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  1. Acute myocardial infarction (MI) leads to an irreversible loss of proper cardiac function. Application of stem cell therapy is an attractive option for MI treatment. Adipose tissue has proven to serve as a ric...

    Authors: Wojciech Wystrychowski, Bhagat Patlolla, Yan Zhuge, Evgenios Neofytou, Robert C. Robbins and Ramin E. Beygui
    Citation: Stem Cell Research & Therapy 2016 7:84
    Content type: Research Published on:

  2. In regenerative medicine the maintenance of stem cell properties is of crucial importance. Ageing is considered a cause of reduced stemness capability. The limbus is a stem niche of easy access and harbors two...

    Authors: Laura Tomasello, Rosa Musso, Giovanni Cillino, Maria Pitrone, Giuseppe Pizzolanti, Antonina Coppola, Walter Arancio, Gianluca Di Cara, Ida Pucci-Minafra, Salvatore Cillino and Carla Giordano
    Citation: Stem Cell Research & Therapy 2016 7:83
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:106

  3. Mesenchymal stem cells have been used for cardiovascular regenerative therapy for decades. These cells have been established as one of the potential therapeutic agents, following several tests in animal models...

    Authors: Aastha Singh, Abhishek Singh and Dwaipayan Sen
    Citation: Stem Cell Research & Therapy 2016 7:82
    Content type: Review Published on:

  4. The limbus forms the outer rim of the cornea at the corneoscleral junction and harbours a population of stem cells for corneal maintenance. Injuries to the limbus, through disease or accidents such as chemical...

    Authors: Jeremy John Mathan, Salim Ismail, Jennifer Jane McGhee, Charles Ninian John McGhee and Trevor Sherwin
    Citation: Stem Cell Research & Therapy 2016 7:81
    Content type: Research Published on:

  6. Intrinsic factors and extrinsic signals which control unlimited self-renewal and developmental pluripotency in embryonic stem cells (ESCs) have been extensively investigated. However, a much smaller number of ...

    Authors: Jifeng Liu, Xinlong Luo, Yanli Xu, Junjie Gu, Fan Tang, Ying Jin and Hui Li
    Citation: Stem Cell Research & Therapy 2016 7:79
    Content type: Research Published on:

  8. Although patient-sourced cardiac stem cells repair damaged myocardium, the extent to which medical co-morbidities influence cardiac-derived cell products is uncertain. Therefore, we investigated the influence ...

    Authors: Audrey E. Mayfield, Megan E. Fitzpatrick, Nicholas Latham, Everad L. Tilokee, Melanie Villanueva, Seth Mount, Bu-Khanh Lam, Marc Ruel, Duncan J. Stewart and Darryl R. Davis
    Citation: Stem Cell Research & Therapy 2016 7:60
    Content type: Research Published on:

  9. The critical challenge in tissue engineering is to establish an optimal combination of stem cells, signaling morphogenetic molecules, and extracellular matrix scaffold/microenvironment. The extracellular matri...

    Authors: Rei Kawamura, Yuki Hayashi, Hiroshi Murakami and Misako Nakashima
    Citation: Stem Cell Research & Therapy 2016 7:77
    Content type: Research Published on:

  10. Previously, we demonstrated that poorly differentiated cells of various origins, including tumor-initiating stem cells present in the ascites form of mouse cancer cell line Krebs-2, are capable of naturally in...

    Authors: Evgeniya V. Dolgova, Ekaterina A. Potter, Anastasiya S. Proskurina, Alexandra M. Minkevich, Elena R. Chernych, Alexandr A. Ostanin, Yaroslav R. Efremov, Sergey I. Bayborodin, Valeriy P. Nikolin, Nelly A. Popova, Nikolay A. Kolchanov and Sergey S. Bogachev
    Citation: Stem Cell Research & Therapy 2016 7:76
    Content type: Research Published on:

  11. The intervertebral disc (IVD) has limited self-healing potential and disc repair strategies require an appropriate cell source such as progenitor cells that could regenerate the damaged cells and tissues. The ...

