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  1. Content type: Research

    Spermatogonial stem cell transplantation (SSCT) is a promising therapy in restoring the fertility of childhood cancer survivors. However, the low efficiency of SSCT is a significant concern. SSCT could be impr...

    Authors: Prashant Kadam, Elissavet Ntemou, Jaime Onofre, Dorien Van Saen and Ellen Goossens

    Citation: Stem Cell Research & Therapy 2019 10:310

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  2. Content type: Research

    Adipose tissue-derived mesenchymal stem cells (ASCs) offer a promising cell source for therapeutic applications in musculoskeletal disorders. The appropriate selection of ASCs from various fat depots for cell-...

    Authors: Stefan Arnhold, Mohamed I. Elashry, Michele C. Klymiuk and Florian Geburek

    Citation: Stem Cell Research & Therapy 2019 10:309

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  3. Content type: Research

    We used multimodal compositional magnetic resonance imaging (MRI) techniques, combined with clinical outcomes, to differentiate the alternations of composition in repair cartilage with allogeneic human adipose...

    Authors: Xinxin Zhao, Jingjing Ruan, Hui Tang, Jia Li, Yingxuan Shi, Meng Li, Suke Li, Cuili Xu, Qing Lu and Chengxiang Dai

    Citation: Stem Cell Research & Therapy 2019 10:308

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  4. Content type: Research

    Adipose tissue-derived mesenchymal stem cells (ADSCs) are promising candidates for regenerative medicine. However, long-term in vitro passaging leads to stemness loss and cell senescence of ADSCs, resulting in...

    Authors: Naishun Liao, Yingjun Shi, Cuilin Zhang, Youshi Zheng, Yingchao Wang, Bixing Zhao, Yongyi Zeng, Xiaolong Liu and Jingfeng Liu

    Citation: Stem Cell Research & Therapy 2019 10:306

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  5. Content type: Research

    Within the last years, the interest in physical exercise as non-invasive stimulus influencing circulating hematopoietic stem and progenitor cell (CPC) concentrations has constantly grown. Cell estimates are of...

    Authors: Julia M. Kröpfl, Michelle Schmid, Yvonne Di Marzio, Karine Schreiber and Christina M. Spengler

    Citation: Stem Cell Research & Therapy 2019 10:305

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  6. Content type: Research

    There are currently no effective treatments available for patients with irreversible loss of salivary gland (SG) function caused by radiation therapy for head and neck cancer. In this study, we have developed ...

    Authors: Takashi I., Yoshinori Sumita, Takako Yoshida, Ryo Honma, Mayumi Iwatake, Jorge Luis Montenegro Raudales, Tomoko Shizuno, Shinichiro Kuroshima, Haruchika Masuda, Makoto Seki, Simon D. Tran, Takayuki Asahara and Izumi Asahina

    Citation: Stem Cell Research & Therapy 2019 10:304

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  7. Content type: Research

    A refractory wound is a typical complication of diabetes and is a common outcome after surgery. Current approaches have difficulty in improving wound healing. Recently, non-expanded stromal vascular fraction (...

    Authors: Hongsen Bi, Hui Li, Chen Zhang, Yiqing Mao, Fangfei Nie, Ying Xing, Wuga Sha, Xi Wang, David M. Irwin and Huanran Tan

    Citation: Stem Cell Research & Therapy 2019 10:302

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  8. Content type: Research

    Placenta-derived MSCs (P-MSCs) represent a promising tool for cell-based therapeutic applications. However, the increasing demand for P-MSCs in clinical trials makes high quality and large number of P-MSCs man...

    Authors: Qilin Huang, Yi Yang, Chen Luo, Yi Wen, Ruohong Liu, Shuai Li, Tao Chen, Hongyu Sun and Lijun Tang

    Citation: Stem Cell Research & Therapy 2019 10:301

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  9. Content type: Research

    Systemic inflammatory response syndrome (SIRS) is common in severe fulminant hepatic failure (FHF) and has a high mortality rate (20–50%) due to irreversible cerebral edema or sepsis. Stem cell-based treatment...

    Authors: Shobha Regmi, Shiva Pathak, Tung Pham Thanh, Tiep Tien Nguyen, Jong-Hyuk Sung, Simmyung Yook, Jong Oh. Kim, Chul Soon Yong, Inho Choi, Kyoung-Oh Doh, Pil-Hoon Park, Jun-Beom Park, Yoojin Seo, Bieong-Kil Kim, Dong-Mok Lee, Ik-Jae Moon…

    Citation: Stem Cell Research & Therapy 2019 10:230

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  10. Content type: Research

    Bone marrow mesenchymal stem cells (MSCs) are among the most common cell types to be used and studied for cardiac regeneration. Low survival rate and difficult retention of delivered MSCs in infarcted heart re...

