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  1. Age-related macular degeneration (AMD) is a highly prevalent form of blindness caused by loss death of cells of the retinal pigment epithelium (RPE). Transplantation of pluripotent stem cell (PSC)-derived RPE ...

    Authors: Ioannis J. Limnios, Yu-Qian Chau, Stuart J. Skabo, Denver C. Surrao and Helen C. O’Neill

    Citation: Stem Cell Research & Therapy 2021 12:248

    Content type: Research

    Published on:

  2. Tear deficiency due to lacrimal gland (LG) dysfunction is one of the major causes of dry eye disease (DED). Therefore, LG stem cell-based therapies have been extensively reported to regenerate injured lacrimal...

    Authors: Sang Yun Jeong, Woo Hee Choi, Seong Gyeong Jeon, Sookon Lee, Jong-Moon Park, Mira Park, Hookeun Lee, Helen Lew and Jongman Yoo

    Citation: Stem Cell Research & Therapy 2021 12:247

    Content type: Research

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  3. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is life-saving for severe hematological conditions. However, its outcomes need further improvement, and co-infusion of mesenchymal stem cells (MSC...

    Authors: Teng Li, Chengxin Luo, Jiasi Zhang, Ling Wei, Wei Sun, Qin Xie, Yan Liu, Yongli Zhao, Shuangnian Xu and Lihua Wang

    Citation: Stem Cell Research & Therapy 2021 12:246

    Content type: Research

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  5. ABO-incompatible liver transplantation (ABO-i LT) has become a rescue therapeutic option for patients with severe hepatic failure. Although the use of rituximab greatly reduces the morbidity of antibody-mediat...

    Authors: Yingcai Zhang, Jiebin Zhang, Huimin Yi, Jun Zheng, Jianye Cai, Wenjie Chen, Tongyu Lu, Liang Chen, Cong Du, Jianrong Liu, Jia Yao, Hui Zhao, Guoying Wang, Binsheng Fu, Tong Zhang, Jian Zhang…

    Citation: Stem Cell Research & Therapy 2021 12:244

    Content type: Research

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  6. The regeneration response of the skin to mechanical stretching in vivo has been explored in reconstructive surgery to repair large-scale deformities. The ability of the skin to regenerate limits the reconstruc...

    Authors: Poh-Ching Tan, Pei-Chuan Chao, Chen Cheng, Chu-Hsin Chen, Ru-Lin Huang, Shuang-Bai Zhou, Yun Xie and Qing-Feng Li

    Citation: Stem Cell Research & Therapy 2021 12:243

    Content type: Research

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  7. Human dental follicle cells (DFCs) are the precursor cells of the periodontium with a high potential for regenerative therapies of (alveolar) bone. However, the molecular mechanisms of osteogenic differentiati...

    Authors: Oliver Pieles, Torsten E. Reichert and Christian Morsczeck

    Citation: Stem Cell Research & Therapy 2021 12:242

    Content type: Research

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  8. The in vitro expansion and differentiation of mesenchymal stem cells derived from bone marrow (BM-hMSCs) are considered as potential therapeutic tools for clinical applications in bone tissue engineering and r...

    Authors: Naruphong Phunikom, Nittaya Boonmuen, Pakpoom Kheolamai, Kanoknetr Suksen, Sirikul Manochantr, Chairat Tantrawatpan and Duangrat Tantikanlayaporn

    Citation: Stem Cell Research & Therapy 2021 12:241

    Content type: Research

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  9. Atherosclerotic renal artery stenosis (ARAS) is a risk factor for ischemic and hypertensive kidney disease (HKD) for which autologous mesenchymal stem cell (MSC) appears to be a promising therapy. However, MSC...