    Authors: Adel Tekari, Samantha C. W. Chan, Daisuke Sakai, Sibylle Grad and Benjamin Gantenbein
    Citation: Stem Cell Research & Therapy 2016 7:75
    Content type: Research Published on:

    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:49

  12. Recent efforts in osteoarthritis (OA) research have highlighted synovial inflammation and involvement of immune cells in disease onset and progression. We sought to establish the in-vivo immune response in col...

    Authors: Eric Farrell, Niamh Fahy, Aideen E Ryan, Cathal O Flatharta, Lisa O’Flynn, Thomas Ritter and J Mary Murphy
    Citation: Stem Cell Research & Therapy 2016 7:74
    Content type: Research Published on:

  13. Proliferation and migration of endothelial progenitor cells (EPCs) play important roles in restoring vascular injuries. β2 adrenergic receptors (β2ARs) are widely expressed in many tissues and have a beneficia...

    Authors: Xiao Ke, Xiao-Rong Shu, Fang Wu, Qing-Song Hu, Bing-Qing Deng, Jing-Feng Wang and Ru-Qiong Nie
    Citation: Stem Cell Research & Therapy 2016 7:73
    Content type: Research Published on:

  14. In plastic surgery, skin flap is an important approach to reconstructive wound repairs. The rat dorsal skin flap is a clinically relevant and popular animal model to investigate and evaluate flap survival and ...

    Authors: Yuan-Yu Hsueh, Duo-Hsiang Wang, Tzu-Chieh Huang, Ya-Ju Chang, Wei-Chi Shao, Tai-Lan Tuan, Michael W. Hughes and Chia-Ching Wu
    Citation: Stem Cell Research & Therapy 2016 7:72
    Content type: Method Published on:

  16. Marrow mesenchymal stem cells (MSCs) can differentiate into specific phenotypes, including chondrocytes, and have been widely used for cartilage tissue engineering. However, cartilage grafts from MSCs exhibit ...

    Authors: Zhuoyue Chen, Jing Wei, Jun Zhu, Wei Liu, Jihong Cui, Hongmin Li and Fulin Chen
    Citation: Stem Cell Research & Therapy 2016 7:70
    Content type: Research Published on:

  18. Label-retaining cells (LRCs) have been recognized as rare stem and progenitor-like cells, but their complex biological features in renal repair at the cellular level have never been reported. This study was co...

    Authors: Xiangchun Liu, Haiying Liu, Lina Sun, Zhixin Chen, Huibin Nie, Aili Sun, Gang Liu and Guangju Guan
    Citation: Stem Cell Research & Therapy 2016 7:68
    Content type: Research Published on:

  19. The transfection of human mesenchymal stem cells (hMSCs) with the hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) gene has been demonstrated to provide biological pacing in dogs with c...

    Authors: Ieva Bruzauskaite, Daiva Bironaite, Edvardas Bagdonas, Vytenis Arvydas Skeberdis, Jaroslav Denkovskij, Tomas Tamulevicius, Valentinas Uvarovas and Eiva Bernotiene
    Citation: Stem Cell Research & Therapy 2016 7:67
    Content type: Research Published on:

  20. Acute respiratory distress syndrome (ARDS) is a life-threatening condition in critically ill patients. Recently, we have found that mesenchymal stem cells (MSC) improved the permeability of human lung microvas...

    Authors: Shuling Hu, Jinze Li, Xiuping Xu, Airan Liu, Hongli He, Jingyuan Xu, Qihong Chen, Songqiao Liu, Ling Liu, Haibo Qiu and Yi Yang
    Citation: Stem Cell Research & Therapy 2016 7:66
    Content type: Research Published on:

  22. Synovial mesenchymal stem cells (SMSC) possess a high chondrogenic differentiation potential, which possibly supports natural and surgically induced healing of cartilage lesions. We hypothesized enhanced chond...

    Authors: Eva Johanna Kubosch, Emanuel Heidt, Anke Bernstein, Katharina Böttiger and Hagen Schmal
    Citation: Stem Cell Research & Therapy 2016 7:64
    Content type: Research Published on:

  23. Interstitial pneumonia in connective tissue diseases (CTD-IP) featuring inflammation and fibrosis is a leading cause of death in CTD-IP patients. The related autoimmune lung injury and disturbed self-healing p...