    Authors: Peisen Huang, Li Wang, Qing Li, Jun Xu, Junyan Xu, Yuyan Xiong, Guihao Chen, Haiyan Qian, Chen Jin, Yuan Yu, Jiandong Liu, Li Qian and Yuejin Yang

    Citation: Stem Cell Research & Therapy 2019 10:300

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  11. Content type: Research

    Many adult women younger than 40 years old have premature ovarian failure (POF) and infertility. Previous studies confirmed that different tissue-derived stem cells could restore ovarian function and folliculo...

    Authors: Rongxia Liu, Xiaoyu Zhang, Zhenhai Fan, Yuying Wang, Guanping Yao, Xue Wan, Zulin Liu, Bing Yang and Limei Yu

    Citation: Stem Cell Research & Therapy 2019 10:299

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  12. Content type: Research

    Although tissue-engineered cartilage has been broadly studied, complete integration of regenerated cartilage with residual cartilage is still difficult for the inferior mechanical and biochemical feature of ne...

    Authors: Baixiang Cheng, Teng Tu, Xiao Shi, Yanzheng Liu, Ying Zhao, Yinhua Zhao, Yijie Li, Hui Chen, Yongjin Chen and Min Zhang

    Citation: Stem Cell Research & Therapy 2019 10:298

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  13. Content type: Review

    Odontoblasts are cells that contribute to the formation of the dental pulp complex. The differentiation of dental tissue-derived mesenchymal stem cells into odontoblasts comprises many factors and signaling pa...

    Authors: Fuchun Fang, Kaiying Zhang, Zhao Chen and Buling Wu

    Citation: Stem Cell Research & Therapy 2019 10:297

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  14. Content type: Research

    A dynamic interaction between tumor cells and its surrounding stroma promotes the initiation, progression, metastasis, and chemoresistance of solid tumors. Emerging evidences suggest that targeting the stromal...

    Authors: Tithi Ghosh, Partha Nandi, Nilanjan Ganguly, Ipsita Guha, Avishek Bhuniya, Sarbari Ghosh, Anirban Sarkar, Akata Saha, Shayani Dasgupta, Rathindranath Baral and Anamika Bose

    Citation: Stem Cell Research & Therapy 2019 10:296

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  15. Content type: Research

    Interleukin 33 is known to have an important influence in the process of myocardial infarction, and the immunoregulatory function of MSCs could be influenced by cell factors. In this study, we evaluated the th...

    Authors: Yueqiu Chen, Jianfeng Zuo, Weiqian Chen, Ziying Yang, Yanxia Zhang, Fei Hua, Lianbo Shao, Jingjing Li, Yihuan Chen, Yunsheng Yu and Zhenya Shen

    Citation: Stem Cell Research & Therapy 2019 10:295

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  16. Content type: Research

    Accumulation of vascular smooth muscle cells (VSMCs) within the neointimal region is a hallmark of atherosclerosis and vessel injury. Evidence has shown that Sca-1-positive (Sca-1+) progenitor cells residing i...

    Authors: Yan Wu, Xin Liu, Ling-Yun Guo, Lei Zhang, Fei Zheng, Shan Li, Xing-Yuan Li, Ye Yuan, Yu Liu, Yu-wen Yan, Shi-You Chen, Jia-Ning Wang, Jin-xuan Zhang and Jun-Ming Tang

    Citation: Stem Cell Research & Therapy 2019 10:294

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  17. Content type: Review

    The field of regenerative medicine provides enormous opportunities for generating beta cells from different stem cell sources for cellular therapy. Even though insulin-secreting cells can be generated from a v...

    Authors: Nimshitha Pavathuparambil Abdul Manaph, Kisha N. Sivanathan, Jodie Nitschke, Xin-Fu Zhou, Patrick T. Coates and Christopher John Drogemuller

    Citation: Stem Cell Research & Therapy 2019 10:293

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  18. Content type: Research

    In the field of regenerative medicine, delivery of human adipose-derived mesenchymal stem/stromal cells (hASCs) has shown great promise to promote wound healing. However, a hostile environment of the injured t...

    Authors: Jasmi Kiiskinen, Arto Merivaara, Tiina Hakkarainen, Minna Kääriäinen, Susanna Miettinen, Marjo Yliperttula and Raili Koivuniemi

    Citation: Stem Cell Research & Therapy 2019 10:292

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  19. Content type: Research

    The lack of anti-fibrotic agents targeting intestinal fibrosis is a large unmet need in inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis. Previous studies have found that perinatal...

