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Stem Cell Research & Therapy


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  1. Content type: Research

    Mesenchymal stem cells (MSCs) are one of the most promising candidates for the treatment of major neurological disorders. Desirable therapeutic properties of MSCs include reparative and regenerative potential ...

    Authors: Elena Redondo-Castro, Catriona J. Cunningham, Jonjo Miller, Helena Brown, Stuart M. Allan and Emmanuel Pinteaux

    Citation: Stem Cell Research & Therapy 2018 9:11

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  2. Content type: Research

    Mesenchymal stromal cells (MSC) are a heterogeneous population of multipotent progenitors used in the clinic because of their immunomodulatory properties and their ability to differentiate into multiple mesode...

    Authors: Eliana Amati, Omar Perbellini, Gianluca Rotta, Martina Bernardi, Katia Chieregato, Sabrina Sella, Francesco Rodeghiero, Marco Ruggeri and Giuseppe Astori

    Citation: Stem Cell Research & Therapy 2018 9:10

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  3. Content type: Research

    Recent studies have shown that autophagy plays a central role in mesenchymal stem cells (MSCs), and many studies have shown that human umbilical cord MSCs (huMSCs) can treat Alzheimer’s disease (AD) through a ...

    Authors: Wen Li, Kai Li, Jing Gao and Zhuo Yang

    Citation: Stem Cell Research & Therapy 2018 9:9

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  4. Content type: Research

    Renal fibrosis is characterized by infiltration of interstitial inflammatory cells and release of inflammatory mediators, activation and proliferation of fibroblasts, and deposition of excessive extracellular ...

    Authors: Bo Liu, Fengxia Ding, Dong Hu, Yu Zhou, Chunlan Long, Lianju Shen, Yuanyuan Zhang, Deying Zhang and Guanghui Wei

    Citation: Stem Cell Research & Therapy 2018 9:7

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  5. Content type: Research

    Patients with a deep burn injury are characterized by losing the function of perspiration and being unable to regenerate the sweat glands. Because of their easy accession, multipotency, and lower immunogenicit...

    Authors: Sujing Sun, Jun Xiao, Jiahui Huo, Zhijun Geng, Kui Ma, Xiaoyan Sun and Xiaobing Fu

    Citation: Stem Cell Research & Therapy 2018 9:8

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  6. Content type: Research

    Senescent cells are undesirable in cell therapy products due to reduced therapeutic activity and risk of aberrant cellular effects, and methods for assessing senescence are needed. Early-passage mesenchymal st...

    Authors: S. Oja, P. Komulainen, A. Penttilä, J. Nystedt and M. Korhonen

    Citation: Stem Cell Research & Therapy 2018 9:6

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  7. Content type: Research

    Acute liver failure (ALF) is a life-threatening disease with a high mortality rate. However, there are limited treatments or devices available for ALF therapy. Here, we aimed to develop a new strategy for ALF ...

    Authors: Yun-Zhong Nie, Yun-Wen Zheng, Miyuki Ogawa, Etsuko Miyagi and Hideki Taniguchi

    Citation: Stem Cell Research & Therapy 2018 9:5

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  8. Content type: Short report

    Mesenchymal stem cell therapy is a promising treatment for perianal Crohn’s fistulas refractory to conventional therapy, which are an extremely morbid complication and a true therapeutic challenge. Autologous ...

    Authors: Cécile Philandrianos, Mélanie Serrero, Fanny Grimaud, Jérémy Magalon, Carine Visée, Mélanie Velier, Pauline Francois, Pierre Orsoni, Guy Magalon, Jean-Charles Grimaud, Ariadne Desjeux, Julie Véran and Florence Sabatier

    Citation: Stem Cell Research & Therapy 2018 9:4

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  9. Content type: Research

    Pluripotent stem cells hold great promise for regenerative medicine. However, before clinical application, reproducible protocols for pluripotent stem cell differentiation should be established. Extracellular ...

    Authors: Yang Yu, Xiaoxiao Wang, Xiaoxin Zhang, Yanhua Zhai, Xukun Lu, Haixia Ma, Kai Zhu, Tongbiao Zhao, Jianwei Jiao, Zhen-Ao Zhao and Lei Li

    Citation: Stem Cell Research & Therapy 2018 9:2

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  10. Content type: Research

    Bone marrow mesenchymal stem cells (MSCs) are promising candidates for the treatment of various inflammatory disorders due to their profound immunomodulatory properties. However, the immunosuppressive capacity...

    Authors: Binsheng Wang, Yu Lin, Yongxian Hu, Wei Shan, Senquan Liu, Yulin Xu, Hao Zhang, Shuyang Cai, Xiaohong Yu, Zhen Cai and He Huang

    Citation: Stem Cell Research & Therapy 2017 8:292

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  11. Content type: Research

    Human pluripotent stem cells (hPSCs) provide a promising cell source for ocular cell replacement therapy, but often lack standardized and xenogeneic-free culture and differentiation protocols. We aimed to deve...

    Authors: Heidi Hongisto, Tanja Ilmarinen, Meri Vattulainen, Alexandra Mikhailova and Heli Skottman

    Citation: Stem Cell Research & Therapy 2017 8:291

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  12. Content type: Research

    Sepsis is a severe medical condition that ranks among the top 10 causes of death worldwide and which has permanently high incidence rates. Mesenchymal stem cells (MSCs) have been found to be potent modulators ...

