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Stem Cell Research & Therapy


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  1. Content type: Method

    Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have been widely used to generate cellular models harboring specific disease-related genotypes. Of particular importance are ESC and iPSC ...

    Authors: Meixiang Zhang, Justine Ngo, Filomena Pirozzi, Ying-Pu Sun and Anthony Wynshaw-Boris

    Citation: Stem Cell Research & Therapy 2018 9:67

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  2. Content type: Research

    Use of bioscaffolds to direct osteogenic differentiation of adult multipotent stromal cells (MSCs) without exogenous proteins is a contemporary approach to bone regeneration. Identification of in vivo osteogen...

    Authors: Wei Duan, Cong Chen, Masudul Haque, Daniel Hayes and Mandi J. Lopez

    Citation: Stem Cell Research & Therapy 2018 9:60

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  3. Content type: Research

    Shockwaves and mesenchymal stem cells (MSCs) have been widely accepted as useful tools for many orthopedic applications. However, the modulatory effects of shockwaves on MSCs remain controversial. In this stud...

    Authors: Hao Zhang, Zhong-Li Li, Fei Yang, Qiang Zhang, Xiang-Zheng Su, Ji Li, Ning Zhang, Chun-Hui Liu, Ning Mao and Heng Zhu

    Citation: Stem Cell Research & Therapy 2018 9:54

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  4. Content type: Research

    Intervertebral disc (IVD) degeneration is characterized by an early decrease in cellularity of the nucleus pulposus (NP) region, and associated extracellular matrix changes, reduced hydration, and progressive ...

    Authors: Ruhang Tang, Liufang Jing, Vincent P. Willard, Chia-lung Wu, Farshid Guilak, Jun Chen and Lori A. Setton

    Citation: Stem Cell Research & Therapy 2018 9:61

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  5. Content type: Research

    The advent of human-induced pluripotent stem cells holds great promise for producing ample individualized hepatocytes. Although previous efforts have succeeded in generating hepatocytes from human pluripotent ...

    Authors: Cong Du, Yuan Feng, Dongbo Qiu, Yan Xu, Mao Pang, Nan Cai, Andy Peng Xiang and Qi Zhang

    Citation: Stem Cell Research & Therapy 2018 9:58

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  6. Content type: Review

    Recent studies have suggested that the regulation of endogenous neural stem cells (NSCs) or transplanting of exogenous nerve cells are the newest and most promising methods for the treatment of dementia and ot...

    Authors: Chao Ren, Peiyuan Yin, Neng Ren, Zhe Wang, Jiahui Wang, Caiyi Zhang, Wei Ge, Deqin Geng and Xiaotong Wang

    Citation: Stem Cell Research & Therapy 2018 9:66

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  7. Content type: Review

    Mesenchymal stem cells (MSCs) are multipotent stem cells that have gained significant attention in the field of regenerative medicine. The differentiation potential along with paracrine properties of MSCs have...

    Authors: Somayeh Keshtkar, Negar Azarpira and Mohammad Hossein Ghahremani

    Citation: Stem Cell Research & Therapy 2018 9:63

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  8. Content type: Research

    The reciprocal fate decision of mesenchymal stem cells (MSCs) to either bone or adipocytes is determined by Wnt-related signaling and the glucagon-like peptide-1 receptor (GLP-1R). Azoramide, an ER stress alle...

    Authors: Banjun Ruan, Zheng Zhu, Zhao Yan, Wei Yang, Dongsheng Zhai, Li Wang, Zichen Ye, Huanyu Lu, An Xiang, Jingwei Liang, Yinghao Jiang, Chengming Xu, Zhenyu Wang, Ming Wei, Xiaoying Lei, Xiaorui Cao…

    Citation: Stem Cell Research & Therapy 2018 9:57

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  9. Content type: Research

    Mesenchymal stem cells (MSCs) are a reliable resource for bone regeneration and tissue engineering, but the molecular mechanisms of differentiation remain unclear. The tumor antigen 15-leucine-rich repeat cont...

    Authors: Yuejun Wang, Yunsong Liu, Min Zhang, Longwei Lv, Xiao Zhang, Ping Zhang and Yongsheng Zhou

    Citation: Stem Cell Research & Therapy 2018 9:65

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  10. Content type: Research

    Although many reports show that various kinds of stem cells have the ability to recover function in premature ovarian aging, few studies have looked at stem cell treatment of natural ovarian aging (NOA). We de...

    Authors: Chenyue Ding, Qinyan Zou, Fuxin Wang, Huihua Wu, Rulei Chen, Jinghuan Lv, Mingfa Ling, Jian Sun, Wei Wang, Hong Li and Boxian Huang

    Citation: Stem Cell Research & Therapy 2018 9:55

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  11. Content type: Research

    Circular RNAs (circRNAs) are regarded as a novel class of noncoding RNA regulators. Although a number of circRNAs have been identified by bioinformatics analysis of RNA-seq data, tissue and disease-specific ci...

    Authors: Wei Lei, Tingting Feng, Xing Fang, You Yu, Junjie Yang, Zhen-Ao Zhao, Junwei Liu, Zhenya Shen, Wenbo Deng and Shijun Hu

    Citation: Stem Cell Research & Therapy 2018 9:56

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  12. Content type: Research

    Scarring is the product of natural restoration, yet its treatment remains challenging. Both collagen and fibroblasts are abnormally abundant in scars, leading to scar hyperplasia or contracture. Several clinic...

    Authors: Xiao Xu, Linying Lai, Xuyi Zhang, Jinhong Chen, Junnan Chen, Fei Wang, Jingchen Zheng and Minliang Chen

    Citation: Stem Cell Research & Therapy 2018 9:64

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  13. Content type: Research

    Mesenchymal stem cells derived from gingiva (GMSCs) display profound immunomodulation properties in addition to self-renewal and multilineage differentiation capacities. Hydrogen sulfide (H2S) is not only an envi...

