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  1. Retinal degeneration is a leading cause of blindness in the world; its etiology is complex and involves genetic defects and stress-associated aging. In addition to gene therapies for known genetically defectiv...

    Authors: Xiao Liu, Fenghua Chen, Yao Chen, Huayi Lu, Xiaoqin Lu, Xiaoyan Peng, Henry J. Kaplan, Douglas C. Dean, Ling Gao and Yongqing Liu

    Citation: Stem Cell Research & Therapy 2020 11:142

    Content type: Research

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  2. Three-dimensional (3D) cultivation with biomaterials was proposed to facilitate stem cell epithelial differentiation for wound healing. However, whether human adipose-derived stem cells (hASCs) on collagen spo...

    Authors: Minxiong Li, Jun Ma, Yanbin Gao, Mengru Dong, Zijun Zheng, Yuchen Li, Rongwei Tan, Zhending She and Lei Yang

    Citation: Stem Cell Research & Therapy 2020 11:141

    Content type: Research

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  3. Glucocorticoid (GC)-associated osteonecrosis of the femoral head (ONFH) is the most common in non-traumatic ONFH. Despite a strong relationship between GC and ONFH, the detailed mechanisms have remained elusiv...

    Authors: Xudong Yao, Shengnan Yu, Xingzhi Jing, Jiachao Guo, Kai Sun, Fengjing Guo and Yaping Ye

    Citation: Stem Cell Research & Therapy 2020 11:140

    Content type: Research

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  4. To date, many attempts are employed to increase the regenerative potential of stem cells. In this study, we evaluated the hypothesis of whether an autophagy modulation could alter differentiation potency of CD146

    Authors: Mehdi Hassanpour, Jafar Rezaie, Masoud Darabi, Amirataollah Hiradfar, Reza Rahbarghazi and Mohammad Nouri

    Citation: Stem Cell Research & Therapy 2020 11:139

    Content type: Research

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  5. Receptor tyrosine kinase-like orphan receptor 2 (Ror2) plays a key role in bone formation, but its signaling pathway is not completely understood. Signal transducer and activator of transcription 3 (Stat3) tak...

    Authors: Lizhen Lei, Zhuwei Huang, Jingyi Feng, Zijing Huang, Yiwei Tao, Xiaoli Hu and Xiaolei Zhang

    Citation: Stem Cell Research & Therapy 2020 11:137

    Content type: Research

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  6. Due to the low survival rate of cell transplantation, stem cell has not been widely used in clinical treatment of acute myocardial infarction (AMI). In this study, we immobilized the C domain peptide of insuli...

    Authors: Yong Yao, Liang Yang, Li-feng Feng, Zhi-wei Yue, Nian-huan Zhao, Zongjin Li and Zuo-xiang He

    Citation: Stem Cell Research & Therapy 2020 11:136

    Content type: Research

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  7. Bone defects are a common clinical condition that has gained an increasing amount of attention in recent years. Causes of bone defect include tumors, inflammation, and fractures. Bone tissue engineering is a n...

    Authors: Yuan Zhu, Xiao Zhang, Ranli Gu, Xuenan Liu, Siyi Wang, Dandan Xia, Zheng Li, Xiaomin Lian, Ping Zhang, Yunsong Liu and Yongsheng Zhou

    Citation: Stem Cell Research & Therapy 2020 11:135

    Content type: Research

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  8. Human deciduous pulp stem cells (hDPSCs) have remarkable stem cell potency associated with cell proliferation, mesenchymal multipotency, and immunosuppressive function and have shown beneficial effects in a va...

    Authors: Tsuyoshi Iwanaka, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Shouichi Ohga, Yoshinao Oda and Tomoaki Taguchi

    Citation: Stem Cell Research & Therapy 2020 11:134

    Content type: Research

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  9. In our previous research, we found that mesenchymal stem cell (MSC) transplantation therapy can inhibit intimal hyperplasia and enhance endothelial function in arterialized vein grafts in rats. However, whethe...