    Authors: Yoon Jeong Choi, Jun Bon Koo, Hee Yeon Kim, Jin Won Seo, Eun Jeong Lee, Woo Ram Kim, Joo Young Cho, Ki Baik Hahm, Sung Pyo Hong, Duk Hwan Kim and Jun-Hwan Yoo

    Citation: Stem Cell Research & Therapy 2019 10:291

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  20. Content type: Research

    Lung transplantation is a life-saving surgical replacement of diseased lungs in patients with end-stage respiratory malfunctions. Despite remarkable short-term recovery, long-term lung survival continues to fa...

    Authors: Mohammad Afzal Khan, Fatimah Alanazi, Hala Abdalrahman Ahmed, Talal Shamma, Kilian Kelly, Mohamed A. Hammad, Abdullah O. Alawad, Abdullah Mohammed Assiri and Dieter Clemens Broering

    Citation: Stem Cell Research & Therapy 2019 10:290

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  21. Content type: Research

    Stem cell-derived pancreatic β-like cells hold great promise for treating diabetes. Gallbladder belongs to the extrahepatic bile duct system and possesses stem-like cells. These stem cells could be expanded in...

    Authors: Fei Chen, Tuo Li, Yu Sun, Qinggui Liu, Tao Yang, Jiajia Chen, Haiying Zhu, Yongquan Shi, Yi-Ping Hu and Min-Jun Wang

    Citation: Stem Cell Research & Therapy 2019 10:289

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  22. Content type: Review

    After the initial investigations into applications of mesenchymal stem cells (MSCs) for cell therapy, there was increased interest in their secreted soluble factors. Following studies of MSCs and their secrete...

    Authors: Kyong-Su Park, Elga Bandeira, Ganesh V. Shelke, Cecilia Lässer and Jan Lötvall

    Citation: Stem Cell Research & Therapy 2019 10:288

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  23. Content type: Research

    miRNA expression profiles in ectopic endometrium (EC) serving as pathophysiologic genetic fingerprints contribute to determining endometriosis progression; however, the underlying molecular mechanisms remain u...

    Authors: Chen-Fei Zhou, Min-Juan Liu, Wei Wang, Sha Wu, Yu-Xin Huang, Guo-Bin Chen, Li-Min Liu, Dong-Xian Peng, Xue-Feng Wang, Xu-Zi Cai, Xiao-Xuan Li, Wan-Qin Feng and Ying Ma

    Citation: Stem Cell Research & Therapy 2019 10:287

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  24. Content type: Research

    Adult mesenchymal stem cells (MSCs) improve the host response during experimental sepsis in animals. MSCs from various sources express a procoagulant activity that has been linked to the expression of tissue f...

    Authors: Desirée Perlee, Alex F. de Vos, Brendon P. Scicluna, Anja Maag, Pablo Mancheño, Olga de la Rosa, Wilfried Dalemans, Sandrine Florquin, Cornelis van’t Veer, Eleuterio Lombardo and Tom van der Poll

    Citation: Stem Cell Research & Therapy 2019 10:286

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  25. Content type: Research

    Mesenchymal stromal cells (MSCs) are used in over 800 clinical trials mainly due to their immune inhibitory activity. Umbilical cord (UC), the second leading source of clinically used MSCs, is usually cut in s...

    Authors: Anton Selich, Katharina Zimmermann, Michel Tenspolde, Oliver Dittrich-Breiholz, Constantin von Kaisenberg, Axel Schambach and Michael Rothe

    Citation: Stem Cell Research & Therapy 2019 10:285

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  26. Content type: Research

    Transient receptor potential vanilloid 1 (TRPV1), recognized as a hyperosmolarity sensor, is a crucial ion channel involved in the pathogenesis of neural and glial signaling. Recently, TRPV1 was determined to ...

    Authors: Chih-Chien Hsu, Ke-Hung Chien, Aliaksandr A. Yarmishyn, Waradee Buddhakosai, Wen-Ju Wu, Tai-Chi Lin, Shih-Hwa Chiou, Jiann-Torng Chen, Chi-Hsien Peng, De-Kuang Hwang, Shih-Jen Chen and Yuh-Lih Chang

    Citation: Stem Cell Research & Therapy 2019 10:284

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  27. Content type: Research

    Cryopreservation of fat grafts facilitates reinjection for later use. However, low temperature and thawing can disrupt tissues and cause lipid leakage, which raises safety concerns. Here, we compared the cryop...

