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  1. Patients with severe acute pancreatitis (SAP), which is characterized by high morbidity and mortality, account for an increasing medical burden worldwide. We previously found that mesenchymal stem cells (MSCs)...

    Authors: Guodong Song, Jia Zhou, Ruimei Song, Dalu Liu, Weidi Yu, Wangcheng Xie, Zhilong Ma, Jian Gong, Hongbo Meng, Tingsong Yang and Zhenshun Song

    Citation: Stem Cell Research & Therapy 2020 11:420

    Content type: Research

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  2. Stem cell therapy is becoming an emerging therapeutic option for chronic liver disease (CLD). However, whether stem cell therapy is more effective than conventional treatment remains questionable. We performed...

    Authors: Guang-Peng Zhou, Yi-Zhou Jiang, Li-Ying Sun and Zhi-Jun Zhu

    Citation: Stem Cell Research & Therapy 2020 11:419

    Content type: Research

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  3. Immune system disorders play important roles in acute lung injury (ALI), and mesenchymal stem cell (MSC) treatment can reduce inflammation during ALI. In this study, we compared the changes in lung B cells dur...

    Authors: Bing Feng, Jiaqi Zhu, Yanping Xu, Wenyi Chen, Xinyu Sheng, Xudong Feng, Xiaowei Shi, Jingqi Liu, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Lanjuan Li and Hongcui Cao

    Citation: Stem Cell Research & Therapy 2020 11:418

    Content type: Research

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  4. Millions suffer from skin diseases. Functional interfollicular epidermal stem cells are needed in skin therapy or drug screening in vitro. We obtained functional interfollicular epidermal stem cells with intac...

    Authors: Ling Leng, Jie Ma, Luye Lv, Wenjuan Wang, Dunqin Gao, Yunping Zhu and Zhihong Wu

    Citation: Stem Cell Research & Therapy 2020 11:415

    Content type: Short report

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  5. The therapeutic role of mesenchymal stem cells (MSCs) has been widely confirmed in several animal models of premature infant diseases. Micromolecule peptides have shown promise for the treatment of premature i...

    Authors: Yu Wang, Lin Zhang, Yun Wu, Rongping Zhu, Yan Wang, Yan Cao, Wei Long, Chenbo Ji, Huaiyan Wang and Lianghui You

    Citation: Stem Cell Research & Therapy 2020 11:414

    Content type: Research

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  6. Ischaemic stroke has become the main cause of death and severe neurological disorders, for which effective restorative treatments are currently limited. While stem cell transplantation offers therapeutic poten...

    Authors: Xuemei Zhang, Hao Tang, Senlin Mao, Bing Li, Yinglian Zhou, Hui Yue, Duo Wang, Yifei Wang and Jin Fu

    Citation: Stem Cell Research & Therapy 2020 11:413

    Content type: Research

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  7. Cell therapy is one of the most promising therapeutic interventions for retinitis pigmentosa. In the current study, we aimed to assess if peripheral blood-derived monocytes which are highly abundant and access...

    Authors: Alaknanda Mishra, K. Varsha Mohan, Perumal Nagarajan, Srikanth Iyer, Ashwani Kesarwani, Madhu Nath, Laxmi Moksha, Jashdeep Bhattacharjee, Barun Das, Kshama Jain, Parul Sahu, Prakriti Sinha, T. Velapandian and Pramod Upadhyay

    Citation: Stem Cell Research & Therapy 2020 11:412

    Content type: Research

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  8. Retinal pigment epithelium (RPE) replacement has been proposed as an efficacious treatment for age-related macular degeneration (AMD), which is the primary cause of vision loss in the elderly worldwide. The em...

    Authors: Jiahui Liu, Liu Yang, Xiaoran Wang, Shoubi Wang, Zheqian Huang, Chaoyang Li, Ying Liu, Yaqi Cheng, Chengxiu Liu and Zhichong Wang

    Citation: Stem Cell Research & Therapy 2020 11:411

    Content type: Research

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  9. Acute kidney injury (AKI) is a common clinical disease with complex pathophysiology and limited therapeutic choices. This prompts the need for novel therapy targeting multiple aspects of this disease. Human am...

