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  1. Content type: Review

    Synovial-derived cells, found in the synovial membrane of human joints, were obtained by digestion of the synovial membrane and were subsequently expanded in vitro. The identity of synovial-derived cells has l...

    Authors: Fangqi Li, Yiyong Tang, Bin Song, Menglei Yu, Qingyue Li, Congda Zhang, Jingyi Hou and Rui Yang

    Citation: Stem Cell Research & Therapy 2019 10:260

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  2. Content type: Research

    Mesenchymal stem cells (MSCs) have emerged as a promising therapy for type 2 diabetes (T2D). Mechanistic researches demonstrate that the anti-diabetic effect of MSCs is partially mediated by eliciting macropha...

    Authors: Jieqing Gao, Yu Cheng, Haojie Hao, Yaqi Yin, Jing Xue, Qi Zhang, Lin Li, Jiejie Liu, Zongyan Xie, Songyan Yu, Bing Li, Weidong Han and Yiming Mu

    Citation: Stem Cell Research & Therapy 2019 10:259

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  3. Content type: Research

    Liver organoid technology holds great promises to be used in large-scale population-based drug screening and in future regenerative medicine strategies. Recently, some studies reported robust protocols for gen...

    Authors: Ernesto Goulart, Luiz Carlos de Caires-Junior, Kayque Alves Telles-Silva, Bruno Henrique Silva Araujo, Gerson S. Kobayashi, Camila Manso Musso, Amanda Faria Assoni, Danyllo Oliveira, Elia Caldini, Jonathan A. Gerstenhaber, Silvano Raia, Peter I. Lelkes and Mayana Zatz

    Citation: Stem Cell Research & Therapy 2019 10:258

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  5. Content type: Short report

    Human adipose-derived stromal cells (hASCs) have been gaining increasing popularity in regenerative medicine thanks to their multipotency, ease of collection, and efficient culture. Similarly to other stromal ...

    Authors: Mirasbek Kuterbekov, Paul Machillot, Francis Baillet, Alain M. Jonas, Karine Glinel and Catherine Picart

    Citation: Stem Cell Research & Therapy 2019 10:256

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  6. Content type: Research

    Obesity impairs a variety of cell types including adipose-derived mesenchymal stem cells (ASCs). ASCs are indispensable for tissue homeostasis/repair, immunomodulation, and cell renewal. It has been demonstrat...

    Authors: Andreas Ritter, Nina-Naomi Kreis, Susanne Roth, Alexandra Friemel, Lukas Jennewein, Christine Eichbaum, Christine Solbach, Frank Louwen and Juping Yuan

    Citation: Stem Cell Research & Therapy 2019 10:255

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  7. Content type: Research

    Stem cell-based bone tissue engineering shows promise for bone repair but faces some challenges, such as insufficient osteogenesis and limited architecture flexibility of the cell-delivery scaffold.

    Authors: Hang Lin, Ying Tang, Thomas P. Lozito, Nicholas Oyster, Bing Wang and Rocky S. Tuan

    Citation: Stem Cell Research & Therapy 2019 10:254

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  8. Content type: Research

    For adipose-derived stromal cells (ASCs) to be safe for use in the clinical setting, they need to be prepared using good manufacturing practices (GMPs). Fetal bovine serum (FBS), used to expand ASCs in vitro i...

    Authors: Carla Dessels, Melvin A. Ambele and Michael S. Pepper

    Citation: Stem Cell Research & Therapy 2019 10:253

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  9. Content type: Research

    Taking advantage of cellular paracrine mechanisms, the secretome of adipose-derived stem cells (ADSCs) and adipose tissue has been demonstrated to induce tissue repair and regeneration in various ischemic and ...

    Authors: Yunfan He, Jing Xia, Hsinkai Chen, Liangyue Wang, Chengliang Deng and Feng Lu

    Citation: Stem Cell Research & Therapy 2019 10:252

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  10. Content type: Research

    Autosomal dominant osteopetrosis type II (ADO2) is a rare human genetic disease that has been broadly studied as an important osteopetrosis model; however, there are no disease-specific induced pluripotent ste...

    Authors: Minglin Ou, Chunhong Li, Donge Tang, Wen Xue, Yong Xu, Peng Zhu, Bo Li, Jiansheng Xie, Jiejing Chen, Weiguo Sui, Lianghong Yin and Yong Dai

    Citation: Stem Cell Research & Therapy 2019 10:251

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  11. Content type: Research

    Premature ovarian insufficiency (POI) is one of the leading causes of female infertility, which is caused by an abnormal ovarian reserve. Currently, there is no effective treatment to restore the fertility of ...

