Articles

A small molecule modulating monounsaturated fatty acids and Wnt signaling confers maintenance to induced pluripotent stem cells against endodermal differentiation

Stearoyl-coenzyme A desaturase 1 (SCD1) is required for de novo synthesis of fatty acids. Through the fatty acid acylation process, this enzyme orchestrates post-translational modifications to proteins involve...

Authors: Vahid Hosseini, Ashkan Kalantary-Charvadeh, Maryam Hajikarami, Parisa Fayyazpour, Reza Rahbarghazi, Mehdi Totonchi and Masoud Darabi

Induced pluripotent stem cells can improve thrombolytic effect of low-dose rt-PA after acute carotid thrombosis in rat

Intravenous thrombolysis using recombinant tissue plasminogen activator (rt-PA) is the standard treatment for acute ischemic stroke. Standard-dose rt-PA (0.9 mg/kg) is known to achieve good recanalization but ...

Authors: Hsi-Lung Hsieh, Ching-Chung Liang, Cheng-You Lu, Jen-Tsung Yang, Chiu-Yen Chung, Yu-Shien Ko and Tsong-Hai Lee

Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle

Alopecia areata (AA) is a common autoimmune hair loss disease with increasing incidence. Corticosteroids are the most widely used for hair loss treatment; however, long-term usage of hormonal drugs is associat...

Authors: Weiyue Deng, Yuying Zhang, Wei Wang, Aishi Song, Omar Mukama, Jiarong Huang, Xiaobo Han, Sihao Deng, Zuoxian Lin, Jean du Dieu Habimana, Rongqi Huang, Kexin Peng, Bing Ni, Shusheng Zhang, Xiaoxin Yan, Ji Li…

Red blood cells and their releasates compromise bone marrow-derived human mesenchymal stem/stromal cell survival in vitro

The use of bone marrow aspirate (BMA) and bone marrow aspirate concentrate (BMC) in the treatment of inflammatory orthopedic conditions has become a common practice. The therapeutic effect of BMA/BMC is though...

Authors: Ryan Christopher Dregalla, Jessica Ann Herrera and Edward Jeffery Donner

Hepatic progenitor cells promote the repair of schistosomiasis liver injury by inhibiting IL-33 secretion in mice

Hepatic schistosomiasis, a chronic liver injury induced by long-term Schistosoma japonicum (S. japonicum) infection, is characterized by egg granulomas and fibrotic pathology. Hepatic progenitor cells (HPCs), whi...

Authors: Beibei Zhang, Xiaoying Wu, Jing Li, An Ning, Bo Zhang, Jiahua Liu, Langui Song, Chao Yan, Xi Sun, Kuiyang Zheng and Zhongdao Wu

The safety of MSC therapy over the past 15 years: a meta-analysis

Despite increasing clinical investigations emphasizing the safety of mesenchymal stem cell (MSC) therapy in different populations with different diseases, no article has recently reviewed the adverse events in...

Authors: Yang Wang, Hanxiao Yi and Yancheng Song

Noncanonical Wnt5a signaling regulates tendon stem/progenitor cells senescence

The structural and functional properties of tendon decline with age, and these changes contribute to tendon disorder. Tendon stem/progenitor cells (TSPCs) play a vital role in tendon repair, regeneration and h...

Authors: Minhao Chen, Yingjuan Li, Longfei Xiao, Guangchun Dai, Panpan Lu and Yunfeng Rui

SUMO1 modification of IGF-1R combining with SNAI2 inhibited osteogenic differentiation of PDLSCs stimulated by high glucose

Periodontal disease, an oral disease characterized by loss of alveolar bone and progressive teeth loss, is the sixth major complication of diabetes. It is spreading worldwide as it is difficult to be cured. Th...

Authors: Rongrong Jiang, Miao Wang, Xiaobo Shen, Shuai Huang, Jianpeng Han, Lei Li, Zhiliang Xu, Chengfeng Jiang, Qiao Zhou and Xingmei Feng

Label-free separation of neuroblastoma patient-derived xenograft (PDX) cells from hematopoietic progenitor cell products by acoustophoresis

Graft-contaminating tumor cells correlate with inferior outcome in high-risk neuroblastoma patients undergoing hematopoietic stem cell transplantation and can contribute to relapse. Motivated by the potential ...