    Authors: Yifei Ren, Ying Chen, Xizi Zheng, Hui Wang, Xin Kang, Jiawei Tang, Lei Qu, Xiaoyan Shao, Suxia Wang, Shuangling Li, Gang Liu and Li Yang

    Citation: Stem Cell Research & Therapy 2020 11:410

    Content type: Research

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  10. Endothelial cells (ECs) are essential regulators of the vasculature, lining arteries, veins, and capillary beds. While all ECs share a number of structural and molecular features, heterogeneity exists dependin...

    Authors: Kelly Mulfaul, Joseph C. Giacalone, Andrew P. Voigt, Megan J. Riker, Dalyz Ochoa, Ian C. Han, Edwin M. Stone, Robert F. Mullins and Budd A. Tucker

    Citation: Stem Cell Research & Therapy 2020 11:409

    Content type: Method

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  11. This study is designed to generate and propagate human spermatogonial stem cells (SSCs) derived from human pluripotent stem cells (hPSCs).

    Authors: Huiming Xu, Mengbo Yang, Ruhui Tian, Yonghui Wang, Linhong Liu, Zijue Zhu, Shi Yang, Qingqing Yuan, Minghui Niu, Chencheng Yao, Erlei Zhi, Peng Li, Chenhao Zhou, Zuping He, Zheng Li and Wei-Qiang Gao

    Citation: Stem Cell Research & Therapy 2020 11:408

    Content type: Research

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  12. Human platelet lysate (HPL) is emerging as the preferred xeno-free supplement for the expansion of mesenchymal stromal cells (MSCs) for bone tissue engineering (BTE) applications. Due to a growing demand, the ...

    Authors: Siddharth Shanbhag, Samih Mohamed-Ahmed, Turid Helen Felli Lunde, Salwa Suliman, Anne Isine Bolstad, Tor Hervig and Kamal Mustafa

    Citation: Stem Cell Research & Therapy 2020 11:351

    Content type: Research

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  13. In recent years, significant progress has been made in developing highly complex tissue-engineered skin substitutes (TESSs) for wound healing. However, the lack of skin appendages, such as hair follicles and s...

    Authors: Qun Zhang, Jie Wen, Chang Liu, Chuan Ma, Fuxiang Bai, Xue Leng, Zhihong Chen, Zhiwei Xie, Jun Mi and Xunwei Wu

    Citation: Stem Cell Research & Therapy 2020 11:407

    Content type: Research

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  14. A major challenge for the clinical use of human pluripotent stem cells is the development of safe, robust and controlled differentiation protocols. Adaptation of research protocols using reagents designated as...

    Authors: Loriana Vitillo, Catherine Durance, Zoe Hewitt, Harry Moore, Austin Smith and Ludovic Vallier

    Citation: Stem Cell Research & Therapy 2020 11:406

    Content type: Research

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  15. The aim of this study was to examine the effect of a three-step approach that utilizes the application of adipose tissue-derived mesenchymal stem cells (AD-MSCs), encapsulation, and pulsed focused ultrasound (...

    Authors: Mehdi Razavi, Tanchen Ren, Fengyang Zheng, Arsenii Telichko, Jing Wang, Jeremy J. Dahl, Utkan Demirci and Avnesh S. Thakor

    Citation: Stem Cell Research & Therapy 2020 11:405

    Content type: Research

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  16. Tendon stem cells (TSCs) have been reported to hold promises for tendon repair and regeneration. However, less is known about the effects of exosomes derived from TSCs. Therefore, we aimed to clarify the heali...

    Authors: Mingzhao Zhang, Hengchen Liu, Qingbo Cui, Peilin Han, Shulong Yang, Manyu Shi, Tingting Zhang, Zenan Zhang and Zhaozhu Li

    Citation: Stem Cell Research & Therapy 2020 11:402

    Content type: Research

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  17. Globally, 1 in 11 adults have diabetes mellitus, and 90% of the cases are type 2 diabetes mellitus. Insulin resistance is a central defect in type 2 diabetes mellitus, and although multiple drugs have been dev...