    Authors: Busra Isik, Roman Thaler, Busra B. Goksu, Sabena M. Conley, Hayder Al-Khafaji, Arjunmohan Mohan, Mohsen Afarideh, Abdelrhman M. Abumoawad, Xiang Y. Zhu, James D. Krier, Ishran M. Saadiq, Hui Tang, Alfonso Eirin, LaTonya J. Hickson, Andre J. van Wijnen, Stephen C. Textor…

    Citation: Stem Cell Research & Therapy 2021 12:240

    Content type: Research

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  10. Adipose-derived stem cell (ADSC) is one of the most widely used candidate cell for intervertebral disc (IVD) degeneration-related disease. However, the poor survival and low differentiation efficacy in stresse...

    Authors: Zemin Zhu, Hongyuan Xing, Ruofu Tang, Shengjun Qian, Shaoqi He, Qiang Hu and Ning Zhang

    Citation: Stem Cell Research & Therapy 2021 12:239

    Content type: Research

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  11. Immunosuppressive ability in human MSC donors has been shown to be variable and may be a limiting factor in MSC therapeutic efficacy in vivo. The importance of cytokine activation of mesenchymal stromal cells ...

    Authors: Jennifer M. Corbett, Ian Hawthorne, Hazel Dunbar, Ivan Coulter, Mairead Ni Chonghaile, Catherine M. Flynn and Karen English

    Citation: Stem Cell Research & Therapy 2021 12:238

    Content type: Research

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  12. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13287-019-1149-5.

    Authors: Zhanjun Ma, Xue Cui, Li Lu, Guohu Chen, Yang Yang, Yan Hu, Yubao Lu, Zhangqi Cao, Yan Wang and Xuexi Wang

    Citation: Stem Cell Research & Therapy 2021 12:237

    Content type: Retraction Note

    Published on:

    The original article was published in Stem Cell Research & Therapy 2019 10:60

  13. Erythro-myeloid progenitors (EMP) are found in a population of cells expressing CD31 and CD45 markers (CD31+CD45+). A recent study indicated that EMPs persist until adulthood and can be a source of endothelial ce...

    Authors: Maria Chiara G. Monaco, Dragan Maric, Ombretta Salvucci, Cristina Antonetti Lamorgese Passeri, Patrizia Accorsi, Eugene O. Major and Anna Concetta Berardi

    Citation: Stem Cell Research & Therapy 2021 12:236

    Content type: Letter

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  14. Vascular calcification associated with chronic kidney disease (CKD) can increase the risk of mortality. Elevated serum levels of high mobility group box 1 (HMGB1) promotes vascular calcification in CKD via the...

    Authors: Wenqian Wei, Xiaodong Guo, Lijie Gu, Jieshuang Jia, Man Yang, Weijie Yuan and Shu Rong

    Citation: Stem Cell Research & Therapy 2021 12:235

    Content type: Research

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  15. The repair of critical-sized bone defects is always a challenging problem. Electromagnetic fields (EMFs), used as a physiotherapy for bone defects, have been suspected to cause potential hazards to human healt...

    Authors: Weigang Li, Wenbin Liu, Wei Wang, Jiachen Wang, Tian Ma, Jingyuan Chen, Hua Wu and Chaoxu Liu

    Citation: Stem Cell Research & Therapy 2021 12:234

    Content type: Research

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  16. iPSC (induced pluripotent stem cells) banks of iPSC lines with homozygous HLA (human leukocyte antigen) haplotypes (haplobanks) are proposed as an affordable and off-the-shelf approach to allogeneic transplant...

    Authors: Belén Álvarez-Palomo, Iris García-Martinez, Jorge Gayoso, Angel Raya, Anna Veiga, María Luisa Abad, Adolfo Eiras, María Guzmán-Fulgencio, Mar Luis-Hidalgo, Cristina Eguizabal, Silvia Santos, Antonio Balas, Raquel Alenda, Francisco Sanchez-Gordo, Laura Ponce Verdugo, Juliana Villa…

    Citation: Stem Cell Research & Therapy 2021 12:233

    Content type: Research

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  17. Asymmetrical cell division (ACD) maintains the proper number of stem cells to ensure self-renewal. The rate of symmetric division increases as more cancer stem cells (CSCs) become malignant; however, the signa...

