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  1. Radiation-induced rectal epithelial damage is a very common side effect of pelvic radiotherapy and often compromise the life quality and treatment outcome in patients with pelvic malignancies. Unlike small bow...

    Authors: Felipe Rodriguez Tirado, Payel Bhanja, Eduardo Castro-Nallar, Ximena Diaz Olea, Catalina Salamanca and Subhrajit Saha

    Citation: Stem Cell Research & Therapy 2021 12:63

    Content type: Research

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  2. Hair follicle (HF) development and growth are dependent on epithelial-mesenchymal interactions (EMIs). Dermal papilla (DP) cells are recognized as the key inductive mesenchymal player, but the ideal source of ...

    Authors: Carla M. Abreu, Rogério P. Pirraco, Rui L. Reis, Mariana T. Cerqueira and Alexandra P. Marques

    Citation: Stem Cell Research & Therapy 2021 12:62

    Content type: Research

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  3. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xiaozhen Yu, Pengpeng Sun, Xingang Huang, Hua Chen, Weiqing Huang, Yingchun Ruan, Weina Jiang, Xiaohua Tan and Zhijing Liu

    Citation: Stem Cell Research & Therapy 2021 12:61

    Content type: Correction

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    The original article was published in Stem Cell Research & Therapy 2020 11:454

  4. Mesenchymal stem cells (MSCs) have unique and beneficial properties and are currently used to treat a broad variety of diseases. These properties include the potential for differentiation into other cell types...

    Authors: Sara Galindo, Ana de la Mata, Marina López-Paniagua, Jose M. Herreras, Inmaculada Pérez, Margarita Calonge and Teresa Nieto-Miguel

    Citation: Stem Cell Research & Therapy 2021 12:60

    Content type: Review

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  5. Aging is known to slow the neurogenic capacity of the hippocampus, one of only two mammalian adult neurogenic niches. The reduction of adult-born neurons with age may initiate cognitive decline progression whi...

    Authors: Nathalie Sumien, Matthew S. Wells, Akram Sidhu, Jessica M. Wong, Michael J. Forster, Qiao-Xi Zheng and Judith A. Kelleher-Andersson

    Citation: Stem Cell Research & Therapy 2021 12:59

    Content type: Short report

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  6. Critical limb ischemia (CLI) is the most advanced form of peripheral arterial disease (PAD) characterized by ischemic rest pain and non-healing ulcers. Currently, the standard therapy for CLI is the surgical r...

    Authors: Pegah Nammian, Seyedeh-Leili Asadi-Yousefabad, Sajad Daneshi, Mohammad Hasan Sheikhha, Seyed Mohammad Bagher Tabei and Vahid Razban

    Citation: Stem Cell Research & Therapy 2021 12:58

    Content type: Research

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  7. Stem cells from human exfoliated deciduous teeth (SHED) have been reported to show the in vivo and in vitro hepatic differentiation, SHED-Heps; however, the cholangiogenic potency of SHED-Heps remains unclear....

    Authors: Ratih Yuniartha, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Yoshinao Oda, Shouichi Ohga and Tomoaki Taguchi

    Citation: Stem Cell Research & Therapy 2021 12:57

    Content type: Research

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  8. In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients’ survival rate. Bone marrow mesenchymal stem cells...

    Authors: Pengyu Zhou, Hao Liu, Ximao Liu, Xiao Ling, Zezhou Xiao, Peng Zhu, Yufeng Zhu, Jun Lu and Shaoyi Zheng

    Citation: Stem Cell Research & Therapy 2021 12:56

    Content type: Research

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  9. Human induced pluripotent stem cells (hiPSCs) hold enormous promise in accelerating breakthroughs in understanding human development, drug screening, disease modeling, and cell and gene therapies. Their potent...

    Authors: Breanna S. Borys, Tiffany Dang, Tania So, Leili Rohani, Tamas Revay, Tylor Walsh, Madalynn Thompson, Bob Argiropoulos, Derrick E. Rancourt, Sunghoon Jung, Yas Hashimura, Brian Lee and Michael S. Kallos

    Citation: Stem Cell Research & Therapy 2021 12:55

    Content type: Research

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  10. Chronic obstructive pulmonary disease (COPD) is an incurable and debilitating chronic disease characterized by progressive airflow limitation associated with abnormal levels of tissue inflammation. Therefore, ...