    Authors: Jingwei Feng, Wansheng Hu, Mimi Lalrimawii Fanai, Shengqian Zhu, Jing Wang, Junrong Cai and Feng Lu

    Citation: Stem Cell Research & Therapy 2019 10:283

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  28. Content type: Research

    Recent studies suggested that miR-17~106 family was involved in the regulation of neural stem/progenitor cells (NPCs). However, distinct function of each family member was reported in regulating stem cells within...

    Authors: Xiaohuan Xia, Hongfang Lu, Chunhong Li, Yunlong Huang, Yi Wang, Xiaoyu Yang and Jialin C. Zheng

    Citation: Stem Cell Research & Therapy 2019 10:282

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  29. Content type: Research

    Autologous epidermal basal cell suspension therapy has been proven to be one of the most effective treatments for full-thickness wounds. However, we found there remain obvious defects that significantly confin...

    Authors: Peng Wang, Zhicheng Hu, Xiaoling Cao, Shaobin Huang, Yunxian Dong, Pu Cheng, Hailin Xu, Bin Shu, Julin Xie, Jun Wu, Bing Tang and Jiayuan Zhu

    Citation: Stem Cell Research & Therapy 2019 10:154

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  30. Content type: Review

    Stem cell therapy has been applied in many fields. Basic and clinical studies on stem cell therapy for acute kidney injury (AKI) have been conducted. Stem cells have been found to exert renal protection throug...

    Authors: Si-Yang Wang, Quan Hong, Chao-Yang Zhang, Yuan-Jun Yang, Guang-Yan Cai and Xiang-Mei Chen

    Citation: Stem Cell Research & Therapy 2019 10:281

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  31. Content type: Research

    The incidence of obesity and diabetes is increasing rapidly. Optimal management is still elusive. Obesity associated with type 2 diabetes is known to cause adipose tissue inflammation, increase oxidative stres...

    Authors: Cleyton C. Domingues, Nabanita Kundu, Yana Kropotova, Neeki Ahmadi and Sabyasachi Sen

    Citation: Stem Cell Research & Therapy 2019 10:280

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  32. Content type: Research

    Autograft microskin transplantation has been widely used as a skin graft therapy in full-thickness skin defect. However, skin grafting failure can lead to a pathological delay wound healing due to a poor vascu...

    Authors: Yuansen Luo, Xiaoyou Yi, Tangzhao Liang, Shihai Jiang, Ronghan He, Ying Hu, Li Bai, Chunmei Wang, Kun Wang and Lei Zhu

    Citation: Stem Cell Research & Therapy 2019 10:279

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  33. Content type: Review

    Exosomes, nanosized extracellular vesicles of 30–150 nm, are shed by almost all cell types. Bearing proteins, lipids, RNAs, and DNAs, exosomes have emerged as vital biological mediators in cell-to-cell communi...

    Authors: Na Li, Lu Zhao, Yankai Wei, Vicki L. Ea, Hong Nian and Ruihua Wei

    Citation: Stem Cell Research & Therapy 2019 10:278

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  34. Content type: Research

    Chrysosplenetin is an O-methylated flavonol compound isolated from the plant Chamomilla recutita and Laggera pterodonta. The aim of our research is to evaluate the function of Chrysosplenetin on osteogenesis of h...

    Authors: Guoju Hong, Xiaoming He, Yingshan Shen, Xiaojun Chen, Fang Yang, Peng Yang, Fengxiang Pang, Xiaorui Han, Wei He and Qiushi Wei

    Citation: Stem Cell Research & Therapy 2019 10:277

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  35. Content type: Research

    Tooth loss caused by caries or injuries has a negative effect on human health; thus, it is important to develop a reliable method of tooth regeneration. Research on tooth regeneration has mainly focused on mou...

    Authors: Qian Li, Siqi Zhang, Yi Sui, Xiaoming Fu, Yan Li and Shicheng Wei

    Citation: Stem Cell Research & Therapy 2019 10:276

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  36. Content type: Research

    Hypertrophic scars (HSs) are formed via an aberrant response to the wound healing process. HSs can be cosmetic or can result in functional problems. Prolonged proliferation and remodeling phases disrupt wound ...

    Authors: Ching-Hsuan Hu, Yi-Wen Tseng, Chih-Yung Chiou, Kuan-Chun Lan, Chih-Hung Chou, Chun-San Tai, Hsien-Da Huang, Chiung-Wen Hu, Ko-Hsun Liao, Shiow-Shuh Chuang, Jui-Yung Yang and Oscar K. Lee

    Citation: Stem Cell Research & Therapy 2019 10:275

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  37. Content type: Research

    Retrotransposition of protein-coding genes is thought to occur due to the existence of numerous processed pseudogenes in both animals and plants. Unlike retrotransposons including Alu and LINE-1, direct evidence ...