    Authors: Mi Chen, Chenxia Lu, Hanwen Lu, Junyi Zhang, Dan Qin, Shenghui Liu, Xiaodong Li and Lisheng Zhang

    Citation: Stem Cell Research & Therapy 2021 12:232

    Content type: Research

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  18. Direct bone marrow injection of cells into murine marrow cavities is used in a range of cell characterization assays and to develop disease models. While human bone marrow-derived stromal cells (hBMSC, also kn...

    Authors: Bianca Nowlan, Kathryn Futrega, Elizabeth Deborah Williams and Michael Robert Doran

    Citation: Stem Cell Research & Therapy 2021 12:231

    Content type: Research

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  19. Pulmonary fibrosis (PF), the end point of interstitial lung diseases, is characterized by myofibroblast over differentiation and excessive extracellular matrix accumulation, leading to progressive organ dysfun...

    Authors: Liyan Shi, Jing Ren, Jiping Li, Dongxu Wang, Yusu Wang, Tao Qin, Xiuying Li, Guokun Zhang, Chunyi Li and Yimin Wang

    Citation: Stem Cell Research & Therapy 2021 12:230

    Content type: Research

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  20. Stem cells have been introduced as new promising therapeutic agents in treatment of degenerative diseases because of having high differentiation potential while maintaining the ability to self-replicate and re...

    Authors: Rano Zhankina, Neda Baghban, Manarbek Askarov, Dana Saipiyeva, Almaz Ibragimov, Bakhyt Kadirova, Arezoo Khoradmehr, Iraj Nabipour, Reza Shirazi, Ulanbek Zhanbyrbekuly and Amin Tamadon

    Citation: Stem Cell Research & Therapy 2021 12:229

    Content type: Review

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  21. Adult mesenchymal stem cells (MSCs) have been studied extensively for regenerative medicine; however, they have limited proliferation in vitro, and the long culture time induces cell senescence. MSCs also cont...

    Authors: Guobing Zhuang, Yan Wen, Mason Briggs, Qingchun Shao, Darlene Tran, Hongbo Wang and Bertha Chen

    Citation: Stem Cell Research & Therapy 2021 12:228

    Content type: Research

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  22. Systemic administration of mesenchymal stromal cells (MSCs) has been efficacious in many inflammatory disease settings; however, little data are available on the potential immunomodulatory effects following lo...

    Authors: Oliver Treacy, Kevin Lynch, Nick Murphy, Xizhe Chen, Ellen Donohoe, Aoife Canning, Paul Lohan, Georgina Shaw, Gerry Fahy, Aideen E. Ryan and Thomas Ritter

    Citation: Stem Cell Research & Therapy 2021 12:227

    Content type: Short report

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  23. Wound healing is impaired in patients with diabetes due to the multifactorial etiology of the disease, which limits the therapeutic efficacy of various approaches. This study hypothesizes that the combination ...

    Authors: Xuejun Ni, Xiuying Shan, Lili Xu, Wenjun Yu, Mingliang Zhang, Chen Lei, Nating Xu, Junyu Lin and Biao Wang

    Citation: Stem Cell Research & Therapy 2021 12:226

    Content type: Research

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  24. Premature exfoliation of the deciduous teeth is a common manifestation in childhood patients with hypophosphatasia (HPP), which is an autosomal inherited disease caused by ALPL mutations. Dysplasia of the ceme...

    Authors: Liqiang Zhang, Jiangdong Zhao, Jiayi Dong, Yuting Liu, Kun Xuan and Wenjia Liu

    Citation: Stem Cell Research & Therapy 2021 12:225

    Content type: Research

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  25. Exosomes derived from the bone marrow mesenchymal stem cell (MSC) have shown great potential in spinal cord injury (SCI) treatment. This research was designed to investigate the therapeutic effects of miR-26a-...