    Authors: Noridzzaida Ridzuan, Norashikin Zakaria, Darius Widera, Jonathan Sheard, Mitsuru Morimoto, Hirofumi Kiyokawa, Seoparjoo Azmel Mohd Isa, Gurjeet Kaur Chatar Singh, Kong-Yong Then, Ghee-Chien Ooi and Badrul Hisham Yahaya

    Citation: Stem Cell Research & Therapy 2021 12:54

    Content type: Research

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  11. Mesenchymal stromal cell (MSC)-based therapies are being actively investigated in various inflammatory disorders. However, functional variability among MSCs cultured in vitro will lead to distinct therapeutic ...

    Authors: Changbin Sun, Kehua Zhang, Jianhui Yue, Shufang Meng and Xi Zhang

    Citation: Stem Cell Research & Therapy 2021 12:53

    Content type: Research

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  12. Retinitis pigmentosa (RP) is a progressive inherited retinal disease with great interest for finding effective treatment modalities. Stem cell-based therapy is one of the promising candidates. We aimed to inve...

    Authors: Aekkachai Tuekprakhon, Siripakorn Sangkitporn, Adisak Trinavarat, Aulia Rahmi Pawestri, Visit Vamvanij, Monchai Ruangchainikom, Panya Luksanapruksa, Phitchapa Pongpaksupasin, Areerat Khorchai, Acharaporn Dambua, Patcharaporn Boonchu, Chonlada Yodtup, Mongkol Uiprasertkul, Somchai Sangkitporn and La-ongsri Atchaneeyasakul

    Citation: Stem Cell Research & Therapy 2021 12:52

    Content type: Research

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  13. In the brain of adult mammals, neural stem cells persist in the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus, which are specialized niches with proliferative capac...

    Authors: Wen Li, Shanshan Wang, Hui He, Jianbing Qin, Xiang Cheng, Heyan Zhao, Meiling Tian, Xinhua Zhang and Guohua Jin

    Citation: Stem Cell Research & Therapy 2021 12:51

    Content type: Research

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  14. Muscle stem cells (MuSCs) are absolutely required for the formation, repair, and regeneration of skeletal muscle tissue. Increasing evidence demonstrated that tissue stem cells, especially mesenchymal stem cel...

    Authors: Shengchao Zhang, Jiankai Fang, Zhanhong Liu, Pengbo Hou, Lijuan Cao, Yuyan Zhang, Rui Liu, Yanan Li, Qianwen Shang, Yongjing Chen, Chao Feng, Guan Wang, Gerry Melino, Ying Wang, Changshun Shao and Yufang Shi

    Citation: Stem Cell Research & Therapy 2021 12:50

    Content type: Research

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  15. Diabetic wounds remain a challenging clinical problem, which requires further treatment development. Published data showed that dermis-derived stem/progenitor cells (DSPCs) display superior wound healing in vi...

    Authors: Yu Xin, Peng Xu, Xiangsheng Wang, Yunsheng Chen, Zheng Zhang and Yixin Zhang

    Citation: Stem Cell Research & Therapy 2021 12:49

    Content type: Research

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  16. Spinal cord injury (SCI) is a neurological, medically incurable disorder. Human pluripotent stem cells (hPSCs) have the potential to generate neural stem/progenitor cells (NS/PCs), which hold promise in the tr...

    Authors: Rui Bai, Yun Chang, Amina Saleem, Fujian Wu, Lei Tian, Siyao Zhang, Ya’nan Li, Shuhong Ma, Tao Dong, Tianwei Guo, Youxu Jiang, Yi You, Wen-Jing Lu, Hong Feng Jiang and Feng Lan

    Citation: Stem Cell Research & Therapy 2021 12:48

    Content type: Research

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  17. Paracrine signaling from endothelial progenitor cells (EPCs) is beneficial for angiogenesis and thus promotes tissue regeneration. Microgravity (MG) environment is found to facilitate the functional potentials...

    Authors: Lingchi Kong, Yan Wang, Haixing Wang, Qi Pan, Rongtai Zuo, Shanshan Bai, Xiaoting Zhang, Wayne Yukwai Lee, Qinglin Kang and Gang Li

    Citation: Stem Cell Research & Therapy 2021 12:47

    Content type: Research

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  18. Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) are regarded as promising cell type for cardiac cell replacement therapy, but it is not known whether the developmental stage influences their per...

    Authors: Gabriel Peinkofer, Martina Maass, Kurt Pfannkuche, Agapios Sachinidis, Stephan Baldus, Jürgen Hescheler, Tomo Saric and Marcel Halbach

    Citation: Stem Cell Research & Therapy 2021 12:46

    Content type: Research

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  19. Age-related bone loss plays a vital role in the development of osteoporosis and osteoporotic fracture. Bone marrow stromal cell (BMSC) senescence is highly associated with osteoporosis and limits the applicati...

