 ligand disrupts the equilibrium of bone marrow-...

    Authors: Jingwen Qiu, Jing Wu, Wenwen Chen, Yu Ruan, Jingning Mao, Shue Li, Xuan Tang, Lei Zhao, Shengbing Li, Ke Li, Dongfang Liu and Yaqian Duan
    Citation: Stem Cell Research & Therapy 2024 15:38
  16. Adipose-derived stem cells (ASCs) are a critical adult stem cell subpopulation and are widely utilized in the fields of regenerative medicine and stem cell research due to their abundance, ease of harvest, and...

    Authors: Tianyi Sun, Cheng Zhou, Feng Lu, Ziqing Dong, Jianhua Gao and Bin Li
    Citation: Stem Cell Research & Therapy 2024 15:37
  17. Pericytes (PCs) are multipotent contractile cells that wrap around the endothelial cells (ECs) to maintain the blood vessel's functionality and integrity. The hyperglycemia associated with Type 2 diabetes mell...

    Authors: Toka A. Ahmed, Sara M. Ahmed, Hoda Elkhenany, Mohamed A. El-Desouky, Sameh Magdeldin, Aya Osama, Ali Mostafa Anwar, Ihab K. Mohamed, Mohamed Essameldin Abdelgawad, Demiana H. Hanna and Nagwa El-Badri
    Citation: Stem Cell Research & Therapy 2024 15:36
  18. Spinal cord injury (SCI) is a devastating disease that causes extensive damage to oligodendrocytes and neurons leading to demyelination and axonal degeneration. In this study, we co-transplanted cell grafts co...

    Authors: Qian Li, Sumei Liu, Tianqi Zheng, Mo Li, Boling Qi, Liping Zhou, Bochao Liu, Dan Ma, Chao Zhao and Zhiguo Chen
    Citation: Stem Cell Research & Therapy 2024 15:35
  19. Inflammation is a common and important pathological process occurring in any part of the body and relating to a variety of diseases. Effective tissue repair is critical for the survival of impaired organisms. ...

    Authors: Wen Li, Zichao Xiang, Wenjing Yu, Xiaobin Huang, Qian Jiang, Arwa Abumansour, Ying Yang and Chider Chen
    Citation: Stem Cell Research & Therapy 2024 15:34
  20. There is growing evidence that extracellular vesicles (EVs) play a crucial role in the paracrine mechanisms of transplanted human mesenchymal stem cells (hMSCs). Little is known, however, about the influence o...

    Authors: Niyaz Al-Sharabi, Samih Mohamed-Ahmed, Siddharth Shanbhag, Carina Kampleitner, Rammah Elnour, Shuntaro Yamada, Neha Rana, Even Birkeland, Stefan Tangl, Reinhard Gruber and Kamal Mustafa
    Citation: Stem Cell Research & Therapy 2024 15:33
  21. The neuronal transdifferentiation of adult bone marrow cells (BMCs) is still considered an artifact based on an alternative explanation of experimental results supporting this phenomenon obtained over decades....

    Authors: Carlos Bueno, David García-Bernal, Salvador Martínez, Miguel Blanquer and José M. Moraleda
    Citation: Stem Cell Research & Therapy 2024 15:32
  22. Transcription factors HAND1 and HAND2 (HAND1/2) play significant roles in cardiac organogenesis. Abnormal expression and deficiency of HAND1/2 result in severe cardiac defects. However, the function and mechanism...

    Authors: Huixin Guo, Chengwen Hang, Bowen Lin, Zheyi Lin, Hui Xiong, Mingshuai Zhang, Renhong Lu, Junyang Liu, Dan Shi, Duanyang Xie, Yi Liu, Dandan Liang, Jian Yang and Yi-Han Chen
    Citation: Stem Cell Research & Therapy 2024 15:31
  23. Preeclampsia (PE) is a common morbid complication during pregnancy, affecting 2%-8% of pregnancies globally and posing serous risks to the health of both mother and fetus. Currently, the only effective treatme...

    Authors: Haoran Shi, Zejun Yang, Jianjian Cui, Hui Tao, Ruilin Ma and Yin Zhao
    Citation: Stem Cell Research & Therapy 2024 15:30
  24. Spinal cord injuries (SCI) lead to functional alteration with important consequences such as motor and sensory disorders. The repair strategies developed to date remain ineffective. The adipose tissue-derived ...

    Authors: Céline Ertlen, Mostafa Seblani, Maxime Bonnet, Jean-Michel Brezun, Thelma Coyle, Florence Sabatier, Stéphane Fuentes, Patrick Decherchi, Nicolas Serratrice and Tanguy Marqueste
    Citation: Stem Cell Research & Therapy 2024 15:29
  25. Small-scale clinical trials have provided evidence suggesting the effectiveness of stem-cell therapy (SCT) for patients diagnosed with Crohn's disease (CD). The objective of the research was to systematically ...

