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  1. Content type: Review

    Stem cell transplantation (SCT) has become a promising way to treat ischemic heart failure (IHF). We performed a large-scale meta-analysis of randomized clinical trials to investigate the efficacy and safety o...

    Authors: Yixuan Wang, Fen Xu, Jingwei Ma, Jiawei Shi, Si Chen, Zongtao Liu and Junwei Liu

    Citation: Stem Cell Research & Therapy 2019 10:125

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  2. Content type: Review

    Emerging evidence shows that epithelial-mesenchymal transition (EMT) plays a crucial role in tumor invasion, metastasis, cancer stem cells, and drug resistance. Data obtained thus far have revealed that F-box ...

    Authors: Yizuo Song, Min Lin, Yi Liu, Zhi-Wei Wang and Xueqiong Zhu

    Citation: Stem Cell Research & Therapy 2019 10:124

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  3. Content type: Research

    IL-33 is a pleiotropic cytokine of the IL-1 family, which has been reported to implicate in both innate and adaptive immune responses. Recent studies suggest IL-33 is crucial for regulation of myelopoiesis and...

    Authors: Ping Huang, Xiangyong Li, Ying Meng, Baohong Yuan, Tao Liu, Mengya Jiao, Xiaodi Wang, Yunjun Liu and Hui Yin

    Citation: Stem Cell Research & Therapy 2019 10:123

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  4. Content type: Research

    Sox2 is a well-established pluripotent transcription factor that plays an essential role in establishing and maintaining pluripotent stem cells (PSCs). It is also thought to be a linage specifier that governs ...

    Authors: Shuchen Zhang, Emma Bell, Huihan Zhi, Sarah Brown, Siti A. M. Imran, Véronique Azuara and Wei Cui

    Citation: Stem Cell Research & Therapy 2019 10:122

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  5. Content type: Research

    Retina and/or optic nerve injury may cause irreversible blindness, due to degeneration of retinal ganglion cells. We and others have previously shown that the intravitreal injection of mesenchymal stem cells (...

    Authors: Louise A. Mesentier-Louro, Leandro C. Teixeira-Pinheiro, Fernanda Gubert, Juliana F. Vasques, Almir J. Silva-Junior, Luiza Chimeli-Ormonde, Gabriel Nascimento-dos-Santos, Rosalia Mendez-Otero and Marcelo F. Santiago

    Citation: Stem Cell Research & Therapy 2019 10:121

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  6. Content type: Review

    In mammals, a basal level of autophagy, a self-eating cellular process, degrades cytosolic proteins and subcellular organelles in lysosomes to provide energy, recycles the cytoplasmic components, and regenerat...

    Authors: Chenxia Hu, Lingfei Zhao, Daxian Wu and Lanjuan Li

    Citation: Stem Cell Research & Therapy 2019 10:120

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  7. Content type: Review

    Stem cell-based therapy appears to be a promising new candidate for acute kidney injury (AKI) management. Traditionally, it has been accepted that the mechanism underlying the regenerative effect of stem cells...

    Authors: Lingfei Zhao, Chenxia Hu, Ping Zhang, Hua Jiang and Jianghua Chen

    Citation: Stem Cell Research & Therapy 2019 10:119

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  8. Content type: Research

    Adult stem cells exist in a quiescent state (G0) within the in vivo niche; the loss of quiescence often leads to a decrease in the number and function of adult stem cells, impairing tissue regeneration and rep...

    Authors: Bin Li, Chao Sun, Jing Sun, Ming-hui Yang, Rui Zuo, Chang Liu, Wei-ren Lan, Ming-han Liu, Bo Huang and Yue Zhou

    Citation: Stem Cell Research & Therapy 2019 10:118

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  9. Content type: Research

    Although adipocytes are the most abundant stromal cell component in breast cancer tissues, their interaction with breast cancer cells has been less investigated compared to cancer-associated fibroblasts or mac...