    Authors: Leonardo Pedrazza, Monica Cubillos-Rojas, Fernanda Cristina de Mesquita, Carolina Luft, Aline Andrea Cunha, Jose Luis Rosa and Jarbas Rodrigues de Oliveira

    Citation: Stem Cell Research & Therapy 2017 8:289

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  13. Content type: Research

    Retinal degeneration (RD) is a leading cause of irreversible blindness, affecting millions of people worldwide. Stem cell transplantation has been considered a promising therapy for retinal degenerative diseas...

    Authors: Li Huang, Zongyi Li, Haibin Tian, Weiguo Wang, Dawei Cui, Zhe Zhou, Xiao Chen, Herman S. Cheung, Guo-tong Xu and Yu Chen

    Citation: Stem Cell Research & Therapy 2017 8:290

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  14. Content type: Review

    Autologous and allogeneic adult mesenchymal stem/stromal cells (MSCs) are increasingly being investigated for treating a wide range of clinical diseases. Allogeneic MSCs are especially attractive due to their ...

    Authors: Alix K. Berglund, Lisa A. Fortier, Douglas F. Antczak and Lauren V. Schnabel

    Citation: Stem Cell Research & Therapy 2017 8:288

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  15. Content type: Research

    Corneal endothelial dysfunction causes severe impairment of vision. The only solution is corneal transplantation. However, this treatment is hampered by a worldwide shortage of donor corneas. New therapies may...

    Authors: Peng Sun, Lin Shen, Canwei Zhang, Liqun Du and Xinyi Wu

    Citation: Stem Cell Research & Therapy 2017 8:287

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  16. Content type: Research

    Human amnion-derived mesenchymal stem cells (hAD-MSCs) have the features of mesenchymal stem cells (MSCs). Low-intensity pulsed ultrasound (LIPUS) can promote the expression of various growth factors and anti-...

    Authors: Li Ling, Xiushan Feng, Tianqin Wei, Yan Wang, Yaping Wang, Wenqian Zhang, Lianli He, Ziling Wang, Qianru Zeng and Zhengai Xiong

    Citation: Stem Cell Research & Therapy 2017 8:283

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  17. Content type: Research

    Type 2 diabetes (T2D) is closely associated with liver fibrosis, but no effective treatments are currently available. This study was designed to investigate the therapeutic effects of ADSCs on insulin resistan...

    Authors: Naishun Liao, Youshi Zheng, Haihua Xie, Bixing Zhao, Yongyi Zeng, Xiaolong Liu and Jingfeng Liu

    Citation: Stem Cell Research & Therapy 2017 8:286

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  18. Content type: Research

    Mesenchymal stem cells (MSCs) hold great promise for cartilage repair given their relative abundance, ease of isolation, and chondrogenic potential. To enhance MSC chondrogenesis, extracellular matrix componen...

    Authors: Tianyi Wang and Fan Yang

    Citation: Stem Cell Research & Therapy 2017 8:284

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  19. Content type: Short report

    Epidermal grafting using cells derived from pluripotent stem cells will change the face of this side of regenerative cutaneous medicine. To date, the safety of the graft would be the major unmet deal in order ...

    Authors: Sophie Domingues, Yolande Masson, Aurore Marteyn, Jennifer Allouche, Anselme L. Perrier, Marc Peschanski, Cecile Martinat, Christine Baldeschi and Gilles Lemaître

    Citation: Stem Cell Research & Therapy 2017 8:285

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  20. Content type: Research

    Strontium is a widely used anti-osteoporotic agent due to its dual effects on inhibiting bone resorption and stimulating bone formation. Thus, we studied the dose response of strontium on osteo-inductive effic...

    Authors: Abudousaimi Aimaiti, Asihaerjiang Maimaitiyiming, Xu Boyong, Kaisaier Aji, Cao Li and Lei Cui

    Citation: Stem Cell Research & Therapy 2017 8:282

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  21. Content type: Research

    Although previous reports have revealed the therapeutic potential of stem cell transplantation in diabetic polyneuropathy, the effects of cell transplantation on long-term diabetic polyneuropathy have not been...

    Authors: Maiko Omi, Masaki Hata, Nobuhisa Nakamura, Megumi Miyabe, Shogo Ozawa, Hitoshi Nukada, Masami Tsukamoto, Kazunori Sango, Tatsuhito Himeno, Hideki Kamiya, Jiro Nakamura, Jun Takebe, Tatsuaki Matsubara and Keiko Naruse

    Citation: Stem Cell Research & Therapy 2017 8:279

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  22. Content type: Research

    The stiffness of the myocardial extracellular matrix (ECM) and the transplanted cell type are vitally important in promoting angiogenesis. However, the combined effect of the two factors remains uncertain. The...

    Authors: Shuning Zhang, Xin Ma, Junjie Guo, Kang Yao, Cong Wang, Zhen Dong, Hong Zhu, Fan Fan, Zheyong Huang, Xiangdong Yang, Juying Qian, Yunzeng Zou, Aijun Sun and Junbo Ge

    Citation: Stem Cell Research & Therapy 2017 8:280

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  23. Content type: Research

    Low-intensity pulsed ultrasound (LIPUS) is a mechanical stimulus that plays a key role in regulating the differentiation of bone marrow mesenchymal stem cells (BMSCs). However, the way in which it affects the ...

    Authors: Peng Xia, Xiaoju Wang, Yanping Qu, Qiang Lin, Kai Cheng, Mingxia Gao, Shasha Ren, Tingting Zhang and Xueping Li

    Citation: Stem Cell Research & Therapy 2017 8:281

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