    Authors: Qingxi Qu, Yingxin Pang, Chunmei Zhang, Linghong Liu and Yanwen Bi

    Citation: Stem Cell Research & Therapy 2020 11:133

    Content type: Research

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  10. Myelodysplastic syndrome (MDS) represents a heterogeneous group of clonal hematopoietic disorders, which is characterized by cytopenias in the peripheral blood and bone marrow dysplasia due to ineffective hema...

    Authors: Khaja Syed, Sara Naguib, Zhao-Jun Liu, Luisa Cimmino and Feng-Chun Yang

    Citation: Stem Cell Research & Therapy 2020 11:132

    Content type: Review

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  11. Hypercholesterolemia increases the risk of tendon pain and tendon rupture. Tendon-derived stem cells (TDSCs) play a vital role in the development of tendinopathy. Our previous research found that high choleste...

    Authors: Kaiqun Li, Ye Deng, Ganming Deng, Pengyu Chen, Yutian Wang, Hangtian Wu, Zhiguo Ji, Zilong Yao, Xianrong Zhang, Bin Yu and Kairui Zhang

    Citation: Stem Cell Research & Therapy 2020 11:131

    Content type: Research

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  12. Mesenchymal stem cells (MSCs) have been reported to promote the regeneration of injured tissue via their paracrine abilities, which are enhanced by hypoxic preconditioning. In this study, we examined the thera...

    Authors: Naoki Ishiuchi, Ayumu Nakashima, Shigehiro Doi, Ken Yoshida, Satoshi Maeda, Ryo Kanai, Yumi Yamada, Takeshi Ike, Toshiki Doi, Yukio Kato and Takao Masaki

    Citation: Stem Cell Research & Therapy 2020 11:130

    Content type: Research

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  13. Distraction osteogenesis (DO) is a surgical technique to promote bone regeneration which may require long duration for bone consolidation. Bone marrow-derived mesenchymal stem cells (MSCs) have been applied to...

    Authors: Yanhua Yang, Qi Pan, Kaijie Zou, Haixing Wang, Xiaoting Zhang, Zhengmeng Yang, Wayne Yuk Wai Lee, Bo Wei, Weidong Gu, Yunzhi Peter Yang, Sien Lin and Gang Li

    Citation: Stem Cell Research & Therapy 2020 11:129

    Content type: Research

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  14. Vocal fold (VF) scarring, caused by surgery or inflammation, often results in severe voice problems or aphonia. Effective lasting treatment is lacking. Previous in vitro and in vivo animal studies reported pos...

    Authors: Stellan Hertegård, Srinivasa Rau Nagubothu, Emma Malmström and Katarina LeBlanc

    Citation: Stem Cell Research & Therapy 2020 11:128

    Content type: Research

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  15. Organ replacement regenerative therapy based on human adult stem cells may be effective for salivary gland hypofunction. However, the generated tissues are immature because the signaling factors that induce th...

    Authors: Yi Sui, Siqi Zhang, Yongliang Li, Xin Zhang, Waner Hu, Yanrui Feng, Jingwei Xiong, Yuanyuan Zhang and Shicheng Wei

    Citation: Stem Cell Research & Therapy 2020 11:127

    Content type: Research

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  16. The discovery of induced pluripotent stem cells (iPSCs) opened the possibilities for reprogramming cells back to a pluripotent state. Because of no apparent ethical issues connected with donation and derivatio...

    Authors: Marcin Orzechowski, Maximilian Schochow, Michael Kühl and Florian Steger

    Citation: Stem Cell Research & Therapy 2020 11:126

    Content type: Research

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  17. Mesenchymal stem cells (MSCs) have been intensively investigated as to their therapeutic potentials. However, the full chemical-defined medium supporting the isolation and expansion of human MSCs has not been ...