    Authors: Guang Chen, Xiao-yan Fan, Xiao-peng Zheng, Yue-lei Jin, Ying Liu and Shuang-chun Liu

    Citation: Stem Cell Research & Therapy 2020 11:401

    Content type: Research

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  18. Asthma is a chronic inflammatory disease associated with airway hyper-responsiveness, chronic inflammatory response, and excessive structural remodeling. The current therapeutic strategies in asthmatic patient...

    Authors: Fatemeh Mirershadi, Mahdi Ahmadi, Aysa Rezabakhsh, Hadi Rajabi, Reza Rahbarghazi and Rana Keyhanmanesh

    Citation: Stem Cell Research & Therapy 2020 11:400

    Content type: Review

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  19. Lung disease is a leading cause of morbidity and mortality. A breach in the lung alveolar-epithelial barrier and impairment in lung function are hallmarks of acute and chronic pulmonary illness. This review is...

    Authors: Alvaro Moreira, Rija Naqvi, Kristen Hall, Chimobi Emukah, John Martinez, Axel Moreira, Evan Dittmar, Sarah Zoretic, Mary Evans, Delanie Moses and Shamimunisa Mustafa

    Citation: Stem Cell Research & Therapy 2020 11:399

    Content type: Review

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  20. Acute kidney injury (AKI) is characterized by rapid failure of renal function and has no curative therapies. Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) are known to carry therapeutic f...

    Authors: Mujib Ullah, Daniel D. Liu, Sravanthi Rai, Mehdi Razavi, Waldo Concepcion and Avnesh S. Thakor

    Citation: Stem Cell Research & Therapy 2020 11:398

    Content type: Research

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  21. Regenerative medicine plays a major role in biomedicine, and given the ever-expanding boundaries of this knowledge, numerous ethical considerations have been raised.

    Authors: Leila Afshar, Hamid-Reza Aghayan, Jila Sadighi, Babak Arjmand, Seyed-Mahmoud Hashemi, Mohsen Basiri, Reza Omani Samani, Mohammad Kazemi Ashtiani, Seyed-Ali Azin, Ensiyeh Hajizadeh-Saffar, Ehsan Shamsi Gooshki, Amir-Ali Hamidieh, Mohammad-Reza Rezania Moallem, Seyed-Mohammad Azin, Sadegh Shariatinasab, Mehdi Soleymani-Goloujeh…

    Citation: Stem Cell Research & Therapy 2020 11:396

    Content type: Commentary

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  22. Diabetic foot is one of the severest complications of diabetes. In severe cases, this disease may be lead to amputation or even death due to secondary infection and ischemic necrosis. Since the ineffectiveness...

    Authors: Xiansheng Zhao, Jiamin Guo, Fangfang Zhang, Jue Zhang, Delin Liu, Wenjun Hu, Han Yin and Liang Jin

    Citation: Stem Cell Research & Therapy 2020 11:394

    Content type: Review

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  23. Hepatocyte-like cells (HLCs) derived from human induced pluripotent stem cells (iPSCs) hold great promise in toxicological applications as well as in regenerative medicine. Previous efforts on hepatocyte diffe...

    Authors: Xiugong Gao, Rong Li, Patrick Cahan, Yang Zhao, Jeffrey J. Yourick and Robert L. Sprando

    Citation: Stem Cell Research & Therapy 2020 11:393

    Content type: Research

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  24. Human bone marrow-derived mesenchymal stem cells (hBMSCs) have chondrocyte differentiation potential and are considered to be a cell source for cell-transplantation-mediated repair of cartilage defects, includ...

    Authors: Shuang Lv, Jinying Xu, Lin Chen, Haitao Wu, Wei Feng, Yangyang Zheng, Pengdong Li, Haiying Zhang, Lihong Zhang, Guangfan Chi and Yulin Li

    Citation: Stem Cell Research & Therapy 2020 11:392

    Content type: Research

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  25. Mesenchymal stem cells (MSCs) serve as an attractive vehicle for cell-directed enzyme prodrug therapy (CDEPT) due to their unique tumour-nesting ability. Such approach holds high therapeutic potential for trea...

