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Research
Human induced pluripotent stem cells (iPSCs) have been verified as a powerful cell model for the study of pathogenesis in hereditary disease. Autosomal dominant polycystic kidney disease (ADPKD) is caused by m...
Stem Cell Research & Therapy 2017 8:196
Published on: 19 September 2017
Short report
The paracrine effect is likely the major mechanism of the adipose-derived stem cell (ASC)-mediated cardioprotective effect. However, the exact composition and nature of ASC-released paracrine factors remain el...
Stem Cell Research & Therapy 2017 8:195
Published on: 19 September 2017
Review
Over the past years, vascular diseases have continued to threaten human health and increase financial burdens worldwide. Transplantation of allogeneic and autologous blood vessels is the most convenient treatm...
Stem Cell Research & Therapy 2017 8:194
Published on: 15 September 2017
Research
Transplantation of mesenchymal stem cells (MSC) has been proposed to improve wound healing. However, as these cells only transiently survive in the implantation site, the mechanisms underlying this beneficial ...
Stem Cell Research & Therapy 2017 8:193
Published on: 5 September 2017
Research
Chronic pancreatitis has surgical options including total pancreatectomy to control pain. To avoid surgical diabetes, the explanted pancreas can have islets harvested and transplanted. Immediately following to...
Stem Cell Research & Therapy 2017 8:192
Published on: 30 August 2017
Review
Stem cells have demonstrated encouraging potential as reparative therapy for patients suffering from post-stroke disability. Reperfusion interventions in the acute phase of stroke have shown significant benefi...
Stem Cell Research & Therapy 2017 8:191
Published on: 30 August 2017
Research
Mesenchymal stromal cells (MSCs) are currently being evaluated in numerous pre-clinical and clinical cell-based therapy studies. Furthermore, there is an increasing interest in exploring alternative uses of th...
Stem Cell Research & Therapy 2017 8:190
Published on: 25 August 2017
Research
Lineage commitment of mesenchymal stem cells (MSCs) to cardiac differentiation is controlled by transcription factors that are regulated by epigenetic events, mainly histone deacetylation and promoter DNA meth...
Stem Cell Research & Therapy 2017 8:185
Published on: 14 August 2017
Research
Mesenchymal stem cell therapy for osteoarthritis (OA) has been widely investigated, but the mechanisms are still unclear. Exosomes that serve as carriers of genetic information have been implicated in many dis...
Stem Cell Research & Therapy 2017 8:189
Published on: 14 August 2017
Research
Chemotherapy-induced premature ovarian failure (POF) is a severe complication affecting tumor patients at a childbearing age. Mesenchymal stem cells (MSCs) can partially restore the ovarian structure and funct...
Stem Cell Research & Therapy 2017 8:187
Published on: 14 August 2017
Research
Human adipose-derived stem cells (hASCs) are multipotent progenitor cells with self-renewal capabilities and multilineage differentiation potential, including osteogenesis. Although protein deubiquitinases hav...
Stem Cell Research & Therapy 2017 8:186
Published on: 14 August 2017
Research
Due to limitations of current angiogenesis assays, we aimed to develop a novel application of the rat aortic ring assay to assess the angiogenic potential of mesenchymal stromal cells (MSCs). First-trimester h...
Stem Cell Research & Therapy 2017 8:184
Published on: 14 August 2017
Research
Islet dysfunction and destruction are the common cause for both type 1 and type 2 diabetes mellitus (T2DM). The islets of Langerhans are highly vascularized miniorgans, and preserving the structural integrity ...
Stem Cell Research & Therapy 2017 8:188
Published on: 14 August 2017
Research
Although they are expandable in vitro, hepatic progenitors are immature cells and share many immunomarkers with hepatocellular carcinoma, raising potential concerns regarding maltransformation after transplant...
Stem Cell Research & Therapy 2017 8:183
Published on: 14 August 2017
Research
A hypoxic-preconditioned secretome from stem cells reportedly promotes the functional and regenerative capacity of the liver more effectively than a control secretome. However, the optimum oxygen partial press...
Stem Cell Research & Therapy 2017 8:181
Published on: 3 August 2017
Research
Neovascularization is impaired in diabetes mellitus, which leads to the development of peripheral arterial disease and is mainly attributed to the dysfunction of endothelial progenitor cells (EPCs). Previous s...
Stem Cell Research & Therapy 2017 8:182
Published on: 3 August 2017
Research
Surfactant therapy has become the standard of care for preterm infants with respiratory distress syndrome. Preclinical studies have reported the therapeutic benefits of mesenchymal stem cells (MSCs) in experim...
Stem Cell Research & Therapy 2017 8:180
Published on: 3 August 2017
Research
Acquired aplastic anemia (AA) is characterized by deficiency or dysfunction of the bone marrow (BM) microenvironment. However, little is known about the impairment of BM-derived mesenchymal stem cells (MSCs) i...
Stem Cell Research & Therapy 2017 8:178
Published on: 1 August 2017
Research
Chronic periodontal disease is an infectious disease consisting of prolonged inflammation of the supporting tooth tissue and resulting in bone loss. Guided bone regeneration procedures have become common and s...
Stem Cell Research & Therapy 2017 8:179
Published on: 1 August 2017
Research
Many reports have shown that various kinds of stem cells have the ability to recover premature ovarian aging (POA) function. Transplantation of human amniotic epithelial cells (hAECs) improves ovarian function...
Stem Cell Research & Therapy 2017 8:173
Published on: 27 July 2017
Research
Argininosuccinate synthase (ASS)1 is a urea cycle enzyme that catalyzes the conversion of citrulline and aspartate to argininosuccinate. Mutations in the ASS1 gene cause citrullinemia type I, a rare autosomal ...
Stem Cell Research & Therapy 2017 8:176
Published on: 27 July 2017
Research
Dental pulp represents an easily accessible autologous source of adult stem cells. A subset of these cells, named dental pulp pluripotent-like stem cells (DPPSC), shows high plasticity and can undergo multiple...
Stem Cell Research & Therapy 2017 8:175
Published on: 27 July 2017
Research
Human adult stem cells hold the potential for the cure of numerous conditions and degenerative diseases. They possess major advantages over pluripotent stem cells as they can be derived from donors at any age,...
Stem Cell Research & Therapy 2017 8:174
Published on: 27 July 2017
Research
Mesenchymal stem cells in tumor microenvironment can influence therapeutic responses in various types of cancers. For triple negative breast cancer, chemotherapy remains the mainstay of standard treatment. Our...
Stem Cell Research & Therapy 2017 8:177
Published on: 27 July 2017
Research
Transplantation of insulin-producing cells is considered an important diabetes therapy. Many research studies have shown that insulin-producing cells can be derived from the in-vitro cultured pancreatic coloni...
Stem Cell Research & Therapy 2017 8:172
Published on: 26 July 2017