    Authors: Yuyong Chen, Zhenming Tian, Lei He, Can Liu, Nangxiang Wang, Limin Rong and Bin Liu

    Citation: Stem Cell Research & Therapy 2021 12:224

    Content type: Research

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  26. Human amniotic epithelial cells (hAECs) exhibit a strong capability to restore ovarian function in chemotherapy-induced premature ovarian failure (POF). However, the therapeutic efficacy of hAECs is usually af...

    Authors: Yating Huang, Zhijie Ma, Xiaojun Kuang, Qiuwan Zhang, Haiyan Li and Dongmei Lai

    Citation: Stem Cell Research & Therapy 2021 12:223

    Content type: Research

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  27. To explore the adipogenic effects of the small extracellular vesicles derived from the lipoma tissues (sEV-LT), and to find a new cell-free therapeutic approach for adipose tissue regeneration.

    Authors: Pengyu Hong, Xiaoyang Xu, Xin Hu, Hao Yang, Yue Wu, Juan Chen, Kun Li and Zhangui Tang

    Citation: Stem Cell Research & Therapy 2021 12:222

    Content type: Research

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  28. Hypertrophic scar (HS) is a fibro-proliferative disorder of dermis after burn or trauma and usually leads to esthetic disfiguration and functionary impairment for patients. Emerging evidences demonstrated ADSC...

    Authors: Yan Li, Jian Zhang, Jihong Shi, Kaituo Liu, Xujie Wang, Yanhui Jia, Ting He, Kuo Shen, Yunchuan Wang, Jiaqi Liu, Wei Zhang, Tongtao Wang, Zhao Zheng and Dahai Hu

    Citation: Stem Cell Research & Therapy 2021 12:221

    Content type: Research

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  29. Mesenchymal stem cells (MSCs) exert positive effects in chronic wounds. However, critical parameters, such as the most effective administration routes, remain unclear. Accordingly, the purpose of this study wa...

    Authors: Jianxin Yan, Jiaji Liang, Yingxuan Cao, Mariya M. El Akkawi, Xuan Liao, Xiaojia Chen, Chengzhi Li, Kecheng Li, Guanghui Xie and Hongwei Liu

    Citation: Stem Cell Research & Therapy 2021 12:220

    Content type: Research

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  31. Hepatic ischaemia-reperfusion injury (HIRI) is inevitable in complicated liver surgery and is a major factor leading to postoperative complications and liver dysfunction. Studies have shown that the paracrine ...

    Authors: Zhihui Jiao, Yajun Ma, Qianzhen Zhang, Yue Wang, Tao Liu, Xiaoning Liu, Chenxi Piao, Boyang Liu and Hongbin Wang

    Citation: Stem Cell Research & Therapy 2021 12:218

    Content type: Research

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  32. Despite many recent advances on cancer novel therapies, researchers have yet a long way to cure cancer. They have to deal with tough challenges before they can reach success. Nonetheless, it seems that recentl...

    Authors: Faroogh Marofi, Safa Tahmasebi, Heshu Sulaiman Rahman, Denis Kaigorodov, Alexander Markov, Alexei Valerievich Yumashev, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Rebar N. Mohammed, Mostafa Jarahian, Roza Motavalli and Farhad Motavalli Khiavi

    Citation: Stem Cell Research & Therapy 2021 12:217

    Content type: Review

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  33. Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are syndromes of acute respiratory failure with extremely high mortality and few effective treatments. Mesenchymal stem cells (MSCs) may r...

    Authors: Wenjun Peng, Meijia Chang, Yuanyuan Wu, Wensi Zhu, Lin Tong, Ge Zhang, Qin Wang, Jie Liu, Xiaoping Zhu, Tingting Cheng, Yijia Li, Xi Chen, Dong Weng, Sanhong Liu, Hongwei Zhang, Yao Su…

    Citation: Stem Cell Research & Therapy 2021 12:216

    Content type: Research

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  34. Dysfunction of mesenchymal stem cells (MSCs) is recognized as critical to the pathogenesis of glucocorticoid-induced osteoporosis (GIO), suggesting the potential of MSC-targeting interventions for this disorde...