    Authors: Geraldine Xue En Tu, Yoon Khei Ho, Zhi Xu Ng, Ke Jia Teo, Tseng Tsai Yeo and Heng-Phon Too

    Citation: Stem Cell Research & Therapy 2020 11:391

    Content type: Research

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  26. β-Thalassemias represent a group of genetic disorders caused by human hemoglobin beta (HBB) gene mutations. The radical curative approach is to correct the mutations causing the disease. CRISPR-CAS9 is a novel ge...

    Authors: Hala Gabr, Mona Kamal El Ghamrawy, Abdulrahman H. Almaeen, Ahmed Samir Abdelhafiz, Aya Osama Saad Hassan and Maha Hamdi El Sissy

    Citation: Stem Cell Research & Therapy 2020 11:390

    Content type: Research

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  27. Cell therapy has been evaluated pre-clinically and clinically as a means to improve wound vascularization and healing. While translation of this approach to clinical practice ideally requires the availability ...

    Authors: Bart Vaes, Ellen Van Houtven, Ellen Caluwé and Aernout Luttun

    Citation: Stem Cell Research & Therapy 2020 11:389

    Content type: Research

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  28. Embryonic stem cells (ESCs) derived from somatic cell nuclear transfer (SCNT) and induced pluripotent stem cells (iPSCs) are promising tools for meeting the personalized requirements of regenerative medicine. ...

    Authors: Zhi-ping Zhang, Jun-tao Zhang, Shu-cheng Huang, Xiu-yuan He and Li-xin Deng

    Citation: Stem Cell Research & Therapy 2020 11:388

    Content type: Review

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  29. It is difficult to immediately use mesenchymal stem cells (MSCs) for the patient with rotator cuff disease because isolation and culture time are required. Thus, the MSCs would be prepared in advanced in cryop...

    Authors: Ji-Hye Yea, Jin-Kyung Park, In Ja Kim, Gayoung Sym, Tae-Soo Bae and Chris Hyunchul Jo

    Citation: Stem Cell Research & Therapy 2020 11:387

    Content type: Research

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  30. The basic pathological changes of primary ovarian insufficiency (POI) include ovarian tissue fibrosis and follicular development disorders. The human umbilical cord mesenchymal stem cell (hUMSC) transplantatio...

    Authors: Linlu Cui, Hongchu Bao, Zhongfeng Liu, Xuejing Man, Hongyuan Liu, Yun Hou, Qianqian Luo, Siyuan Wang, Qiang Fu and Hongqin Zhang

    Citation: Stem Cell Research & Therapy 2020 11:386

    Content type: Research

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  31. Local anesthetics (LAs) are widely used to control pain during various clinical treatments. One of the side effects of LAs, cytotoxicity, has been investigated in various cells including stem/progenitor cells....

    Authors: Young Hoon Kim, Ga Young Park, Nechama Rabinovitch, Solaiman Tarafder and Chang H. Lee

    Citation: Stem Cell Research & Therapy 2020 11:385

    Content type: Research

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  32. We hypothesized that adipose-derived mesenchymal stem cells (ADMSCs) may ameliorate sepsis-induced acute lung injury (ALI) and change microorganism populations in the gut microbiota, such as that of Firmicutes...

    Authors: Junyi Sun, Xianfei Ding, Shaohua Liu, Xiaoguang Duan, Huoyan Liang and Tongwen Sun

    Citation: Stem Cell Research & Therapy 2020 11:384

    Content type: Research

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  33. Stem cell therapies have gained great attention for providing novel solutions for treatment of various injuries and diseases due to stem cells’ self-renewal, ability to differentiate into various cell types, a...

    Authors: Wei Lin, Xiaoyang Qi, Wenjing Guo, Danyang Liang, Heting Chen, Baoping Lin and Xiaoyuan Deng

    Citation: Stem Cell Research & Therapy 2020 11:383

    Content type: Research

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  34. Mesenchymal stem cells (MSCs) can be isolated from not only bone marrow, but also various adult mesenchymal tissues such as periosteum, skeletal muscle, and adipose tissue. MSCs from different tissue sources h...