    Authors: Ziling Yang, Xin Du, Cunli Wang, Jin Zhang, Conghui Liu, Yu Li and Hong Jiang

    Citation: Stem Cell Research & Therapy 2019 10:250

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  12. Content type: Research

    The generation of functional human epidermal melanocytes (HEM) from stem cells provides an unprecedented source for cell-based therapy in vitiligo. Despite the important efforts exerted to obtain melanin-produ...

    Authors: Gabriela Zavala, Carolina Sandoval, Daniel Meza, Rafael Contreras, Walter Gubelin and Maroun Khoury

    Citation: Stem Cell Research & Therapy 2019 10:249

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  13. Content type: Research

    Mesenchymal stem/stromal cells (MSCs) are considered an important candidate in cell therapy and tissue engineering approaches. The culture of stem cells in a 3D environment is known to better resemble the in v...

    Authors: Dominik Egger, Ana Catarina Oliveira, Barbara Mallinger, Hatim Hemeda, Verena Charwat and Cornelia Kasper

    Citation: Stem Cell Research & Therapy 2019 10:248

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  14. Content type: Research

    Increasing evidence has shown that mesenchymal stem cells (MSCs) yield a favorable therapeutic benefit for thermal burn skin wounds. Human amniotic MSCs (hAMSCs) derived from amniotic membrane have multilineag...

    Authors: Jing-Yuan Li, Kang-Kang Ren, Wen-Jie Zhang, Ling Xiao, Han-You Wu, Qian-Yu Liu, Ting Ding, Xiang-Cheng Zhang, Wen-Jia Nie, Yu Ke, Ke-Yu Deng, Quan-Wen Liu and Hong-Bo Xin

    Citation: Stem Cell Research & Therapy 2019 10:247

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  15. Content type: Research

    Graves’ ophthalmopathy (GO) is a complication of Graves’ disease (GD), in which orbital connective tissues become inflamed and increase in volume and orbital fibroblasts within the orbital fat and extraocular ...

    Authors: Mira Park, J. Paul Banga, Gi Jin Kim, MinYoung Kim and Helen Lew

    Citation: Stem Cell Research & Therapy 2019 10:246

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  16. Content type: Research

    Trophoblasts as a specific cell lineage are crucial for the correct function of the placenta. Human trophoblast stem cells (hTSCs) are a proliferative population that can differentiate into syncytiotrophoblast...

    Authors: Zhuosi Li, Osamu Kurosawa and Hiroo Iwata

    Citation: Stem Cell Research & Therapy 2019 10:245

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  17. Content type: Research

    Tissue regeneration disorder after endometrial injury is an important cause of intrauterine adhesions, amenorrhea, and infertility in women. Both bone marrow mesenchymal stem cell (BMSC) transplantation and el...

    Authors: Liangjun Xia, Qingyu Meng, Jin Xi, Qin Han, Jie Cheng, Jie Shen, Youbing Xia and Liyun Shi

    Citation: Stem Cell Research & Therapy 2019 10:244

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  18. Content type: Research

    The balance of oral microbiomes is crucial to maintain oral health. Microecological imbalance can impair the function of mesenchymal stem cells (MSCs) and lead to delay wound healing. Probiotics is a promising...

    Authors: Nannan Han, Lu Jia, Yingying Su, Juan Du, Lijia Guo, Zhenhua Luo and Yi Liu

    Citation: Stem Cell Research & Therapy 2019 10:243

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  19. Content type: Review

    Exosomes are extracellular membranous nanovesicles that mediate local and systemic intercellular communication by transporting proteins or nucleic acids (DNA and RNA) into target cells, thus altering the behav...

    Authors: Pengyu Hong, Hao Yang, Yue Wu, Kun Li and Zhangui Tang

    Citation: Stem Cell Research & Therapy 2019 10:242

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  20. Content type: Commentary

    When studying purified hematopoietic stem cells, the urge for mechanisms and reductionist approaches appears to be overwhelming. The prime focus of the field has recently been on the study of highly purified h...

    Authors: Peter Quesenberry, Theo Borgovan, Chibuikem Nwizu, Mark Dooner and Laura Goldberg

    Citation: Stem Cell Research & Therapy 2019 10:241

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  21. Content type: Research

    Adipose-derived mesenchymal stem cells (ADMSC) are non-haematopoietic, fibroblast-like multipotent progenitor cells. They have the potential for trilineage (adipocyte, chondrocyte and osteocyte) differentiatio...