Authors: Franziska Olm, Lena Panse, Josefina H. Dykes, Daniel Bexell, Thomas Laurell and Stefan Scheding

Endometrial regenerative cells with galectin-9 high-expression attenuate experimental autoimmune hepatitis

Autoimmune hepatitis (AIH) is a T cell-mediated immune disease that activates abnormally against hepatic antigens. We have previously reported that endometrial regenerative cells (ERCs) were a novel source of ...

Authors: Hongda Wang, Yiming Zhao, Bingbing Ren, Yafei Qin, Guangming Li, Dejun Kong, Hong Qin, Jingpeng Hao, Daqing Sun and Hao Wang

CM from intact hAM: an easily obtained product with relevant implications for translation in regenerative medicine

It is now well established that factors (free or in extracellular vesicles) secreted by mesenchymal stromal cells (MSC) are important mediators of MSC regenerative actions. Herein we produced the secretome (co...

Authors: Antonietta Rosa Silini, Andrea Papait, Anna Cargnoni, Elsa Vertua, Pietro Romele, Patrizia Bonassi Signoroni, Marta Magatti, Silvia De Munari, Alice Masserdotti, Anna Pasotti, Sara Rota Nodari, Giorgio Pagani, Mario Bignardi and Ornella Parolini

Mesenchymal stem/stromal cell therapy in atopic dermatitis and chronic urticaria: immunological and clinical viewpoints

Allergic diseases are immune-mediated diseases. Allergies share a common immunopathogenesis, with specific differences according to the specific disease. Mesenchymal stem/stromal cells (MSCs) have been applied...

Authors: Eun-Young Kim, Hyuk Soon Kim, Ki-Sung Hong, Hyung-Min Chung, Se-Pill Park and Geunwoong Noh

Cell-based therapies for retinal diseases: a review of clinical trials and direct to consumer “cell therapy” clinics

The retinal pigment epithelium (RPE) is implicated in the pathophysiology of many retinal degenerative diseases. This cell layer is also an ideal target for cell-based therapies. Several early phase clinical t...

Authors: John W. Hinkle, Raziyeh Mahmoudzadeh and Ajay E. Kuriyan

Human adipose-derived stromal cells transplantation prolongs reproductive lifespan on mouse models of mild and severe premature ovarian insufficiency

Although recent studies have investigated the ability of Mesenchymal Stromal Cells (MSCs) to alleviate short-term ovarian damage in animal models of chemotherapy-induced Premature Ovarian Insufficiency (POI), ...

Authors: Giulia Salvatore, Massimo De Felici, Susanna Dolci, Cosimo Tudisco, Rosella Cicconi, Luisa Campagnolo, Antonella Camaioni and Francesca Gioia Klinger

Endometrial mesenchymal stem/stromal cells: The Enigma to code messages for generation of functionally active regulatory T cells

Regulatory T cells (Tregs) play an important role in fine-tuning of immune responses and are pivotal for a successful pregnancy. Recently, the importance of mesenchymal stem cells in regulation of immune respo...

Authors: Mehdi Aleahmad, Mahmood Bozorgmehr, Shohreh Nikoo, Alireza Ghanavatinejad, Mohammad-Reza Shokri, Samaneh Montazeri, Fazel Shokri and Amir-Hassan Zarnani

sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis

Tumor necrosis factor (TNF)-α inhibitors represented by Etanercept (a fusion protein containing soluble TNF receptor II (sTNFRII) and the Fc segment of human IgG1) play a pivotal role in Rheumatoid arthritis (...

Authors: Yingjie Zhao, Xuezhi Yang, Siyu Li, Bingjie Zhang, Susu Li, Xinwei Wang, Yueye Wang, Chengyan Jia, Yan Chang and Wei Wei

A novel minimally invasive OFM technique with orthotopic transplantation of hUC-MSCs and in vivo monitoring of liver metabolic microenvironment in liver fibrosis treatment

Mesenchymal stromal cells (MSCs) transplantation showed promising therapeutic results in liver fibrosis. However, efficient cell delivery method is urgently needed and the therapeutic mechanism remains unclear...