    Authors: Ming Liu, Xiansheng Zeng, Junli Wang, Zhiping Fu, Jinsong Wang, Muyun Liu, Dunqiang Ren, Baodan Yu, Lixia Zheng, Xiang Hu, Wei Shi and Jun Xu
    Citation: Stem Cell Research & Therapy 2016 7:63
    Content type: Research Published on:

  25. Overexpression of Pim-1 in stem/progenitor cells stimulated cell cycling and enhanced cardiac regeneration in vivo. We proposed that hypoxic preconditioning could increase survival of bone marrow mesenchymal s...

    Authors: You Zhang, Wei Lei, Weiya Yan, Xizhe Li, Xiaolin Wang, Zhenao Zhao, Jie Hui, Zhenya Shen and Junjie Yang
    Citation: Stem Cell Research & Therapy 2016 7:61
    Content type: Research Published on:

  26. Pluripotent, Lin–/CD45–/Sca-1+ very small embryonic-like stem cells (VSELs) in mouse bone marrow (BM) are resistant to total body radiation because of their quiescent nature, whereas Lin–/CD45+/Sca-1+ hematopoiet...

    Authors: Ambreen Shaikh, Deepa Bhartiya, Sona Kapoor and Harshada Nimkar
    Citation: Stem Cell Research & Therapy 2016 7:59
    Content type: Research Published on:

  27. LL-37 is a naturally occurring antimicrobial peptide found in the wound bed and assists wound repair. No published study has characterized the role of LL-37 in the function(s) of human mesenchymal stem cells (...

    Authors: Yoolhee Yang, Hyunju Choi, Mira Seon, Daeho Cho and Sa Ik Bang
    Citation: Stem Cell Research & Therapy 2016 7:58
    Content type: Research Published on:

  28. In vivo imaging is a platform technology with the power to put function in its natural structural context. With the drive to translate stem cell therapies into pre-clinical and clinical trials, early selection...

    Authors: Martin Leahy, Kerry Thompson, Haroon Zafar, Sergey Alexandrov, Mark Foley, Cathal O’Flatharta and Peter Dockery
    Citation: Stem Cell Research & Therapy 2016 7:57
    Content type: Review Published on:

  30. The electromagnetic field (EMF) has a great impact on our body. It has been successfully used in physiotherapy for the treatment of bone disorders and osteoarthritis, as well as for cartilage regeneration or p...

    Authors: Aleksandra Maziarz, Beata Kocan, Mariusz Bester, Sylwia Budzik, Marian Cholewa, Takahiro Ochiya and Agnieszka Banas
    Citation: Stem Cell Research & Therapy 2016 7:54
    Content type: Review Published on:

  31. Extracellular vesicles play a crucial role in intercellular communication by transmitting biological materials from donor cells to recipient cells. They have pathophysiologic roles in cancer metastasis, neurod...

    Authors: Hongyoon Choi and Dong Soo Lee
    Citation: Stem Cell Research & Therapy 2016 7:55
    Content type: Review Published on:

  32. Extracellular vesicles (EVs) are plasma membrane-bound fragments released from several cell types, including mesenchymal stromal cells (MSCs), constitutively or under stimulation. EVs derived from MSCs and oth...

    Authors: Soraia C. Abreu, Daniel J. Weiss and Patricia R. M. Rocco
    Citation: Stem Cell Research & Therapy 2016 7:53
    Content type: Review Published on:

  33. Adipose-derived stem cells (ASCs) are being increasingly recognized for their potential to promote tissue regeneration and wound healing. These effects appear to be partly mediated by paracrine signaling pathw...

    Authors: Simone Riis, Allan Stensballe, Jeppe Emmersen, Cristian Pablo Pennisi, Svend Birkelund, Vladimir Zachar and Trine Fink
    Citation: Stem Cell Research & Therapy 2016 7:52
    Content type: Research Published on:

  34. Pelvic floor dysfunction (PFD) is a group of clinical conditions including stress urinary incontinence (SUI) and pelvic organ prolapse (POP). The abnormality of collagen and elastin metabolism in pelvic connec...