    Authors: Luise Doering, Rahul Khatri, Sebastian Friedrich Petry, Heinrich Sauer, Hans-Peter Howaldt and Thomas Linn

    Citation: Stem Cell Research & Therapy 2019 10:240

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  22. Content type: Research

    Type 1 diabetes (T1D) is an autoimmune disease resulting from the destruction of insulin-secreting islet β cells by autoreactive T cells. Non-obese diabetic (NOD) mice are the widely used animal model for huma...

    Authors: Min Su, Yujun Lin, Zhixu He and Laijun Lai

    Citation: Stem Cell Research & Therapy 2019 10:239

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  24. Content type: Research

    Hepatocellular carcinoma (HCC) is one of the most common tumors globally, with varying prevalence based on endemic risk factors. Bone morphogenetic protein (BMP) exhibits a broad spectrum of biological activit...

    Authors: Peng-Cheng Feng, Xing-Fei Ke, Hui-Lan Kuang, Li-Li Pan, Qiang Ye and Jian-Bing Wu

    Citation: Stem Cell Research & Therapy 2019 10:237

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  25. Content type: Research

    The differentiation of corneal limbal stem cells (LSCs) from human pluripotent stem cells (hPSCs) has great power as a novel treatment for ocular surface reconstruction and for modeling corneal epithelial rene...

    Authors: Meri Vattulainen, Tanja Ilmarinen, Laura Koivusalo, Keijo Viiri, Heidi Hongisto and Heli Skottman

    Citation: Stem Cell Research & Therapy 2019 10:236

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  26. Content type: Research

    Adipose tissue-derived mesenchymal stromal cells (ASCs) have been shown to exhibit some promising properties of their use in regenerative medicine as advanced therapy medicinal products (ATMP). However, differ...

    Authors: Justyna Czapla, Sybilla Matuszczak, Klaudia Kulik, Ewa Wiśniewska, Ewelina Pilny, Magdalena Jarosz-Biej, Ryszard Smolarczyk, Tomasz Sirek, Michał Oskar Zembala, Marian Zembala, Stanisław Szala and Tomasz Cichoń

    Citation: Stem Cell Research & Therapy 2019 10:235

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  27. Content type: Research

    Neurovascular unit restoration is crucial for nerve regeneration, especially in critical gaps of injured peripheral nerve. Multipotent vascular stem cells (MVSCs) harvested from an adult blood vessel are invol...

    Authors: Ching-Wen Huang, Yuan-Yu Hsueh, Wen-Chin Huang, Shyam Patel and Song Li

    Citation: Stem Cell Research & Therapy 2019 10:234

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  28. Content type: Research

    Cancer stem cells always express high levels of stemness-associated transcription factors to maintain their features. However, the regulatory mechanism of the stemness of cancer stem cells mediated by transcri...

    Authors: Fan Yang, Pei Cui, Yu Lu and Xiaobo Zhang

    Citation: Stem Cell Research & Therapy 2019 10:233

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  29. Content type: Research

    Mesenchymal stem cells (MSCs) are multipotent cells with broad immunosuppressive capacities. Recently, it has been reported that MSCs can transfer mitochondria to various cell types, including fibroblast, canc...

    Authors: Patricia Luz-Crawford, Javier Hernandez, Farida Djouad, Noymar Luque-Campos, Andres Caicedo, Séverine Carrère-Kremer, Jean-Marc Brondello, Marie-Luce Vignais, Jérôme Pène and Christian Jorgensen

    Citation: Stem Cell Research & Therapy 2019 10:232

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  30. Content type: Research

    Sepsis remains a source of high mortality in hospitalized patients despite proper antibiotic approaches. Encouragingly, mesenchymal stromal cells (MSCs) and their produced extracellular vesicles (EVs) have bee...

    Authors: Kyong-Su Park, Kristina Svennerholm, Ganesh V. Shelke, Elga Bandeira, Cecilia Lässer, Su Chul Jang, Rakesh Chandode, Inta Gribonika and Jan Lötvall

    Citation: Stem Cell Research & Therapy 2019 10:231

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  31. Content type: Review

    The skin has important barrier, sensory, and immune functions, contributing to the health and integrity of the organism. Extensive skin injuries that threaten the entire organism require immediate and effectiv...

    Authors: Ronghua Yang, Fengxia Liu, Jingru Wang, Xiaodong Chen, Julin Xie and Kun Xiong

    Citation: Stem Cell Research & Therapy 2019 10:229

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  32. Content type: Research

    Human-induced pluripotent stem cells (hiPSCs) show a great promise as a renewable source of cells with broad biomedical applications. Since insulin has been used in the maintenance of hiPSCs, in this study we ...