    Authors: Gang Wang, Fengbin Wang, Lecheng Zhang, Chao Yan and Yuelei Zhang

    Citation: Stem Cell Research & Therapy 2021 12:215

    Content type: Research

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  35. The corneal endothelium maintains corneal hydration through the barrier and pump function, while its dysfunction may cause corneal edema and vision reduction. Considering its development from neural crest cell...

    Authors: Yajie Gong, Haoyun Duan, Xin Wang, Can Zhao, Wenjing Li, Chunxiao Dong, Zongyi Li and Qingjun Zhou

    Citation: Stem Cell Research & Therapy 2021 12:214

    Content type: Research

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  36. Hepatic fibrosis is a common complication in transfusion-dependent thalassemia patients. Data on the co-transplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) in beta-thalassemia...

    Authors: Tahereh Rostami, Amir Kasaeian, Nasrollah Maleki, Mohsen Nikbakht, Azadeh Kiumarsi, Seyed Mohammad Tavangar, Amir Pejman Hashemi Taheri, Seied Asadollah Mousavi and Ardeshir Ghavamzadeh

    Citation: Stem Cell Research & Therapy 2021 12:213

    Content type: Research

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  38. The adoptive transfer of natural killer (NK) cells is an emerging therapy in the field of immuno-oncology. In the last 3 decades, NK cells have been utilized to harness the anti-tumor immune response in a wide...

    Authors: Margaret G. Lamb, Hemalatha G. Rangarajan, Brian P. Tullius and Dean A. Lee

    Citation: Stem Cell Research & Therapy 2021 12:211

    Content type: Review

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  39. Stem cells are characterized by their self-renewal and multipotency and have great potential in the therapy of various disorders. However, the blood–brain barrier (BBB) limits the application of stem cells in ...

    Authors: Yu-Ting Zhang, Kai-Jie He, Jin-Bao Zhang, Quan-Hong Ma, Fen Wang and Chun-Feng Liu

    Citation: Stem Cell Research & Therapy 2021 12:210

    Content type: Review

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  40. Several studies have confirmed that mobilizing bone marrow-derived stem cells (BMSCs) ameliorates renal function loss following cisplatin-induced acute kidney injury (AKI). The aim of this study was to explore...

    Authors: Zhi Chen, Xiang Ren, Ruimin Ren, Yonghong Wang and Jiwen Shang

    Citation: Stem Cell Research & Therapy 2021 12:209

    Content type: Research

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  41. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold great promise for regenerative medicine and in drugs screening. Despite displaying key cardiomyocyte phenotypic characteristics, they...

    Authors: Xinyuan Zhang, Liang Ye, Hao Xu, Qin Zhou, Bin Tan, Qin Yi, Liang Yan, Min Xie, Yin Zhang, Jie Tian and Jing Zhu

    Citation: Stem Cell Research & Therapy 2021 12:208

    Content type: Research

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  42. Cesarean scar defect (CSD) is characterized by the presence of fibrotic tissue and decreased muscular density which is induced by cesarean section. Serious CSD may eventually result in infertility or obstetric...

    Authors: Yihui Fan, Junyan Sun, Qiuwan Zhang and Dongmei Lai

    Citation: Stem Cell Research & Therapy 2021 12:207

    Content type: Research

    Published on:

  43. Glioblastoma (GBM) is the highest-grade form of glioma, as well as one of the most aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior. Despite significant advances in dia...

    Authors: Ana Laura V. Alves, Izabela N. F. Gomes, Adriana C. Carloni, Marcela N. Rosa, Luciane S. da Silva, Adriane F. Evangelista, Rui Manuel Reis and Viviane Aline O. Silva

    Citation: Stem Cell Research & Therapy 2021 12:206

    Content type: Review

    Published on:

  44. Immortalized, clonal HB1.​F3.​CD21 human neural stem/progenitor cells (NSCs), loaded with therapeutic cargo prior to intraperitoneal (IP) injection, have been ...