    Authors: Minfei Jin, Ying Chen, Yun Zhou, Yan Mei, Wei Liu, Chenhao Pan and Xiaolin Hua
    Citation: Stem Cell Research & Therapy 2016 7:51
    Content type: Research Published on:

  35. Stem cells from human exfoliated deciduous teeth (SHED) have recently attracted attention as novel multipotential stem cell sources. However, their application is limited due to in vitro replicative senescence...

    Authors: Zhanhai Yin, Qi Wang, Ye Li, Hong Wei, Jianfeng Shi and Ang Li
    Citation: Stem Cell Research & Therapy 2016 7:50
    Content type: Research Published on:

  36. Mesenchymal stem cells (MSCs) represent a heterogeneous cell population that is promising for regenerative medicine. The present study was designed to assess whether VCAM-1 can be used as a marker of MSC subpo...

    Authors: Wenjing Du, Xue Li, Ying Chi, Fengxia Ma, Zongjin Li, Shaoguang Yang, Baoquan Song, Junjie Cui, Tao Ma, Juanjuan Li, Jianjian Tian, Zhouxin Yang, Xiaoming Feng, Fang Chen, Shihong Lu, Lu Liang…
    Citation: Stem Cell Research & Therapy 2016 7:49
    Content type: Research Published on:

  37. Non-viral-based gene modification of adult stem cells with endothelial nitric oxide synthase (eNOS) may enhance production of nitric oxide and promote angiogenesis. Nitric oxide (NO) derived from endothelial c...

    Authors: Nadeeka Bandara, Saliya Gurusinghe, Haiying Chen, Shuangfeng Chen, Le-xin Wang, Shiang Y. Lim and Padraig Strappe
    Citation: Stem Cell Research & Therapy 2016 7:48
    Content type: Research Published on:

  38. Adipose tissue is an attractive source of mesenchymal stem cells (MSC) as it is largely dispensable and readily accessible through minimally invasive procedures such as liposuction. Until recently MSC could on...

    Authors: C. C. West, W. R. Hardy, I. R. Murray, A. W. James, M. Corselli, S. Pang, C. Black, S. E. Lobo, K. Sukhija, P. Liang, V. Lagishetty, D. C. Hay, K. L. March, K. Ting, C. Soo and B. Péault
    Citation: Stem Cell Research & Therapy 2016 7:47
    Content type: Research Published on:

  39. Mesenchymal stromal/stem cells derived from human umbilical cord (UC-MSCs) uniquely combine properties of embryonic and postnatal MSCs and may be the most acceptable, safe, and effective source for allogeneic ...

    Authors: Irina Arutyunyan, Timur Fatkhudinov, Evgeniya Kananykhina, Natalia Usman, Andrey Elchaninov, Andrey Makarov, Galina Bolshakova, Dmitry Goldshtein and Gennady Sukhikh
    Citation: Stem Cell Research & Therapy 2016 7:46
    Content type: Research Published on:

  40. Previous studies have reported that adult mesenchymal stem cells (MSCs) tend to gradually lose their stem cell characteristics in vitro when placed outside their niche environment. They subsequently undergo sp...

    Authors: Stuart Webb, Chase Gabrelow, James Pierce, Edwin Gibb and Jimmy Elliott
    Citation: Stem Cell Research & Therapy 2016 7:45
    Content type: Research Published on:

    The Erratum to this article has been published in Stem Cell Research & Therapy 2016 7:62

  41. Complex interactions among cells of the monocyte-macrophage-osteoclast lineage and the mesenchymal stem cell-osteoblast lineage play a major role in the pathophysiology of bone healing. Whereas the former line...

    Authors: Emmanuel Gibon, Laura Lu and Stuart B. Goodman
    Citation: Stem Cell Research & Therapy 2016 7:44
    Content type: Review Published on:

  42. Multiple sclerosis is a widespread inflammatory demyelinating disease. Several immunomodulatory therapies are available, including interferon-β, glatiramer acetate, natalizumab, fingolimod, and mitoxantrone. A...

