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  1. Bone marrow stromal cells (BMSCs) are highly heterogeneous, which may reflect their diverse biological functions, including tissue maintenance, haematopoietic support and immune control. The current understand...

    Authors: Andrew P. Stone, Emma Rand, Gabriel Thornes, Alasdair G. Kay, Amanda L. Barnes, Ian S. Hitchcock and Paul G. Genever
    Citation: Stem Cell Research & Therapy 2024 15:178
  2. Cartilage is a kind of avascular tissue, and it is difficult to repair itself when it is damaged. In this study, we investigated the regulation of chondrogenic differentiation and vascular formation in human j...

    Authors: Hua Liu, Huina Liu, Qiubo Yang and Zhipeng Fan
    Citation: Stem Cell Research & Therapy 2024 15:177
  3. The aim of this study is to systematically review randomized controlled clinical trials (RCTs) studying various types of regenerative medicine methods (such as platelet-rich plasma, stromal vascular fraction, ...

    Authors: Alireza Jafarzadeh, Arash Pour Mohammad, Haniyeh Keramati, Roya Zeinali, Mina Khosravi and Azadeh Goodarzi
    Citation: Stem Cell Research & Therapy 2024 15:176
  4. Endothelial cells (ECs) are widely used as donor cells in tissue engineering, organoid vascularization, and in vitro microvascular model development. ECs are invaluable tools for disease modeling and drug scre...

    Authors: Dan Deng, Yu Zhang, Bo Tang and Zhihui Zhang
    Citation: Stem Cell Research & Therapy 2024 15:175
  5. Chimeric antigen receptor (CAR)-T cell adoptive immunotherapy is a promising cancer treatment that uses genetically engineered T cells to attack tumors. However, this therapy can have some adverse effects. CAR...

    Authors: Farnaz Sani, Shabnam Shojaei, Seyed Amirhossein Tabatabaei, Mohammadhossein Khorraminejad-Shirazi, Mona Latifi, Mahsa Sani and Negar Azarpira
    Citation: Stem Cell Research & Therapy 2024 15:174
  6. Spinal cord injury (SCI) is a disease that causes permanent impairment of motor, sensory, and autonomic nervous system functions. Stem cell transplantation for neuron regeneration is a promising strategic trea...

    Authors: Jang-Woon Kim, Juryun Kim, Soon Min Lee, Yeri Alice Rim, Young Chul Sung, Yoojun Nam, Hyo-Jin Kim, Hyewon Kim, Se In Jung, Jooyoung Lim and Ji Hyeon Ju
    Citation: Stem Cell Research & Therapy 2024 15:173
  7. Development of hematopoietic stem and progenitor cells (HSPC) is a multi-staged complex process that conserved between zebrafish and mammals. Understanding the mechanism underlying HSPC development is a holy g...

    Authors: Min He, Xiaoli Li, Bingxiang Xu, Yinbo Lu, Jingyi Lai, Yiming Ling, Huakai Liu, Ziyang An, Wenqing Zhang and Feifei Li
    Citation: Stem Cell Research & Therapy 2024 15:172
  8. There is a significant demand for intermediate-scale bioreactors in academic and industrial institutions to produce cells for various applications in drug screening and/or cell therapy. However, the applicatio...

    Authors: Mania Ackermann, Fawaz Saleh, Shifaa M. Abdin, Anna Rafiei Hashtchin, Ingrid Gensch, Julia Golgath, Marco Carvalho Oliveira, Ariane H. H. Nguyen, Svenja Gaedcke, Arno Fenske, Mi-Sun Jang, Adan C. Jirmo, Markus Abeln, Gesine Hansen and Nico Lachmann
    Citation: Stem Cell Research & Therapy 2024 15:171
  9. With the development of the economy and the increasing prevalence of skin problems, cutaneous medical aesthetics are gaining more and more attention. Skin disorders like poor wound healing, aging, and pigmenta...