    Authors: Yunfeng Qiu, Changfeng Li and Shihou Sheng
    Citation: Stem Cell Research & Therapy 2024 15:28
  26. Adipose-derived stromal cells (ADSCs) demonstrate ability to promote tissue healing and down-regulate excessive inflammation. ADSCs have been used to treat critical limb ischemia in preclinical and clinical tr...

    Authors: Ewelina Pilny, Justyna Czapla, Alina Drzyzga, Ryszard Smolarczyk, Sybilla Matuszczak, Magdalena Jarosz-Biej, Łukasz Krakowczyk and Tomasz Cichoń
    Citation: Stem Cell Research & Therapy 2024 15:27
  27. The stem cell characteristic makes basal cells desirable for ex vivo modeling of airway diseases. However, to date, approaches allowing them extensively in vitro serial expansion and maintaining bona fide stem...

    Authors: Meirong Wu, Xiaojing Zhang, Yanjuan Tu, Wenzhao Cheng and Yiming Zeng
    Citation: Stem Cell Research & Therapy 2024 15:26
  28. Autologous fat grafting is hampered by unpredictable graft survival, which is potentially regulated by ferroptosis. Glutathione (GSH), a powerful antioxidant used in tissue preservation, has ferroptosis-regula...

    Authors: Zehua Li, Jinqiang Lu, Zhiqin Dong, Jiaji Liang, Shenghong Li, Wenwen Han, Taixing Cui and Hongwei Liu
    Citation: Stem Cell Research & Therapy 2024 15:25
  29. Elderly patients with acute myeloid leukemia or myelodysplastic syndromes (AML/MDS) have historically had poor prognoses. However, there has been a recent increase in the use of allogenic hematopoietic stem ce...

    Authors: Lu Gao, Li Yang, Shiyuan Zhou, Wenjuan Zhu, Yue Han, Suning Chen, Shengli Xue, Ying Wang, Huiying Qiu, Depei Wu and Xiaojin Wu
    Citation: Stem Cell Research & Therapy 2024 15:24
  30. Over the past decade, there had been progress in the development of cell therapy for insulin-dependent diabetes. Nevertheless, important hurdles that need to be overcome still remain. Protocols for the differe...

    Authors: Mohamed A. Ghoneim, Mahmoud M. Gabr, Sawsan M. El-Halawani and Ayman F. Refaie
    Citation: Stem Cell Research & Therapy 2024 15:23
  31. In recent years, cell therapy has emerged as a new research direction in the treatment of diabetes. However, the underlying molecular mechanisms of mesenchymal stem cell (MSC) differentiation necessary to form...

    Authors: Tianqin Xie, Qiming Huang, Qiulan Huang, Yanting Huang, Shuang Liu, Haixia Zeng and Jianping Liu
    Citation: Stem Cell Research & Therapy 2024 15:22
  32. Regenerative techniques combined with core decompression (CD) are commonly used to treat osteonecrosis of the femoral head (ONFH). However, no consensus exists on regeneration therapy combined with CD that per...

    Authors: Xiaole Wang, Liyou Hu, Bo Wei, Jian Wang, Decai Hou and Xiaolei Deng
    Citation: Stem Cell Research & Therapy 2024 15:21
  33. The glomerulus is a highly complex system, composed of different interdependent cell types that are subjected to various mechanical stimuli. These stimuli regulate multiple cellular functions, and changes in t...

    Authors: Maria Elena Melica, Francesca Cialdai, Gilda La Regina, Chiara Risaliti, Tommaso Dafichi, Anna Julie Peired, Paola Romagnani, Monica Monici and Laura Lasagni
    Citation: Stem Cell Research & Therapy 2024 15:20
  34. After myocardial infarction, the lost myocardium is replaced by fibrotic tissue, eventually progressively leading to myocardial dysfunction. Direct reprogramming of fibroblasts into cardiomyocytes via the forc...

    Authors: Juntao Fang, Qiangbing Yang, Renée G. C. Maas, Michele Buono, Bram Meijlink, Dyonne Lotgerink Bruinenberg, Ernest Diez Benavente, Michal Mokry, Alain van Mil, Li Qian, Marie-José Goumans, Raymond Schiffelers, Zhiyong Lei and Joost P. G. Sluijter
    Citation: Stem Cell Research & Therapy 2024 15:19
  35. Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) offer promising prospects for stimulating cartilage regeneration. The different formation mechanisms suggest that exosomes and ectosom...

    Authors: Tengjing Xu, Xinning Yu, Kaiwang Xu, Yunting Lin, Jiajie Wang, Zongyou Pan, Jinghua Fang, Siheng Wang, Zhuxing Zhou, Hongyun Song, Sunan Zhu and Xuesong Dai
    Citation: Stem Cell Research & Therapy 2024 15:18
  36. Application of pulp regenerative cell therapy for mature teeth with periapical lesions is a critical clinical challenge. The bacterial infection in inaccessible location within the root canal system and in the...