    Authors: Beatriz Bravo, Marta I. Gallego, Ana I. Flores, Rafael Bornstein, Alba Puente-Bedia, Javier Hernández, Paz de la Torre, Elena García-Zaragoza, Raquel Perez-Tavarez, Jesús Grande, Alicia Ballester and Sara Ballester
    Citation: Stem Cell Research & Therapy 2016 7:43
    Content type: Research Published on:

  43. Diabetic retinopathy is a common complication of diabetes and the leading cause of irreversible vision loss in the Western world. The reduction in color/contrast sensitivity due to the loss of neural cells in ...

    Authors: Marcelo Ezquer, Cristhian A. Urzua, Scarleth Montecino, Karla Leal, Paulette Conget and Fernando Ezquer
    Citation: Stem Cell Research & Therapy 2016 7:42
    Content type: Research Published on:

  44. Amyotrophic lateral sclerosis (ALS) is a progressive neurological disease that selectively affects the motor neurons. The details of the mechanisms of selective motor-neuron death remain unknown and no effecti...

    Authors: Fernanda Gubert, Ana B. Decotelli, Igor Bonacossa-Pereira, Fernanda R. Figueiredo, Camila Zaverucha-do-Valle, Fernanda Tovar-Moll, Luísa Hoffmann, Turan P. Urmenyi, Marcelo F. Santiago and Rosalia Mendez-Otero
    Citation: Stem Cell Research & Therapy 2016 7:41
    Content type: Research Published on:

  45. Transcription factor-mediated reprogramming can efficiently convert differentiated cells into induced pluripotent stem cells (iPSCs). Furthermore, many cell types have been shown to be amenable to reprogrammin...

    Authors: Shuai Gao, Li Tao, Xinfeng Hou, Zijian Xu, Wenqiang Liu, Kun Zhao, Mingyue Guo, Hong Wang, Tao Cai, Jianhui Tian, Shaorong Gao and Gang Chang
    Citation: Stem Cell Research & Therapy 2016 7:40
    Content type: Research Published on:

  46. Bone marrow mesenchymal stem cells (MSCs) have shown positive therapeutic effects for meniscus regeneration and repair. Preliminary in vitro work has indicated positive results for MSC applications for meniscu...

    Authors: Mary Clare McCorry, Jennifer L. Puetzer and Lawrence J. Bonassar
    Citation: Stem Cell Research & Therapy 2016 7:39
    Content type: Research Published on:

  47. Recently, cell-based therapeutic lymphangiogenesis has emerged and provided hope for lymphatic regeneration. Previous studies have demonstrated that secretomes of mesenchymal stem cells (MSCs) facilitate the r...

    Authors: Chang Youn Lee, Jin Young Kang, Soyeon Lim, Onju Ham, Woochul Chang and Dae-Hyun Jang
    Citation: Stem Cell Research & Therapy 2016 7:38
    Content type: Research Published on:

  48. Mesenchymal stem cells (MSCs) (also known as multipotent mesenchymal stromal cells) possess the capacity for self-renewal and multi-lineage differentiation, and their ability to enhance cutaneous wound healing...

    Authors: Dylan E. Lee, Nagi Ayoub and Devendra K. Agrawal
    Citation: Stem Cell Research & Therapy 2016 7:37
    Content type: Review Published on:

  49. Stem cell therapy can be used for alleviating the neuropathic pain induced by spinal cord injuries (SCIs). However, survival and differentiation of stem cells following their transplantation vary depending on ...

    Authors: Mahmoud Yousefifard, Farinaz Nasirinezhad, Homa Shardi Manaheji, Atousa Janzadeh, Mostafa Hosseini and Mansoor Keshavarz
    Citation: Stem Cell Research & Therapy 2016 7:36
    Content type: Research Published on:

  50. Bone marrow and adipose tissues are known sources of mesenchymal stem cells (MSCs) in horses; however, synovial tissues might be a promising alternative. The aim of this study was to evaluate phenotypic charac...

    Authors: Joice Fülber, Durvanei A. Maria, Luis Cláudio Lopes Correia da Silva, Cristina O. Massoco, Fernanda Agreste and Raquel Y. Arantes Baccarin
    Citation: Stem Cell Research & Therapy 2016 7:35
    Content type: Research Published on:
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