    Authors: Junyi Li, Ye Liu, Rui Zhang, Qianyu Yang, Wei Xiong, Yan He and Qingsong Ye
    Citation: Stem Cell Research & Therapy 2024 15:169
  10. Mechanical stimulation (MS) significantly increases the release of adenine and uracil nucleotides from bone marrow-derived mesenchymal stem cells (BM-MSCs) undergoing osteogenic differentiation. Released nucle...

    Authors: Catarina Bessa-Andrês, Rui Pinto-Cardoso, Karyna Tarasova, Ana Luísa Pereira-Gonçalves, Joana Maria Gaio-Ferreira-Castro, Liliana S. Carvalho, Maria Adelina Costa, Fátima Ferreirinha, Ana Canadas-Sousa, José Marinhas, Rolando Freitas, Rui Lemos, Adélio Vilaça, António Oliveira, Paulo Correia-de-Sá and José Bernardo Noronha-Matos
    Citation: Stem Cell Research & Therapy 2024 15:168
  11. Stem cell therapy is a promising alternative for inflammatory diseases and tissue injury treatment. Exogenous delivery of mesenchymal stem cells is associated with instant blood-mediated inflammatory reactions...

    Authors: Shobha Regmi, Shiva Pathak, Dinesh Chaudhary, Jong Oh Kim, Joo-Won Nam, Hyung-Sik Kim, Hu-Lin Jiang, Dongryeol Ryu, Jong-Hyuk Sung, Simmyung Yook and Jee-Heon Jeong
    Citation: Stem Cell Research & Therapy 2024 15:167
  12. Hypertrophic scarring results from myofibroblast differentiation and persistence during wound healing. Currently no effective treatment for hypertrophic scarring exists however, autologous fat grafting has bee...

    Authors: S. Higginbotham, V. L. Workman, A-V. Giblin, N. H. Green, D. W. Lambert and V. Hearnden
    Citation: Stem Cell Research & Therapy 2024 15:166
  13. Mesenchymal stem cells (MSCs) have emerged as living biodrugs for myocardial repair and regeneration. Recent randomized controlled trials (RCTs) have reported that MSC-based therapy is safe and effective in he...

    Authors: Ziyad T. Ahmed, Maha Saad Zain Al-Abeden, Mohamed Ghaith Al Abdin, Mohamad Ayham Muqresh, Ghazi I. Al Jowf, Lars M. T. Eijssen and Khawaja Husnain Haider
    Citation: Stem Cell Research & Therapy 2024 15:165
  14. Transplantation of CD34+ hematopoietic stem and progenitor cells (HSPC) into immunodeficient mice is an established method to generate humanized mice harbouring a human immune system. Different sources and method...

    Authors: Teja Celhar, Xinyi Li, Yunqian Zhao, Hui Chien Tay, Andrea Lee, Hui Hua Liew, Edwin Kunxiang Shepherdson, Ravisankar Rajarethinam, Yiping Fan, Anselm Mak, Jerry Kok Yen Chan, Amit Singhal and Takeshi Takahashi
    Citation: Stem Cell Research & Therapy 2024 15:164
  15. A rising population faces challenges with healing-impaired cutaneous wounds, often leading to physical disabilities. Adipose-derived stem cells (ASCs), specifically in the cell sheet format, have emerged as a ...

    Authors: Yueh-Chen Chen, Er-Yuan Chuang, Yuan-Kun Tu, Chia-Lang Hsu and Nai-Chen Cheng
    Citation: Stem Cell Research & Therapy 2024 15:163
  16. Autologous mesenchymal stem cells (MSCs) have emerged as a therapeutic option for many diseases. Hypertensive kidney disease (HKD) might impair MSCs’ reparative ability by altering the biomolecular properties,...

    Authors: Gurparneet Kaur Sohi, Naba Farooqui, Arjunmohan Mohan, Kamalnath Sankaran Rajagopalan, Li Xing, Xiang Y. Zhu, Kyra Jordan, James D. Krier, Ishran M. Saadiq, Hui Tang, LaTonya J. Hickson, Alfonso Eirin, Lilach O. Lerman and Sandra M. Herrmann
    Citation: Stem Cell Research & Therapy 2024 15:162
  17. Mesenchymal stem cell treatment (MST) has emerged as a new therapeutic strategy for Crohn’s perianal fistulas. It has been demonstrated that a fibrotic tract on MRI with a MAGNIFI-CD score ≤ 6 is the best pred...