    Authors: Jianyong Xu, Wei Lian, Jieting Chen, Wenlei Li, Lingyun Li and Zhong Huang

    Citation: Stem Cell Research & Therapy 2020 11:125

    Content type: Research

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  18. Crohn’s fistula-in-ano is a refractory disease in colorectal and anal surgery. Although autologous adipose-derived stem cell (ADSC) has been used in the treatment of Crohn’s fistula-in-ano because of its conve...

    Authors: Chungen Zhou, Meng Li, Yang Zhang, Min Ni, Yehuang Wang, Dachao Xu, Yang Shi, Bo Zhang, Yanni Chen, Yan Huang, Sumin Zhang, Hongzhen Shi and Bin Jiang

    Citation: Stem Cell Research & Therapy 2020 11:124

    Content type: Research

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  19. Autologous cellular immunotherapy or immune enhancement therapy has demonstrated some promising benefits for prostate cancer. T cell-based immunotherapy or sipuleucel-T therapy has yielded certain beneficial r...

    Authors: Zhu Wang, Youjia Li, Yuliang Wang, Dinglan Wu, Alaster Hang Yung Lau, Pan Zhao, Chang Zou, Yong Dai and Franky Leung Chan

    Citation: Stem Cell Research & Therapy 2020 11:123

    Content type: Research

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  20. Diabetic cardiomyopathy (DCM) is a cardiac complication of long-term uncontrolled diabetes and is characterized by myocardial fibrosis and abnormal cardiac function. Mesenchymal stem cells (MSCs) are multipote...

    Authors: Liyuan Jin, Jinying Zhang, Zihui Deng, Jiejie Liu, Weidong Han, Guanghui Chen, Yiling Si and Ping Ye

    Citation: Stem Cell Research & Therapy 2020 11:122

    Content type: Research

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  21. In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, ...

    Authors: María García-Bonilla, Betsaida Ojeda-Pérez, María L. García-Martín, M. Carmen Muñoz-Hernández, Javier Vitorica, Sebastián Jiménez, Manuel Cifuentes, Leonor Santos-Ruíz, Kirill Shumilov, Silvia Claros, Antonia Gutiérrez, Patricia Páez-González and Antonio J. Jiménez

    Citation: Stem Cell Research & Therapy 2020 11:121

    Content type: Research

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  22. Adipose-derived mesenchymal stem cells (ASCs) therapy is emerging as a novel therapeutic option for the treatment of a variety of diseases including diabetes and diabetic wound healing. Multiple studies indica...

    Authors: Ran An, Yong Zhang, Yu Qiao, Lili Song, Hongjun Wang and Xiao Dong

    Citation: Stem Cell Research & Therapy 2020 11:120

    Content type: Research

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  23. Though accumulated evidence has demonstrated visceral organ involvement in acute graft-versus-host disease (aGVHD), how aGVHD influences the bone marrow (BM) niche and the reconstitution of hematopoiesis post-...

    Authors: Li Ding, Hong-Mei Ning, Pei-Lin Li, Hong-Min Yan, Dong-Mei Han, Xiao-Li Zheng, Jing Liu, Ling Zhu, Mei Xue, Ning Mao, Zi-Kuan Guo, Heng Zhu and Heng-Xiang Wang

    Citation: Stem Cell Research & Therapy 2020 11:119

    Content type: Research

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  24. Oral squamous cell carcinoma (OSCC) is associated with high morbidity and ranks sixth among malignancies worldwide. Increasing evidence suggests that microRNAs (miRNAs or miRs) play a critical role in regulati...

    Authors: Xiaolong You, Zhengyu Zhou, Wen Chen, Xiaoyong Wei, Heqiang Zhou and Wenzheng Luo

    Citation: Stem Cell Research & Therapy 2020 11:117

    Content type: Research

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  25. The production of large quantities of cardiomyocyte is essential for the needs of cellular therapies. This study describes the selection of a human-induced pluripotent cell (hiPSC) line suitable for production...