Authors: Hui Yang, Yuanyuan Xie, Tuo Li, Shuo Liu, Sheng Zeng and Bin Wang

Non-stem bladder cancer cell-derived extracellular vesicles promote cancer stem cell survival in response to chemotherapy

Chemosenstive non-stem cancer cells (NSCCs) constitute the bulk of tumors and are considered as part of the cancer stem cell (CSC) niche in the tumor microenvironment (TME). Tumor-derived extracellular vesicle...

Authors: Wei-Min Chung, Ryan D. Molony and Yi-Fen Lee

Mesenchymal stem cells derived from human induced pluripotent stem cells improve the engraftment of myogenic cells by secreting urokinase-type plasminogen activator receptor (uPAR)

Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disease caused by mutations in the dystrophin gene. Transplantation of myogenic stem cells holds great promise for treating muscular dystrophies. H...

Authors: Ahmed Elhussieny, Ken’ichiro Nogami, Fusako Sakai-Takemura, Yusuke Maruyama, Natsumi Takemura, Wael Talaat Soliman, Shin’ichi Takeda and Yuko Miyagoe-Suzuki

SPION-MSCs enhance therapeutic efficacy in sepsis by regulating MSC-expressed TRAF1-dependent macrophage polarization

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. The liver has a crucial role in sepsis and is also a target for sepsis-related injury. Macrophage ...

Authors: Yujun Xu, Xinghan Liu, Yi Li, Huan Dou, Huaping Liang and Yayi Hou

Therapeutic effects of mesenchymal stem cells-derived extracellular vesicles’ miRNAs on retinal regeneration: a review

Extracellular vesicles (EVs), which consist of microvesicles and exosomes, are secreted from all cells to transform vital information in the form of lipids, proteins, mRNAs and small RNAs such as microRNAs (mi...

Authors: Ali Rajool Dezfuly, Azadeh Safaee and Hossein Salehi

Retraction Note to: MiR-34a inhibitor protects mesenchymal stem cells from hyperglycaemic injury through the activation of the SIRT1/FoxO3a autophagy pathway

Authors: Fengyun Zhang, Fei Gao, Kun Wang, Xiaohong Liu and Zhuoqi Zhang

Longitudinal clonal tracking in humanized mice reveals sustained polyclonal repopulation of gene-modified human-HSPC despite vector integration bias

Current understanding of hematopoiesis is largely derived from mouse models that are physiologically distant from humans. Humanized mice provide the most physiologically relevant small animal model to study hu...

Authors: Gajendra W. Suryawanshi, Hubert Arokium, Sanggu Kim, Wannisa Khamaikawin, Samantha Lin, Saki Shimizu, Koollawat Chupradit, YooJin Lee, Yiming Xie, Xin Guan, Vasantika Suryawanshi, Angela P. Presson, Dong-Sung An and Irvin S. Y. Chen

CAR-T cell therapy in T-cell malignancies: Is success a low-hanging fruit?

Chimeric antigen receptor T-cell (CAR-T) therapy has been prosperous in the treatment of patients with various types of relapsed/refractory (R/R) B-cell malignancies including diffuse large B-cell lymphoma (DL...

Authors: Pouya Safarzadeh Kozani, Pooria Safarzadeh Kozani and Fatemeh Rahbarizadeh

Additional benefit of induced pluripotent stem cell-derived mesenchymal stem cell therapy on sepsis syndrome-associated acute kidney injury in rat treated with antibiotic

This study tested whether human induced-pluripotent stem-cell-derived mesenchymal-stem-cells (iPS-MSCs) would offer an additional benefit to the rodent with acute kidney injury (AKI) (ischemia for 1 h followed...

Authors: Chih-Chao Yang, Pei‐Hsun Sung, Chih-Hung Chen, John Y. Chiang, Pei-Lin Shao, Shun-Cheng Wu and Hon‐Kan Yip

Knockdown of SERPINB2 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signalling pathway

Globally, bone fractures are the most common musculoskeletal trauma, and approximately 8–10% of cases that fall into the categories of delayed or non-union healing. To date, there are no efficient pharmacologi...

Authors: Kai Hang, Li Ying, Jinwu Bai, Yibo Wang, Zhihui Kuang, Deting Xue and Zhijun Pan

Long-term survival of cultivated oral mucosal epithelial cells in human cornea: generating cell sheets using an animal product-free culture protocol

Previously, we reported a collagenase-based, animal product-free protocol for cultivated oral mucosal epithelial cell sheets for transplantation (COMET). Here, we reported the long-term outcomes of first 2 cli...