    Authors: A. J. M. Pronk, K. J. Beek, M.E. Wildenberg, W. A. Bemelman, J. Stoker and C. J. Buskens
    Citation: Stem Cell Research & Therapy 2024 15:161
  18. Metabolic syndrome (MetS) is a significant epidemiological problem worldwide. It is a pre-morbid, chronic and low-grade inflammatory disorder that precedes many chronic diseases. Wharton’s jelly-derived mesenc...

    Authors: Alvin Man Lung Chan, Angela Min Hwei Ng, Mohd Heikal Mohd Yunus, Ruszymah Hj Idrus, Jia Xian Law, Muhammad Dain Yazid, Kok-Yong Chin, Mohd Rafizul Mohd Yusof, See Nguan Ng, Benson Koh and Yogeswaran Lokanathan
    Citation: Stem Cell Research & Therapy 2024 15:160
  19. Intra-articular injection of adipose-derived mesenchymal stromal cells (ASCs) and/or platelet-rich plasma (PRP) have been reported to independently and synergistically improve healing of osteochondral lesions ...

    Authors: Tomoya Iseki, Benjamin B. Rothrauff, Shinsuke Kihara, Kalon J. Overholt, Tarek Taha, Hang Lin, Peter G. Alexander and Rocky S. Tuan
    Citation: Stem Cell Research & Therapy 2024 15:159
  20. Nerve guide conduits are a promising strategy for reconstructing peripheral nerve defects. Improving the survival rate of seed cells in nerve conduits is still a challenge and microcarriers are an excellent th...

    Authors: Yaqiong Zhu, Dan Yi, Jing Wang, Yongyi Zhang, Molin Li, Jun Ma, Yongjiao Ji, Jiang Peng, Yuexiang Wang and Yukun Luo
    Citation: Stem Cell Research & Therapy 2024 15:158
  21. Mitochondrial transplantation and transfer are being explored as therapeutic options in acute and chronic diseases to restore cellular function in injured tissues. To limit potential immune responses and rejec...

    Authors: David F. Bodenstein, Gabriel Siebiger, Yimu Zhao, Aaron J. Clasky, Avinash N. Mukkala, Erika L. Beroncal, Lauren Banh, Lili Aslostovar, Sonya Brijbassi, Sarah E. Hogan, James D. McCully, Mohadeseh Mehrabian, Thomas H. Petersen, Lisa A. Robinson, Melanie Walker, Constantine Zachos…
    Citation: Stem Cell Research & Therapy 2024 15:157
  22. Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into cells of different lineages to form mesenchymal tissues, which are promising in regard to treatment for bone diseases. Their oste...

    Authors: Erfan Wei, Menglong Hu, Likun Wu, Xingtong Pan, Qiyue Zhu, Hao Liu and Yunsong Liu
    Citation: Stem Cell Research & Therapy 2024 15:156
  23. In the past decade, intestinal organoid technology has paved the way for reproducing tissue or organ morphogenesis during intestinal physiological processes in vitro and studying the pathogenesis of various in...

    Authors: Tao Xiang, Jie Wang and Hui Li
    Citation: Stem Cell Research & Therapy 2024 15:155
  24. Mesenchymal stromal cells (MSCs) isolated from the periodontal ligament (hPDL-MSCs) have a high therapeutic potential, presumably due to their immunomodulatory properties. The interaction between hPDL-MSCs and...

    Authors: Christian Behm, Oliwia Miłek, Xiaohui Rausch-Fan, Andreas Moritz and Oleh Andrukhov
    Citation: Stem Cell Research & Therapy 2024 15:154
  25. The therapeutic status of allogeneic stem cell transplantation (allo-SCT) as a post-remission treatment for patients with high-risk acute myeloid leukemia (AML) was well-accepted. However, the optimal treatmen...