    Authors: Ruili Yang, Tingting Yu, Dawei Liu, Songtao Shi and Yanheng Zhou

    Citation: Stem Cell Research & Therapy 2018 9:62

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  14. Content type: Research

    Adipose-derived stem cells (ADSCs) are an attractive cell source for bone tissue engineering and have great potential for bone regeneration and defect repair. The transcriptional coactivator with PDZ-binding m...

    Authors: Yumin Zhu, Yaping Wu, Jie Cheng, Qiong Wang, Zhongwu Li, Yanling Wang, Dongmiao Wang, Hua Wang, Weibing Zhang, Jinhai Ye, Hongbing Jiang and Lin Wang

    Citation: Stem Cell Research & Therapy 2018 9:53

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  15. Content type: Research

    Human mesenchymal stem cell (hMSC) differentiation into osteoblasts has important clinical significance in treating bone injury, and the stiffness of the extracellular matrix (ECM) has been shown to be an impo...

    Authors: Meiyu Sun, Guangfan Chi, Juanjuan Xu, Ye Tan, Jiayi Xu, Shuang Lv, Ziran Xu, Yuhan Xia, Lisha Li and Yulin Li

    Citation: Stem Cell Research & Therapy 2018 9:52

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  16. Content type: Research

    Thalassemia is the most common genetic disease worldwide; those with severe disease require lifelong blood transfusion and iron chelation therapy. The definitive cure for thalassemia is allogeneic hematopoieti...

    Authors: Methichit Wattanapanitch, Nattaya Damkham, Ponthip Potirat, Kongtana Trakarnsanga, Montira Janan, Yaowalak U-pratya, Pakpoom Kheolamai, Nuttha Klincumhom and Surapol Issaragrisil

    Citation: Stem Cell Research & Therapy 2018 9:46

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  17. Content type: Research

    The LIM-homeobox transcription factor islet-1 (ISL1) has been proposed as a marker for cardiovascular progenitor cells. This study investigated whether forced expression of ISL1 in human mesenchymal stem cells...

    Authors: Qiuling Xiang, Yan Liao, Hua Chao, Weijun Huang, Jia Liu, Haixuan Chen, Dongxi Hong, Zhengwei Zou, Andy Peng Xiang and Weiqiang Li

    Citation: Stem Cell Research & Therapy 2018 9:51

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  18. Content type: Research

    Human menstrual blood-derived stromal cells (MenSCs) are highly proliferative and show multiple differentiation capacity. The convenience and non-invasiveness make MenSC a novel cell source for regenerative me...

    Authors: Siwen Zhang, Pingping Li, Zhengwei Yuan and Jichun Tan

    Citation: Stem Cell Research & Therapy 2018 9:48

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  19. Content type: Research

    Changes in metabolic pathway preferences are key events in the reprogramming process of somatic cells to induced pluripotent stem cells (iPSCs). The optimization of metabolic conditions can enhance reprogrammi...

    Authors: Zhaoyu Lin, Fei Liu, Peiliang Shi, Anying Song, Zan Huang, Dayuan Zou, Qin Chen, Jianxin Li and Xiang Gao

    Citation: Stem Cell Research & Therapy 2018 9:47

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  20. Content type: Review

    In the past years, cardiac mortality has decreased, but cardiac diseases are still responsible for millions of deaths every year worldwide. Bone-marrow mesenchymal stem cells (BMSCs) transplantation may be a p...

    Authors: Xiaofei Guo, Yan Bai, Li Zhang, Bo Zhang, Naufal Zagidullin, Katherine Carvalho, Zhimin Du and Benzhi Cai

    Citation: Stem Cell Research & Therapy 2018 9:44

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  21. Content type: Review

    Due to their anti-inflammatory, antiapoptotic, antimicrobial, and antifibrotic properties, mesenchymal stromal cells (MSCs) have been considered a promising alternative for treatment of respiratory diseases. N...

    Authors: Luisa H. A. Silva, Mariana A. Antunes, Claudia C. Dos Santos, Daniel J. Weiss, Fernanda F. Cruz and Patricia R. M. Rocco

    Citation: Stem Cell Research & Therapy 2018 9:45

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  22. Content type: Research

    Induced pluripotent stem cells (iPS) represent an innovative source for the standardized in vitro generation of macrophages (Mφ). Mφ show great promise in disease pathogenesis, particularly tuberculosis. However,...

    Authors: Danping Hong, Jiongyan Ding, Ouyang Li, Quan He, Minxia Ke, Mengyi Zhu, Lili Liu, Wen-Bin Ou, Yulong He and Yuehong Wu

    Citation: Stem Cell Research & Therapy 2018 9:49

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  23. Content type: Research

    Asherman’s syndrome (AS) is one of the gynecological disorders caused by the destruction of the endometrium. For some cases of AS available surgical methods and hormonal therapy are ineffective. Stem cell tran...

    Authors: Alisa Domnina, Polina Novikova, Julia Obidina, Irina Fridlyanskaya, Larisa Alekseenko, Irina Kozhukharova, Olga Lyublinskaya, Valeriy Zenin and Nikolay Nikolsky

    Citation: Stem Cell Research & Therapy 2018 9:50

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  24. Content type: Research

    For patients with thromboangiitis obliterans (TAO), revascularization with bypass or angioplasty is frequently not feasible due to the poor outflow of the distal small vessels. We evaluated the long-term resul...

    Authors: Jianming Guo, Lianrui Guo, Shijun Cui, Zhu Tong, Alan Dardik and Yongquan Gu

    Citation: Stem Cell Research & Therapy 2018 9:43

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