    Authors: Filip Laco, Alan Tin-Lun Lam, Tsung-Liang Woo, Gerine Tong, Valerie Ho, Poh-Loong Soong, Elina Grishina, Kun-Han Lin, Shaul Reuveny and Steve Kah-Weng Oh

    Citation: Stem Cell Research & Therapy 2020 11:118

    Content type: Research

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  26. Mesenchymal stromal cells (MSCs) demonstrate considerable promise for acute respiratory distress syndrome (ARDS) and sepsis. However, standard approaches to MSC isolation generate highly heterogeneous cell pop...

    Authors: Shahd Horie, Claire Masterson, Jack Brady, Paul Loftus, Emma Horan, Lisa O’Flynn, Steve Elliman, Frank Barry, Timothy O’Brien, John G. Laffey and Daniel O’Toole

    Citation: Stem Cell Research & Therapy 2020 11:116

    Content type: Research

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  27. The ability of mesenchymal stem cells (MSCs) to modulate immune responses inspired a series of clinical trials addressing oral mucosal inflammation. We previously reported on the safety and efficacy of fresh, ...

    Authors: Boaz Arzi, Santiago Peralta, Nadine Fiani, Natalia Vapniarsky, Nopmanee Taechangam, Ubaldo Delatorre, Kaitlin C. Clark, Naomi J. Walker, Megan R. Loscar, Milinda J. Lommer, Amy Fulton, Jean Battig and Dori L. Borjesson

    Citation: Stem Cell Research & Therapy 2020 11:115

    Content type: Research

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  28. Long noncoding RNAs (lncRNAs) play an important role in the multiple differentiations of mesenchymal stem cells (MSCs). However, few studies have focused on the regulatory mechanism of lncRNAs in the odontogen...

    Authors: Zhao Chen, Kaiying Zhang, Wei Qiu, Yifei Luo, Yuhua Pan, Jianjia Li, Yeqing Yang, Buling Wu and Fuchun Fang

    Citation: Stem Cell Research & Therapy 2020 11:114

    Content type: Research

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  29. Microvesicles (MVs) derived from human Wharton’s jelly mesenchymal stem cells (MSC-MVs) were demonstrated to ameliorate acute lung injury (ALI). We have previously found that MSC-MV-transferred hepatocyte grow...

    Authors: Wen-xia Chen, Jun Zhou, Sha-sha Zhou, Yu-dan Zhang, Tong-yu Ji, Xiao-li Zhang, Shu-min Wang, Tao Du and De-gang Ding

    Citation: Stem Cell Research & Therapy 2020 11:113

    Content type: Research

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  30. Tooth movement is a unique bone remodeling process induced by mechanical stimulation. Macrophages are important in mediating inflammatory processes during mechanical load-induced tooth movement. However, how m...

    Authors: Danqing He, Fuliang Liu, Shengjie Cui, Nan Jiang, Huajie Yu, Yanheng Zhou, Yan Liu and Xiaoxing Kou

    Citation: Stem Cell Research & Therapy 2020 11:112

    Content type: Research

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  31. Although dental pulp stem cells (DPSCs) isolated from periodontally compromised teeth (P-DPSCs) have been demonstrated to retain pluripotency and regenerative potential, their use as therapeutics remains large...

    Authors: Huan Zhou, Xuan Li, Yuan Yin, Xiao-Tao He, Ying An, Bei-Min Tian, Yong-Long Hong, Li-An Wu and Fa-Ming Chen

    Citation: Stem Cell Research & Therapy 2020 11:110

    Content type: Research

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  32. Bone diseases such as osteoarthritis, osteoporosis, and bone tumor present a severe public health problem. Osteogenic differentiation is a complex process associated with the differentiation of different cells...