    Authors: Lingxian Yi, Yue Ju, Ying He, Xiushan Yin, Ye Xu and Tujun Weng

    Citation: Stem Cell Research & Therapy 2021 12:45

    Content type: Research

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  20. To investigate the in vitro and in vivo anti-inflammatory/anti-fibrotic capacity of IFP-MSC manufactured as 3D spheroids. Our hypothesis is that IFP-MSC do not require prior cell priming to acquire a robust im...

    Authors: Dimitrios Kouroupis, Melissa A. Willman, Thomas M. Best, Lee D. Kaplan and Diego Correa

    Citation: Stem Cell Research & Therapy 2021 12:44

    Content type: Research

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  21. Epidermal stem cells (EpSCs) can self-renew, which are responsible for the long-term maintenance of the skin, and it also plays a critical role in wound re-epithelization, but the mechanism underlying EpSCs pr...

    Authors: Xiaohong Zhao, Ruyu Bian, Fan Wang, Ying Wang, Xue Li, Yicheng Guo, Xiaorong Zhang, Gaoxing Luo and Rixing Zhan

    Citation: Stem Cell Research & Therapy 2021 12:42

    Content type: Research

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  22. Derivation of osteoblast-like cells from human pluripotent stem cells (hPSCs) is a popular topic in bone tissue engineering. Although many improvements have been achieved, the low induction efficiency because ...

    Authors: Ping Zhou, Jia-Min Shi, Jing-E Song, Yu Han, Hong-Jiao Li, Ya-Meng Song, Fang Feng, Jian-Lin Wang, Rui Zhang and Feng Lan

    Citation: Stem Cell Research & Therapy 2021 12:41

    Content type: Research

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  23. Mesenchymal stem cell (MSC)-based therapy has the potential for immunomodulation and enhancement of tissue regeneration. Genetically modified MSCs that over-express specific cytokines, growth factors, or chemo...

    Authors: Ning Zhang, Chi-Wen Lo, Takeshi Utsunomiya, Masahiro Maruyama, Ejun Huang, Claire Rhee, Qi Gao, Zhenyu Yao and Stuart B. Goodman

    Citation: Stem Cell Research & Therapy 2021 12:40

    Content type: Research

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  24. Precision or individualized medicine is increasingly pervasive across medical and surgical disciplines. However, the concept has not been introduced in regenerative medicine.

    Authors: Amy L. Lightner and Timothy Chan

    Citation: Stem Cell Research & Therapy 2021 12:39

    Content type: Viewpoint

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  25. Botulinum toxin (Botox) injection is in widespread clinical use for the treatment of muscle spasms and tendinopathy but the mechanism of action is poorly understood.

    Authors: Peilin Chen, Ziming Chen, Christopher Mitchell, Junjie Gao, Lianzhi Chen, Allan Wang, Toby Leys, Euphemie Landao-Bassonga, Qiujian Zheng, Tao Wang and Minghao Zheng

    Citation: Stem Cell Research & Therapy 2021 12:38

    Content type: Research

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  26. Inflammatory bowel disease is a chronic and excessive inflammation of the colon and small intestine. We previously reported that priming of mesenchymal stromal cells (MSCs) with poly(I:C) induced them to expre...

    Authors: Ji-Young Lim, Byung-Su Kim, Da-Bin Ryu, Tae Woo Kim, Gyeongsin Park and Chang-Ki Min

    Citation: Stem Cell Research & Therapy 2021 12:37

    Content type: Research

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  27. The spinal cord is part of the central nervous system (CNS) and serves to connect the brain to the peripheral nervous system and peripheral tissues. The cell types that primarily comprise the spinal cord are n...

    Authors: Bin Lv, Xing Zhang, Jishan Yuan, Yongxin Chen, Hua Ding, Xinbing Cao and Anquan Huang

    Citation: Stem Cell Research & Therapy 2021 12:36

    Content type: Review

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  28. Periodontitis is a chronic inflammatory disease inducing the absorption of alveolar bone and leading to tooth loss. Human amnion-derived mesenchymal stem cells (HAMSCs) have been used for studying inflammatory...

    Authors: Yuli Wang, Fengyi Lv, Lintong Huang, Hengwei Zhang, Bing Li, Weina Zhou, Xuan Li, Yifei Du, Yongchu Pan and Ruixia Wang

    Citation: Stem Cell Research & Therapy 2021 12:35

    Content type: Research

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  29. Lower back pain is often accredited to loss of intervertebral disc (IVD) height and compromised spine stability as a result of intervertebral disc degeneration (IVDD). We aim to locally use bleomycin to induce...