    Authors: Shihua Wang, Xiaodong Su, Meiqian Xu, Xian Xiao, Xiaoxia Li, Hongling Li, Armand Keating and Robert Chunhua Zhao

    Citation: Stem Cell Research & Therapy 2019 10:117

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  10. Content type: Research

    The mechanisms underpinning the regenerative capabilities of mesenchymal stem cells (MSC) were originally thought to reside in their ability to recognise damaged tissue and to differentiate into specific cell ...

    Authors: Robert Mitchell, Ben Mellows, Jonathan Sheard, Manuela Antonioli, Oliver Kretz, David Chambers, Marie-Theres Zeuner, James E. Tomkins, Bernd Denecke, Luca Musante, Barbara Joch, Florence Debacq-Chainiaux, Harry Holthofer, Steve Ray, Tobias B. Huber, Joern Dengjel…

    Citation: Stem Cell Research & Therapy 2019 10:116

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  11. Content type: Research

    Mesenchymal stem cells (MSCs) and their cellular response to various stimuli have been characterized in great detail in culture conditions. In contrast, the cellular response of MSCs in an in vivo setting is s...

    Authors: Ramil Hakim, Ruxandra Covacu, Vasilios Zachariadis, Arvid Frostell, Sreenivasa Raghavan Sankavaram, Lou Brundin and Mikael Svensson

    Citation: Stem Cell Research & Therapy 2019 10:115

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  12. Content type: Research

    Recent studies have shown that deficiency in the Fanconi anemia (FA) DNA repair pathway enhances the error-prone non-homologous end-joining (NHEJ) repair, leading to increased genomic instability, and that gen...

    Authors: Yan Nie, Yibo Li, Xiaoli Li, Andrew F. Wilson and Qishen Pang

    Citation: Stem Cell Research & Therapy 2019 10:114

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  13. Content type: Research

    Pluripotent stem cell-derived cardiomyocytes (PSC-CMs) are widely used models for regenerative medicine and disease research. However, PSC-CMs are usually immature in morphology and functionality and the matur...

    Authors: Rou Chen, Jun He, Yumei Wang, You Guo, Juan Zhang, Luying Peng, Duo Wang, Qin Lin, Jie Zhang, Zheng Guo and Li Li

    Citation: Stem Cell Research & Therapy 2019 10:113

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  14. Content type: Research

    New insights on cellular and molecular aspects of both oligodendrocyte (OL) differentiation and myelin synthesis pathways are potential avenues for developing a cell-based therapy for demyelinating disorders c...

    Authors: Negin Afrang, Rezvan Tavakoli, Nooshin Tasharrofi, Amir Alian, Alireza Naderi Sohi, Mahboubeh Kabiri, Mehrnoosh Fathi-Roudsari, Mina Soufizomorrod, Farzad Rajaei, Masoud Soleimani and Fatemeh Kouhkan

    Citation: Stem Cell Research & Therapy 2019 10:112

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  15. Content type: Review

    Normal wound healing is a dynamic and complex multiple phase process involving coordinated interactions between growth factors, cytokines, chemokines, and various cells. Any failure in these phases may lead wo...

    Authors: Azar Nourian Dehkordi, Fatemeh Mirahmadi Babaheydari, Mohammad Chehelgerdi and Shiva Raeisi Dehkordi

    Citation: Stem Cell Research & Therapy 2019 10:111

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  16. Content type: Research

    Synthetic implants are being used to restore injured or damaged tissues following cancer resection and congenital diseases. However, the survival of large tissue implant replacements depends on their ability t...

    Authors: M. F. Griffin, N. Naderi, D. M. Kalaskar, A. M. Seifalian and P. E. Butler

    Citation: Stem Cell Research & Therapy 2019 10:110

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  17. Content type: Research

    Osteoarthritis (OA) is the most prevalent joint disease, and to date, no options for effective tissue repair and restoration are available. With the aim of developing new therapies, the impact of mesenchymal s...

    Authors: Enrico Ragni, Carlotta Perucca Orfei, Paola De Luca, Gaia Lugano, Marco Viganò, Alessandra Colombini, Federico Valli, Daniele Zacchetti, Valentina Bollati and Laura de Girolamo

    Citation: Stem Cell Research & Therapy 2019 10:109

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  18. Content type: Research

    Tendons are a crucial component of the musculoskeletal system and responsible for transmission forces derived from muscle to bone. Patients with tendon injuries are often observed with decreased collagen produ...