    Authors: Koichiro Iohara, Michiyo Tominaga, Hideto Watanabe and Misako Nakashima
    Citation: Stem Cell Research & Therapy 2024 15:17
  37. Intestinal epithelial cells derived from human pluripotent stem cells (hPSCs) are generally maintained and cultured as organoids in vitro because they do not exhibit adhesion when cultured. However, the three-...

    Authors: JunLong Chen, Shinichiro Horiuchi, So Kuramochi, Tomoyuki Kawasaki, Hayato Kawasumi, Saeko Akiyama, Tomoki Arai, Kenichi Morinaga, Tohru Kimura, Tohru Kiyono, Hidenori Akutsu, Seiichi Ishida and Akihiro Umezawa
    Citation: Stem Cell Research & Therapy 2024 15:16
  38. Although the paracrine effects of mesenchymal stem/stromal cells (MSCs) have been recognized as crucial mediators of their regenerative effects on tissue repair, the potential of MSC secretomes as effective su...

    Authors: Helena Debiazi Zomer, Victor Juan de Souza Lima, Monique Coelho Bion, Karynne Nazare Lins Brito, Michele Rode, Marco Augusto Stimamiglio, Talita da Silva Jeremias and Andrea Gonçalves Trentin
    Citation: Stem Cell Research & Therapy 2024 15:15
  39. Recent studies have shown that umbilical cord mesenchymal stem cells have an anti-aging effect in ovaries, but the cellular and molecular mechanisms of HA-MSC ovarian anti-aging remain to be studied. Therefore...

    Authors: Kai Wang, Xiang Yao, Shu-qian Lin, Xiang-qing Zhu, Xing-hua Pan and Guang-ping Ruan
    Citation: Stem Cell Research & Therapy 2024 15:14
  40. Radiation therapy often leads to late radiation-induced skin fibrosis (RISF), causing movement impairment and discomfort. We conducted a comprehensive study to assess the effectiveness of metformin and adipose...

    Authors: Hamid Malekzadeh, Yusuf Surucu, Somaiah Chinnapaka, Katherine S. Yang, José A. Arellano, Yasamin Samadi, Michael W. Epperly, Joel S. Greenberger, J. Peter Rubin and Asim Ejaz
    Citation: Stem Cell Research & Therapy 2024 15:13
  41. Adipose-derived stem cells (ADSCs) have been extensively used in preclinical and clinical trials for treating various diseases. However, the differences between ADSCs from lean individuals (L-ADSCs) and those ...

    Authors: Bo Wang, Ge Zhang, Yuwen Hu, Ali Mohsin, Zhimin Chen, Weijie Hao, Zhanxia Li, Wei-Qiang Gao, Meijin Guo and Huiming Xu
    Citation: Stem Cell Research & Therapy 2024 15:12
  42. Mesenchymal stem cells in the adult corneal stroma (named corneal stromal stem cells, CSSCs) inhibit corneal inflammation and scarring and restore corneal clarity in pre-clinical corneal injury models. This ce...

    Authors: Mithun Santra, Moira L. Geary, Elizabeth Rubin, Michael Y. S. Hsu, Martha L. Funderburgh, Christine Chandran, Yiqin Du, Deepinder K. Dhaliwal, Vishal Jhanji and Gary Hin-Fai Yam
    Citation: Stem Cell Research & Therapy 2024 15:11
  43. Beyond the observed alterations in cellular structure and mitochondria, the mechanisms linking rare genetic mutations to the development of heart failure in patients affected by desmin mutations remain unclear...

    Authors: Yeranuhi Hovhannisyan, Zhenlin Li, Domitille Callon, Rodolphe Suspène, Vivien Batoumeni, Alexis Canette, Jocelyne Blanc, Hakim Hocini, Cécile Lefebvre, Nora El-Jahrani, Maria Kitsara, Aurore L’honoré, Ekaterini Kordeli, Paul Fornes, Jean-Paul Concordet, Gérard Tachdjian…
    Citation: Stem Cell Research & Therapy 2024 15:10
  44. Acute kidney injury (AKI) has a complex pathophysiology and imposes serious health concerns worldwide. Extracellular vesicles (EVs) derived from induced mesenchymal stem cells (iMSCs) have been recognized as n...

    Authors: Hongduk Kim, Seul Ki Lee, Sungok Hong, Tae Sub Park, Jimin Kim, Soo Kim and Tae Min Kim
    Citation: Stem Cell Research & Therapy 2024 15:9
  45. Diabetes is a disease affecting over 500 million people globally due to insulin insufficiency or insensitivity. For individuals with type 1 diabetes, pancreatic islet transplantation can help regulate their bl...

    Authors: Diepiriye G. Iworima, Robert K. Baker, Cara Ellis, Chris Sherwood, Lisa Zhan, Alireza Rezania, James M. Piret and Timothy J. Kieffer
    Citation: Stem Cell Research & Therapy 2024 15:1

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