Authors: David Hui-Kang Ma, Yi-Jen Hsueh, Kevin Sheng-Kai Ma, Yueh-Ju Tsai, Shiang-Fu Huang, Hung-Chi Chen, Chi-Chin Sun, Ming-Tse Kuo, An-Shine Chao and Jui-Yang Lai

Regulation of the integrin αVβ3- actin filaments axis in early osteogenesis of human fibroblasts under cyclic tensile stress

Integrins play a prominent role in osteogenic differentiation by transmitting both mechanical and chemical signals. Integrin expression is closely associated with tensile stress, which has a positive effect on...

Authors: Yan Peng, Rongmei Qu, Yanting Feng, Xiaolan Huang, Yuchao Yang, Tingyu Fan, Bing Sun, Asmat Ullah Khan, Shutong Wu, Jingxing Dai and Jun Ouyang

Correction to: The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury

Authors: Fangxia Guan, Tuanjie Huang, Xinxin Wang, Qu Xing, Kristyn Gumpper, Peng Li, Jishi Song, Tao Tan, Greta Luyuan Yang, Xingxing Zang, Jiewen Zhang, Yuming Wang, Yunlei Yang, Yashi Liu, Yanting Zhang, Bo Yang…

Applications, challenges and prospects of mesenchymal stem cell exosomes in regenerative medicine

Recent advances in the identification and application of different stem cell types have offered alternative therapeutic approaches for clinicians. The lack of successful engraftment, migration into the injured...

Authors: Aysa Rezabakhsh, Emel Sokullu and Reza Rahbarghazi

Novel culture media enhances mononuclear cells from patients with chronic limb-threatening ischemia to increase vasculogenesis and anti-inflammatory effect

Quality and Quantity culture media (QQ culture media) was reported to enhance vasculogenesis and angiogenesis function of mononuclear cells (MNCs) from healthy volunteers. In this study, MNCs from chronic limb...

Authors: Nuttapol Chruewkamlow, Kanin Pruekprasert, Phakawan Phutthakunphithak, Onchira Acharayothin, Tossapol Prapassaro, Kiattisak Hongku, Suteekhanit Hahtapornsawan, Nattawut Puangpunngam, Khamin Chinsakchai, Chumpol Wongwanit, Chanean Ruangsetakit and Nuttawut Sermsathanasawadi

Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-inflammation and macrophage polarization via NF-κB signaling pathway and Nrf2/HO-1 axis

Exosomes are considered a substitute for stem cell-based therapy for myocardial infarction (MI). FNDC5, a transmembrane protein located in the cytoplasm, plays a crucial role in inflammation diseases and MI re...

Authors: Hongjuan Ning, Haixu Chen, Jingyu Deng, Chun Xiao, Moyan Xu, Lina Shan, Chao Yang and Zheng Zhang

Management of toxic optic neuropathy via a combination of Wharton’s jelly-derived mesenchymal stem cells with electromagnetic stimulation

To investigate the effect of the combination of Wharton's jelly derived mesenchymal stem cells (WJ-MSC) and high frequency repetitive electromagnetic stimulation (rEMS) in the therapy of toxic optic neuropathi...

Authors: Emin Özmert and Umut Arslan

Bone marrow-derived mesenchymal stem cells combined with gonadotropin therapy restore postnatal oogenesis of chemo-ablated ovaries in rats via enhancing very small embryonic-like stem cells

Very small embryonic-like stem cells (VSELs) are a rare population within the ovarian epithelial surface. They contribute to postnatal oogenesis as they have the ability to generate immature oocytes and resist...

Authors: Nesrine Ebrahim, Hajir A. Al Saihati, Amani Shaman, Arigue A. Dessouky, Ayman Samir Farid, Noha I. Hussien, Ola Mostafa, Yasmin Seleem, Dina Sabry, Ahmed S. Saad, Hanan Tawfeek Emam, Amira Hassouna, Omnia A. M. Badr, Bayan A. Saffaf, Nicholas R. Forsyth and Rabab F. Salim

Evaluation of the effect of donor weight on adipose stromal/stem cell characteristics by using weight-discordant monozygotic twin pairs

Adipose stromal/stem cells (ASCs) are promising candidates for future clinical applications. ASCs have regenerative capacity, low immunogenicity, and immunomodulatory ability. The success of future cell-based ...