    Authors: Yang Liu, Lu Feng, Jia Xu, Zhengmeng Yang, Tianyi Wu, Jiajun Zhang, Liu Shi, Dahai Zhu, Jinfang Zhang and Gang Li

    Citation: Stem Cell Research & Therapy 2019 10:108

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  19. Content type: Research

    Intrauterine adhesion (IUA) is characterized by progressive intrauterine fibrosis as a consequence of trauma to the basal layer of the endometrium. In an attempt to relieve IUA, many approaches have been appli...

    Authors: Xing Chen, Jingtao Sun, Xiaoyu Li, Lele Mao, Lei Cui and Wenpei Bai

    Citation: Stem Cell Research & Therapy 2019 10:107

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  20. Content type: Research

    Human adipose-derived stem cells (hADSCs) are an important source of cells for regenerative medicine. Evidence of extensive interactions with the surrounding microenvironment has led researchers to focus more ...

    Authors: Fen Xu, Qinqin Xiang, Jiuzuo Huang, Qianlong Chen, Nanze Yu, Xiao Long and Zhou Zhou

    Citation: Stem Cell Research & Therapy 2019 10:106

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  21. Content type: Research

    Preterm newborns are at high risk of developing neurodevelopmental deficits caused by neuroinflammation leading to perinatal brain injury. Human Wharton’s jelly mesenchymal stem cells (hWJ-MSC) derived from th...

    Authors: Gierin Thomi, Daniel Surbek, Valérie Haesler, Marianne Joerger-Messerli and Andreina Schoeberlein

    Citation: Stem Cell Research & Therapy 2019 10:105

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  22. Content type: Research

    Putative endothelial progenitor cells (pEPCs) have been confirmed to participate in alleviation of renal fibrosis in several ischaemic diseases. However, their mechanistic effect on renal fibrosis, which is ch...

    Authors: Juan Yang, Meng Wang, Fengming Zhu, Jie Sun, Huzi Xu, Octavia Li-Sien Chong Lee Shin, Zhi Zhao, Guangchang Pei, Han Zhu, Chujin Cao, Xiaofeng He, Yi Huang, Zufu Ma, Liu Liu, Le Wang, Yong Ning…

    Citation: Stem Cell Research & Therapy 2019 10:104

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  23. Content type: Research

    Premature ovarian insufficiency is a common complication of anticancer treatments in young women and girls. The ovary is a complex, highly regulated reproductive organ, whose proper function is contingent upon...

    Authors: Lisa J. Green, Hong Zhou, Vasantha Padmanabhan and Ariella Shikanov

    Citation: Stem Cell Research & Therapy 2019 10:102

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  24. Content type: Research

    The ex vivo expansion potential of mesenchymal stromal/stem cells (MSC) together with their differentiation and secretion properties makes these cells an attractive tool for transplantation and tissue engineer...

    Authors: Elisabetta Manuela Foppiani, Olivia Candini, Ilenia Mastrolia, Alba Murgia, Giulia Grisendi, Anna Valeria Samarelli, Giulia Boscaini, Lucrezia Pacchioni, Massimo Pinelli, Giorgio De Santis, Edwin M. Horwitz, Elena Veronesi and Massimo Dominici

    Citation: Stem Cell Research & Therapy 2019 10:101

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  25. Content type: Research

    Primary mesenchymal stem cells (MSCs) are fraught with aging-related shortfalls. Human-induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) have been shown to be a useful clinically relevant source of MSC...

    Authors: Lucas-Sebastian Spitzhorn, Matthias Megges, Wasco Wruck, Md Shaifur Rahman, Jörg Otte, Özer Degistirici, Roland Meisel, Rüdiger Volker Sorg, Richard O. C. Oreffo and James Adjaye

    Citation: Stem Cell Research & Therapy 2019 10:100

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  26. Content type: Research

    The manufacture of mesenchymal stem/stromal cells (MSCs) for clinical use needs to be cost effective, safe and scaled up. Current methods of expansion on tissue culture plastic are labour-intensive and involve...