    Authors: Wu Ye, Xia Wu, Ruying Zhao, Xuelian Jin, Hui Li, Ying Qu, Jie Ji and Zhigang Liu
    Citation: Stem Cell Research & Therapy 2024 15:153
  26. X-linked juvenile retinoschisis (XLRS) is an inherited disease caused by RS1 gene mutation, which leads to retinal splitting and visual impairment. The mechanism of RS1-associated retinal degeneration is not full...

    Authors: Chunwen Duan, Chengcheng Ding, Xihao Sun, Shengru Mao, Yuqin Liang, Xinyu Liu, Xiaoyan Ding, Jiansu Chen and Shibo Tang
    Citation: Stem Cell Research & Therapy 2024 15:152
  27. Mesenchymal stem cell-neural progenitors (MSC-NPs) are a bone marrow mesenchymal stem cell (MSC)-derived ex vivo manipulated cell product with therapeutic potential in multiple sclerosis (MS). The objective of...

    Authors: Violaine K. Harris, James Stark, Armistead Williams, Morgan Roche, Michaela Malin, Anjali Kumar, Alyssa L. Carlson, Cara Kizilbash, Jaina Wollowitz, Caroline Andy, Linda M. Gerber and Saud A. Sadiq
    Citation: Stem Cell Research & Therapy 2024 15:151
  28. Mesenchymal stem/stromal cells (MSCs) are not only capable of self-renewal, trans-differentiation, homing to damaged tissue sites and immunomodulation by secretion of trophic factors but are also easy to isola...

    Authors: Sina Christoffers, Lisa Seiler, Elena Wiebe and Cornelia Blume
    Citation: Stem Cell Research & Therapy 2024 15:150
  29. Autoimmune uveitis is an inflammatory disease triggered by an aberrant immune response. Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) are emerging as potential therapeutic agents for th...

    Authors: Yanan Duan, Xiteng Chen, Hui Shao, Yongtao Li, Zhihui Zhang, Huan Li, Chuan Zhao, Hong Xiao, Jiawei Wang and Xiaomin Zhang
    Citation: Stem Cell Research & Therapy 2024 15:149
  30. Mesenchymal stem cells (MSCs) are known as one of the best candidate cells to produce cardiac pacemaker-like cells (CPLCs). Upregulation of TBX3 transcription factor and inhibition of the nodal signal pathway ...

    Authors: Faris Basalamah, Ismail Hadisoebroto Dilogo, Sunu Budhi Raharjo, Muchtaruddin Mansyur, Nuryati Chairani Siregar, Nurhadi Ibrahim, Budi Yuli Setianto and Yoga Yuniadi
    Citation: Stem Cell Research & Therapy 2024 15:148
  31. Bleomycin (BLM)-induced lung injury is characterized by mixed histopathologic changes with inflammation and fibrosis, such as observed in human patients with bronchopulmonary dysplasia, idiopathic pulmonary fi...

    Authors: Kaung Htet Nay Win, Yoshihiro Kushida, Keiji Yamana, Sota Iwatani, Makiko Yoshida, Nanako Nino, Cho Yee Mon, Hiroyuki Ohsaki, Shingo Kamoshida, Kazumichi Fujioka, Mari Dezawa and Noriyuki Nishimura
    Citation: Stem Cell Research & Therapy 2024 15:147
  32. Based on previous in vivo studies and human trials, intrathecal cell delivery is a safe and relevant therapeutic tool for improving patient's quality of life with neurological conditions. We aimed to character...

    Authors: Luz Estella Mesa Bedoya, Jhyld Carolaind Camacho Barbosa, Lucas López Quiceno, Freddy Barrios Arroyave, Karolynn Halpert, Julián Andrés España Peña and Juan Carlos Salazar Uribe
    Citation: Stem Cell Research & Therapy 2024 15:146
  33. Mesenchymal stem cells (MSCs) play important roles in tissue homeostasis by providing a supportive microenvironmental niche for the hematopoietic system. Cigarette smoking induces systemic abnormalities, inclu...