Authors: Miia Juntunen, Sini Heinonen, Heini Huhtala, Aila Rissanen, Jaakko Kaprio, Kirsi Kuismanen, Kirsi H. Pietiläinen, Susanna Miettinen and Mimmi Patrikoski

Therapeutic approach of adipose-derived mesenchymal stem cells in refractory peptic ulcer

Peptic ulcer is one of the most common gastrointestinal tract disorders worldwide, associated with challenges such as refractory morbidity, bleeding, interference with use of anticoagulants, and potential side...

Authors: Mahshid Saleh, Amir Ali Sohrabpour, Mohammad Reza Mehrabi, Iman Seyhoun and Amir Abbas Vaezi

IL-1β-primed mesenchymal stromal cells exert enhanced therapeutic effects to alleviate Chronic Prostatitis/Chronic Pelvic Pain Syndrome through systemic immunity

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) seriously affects patient health. Despite the elusiveness of innate therapeutic effects, mesenchymal stromal cells (MSCs) hold great promise for infla...

Authors: Hanchao Liu, Xinning Zhu, Xiaohui Cao, Ani Chi, Jian Dai, Zhenqing Wang, Chunhua Deng and Min Zhang

Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects

Bones have a remarkable capacity to heal upon fracture. Yet, in large defects or compromised conditions healing processes become impaired, resulting in delayed or non-union. Current therapeutic approaches ofte...

Authors: Wai Long Tam, Luís Freitas Mendes, Xike Chen, Raphaëlle Lesage, Inge Van Hoven, Elke Leysen, Greet Kerckhofs, Kathleen Bosmans, Yoke Chin Chai, Akihiro Yamashita, Noriyuki Tsumaki, Liesbet Geris, Scott J. Roberts and Frank P. Luyten

Transplantation of mesenchymal stem cells ameliorates systemic lupus erythematosus and upregulates B10 cells through TGF-β1

Considerable experimental and clinical evidences have proved that human umbilical cord mesenchymal stem cells (UC-MSCs) transplantation was powerful in systemic lupus erythematosus (SLE) treatment. MSCs could ...

Authors: Wang Chun, Jilai Tian and Ying Zhang

Contrast agents for photoacoustic imaging: a review of stem cell tracking

With the advent of stem cell therapy for spinal cord injuries, stroke, burns, macular degeneration, heart diseases, diabetes, rheumatoid arthritis and osteoarthritis; the need to track the survival, migration ...

Authors: Soorya James, Kai Neuhaus, Mary Murphy and Martin Leahy

AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation

Phosphoinositide-3 kinase (PI3K)/AKT signaling participates in cellular proliferation, survival and tumorigenesis. The activation of AKT signaling promotes the cellular reprogramming including generation of in...

Authors: Yoichi Sekita, Yuki Sugiura, Akari Matsumoto, Yuki Kawasaki, Kazuya Akasaka, Ryo Konno, Momoka Shimizu, Toshiaki Ito, Eiji Sugiyama, Terushi Yamazaki, Eriko Kanai, Toshinobu Nakamura, Makoto Suematsu, Fumitoshi Ishino, Yoshio Kodera, Takashi Kohda…

Correction to: Adult bone marrow mesenchymal and neural crest stem cells are chemoattractive and accelerate motor recovery in a mouse model of spinal cord injury

Authors: Virginie Neirinckx, Gulistan Agirman, Cécile Coste, Alice Marquet, Valérie Dion, Bernard Rogister, Rachelle Franzen and Sabine Wislet

In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells-derived dopaminergic neurons carrying LRRK2 p.G2019S mutation

The c.G6055A (p.G2019S) mutation in leucine-rich repeat kinase 2 (LRRK2) is the most prevalent genetic cause of Parkinson’s disease (PD). CRISPR/Cas9-mediated genome editing by homology-directed repair (HDR) has ...