    Authors: Claire Mennan, John Garcia, Sally Roberts, Charlotte Hulme and Karina Wright

    Citation: Stem Cell Research & Therapy 2019 10:99

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  27. Content type: Research

    Mesenchymal stem cells (MSCs) are increasingly being applied as a therapy for liver fibrosis. Exosomes possess similar functions to their parent cells; however, they are safe and effective cell-free reagents w...

    Authors: Xiaoli Rong, Junzhi Liu, Xia Yao, Tiechao Jiang, Yimin Wang and Feng Xie

    Citation: Stem Cell Research & Therapy 2019 10:98

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  28. Content type: Correction

    The original article [1] was submitted and published without co-author Hong Chen’s permission.

    Authors: Xuejiao Sun, Jianyuan Song, Hailong Huang, Hong Chen and Kun Qian

    Citation: Stem Cell Research & Therapy 2019 10:97

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    The original article was published in Stem Cell Research & Therapy 2018 9:315

  29. Content type: Research

    Studies have shown that transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) protects against brain damage. However, the low survival number of transplanted BMSCs remains a pertinent challenge...

    Authors: Jiangnan Hu, Lefu Chen, Xujun Huang, Ke Wu, Saidan Ding, Weikan Wang, Brian Wang, Charity Smith, Changhong Ren, Haoqi Ni, Qichuan ZhuGe and Jianjing Yang

    Citation: Stem Cell Research & Therapy 2019 10:96

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  30. Content type: Research

    It is confirmed that adipose-derived stem cells (ADSCs) transplantation effectively relieves kidney fibrosis and type 2 diabetes disease in mice. Currently, exosome from urine-derived stem cells (USCs) can pro...

    Authors: Juan Jin, Yifen Shi, Jianguang Gong, Li Zhao, Yiwen Li, Qiang He and He Huang

    Citation: Stem Cell Research & Therapy 2019 10:95

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  31. Content type: Review

    The skin is the largest organ of the body, which meets the environment most directly. Thus, the skin is vulnerable to various damages, particularly burn injury. Skin wound healing is a serious interaction betw...

    Authors: Anastasia Shpichka, Denis Butnaru, Evgeny A. Bezrukov, Roman B. Sukhanov, Anthony Atala, Vitaliy Burdukovskii, Yuanyuan Zhang and Peter Timashev

    Citation: Stem Cell Research & Therapy 2019 10:94

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  32. Content type: Research

    Adipose-derived mesenchymal stromal cells (ADSCs) are multipotent stromal cells. The cells secrete a number of cytokines and growth factors and show immunoregulatory and proangiogenic properties. Their propert...

    Authors: Ewelina Pilny, Ryszard Smolarczyk, Magdalena Jarosz-Biej, Alina Hadyk, Agnieszka Skorupa, Mateusz Ciszek, Łukasz Krakowczyk, Natalia Kułach, Danuta Gillner, Maria Sokół, Stanisław Szala and Tomasz Cichoń

    Citation: Stem Cell Research & Therapy 2019 10:93

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  33. Content type: Research

    Vascular injury is one of the most common detrimental effects of cancer radiotherapy on healthy tissues. Since the efficacy of current preventive and therapeutic strategies remains limited, the exploration of ...

    Authors: Xuan Tao, Mingyang Sun, Min Chen, Rongchao Ying, Wenjie Su, Jian Zhang, Xiaodong Xie, Wei Wei and Xiaohu Meng

    Citation: Stem Cell Research & Therapy 2019 10:92

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  34. Content type: Research

    Adipose-derived mesenchymal stem cells (ADMSCs) are considered an efficient and important candidate for male infertility treatment because they contain pluripotent stem cells, which can differentiate into all ...