    Authors: Mohammad Shahbazi, Paige Cundiff, Wenyu Zhou, Philip Lee, Achchhe Patel, Sunita L. D’Souza, Fahim Abbasi, Thomas Quertermous and Joshua W. Knowles

    Citation: Stem Cell Research & Therapy 2019 10:228

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  33. Content type: Research

    High temperature has a very adverse effect on mammalian spermatogenesis and eventually leads to sub- or infertility through either apoptosis or DNA damage. However, the direct effects of heat stress on the dev...

    Authors: Jia Wang, Wei-Jun Gao, Shou-Long Deng, Xiang Liu, Hua Jia and Wen-Zhi Ma

    Citation: Stem Cell Research & Therapy 2019 10:227

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  34. Content type: Research

    MicroRNAs (miRNAs) play a key role in regulating cell differentiation. In the present study, we aimed to explore the role of miR-140-5p in odontoblastic differentiation of dental pulp stem cells (DPSCs).

    Authors: Xiaohui Lu, Xi Chen, Jing Xing, Min Lian, Dan Huang, Yuanzhou Lu, Guijuan Feng and Xingmei Feng

    Citation: Stem Cell Research & Therapy 2019 10:226

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  35. Content type: Research

    Intrauterine adhesion (IUA) is one of the most serious complications in patients with endometrial repair disorder after injury. Currently, there is no effective treatment for IUA. Stem cell is the main candida...

    Authors: Yuan Yao, Ran Chen, Guowu Wang, Yu Zhang and Fang Liu

    Citation: Stem Cell Research & Therapy 2019 10:225

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  36. Content type: Research

    Interferon-β (IFN-β) is a cytokine with pleiotropic cellular functions, including antiviral, antiproliferative, and immunomodulatory activities. IFN-β inhibits multiple tumor cell growth in vitro. However, the...

    Authors: Lingqian Du, Qianyu Liang, Shaohua Ge, Chengzhe Yang and Pishan Yang

    Citation: Stem Cell Research & Therapy 2019 10:224

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  37. Content type: Research

    The diabetic foot ulcer (DFU) is one of the most prevalent complications of diabetes mellitus and often develops severe effects that can lead to amputation. A non-healing “minor” amputation often precedes a ma...

    Authors: Roberto Lonardi, Nicola Leone, Stefano Gennai, Giulia Trevisi Borsari, Tea Covic and Roberto Silingardi

    Citation: Stem Cell Research & Therapy 2019 10:223

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  38. Content type: Research

    iRoot BP Plus is a novel bioceramic endodontic material. Recently, it has been considered as an alternative to MTA which is the most popular scaffold cover during regenerative endodontic therapy. This study ai...

    Authors: Jiamin Lu, Zehan Li, Xiao Wu, Yan Chen, Ming Yan, Xingyun Ge and Jinhua Yu

    Citation: Stem Cell Research & Therapy 2019 10:222

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  39. Content type: Research

    Familial hypercholesterolemia type IIA (FH) is due to mutations in the low-density lipoprotein receptor (LDLR) resulting in elevated levels of low-density lipoprotein cholesterol (LDL-c) in plasma and in prema...

    Authors: Jérôme Caron, Véronique Pène, Laia Tolosa, Maxime Villaret, Eléanor Luce, Angélique Fourrier, Jean-Marie Heslan, Samir Saheb, Eric Bruckert, María José Gómez-Lechón, Tuan Huy Nguyen, Arielle R. Rosenberg, Anne Weber and Anne Dubart-Kupperschmitt

    Citation: Stem Cell Research & Therapy 2019 10:221

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  40. Content type: Research

    Human naïve pluripotency state cells can be derived from direct isolation of inner cell mass or primed-to-naïve resetting of human embryonic stem cells (hESCs) through different combinations of transcription f...

    Authors: Yingying Wang, Baosen Guo, Zengrong Xiao, Haijun Lin, Xi Zhang, Yueqiang Song, Yalei Li, Xuehu Gao, Jinjun Yu, Zhihua Shao, Xuekun Li, Yuping Luo and Siguang Li

    Citation: Stem Cell Research & Therapy 2019 10:220

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  41. Content type: Review

    Cancer remains one of the leading lethal diseases worldwide. Identifying biomarkers of cancers might provide insights into the strategies for the development of novel targeted anti-cancer therapies. Leucine-ri...