    Authors: Xiao Yang, Zhiqian Chen, Chen Chen, Chen Han, Yifan Zhou, Xunlin Li, Haijun Tian, Xiaofei Cheng, Kai Zhang, An Qin, Tangjun Zhou and Jie Zhao

    Citation: Stem Cell Research & Therapy 2021 12:34

    Content type: Research

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  30. Our aim was to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI).

    Authors: Runfeng Zhang, Jiang Yu, Ningkun Zhang, Wensong Li, Jisheng Wang, Guocai Cai, Yu Chen, Yong Yang and Zhenhong Liu

    Citation: Stem Cell Research & Therapy 2021 12:33

    Content type: Research

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  31. Fistulas have puzzled us all the time and stem cell therapy for it is still in its infancy. We conducted a meta-analysis and systematic review to evaluate the efficacy of stem cells and its potential mechanism...

    Authors: Yantian Cao, Qi Su, Bangjie Zhang, Fangfang Shen and Shaoshan Li

    Citation: Stem Cell Research & Therapy 2021 12:32

    Content type: Review

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  32. Ulcerative colitis (UC) is a chronic and recurrent disease without satisfactory treatment strategies. Dental pulp stem cell (DPSC) transplantation has been proposed as a potential therapy for UC. This study ai...

    Authors: Ning Li, Yichi Zhang, Narayan Nepal, Guoqing Li, Ningning Yang, Haoyuan Chen, Qiuchi Lin, Xuechun Ji, Sijia Zhang and Shizhu Jin

    Citation: Stem Cell Research & Therapy 2021 12:30

    Content type: Research

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  33. Extracellular vesicles (EVs) and their mimics from mesenchymal stem cells (MSCs) are promising drug carriers to improve cancer treatment, but their application is hindered by donor variations and expansion lim...

    Authors: Qingguo Zhao, Bo Hai, Jack Kelly, Samuel Wu and Fei Liu

    Citation: Stem Cell Research & Therapy 2021 12:29

    Content type: Research

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  34. The therapeutic effect of mesenchymal stem cells (MSCs) from human adipose tissue on renal interstitial fibrosis has been demonstrated by several groups. However, the way to enhance the renoprotective effect o...

    Authors: Shulin Li, Yanping Wang, Zhuojun Wang, Lu Chen, Bangjie Zuo, Caixia Liu and Dong Sun

    Citation: Stem Cell Research & Therapy 2021 12:27

    Content type: Research

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  35. Bone marrow stromal cells (BMSC) show promise in cartilage repair, and sheep are the most common large animal pre-clinical model.

    Authors: K. Futrega, E. Music, P. G. Robey, S. Gronthos, R. Crawford, S. Saifzadeh, T. J. Klein and M. R. Doran

    Citation: Stem Cell Research & Therapy 2021 12:26

    Content type: Research

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  36. Umbilical cord mesenchymal stem cells (UC-MSCs) have certain advantages over other MSCs and about 300 clinical trials have been registered using UC-MSCs to treat diseases such as osteoarthritis, autoimmune dis...

    Authors: Shaoyang Zhang, Jing Yi Wang, Baojie Li, Feng Yin and Huijuan Liu

    Citation: Stem Cell Research & Therapy 2021 12:25

    Content type: Letter

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  37. Subretinal fibrosis resulting from neovascular age-related macular degeneration (nAMD) is one of the major causes of serious and irreversible vision loss worldwide, and no definite and effective treatment exis...

    Authors: Dongli Li, Junxiu Zhang, Zijia Liu, Yuanyuan Gong and Zhi Zheng

    Citation: Stem Cell Research & Therapy 2021 12:24

    Content type: Research

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  38. Mesenchymal stem cell-based acellular therapies have been widely exploited in managing hypertrophic scars. However, low maintenance dose and transitory therapeutic effects during topical medication remain a th...

    Authors: Chaoyu Zhang, Ting Wang, Li Zhang, Penghong Chen, Shijie Tang, Aizhen Chen, Ming Li, Guohao Peng, Hangqi Gao, Haiyan Weng, Haoruo Zhang, Shirong Li, Jinghua Chen, Liangwan Chen and Xiaosong Chen

    Citation: Stem Cell Research & Therapy 2021 12:23

    Content type: Research

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  39. Previous studies have suggested that promoting endogenous neurogenesis has great significance for the recovery of cognitive dysfunction caused by cerebral ischemia (CI). Pharmacological inhibition of GABAB recept...

    Authors: Dan Song, Yaohua Chen, Cheng Chen, Lili Chen and Oumei Cheng

    Citation: Stem Cell Research & Therapy 2021 12:22

    Content type: Research

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  40. Retinal degenerative diseases remain the dominant causes of blindness worldwide, and cell replacement is viewed as a promising therapeutic direction. However, the resources of seed cells are hard to obtain. To...