    Authors: Na Li, Jinfang Gao, Liangyu Mi, Gailian Zhang, Liyun Zhang, Na Zhang, Rongxiu Huo, Junping Hu and Ke Xu

    Citation: Stem Cell Research & Therapy 2020 11:381

    Content type: Review

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  35. The precise, functional and safe insertion of large DNA payloads into host genomes offers versatility in downstream genetic engineering-associated applications, spanning cell and gene therapies, therapeutic pr...

    Authors: Namrata Chaudhari, Amanda M. Rickard, Suki Roy, Peter Dröge and Harshyaa Makhija

    Citation: Stem Cell Research & Therapy 2020 11:380

    Content type: Research

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  36. Sepsis remains a leading cause of death in critically ill patients. It is well known that mesenchymal stem cells (MSCs) are a promising therapy partly due to their paracrine-mediated immunoregulatory function....

    Authors: Feng Liu, Jianfeng Xie, Xiwen Zhang, Zongsheng Wu, Shi Zhang, Ming Xue, Jianxiao Chen, Yi Yang and Haibo Qiu

    Citation: Stem Cell Research & Therapy 2020 11:378

    Content type: Research

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  37. Various hepatoxic factors, such as viruses, drugs, lipid deposition, and autoimmune responses, induce acute or chronic liver injury, and 3.5% of all worldwide deaths result from liver cirrhosis, liver failure,...

    Authors: Chenxia Hu, Lingfei Zhao, Lingjian Zhang, Qiongling Bao and Lanjuan Li

    Citation: Stem Cell Research & Therapy 2020 11:377

    Content type: Review

    Published on:

  38. Citation: Stem Cell Research & Therapy 2020 11:376

    Content type: Correction

    Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:31

  39. Leishmaniasis is a neglected disease caused by Leishmania spp. One of its characteristics is an imbalance of host immune responses to foster parasite survival. In this setting, mesenchymal stromal cells (MSCs) ma...

    Authors: Tadeu Diniz Ramos, Johnatas Dutra Silva, Alessandra Marcia da Fonseca-Martins, Juliana Elena da Silveira Pratti, Luan Firmino-Cruz, Diogo Maciel-Oliveira, Julio Souza Dos-Santos, João Ivo Nunes Tenorio, Almair Ferreira de Araujo, Célio Geraldo Freire-de-Lima, Bruno Lourenço Diaz, Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco and Herbert Leonel de Matos Guedes

    Citation: Stem Cell Research & Therapy 2020 11:374

    Content type: Research

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  40. Myocardial infarction (MI) is a severe disease that often associated with dysfunction of angiogenesis. Cell-based therapies for MI using mesenchymal stem cell (MSC)-derived exosomes have been well studied due ...

    Authors: Jiacheng Sun, Han Shen, Lianbo Shao, Xiaomei Teng, Yueqiu Chen, Xuan Liu, Ziying Yang and Zhenya Shen

    Citation: Stem Cell Research & Therapy 2020 11:373

    Content type: Research

    Published on:

  41. Clinically, severe burns remain one of the most challenging issues, but an ideal treatment is yet absent. Our purpose is to compare the efficacy of stem cell therapy in a preclinical model of burn wound healing.

    Authors: Hanxiao Yi, Yang Wang, Zhen Yang and Zhiqin Xie

    Citation: Stem Cell Research & Therapy 2020 11:372

    Content type: Review

    Published on:

  42. The widely recognized anti-cancer potential of aspirin has created a broad interest to explore the clinical benefits of aspirin in cancer therapy. However, the current understanding of the molecular mechanisms...

    Authors: Xiaoyuan Zhang, Renle Du, Na Luo, Rong Xiang and Wenzhi Shen

    Citation: Stem Cell Research & Therapy 2020 11:370

    Content type: Research

    Published on:

  43. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Chenhong Lin, Cinzia Calzarossa, Teresa Fernandez-Zafra, Jia Liu, Xiaofei Li, Åsa Ekblad-Nordberg, Erika Vazquez-Juarez, Simone Codeluppi, Lena Holmberg, Maria Lindskog, Per Uhlén and Elisabet Åkesson

    Citation: Stem Cell Research & Therapy 2020 11:369

    Content type: Correction

    Published on:

    The original article was published in Stem Cell Research & Therapy 2020 11:320

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