    Authors: Liangliang Xu, Weiping Lin, Longping Wen and Gang Li

    Citation: Stem Cell Research & Therapy 2019 10:219

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  42. Content type: Research

    Mesenchymal stem cells (MSCs) are attracting increasing interest for cell-based therapies, making use of both their immuno-modulating and regenerative potential. For such therapeutic applications, a massive in...

    Authors: Daniela Hladik, Ines Höfig, Ursula Oestreicher, Johannes Beckers, Martina Matjanovski, Xuanwen Bao, Harry Scherthan, Michael J. Atkinson and Michael Rosemann

    Citation: Stem Cell Research & Therapy 2019 10:218

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  43. Content type: Research

    Both genetic and environmental factors are implicated in the pathogenesis of cleft palate. However, the molecular and cellular mechanisms that regulate the development of palatal shelves, which are composed of...

    Authors: Lungang Shi, Binchen Li, Binna Zhang, Congyuan Zhen, Jianda Zhou and Shijie Tang

    Citation: Stem Cell Research & Therapy 2019 10:217

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  44. Content type: Research

    Temporomandibular joint osteoarthritis (TMJOA) is an inflammatory joint disease. This study investigated whether exosomes (Exos) of stem cells from human exfoliated deciduous teeth (SHEDs) have a therapeutic e...

    Authors: Ping Luo, Chao Jiang, Ping Ji, Menghong Wang and Jie Xu

    Citation: Stem Cell Research & Therapy 2019 10:216

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  45. Content type: Correction

    The original article [1] contains errors in Fig. 1. The authors noticed a potentially misleading aspect of the original article Fig. 1 where representative flow cytometry data for different panels were from di...

    Authors: Swati Paliwal, Rituparna Chaudhuri, Anurag Agrawal and Sujata Mohanty

    Citation: Stem Cell Research & Therapy 2019 10:215

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    The original article was published in Stem Cell Research & Therapy 2018 9:298

  46. Content type: Research

    To explore the mechanism of human umbilical cord-derived mesenchymal stem cell (hUMSC) transplantation to improve ovarian function and the endometrial receptivity in autoimmune premature ovarian failure (POF) ...

    Authors: Xueyan Lu, Jingjing Cui, Linlu Cui, Qianqian Luo, Qizhi Cao, Wendan Yuan and Hongqin Zhang

    Citation: Stem Cell Research & Therapy 2019 10:214

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  47. Content type: Research

    As the representative of fenamic acids, an important group of NSAIDs, flufenamic acid (FFA) has been used for anti-inflammation and analgesia in the clinic. Recently, researches have focused on the role of som...

    Authors: Xuenan Liu, Zheng Li, Hao Liu, Yuan Zhu, Dandan Xia, Siyi Wang, Ranli Gu, Weiliang Wu, Ping Zhang, Yunsong Liu and Yongsheng Zhou

    Citation: Stem Cell Research & Therapy 2019 10:213

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  48. Content type: Research

    Over 50% of acute stroke patients have hyperglycemia, which is associated with a poorer prognosis and outcome. Our aim was to investigate the impact of hyperglycemia on behavioral recovery and brain repair of ...

    Authors: Mari Carmen Gómez-de Frutos, Fernando Laso-García, Luke Diekhorst, Laura Otero-Ortega, Blanca Fuentes, Jukka Jolkkonen, Olivier Detante, Anaick Moisan, Arturo Martínez-Arroyo, Exuperio Díez-Tejedor and María Gutiérrez-Fernández

    Citation: Stem Cell Research & Therapy 2019 10:212

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  49. Content type: Research

    Autosomal recessive osteopetrosis is a genetically and phenotypically heterogeneous disease, caused by defects in osteoclast formation and function. The only available treatment is allogeneic stem cell transpl...

    Authors: Fatma Visal Okur, İnci Cevher, Cansu Özdemir, Çetin Kocaefe and Duygu Uçkan Çetinkaya

    Citation: Stem Cell Research & Therapy 2019 10:211

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  50. Content type: Research

    The goals of this study were to explore the expression profiles and functional networks of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in mesenchymal stromal cells (MSCs) involved in regulating t...

    Authors: Ming Li, Zhongyu Xie, Zhaopeng Cai, Fang Su, Guan Zheng, Jinteng Li, Shan Wang, Shuizhong Cen, Wenjie Liu, Su’an Tang, Guiwen Ye, Zhaofeng Li, Rujia Mi, Yiqian Pan, Peng Wang, Yanfeng Wu…

    Citation: Stem Cell Research & Therapy 2019 10:207

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Stem Cell Research & Therapy

ISSN: 1757-6512