    Authors: Hyun Sung Park, Byung-Chul Lee, Dong-Hoon Chae, Aaron Yu, Jae Han Park, Jiyoung Heo, Myoung Hee Han, Keonwoo Cho, Joong Won Lee, Ji-Won Jung, Cynthia E. Dunbar, Mi-Kyung Oh and Kyung-Rok Yu
    Citation: Stem Cell Research & Therapy 2024 15:145
  34. The aim of this study was to evaluate potential synergistic effects of a single, local application of human umbilical cord MSC-derived sEVs in combination with a low dose of recombinant human rhBMP-2 to promot...

    Authors: Amelie Deluca, Andrea Wagner, Patrick Heimel, Christian Deininger, Florian Wichlas, Heinz Redl, Eva Rohde, Herbert Tempfer, Mario Gimona and Andreas Traweger
    Citation: Stem Cell Research & Therapy 2024 15:144
  35. Spinal cord injury (SCI) is a debilitating illness in humans that causes permanent loss of movement or sensation. To treat SCI, exosomes, with their unique benefits, can circumvent limitations through direct s...

    Authors: Raju Poongodi, Tao-Hsiang Yang, Ya-Hsien Huang, Kuender D. Yang, Hong-Zhao Chen, Tsuei-Yu Chu, Tao-Yeuan Wang, Hsin-Chieh Lin and Jen-Kun Cheng
    Citation: Stem Cell Research & Therapy 2024 15:143
  36. Researchers have attempted to generate transfusable oxygen carriers to mitigate RBC supply shortages. In vitro generation of RBCs using stem cells such as hematopoietic stem and progenitor cells (HSPCs), embry...

    Authors: Hyeonwoo Ju, Yeowon Sohn, Yoojun Nam and Yeri Alice Rim
    Citation: Stem Cell Research & Therapy 2024 15:142
  37. Previous studies have suggested that macrophages are present during lens regeneration in newts, but their role in the process is yet to be elucidated.

    Authors: Georgios Tsissios, Anthony Sallese, J. Raul Perez-Estrada, Jared A. Tangeman, Weihao Chen, Byran Smucker, Sophia C. Ratvasky, Erika Grajales-Esquivel, Arielle Martinez, Kimberly J. Visser, Alberto Joven Araus, Hui Wang, András Simon, Maximina H. Yun and Katia Del Rio-Tsonis
    Citation: Stem Cell Research & Therapy 2024 15:141
  38. Perianal fistulas (PF) affect one-third patients with Crohn’s disease (CD) with limited therapeutic options. There is dearth of literature on safety and efficacy of bone marrow-derived mesenchymal stromal cell...

    Authors: Shekhar Swaroop, Sudheer Kumar Vuyyuru, Bhaskar Kante, Peeyush Kumar, Sandeep Kumar Mundhra, Umang Arora, Ankur Goyal, Devasenathipathy Kandasamy, Raju Sharma, Kavirajan Kabilan, Saurabh Kedia, Nihar Ranjan Dash and Vineet Ahuja
    Citation: Stem Cell Research & Therapy 2024 15:140
  39. The concept of “stemness” incorporates the molecular mechanisms that regulate the unlimited self-regenerative potential typical of undifferentiated primitive cells. These cells possess the unique ability to na...

    Authors: Domenico Aprile, Deanira Patrone, Gianfranco Peluso and Umberto Galderisi
    Citation: Stem Cell Research & Therapy 2024 15:139
  40. Clinical trials have provided evidence that transplants of dopaminergic precursors, which may be replaced by new in vitro stem cell sources, can integrate into the host tissue, and alleviate motor symptoms in ...

    Authors: Ana I. Rodríguez-Pérez, Pablo Garrido-Gil, Maria García-Garrote, Ana Muñoz, Juan A. Parga, Jose Luis Labandeira-García and Jannette Rodríguez-Pallares
    Citation: Stem Cell Research & Therapy 2024 15:138
  41. Scar tissue is the inevitable result of repairing human skin after it has been subjected to external destructive stimuli. It leads to localized damage to the appearance of the skin, accompanied by symptoms suc...