Authors: Kuo-Hsuan Chang, Cheng-Yen Huang, Chih-Hsin Ou-Yang, Chang-Han Ho, Han-Yi Lin, Chia-Lang Hsu, You-Tzung Chen, Yu-Chi Chou, Yi-Jing Chen, Ying Chen, Jia-Li Lin, Ji-Kuan Wang, Pei-Wen Lin, Ying-Ru Lin, Miao-Hsia Lin, Chi-Kang Tseng…

Salvianolic acid-B improves fat graft survival by promoting proliferation and adipogenesis

Our previous study proved that Salvia miltiorrhiza could enhance fat graft survival by promoting adipogenesis. However, the effect of salvianolic acid B (Sal-B), the most abundant and bioactive water-soluble comp...

Authors: Jia-Ming Sun, Chia-Kang Ho, Ya Gao, Chio-Hou Chong, Dan-Ning Zheng, Yi-Fan Zhang and Li Yu

Human bone marrow-derived mesenchymal stromal cells cultured in serum-free media demonstrate enhanced antifibrotic abilities via prolonged survival and robust regulatory T cell induction in murine bleomycin-induced pulmonary fibrosis

Mesenchymal stromal cells (MSCs) are a potential therapeutic tool for pulmonary fibrosis. However, ex vivo MSC expansion using serum poses risks of harmful immune responses or unknown pathogen infections in th...

Authors: Shun Takao, Taku Nakashima, Takeshi Masuda, Masashi Namba, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Shinya Takahashi, Ayumu Nakashima and Noboru Hattori

Sympathetic activity is correlated with satellite cell aging and myogenesis via β2-adrenoceptor

Sympathetic activity plays an important role in the proliferation and differentiation of stem cells, and it changes over time, thereby exerting differential effects on various stem cell types. Aging causes sym...

Authors: Shiguo Yuan, Sheng Zheng, Kai Zheng, Yanping Gao, Meixiong Chen, Yikai Li and Xiaochun Bai

Extracellular vesicles derived from mesenchymal stem cells as a potential therapeutic agent in acute kidney injury (AKI) in felines: review and perspectives

Mesenchymal stem cells (MSCs), known from their key role in the regeneration process of tissues, and their abilities to release bioactive factors like extracellular vesicles (EVs) could be considered as a pote...

Authors: Magdalena M. Kraińska, Natalia Pietrzkowska, Eliza Turlej, Li Zongjin and Krzysztof Marycz

The effect of genetically modified platelet-derived growth factor-BB over-expressing mesenchymal stromal cells during core decompression for steroid-associated osteonecrosis of the femoral head in rabbits

Approximately one third of patients undergoing core decompression (CD) for early-stage osteonecrosis of the femoral head (ONFH) experience progression of the disease, and subsequently require total hip arthrop...

Authors: Roberto Alfonso Guzman, Masahiro Maruyama, Seyedsina Moeinzadeh, Elaine Lui, Ning Zhang, Hunter W. Storaci, Kaysie Tam, Elijah Ejun Huang, Takeshi Utsunomiya, Claire Rhee, Qi Gao, Zhenyu Yao, Yunzhi Peter Yang and Stuart B. Goodman

Chronic inflammation-induced senescence impairs immunomodulatory properties of synovial fluid mesenchymal stem cells in rheumatoid arthritis

Although the immunomodulatory properties of mesenchymal stem cells (MSCs) have been highlighted as a new therapy for autoimmune diseases, including rheumatoid arthritis (RA), the disease-specific characteristi...

Authors: Hyeon-Jeong Lee, Won-Jae Lee, Sun-Chul Hwang, Yongho Choe, Saetbyul Kim, Eunyeong Bok, Sangyeob Lee, Seung-Joon Kim, Hyun-Ok Kim, Sun-A Ock, Hae-Sook Noh, Gyu-Jin Rho, Sang-Il Lee and Sung-Lim Lee

Human amniotic stem cells-derived exosmal miR-181a-5p and miR-199a inhibit melanogenesis and promote melanosome degradation in skin hyperpigmentation, respectively

Hyperpigmentation of skin is caused by an imbalance between the melanosome/melanin synthesis in melanocytes and the melanosome/melanin degradation in keratinocytes. Although studies showed that stem cells play...

Authors: Xiao-Yu Wang, Xiao-Hui Guan, Zhen-Ping Yu, Jie Wu, Qi-Ming Huang, Ke-Yu Deng and Hong-Bo Xin