    Authors: Yanxia Luo, Lili Xie, Ali Mohsin, Waqas Ahmed, Chenze Xu, Yan Peng, Haifeng Hang, Yingping Zhuang, Ju Chu and Meijin Guo

    Citation: Stem Cell Research & Therapy 2019 10:91

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  35. Content type: Research

    Sulfur mustard (SM) is a notorious chemical warfare agent that can cause severe acute lung injury (ALI), in addition to other lesions. Currently, effective medical countermeasures for SM are lacking. Bone marr...

    Authors: Yongwei Feng, Qingqiang Xu, Yuyan Yang, Wenwen Shi, Wenqi Meng, Hao Zhang, Xiaowen He, Mingxue Sun, Yongchun Chen, Jie Zhao, Zhenhong Guo and Kai Xiao

    Citation: Stem Cell Research & Therapy 2019 10:90

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  36. Content type: Research

    Human dental pulp stem cell (DPSC)-mediated regenerative endodontics is a promising therapy for damaged teeth; however, the hypoxic environment in root canals can affect tissue regeneration. In this study, we ...

    Authors: Ruitang Shi, Haoqing Yang, Xiao Lin, Yangyang Cao, Chen Zhang, Zhipeng Fan and Benxiang Hou

    Citation: Stem Cell Research & Therapy 2019 10:89

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  37. Content type: Research

    Human mesenchymal stem cell (MSC)-based tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene delivery is regarded as an effective treatment for glioblastoma (GBM). However, adverse-free target ...

    Authors: Man Li, Shoujia Sun, Sean Dangelmajer, Quan Zhang, Junwen Wang, Feng Hu, Fangyong Dong, Ulf D. Kahlert, Mingxin Zhu and Ting Lei

    Citation: Stem Cell Research & Therapy 2019 10:88

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  38. Content type: Review

    Wound healing is the physiologic response to a disruption in normal skin architecture and requires both spatial and temporal coordination of multiple cell types and cytokines. This complex process is prone to ...

    Authors: Jolanta Gorecka, Valentyna Kostiuk, Arash Fereydooni, Luis Gonzalez, Jiesi Luo, Biraja Dash, Toshihiko Isaji, Shun Ono, Shirley Liu, Shin Rong Lee, Jianbiao Xu, Jia Liu, Ryosuke Taniguchi, Bogdan Yastula, Henry C. Hsia, Yibing Qyang…

    Citation: Stem Cell Research & Therapy 2019 10:87

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  39. Content type: Research

    Senescent cells exert a significant influence over their surrounding cellular environment. Senescent chondrocytes (SnChos) were found to be accumulated in degenerated cartilage present in joints affected by os...

    Authors: Xu Cao, Pan Luo, Junjie Huang, Chi Liang, Jinshen He, Zili Wang, Dongyong Shan, Cheng Peng and Song Wu

    Citation: Stem Cell Research & Therapy 2019 10:86

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  40. Content type: Research

    Islets of Langerhans transplantation is a promising therapy for type 1 diabetes mellitus, but this technique is compromised by transplantation stresses including inflammation. In other tissues, co-transplantat...

    Authors: Camille Laporte, Emily Tubbs, Justine Cristante, Anne-Sophie Gauchez, Sandra Pesenti, Frédéric Lamarche, Cécile Cottet-Rousselle, Catherine Garrel, Anaick Moisan, Jean-Marc Moulis, Eric Fontaine, Pierre-Yves Benhamou and Sandrine Lablanche

    Citation: Stem Cell Research & Therapy 2019 10:85

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  41. Content type: Research

    Acute liver failure (ALF) is a complicated clinical syndrome associated with high mortality, with liver transplantation as the only treatment option. Treatment of mesenchymal stem cells has shown a potential t...

    Authors: Gang Guo, Xiang Zhuang, Qing Xu, Zhenru Wu, Yongjie Zhu, Yongjie Zhou, Yuanmin Li, Yanrong Lu, Bo Zhang, Prue Talbot, Jiayu Liao, Junjun She, Hong Bu and Yujun Shi

    Citation: Stem Cell Research & Therapy 2019 10:84

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  42. Content type: Method

    A well-characterized method has not yet been established to reproducibly, efficiently, and safely isolate large numbers of clinical-grade multipotent human neural stem cells (hNSCs) from embryonic stem cells (...