    Authors: Liyuan Yu, Kai Xia, Xiao Cen, Xinqi Huang, Wentian Sun, Zhihe Zhao and Jun Liu

    Citation: Stem Cell Research & Therapy 2020 11:109

    Content type: Review

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  33. Critical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by the blockade of arteries supplying blood to the lower extremities, significantly dim...

    Authors: Lucia Beltran-Camacho, Margarita Jimenez-Palomares, Marta Rojas-Torres, Ismael Sanchez-Gomar, Antonio Rosal-Vela, Sara Eslava-Alcon, Mª Carmen Perez-Segura, Ana Serrano, Borja Antequera-González, Jose Angel Alonso-Piñero, Almudena González-Rovira, Mª Jesús Extremera-García, Manuel Rodriguez-Piñero, Rafael Moreno-Luna, Martin Røssel Larsen and Mª Carmen Durán-Ruiz

    Citation: Stem Cell Research & Therapy 2020 11:106

    Content type: Research

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  34. The use of mesenchymal stromal cells (MSCs) for research and clinical application is hampered by cellular heterogeneity and replicative senescence. Generation of MSC-like cells from induced pluripotent stem ce...

    Authors: Jonathan Hollmann, Johanna Brecht, Roman Goetzke, Julia Franzen, Anton Selich, Marco Schmidt, Monika Eipel, Alina Ostrowska, Jan Hapala, Eduardo Fernandez-Rebollo, Gerhard Müller-Newen, Michael Rothe, Thomas Eggermann, Martin Zenke and Wolfgang Wagner

    Citation: Stem Cell Research & Therapy 2020 11:105

    Content type: Research

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  35. Autologous bone marrow stem cell (ABMSC) transplantation has been considered a promising option for hepatitis B virus-related cirrhosis (HBV-C). Although an analysis of the published literature has been perfor...

    Authors: Ani Sun, Wenni Gao and Ting Xiao

    Citation: Stem Cell Research & Therapy 2020 11:104

    Content type: Research

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  36. In mammals, specification of primordial germ cells (PGCs) is established in the early post­implantation embryo. The bone morphogenetic protein (BMP)-SMAD and WNT3-β-catenin signaling initiate the gene regulato...

    Authors: Fang Fang, Zili Li, Qian Zhao, Chengliang Xiong and Ke Ni

    Citation: Stem Cell Research & Therapy 2020 11:100

    Content type: Research

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  37. Equine amniotic mesenchymal stromal cells (AMSCs) and their conditioned medium (CM) were evaluated for their ability to inhibit in vitro proliferation of peripheral blood mononuclear cells (PBMCs) with and withou...

    Authors: Anna Lange-Consiglio, Pietro Romele, Marta Magatti, Antonietta Silini, Antonella Idda, Nicola Antonio Martino, Fausto Cremonesi and Ornella Parolini

    Citation: Stem Cell Research & Therapy 2020 11:99

    Content type: Research

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  38. Retinitis pigmentosa (RP) is an inherited retinal disease characterized by progressive loss of photoreceptor cells. This study aim at exploring the effect of retinal pigment epithelium (RPE) derived from human...

    Authors: Deliang Zhu, Mengyuan Xie, Fabian Gademann, Jixing Cao, Peiyuan Wang, Yonglong Guo, Lan Zhang, Ting Su, Jun Zhang and Jiansu Chen

    Citation: Stem Cell Research & Therapy 2020 11:98

    Content type: Research

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  39. Hypoxia is a major cause of beta cell death and dysfunction after transplantation. The aim of this study was to investigate the effect of exosomes derived from mesenchymal stem cells (MSCs) on beta cells under...

    Authors: Jin Chen, Junqiu Chen, Yuanhang Cheng, Yunfeng Fu, Hongzhou Zhao, Minying Tang, Hu Zhao, Na Lin, Xiaohua Shi, Yan Lei, Shuiliang Wang, Lianghu Huang, Weizhen Wu and Jianming Tan

    Citation: Stem Cell Research & Therapy 2020 11:97

    Content type: Research

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  40. Organoids are three-dimensional in vitro-grown cell clusters that recapitulate key features of native organs. In regenerative medicine, organoid technology represents a promising approach for the replacement o...