    Authors: Menglin Wang, Jianyu Zhao, Jiacheng Li, Meng Meng and Mengru Zhu
    Citation: Stem Cell Research & Therapy 2024 15:137
  42. Alzheimer’s disease (AD) is a prevalent form of dementia leading to memory loss, reduced cognitive and linguistic abilities, and decreased self-care. Current AD treatments aim to relieve symptoms and slow dise...

    Authors: Zimeng Cao, Fanshu Kong, Jiaqi Ding, Chunxia Chen, Fumei He and Wenbin Deng
    Citation: Stem Cell Research & Therapy 2024 15:136
  43. Biomaterials used in bone tissue engineering must fulfill the requirements of osteoconduction, osteoinduction, and osseointegration. However, biomaterials with good osteoconductive properties face several chal...

    Authors: Bingqian Wang, Xinfang Xie, Wenbin Jiang, Yichen Zhan, Yifan Zhang, Yaqi Guo, Zhenxing Wang, Nengqiang Guo, Ke Guo and Jiaming Sun
    Citation: Stem Cell Research & Therapy 2024 15:135
  44. Hypoxic-Ischemic Encephalopathy (HIE) is a leading cause of mortality and morbidity in newborns. Recent research has shown promise in using intranasal mesenchymal stem cell (MSC) therapy if administered within...

    Authors: Eva C. Hermans, Vanessa Donega, Cobi J. Heijnen, Caroline G.M. de Theije and Cora H. Nijboer
    Citation: Stem Cell Research & Therapy 2024 15:134
  45. Human hematopoietic organoids have a wide application value for modeling human bone marrow diseases, such as acute hematopoietic radiation injury. However, the manufacturing of human hematopoietic organoids is...

    Authors: Keyi Chen, Yunqiao Li, Xumin Wu, Xuan Tang, Bowen Zhang, Tao Fan, Lijuan He, Xuetao Pei and Yanhua Li
    Citation: Stem Cell Research & Therapy 2024 15:133
  46. Induced pluripotent stem cells (iPSCs)-derived kidney organoids are a promising model for studying disease mechanisms and renal development. Despite several protocols having been developed, further improvement...

    Authors: Ekaterina Pecksen, Sergey Tkachuk, Cristoph Schröder, Marc Vives Enrich, Anindita Neog, Cory P. Johnson, Niko Lachmann, Hermann Haller and Yulia Kiyan
    Citation: Stem Cell Research & Therapy 2024 15:132
  47. Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) hold great therapeutic potential in regenerative medicine. Therefore, it is crucial to establish a Good Manufacturing Practice (GMP)-compliant methodolo...

    Authors: Wanglong Chu, Fen Zhang, Xiuping Zeng, Fangtao He, Guanyan Shang, Tao Guo, Qingfang Wang, Jianfu Wu, Tongjing Li, Zhen Zhong Zhong, Xiao Liang, Junyuan Hu and Muyun Liu
    Citation: Stem Cell Research & Therapy 2024 15:131
  48. Hyaluronan (HA) is an extracellular glycosaminoglycan polysaccharide with widespread roles throughout development and in healthy and neoplastic tissues. In pluripotent stem cell culture it can support both ste...

    Authors: Paul A. De Sousa, Leo Perfect, Jinpei Ye, Kay Samuels, Ewa Piotrowska, Martin Gordon, Ryan Mate, Elsa Abranches, Thomas M. Wishart, David H. Dockrell and Aidan Courtney
    Citation: Stem Cell Research & Therapy 2024 15:130
  49. Human bone marrow-derived stem cells (hBMDSCs) are well characterized mediators of tissue repair and regeneration. An increasing body of evidence indicates that these cells exert their therapeutic effects larg...

    Authors: Giulia Bonavina, Ramanaiah Mamillapalli, Graciela Krikun, Yuping Zhou, Nimisha Gawde and Hugh S. Taylor
    Citation: Stem Cell Research & Therapy 2024 15:129

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