    Authors: Rachael Mooney, Wafa Abidi, Jennifer Batalla-Covello, Hoi Wa Ngai, Caitlyn Hyde, Diana Machado, Asma Abdul-Majid, Yanan Kang, Mohamed Hammad, Linda Flores, Greg Copeland, Thanh Dellinger, Ernest Han, Jacob Berlin and Karen S. Aboody

    Citation: Stem Cell Research & Therapy 2021 12:205

    Content type: Research

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  45. Severe, steroid-resistant asthma (SSRA) is a serious clinical problem in asthma management. Affected patients have severe clinical symptoms, worsened quality of life, and do not respond to steroid, a mainstay ...

    Authors: Bing Dong, Chao Wang, Jing Zhang, Jinrong Zhang, Yinuo Gu, Xiaoping Guo, Xu Zuo, He Pan, Alan Chen-Yu Hsu, Guoqiang Wang and Fang Wang

    Citation: Stem Cell Research & Therapy 2021 12:204

    Content type: Research

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  46. Mesenchymal stem cells (MSCs) provide potential treatments for peritoneal fibrosis. However, MSCs cultured in media containing serum bring risks of infection and other problems. In this study, we compared the ...

    Authors: Kohei Nagasaki, Ayumu Nakashima, Ryo Tamura, Naoki Ishiuchi, Kiyomasa Honda, Toshinori Ueno, Shigehiro Doi, Yukio Kato and Takao Masaki

    Citation: Stem Cell Research & Therapy 2021 12:203

    Content type: Research

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  47. The low survival rate or dysfunction of extracellular matrix (ECM)-based engineered organs caused by the adverse effects of unfavourable local microenvironments on seed cell viability and stemness, especially ...

    Authors: Jiayu Zhang, Tingting Lan, Xue Han, Yuchan Xu, Li Liao, Li Xie, Bo Yang, Weidong Tian and Weihua Guo

    Citation: Stem Cell Research & Therapy 2021 12:202

    Content type: Research

    Published on:

  48. Cholangiocyte senescence is an important pathological process in diseases such as primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). Stem cell/induced pluripotent stem cell-derived exoso...

    Authors: Wenyi Chen, Jiaqi Zhu, Feiyan Lin, Yanping Xu, Bing Feng, Xudong Feng, Xinyu Sheng, Xiaowei Shi, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Lanjuan Li and Hongcui Cao

    Citation: Stem Cell Research & Therapy 2021 12:201

    Content type: Research

    Published on:

  49. In recent decades, a new method of cellular immunotherapy was introduced based on engineering and empowering the immune effector cells. In this type of immunotherapy, the immune effector cells are equipped wit...

    Authors: Faroogh Marofi, Heshu Sulaiman Rahman, Lakshmi Thangavelu, Aleksey Dorofeev, Favian Bayas-Morejón, Naghmeh Shirafkan, Navid Shomali, Max Stanley Chartrand, Mostafa Jarahian, Ghasem Vahedi, Rebar N. Mohammed, Somayeh Shahrokh, Morteza Akbari and Farhad Motavalli Khiavi

    Citation: Stem Cell Research & Therapy 2021 12:200

    Content type: Review

    Published on:

  50. The senescence of dermal fibroblasts (DFLs) leads to an imbalance in the synthesis and degradation of extracellular matrix (ECM) proteins, presenting so-called senescence-associated secretory phenotype (SASP),...

    Authors: Xiangnan Zhao, Yue Liu, Pingping Jia, Hui Cheng, Chen Wang, Shang Chen, Haoyan Huang, Zhibo Han, Zhong-Chao Han, Krzysztof Marycz, Xiaoniao Chen and Zongjin Li

    Citation: Stem Cell Research & Therapy 2021 12:196

    Content type: Research

    Published on:

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ISSN: 1757-6512

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