    Authors: Marta Dossena, Roberta Piras, Alessandro Cherubini, Mario Barilani, Erica Dugnani, Francesca Salanitro, Till Moreth, Francesco Pampaloni, Lorenzo Piemonti and Lorenza Lazzari

    Citation: Stem Cell Research & Therapy 2020 11:94

    Content type: Research

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  41. The capacity of organoids to generate complex 3D structures resembling organs is revolutionizing the fields of developmental and stem cell biology. We are currently establishing the foundations for translation...

    Authors: Joaquim Vives and Laura Batlle-Morera

    Citation: Stem Cell Research & Therapy 2020 11:72

    Content type: Commentary

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  42. Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder of unknown etiology, but is closely associated with damage to dopaminergic neurons. MSA progression is rapid. Hence, long-term drug treatm...

    Authors: Kyung-Ran Park, Chul Ju Hwang, Hyung-Mun Yun, In Jun Yeo, Dong-Young Choi, Pil-Hoon Park, Hyung Sook Kim, Jung Tae Lee, Young Suk Jung, Sang-Bae Han and Jin Tae Hong

    Citation: Stem Cell Research & Therapy 2020 11:63

    Content type: Research

    Published on:

  43. The efficiency and quality of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are crucial for regenerative medicine, disease modeling, drug screening, and the study of the development ev...

    Authors: Xiaowei Zhu, Suling Ding, Hui Li, Zhiwei Zhang, Lili Xu, Jian Wu, Xiangfei Wang, Yunzeng Zou, Xiangdong Yang and Junbo Ge

    Citation: Stem Cell Research & Therapy 2020 11:27

    Content type: Research

    Published on:

  44. To determine the impact of donor age on the therapeutic effect of bone marrow-derived mesenchymal stem cells (BMSCs) in treating adverse remodeling as the result of right ventricle (RV) pressure overload.

    Authors: Rong Liufu, Guocheng Shi, Xiaomin He, Jingjing Lv, Wei Liu, Fang Zhu, Chen Wen, Zhongqun Zhu and Huiwen Chen

    Citation: Stem Cell Research & Therapy 2020 11:96

    Content type: Research

    Published on:

  45. Chondrogenic progenitor cells (CPCs) have high self-renewal capacity and chondrogenic potential. Intra-articular delivery of purified mesenchymal stem cells (MSCs) from MRL/MpJ “superhealer” mice increased bon...

    Authors: Rikang Wang, Wei Jiang, Lang Zhang, Saisai Xie, Shuai Zhang, Shun Yuan, Yi Jin and Guangqian Zhou

    Citation: Stem Cell Research & Therapy 2020 11:93

    Content type: Research

    Published on:

  46. As the population ages, an increasing number of postmenopausal women are donors of adipose stromal cells (ASCs) and may benefit from autologous ASC-related treatments. However, the effect of menopausal status ...

    Authors: Yun Xie, Bin Fang, Wenhui Liu, Guangshuai Li, Ru-Lin Huang, Lu Zhang, Jiahao He, Shuangbai Zhou, Kai Liu and Qingfeng Li

    Citation: Stem Cell Research & Therapy 2020 11:92

    Content type: Research

    Published on:

  47. Mesenchymal stem cells (MSCs) exert immunomodulatory functions by inducing the development and differentiation of naive T cells into T cells with an anti-inflammatory regulatory T cell (Treg) phenotype. Our pr...

    Authors: Qi-Hong Chen, Fei Wu, Lei Liu, Han-bing Chen, Rui-Qiang Zheng, Hua-Ling Wang and Li-Na Yu

    Citation: Stem Cell Research & Therapy 2020 11:91

    Content type: Research

    Published on:

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