    Authors: Saki Aoto, Saki Katagiri, Yi Wang, Alistair T. Pagnamenta, Rie Sakamoto-Abutani, Masashi Toyoda, Akihiro Umezawa and Kohji Okamura

    Citation: Stem Cell Research & Therapy 2019 10:273

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  38. Content type: Research

    Oligodendrocytes are a type of glial cells that synthesize the myelin sheath around the axons and are critical for the nerve conduction in the CNS. Oligodendrocyte death and defects are the leading causes of s...

    Authors: Poommaree Namchaiw, Han Wen, Florian Mayrhofer, Olga Chechneva, Sangita Biswas and Wenbin Deng

    Citation: Stem Cell Research & Therapy 2019 10:272

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  39. Content type: Research

    Male infertility is a serious social problem in modern society. Nonobstructive azoospermia (NOA) caused by germ cell gene defects is an important reason for male infertility, but effective clinical treatment f...

    Authors: Xiaoyu Li, Tiecheng Sun, Xiuxia Wang, Jixin Tang and Yixun Liu

    Citation: Stem Cell Research & Therapy 2019 10:271

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  40. Content type: Research

    Testicular torsion is an urological emergency that may lead to infertility due to ischemic injury. Promptly surgical correction by orchiopexy is the only way to avoid infertility and no effective treatment for...

    Authors: Chi-Hao Hsiao, Andrea Tung-Qian Ji, Chih-Cheng Chang, Ming-Hsien Chien, Liang-Ming Lee and Jennifer Hui-Chun Ho

    Citation: Stem Cell Research & Therapy 2019 10:270

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  41. Content type: Research

    Adult stem cells and progenitors are responsible for breast tissue regeneration. Human breast epithelial progenitors are organized in a lineage hierarchy consisting of bipotent progenitors (BPs), myoepithelial...

    Authors: Vasudeva Bhat, Victoria Lee-Wing, Pingzhao Hu and Afshin Raouf

    Citation: Stem Cell Research & Therapy 2019 10:269

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  42. Content type: Research

    PBX homeobox 1 (PBX1) is involved in the maintenance of the pluripotency of human embryonic and hematopoietic stem cells; however, the effects of PBX1 in the self-renewal and reprogramming of hair follicle mes...

    Authors: Yixu Jiang, Feilin Liu, Fei Zou, Yingyao Zhang, Bo Wang, Yuying Zhang, Aobo Lian, Xing Han, Zinan Liu, Xiaomei Liu, Minghua Jin, Dianliang Wang, Gang Li and Jinyu Liu

    Citation: Stem Cell Research & Therapy 2019 10:268

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  43. Content type: Research

    Mesenchymal stem cells (MSCs) have been recognized as a promising tool for the treatment of various inflammatory disorders and autoimmune diseases. Stress conditions affect immune-mediated treatment and activa...

    Authors: Shuizhong Cen, Peng Wang, Zhongyu Xie, Rui Yang, Jinteng Li, Zhenhua Liu, Shan Wang, Xiaohua Wu, Wenjie Liu, Ming Li, Su’an Tang, Huiyong Shen and Yanfeng Wu

    Citation: Stem Cell Research & Therapy 2019 10:265

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  44. Content type: Research

    Myocardial fibrosis is a common pathophysiological change in cardiovascular disease, which can cause cardiac dysfunction and even sudden death. Excessively activated fibroblasts proliferate and secret excessiv...

    Authors: Fengxia Lin, Zhicong Zeng, Yinzhi Song, Liang Li, Zijun Wu, Xiaoduo Zhang, Zhiwen Li, Xiao Ke and Xun Hu

    Citation: Stem Cell Research & Therapy 2019 10:263

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  45. Content type: Research

    The efficacy of mesenchymal stem cell (MSC)-based therapy for acute liver injury (ALI) involves coordination with the hepatic immune system, a complex and coordinated network of immune-cell interactions. Howev...

    Authors: Jingqi Liu, Bing Feng, Yanping Xu, Jiaqi Zhu, Xudong Feng, Wenyi Chen, Xinyu Sheng, Xiaowei Shi, Qiaoling Pan, Jiong Yu, Xun Zeng, Hongcui Cao and Lanjuan Li

    Citation: Stem Cell Research & Therapy 2019 10:262

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  46. Content type: Letter

    Recently published article by Pieri’s group suggested that follicle-stimulating hormone (FSH) activates canine testicular spermatogonial stem cells (SSCs) and results in increased expression of pluripotent mar...

    Authors: Hiren Patel and Deepa Bhartiya

    Citation: Stem Cell Research & Therapy 2019 10:261

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