    Authors: Dasa Bohaciakova, Marian Hruska-Plochan, Rachel Tsunemoto, Wesley D. Gifford, Shawn P. Driscoll, Thomas D. Glenn, Stephanie Wu, Silvia Marsala, Michael Navarro, Takahiro Tadokoro, Stefan Juhas, Jana Juhasova, Oleksandr Platoshyn, David Piper, Vickie Sheckler, Dara Ditsworth…

    Citation: Stem Cell Research & Therapy 2019 10:83

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  43. Content type: Research

    Bone marrow stromal cells (BMSCs) are extensively used in regeneration therapy and cytology experiments simulate how BMSCs respond to radiation. Due to the small number and the heterogeneity of primary isolate...

    Authors: Yang Xiang, Chun Wu, Jiang Wu, Weili Quan, Chao Cheng, Jian Zhou, Li Chen, Lixin Xiang, Fengjie Li, Kebin Zhang, Qian Ran, Yi Zhang and Zhongjun Li

    Citation: Stem Cell Research & Therapy 2019 10:82

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  44. Content type: Research

    Embryonic Sertoli cells (eSCs) play an important role in sex determination and in male gonad development which makes them a very useful cell type for therapeutic applications. However, the deriving mechanism o...

    Authors: Chenze Xu, Ali Mohsin, Yanxia Luo, Lili Xie, Yan Peng, Qizheng Wang, Haifeng Hang, Yingping Zhuang and Meijin Guo

    Citation: Stem Cell Research & Therapy 2019 10:81

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  45. Content type: Research

    Previous studies revealed that urine-derived stem cells (USCs) could promote myogenesis after the impairment of the sphincter muscles. However, the effects of exosomes secreted by USCs (USCs-Exo) were not eluc...

    Authors: Ruoyu Wu, Chengsheng Huang, Qingkai Wu, Xiang Jia, Mengyu Liu, Zhuowei Xue, Yu Qiu, Xin Niu and Yang Wang

    Citation: Stem Cell Research & Therapy 2019 10:80

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  46. Content type: Research

    Mesenchymal stromal cells (MSCs) are considered potential candidates that hold great promise in the treatment of immune-related diseases. For therapeutic applications, it is necessary to isolate and expand MSC...

    Authors: Sermporn Thaweesapphithak, Chairat Tantrawatpan, Pakpoom Kheolamai, Duangrat Tantikanlayaporn, Sittiruk Roytrakul and Sirikul Manochantr

    Citation: Stem Cell Research & Therapy 2019 10:79

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  47. Content type: Research

    Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation of human embryonic stem cell-derived car...

    Authors: Songyan Liao, Yuelin Zhang, Sherwin Ting, Zhe Zhen, Fan Luo, Ziyi Zhu, Yu Jiang, Sijia Sun, Wing-Hon Lai, Qizhou Lian and Hung-Fat Tse

    Citation: Stem Cell Research & Therapy 2019 10:78

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  48. Content type: Research

    Numerous studies from different labs around the world report human cardiac progenitor cells (hCPCs) as having a role in myocardial repair upon ischemia/reperfusion (I/R) injury, mainly through auto/paracrine s...

    Authors: Maria J. Sebastião, Margarida Serra, Rute Pereira, Itziar Palacios, Patrícia Gomes-Alves and Paula M. Alves

    Citation: Stem Cell Research & Therapy 2019 10:77

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  49. Content type: Correction

    The original article [1] contains an accidental omission in the Acknowledgements.

    Authors: Fei Zhou, Shane Gao, Lin Wang, Chenxi Sun, Lu Chen, Ping Yuan, Haiyang Zhao, Yi Yi, Ying Qin, Zhiqiang Dong, Limei Cao, Haiyan Ren, Liang Zhu, Qiang Li, Bing Lu, Aibin Liang…

    Citation: Stem Cell Research & Therapy 2019 10:76

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    The original article was published in Stem Cell Research & Therapy 2015 6:92

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