    Authors: Yifeng Ke, Xiaoe Fan, Rui Hao, Lijie Dong, Min Xue, Liangzhang Tan, Chunbo Yang, Xiaorong Li and Xinjun Ren

    Citation: Stem Cell Research & Therapy 2021 12:21

    Content type: Research

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  41. Spinal cord injury is a devastating clinical condition for which there are currently no effective therapeutic options. In the present study, we aim to investigate if the effect of an administered injection of ...

    Authors: Yong Cao, Yan Xu, Chunyuan Chen, Hui Xie, Hongbin Lu and Jianzhong Hu

    Citation: Stem Cell Research & Therapy 2021 12:20

    Content type: Research

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  42. Radial extracorporeal shockwave (r-ESW), an innovative and noninvasive technique, is gaining increasing attention in regenerative medicine due to its mechanobiological effects. Subchondral bone stem/progenitor...

    Authors: Zhidong Zhao, Yuxing Wang, Qian Wang, Jiawu Liang, Wei Hu, Sen Zhao, Peilin Li, Heng Zhu and Zhongli Li

    Citation: Stem Cell Research & Therapy 2021 12:19

    Content type: Research

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  43. Steroid-induced osteonecrosis of the femoral head (SONFH) is a devastating orthopedic disease, which seriously affects the quality of life of patients. The study aims to investigate the effects of LncRNA NORAD...

    Authors: Dapeng Fu, Sheng Yang, Jianmin Lu, Haoyi Lian and Kairong Qin

    Citation: Stem Cell Research & Therapy 2021 12:18

    Content type: Research

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  44. Hematopoietic stem cell (HSC) transplantation is an effective treatment strategy for many types of diseases. Peripheral blood (PB) is the most commonly used source of bone marrow (BM)-derived stem cells for cu...

    Authors: Xiao Fang, Xiong Fang, Yujia Mao, Aaron Ciechanover, Yan Xu, Jing An and Ziwei Huang

    Citation: Stem Cell Research & Therapy 2021 12:17

    Content type: Research

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  45. Our previous studies have proved the efficient exogenous repairing responses via bone marrow stem and progenitor cells (BMSPCs). However, the trafficking of endogenous bone marrow stem and progenitor cells to ...

    Authors: Wenting Gao, Xuetao Yang, Juan Du, Haiyan Wang, Hejiang Zhong, Jianxin Jiang and Ce Yang

    Citation: Stem Cell Research & Therapy 2021 12:16

    Content type: Research

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  46. Exosomal microRNAs (miRs) derived from mesenchymal stem cells (MSCs) have been shown to play roles in the pathophysiological processes of sepsis. Moreover, miR-27b is highly enriched in MSC-derived exosomes. H...

    Authors: Jia Sun, Xuan Sun, Junhui Chen, Xin Liao, Yixuan He, Jinsong Wang, Rui Chen, Sean Hu and Chen Qiu

    Citation: Stem Cell Research & Therapy 2021 12:14

    Content type: Research

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  47. The creation of a bioengineered cardiac patch (BCP) is a potential novel strategy for myocardial repair. Nevertheless, the ideal scaffold for BCP is unknown.

    Authors: Yu Jiang, Si-Jia Sun, Zhe Zhen, Rui Wei, Nannan Zhang, Song-Yan Liao and Hung-Fat Tse

    Citation: Stem Cell Research & Therapy 2021 12:13

    Content type: Research

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  48. Dystrophinopathy, a common neuromuscular disorder caused by the absence of dystrophin, currently lacks effective treatments. Systemic transplantation of adipose-derived stem cells (ADSCs) is a promising treatm...

    Authors: Liang Wang, Huan Li, Jinfu Lin, Ruojie He, Menglong Chen, Yu Zhang, Ziyu Liao and Cheng Zhang

    Citation: Stem Cell Research & Therapy 2021 12:12

    Content type: Research

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  49. Mesenchymal stromal cells (MSCs) have been introduced as promising cell source for regenerative medicine. Besides their multilineage differentiation capacity, MSCs release a wide spectrum of bioactive factors....

    Authors: Sebastian Wangler, Amir Kamali, Christina Wapp, Karin Wuertz-Kozak, Sonja Häckel, Claudia Fortes, Lorin M. Benneker, Lisbet Haglund, R. Geoff Richards, Mauro Alini, Marianna Peroglio and Sibylle Grad

    Citation: Stem Cell Research & Therapy 2021 12:11

    Content type: Research

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